ライフサイエンスコーパス: mannose

1 s within three TSRs are also modified with C-mannose.

2 ble of generating GDP-glucose as well as GDP-mannose.

3 ion at positions 3, 4, and 6 of the terminal mannose.

4 influence on PTS sugar metabolism, including mannose.

5 ving 2-O-acetylations from double acetylated mannose.

6 a-glucoside PTS sugars, such as fructose and mannose.

7 cromolar range for fullerenes with 12 and 36 mannoses.

8 contribute to the addition of these O-linked mannoses.

9 r 1 (TRF1) and the non-PARylated partner GDP-mannose 4,6-dehydratase (GMD).

10 equires sequential reactions mediated by GDP-mannose 4,6-dehydratase (GMDS) and GDP-4-keto-6-deoxyman

11 ncoding the fucose biosynthetic enzyme GDP-d-mannose-4,6-dehydratase.

12 lycoform designed to eliminate uptake by the mannose 6-phosphate and mannose receptors exhibits impro

13 on the trafficking of the cation-independent mannose 6-phosphate receptor (CI-M6PR).

14 ly recognize cargoes like cation-independent mannose 6-phosphate receptor (CI-MPR) and Insulin-like g

15 mplex, which recycles the cation-independent mannose 6-phosphate receptor (CI-MPR) from endosomes to

16 rk (TGN) transport of the cation-independent mannose 6-phosphate receptor (CI-MPR).

17 the retrograde sorting of Cation-independent Mannose 6-Phosphate Receptor from late endosomes.

18 uolar protein sorting 35 homolog), and M6PR (mannose 6-phosphate receptor) blocked PrP(C) internaliza

19 nto cells via sortilin or cation-independent mannose 6-phosphate receptor, and facilitated the acidif

20 tered distribution of the cation-independent mannose 6-phosphate receptor, which normally sorts acid

21 ilure of fission caused defective sorting of mannose 6-phosphate receptor, with consequently disrupte

22 Here, we demonstrate that mannose 6-phosphate receptor-mediated cellular uptake an

23 6-phosphate, suggesting cation-independent, mannose 6-phosphate receptor-mediated endocytosis from t

24 GlcNAc-1-phosphotransferase, which generates mannose 6-phosphate residues on lysosomal enzymes.

25 These hydrolases acquire a mannose 6-phosphate tag by the action of the GlcNAc-1-ph

26 urable and can be competitively inhibited by mannose 6-phosphate, suggesting cation-independent, mann

27 or type 2 (IGF2) receptor (IGF2R) recognizes mannose 6-phosphate-containing molecules and IGF2 and pl

28 The cation-independent mannose 6-phosphate/insulin-like growth factor-2 recepto

29 e-6-phophate, suggesting cation-independent, mannose-6-phophate receptor-mediated endocytosis from th

30 rable, and can be competitively inhibited by mannose-6-phophate, suggesting cation-independent, manno

31 The mannose-6-phosphate isomerase (Mpi) locus in Semibalanus

32 glucose metabolism by raising intracellular mannose-6-phosphate levels.

33 and N255 glycosylation sites, which contain mannose-6-phosphate motifs important for I2S uptake into

34 tein NPC2, a cargo of the cation-independent mannose-6-phosphate receptor (CI-M6PR).

35 that are agonists of the cation-independent mannose-6-phosphate receptor (CI-M6PR).

36 tion between SNX5 and the cation-independent mannose-6-phosphate receptor (CI-MPR).

