ライフサイエンスコーパス: mannose-binding lectin

1 ding protein, as well as to a novel partner, mannose-binding lectin.

2 -binding lectins A and C, or in both C1q and mannose-binding lectins.

3 ype 1 transmembrane protein with homology to mannose-binding lectins.

4 PLN included genes encoding proteins such as mannose binding lectin 1, lysozyme, alpha-1 catenin, cad

5 Mannose binding lectin 2 and pentraxin-3 (PTX3), two act

6 pulmonary and circulating opsonins, SP-D and mannose binding lectin 2, respectively.

7 variants of inflammatory mediators, such as mannose-binding lectin 2 (MBL2), are associated with col

8 sociations were observed for two SNPs in the mannose-binding lectin 2 (ML2) gene and risk of glioma (

9 reviously studied modifier genes, coding for mannose-binding lectin 2 and TGF-beta1, influence pulmon

10 and regulated complement activation through mannose-binding lectin 2.

11 The variant alleles in the mannose binding lectin-2 (MBL-2) gene have been associat

12 The frequency of the mannose-binding lectin-2 codon 54 allele was significant

13 14 [336.2] ng/mL vs 1826 [541.0] ng/mL), and mannose-binding lectin (79.4 [12.4] ng/mL vs 69.6 [14.7]

14 To examine the physiological functions of mannose-binding lectin A (MBL-A), we generated mice that

15 mice genetically deficient in either C1q or mannose-binding lectins A and C, or in both C1q and mann

16 his novel pathway is specific to C1q because mannose-binding lectin, a related collectin, failed to u

17 To investigate the role of mannose-binding lectin-A (MBL-A) in protection against i

18 controlled cortical impact using anti-mouse mannose-binding lectin-A and mannose-binding lectin-C an

19 ose-binding lectin deletion in wild-type and mannose-binding lectin-A and mannose-binding lectin-C do

20 The extent of mannose-binding lectin-A expression was lower when compa

21 The reduced sequelae associated with mannose-binding lectin absence suggest that mannose-bind

22 Mannose binding lectin and lung surfactant protein A, ot

23 for surface-coated mannose derivatives with mannose binding lectins and antibodies.

24 sical pathway with little contributions from mannose-binding lectin and alternative pathways.

25 levels of mannose-binding lectin and C1q-C4 were measured to exami

26 Posttransplant serum mannose-binding lectin and classical pathway activity an

27 ns that are structurally homologous to SP-A, mannose-binding lectin and complement protein 1q, did no

28 noglobulin G may induce association with the mannose-binding lectin and contribute to the pathology.

29 codon 52 was associated with a low level of mannose-binding lectin and impaired mannose-binding lect

30 binding of the key lectin pathway components mannose-binding lectin and mannose-binding lectin-associ

31 Systematic reviews of procalcitonin, mannose-binding lectin and molecular amplification techn

32 Other collectins, such as mannose-binding lectin and the collectin-like C1q, have

33 c organelles of adhesion composed of FimH, a mannose-binding lectin, and a shaft composed primarily o

34 cific ICAM-3-grabbing nonintegrin (DC-SIGN), mannose-binding lectin, and heparan sulfate, enhance the

35 served also to known endogenous ligands C1q, mannose-binding lectin, and secretory IgA.

36 e component of the innate immune system, the mannose-binding lectin, and Toll-like receptor 2 that bo

37 etic peptide], TSP2 [thrombospondin-2], MBL [mannose-binding lectin]; and 3 with lower risk: ErbB1 [e

38 Using anti-human mannose-binding lectin antibody, we evaluated mannose-bi

39 3 activation when C4 or C1q, or both C1q and mannose-binding lectins, are absent.

