ライフサイエンスコーパス: male germ cell

1 but not the terminal differentiation, of the male germ cell.

2 in turn control the developmental program of male germ cells.

3 ), in the normal terminal differentiation of male germ cells.

4 CKT2 plays a role in chromatin regulation of male germ cells.

5 ng events that lead to nuclear compaction of male germ cells.

6 as a decay-promoting factor for Pgk2 mRNA in male germ cells.

7 opment and function of neurons as well as of male germ cells.

8 -represented in somatic cells and in mitotic male germ cells.

9 survival and differentiation of the adjacent male germ cells.

10 e transition into meiosis in both female and male germ cells.

11 rates with repressive epigenetic pathways in male germ cells.

12 nuage and is required for differentiation of male germ cells.

13 ticity of adult somatic stem cells to become male germ cells.

14 tes required for terminal differentiation of male germ cells.

15 cle stoichiometry is tolerated in developing male germ cells.

16 ctivities and distribution during meiosis in male germ cells.

17 enescence, and apoptosis in both somatic and male germ cells.

18 me is dedicated to expression in postmeiotic male germ cells.

19 and transport of specific mRNAs in mammalian male germ cells.

20 their normal function, but is dispensable in male germ cells.

21 rols the mitosis-meiosis transition in mouse male germ cells.

22 testis and increased apoptosis was noted in male germ cells.

23 mice, suggesting that Ovol2 is expressed in male germ cells.

24 ression is also developmentally regulated in male germ cells.

25 which are novel) that are expressed in only male germ cells.

26 ional regulation in lymphocytes, neurons and male germ cells.

27 ssibility that Camk4 has a novel function in male germ cells.

28 hange of basic nuclear proteins in mammalian male germ cells.

29 lpha gene and is transcriptionally active in male germ cells.

30 activity of Zfp127 in pre- and post-meiotic male germ cells.

31 nd all appear to be expressed exclusively in male germ cells.

32 a 108 kDa protein expressed specifically in male germ cells.

33 P colocalizes with actin in the cytoplasm of male germ cells.

34 mmals and is expressed only in the nuclei of male germ cells.

35 d Bmp8b are expressed in similar patterns in male germ cells.

36 (h-mtTFA) expression in somatic tissues and male germ cells.

37 esting that Esx1 expression is restricted to male germ cells.

38 n expressed in fetal, prepubertal, and adult male germ cells.

39 esin-13 is required for axoneme formation in male germ cells.

40 nded our analysis to meiotic and postmeiotic male germ cells.

41 H1 gain- or loss-of function specifically in male germ cells.

42 dinated proliferation and differentiation of male germ cells.

43 onal basal bodies, i.e., sensory neurons and male germ cells.

44 ation is essential epigenetic programming in male germ cells.

45 d spindle poles is severely reduced in Lis-1 male germ cells.

46 e sex chromosome-linked genes in postmeiotic male germ cells.

47 ngly, on a mixed genetic background, rescued male germ cells also generated fully developed teratomas

48 ressor is expressed transiently during mouse male germ cell and eye development.

49 nes are expressed exclusively in postmeiotic male germ cells and are crucial for the compaction of ch

50 lin-1 was indeed present in developing mouse male germ cells and both mouse and guinea pig spermatozo

51 e expression of specific mRNAs in developing male germ cells and brain cells, and is implicated in DN

52 trigger the female Sxl RNA splicing mode in male germ cells and can feminize triploid intersex (2X3A

53 e male germ line, we deleted this sirtuin in male germ cells and found that mutant mice had smaller t

54 hierarchy that drives mitotic transition in male germ cells and implicates gene repression pathways

55 eavage stimulation factor (CstF-64) in mouse male germ cells and in brain, a somatic M(r) 64,000 form

56 ates mRNA transport and translation in mouse male germ cells and is proposed to play a similar role i

57 ce of MAEL in these critical compartments of male germ cells and its interactions provide a link sugg

58 d clusters on the Y chromosome, expressed in male germ cells and possibly associated with sperm motil

59 UHRF1 regulates retrotransposon silencing in male germ cells and provides a molecular link between DN

60 Despite its abundance in male germ cells and significant divergence in primary se

61 d process involving lineage determination of male germ cells and somatic cell types.

