ライフサイエンスコーパス: male-specific

1 A male-specific 35% nephron deficit in microRNA-210 knocko

2 In mice, we show that a male-specific activation of GnRH neurons occurs 0-2 h fo

3 A male-specific AGAMOUS paralog, FhAG2, was identified as

4 at aromatase is also important in activating male-specific aggression and urine marking because these

5 dimorphic but homologous cell types, called male-specific aggression-promoting (MAP) neurons in male

6 ditional novel locus for BUA was seen in the male-specific analysis at DEFB103B (8p23.1) (P = 1.8 x 1

7 had P-values < 1 x 10(-6), of which two were male specific and four were female specific; all were an

8 We find that both the male-specific and embryo-specific exons exist in all Dro

9 In Diptera (Insecta), alternatively spliced male-specific and female-specific products of the double

10 Two male-specific and one female-specific isoforms of T. cas

11 c synaptic inputs and conveying them to both male-specific and sex-shared circuitry.

12 The sex comb is a recently evolved, male-specific array of modified bristles derived from tr

13 Our results uncover a tiny population of male-specific aSP2 neurons that mediate a specific influ

14 It is intriguing that another significant male-specific association was also found between GCK CpG

15 psychiatric diagnoses, we found significant, male-specific associations between the Pro33 allele and

16 IRF1 locus is a strong candidate region for male-specific asthma susceptibility due to the associati

17 tisense oligonucleotides was associated with male-specific attenuation of DNA damage, mitochondrial d

18 and propionic acid at appropriate doses are male-specific attractants and suitable lures for ACP tra

19 scarosides produced by hermaphrodites causes male-specific attraction.

20 We observe a male-specific axonal arbor in the lateral horn whose ela

21 the truncated form of TrkB (TrkB.T1) directs male-specific axonal pruning in mice.

22 In this issue, Lang et al. report use of the male-specific bacteriophage R17, a phage that binds conj

23 is circuitry is coordinated to generate this male-specific behavior, and sets the stage for a circuit

24 courtship circuitry capable of inducing this male-specific behavioral program.

25 itary bee species may reflect differences in male-specific behavioral traits and associated selection

26 function of neuronal circuits that underlie male-specific behaviors in Drosophila, including courtsh

27 e-expressing populations; and play a role in male-specific behaviors.

28 formation of the pigment cell precursors, a male-specific cell type in the embryonic gonad.

29 rons in both sexes; and later in a subset of male-specific cells that included an interneuron and eig

30 ed for the generation and differentiation of male-specific cells.

31 ther the underlying interactions require the male-specific cellular environment.

32 In male-specific CEM (cephalic sensilla, male) cilia, ccpp-

33 courtship behavior was thought to arise from male-specific central neurons, our study shows that the

34 ciliated sensory neuron type K (ASK) and the male-specific cephalic companion neuron (CEM), are requi

35 rting on the association between female- and male-specific characteristics and stroke.

36 Male-specific characteristics increasing stroke risk inc

37 on occurs only in males and is mediated by a male-specific chromatin machinery that leads to global h

38 ping array log R intensity ratios across the male-specific chromosome Y region.

39 putative proprioceptors which integrate into male-specific circuits for copulation.

40 rge from the collective dynamics of a single male-specific class of neurons, the cephalic sensory neu

41 ecific manner in the hippocampus, leading to male-specific cognitive deficits.

42 erve cord to cause activation of P1 neurons, male-specific command neurons that trigger courtship.

43 eadspace odours from males contained a major male-specific compound, identified as (2 S, 5E)-6,10-dim

44 The male-specific connection between the TN1A neurons and th

45 ex-determinant candidate, OGI, that displays male-specific conservation among Diospyros species.

46 UITLESS (FRU) transcription factor, but form male-specific contacts with FRU-expressing neurons; calc

47 technology to activate neurons that generate male-specific courtship song in flies.

48 ata showed that clozapine is associated with male-specific decelerations up to 7 years in multiple ch

49 control the command interneurons through the male-specific, decision-making interneuron PVY and its a

50 ter in magnitude in men and accompanied by a male-specific decline in B-cell specific loci.