40 We have tested the application of high-mannose-binding lectins as analytical reagents to identi

41 d to activation of the complement pathway by mannose-binding lectin, as suggested by in vitro studies

42 The mannose-binding lectin associated-protease-3 (MASP-3) is

43 the C1s protease (classical pathway) or the mannose-binding lectin-associated serine protease (MASP)

44 The serum of mannose-binding lectin-associated serine protease (MASP)

45 Until now the autoactivating mannose-binding lectin-associated serine protease (MASP)

46 In resting blood, mannose-binding lectin-associated serine protease 3 (MAS

47 ne-targeted mice deficient in the complement mannose-binding lectin-associated serine protease-1 and

48 in-2, ficolin-3, collectin-10, collectin-11, mannose-binding lectin-associated serine protease-1, and

49 athway components mannose-binding lectin and mannose-binding lectin-associated serine protease-2 (MAS

50 ing lectin-associated serine protease-1, and mannose-binding lectin-associated serine protease-2.

51 binds DNA more effectively than do SP-A and mannose-binding lectin at physiological salt conditions.

52 In addition to ligands for galectins and mannose-binding lectins, azido functionality could be re

53 ed by the collectins surfactant protein D or mannose binding lectin because of a paucity of glycan at

54 Mannose-binding lectins bind to rough variants, but lect

55 Mannose-binding lectin bound avidly to G0 IgG, but lecti

56 In contrast, the collectin mannose binding lectin C (MBL-C) but not MBL-A led to ef

57 sing anti-mouse mannose-binding lectin-A and mannose-binding lectin-C antibodies.

58 n wild-type and mannose-binding lectin-A and mannose-binding lectin-C double-knockout mice.

59 Similarly in mice, we observed mannose-binding lectin-C-positive immunoreactivity in th

60 ression was lower when compared with that of mannose-binding lectin-C.

61 Deposits of C4d, mannose-binding lectin, C1q, IgM, and C5b-9 were scored

62 3, C4, factor B (fB), factor properdin (fP), mannose-binding lectin, C3aR, C5aR, or Ig and assessed r

63 Mannose-binding lectin, C4b, CFI, C5, and sC5b9 were neg

64 extracts of kidney bean and hyacinth bean a mannose-binding lectin, called FRIL, and provide here ev

65 attern-recognition molecules such as C1q and mannose-binding lectin can trigger complement activation

66 in the genes of several Toll-like receptors, mannose-binding lectin, CD14, killer immunoglobulin-like

67 The labels were recognized by the mannose-binding lectin, Con A, and the biotin-binding pr

68 oteins (SPs) SP-A and SP-D and serum protein mannose-binding lectin, could recognize nucleic acids, p

69 Mannose-binding lectin deficiency (defined as a mannose-

70 An association between mannose-binding lectin deficiency and anti-Saccharomyces

71 ts with systemic lupus erythematosus who had mannose-binding lectin deficiency associated with homozy

72 We evaluated the effects of mannose-binding lectin deletion in wild-type and mannose

73 cortical impact and (2) to evaluate whether mannose-binding lectin deletion is associated with reduc

74 f the Escherichia coli that is composed of a mannose-binding lectin domain and a fimbria-incorporatin

75 nism of bacterial cell attachment, where the mannose-binding lectin domain switches from an 'inactive

76 s of a fimbria-associated pilin domain and a mannose-binding lectin domain, with the binding pocket p

77 ng (pilin) domain of FimH interacts with the mannose-binding (lectin) domain and causes a twist in th

78 ion of Salmonella-specific antibody, but not mannose-binding lectin, enabled NTS killing.

79 Human ficolin 2 (encoded by FCN2) and mannose-binding lectin (encoded by MBL2) bind to specifi

80 Goals were (1) to investigate mannose-binding lectin expression after human and experi

81 annose-binding lectin antibody, we evaluated mannose-binding lectin expression in tissue samples from

82 Mannose-binding lectin expression was documented after t

83 Mannose-binding lectin, Ficolin-1, and Ficolin-3 were me

84 ited because of the efficient degradation of mannose-binding lectin, ficolin-2, ficolin-3, and C4 by

85 ent pathways due to efficient degradation of mannose-binding lectin, ficolin-2, ficolin-3, and C4, wh

86 the lectin pathway of complement activation: mannose-binding lectin, ficolin-2, ficolin-3, collectin-

87 nd might have superior properties over other mannose binding lectins for this purpose.