62 was localized in freshly isolated, purified male germ cells and somatic cells of mouse and rat teste

63 mine DNA methylation patterns differ between male germ cells and somatic cells, and elements of these

64 tricted its activity to nuclei of developing male germ cells and sperm.

65 piRNA-directed retrotransposon silencing in male germ cells and suggest that MOV10L1 functions as a

66 he Sertoli cell to support the maturation of male germ cells and the production of spermatozoa (sperm

67 Ovol1 in regulating pachytene progression of male germ cells, and identify Id2 as a Ovol1 target.

68 c segmentation, imaginal discs, blood cells, male germ cells, and sex determination.

69 show that L1 elements can retrotranspose in male germ cells, and that expression of a human L1 eleme

70 this, targeted disruption of Rhox5 increased male germ cell apoptosis and reduced sperm production, s

71 ollicles in vitro and in vivo and suppresses male germ cell apoptosis in vivo, thus demonstrating the

72 growth factor binding protein-3 (IGFBP-3) in male germ cell apoptosis.

73 lar, expression of several of these genes in male germ cells appears to be insensitive to sterols, co

74 all microtubule functions in the postmitotic male germ cells are carried out by a single tubulin hete

75 Developing male germ cells are exquisitely sensitive to environment

76 In Drosophila, male germ cells are intimately associated and co-differe

77 osis initiation in mice, and the majority of male germ cells are lost in the meiotic defect of first

78 subcellular locations of TB-RBP and TRAX in male germ cells are modulated by the relative ratios of

79 Male germ cells are sensitive to heat stress and testes

80 ase (sAC), the predominant source of cAMP in male germ cells, are infertile, as the sperm are immotil

81 Male germ cells arrest mitotically, while female germ ce

82 ineage, identifying epigenetic signatures in male germ cells as possible substrates of transgeneratio

83 drogen receptor activity using PSA and human male germ cell-associated kinase (hMAK), as read-outs in

84 , we have identified a protein kinase, human male germ cell-associated kinase (hMAK), which is transc

85 Male germ cell-associated kinase (MAK) and intestinal ce

86 tify a homozygous Alu insertion in exon 9 of male germ cell-associated kinase (MAK) as the cause of d

87 rtion (c.1297_8ins353, p.K433Rins31*) in the male germ cell-associated kinase (MAK) gene (39% of fami

88 Male germ cell-associated kinase (MAK), a direct transcr

89 MAK (male germ cell-associated protein kinase) and MRK/ICK (M

90 iotic genome scanning process that occurs in male germ cells at about the time of birth.

91 equired cell autonomously in differentiating male germ cells at or after the spermatocyte stage.

92 anner, and activates the JAK/STAT pathway in male germ cells at the time of gonad formation.

93 To determine if male germ cell base excision repair activity changes wit

94 nt, and is sufficient to activate aspects of male germ cell behaviour in female germ cells.

95 y equal intensity, but the innate feature of male germ cells being self-renewing while those of the f

96 uting approximately 0.7% of total protein in male germ cells, binds to a consensus promoter element,

97 Here, we use our current understanding of male germ cell biology and TLR function as a starting po

98 genes, which are normally expressed only in male germ cells but are activated by ill-defined epigene

99 nscripts accumulate faster in female than in male germ cells but disappear later in embryogenesis (E1

100 sequence, a strong CGI, is hypomethylated in male germ cells but hypermethylated in somatic tissues,

101 tigens, which are normally expressed only in male germ cells but may be aberrantly expressed in melan

102 ion channel (CatSper2) that is expressed in male germ cells but not in other cells.

103 support some functional microtubules in the male germ cells, but alpha 85E causes dominant male ster

104 egulator of imprinted sites) is expressed in male germ cells, but its function in spermatogenesis has

105 fragment recognized a 1020-bp transcript in male germ cells by northern blot analysis and was used t

106 d to control CREM-dependent transcription in male germ cells by regulating the intracellular location

107 es the transition from mitosis to meiosis in male germ cells by targeting DMRT1 for degradation.

