ライフサイエンスコーパス: malate dehydrogenase

1 e of functional groups at the active site of malate dehydrogenase.

2 o-overexpression of Mdh1p, the mitochondrial malate dehydrogenase.

3 om the fusion protein with the mitochondrial malate dehydrogenase.

4 rogenase, and citrate synthase and cytosolic malate dehydrogenase.

5 recipitate of citrate synthase and cytosolic malate dehydrogenase.

6 ction between citrate synthase and cytosolic malate dehydrogenase.

7 coli alkaline phosphatase and mitochondrial malate dehydrogenase.

8 equilibrium for glycogen phosphorylase A and malate dehydrogenase.

9 as we demonstrate with chorismate mutase and malate dehydrogenase.

10 nzymes with multiple isoforms, aconitase and malate dehydrogenase.

11 7998, which encodes a putative mitochondrial malate dehydrogenase.

12 ion of phosphoenolpyruvate carboxylase and L-malate dehydrogenase.

13 e heat-labile proteins, citrate synthase and malate dehydrogenase.

14 hose substrates include the short-lived Mdh2 malate dehydrogenase.

15 as activated primary T cells, that cytosolic malate dehydrogenase 1 (MDH1) is an alternative to LDH a

16 Malate dehydrogenase 1 (MDH1), a key enzyme in the gluta

17 Conversely, the malate dehydrogenase 1 (MDH1)-mediated oxaloacetate-to-m

18 X5 (PEX5C) receptor construct or peroxisomal malate dehydrogenase 1 (pMDH1) cargo protein into sunflo

19 Malate dehydrogenase 1 and malic enzyme 1, enzymes that

20 actor beta 1, follistatin-related protein 1, malate dehydrogenase 1 cytoplasmic, plasma retinol-bindi

21 d in cell-cell contacts) and MDH1 (cytosolic Malate dehydrogenase 1), revealed their role in early st

22 om novel variants of muscle pyruvate kinase, malate dehydrogenase 1, glyceraldehyde-3-phosphate dehyd

23 dride transfer complex (HTC) is assembled by malate dehydrogenase 1, malic enzyme 1, and cytosolic py

24 % ZL islets): increased V(max) of PC (160%), malate dehydrogenase (170%), and malic enzyme (275%); el

25 ys, fructose-1,6-bisphosphatase (FBPase) and malate dehydrogenase 2 are degraded in the vacuole via t

26 Both FBPase and malate dehydrogenase 2 were associated with actin patche

27 es with isolated lactate dehydrogenase-1 and malate dehydrogenase-2 revealed that generation of 2-HG

28 beta-oxidation system as well as peroxisomal malate dehydrogenase 3 and carnitine acetyltransferase.

29 ldolase class II (FBA2) (33%), NAD-dependent malate dehydrogenase (31%) and Cu/Zn superoxide dismutas

30 cinate dehydrogenase (complex II) (+44%) and malate dehydrogenase (+54%) were increased (p < 0.01).

31 within the mitochondria bind this molecule: malate dehydrogenase, a member of Krebs cycle, and adeno

32 , mHsp60(V72I) was less efficient in folding malate dehydrogenase, a putative mHsp60 substrate protei

33 led to increased nitrogen assimilation, NADP-malate dehydrogenase activation, and light vulnerability

34 alate valve capacity, with decreases in NADP-malate dehydrogenase activity (but not protein levels) a

35 ne [IM]) contained less than 1% of the total malate dehydrogenase activity (soluble marker), indicati

36 No malate dehydrogenase activity was detected using macerat

37 ys using liver extract revealed up-regulated malate dehydrogenase activity, but not aspartate transam

38 han TaHsp17.8C-II in preventing heat-induced malate dehydrogenase aggregation.

39 This is also close to the potential of NADPH-malate dehydrogenase, an enzyme known to be regulated by

40 Mitochondrial malate dehydrogenase and citrate synthase are sequential

41 nd fumarase mutants, and diminished again in malate dehydrogenase and citrate synthase mutants.

