ライフサイエンスコーパス: mannose 6-phosphate

1 -methyl-mannoside but not in the presence of mannose 6-phosphate.

2 tors because their glycans are modified with mannose 6-phosphate.

3 could permit rotation of the C-2-C-3 bond of mannose 6-phosphate.

4 ins 1-3, was solved in the presence of bound mannose 6-phosphate.

5 normal liver growth and secreted enzyme with mannose 6-phosphate.

6 alpha-galactosidase, which contains 117 pmol mannose 6-phosphate.

7 , human alpha-galactosidase A, that contains mannose 6-phosphate.

8 dent of perforin and could not be blocked by mannose-6-phosphate.

9 Either 100 mul of 600 mM Mannose-6-Phosphate (29 animals), or 100 mul of phosphat

10 uding beta-D-fructose 6-phosphate and beta-D-mannose 6-phosphate, a precursor and an intermediate of

11 PMI), which catalyzes the interconversion of mannose 6-phosphate and fructose 6-phosphate.

12 lycoform designed to eliminate uptake by the mannose 6-phosphate and mannose receptors exhibits impro

13 de reduction (PerT-GUS) eliminated uptake by mannose 6-phosphate and mannose receptors in cultured ce

14 in in 6.75 M trifluoroacetic acid to release mannose 6-phosphate and quantitation of the released man

15 rin/heparin sulfate, N-acetyl-D-glucosamine, mannose-6-phosphate, and laminarin were found to inhibit

16 L cell viability through upregulation of the mannose-6-phosphate- and peptide hormone-interacting rec

17 e of interconverting mannose 1-phosphate and mannose 6-phosphate, as well as glucose 1-phosphate and

18 hosphotransferase, the enzyme that initiates mannose 6-phosphate biosynthesis.

19 nd more specifically to HSCs, we synthesized mannose 6-phosphate-bovine serum albumin (M6P-BSA) by ph

20 SCs) of fibrotic rats after conjugation with mannose 6-phosphate-bovine serum albumin.

21 eceptor, which is involved in trafficking of mannose-6-phosphate-conjugated glycoproteins to lysosome

22 role in the trafficking of newly synthesized mannose 6-phosphate-containing acid hydrolases to the ly

23 or type 2 (IGF2) receptor (IGF2R) recognizes mannose 6-phosphate-containing molecules and IGF2 and pl

24 taining N-linked carbohydrates modified with mannose 6-phosphate groups.

25 PMM2 (mannose 6-phosphate --> mannose 1-phosphate) and MPI (ma

26 omal enzyme, alpha-l-iduronidase, from which mannose 6-phosphate had been removed.

27 The mannose 6-phosphate/IGF-2 receptor has been proposed to

28 (IGFII) was prepared for endocytosis by the mannose 6-phosphate/IGFII receptor.

29 s been developed to quantitate the amount of mannose 6-phosphate in glycoproteins using high-pH anion

30 The amount of mannose 6-phosphate in the electroblots following hydrol

31 ase was taken up by MPS VII fibroblasts in a mannose 6-phosphate-independent manner, and its uptake w

32 c proteins were additionally endocytosed via mannose-6-phosphate-independent routes.

33 These data support a role for LIMP-2 as the mannose-6-phosphate-independent trafficking receptor for

34 Further, it carries mannose 6-phosphate, indicating lysosomal sorting via ma

35 The mannose 6-phosphate/insulin-like growth factor 2 recepto

36 CD222, also known as the cation-independent mannose 6-phosphate/insulin-like growth factor 2 recepto

37 The cation independent mannose 6-phosphate/insulin-like growth factor 2 recepto

38 on assays with radiolabeled CTGF and soluble mannose 6-phosphate/insulin-like growth factor 2 recepto

39 act of one of the Plg binding molecules, the mannose 6-phosphate/insulin-like growth factor 2 recepto

40 Cell surface mannose 6-phosphate/insulin-like growth factor II recept

41 The mannose 6-phosphate/insulin-like growth factor II recept

42 a in early postnatal life is mediated by the mannose 6-phosphate/insulin-like growth factor II recept

43 To explore a possible role for the mannose 6-phosphate/insulin-like growth factor II recept

44 gen activator receptor (uPAR) binding by the mannose 6-phosphate/insulin-like growth factor II recept