37 lls, both the late autophagy pathway and the mannose-6-phosphate receptor (M6PR) pathway are interrup

38 II (IGF2) enhances memory in rodents via the mannose-6-phosphate receptor (M6PR), but the underlying

39 of cargoes, including the cation-independent mannose-6-phosphate receptor and semaphorin 4C, by the m

40 Cation-independent mannose-6-phosphate receptor, also called insulin-like g

41 or (IGF2R), also known as cation-independent mannose-6-phosphate receptor, which is involved in traff

42 ome-to-Golgi retrieval of cation-independent mannose-6-phosphate receptors (CI-MPR) in the soma is di

43 Hippocampal or systemic administration of mannose-6-phosphate, like IGF2, significantly enhances m

44 L cell viability through upregulation of the mannose-6-phosphate- and peptide hormone-interacting rec

45 eceptor, which is involved in trafficking of mannose-6-phosphate-conjugated glycoproteins to lysosome

46 D-mannose, a C-2 epimer of glucose, exists naturally in ma

47 cept galactosylations at the C6 positions of mannose adjacent to the mannose residue being deacetylat

48 In vivo, mannose administration improves survival in a mouse mode

49 tions of modifications (sulfonamide, biotin, mannose) against matched targets (carbonic anhydrase, st

50 ld (longest linear sequence) starting from d-mannose and (S)-propylene oxide as the source of the ste

51 The first examples of mannose and biotin ligands coupled to aqueous carboxy-fu

52 not only to GlcNAc-peptide but also to high-mannose and complex-type N-glycans in the context of N-g

53 fic compositions of densely distributed high-mannose and complex-type N-glycans that account for 1/4

54 annose, galactose, dextran, and a mixture of mannose and galactose.

55 with galactose only and a blended mixture of mannose and galactose.

56 (ER) and require dolichylphosphate-activated mannose and glucose as donor substrates(2).

57 A375-P cells, Con A binds to long, branched mannose and glucose types of oligosaccharides.

58 type I repeats (TSRs) that are modified by C-mannose and O-fucose in Plasmodium spp. and mammals.

59 te and alanine and reduced concentrations of mannose and urea were discriminatory for the presentatio

60 Paucimannosidic, high-mannose, and complex type glycans were identified and th

61 rivatized hexoses, d-glucose, d-galactose, d-mannose, and d-fructose, using only mass spectrometry wi

62 ree biologically important hexoses (glucose, mannose, and galactose).

63 o unprotected carbohydrates, including alpha-mannose, and it was demonstrated here how the interactio

64 stereochemical relationships in the glucose, mannose, and rhamnose series.

65 ion of IFN-gamma on stimulation of dectin-1, mannose, and Toll-like receptors with Candida albicans a

66 torsion angles between the two reducing-end mannoses are different from the free trisaccharide.

67 t the attachment of a GlcNAc on the alpha1,3 mannose arm of N-glycan is essential for FUT8-catalyzed

68 We identify the glycan epitope high mannose as a marker of influenza virus-induced pathogene

69 Hirayama et al. now reveal, by using only mannose as an energy source, the generation of free O-gl

70 O-galloyl-beta-d-mannopyranose (PGM)), with mannose as central core and galloyl substituents, exhibi

71 residues long) containing an alpha1-6-linked mannose backbone with greatly reduced alpha1-2-mannose s

72 ters against both autologous and select high mannose-bearing heterologous tier 2 pseudoviruses than t

73 Alternatively, protein O-linked mannose beta-1,2-N-acetylglucosaminyltransferase 1 (POMG

74 zyme elongating O-Man glycans, the protein O-mannose beta-1,2-N-acetylglucosaminyltransferase, POMGnT

75 Protein O-linked mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMG

76 inin globular (LG) domains, and in protein O-mannose beta1, 2-N-acetylglucosaminyl transferase 1 (POM

77 ) and the carbohydrate recognition domain of mannose binding lectin (MBL) to target native HIV Env (C

78 gland protein that inhibits the function of Mannose Binding Lectin (MBL).

79 Various recombinant mannose binding lectins (MBLs) and MBLs in sera of both

80 We found that mannose binding lectins, proteins naturally present in t

81 tion of T helper cell epitopes, and attracts mannose binding proteins, which could affect the antibod

82 The collectins mannose-binding lectin (MBL) and surfactant protein D (S

83 Collectins such as mannose-binding lectin (MBL) and surfactant protein D (S

84 In this study, we provide evidence that mannose-binding lectin (MBL) binds to beta2-GPI in Ca(++

85 tive pathway factor D and Bb, lectin pathway mannose-binding lectin (MBL), and shared neurotoxic effe

86 We also discovered that ligation of mannose-binding lectin (MBL), which binds to glycans of

87 ontitis increases the serum concentration of mannose-binding lectin (MBL), which exacerbates local in

88 trated in germinal centers in a complement-, mannose-binding lectin (MBL)-, and immunogen glycan-depe

89 allenged when it was shown that mice lacking mannose-binding lectin (MBL)-associated serine protease-

90 TcCalr binds and inactivates C1 and mannose-binding lectin (MBL)/ficolins, important pattern

91 and regulated complement activation through mannose-binding lectin 2.