108 al for the specialized maturation of haploid male germ cells called spermiogenesis.

109 A subset of male germ cell cancers presenting with advanced stage ab

110 To explore these FGF4 signals in male germ cell cancers, the multipotent human EC NTERA-2

111 milarly, both our XY and our sex-reversed XX male germ cells clearly showed a male rather than a fema

112 These results suggest that in normal meiotic male germ cells, cyclin A1 participates in the regulatio

113 nes are normally expressed in BORIS-positive male germ cells deficient in CTCF and meCpG contents, bu

114 unofluorescence analysis of developing mouse male germ cells demonstrated partial co-localization wit

115 ex with Ack, and the localization of Dock in male germ cells depends on its SH2 domain.

116 mbination checkpoint is in fact activated in male germ cells despite the lack of apoptosis.

117 , piRNA populations are dynamic, shifting as male germ cells develop.

118 ntinue to corroborate that genes influencing male germ cell development and differentiation have emer

119 In this review, two major aspects of male germ cell development are discussed: underlying mec

120 nd has homologs required for both female and male germ cell development in other organisms; and BOULE

121 recise regulation of CDK2 kinase activity in male germ cell development is crucial for the gonocyte-t

122 and somatic differentiation, but its role in male germ cell development is unknown.

123 s a number of genes specifically involved in male germ cell development, and deletion of the AZFc reg

124 usible genes encoding proteins important for male germ cell development, chromosomal segregation and

125 the core PRC2 subunits EED and SUZ12 during male germ cell development, we identified a requirement

126 es evade methylation more effectively during male germ cell development, whereas other subfamilies sh

127 on (SAGE) representing major stages in mouse male germ cell development, with 150,000 sequence tags i

128 ation imposed by small noncoding RNAs during male germ cell development.

129 ormone receptor-mediated gene activation and male germ cell development.

130 he gene product in the postmeiotic stages of male germ cell development.

131 a mutually exclusive manner with CTCF during male germ cell development.

132 ired for embryonic development and regulates male germ cell development.

133 in parental identity at the H19 locus during male germ cell development.

134 n patterns at the H19 locus during postnatal male germ cell development.

135 kbp6, which has a critical function in mouse male germ cell development.

136 taining genes encoding proteins important in male germ cell development.

137 is predominantly expressed during embryonic male germ cell development; however, it is also expresse

138 X chromosome acquired this prominent role in male germ-cell development as it evolved from an ordinar

139 The beta-TrCP-deficient male germ cells did not enter meiosis, but instead under

140 nslation patterns of populations of genes as male germ cells differentiate and identifies groups of m

141 rmiogenesis, a process through which haploid male germ cells differentiate into spermatozoa, represen

142 lian spermiogenesis, a process where haploid male germ cells differentiate to become mature spermatoz

143 tion are synthesized early in the process of male germ cell differentiation and are stored in a repre

144 , and function of the Golgi apparatus during male germ cell differentiation is unknown.

145 ADAD1 and ADAD2 are essential regulators of male germ cell differentiation with molecular functions

146 tion of key developmental transitions during male germ cell differentiation, including the switch fro

147 tions in the gene-selective transcription in male germ cell differentiation.

148 for regulation and execution of key steps in male germ cell differentiation.

149 t the transcriptional mechanisms that direct male germ cell differentiation.

150 rement for androgen receptor activity during male germ cell differentiation.

151 nction in the control of both blood cell and male germ cell differentiation.

152 , ADAD1 and ADAD2, on testis RNA editing and male germ cell differentiation.

153 s-meiotic arrest complex, to transcripts for male germ cell differentiation.

154 thylation pathways play an essential role in male germ cell differentiation.

155 Polyadenylation in male germ cells differs from that in somatic cells.

156 hich has been implicated in regulating human male germ cell division by prohibiting the degradation o

157 eckpoints that induce apoptosis; conversely, male germ cells do not undergo apoptosis.

158 Messenger RNA polyadenylation in male germ cells does not seem to require the AAUAAA poly

159 sgenic mice, ectopically expressing Figla in male germ cells, downregulated a subset of these genes a

160 Egr4 is expressed at low levels within male germ cells during meiosis and is critical for germ

161 ysis to examine 3D chromatin organization in male germ cells during spermatogenesis.