51 We observed a male-specific decrease in microglial density in alcohol-

52 in males may have been accounted for by the male-specific decrease of inflammation in white adipose

53 PS-induced maternal immune activation caused male-specific deficits in certain social responses in th

54 Here we report male-specific deficits in striatal function important to

55 me evolution and open avenues for studies of male-specific dispersal in endangered great ape species.

56 e to design genetic markers for studying the male-specific dispersal of this endangered species.

57 these neurons might be promoted in males by male-specific Dsx (Dsx(M)).

58 Activation of male-specific dsx/fru(+) P1 neurons in the brain initiat

59 Finally, we show that the male-specific early replication of the X chromosome is d

60 tivation of a Y-located SRY gene could exert male-specific effects in development and physiology of m

61 Here we present male-specific effects of the mutant SOD1 transgene on pr

62 and a monogamous laboratory lineage revealed male-specific effects.

63 Dmrt1 exhibited early male-specific embryonic expression, preceding the onset

64 ignal of ancient balancing selection at the 'male-specific enhancer' of tan, with exceptionally high

65 e mice, and this finding was associated with male-specific epigenetic activation of hippocampal Cdk5

66 easure a 6-min time window to coordinate two male-specific events during Drosophila mating: sperm tra

67 conserved open reading frame starting in Sxl male-specific exon 3.

68 presented by between-family comparisons, the male-specific exon accumulated nonsynonymous substitutio

69 The homologous male-specific exon is also present in Scaptodrosophila l

70 lation of nonsynonymous substitutions in the male-specific exon occurred at a significantly greater t

71 The evolution of the male-specific exon of dsx thus shows a pattern reminisce

72 exes, the female-specific exons, and the and male-specific exon.

73 C. elegans mate searching is a male-specific exploratory behavior regulated by two comp

74 We determined gametogenesis stage- and male-specific expression and localization of Tdrd6, iden

75 The male-specific expression and splicing is part of a regul

76 tion of this protein, species difference and male-specific expression during the breeding season sugg

77 terility or in the frequencies of genes with male-specific expression in adults.

78 of the genes in Drosophila melanogaster show male-specific expression in adults.

79 PHF7 exhibits male-specific expression in early germ cells, germline s

80 PHF7 exhibits male-specific expression in early germ cells, germline s

81 d transmembrane protein, Sdmg1, owing to its male-specific expression in mouse embryonic gonads.

82 In addition, a homologue of dmd-1 exhibits male-specific expression in Schistosoma mansoni, a deriv

83 to odr-10 only in males, due in part to the male-specific expression of daf-7 in ASJ.

84 We also show that Pde1c has a male-specific expression pattern in the CNS with an incr

85 ow that C. elegans males exhibit an altered, male-specific expression pattern of daf-7 in the ASJ sen

86 egments containing TRA-1-binding sites drive male-specific expression patterns, and RNAi depletion of

87 hronic regulatory genes, some of which drive male-specific expression, suggesting that TRA-1 imposes

88 96 +/- 0.04 day(-1)), but the decay rates of male-specific (F+) coliphages were not significantly dif

89 cating that both c-Kit signals and undefined male-specific factors are required for ILC2 function.

90 d Cox4, was also stimulated by caffeine in a male-specific fashion.

91 pre-Sertoli cells directs the gonad toward a male-specific fate.

92 Ectopic lin-29a is sufficient to impose male-specific features at earlier stages of development

93 me-to-needs: B, 27.741; P = .004), with some male-specific findings.

94 pathway is the recent acquisition in Mus of male-specific Fmo3 gene repression.

95 ransgenic mice to convert naive T cells into male-specific Foxp3(+) regulatory T cells (Tregs) in WT

96 Male-specific Fru (Fru(M)) acts in foreleg GRNs to promo

97 sophila melanogaster males, when a subset of male-specific fruitless (fru)- and doublesex (dsx)-expre

98 Furthermore, the male-specific Fruitless isoform (Fru(M)) is required for

99 The male-specific Fruitless proteins (FruM) act to establish

100 tes throughout prophase I, arguing against a male-specific function for this isoform.

101 sex chromosomes are enriched for genes with male-specific function such as testis genes.

102 ent, dosage-sensitive genes, or have evolved male-specific functionality.

103 moved onto the X chromosome while genes with male-specific functions moved off the X.