42 Channeling of oxaloacetate in the malate dehydrogenase and citrate synthase-coupled system

43 tential allergens were identified, including malate dehydrogenase and enolase in AU, and RuBisCo in M

44 urs of NMP with URC, including mitochondrial malate dehydrogenase and glutamic-oxaloacetic transamina

45 n into two target proteins (Escherichia coli malate dehydrogenase and human histone H3) caused homoge

46 alanine amino transferase and glutamate and malate dehydrogenase and malate, there are no links betw

47 ized recombinant sorghum leaf NADP-dependent malate dehydrogenase and oxidized spinach chloroplastic

48 sgenic plants using nodule-enhanced forms of malate dehydrogenase and phosphoenolpyruvate carboxylase

49 phate synthase and chloroplast stromal NADPH-malate dehydrogenase and pyruvate, Pi dikinase.

50 processed precursor forms of precursor yeast malate dehydrogenase and rat liver pALDH also were degra

51 ome targeting signal (PTS2) from peroxisomal malate dehydrogenase and reduced accumulation of 3-ketoa

52 show here, however, that for the folding of malate dehydrogenase and Rubisco there is also an absolu

53 cleotidyl cyclases, protein kinases, lactate/malate dehydrogenases and trypsin-like serine proteases.

54 ctor protein (SteA), and a metabolic enzyme (malate dehydrogenase), and demonstrate practical applica

55 on enzymes, (cytochrome c, cytochrome b, and malate dehydrogenase), and genes important in glycolysis

56 ycle components, including citrate synthase, malate dehydrogenase, and aconitase, resulted in a one-c

57 ing citrate synthase, lactate dehydrogenase, malate dehydrogenase, and aldolase.

58 uding adenosine triphosphate (ATP) synthase, malate dehydrogenase, and calretinin.

59 itates of citrate synthase and mitochondrial malate dehydrogenase, and citrate synthase and cytosolic

60 -tubulin, histone H2b, ribosomal protein S4, malate dehydrogenase, and elongation factor 2, as well a

61 the metabolic enzymes citrate synthase (CS), malate dehydrogenase, and strombine dehydrogenase remain

62 onitase, isocitrate dehydrogenase, fumarase, malate dehydrogenase, and succinate dehydrogenase, but n

63 lyl versus adenylyl cyclases, lactate versus malate dehydrogenases, and trypsin versus chymotrypsin.

64 of the malate-aspartate NADH shuttle (Mdh1 [malate dehydrogenase] and Aat1 [aspartate amino transfer

65 Using malate dehydrogenase as a substrate, TaHsp16.9C-I was sh

66 etolase of the nonoxidative pentose pathway, malate dehydrogenase, asparagine synthetase, and histidi

67 nzymes such as transaldolase, transketolase, malate dehydrogenase, asparagine synthetase, and histidi

68 s for the extreme discrimination achieved by malate dehydrogenases between a variety of closely relat

69 ino acids of the N terminus of mitochondrial malate dehydrogenase bound to mitochondria, but unlike u

70 roEL-GroES-dependent substrates, Rubisco and malate dehydrogenase, but at rates slower than the cis r

71 ise interact only weakly with NADP-dependent malate dehydrogenase, but the apparent second-order rate

72 ial citrate synthase and yeast mitochondrial malate dehydrogenase channels oxaloacetate between the a

73 A Bacillus subtilis gene for malate dehydrogenase (citH) was found downstream of gene

74 d interfacial residues between mitochondrial malate dehydrogenase, citrate synthase, and aconitase we

75 iants of SR1, in the rescue of mitochondrial malate dehydrogenase, citrate synthase, and Rubisco, are

76 us of four tricarboxylic acid cycle enzymes: malate dehydrogenase, citrate synthase, isocitrate dehyd

77 equence analysis identified p36 as cytosolic malate dehydrogenase (cMDH).