88 ds coated with the broad-spectrum opsonin Fc-mannose-binding lectin for the magnetic capture of patho

89 Mannose-binding protein (MBP; mannose-binding lectin) forms part of the innate immune

90 um concentrations of mannose-binding lectin, mannose-binding lectin functional activity, MBL2 and NOD

91 Genetic polymorphisms in the mannose-binding lectin gene, a key activator in the lect

92 gated the effect of genetic variation in the mannose-binding lectin gene, MBL2, on susceptibility and

93 (-/-) mice, whereas deficiency of C4, Ig, or mannose-binding lectin had no effect.

94 mannose-binding protein (MBP; also known as mannose-binding lectin) have been revealed by introducti

95 Carbohydrate-binding proteins, particularly mannose-binding lectins, have also been shown to bind th

96 Anti-PLA2R1 IgG4 directly bound mannose-binding lectin in a glycosylation-dependent mann

97 tion of Fc receptors in donor macrophages or mannose-binding lectin in recipient mice failed to rescu

98 LP) might play a more dominant role than the mannose-binding lectin-lectin pathway in the pathomechan

99 nose-binding lectin deficiency (defined as a mannose-binding lectin level of <500 ng/mL) did not infl

100 Golgi transport through interaction with the mannose-binding lectin LMAN1.

101 relationship between serum concentrations of mannose-binding lectin, mannose-binding lectin functiona

102 level of mannose-binding lectin and impaired mannose-binding lectin-mannose-associated serine proteas

103 Mannose binding lectin (MBL) is a central component of t

104 ) and the carbohydrate recognition domain of mannose binding lectin (MBL) to target native HIV Env (C

105 Here we provide evidence that C1q and mannose binding lectin (MBL), a member of the collectin

106 high bacterial diversity leads to increased mannose binding lectin (MBL), IgM, IgG, C3b, C5, IL-8, I

107 Here we focused on mannose binding lectin (MBL), which is one of several pr

108 gland protein that inhibits the function of Mannose Binding Lectin (MBL).

109 tation is found in the collagenous domain of mannose binding lectin (MBL).

110 Serum factors, including mannose binding lectins (MBL), influence innate response

111 novel mouse that expresses functional human mannose-binding lectin (MBL) 2 under the control of Mbl1

112 Mannose-binding lectin (MBL) activates the lectin pathwa

113 We now demonstrate that the serum collectins mannose-binding lectin (MBL) and conglutinin have less a

114 lement pathway activation molecules comprise mannose-binding lectin (MBL) and ficolin-1, -2, and -3 i

115 In the lectin pathway, mannose-binding lectin (MBL) and ficolins bind to pathog

116 to human fecal microbiota using the soluble mannose-binding lectin (MBL) and intelectin-1 (hItln1).

117 to the lectin complement pathway, including mannose-binding lectin (MBL) and its associated proteins

118 ng from acute hyperglycemia are dependent on mannose-binding lectin (MBL) and lectin complement pathw

119 te recognition domains (CRDs) of human serum mannose-binding lectin (MBL) and pulmonary surfactant pr

120 The collectins mannose-binding lectin (MBL) and surfactant protein D (S

121 Collectins such as mannose-binding lectin (MBL) and surfactant protein D (S

122 The role of mannose-binding lectin (MBL) and the lectin complement p

123 Oxidative stress increases endothelial mannose-binding lectin (MBL) binding and activates the l

124 In this study, we provide evidence that mannose-binding lectin (MBL) binds to beta2-GPI in Ca(++

125 PRMs tested, the long pentraxin 3 (PTX3) and mannose-binding lectin (MBL) bound the viral nucleocapsi

126 Mannose-binding lectin (MBL) deficiency is associated wi

127 C1q/mannose-binding lectin (MBL) double-deficient mice, howe

128 Mannose-binding lectin (MBL) enhances opsonization and a

129 in pathway as well as interaction of IgM and mannose-binding lectin (MBL) in pig-to-human xenotranspl