92 The labels were recognized by the mannose-binding lectin, Con A, and the biotin-binding pr

93 the lectin pathway of complement activation: mannose-binding lectin, ficolin-2, ficolin-3, collectin-

94 in-2, ficolin-3, collectin-10, collectin-11, mannose-binding lectin-associated serine protease-1, and

95 ing lectin-associated serine protease-1, and mannose-binding lectin-associated serine protease-2.

96 etic peptide], TSP2 [thrombospondin-2], MBL [mannose-binding lectin]; and 3 with lower risk: ErbB1 [e

97 Additionally, high-mannose-binding lectins possess a broad capacity to neut

98 Specifically, the mannose-binding lectins that best agglutinate glycodendr

99 Carbohydrate-binding proteins, particularly mannose-binding lectins, have also been shown to bind th

100 age receptor with collagenous structure) and mannose-binding leptin expression.

101 domain structures and identify two conserved mannose-binding sites, which are consistent with general

102 arboring a deletion of the gene encoding the mannose-binding type 1 pilus tip protein FimH demonstrat

103 omes indicated upregulation of a gene in the mannose biosynthesis pathway in females fed on erythrito

104 a terminal galactose on the alpha1-6-linked mannose branch, this lectin has lower affinity for N-gly

105 re, with and without the complete alpha(1,2) mannose branching, and comparatively studied their prote

106 (BTA-beta-d-glucose; BTA-Glc and BTA-alpha-d-mannose; BTA-Man) or disaccharides (BTA-beta-d-cellobios

107 hery or a monosaccharide (BTA-OEG(4)-alpha-d-mannose; BTA-OEG(4)-Man) at the end of a tetraethylene g

108 d the experimental studies and showed that C-mannoses can be involved in intramolecular hydrogen bond

109 er, wild-type Fbs1 preferentially binds high-mannose-containing glycans.

110 host glycans by increasing fucosylation and mannose content, while decreasing sialylation.

111 uding N-acetylglucosamine, which bisects the mannose core.

112 charides found were d-xylose, d-galactose, d-mannose, d-glucose, d-arabinose, d-rhamnose and d-glucur

113 Mannose-decorated NPs showed better targeting ability to

114 the trypanosome de novo pathway enzymes GDP-mannose dehydratase (GMD) and GDP-fucose synthetase (GME

115 zes influenza virus-infected cells in a high mannose-dependent manner.

116 Glucose and mannose esterified at O-6 by a synthetic alpha-ramified

117 ar-containing [60]fullerene units (total 120 mannoses)-exhibit an outstanding antiviral activity with

118 's normal role, which is to trap and destroy mannose-expressing pathogens.

119 mannosidase could be known to hydrolyze beta-mannose, for example, but from what is presently hard to

120 t for preparation of those 2-azido-2-deoxy-d-mannoses from their corresponding thioglycosides.

121 ctose, arabinose, glucose, rhamnose, xylose, mannose, fructose and ribose) plus inositol as internal

122 abinose, glucose, sucrose, rhamnose, xylose, mannose, fructose, and ribose were quantified in packed

123 bohydrate-based targeting moieties including mannose, galactose, dextran, and a mixture of mannose an

124 and mouse CD23 demonstrate that they bind to mannose, GlcNAc, glucose, and fucose and to glycoprotein

125 ruses with targeted glycan deletion and high-mannose glycan enrichment.