45 Mannose 6-phosphate/insulin-like growth factor II recept

46 The cation-independent mannose 6-phosphate/insulin-like growth factor-2 recepto

47 Among the 15 extracellular domains of the mannose 6-phosphate/insulin-like growth factor-2 recepto

48 We show that CREG binds directly to the mannose-6-phosphate/insulin-like growth factor II recept

49 ble for the initial step in the synthesis of mannose 6-phosphate is UDP-N-acetylglucosamine:lysosomal

50 The mannose-6-phosphate isomerase (Mpi) locus in Semibalanus

51 glucose metabolism by raising intracellular mannose-6-phosphate levels.

52 Hippocampal or systemic administration of mannose-6-phosphate, like IGF2, significantly enhances m

53 -phosphate --> mannose 1-phosphate) and MPI (mannose 6-phosphate <--> fructose 6-phosphate) deficienc

54 he enzyme that initiates the addition of the mannose 6-phosphate lysosomal sorting signal on acid hyd

55 ates the second step in the synthesis of the mannose 6-phosphate lysosomal targeting signal on acid h

56 Subsequent modeling of mannose 6-phosphate (M6P) into the active site of the en

57 previously showed that the neonate uses the mannose 6-phosphate (M6P) receptor to transport phosphor

58 or (IGF2R), also known as cation-independent mannose 6-phosphate (M6P) receptor, is a transmembrane g

59 PMM converts mannose 6-phosphate (M6P) to mannose-1-phosphate, a prec

60 ke growth factor 2 (IGF2) and its inhibitor, mannose 6-phosphate (M6P)/IGF2 receptor (IGF2R), respect

61 bition assay was used to analyze whether the mannose 6-phosphate (M6P)/IGF2 receptor that also binds

62 The Tat motif allowed for mannose-6-phosphate (M6P) independent uptake in vitro an

63 Mannose-6-phosphate (M6P) is an essential precursor for

64 tional tagging with N-glycans terminating in mannose-6-phosphate (M6P) residues.

65 s the phosphomannomutase (Pmm) that converts mannose-6-phosphate (M6P) to mannose-1-phosphate (M1P).

66 We have determined the effect of applying Mannose-6-Phosphate (M6P), a scar reducing agent, to a s

67 Mannose-6-phosphate (M6P)-terminated oligosaccharides ar

68 Four VZV envelope glycoproteins contain mannose 6-phosphate (Man 6-P), and Man 6-P blocks infect

69 the CI-MPR (Dom1-3His) which contains both a mannose 6-phosphate (Man-6-P) and plasminogen binding si

70 e receptor (CI-MPR), which contains multiple mannose 6-phosphate (Man-6-P) binding sites that map to

71 e) deficiencies reduce the metabolic flux of mannose 6-phosphate (Man-6-P) into glycosylation, result

72 The mannose 6-phosphate (Man-6-P) lysosomal targeting signal

73 al receptor that binds to a diverse array of mannose 6-phosphate (Man-6-P) modified proteins as well

74 Two distinct mannose 6-phosphate (Man-6-P) receptors (MPRs), the cati

75 Nowhere is this better illustrated than the mannose 6-phosphate (Man-6-P) recognition system that me

76 non-lysosomal glycoproteins reported to bear mannose 6-phosphate (Man-6-P) residues on its N-glycans.

77 onlysosomal proteins have been shown to bear mannose 6-phosphate (Man-6-P) residues.

78 PMM converts mannose 6-phosphate (man-6-P) to mannose-1-phosphate (ma

79 which interconverts fructose 6-phosphate and mannose 6-phosphate (Man-6-P), used for glycoconjugate b

80 to the lysosome by binding newly synthesized mannose 6-phosphate (Man-6-P)-containing acid hydrolases

81 argeting system that binds newly synthesized mannose 6-phosphate (Man-6-P)-containing acid hydrolases

82 targeting system that bind newly synthesized mannose 6-phosphate (Man-6-P)-containing acid hydrolases

83 intracellular delivery of newly synthesized mannose 6-phosphate (Man-6-P)-containing acid hydrolases

84 Mannose 6-phosphate (Man-6-P)-dependent trafficking is v

85 oteins are delivered to the lysosome via the mannose 6-phosphate (Man-6-P)-targeting pathway.