162 new regulator of the epigenetic landscape of male germ cells during the period of global de novo meth

163 as hypothalamic-pituitary axis disorders and male germ cell dysfunction, 62.0% [95% CI, 59.5%-64.6%])

164 Cas9 restriction to male germ cells elicits autonomous double-strand-break r

165 These male germ cell endo-siRNAs can potentially target hundre

166 nemal complex antigens demonstrated that -/- male germ cells enter meiosis but fail to progress beyon

167 YTHDC2-deficient male germ cells enter meiosis but have a mixed identity,

168 which female germ cells initiate meiosis and male germ cells enter mitotic arrest.

169 entified INSL6 as a novel CUL4B substrate in male germ cells, evidenced by its direct polyubiquinatio

170 elopment, Arf-null mice are blind, and their male germ cells exhibit defects in meiotic maturation an

171 In piRNA-deficient mice, L1-overexpressing male germ cells exhibit excessive DNA damage and meiotic

172 Differentiating male germ cells express a testis-specific form of cytoch

173 ponsive element)-like motifs directs correct male germ cell expression of the beta-galactosidase repo

174 In male germ cells, expression of Gm114 begins at 12.5-13.5

175 armi mutant male germ cells fail to silence Stellate, a gene regulat

176 ssociated RHAMM as an intrinsic regulator of male germ cell fate and as a gatekeeper preventing initi

177 hytene, oocyte meiotic maturation/ovulation, male germ cell fate specification, and a nonessential fu

178 sis, providing a lead compound targeting the male germ cell for contraception.

179 serves a critical function of preparing the male germ cells for fertilization.

180 importance of NOTCH signaling regulation in male germ cells for their survival and differentiation.

181 K4me3/H3K27me3 bivalent) epigenetic state in male germ cells from five mammalian and one avian specie

182 Golgi glycoprotein MGAT4D as a protector of male germ cells from heat stress.

183 in MGAT4D is a novel, intrinsic protector of male germ cells from heat stress.

184 pecifically, in both human somatic and mouse male germ cell genomes, histone Kcr marks either active

185 was only detected in meiotic and postmeiotic male germ cells, giving us the opportunity to examine Cs

186 ion factor, is required for specification of male germ cells in a simultaneous hermaphrodite, the pla

187 Terminal differentiation of male germ cells in Drosophila and mammals requires exten

188 Male germ cells in mammals contain large amounts of a ge

189 a model of 2-step oligoclonal development of male germ cells in mice, the second step distinguishing

190 LH also promotes the survival of meiotic male germ cells in the testis.

191 Pathways enriched in male germ cells included ubiquitin-mediated pathways, pa

192 ind to the promoters of a number of genes in male germ cells including that of Ehmt1 through interact

193 ed in pre-meiotic embryonic female and adult male germ cells, including cyclin D1 (Ccnd1) and stimula

194 Owing to their accessibility, however, male germ cells, including mature sperm, have material a

195 Using a biochemical enrichment of male germ cell intercellular bridges, we identified addi

196 rosophila TZ assembly in sensory neurons and male germ cells involves cooperative actions of Cby and

197 er of asun and that localization of LIS-1 in male germ cells is ASUN dependent.

198 t autoregulation of TRA-2(226) expression in male germ cells is necessary for normal spermatogenesis.

199 Da protein, which accumulates in postmeiotic male germ cells, is abundant in the nucleus.

200 wed that GFP is expressed in differentiating male germ cells, is enriched among BM-derived hematopoie

201 expressed in both Sertoli cells and diploid male germ cells, it has been unclear which of these cell

202 n revealed that cyclin A1 is present only in male germ cells just prior to or during the first, but n

203 Many mRNAs in male germ cells lack the canonical AAUAAA but are normal

204 ng number of genes expressed specifically by male germ cells late in development.

205 nstitution had a significant effect, with XX male germ cells less methylated than the XY controls.