126 d chromatographic separation of over 20 high-mannose glycan isomers in ribonuclease B and a diverse r

127 influenza HA depends on the presence of high-mannose glycan on the head region, our data demonstrate

128 High-mannose glycan with five mannose residues (Man(5)GlcNAc(

129 ion with hemagglutinin (HA) head region high-mannose glycan(s).

130 LPAIV strains do not have the required high-mannose glycans and do not interact with SP-D, and that

131 rfamily of adhesion molecules carry O-linked mannose glycans at conserved sites and it was recently d

132 most neutralizing antibodies target the high-mannose glycans found on the surface envelope glycoprote

133 te "N165" (H3 numbering) is occupied by high-mannose glycans in H3 HA but by complex glycans in all L

134 on against tier 2 pseudoviruses bearing high-mannose glycans than noncomplexed ch.SOSIP trimer immuno

135 AN1A1, leading to elevation of extended high-mannose glycans with terminating alpha-1,2-mannose resid

136 ylation pattern with a preponderance of high-mannose glycans.

137 High-mannose glycoform preferentially samples conformations t

138 Since the presence of head region high-mannose glycosites dictates SP-D activity, the ability t

139 both H1 and H3 HAs have one or more key high-mannose glycosites in the head region, little is known a

140 The positions of high-mannose glycosites on the HA of human H1N1 and H3N2 stra

141 on protein-1 also exclusively displayed high-mannose glycosylation at Asn-137.

142 ecular modeling suggested that extended high-mannose glycosylation at the helical domain of transferr

143 s identified alterations in a number of high mannose, hybrid and complex N-glycans that were localize

144 s, including homo- and mixed N-glycans (high-mannose, hybrid and complex types) that were prepared by

145 ontaining all classes of glycopeptides (high mannose, hybrid, and complex) measured with standard (20

146 y glycans, varying in the proportion of high-mannose/hybrid and complex-type glycans.

147 ites that are unoccupied or occupied by high-mannose/hybrid or complex-type glycans.

148 linked on each glycopeptide, including high-mannose/hybrid, biantennary, and triantennary with/witho

149 s of a series of sequentially truncated high-mannose IgG1 Fc glycoforms, we found that the C'E loop a

150 Sugar analysis indicated the presence of mannose in each of the oligomers.

151 ty are well characterized, the function of D-mannose in T cell immune responses remains unknown.

152 locus, encoded by manLMN, was expressed as a mannose-inducible operon that exhibited the most influen

153 nstrated that supraphysiological levels of D-mannose inhibit tumour growth and stimulate regulatory T

154 th involved C-type lectin receptors, because mannose injection decreased arginase activity induction

155 nd more intimately with its two reducing-end mannoses into the domain A binding site of CV-N than wit

156 D-mannose is a monosaccharide approximately a hundred time

157 Induction of high mannose is dependent upon the unfolded protein response

158 Mannose is one of the fundamental building blocks of gly

159 less well-studied kinases PIM3 and protein O-mannose kinase (POMK).

160 ated serine/threonine kinase 2 and protein-o-mannose kinase SGK196 in all disease groups suggests a k

161 Targeting the inferred mannose-lectin interaction holds therapeutic promise.

162 conclusively show that it cleaves only beta-mannose linkages.

163 y and that affinity was greatly enhanced for mannose-linked alpha1-2 or alpha1-4 to a second mannose

164 Mannose, lyxitol, and shikimic acid predicted higher inf

165 -(1-4)-linked backbones of glucose (Glc) and mannose (Man) units.

166 sing a library of fluorinated glucose (Glc), mannose (Man), and galactose (Gal) derived by systematic

167 nd high-mannose structures with five and six mannoses (Man(5-6)GlcNAc(2)) were major glycans on the v

168 gnizing the 5-methylthio-D-xylofuranose(MTX)-mannose(Man) cap epitope, performed the best, was less i

169 he CRD in complex with a mammalian-type high-mannose Man9GlcNAc2 oligosaccharide exhibited interactio

170 unrecognized immunoregulatory function of D-mannose may have clinical applications for immunopatholo

171 It is not known whether D-mannose metabolism affects the function of non-prolifera

172 is led us to explore the function of MPI and mannose metabolism in liver development and adult liver