86 specifically labels lysosomal proteins with mannose 6-phosphate (Man-6-P).

87 sferase, which tags lysosomal enzymes with a mannose 6-phosphate marker for transport to the lysosome

88 a linear relationship between the amount of mannose 6-phosphate measured and the amount of alpha-gal

89 in human fibrosarcoma cells, due to impaired mannose 6-phosphate modification.

90 hosphate receptor (IGF2R) include IGF-II and mannose 6-phosphate modified proteins.

91 n of insulin-like growth factor 2 (IGF2) and mannose 6-phosphate modified proteins.

92 Mannose 6-phosphate-modified N-glycans are the determina

93 and N255 glycosylation sites, which contain mannose-6-phosphate motifs important for I2S uptake into

94 sphomonoesters (Man-6-P) or phosphodiesters (mannose 6-phosphate N-acetylglucosamine ester, Man-P-Glc

95 The assay was also linear when measuring mannose 6-phosphate on electroblots.

96 nzyme replacement therapy are the absence of mannose 6-phosphate on recombinant human NAGLU and the b

97 wly synthesized lysosomal enzymes containing mannose 6-phosphate on their N-linked oligosaccharides.

98 e carbohydrate moieties, such as mannose and mannose 6-phosphate, on the enzymes.

99 arides harboring mono- and bisphosphorylated mannose 6-phosphates onto rhGAA (neo-rhGAA) significantl

100 The addition of mannose 6-phosphate or octyl glucoside, a nonionic deter

101 M6P and mannose 6-phosphate-poly[N-(2-hydroxyethyl)-acrylamide]

102 sorting nexin 1 (SNX1), as well as decreased mannose 6 phosphate receptor (M6PR), suggesting the impa

103 The cation-dependent mannose 6-phosphate receptor (CD-MPR) is a key component

104 The 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) plays a key role i

105 increased expression of the cation-dependent mannose 6-phosphate receptor (CD-MPR), which is partiall

106 on the trafficking of the cation-independent mannose 6-phosphate receptor (CI-M6PR).

107 ly recognize cargoes like cation-independent mannose 6-phosphate receptor (CI-MPR) and Insulin-like g

108 The 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR) and the 46 kDa cat

109 The 300-kDa cation-independent mannose 6-phosphate receptor (CI-MPR) and the 46-kDa cat

110 ii) Cells transduced with cation-independent mannose 6-phosphate receptor (CI-MPR) block apoptosis in

111 mplex, which recycles the cation-independent mannose 6-phosphate receptor (CI-MPR) from endosomes to

112 h the distribution of the cation-independent mannose 6-phosphate receptor (CI-MPR) has been well stud

113 The 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR) is a multifunction

114 The cation-independent mannose 6-phosphate receptor (CI-MPR) mediates sorting o

115 The 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR) mediates the intra

116 The 300-kDa cation-independent mannose 6-phosphate receptor (CI-MPR) plays a critical r

117 h affinity ligand for the cation-independent mannose 6-phosphate receptor (CI-MPR), and we analyzed t

118 The 300-kDa cation-independent mannose 6-phosphate receptor (CI-MPR), which contains mu

119 be because of inefficient cation-independent mannose 6-phosphate receptor (CI-MPR)-mediated endocytos

120 rk (TGN) transport of the cation-independent mannose 6-phosphate receptor (CI-MPR).

121 e cytoplasmic tail of the cation-independent mannose 6-phosphate receptor (CI-MPR).

122 erouted AP-1, endocytosed cation-independent mannose 6-phosphate receptor (CIMPR) accumulated in a pe

123 25 ArfGAPs for effects on cation-independent mannose 6-phosphate receptor (CIMPR) localization.