78 ate that AIP 37/6 is an isoform of cytosolic malate dehydrogenase (cMDH; approximately 36.3 kDa; pI a

79 aralogous isoforms (paralogues) of cytosolic malate dehydrogenase (cMDH; EC 1.1.1.37; NAD+: malate ox

80 The lactate and malate dehydrogenases comprise a complex protein superfa

81 Targeted enzymes include malate dehydrogenase, cytoplasmic superoxide dismutase 1

82 cytochrome-C) and others (creatine kinase M, malate dehydrogenase cytosolic, fibrinogen and parvalbum

83 of the large, leaderless, multimeric protein malate dehydrogenase did not lead to extracellular accum

84 he transcript encoding the cytosolic form of malate dehydrogenase displayed prominent drug-associated

85 re reports, the activation of NADP-dependent malate dehydrogenase does not display rate saturation ki

86 rcine citrate synthase and porcine cytosolic malate dehydrogenase does not exhibit any channeling of

87 Escherichia coli malate dehydrogenase (EcMDH) and its eukaryotic counterp

88 Five positions in the Escherichia coli malate dehydrogenase (eMDH) sequence, which distinguish

89 We report that a 1.6-fold increase in malate dehydrogenase enzyme specific activity in root ti

90 Codisruption of NDH1 and genes encoding malate dehydrogenases essentially eliminates growth on n

91 Model substrates firefly luciferase and malate dehydrogenase form strong contacts with multiple

92 Malate dehydrogenase from Escherichia coli is highly spe

93 milar analysis carried out on the tetrameric malate dehydrogenase from H. marismortui.

94 the release of cytochrome c, the release of malate dehydrogenase from the mitochondrial matrix, the

95 space to the cytosol; and (c) the release of malate dehydrogenase from the mitochondrial matrix.

96 It protected citrate synthase and malate dehydrogenase from thermal aggregation and inacti

97 the second case, that of a citrate synthase-malate dehydrogenase fusion protein, a transfer efficien

98 Two putative malate dehydrogenase genes, MJ1425 and MJ0490, from Meth

99 lanine dehydrogenase, lactate dehydrogenase, malate dehydrogenase, glutamine transaminase K, aspartat

100 CD spectroscopy reveals that mitochondrial malate dehydrogenase in 3M guanidinium chloride shows li

101 result of the participation of mitochondrial malate dehydrogenase in both citrate cycle and malate sh

102 cipitated citrate synthase and mitochondrial malate dehydrogenase in polyethylene glycol was used at

103 HG is generated by lactate dehydrogenase and malate dehydrogenase in response to hypoxia.

104 Partially folded malate dehydrogenase is devoid of catalytic activity.

105 he activity of a non-Fe-S-containing enzyme (malate dehydrogenase) is unaffected.

106 uch as fructose-1,6-bisphosphatase (FBPase), malate dehydrogenase, isocitrate lyase, and phosphoenolp

107 in like 1 (MdMATEL1)/cytosolic NAD-dependent malate dehydrogenase (MdcyMDH) network regulates malate

108 6.9, and the heat-denatured model substrates malate dehydrogenase (MDH) and firefly luciferase.

109 sHSP from pea, prevented the aggregation of malate dehydrogenase (MDH) and glyceraldehyde-3-phosphat

110 of enthusiastic faculty to develop and adopt malate dehydrogenase (MDH) as a CURE focal point.

111 c(1) complex was identified as mitochondrial malate dehydrogenase (MDH) by matrix-assisted laser deso

112 The kinetics of malate dehydrogenase (MDH) catalyzed oxidation/reduction

113 Malate dehydrogenase (MDH) catalyzes the readily reversi

114 Malate dehydrogenase (MDH) from Escherichia coli is high

115 The evolutionary history of the malate dehydrogenase (MDH) gene family [NAD-dependent MD

116 sequence and phylogenetic relationships of a malate dehydrogenase (MDH) gene from the amitochondriate

117 lus HB27 strain was constructed in which the malate dehydrogenase (mdh) gene was deleted.