173 ata indicate the prospect that modulation of mannose metabolism pathways could reduce HSC activation

174 s on the influence of spacer length (between mannose-mimicking headgroups and quaternary nitrogen cen

175 liposomes of cationic amphiphiles containing mannose-mimicking shikimoyl headgroup are promising DNA

176 We have previously developed a potent mannose-modified lipid calcium phosphate (LCP) nanoparti

177 a protein required for addition of specific mannose molecules to the assembling N-glycan precursors

178 esented very low amount (~1%) of glucose and mannose, monosaccharides not included in the pectin stru

179 Together, our data argue that the high mannose motif is an infection-associated molecular patte

180 eveal a Vpr-Nef-Env axis that hijacks a host mannose-MR response system to facilitate infection while

181 High-mannose N-glycans exhibited elevated expression levels i

182 alylated N-glycans and higher levels of high-mannose N-glycans, respectively.

183 s well as to the monosaccharides l-fucose, d-mannose, N-acetylglucosamine, N-acetylgalactosamine, and

184 at the cadherin superfamily carries O-linked mannose (O-Man) glycans at highly conserved residues in

185 rfamily of adhesion molecules carry O-linked mannose (O-Man) glycans at highly conserved sites locali

186 , we identified and characterized unexpected mannose oligomers that are alpha(1-2/3) linked.

187 Griffithsin (GRFT) is high-mannose oligosaccharide binding lectin that has shown in

188 topes identified on CD11b/CD18 included high Mannose oligosaccharides recognized by the Galanthus Niv

189 xture of afucosylated, fucosylated, and high mannose oligosaccharides was separated in the range of 1

190 und to a fucose mimetic; that is, a terminal mannose on an N-glycan attached to a symmetry-related mo

191 example, the type 1 pilus adhesin FimH binds mannose on the bladder surface, and mediates colonizatio

192 gs, the presence of the branching alpha(1,2) mannose on the LM glycans increases their binding toward

193 The Con A - mannose (or glucose) type glycans present on WM35 cell s

194 the endoplasmic reticulum folding process, C-mannoses orient the underlying tryptophan residues and f

195 erdependent NGS of a microdomain in the high-mannose patch (HMP).

196 CCR5 co-receptor binding site, with the high-mannose patch glycans serving to camouflage it from most

197 The high-mannose patch on HIV Env is a preferred target for broad

198 at forms a localized subdomain of the native mannose patch.

199 uncover a previously unappreciated role for Mannose phosphate isomerase (MPI) as a metabolic enzyme

200 disorder in which children with mutations in mannose phosphate isomerase (MPI) develop liver fibrosis

201 CIGB-EPO showed the greatest variety of high-mannose-phosphate structures.

202 splayed robust binding to nonsialylated high-mannose phosphorylated glycans, even as the recognition

203 enaturation processes, and the presence of C-mannoses promoted the oxidative folding of a reduced and

204 rophosphorylase, SVEN_3972 is an unusual ITP-mannose pyrophosphorylase, and SVEN_2781 is a pyrophosph

205 eath ligand-1 (PD-L1), Mac-2, and macrophage mannose receptor (CD206) and producing Klf4, Il10, Retnl

206 SBP) and quantified the soluble form of the mannose receptor (CD206) and tumor necrosis factor by en

207 e activation including arginase-1 (ARG1) and mannose receptor (CD206).

208 pressing the multi-ligand endocytic receptor mannose receptor (CD206/MRC1) contribute to tumor immuno

209 absent in the related collagen receptor, the mannose receptor (MR or CD206), which consistently does

210 MSCs also expressed mannose receptor (MR) that was found to endocytose rhoda

211 -derived macrophages (BMDMs) in vitro and by mannose receptor (MR)(hi) dermal macrophages in vivo com

212 Here, we report that the macrophage mannose receptor (MR), is a restriction factor targeting

213 , such as the C-type lectin immune receptors mannose receptor (MR), macrophage galactose lectin (MGL)

214 hese include the antiinflammatory macrophage mannose receptor and arginase-1.