124 anges the distribution of cation-independent mannose 6-phosphate receptor (CIMPR) without affecting t

125 on-independent insulin-like growth factor-II/mannose 6-phosphate receptor (IGF-IIR) with IGFs and man

126 Ligands of the IGF-II/mannose 6-phosphate receptor (IGF2R) include IGF-II and

127 brane protein LIMP-2 has been a paradigm for mannose 6-phosphate receptor (MPR) independent lysosomal

128 fEndosome-to-Golgi retrieval of the mannose 6-phosphate receptor (MPR) is required for lysos

129 OCRL1 and IPIP27A localize to mannose 6-phosphate receptor (MPR)-containing traffickin

130 in maintaining Golgi structure and tethering mannose 6-phosphate receptor (MPR)-containing transport

131 R) on macrophages, ERT targets primarily the mannose 6-phosphate receptor (MPR).

132 he acid hydrolases to the cation-independent mannose 6-phosphate receptor allows sufficient sorting t

133 ecreased affinity for the cation-independent mannose 6-phosphate receptor and failed to bind to the c

134 itutive (transferrin receptor) and regulated mannose 6-phosphate receptor and GLUT4 trafficking to th

135 r, and low amounts of the cation-independent mannose 6-phosphate receptor and the lysosome-associated

136 e receptors including the cation-independent mannose 6-phosphate receptor and the mannose receptor.

137 gnition by the insulin-like growth factor II/mannose 6-phosphate receptor are predicted by sequence a

138 receptors, including the cation-independent mannose 6-phosphate receptor for lysosomal enzymes.

139 ates the retrieval of the cation-independent mannose 6-phosphate receptor from endosomes to the trans

140 the retrograde sorting of Cation-independent Mannose 6-Phosphate Receptor from late endosomes.

141 1 causes a mislocalization of both furin and mannose 6-phosphate receptor from the trans-Golgi networ

142 st time the three-dimensional structure of a mannose 6-phosphate receptor homology (MRH) domain prese

143 n, the N-terminal part of Yos9 including the mannose 6-phosphate receptor homology domain mediates th

144 Inactivation of the mannose 6-phosphate receptor homology domain of OS9 had

145 We postulate that the mannose 6-phosphate receptor homology domain of the gamm

146 trates that in the majority of instances the mannose 6-phosphate receptor homology domain of the gamm

147 lysosomal membranes, the accumulation of the mannose 6-phosphate receptor in and the recruitment of t

148 ired incorporation of the cation-independent mannose 6-phosphate receptor into clathrin-coated vesicl

149 These vesicles contain the mannose 6-phosphate receptor involved in targeting prote

150 The insulin-like growth factor II/mannose 6-phosphate receptor is a multifunctional recept

151 receptor tyrosine kinase, whereas the IGF-2/ mannose 6-phosphate receptor is a single transmembrane d

152 on the trafficking of the cation-independent mannose 6-phosphate receptor or the GLUT1 glucose transp

153 ficking of an endocytosed cation-independent mannose 6-phosphate receptor reporter from early endosom

154 All three GGAs (1, 2, and 3) bind to the mannose 6-phosphate receptor tail via their VHS domains,

155 six knockdowns cause the cation-independent mannose 6-phosphate receptor to become trapped in cluste

156 y sequence alignment to the cation-dependent mannose 6-phosphate receptor to reside within domains 3

157 for the retrieval of the cation-independent mannose 6-phosphate receptor to the TGN.

158 pe C cell membranes, which in turn, disrupts mannose 6-phosphate receptor trafficking.

159 nt that is independent of cation-independent mannose 6-phosphate receptor trafficking.

160 GA3 but not GGA2 bind the cation-independent mannose 6-phosphate receptor very poorly because of auto

161 eficient hepatocytes, whereas that of 46-kDa mannose 6-phosphate receptor was decreased to 30% of con

162 The steady-state level of 300-kDa mannose 6-phosphate receptor was slightly lower in LAMP-

163 uolar protein sorting 35 homolog), and M6PR (mannose 6-phosphate receptor) blocked PrP(C) internaliza

164 rs of transport vesicles (cation-independent mannose 6-phosphate receptor), late endosomes (Ras-assoc

165 nto cells via sortilin or cation-independent mannose 6-phosphate receptor, and facilitated the acidif

166 ach other and to the 46 kDa cation-dependent mannose 6-phosphate receptor, assemble into a compact st

167 argo, sortilin, SorLA and cation-independent mannose 6-phosphate receptor, in rodent primary neurons

168 fficking to the lysosome, presumably via the mannose 6-phosphate receptor, the 110-kDa precursor unde

169 membranes along with clathrin, giantin, the mannose 6-phosphate receptor, transferrin, and the early