118 ne dinucleotide phosphate- (NADP-) dependent malate dehydrogenase (MDH) in the wild-type enzyme and i

119 Two cytosolic malate dehydrogenase (MDH) isozymes have different spati

120 Malate dehydrogenase (MDH) may be important in carbohydr

121 to be more closely related to the cytosolic malate dehydrogenase (MDH) of the same species than to a

122 Two isoenzymes of malate dehydrogenase (MDH) operate as components of the

123 malate to oxaloacetate, catalyzed by either malate dehydrogenase (Mdh) or malate quinone oxidoreduct

124 s, firefly luciferase, citrate synthase, and malate dehydrogenase (MDH) provide new insights into sHS

125 fusion protein of citrate synthase (CS) and malate dehydrogenase (MDH) to assess the chances of oxal

126 hosphate, reduced are used by NADP-dependent malate dehydrogenase (MDH) to reduce OAA to malate, thus

127 oxaloacetate from one of the active sites of malate dehydrogenase (MDH) to the active sites of citrat

128 Malate dehydrogenase (MDH), a key enzyme in the tricarbo

129 ter effect does not extend to the subunit of malate dehydrogenase (MDH), also 33 kDa.

130 For the chaperonin substrates, rhodanese, malate dehydrogenase (MDH), and glutamine synthetase (GS

131 tes aggregation of model substrates, such as malate dehydrogenase (MDH), and inhibits disaggregation

132 atured substrates such as alpha-lactalbumin, malate dehydrogenase (MDH), and the beta-subunit of ATP

133 s TCA cycle enzymes from yeast mitochondrial malate dehydrogenase (MDH), citrate synthase (CS), and a

134 set of GroEL binary complexes with nonnative malate dehydrogenase (MDH), imaged by cryo-electron micr

135 MDH2 encodes mitochondrial malate dehydrogenase (MDH), which is essential for the c

136 Mitochondrial malate dehydrogenase (MDH)-citrate synthase (CS) multi-e

137 coli aspartate aminotransferase (AATase) and malate dehydrogenase (MDH).

138 ate and oxaloacetate catalyzed by the enzyme malate dehydrogenase (MDH).

139 Pex5 (residues 327-462 and 487-653) bound to malate dehydrogenase (MDH; residues 1-323) cargo tetrame

140 tamate oxaloacetate transaminases (GOT), and malate dehydrogenases (MDH).

141 phosphate dehydrogenase (Gpdh) and cytosolic malate dehydrogenase (Mdh1) genotype activity on adult t

142 e (CHS), glutathione S-transferase (GST) and malate dehydrogenase (MDH1) were present in both cultiva

143 hese two isoenzymes as well as mitochondrial malate dehydrogenase, Mdh1p, and have shown that Cit2p w

144 uncated form (deltanMDH2) of yeast cytosolic malate dehydrogenase (MDH2) lacking 12 residues on the a

145 Another gluconeogenic enzyme malate dehydrogenase (MDH2) showed the same degradation

146 ation of fructose-1,6-bisphosphatase (Fbp1), malate dehydrogenase (Mdh2), and other gluconeogenic enz

147 the association of TCA cycle core components malate dehydrogenase (MDH2), citrate synthase (CS), and

148 peroxisomal NADH is reoxidised to NAD(+) by malate dehydrogenase (Mdh3p) and reduction equivalents a

149 Similarly, nine out of ten malate dehydrogenases (MDHs) selected had an arginine re

150 Mitochondrial malate dehydrogenase (mMDH) folds more rapidly in the pr

151 Mitochondrial malate dehydrogenase (mMDH; EC 1.1.1.37) has multiple ro

152 found in the nuclear gene for mitochondrial malate dehydrogenase (mMDH; EC 1.1.1.37) in the living i

153 t and dithiothreitol-denatured mitochondrial malate dehydrogenase (mtMDH), a reaction that normally r

154 l enzymes: beta-lactamase, chymotrypsin, and malate dehydrogenase, none of which are considered targe

155 n between citrate synthase and mitochondrial malate dehydrogenase occurred but no interaction between

156 growth on D-malate as a carbon source, the D-malate dehydrogenase of Escherichia coli (EcDmlA) natura

157 s: NADH dehydrogenase and the NADH-dependent malate dehydrogenase of the M. tuberculosis complex.