104 ensing ion channel ppk29 and was mediated by male-specific GABAergic neurons acting on the GABAA rece

105 eo-Y haplotypes that differ in structure and male-specific gene content.

106 , suppression of RA signaling did not rescue male-specific gene expression in Smad2-mutant testes, in

107 but not Smad3, from XY PGCs led to a loss of male-specific gene expression.

108 lopment directly or indirectly by repressing male-specific gene expression.

109 gnal that represents an epigenetic memory of male-specific gene expression.

110 ontrolled transcripts comprising female- and male-specific gene modules, with greater p38alpha depend

111 or graft survival as assessed by PCR for the male-specific gene.

112 nnotation data from GTEx, we identified four male-specific genes (FBXL7, ITPR3 and RAD51B from epithe

113 ractions in maintaining proper expression of male-specific genes, either directly or via indirect eff

114 isingly, in addition to small RNAs targeting male-specific genes, we show that males also harbor an e

115 y, this is driven primarily by divergence of male-specific genes, while divergence of other sex-linke

116 id (RA)-dependent meiotic entry and inducing male-specific genes.

117 Y sex chromosomes, based on the discovery of male-specific genetic markers in both species.

118 A recent discovery of male-specific genetic markers reveals that these snakes

119 icient mice were previously found to display male-specific germ cell loss and infertility.

120 2 knockout pigs phenocopy knockout mice with male specific germline ablation but other aspects of tes

121 ons in non-sex-specific neurons to produce a male-specific, goal-oriented exploratory behavior.

122 ecific function on POP-1 by recruiting it to male-specific gonadal target genes.

123 The geometric mean of males' specific gravity-adjusted urinary phenol concentr

124 e an important trigger in the development of male-specific hepatosteatosis and secondary tumorigenesi

125 In the male-specific HOB neuron, DAF-19(M) acts downstream of t

126 ugh they mount a T-cell response against the male-specific HY antigen.

127 Moreover, we reveal surprising male-specific impact of RNAi factors on germ cell develo

128 The loss of Spocd1 in mice results in male-specific infertility but does not affect either piR

129 TMEM95 ablation in mice caused complete male-specific infertility.

130 The hermaphrodite signal is conveyed by male-specific interneurons that are postsynaptic to the

131 e mice, and explored whether CC2D1A controls male-specific intracellular signaling.

132 The rate of male-specific inviable or sterile mutations is 5 x 10(-4

133 In Drosophila, the action of the male-specific isoform of fruitless in about 2000 neurons

134 diverting the splicing of Tcdsx pre-mRNA to male-specific isoform.

135 Drosophila dsx encodes female- and male-specific isoforms (DSX(F) and DSX(M)), but little i

136 e mediated by its effects on pigmentation of male-specific leg structures called sex combs.

137 They use the Male Specific Lethal (MSL) complex composed of noncoding

138 chromosome are coordinately regulated by the male specific lethal (MSL) complex to achieve dosage com

139 This is achieved by the male- specific lethal (MSL) complex, which modifies chro

140 In Drosophila, the male-specific lethal (MSL) complex binds to hundreds of

141 nsation by co-opting the dosage-compensation male-specific lethal (MSL) complex to study the mutation

142 es, compensation involves recruitment of the male-specific lethal (MSL) complex to X-linked genes and

143 anogaster males is achieved via targeting of male-specific lethal (MSL) complex to X-linked genes.

144 finity sites (HAS), landing platforms of the male-specific lethal (MSL) complex, are enriched around

145 hesis to explain this phenomenon is that the male-specific lethal (MSL) complex, which is present at

146 ) are 100- to 1,500-bp elements that recruit male-specific lethal (MSL) complexes to the X chromosome

147 The Drosophila male-specific lethal (MSL) dosage compensation complex i

148 MOF is the catalytic subunit of the male-specific lethal (MSL) HAT complex, which plays a ke

149 Each RNA finger binds chromatin and the male-specific lethal (MSL) protein complex and can indiv

150 A complex composed of the male-specific lethal (MSL) proteins and RNA is recruited

151 In Drosophila, the male-specific lethal (MSL) ribonucleoprotein complex med

152 Depletion of MOF or male-specific lethal 1 (MSL1) in mouse ES cells causes a

153 siognomy, but also translationally represses male-specific lethal 2 (msl-2) to prevent dosage compens