170 tered distribution of the cation-independent mannose 6-phosphate receptor, which normally sorts acid

171 ilure of fission caused defective sorting of mannose 6-phosphate receptor, with consequently disrupte

172 r to that of avidin and the cation-dependent mannose 6-phosphate receptor, yet only domain 11 binds I

173 These results implicate MMR-independent and mannose 6-phosphate receptor-independent pathways in phL

174 o numerous ligands and plays a major role in mannose 6-phosphate receptor-independent transport of ly

175 Two such proteins, mannose 6-phosphate receptor-interacting protein TIP47 a

176 Here, we demonstrate that mannose 6-phosphate receptor-mediated cellular uptake an

177 6-phosphate, suggesting cation-independent, mannose 6-phosphate receptor-mediated endocytosis from t

178 enzyme is delivered to neonatal brain after mannose 6-phosphate receptor-mediated transcytosis.

179 tion, the induction of tolerance may require mannose 6-phosphate receptor-mediated uptake because alp

180 by repeated high doses of enzyme depends on mannose 6-phosphate receptor-mediated uptake or whether

181 r and failed to bind to the cation-dependent mannose 6-phosphate receptor.

182 protein had altered binding affinity for the mannose 6-phosphate receptor.

183 the bifunctional, IGF-II cation-independent mannose 6-phosphate receptor.

184 ecause of uptake of enzyme from blood by the mannose 6-phosphate receptor.

185 state localization of the cation-independent mannose 6-phosphate receptor.

186 rane proteins such as the cation-independent mannose 6-phosphate receptor.

187 ith high affinity for the cation-independent mannose 6-phosphate receptor.

188 e cytoplasmic tail of the cation-independent mannose 6-phosphate receptor.

189 ile ectopic expression of cation-independent mannose-6 phosphate receptor blocks apoptosis induced by

190 CD36, nitric oxide synthase type 2, and the mannose-6 phosphate receptor) that are known to be palmi

191 nclusion that the interacting protein is the mannose-6 phosphate receptor.

192 that are agonists of the cation-independent mannose-6-phosphate receptor (CI-M6PR).

193 tein NPC2, a cargo of the cation-independent mannose-6-phosphate receptor (CI-M6PR).

194 ograde trafficking of the cation-independent mannose-6-phosphate receptor (CI-MPR) and sortilin.

195 The cation-independent mannose-6-phosphate receptor (CI-MPR) follows a highly r

196 as been attributed to low cation-independent mannose-6-phosphate receptor (CI-MPR) in skeletal muscle

197 attributed to inefficient cation-independent mannose-6-phosphate receptor (CI-MPR) mediated uptake.

198 to-Golgi retrieval of the cation-independent mannose-6-phosphate receptor (CI-MPR), a receptor for ly

199 clenbuterol treatment on cation-independent mannose-6-phosphate receptor (CI-MPR)-mediated uptake an

200 tion between SNX5 and the cation-independent mannose-6-phosphate receptor (CI-MPR).

201 lls, both the late autophagy pathway and the mannose-6-phosphate receptor (M6PR) pathway are interrup

202 -like growth factor-II receptor (IGF-IIR), a mannose-6-phosphate receptor (M6PR) that binds to cathep

203 alization of specific cargo proteins (furin, mannose-6-phosphate receptor (M6PR), and M6PR lacking a

204 II (IGF2) enhances memory in rodents via the mannose-6-phosphate receptor (M6PR), but the underlying

205 Uptake of recombinant enzyme is via the mannose-6-phosphate receptor (M6PR).

206 y transient but dramatic upregulation of the mannose-6-phosphate receptor (MPR) on the tumor cell sur

207 endosomal membranes as that followed by the mannose-6-phosphate receptor (MPR), and consistent with

208 oteins such as furin, the cation-independent mannose-6-phosphate receptor and in viral proteins such

209 of cargoes, including the cation-independent mannose-6-phosphate receptor and semaphorin 4C, by the m

210 mes to the TGN, but not for the retrieval of mannose-6-phosphate receptor from late endosomes.

211 tracellular region of the cation-independent mannose-6-phosphate receptor has gained an IGF-II-bindin

212 is an ER-resident glycoprotein containing a mannose-6-phosphate receptor homology domain, which is a

213 nked dimer, the majority is directed via the mannose-6-phosphate receptor pathway to endocytic compar

214 ts and control Rab9-dependent trafficking of mannose-6-phosphate receptor to lysosomes.