215 two key C-type lectin receptors, namely the mannose receptor and DC-specific ICAM 3 nonintegrin at p

216 g are inhibited following PLY binding to the mannose receptor C type 1 (MRC-1) in human dendritic cel

217 PanIN), and resulted in the accumulation of (mannose receptor C type 1) MRC1+, (arginase 1) Arg+ macr

218 inity for both the insulin receptor (IR) and mannose receptor C-type 1 (MR), which functions to clear

219 ferator-activated receptor gamma (PPARG) and mannose receptor C-type 1 (MRC1), suggesting that PRMT1

220 he parasite load was reduced in mice lacking mannose receptor C-type 1.

221 reased alternative M2-like activation marker mannose receptor CD206, yet lack of GLUT1 was not a crit

222 ipase A2 receptor (PLA2R) is a member of the mannose receptor family found in podocytes in human kidn

223 In contrast to cDC1, RPM used the mannose receptor for Ag uptake and employed the proteaso

224 Mannose receptor knockout (MR(-/-)) mice lack the abilit

225 manner, which can be blocked by injection of mannose receptor ligands.

226 DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endoc

227 5, thereby illuminating the structure of the mannose receptor protein family.

228 resolution of inflammation, Dectin-1, CD206 (mannose receptor), and IL-4R.

229 macrophages expressing arginase 1 (ARG1) and mannose receptor, C type 1 (MRC1).

230 egfp)(y251) transgenic zebrafish that uses a mannose receptor, C type 1 (mrc1a) promoter to drive str

231 sh-a2 tumors showed a reduced expression of mannose receptor-1 (CD206), interleukin-10, transforming

232 an alternative phenotype being both CD68 and mannose receptor-positive, expressing carbonic anhydrase

233 glycans also increases the binding with the mannose receptor.

234 within the human MRC1 gene that encodes the mannose receptor.

235 brin or the endocytic collagen receptor, the mannose receptor.

236 s, mannose-receptor positive macrophages and mannose-receptor negative myeloid cells.

237 redominance of two hematopoietic cell types, mannose-receptor positive macrophages and mannose-recept

238 minate uptake by the mannose 6-phosphate and mannose receptors exhibits improved circulation time and

239 the C6 positions of mannose adjacent to the mannose residue being deacetylated (subsite -1 and +1).

240 the axially oriented 2-O-acetylations on any mannose residue in an oligosaccharide, including double

241 termini of the glycan, with the reducing-end mannose residue ligated to Ca(2+) in a primary binding s

242 ry binding site and the nonreducing terminal mannose residue occupying an adjacent secondary site.

243 where the axially oriented C2-hydroxyl of a mannose residue points toward the Ser41 of the catalytic

244 nose-linked alpha1-2 or alpha1-4 to a second mannose residue.

245 High-mannose glycan with five mannose residues (Man(5)GlcNAc(2)), a complex biantennar

246 can chains to remove all glucose and several mannose residues before extension into complex-type stru

247 Silencing MR or deleting mannose residues on Env rescues Env expression in HIV-1-

248 ng the binding of ligands to alpha1,2-linked mannose residues on Env.

249 h-mannose glycans with terminating alpha-1,2-mannose residues.

250 ified: 4 monosaccharides (glucose, fructose, mannose, rhamnose), 11 disaccharides (sucrose, trehalose

251 : mannose, ribose, lyxose, lyxitol (0.5 mo); mannose, ribitol, glycerol, isothreonic acid, lyxitol (2

252 ncreased in milk from OB women and included: mannose, ribose, lyxose, lyxitol (0.5 mo); mannose, ribi

253 cosylation patterns, primarily consisting of mannose-rich N-glycans.

254 we show that supraphysiological levels of D-mannose safely achievable by drinking-water supplementat

255 -GMP) and requires production of the type IV mannose-sensitive hemagglutinin (MSHA) pilus.

256 We demonstrated that mannose-sensitive type 1 fimbria is involved in the init

257 he wild type, due to increased expression of mannose-sensitive type 1 pili.