158 pig heart citrate synthase and mitochondrial malate dehydrogenase or cytosolic malate dehydrogenase w

159 But in the presence of bound malate dehydrogenase or rhodanese, whereas similar rapid

160 ation with two stringent substrate proteins, malate dehydrogenase or Rubisco, required a minimum of t

161 nge activities against Plasmodium falciparum malate dehydrogenase (pfMDH), which may fill the role of

162 robable serine/threonine-protein kinase NAK, malate dehydrogenase, photosystem I core protein PsaA an

163 determine the function of peroxisomal NAD(+)-malate dehydrogenase (PMDH) in fatty acid beta-oxidation

164 ted by the production of NADH by peroxisomal malate dehydrogenase (PMDH).

165 ukaryotic counterpart, porcine mitochondrial malate dehydrogenase (PmMDH), are highly homologous prot

166 oacetate with citrate synthase-mitochondrial malate dehydrogenase precipitate was inefficient at high

167 rst stable compound, produced by a cytosolic malate dehydrogenase, rather than aspartate produced by

168 re found to function to different degrees as malate dehydrogenases, reducing oxalacetate to (S)-malat

169 mdh encoding aspartate aminotransferase and malate dehydrogenase, respectively, flank era in F. tula

170 nd MDH2 encoding mitochondrial and cytosolic malate dehydrogenases, respectively; and (iv) GLN1 encod

171 is about one-third as efficient as the best malate dehydrogenase selected, whilst the latter had abo

172 del of the fusion protein with the cytosolic malate dehydrogenase shows no clear positive electrostat

173 Malate dehydrogenase specifically oxidizes malate to oxa

174 The heat-denatured malate dehydrogenase that did not refold by the assistan

175 ption of few outlier loci (notably mtDNA and malate dehydrogenase), the positions and slopes of Fundu

176 trate channeling (e.g., of oxaloacetate from malate dehydrogenase to citrate synthase), and use of al

177 shunt, partially bypassing an NADH-dependent malate dehydrogenase to conserve NADH.

178 in refolding guanidine hydrochloride-treated malate dehydrogenase to its native state.

179 Binding of denatured mitochondrial malate dehydrogenase to the apical domain of GroEL cause

180 in 2), and energy metabolism (alpha-enolase, malate dehydrogenase, triosephosphate isomerase, and F1

181 By this mechanism, malate dehydrogenase uses charge balancing to achieve fi

182 complex formed by thioredoxin and monomeric malate dehydrogenase was detected by SDS/PAGE.

183 FtsHi1, FtsHi2, FtsHi4, FtsHi5, FtsH12, and malate dehydrogenase was shown to be important for chlor

184 s more resistant (K(i)(app) = 6 micrometer), malate dehydrogenase was unaffected, and succinate dehyd

185 itochondrial enzymes of citrate synthase and malate dehydrogenase was used, showing that a positive e

186 of yeast aldehyde dehydrogenase (pALDH) and malate dehydrogenase were mutated so that they would not

187 ochondrial malate dehydrogenase or cytosolic malate dehydrogenase were studied using the frontal anal

188 eins, Rv1265, Rv2971, GroEL2, PE_PGRS6a, and malate dehydrogenase, were identified from BCG by mass s

189 d two key enzymes-glycerol dehydrogenase and malate dehydrogenase-were overexpressed to improve PA ti

190 acetic acid was coupled to NADH formation by malate dehydrogenase, which allowed the rates of both in

191 The activation state of malate dehydrogenase, which reflects reduced thioredoxin

192 recognizes partially folded intermediates of malate dehydrogenase with a dissociation constant of 6 m

193 eractions of mitochondrial but not cytosolic malate dehydrogenase with citrate synthase.

194 t and dithiothreitol-denatured mitochondrial malate dehydrogenase with great efficiency.

195 rase and further oxidized to oxaloacetate by malate dehydrogenase with the accompanying reduction of

196 of a ternary complex of porcine cytoplasmic malate dehydrogenase with the alternative substrate alph