215 Cation-independent mannose-6-phosphate receptor, also called insulin-like g

216 l G-proteins, including Ras, up-regulate the mannose-6-phosphate receptor, and induce apoptosis.

217 d lysosomal marker proteins, including Rab7, mannose-6-phosphate receptor, and LAMP-1.

218 or (IGF2R), also known as cation-independent mannose-6-phosphate receptor, which is involved in traff

219 47 kDa (TIP47; also known as perilipin-3 and mannose-6-phosphate receptor-binding protein 1), a membe

220 The enzyme is delivered by a mannose-6-phosphate receptor-dependent mechanism to the

221 ces, and can be taken up by distal cells via mannose-6-phosphate receptor-mediated endocytosis.

222 argeted to the lysosome independently of the mannose-6-phosphate receptor.

223 glycosaminoglycans and a cation-independent mannose-6-phosphate receptor.

224 2 chimera containing a cytosolic domain of a mannose-6-phosphate receptor.

225 ng the basis for lysosomal transport via the mannose-6-phosphate receptor.

226 of endo-lysosomes, as well as impairment of mannose-6-phosphate-receptor trafficking.

227 ity of the cation-independent and -dependent mannose 6-phosphate receptors (CI-MPR and CD-MPR) for hi

228 n cell lines deficient in cation-independent mannose 6-phosphate receptors (MPRci).

229 the cation-dependent and cation-independent mannose 6-phosphate receptors (MPRs) and is required for

230 olgi network (TGN) is mediated by binding to mannose 6-phosphate receptors (MPRs) and subsequent capt

231 in a late endosome microdomain together with mannose 6-phosphate receptors (MPRs) and the tail-intera

232 Mannose 6-phosphate receptors (MPRs) are transported fro

233 Mannose 6-phosphate receptors (MPRs) are transported fro

234 n-independent (CI) and cation-dependent (CD) mannose 6-phosphate receptors (MPRs) bind specifically t

235 Mannose 6-phosphate receptors (MPRs) deliver lysosomal h

236 Mannose 6-phosphate receptors (MPRs) deliver newly synth

237 ns (GGAs) are multidomain proteins that bind mannose 6-phosphate receptors (MPRs) in the Golgi and ha

238 Mannose 6-phosphate receptors (MPRs) participate in the

239 olases to lysosomes relies on transmembrane, mannose 6-phosphate receptors (MPRs) that cycle between

240 is required for Rab9-dependent recycling of mannose 6-phosphate receptors (MPRs) to the Golgi and fo

241 was taken up by a combination of mannose and mannose 6-phosphate receptors (MR and M6PR, respectively

242 chinery that mediates the trafficking of the mannose 6-phosphate receptors and associated cargo from

243 ow visualization of endocytosis of mod2B via mannose 6-phosphate receptors and delivery of mod2B to l

244 s of GCC185 triggers enhanced degradation of mannose 6-phosphate receptors and enhanced secretion of

245 s Rab9 GTPase and the cytoplasmic domains of mannose 6-phosphate receptors and is required for their

246 rectly leads to impaired recycling of 46-kDa mannose 6-phosphate receptors and partial mistargeting o

247 Cation-independent mannose 6-phosphate receptors are enriched in the Rab9 d

248 targeted to the lysosome through binding to mannose 6-phosphate receptors because their glycans are

249 TIP47 functions in the delivery of mannose 6-phosphate receptors from endosomes to the tran

250 ab9A and its effectors regulate recycling of mannose 6-phosphate receptors from late endosomes to the

251 ab9A and its effectors regulate transport of mannose 6-phosphate receptors from late endosomes to the

252 ated cholesterol on Rab9-dependent export of mannose 6-phosphate receptors from this compartment.

253 However, mutant PPT enzymes did not bind to mannose 6-phosphate receptors in a blotting assay.

254 two proteins may cooperate in packaging the mannose 6-phosphate receptors into clathrin-coated vesic

255 h-muscle cell interaction may be mediated by mannose 6-phosphate receptors present on monocytes.