258 f glycan structural variants, including high mannose, sialylated, and terminal galactosylated species

259 nnose backbone with greatly reduced alpha1-2-mannose side chains and no arabinose caps.

260 h as a high abundance of phosphorylated high-mannose species and severely truncated small glycans hav

261 Importantly, components of the mannose-specific EII also acted to prevent the early ons

262 The mannose-specific EII locus, encoded by manLMN, was expre

263 In vitro, D-mannose stimulated Treg cell differentiation in human an

264 iometry at O-fucosylation sites and variable mannose stoichiometry at C-mannosylation sites.

265 annose (Man(3-4) GlcNAc(2)Fuc(0-1)) and high-mannose structures with five and six mannoses (Man(5-6)G

266 potent class of antiviral agents that target mannose sugars on the envelope protein of HIV-1.

267 We further demonstrate that mannose supplementation can attenuate HSC activation, le

268 Here, we show that D-mannose suppresses LPS-induced macrophage activation by

269 n for three hexoses (glucose, galactose, and mannose), three pentoses (xylose, arabinose, and ribose)

270 ol glycan class B, which transfers the third mannose to the GPI.

271 ymes of the DPY19 family that transfer alpha-mannoses to tryptophan residues in the sequence WX (2)WX

272 ent the crystal structure of an NST, the GDP-mannose transporter Vrg4, in both the substrate-free and

273 The structure of the yeast GDP-mannose transporter, Vrg4, revealed a requirement for sh

274 ucing pathology due to loss of the Golgi GDP mannose transporter.

275 precursor, a central orthogonally protected mannose trichloroacetimidate donor was coupled to OH-5 o

276 to spatially separate MNS3 from ER-localized mannose trimming steps that generate the glycan signal r

277 ur study we have compared the recognition of mannose type glycans in melanocytes (HEMa-LP) and melano

278 scherichia coli strains and its natural high-mannose type N-glycan binding epitopes on uroepithelial

279 roma region were imaged, revealing that high-mannose type N-glycans were predominantly expressed in t

280 alpha(1-6)-linked mannosides of natural high-mannose type N-glycans with similar affinity.

281 uses exhibit significant proportions of high-mannose type N-linked glycans throughout the head domain

282 the degradation/processing of mammalian high-mannose-type (HM-type) N-glycans in the intestine.

283 cells, which confer mostly complex- and high-mannose-type glycans; and (ii) insect (Sf9) cells, which

284 show that ionizing radiation increases high mannose-type N-glycans and decreases glycosaminoglycans.

285 ly mannan alignment, including the number of mannose units and the branched motif of LM, affects prot

286 An increase in the number of mannose units on the glycans also increases the binding

287 e catalytic removal of terminal alpha-linked mannose units.

288 activation, our study points towards safe D-mannose utilization as an effective intervention against

289 that lack miR-223 showed a decrease of high mannose versus sialylated sugars on N-glycoproteins such

290 Serum glucose, ADP fibrinogen, and mannose were among the strongest predictors of progressi

291 accharides consist of galactose, glucose and mannose whereas the acidic polysaccharides contain fucos

292 s response of LPS-activated macrophages to D-mannose, which impairs glucose metabolism by raising int

293 e generation of C1-substituted glucal from d-mannose, which was further converted to 1,2-disubstitute

294 oligosaccharide, including double acetylated mannoses, while the RiCE2 is active on 3-O-, 4-O-, and 6

295 lycosylation of O-6 of the central branching mannose with an alpha-(1->2)-alpha-(1->6)-linked mannotr

296 PIGG is the enzyme that modifies the second mannose with ethanolamine phosphate, which is removed so

297 with predominance of glucose, galactose and mannose with no uronic acids detection; Flavourzyme extr

298 ation of various protected 2-azido-2-deoxy-d-mannoses with primary triflate electrophiles afforded co

299 where loop 83-89 closes to engage Ca(2+) and mannose without triggering allostery that opens the lect

300 inose, glucose, galacturonic acid, rhamnose, mannose, xylose and traces of glucuronic acid.