206 HF1, in NIH 3T3 cells and cells of the mouse male germ cell line GC1spg results in global alteration

207 ication and transplantation techniques, this male germ cell line may be used to generate transgenic m

208 loid XY iPSCs can be differentiated into the male germ cell lineage and functional sperm that can be

209 re allele was appropriately expressed in the male germ cell lineage.

210 in concert to direct differentiation of the male germ cell lineage.

211 In this study, metabolic changes in male germ cell lines (GC-2 and TM-4) were analyzed after

212 ne, we have defined culture conditions where male germ cells lose (on STO cells) or maintain (on MSC-

213 In male germ cells many mRNAs are sequestered by proteins i

214 Gene expression and processing during mouse male germ cell maturation (spermatogenesis) is highly sp

215 ogs required for terminal differentiation of male germ cells may activate target gene expression in p

216 , which is specifically expressed in haploid male germ cells, MBD3L2 expression is more widespread.

217 ealed an indispensable role for Cul4a during male germ cell meiosis.

218 ctivation of the heterologous XY bivalent in male germ cells (meiotic sex chromosome inactivation [MS

219 -binding protein Dnd1 (Dnd1(Ter/Ter) ), many male germ cells (MGCs) fail to enter G1/G0 and instead f

220 In response to telomere shortening, male germ cells mostly undergo apoptosis, whereas female

221 reductions in the mRNA levels of postmeiotic male germ cell mRNAs and smaller reductions of meiotic g

222 Polyadenylation of male germ cell mRNAs is unusual, exhibiting increased al

223 gh incidence of alternative 3'-processing in male germ cell mRNAs, including reduced usage of the can

224 ion changes in the vinclozolin-exposed fetal male germ cells (n = 3) to control samples (n = 3), thei

225 In the absence of Sxl, or in male germ cells, Nanos protein is continuously expressed

226 In developing male germ cells, newly synthesized protamine mRNAs are s

227 Male germ cells of all placental mammals express an anci

228 Conditional inactivation of beta-TrCP2 in male germ cells of beta-TrCP1 knockout mice resulted in

229 ard mechanism for the genetic information in male germ cells of mammals.

230 However, nuages in postnatal male germ cells of mice are poorly studied.

231 now report that de novo methylation of male germ cells of mice involves the transient opening o

232 on of bivalent H3K4me3/H3K27me3 chromatin in male germ cells of six vertebrate species.

233 anslational delay in meiotic and postmeiotic male germ cells of the mouse.

234 truct directed tissue-specific expression in male germ cells of transgenic mice.

235 scripts of type 1 hexokinase exist in murine male germ cells, only one form, HK1-sc, is found at the

236 ton-insoluble preparation, whereas in either male germ cells or when exogenously expressed in transfe

237 These observations demonstrated that male germ cells, particularly those with high thiamin tr

238 e is no contribution of somatic cells to the male germ cell pool during development or in adulthood.

239 spermatogonial stem cell divisions unique to male germ cell production are thought to contribute to a

240 he germ cell-specific start site and binds a male germ cell protein that we have termed TASS-1 (trans

241 We have therefore included some relevant male germ cell publications.

242 , mitotic kinesin-like protein 1 (MKLP1) and male germ cell Rac GTPase-activating protein (MgcRacGAP)

243 in new CENP-A loading caused by depletion of male germ cell Rac GTPase-activating protein (MgcRacGAP)

244 ic exit, and recruitment of Aurora B kinase, male germ cell Rac GTPase-activating protein, and RhoA t

245 vivo expression of beta4GalT-I in developing male germ cells requires an essential and previously und

246 The differentiation of mature sperm from male germ cells requires both chromatin remodeling and c

247 Inactivation of PRC1 in male germ cells results in the gradual loss of a stem ce

248 ptical and electron microscopy of HIPK4-null male germ cells reveals defects in the filamentous actin

249 To assess the impact of Adad mutation on male germ cell RNA editing, CRISPR-induced alleles of ea

250 ule1 is necessary for meiotic progression of male germ cells, similar to the known function of boule

251 le2 is required for the maintenance of early male germ cells, similar to vertebrate Dazl To examine i

252 ductive defects of aux males were rescued by male germ cell-specific expression of aux, indicating th

253 The male germ cell-specific fatty acid-binding protein 9 (FA

254 function for an SREBP as a transactivator of male germ cell-specific gene expression.