256 ck in Rab6-dependent retrograde transport of mannose 6-phosphate receptors to the Golgi.

257 This blocks retrieval of mannose 6-phosphate receptors to the TGN and impairs cat

258 n-Pick type C membranes, as cation-dependent mannose 6-phosphate receptors were missorted to the lyso

259 the surface expression or internalization of mannose 6-phosphate receptors, which are required for VZ

260 osis of lysosomal enzymes via the mannose or mannose 6-phosphate receptors.

261 upstream of the steady-state distribution of mannose 6-phosphate receptors.

262 tifs present in the cytoplasmic tails of the mannose 6-phosphate receptors.

263 the cation-independent and cation-dependent mannose 6-phosphate receptors.

264 the cation-independent and cation-dependent mannose 6-phosphate receptors.

265 e, resulting in the peripheral dispersion of mannose 6-phosphate receptors.

266 -phosphate, indicating lysosomal sorting via mannose 6-phosphate receptors.

267 ome-to-Golgi retrieval of cation-independent mannose-6-phosphate receptors (CI-MPR) in the soma is di

268 reduced in hydrolytic enzymes transported by mannose-6-phosphate receptors (MPRs).

269 This protein was known to transport mannose-6-phosphate receptors from endosome to trans-Gol

270 etwork to lysosomes and the incorporation of mannose-6-phosphate receptors into CCVs.

271 This effect was mediated via upregulation of mannose-6-phosphate receptors on the surface of tumor ce

272 trast to wild-type ASA, which is taken up by mannose-6-phosphate receptors, all chimeric proteins wer

273 the cation-independent and cation-dependent mannose-6-phosphate receptors, are recognized by the GGA

274 delivery was independent of high-mannose and mannose-6-phosphate receptors, which are exploited for d

275 1 reaches the vacuole even in the absence of mannose-6-phosphate receptors, which are responsible for

276 human GGA3 complexed with signals from both mannose-6-phosphate receptors.

277 iates the first step in the synthesis of the mannose 6-phosphate recognition marker on acid hydrolase

278 iates the first step in the synthesis of the mannose 6-phosphate recognition marker on lysosomal acid

279 oves a covering N-acetylglucosamine from the mannose 6-phosphate recognition marker on lysosomal acid

280 iates the first step in the synthesis of the mannose 6-phosphate recognition marker on lysosomal acid

281 yzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal enzy

282 sents the key enzyme for the biosynthesis of mannose 6-phosphate recognition marker on soluble lysoso

283 ags newly synthesized lysosomal enzymes with mannose 6-phosphate recognition markers, which are requi

284 tes the initial step in the formation of the mannose 6-phosphate recognition signal on lysosomal acid

285 GlcNAc-1-phosphotransferase, which generates mannose 6-phosphate residues on lysosomal enzymes.

286 e, the initial enzyme in the biosynthesis of mannose 6-phosphate residues, is governed by a common pr

287 d medaka does not appear to be modified with mannose 6-phosphate residues.

288 osaccharides with both terminal mannosyl and mannose 6-phosphate residues.

289 , an enzyme involved in the synthesis of the mannose 6-phosphate signal that targets acid hydrolases

290 These genes encode enzymes that generate the mannose-6-phosphate signal, which directs a diverse grou

291 sport of ARSG in the liver is independent of mannose 6-phosphate, sortilin, and Limp2.

292 urable and can be competitively inhibited by mannose 6-phosphate, suggesting cation-independent, mann

293 These hydrolases acquire a mannose 6-phosphate tag by the action of the GlcNAc-1-ph

294 ates the initial step in the addition of the mannose 6-phosphate targeting signal on newly synthesize

295 ng yolk utilization and the evolution of the mannose 6-phosphate targeting system in vertebrates.

296 der caused by defects in the biosynthesis of mannose 6-phosphate, the carbohydrate recognition signal

297 aining glycoconjugates, is the conversion of mannose-6-phosphate to mannose-1-phosphate, by a phospho

298 6-phosphate and quantitation of the released mannose 6-phosphate using HPAEC with PAD.

299 ribose-5-phosphate, glucose-6-phosphate, and mannose-6-phosphate was achieved by UPLC/multiple-reacti

300 to residue N325, and that it binds MPR, via mannose 6-phosphate, with a similar affinity to that obs