154 s, including components of Wnt signaling and male-specific lethal 3 (msl3), regulate the development

155 ion, the CLAMP (chromatin-linked adaptor for male-specific lethal [MSL] proteins) zinc finger protein

156 The male-specific lethal complex mediates this process, but

157 with the binding sites of proteins from the male-specific lethal complex that affects dosage compens

158 The binding of the Drosophila male-specific lethal dosage compensation complex (DCC) e

159 MSL (Male-specific lethal) complex increases transcription on

160 NSL (nonspecific lethal) in humans and MSL (male-specific lethal) in flies.

161 nations of hypomorphic ocm alleles display a male specific lethality similar to mutations in the clas

162 n the abdominal ganglion through female- and male-specific Lgr3 enhancers.

163 ific lincRNAs in male liver, but not that of male-specific lincRNAs in female liver, was associated w

164 Previously, we identified a panel of male-specific loci misexpressed in sterile male hybrids

165 cue behaviors in adulthood consistent with a male-specific loss of CB(1)R-expressing vGlut-1 synaptic

166 nce was assembled, revealing two clusters of male-specific low copy number genes, separated by an amp

167 , isolated from 16 of 17 UCB samples, showed male-specific lysis in vitro.

168 antennal lobe organization, although several male-specific macroglomeruli are present.

169 00 vs. approximately 130), of which four are male-specific macroglomeruli.

170 regulates cAMP intracellular signaling in a male-specific manner in the hippocampus, leading to male

171 for the Z chromosome of the Gouldian finch (male-specific map distance=131 cM), using 618 captive-br

172 identify the transcription factor MYBL1 as a male-specific master regulator of several crucial meioti

173 ductive maturity, which functions to promote male-specific mate-searching behavior.

174 e that SRY directs a previously unrecognized male-specific mechanism of DA cell death and suggests th

175 ection in three mouse models: 1) mismatch of male-specific minor Ags, 2) mismatch of minor Ags distin

176 Ags, 2) mismatch of minor Ags distinct from male-specific minor Ags, and 3) skin transplant.

177 The Y chromosome encodes male-specific minor histocompatibility (H-Y) antigens th

178 are missense mutations in genes that produce male-specific minor histocompatibility (H-Y) antigens.

179 stent with this, F(1) females do not express male-specific molecular germline markers.

180 e sex determination pathway is necessary for male-specific morphogenesis of sex comb bristles.

181 fic patterning of bristle precursor cells or male-specific morphogenesis of sexually monomorphic prec

182 the Drosophila sex comb, a recently evolved, male-specific morphological structure composed of modifi

183 We report the first estimates of male-specific mutational effects in an androdioecious or

184 First, when males are rare, selection on male-specific mutations is less efficient than in hermap

185 soform diversity plays in the formation of a male-specific nervous system.

186 served role of fru in the specification of a male-specific nervous system.

187 Here we identify a male-specific neural pathway that coordinates the timing

188 courtship behaviors and the establishment of male-specific neuronal architecture.

189 ermining genes, doublesex (dsx), specifies a male-specific neuronal component that serves as an execu

190 We reveal here a novel mechanism by which male-specific neurons are generated in Caenorhabditis el

191 study describes a pair of newly discovered, male-specific neurons in C. elegans that control a sex-s

192 w that the drive to explore is stimulated by male-specific neurons in the tail, the ray neurons.

193 that dsx was required for the development of male-specific neurons that coexpressed fruitless (fru),

194 enes, PKD1 and PKD2), which are expressed in male-specific neurons.

195 neurons are overtly dimorphic and identify a male-specific neuropil that integrates inputs from multi

196 If a single decision is used, a male-specific or female-specific meiotic entry would lea

197 transcribed and that most are expressed in a male-specific or male-biased manner.

198 cleus they are enriched in the dense body, a male-specific organelle associated with synapsis and the

199 Previous studies showed that the male-specific organizer of the complex, MSL2, and the ub

200 In Drosophila, male-specific P1 interneurons promote courtship song, as

201 l behavior by decreasing the activity of the male-specific P1 neurons that coexpress the sex determin

202 at Dsk neurons physiologically interact with male-specific P1 neurons, part of a command center for m

203 ion of target genes such as UTY (KDM6c), the male-specific paralog of UTX (KDM6a) We propose that an

204 and H2O2 stress adaptation and produces the male-specific paraquat (superoxide) stress adaptation.