255 nal roles in meiosis by generating the first male germ cell-specific Phb-cKO mouse.

256 ic dynein in many tissues, could result in a male germ cell-specific phenotype.

257 e-I (beta4GalT-I) gene is transcribed from a male germ cell-specific start site.

258 t how the switch to meiosis is controlled in male germ cells (spermatogonia) remains poorly understoo

259 lates on the heterochromatic Y chromosome in male germ cells, strongly suggesting that it controls th

260 ale germ cells are not under PHF7 control in male germ cells, suggesting that PHF7 is acting in a tis

261 urse cells in direct contact with developing male germ cells, suggesting that they regulate the expre

262 nterstitial cell population is important for male germ cell survival and testis cord formation.

263 n CTCF- and 5-methylcytosine-deficient adult male germ cells, switching DNA occupancy from CTCF to BO

264 During spermatogenesis, male germ cells temporally synthesize many proteins as t

265 ne gene; these are genes normally present in male germ cells (testis) that are also expressed in canc

266 ested prior to abscission in differentiating male germ cells that are interconnected by TEX14-positiv

267 as been recognized that somatic mutations in male germ cells that modify proliferation through dysreg

268 hat RNF17 is a component of a novel nuage in male germ cells--the RNF17 granule, which is an electron

269 t functions in the initiation and passage of male germ cells through meiosis.

270 uirement for cyclin A1 in the progression of male germ cells through the meiotic cell cycle.

271 esting that DND1 regulates mitotic arrest in male germ cells through translational regulation of cell

272 Bag of Marbles (Bam) protein is required for male germ cells to cease spermatogonial TA divisions and

273 tigate the loss of Dicer1 in mouse postnatal male germ cells to determine how disruptions in the miRN

274 nesis, and it functions cell autonomously in male germ cells to ensure spermatozoa motility, whereas

275 at the recombination checkpoint functions in male germ cells to promote repair of meiotic recombinati

276 ophila, eIF4G2, is required specifically for male germ cells to undergo meiotic division and proper s

277 tools for browsing, comparing and searching male germ cell transcriptome data at different stages wi

278 easures were conducted on 488 North American male germ cell tumor (GCT) survivors in relation to cumu

279 Male germ cell tumors (GCTs) are uniquely sensitive to c

280 Adult male germ cell tumors (GCTs) arise by transformation of

281 Adult male germ cell tumors (GCTs) comprise distinct groups: s

282 29 strain mice are predisposed to developing male germ cell tumors (GCTs) of the testes.

283 Adult human male germ cell tumors (GCTs) provide a unique opportunit

284 t the 12q22 region is recurrently deleted in male germ cell tumors (GCTs), suggesting that this site

285 open reading frame and is expressed in human male germ cell tumors.

286 om adopting practices developed for managing male germ cell tumours (GCTs).

287 While most Egr4 null male germ cells undergo apoptosis during early-mid pachy

288 Therefore, DMRT1 determines whether male germ cells undergo mitosis and spermatogonial diffe

289 Because the male germ cell undergoes many more cell divisions across

290 e of piwi-interacting RNAs (piRNAs) in fetal male germ cells undergoing de novo methylation.

291 ription factor that promotes the survival of male germ cells via its effects on cellular metabolism.

292 e stimulation factor (CstF-64) is altered in male germ cells, we examined its expression in mouse tes

293 In male germ cells, we observed a de novo methylation event

294 2 and TM-4, which are two different types of male germ cells were exposed to Silica NP for 24h, and t

295 s that in both mouse hippocampal neurons and male germ cells where the expression of FMRP and NXF2 is

296 ass of small RNAs that bind to MILI in mouse male germ cells, where they accumulate at the onset of m

297 d epigenetic features of closed chromatin in male germ cells, which suggests that CNVs may repress re

298 disruption of gene expression can result in male germ cells with a bias for gamete fusion.

299 genes and proteins were determined in mouse male germ cells, with a particular emphasis on prophase

300 tic Auger electron-emitting radionuclides by male germ cells within the testis is possible after intr