130 Mannose-binding lectin (MBL) is a circulating immune fac

131 Mannose-binding lectin (MBL) is a circulating serum prot

132 Mannose-binding lectin (MBL) is a humoral pattern-recogn

133 Mannose-binding lectin (MBL) is a key component of innat

134 Mannose-binding lectin (MBL) is a key mediator of innate

135 Mannose-binding lectin (MBL) is a pattern-recognition mo

136 Human mannose-binding lectin (MBL) is a serum protein of the i

137 Mannose-binding lectin (MBL) is a serum protein that pla

138 Mannose-binding lectin (MBL) is an evolutionarily conser

139 The mannose-binding lectin (MBL) is an evolutionary conserve

140 Mannose-binding lectin (MBL) is an important complement-

141 Mannose-binding lectin (MBL) is an important component o

142 Mannose-binding lectin (MBL) is an integral part of the

143 Mannose-binding lectin (MBL) is an oligomeric plasma pro

144 pecifically C1q of the classical pathway and mannose-binding lectin (MBL) of the lectin pathway.

145 The deposition of complement components and mannose-binding lectin (MBL) on the bacterial surface wa

146 The influence of the innate immune protein mannose-binding lectin (MBL) on the response of human ph

147 with an overall structure similar to C1q and mannose-binding lectin (MBL) participate in microbe infe

148 pathway of activation leading to injury, the mannose-binding lectin (MBL) pathway might also play a c

149 The mannose-binding lectin (MBL) pathway of the complement c

150 Mannose-binding lectin (MBL) plays a key role in the act

151 Human mannose-binding lectin (MBL) provides a first line of de

152 Mannose-binding lectin (MBL) targets diverse microorgani

153 The mannose-binding lectin (MBL), a circulating pattern reco

154 The in vivo impact of mannose-binding lectin (MBL), a molecule involved in inn

155 We postulate that genetic variants of mannose-binding lectin (MBL), a plasma opsonin that init

156 Mannose-binding lectin (MBL), a soluble mediator of inna

157 genes encoding tumor necrosis factor (TNF), mannose-binding lectin (MBL), and Fcgamma receptor IIa (

158 Binding of complement factors C3b, IgM, C1q, mannose-binding lectin (MBL), and properdin to LDL and a

159 C1q, mannose-binding lectin (MBL), and pulmonary surfactant p

160 The complement protein C1q, mannose-binding lectin (MBL), and pulmonary surfactant p

161 tive pathway factor D and Bb, lectin pathway mannose-binding lectin (MBL), and shared neurotoxic effe

162 The innate immune mediator, mannose-binding lectin (MBL), enhances phagocytosis of p

163 We investigated the binding of the PRMs mannose-binding lectin (MBL), ficolin-1, ficolin-2, and

164 CP), which is initiated by deposition of the mannose-binding lectin (MBL), is largely responsible for

165 We investigated the roles of C1q and mannose-binding lectin (MBL), key pattern recognition mo

166 Here, we document the pivotal role of mannose-binding lectin (MBL), one of the recognition mol

167 reased amounts in rheumatoid arthritis, bind mannose-binding lectin (MBL), providing a potential rout

168 nd function of the innate humoral component, mannose-binding lectin (MBL), was investigated.

169 It was investigated whether a deficiency of mannose-binding lectin (MBL), which binds Aspergillus sp

170 We also discovered that ligation of mannose-binding lectin (MBL), which binds to glycans of

171 acity to activate the complement pathway via mannose-binding lectin (MBL), which could contribute to

172 ontitis increases the serum concentration of mannose-binding lectin (MBL), which exacerbates local in

173 es and serum factors, such as complement and mannose-binding lectin (MBL), which is a broad-spectrum

174 trated in germinal centers in a complement-, mannose-binding lectin (MBL)-, and immunogen glycan-depe

175 ads coated with an engineered human opsonin--mannose-binding lectin (MBL)--that captures a broad rang

176 Individuals with serum deficient in mannose-binding lectin (MBL)-an important component of t

177 allenged when it was shown that mice lacking mannose-binding lectin (MBL)-associated serine protease-

178 erminal complement complex was observed with mannose-binding lectin (MBL)-deficient serum.