205 In this study, we identified a male-specific pathway for courtship hearing via third-or

206 sponse to the opposite sex is conferred by a male-specific pathway that renders subordinate, sex-shar

207 Androgen receptor (AR) controls the male-specific pattern of Shh in pelvic fins by regulatio

208 this study, we implicate HP-I, an Aedes- and male-specific peptide transferred to females [7], and it

209 known about the mechanism that generates the male-specific perinatal testosterone surge.

210 was analyzed using female-specific pfs25 and male-specific pfmget or mssp qRT-PCR.

211 n mitochondrial DNA, indicating a widespread male-specific phenomenon that focuses interest on the so

212 The male-specific pheromone 11-cis-vaccenyl acetate (cVA) mo

213 d pC1 neurons physiologically respond to the male-specific pheromone cis-vaccenyl acetate (cVA), whil

214 e odorant receptor Or67d and responds to the male-specific pheromone cis-vaccenyl acetate (cVA).

215 However, the influence of male-specific PHF7 on female reproductive biology via ma

216 daf-19m is expressed in male-specific PKD and core IL2 neurons via internal prom

217 Androgens have male-specific prenatal influence over social brain circu

218 portion of the neural circuitry in which the male-specific product of fruitless (fru) is produced, in

219 The male-specific product of the doublesex gene (dsx(M)) is

220 ential for this behavior is specified by the male-specific products of the fruitless (fru(M)) gene; m

221 Male-specific products of the fruitless (fru) gene contr

222 d specifically marks the neurons that form a male-specific projection that encodes timing features of

223 ammation, we sought to determine reasons for male-specific propensity in macrophage migration.

224 ereby not only affecting the pathogenesis of male-specific prostate cancer but also likely contributi

225 results implicate a novel locus that confers male-specific protection from tau pathology and highligh

226 stological sectioning revealed subcuticular, male-specific prothoracic glands connected to pits in th

227 Furthermore, eliminating a large number of male-specific ray neuron targets only partially attenuat

228 evidence of historical exchange between the male-specific region of the human Y and the X in patchy

229 or inverted orientation--are abundant in the male-specific region of the human Y chromosome (MSY) and

230 The male-specific region of the mammalian Y chromosome (MSY)

231 We now report the sequence of the entire male-specific region of the Y (MSY).

232 The male-specific region of the Y chromosome (MSY) has been

233 A), but large-scale sequence analysis of the male-specific region of the Y Chromosome (MSY) has not y

234 of modern horses by screening 1.46 Mb of the male-specific region of the Y chromosome (MSY) in 52 hor

235 Here we finished sequencing of the male-specific region of the Y chromosome (MSY) in our cl

236 ently, the contributions of the genes on the male-specific region of the Y chromosome (MSY) in these

237 Here, we report that the male-specific region of the Y chromosome (MSY) spans app

238 e de novo assembled a draft reference of the male-specific region of the Y chromosome from Illumina s

239 We sequenced the MSY (male-specific region of the Y chromosome) of the C57BL/6

240 Here, we present the first MSY (male-specific region of the Y chromosome) sequences from

241 veloped a set of 493 novel ovine SNPs of the male-specific region of Y chromosome (MSY) by genome map

242 The human MSY (male-specific region of Y chromosome) retains only three

243 A Quick guide to Love Spots: striking male-specific regions of the eye found in some insects t

244 These results demonstrate a cross-species, male-specific relation between UF microstructure and anx

245 interneurons (LUA) to potentiate downstream male-specific reproduction circuits, allowing copulatory

246 As a male-specific risk factor, LOY might explain why males o

247 atic review and meta-analysis of female- and male-specific risk factors for stroke.

248 dmd-1 has a male-specific role in the maintenance and regeneration o

249 er males and females led to the isolation of male-specific scaffolds and supports an XY sex determina

250 Thus, male-specific selection appears as a dominant force shap

251 Mate contact is sensed by male-specific sensilla of the tail, the rays, which subs

252 fically controls TRPP complex trafficking in male-specific sensory neurons and does so in a cell-auto

253 localizes to ciliated endings of C. elegans male-specific sensory neurons and mediates several aspec

254 kinesin-3 KLP-6 and the polycystin PKD-2 in male-specific sensory neurons in C. elegans.

255 Male-specific sequences were used to identify genomic re

256 e control of genes involved in life span and male-specific sex determination in the fly.

257 In addition, signals corresponding to two male-specific sex pheromones were detected in the ejacul

258 uppressed recombination, which surrounds the male-specific sex-determining gene, remains very small,

259 We demonstrate that in C. elegans, male-specific sexual attraction behavior is programmed i

260 xpected repurposing of a master regulator of male-specific sexual behavior to control one module of f

261 cient to convert females into males with all male-specific sexually dimorphic features and male-like

262 ra dsRNA injected final instar larvae showed male-specific sexually dimorphic structures.

263 Male-specific short nucleotide sequences were used to de

264 We propose that male-specific signaling mechanisms are involved in estab

265 Male-specific single-stranded RNA (FRNA) coliphages belo

266 GH infusion suppressed the vast majority of male-specific sites and induced a subset of female-speci

267 the pigment cell precursors, as well as the male-specific somatic gonadal precursors, is non-cell au

268 Isoform b represents the first report of male-specific splicing in C. elegans.

269 expressed throughout a male's life, controls male-specific splicing of the doublesex gene.

270 tive polymerase chain reaction (PCR) for the male-specific SRY gene was performed to validate the PET

271 primers for the SOD1(G93A) transgene or the male-specific Sry gene, and cultured as neurospheres.

272 d the gustducin alpha-subunit GNAT3 leads to male-specific sterility.

273 rimental evidence for vocal elaboration as a male-specific strategy to maintain social bonds with fem

274 o map out the early development of Area X, a male-specific striatal structure.

275 lopment, in the sex comb, a recently evolved male-specific structure found in some Drosophila species

276 We show that PDI-Trans activity is male-specific, surface-expressed, essential for fertiliz

277 wing birth and that this correlates with the male-specific surge of testosterone occurring up to 5 h

278 n/interneuron, integrating a large number of male-specific synaptic inputs and conveying them to both

279 emale (Tcdsxf1, Tcdsxf2 and Tcdsxf3) and one male-specific (Tcdsxm) isoforms.

280 We report the discovery of male-specific thoracic interneurons-the TN1A neurons-tha

281 ale tissues, neo-X genes highly expressed in male-specific tissues undergo increased rates of protein

282 i, particularly for genes with expression in male-specific tissues, but autosomal and X-linked genes

283 neo-Y genes evolve biased expression toward male-specific tissues--the shrinking gene content of the

284 We then performed genetic linkage mapping of male-specific traits important for reproductive isolatio

285 hromosome promotes both the up-regulation of male-specific transcription and origin activation.

286 ophila melanogaster, fruitless (fru) encodes male-specific transcription factors (FRU(M); encoded by

287 ion EXO70C2 allele resulted in a significant male-specific transmission defect (segregation 40%:51%:9

288 In vivo, disruption of RABA4D resulted in a male-specific transmission defect with mutant raba4d pol

289 Male-specific Treg clones against H-Y antigens DBY, UTY,

290 iprocal parental crosses reveal asymmetry in male-specific viability, female fertility, and backcross

291 antle of Mytilus edulis found transcripts of male-specific vitelline coat lysin (VCL) and female-spec

292 e show that 11-cis-vaccenyl acetate (cVA), a male-specific volatile pheromone, robustly promotes male

293 lopmental disorders, including mechanisms of male-specific vulnerability and female-specific resilien

294 s in a reduction of the male life span and a male-specific wing extension/twitching phenotype that oc

295 We identified a gene that induces male-specific wing size and shape differences between Na

296 We found that male-specific Wnt4 expression in mouse Mullerian duct me

297 d to contain sex-determining genes, i.e. the male-specific Y (MSY) region.

298 remain unclear, including the history of the male-specific Y chromosome at this time.

299 The mammalian male-specific Y chromosome plays a critical role in sex

300 icting our analysis to 8.97 Mb of the unique male-specific Y sequence, we identified 6662 high-confid