179 In contrast, mannose-binding lectin (MBL)-null and MBL-associated ser

180 Thus, we hypothesized that the endogenous mannose-binding lectin (MBL)/ficolin-associated protein-

181 Mannose-binding lectin (MBL)/ficolin/collectin-11-associ

182 TcCalr binds and inactivates C1 and mannose-binding lectin (MBL)/ficolins, important pattern

183 ch as surfactant protein-A (SP-A), SP-D, and mannose-binding lectin (MBL); phagocyte cytokines, such

184 or lectin pathway, with the latter requiring mannose-binding lectin (MBL, also known as mannose-bindi

185 The mannose-binding lectin (MBL, also known as mannose-bindi

186 Mannose-binding lectin (MBL-2) allele variants are assoc

187 The mannose-binding lectin (MBL; also termed "mannose-bindin

188 even candidate genes (myeloperoxidase [MPO], mannose binding lectin [MBL], Fcgamma receptors IIa, III

189 In mammals, collectin family members (e.g., mannose-binding lectin [MBL]) and the structurally relat

190 immunity to Giardia using mice deficient in mannose-binding lectin (Mbl2) or complement factor 3a re

191 r 1; Lipopolysaccharide binding protein-LBP; Mannose-binding lectin-MBL2; Myeloperoxidase-PERM and Se

192 Various recombinant mannose binding lectins (MBLs) and MBLs in sera of both

193 tly in three separate protein families, C1q, mannose-binding lectins (MBLs), and serum ficolins.

194 n C3 or IgG FcRs excluded the implication of mannose-binding lectin-mediated complement activation in

195 Binding of NS1 to MBL protects DENV against mannose-binding lectin-mediated neutralization by the le

196 observed attenuated sensorimotor deficits in mannose-binding lectin (-/-) mice compared with wild-typ

197 cortical cell loss at 5 weeks postinjury in mannose-binding lectin (-/-) mice compared with wild-typ

198 mannose-binding lectin absence suggest that mannose-binding lectin modulation might be a potential t

199 an FRIL shows 78% amino acid identity with a mannose-binding lectin of hyacinth beans.

200 ially important interaction of FL cells with mannose-binding lectins of the innate immune system.

201 ound with a model influenza vaccine, such as mannose-binding lectin opsonization of influenza and upt

202 No associations between mannose-binding lectin or Ficolin-1 and graft loss were

203 immune response, whereas the alternative and mannose-binding lectin pathways are activated directly b

204 ntribution compared with the alternative and mannose-binding lectin pathways has not been defined.

205 ecific carbohydrate recognition subcomponent mannose-binding lectin plays an essential role in the pa

206 ng human traumatic brain injury, we observed mannose-binding lectin-positive immunostaining in the in

207 Additionally, high-mannose-binding lectins possess a broad capacity to neut

208 A few mannose-binding lectins potently inactivate HIV but have

209 Mannose-binding lectin protein is the activator of the l

210 We found that mannose binding lectins, proteins naturally present in t

211 e absence of the endocytic Mrc1 (MMR, CD206) mannose-binding lectin receptor.

212 cently shown that collectins SP-A, SP-D, and mannose binding lectin recognize DNA and RNA via their c

213 IgG1kappa isotypes) were raised against rat mannose-binding lectin (rMBL).

214 mannose-binding protein (MBP, also known as mannose-binding lectin) show increased susceptibility to

215 Similar to C1q and mannose-binding lectin, SP-A and SP-D bound to apoptotic

216 imannosidic proteins displayed affinities to mannose-binding lectin, suggesting immune-related functi

217 Cyanovirin-N (CV-N) is a mannose-binding lectin that inhibits HIV-1 infection by

218 Specifically, the mannose-binding lectins that best agglutinate glycodendr

219 Mannose-binding lectin, together with mannose-associated

220 lupus erythematosus who were homozygous for mannose-binding lectin variant alleles had a fourfold in

221 lectin deficiency associated with homozygous mannose-binding lectin variant alleles.

222 Carbohydrate recognition by monocot mannose-binding lectins was studied via the crystal stru

223 ependent on the recruitment of either C1q or mannose-binding lectin, which are both early complement

224 s is dependent on the recruitment of C1q and mannose-binding lectin, which have known immune modulato

225 MBL2 encodes the mannose-binding lectin, which is a key player in the inn