ライフサイエンスコーパス: mannosyl

1 provided for the intermediacy of benzylidene mannosyl 1,3-dioxanium ions, while the formation of the

2 und that alpha-mannnosyl1-3 (6'-O-acyl alpha-mannosyl)-1-1 monoacylglycerol and cholesteryl 6'-O-acyl

3 a urea transporter, Ca(2+) :H(+) antiporter, mannosyl-3-phosphoglycerate synthase and phosphatase, DN

4 The glycosyltransferase gene, mannosyl (alpha-1,3-)-glycoprotein beta-1,2- N-acetylglu

5 Deletion of the mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylgluc

6 ansferase 7 (beta3GnT7), Mgat5, and possibly mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylgluc

7 NGT occurs in close proximity to mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetylgluc

8 e first time close proximity between NGT and mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetylgluc

9 s yet perfectly controlled displays of alpha-mannosyl (alpha-Man) and beta-lactosyl (beta-Lact) anten

10 mpounds have been obtained by coupling alpha-mannosyl and alpha-N-acetyl-glucosamine phosphoramidite

11 and Selaginella showed they were composed of mannosyl and glucosyl residues and the mannosyl residues

12 contain oligosaccharides with both terminal mannosyl and mannose 6-phosphate residues.

13 good anomeric selectivity was observed with mannosyl and rhamnosyl PPG donors.

14 rates a specific N-glycan structure of seven mannosyl and two N-acetylglucosamine residues (Man7GlcNA

15 ated donor on O3 is a highly alpha-selective mannosyl and, after radical fragmentation, alpha-d-rhamn

16 by an endo-beta-N-acetylglucosaminidase, the mannosyl arms are trimmed by the cooperative action of t

17 However, the mycobacterial lipid antigen mannosyl-B1-phosphomycoketide (MPM) may be processed thr

18 structure precisely corresponds to mammalian mannosyl beta-1-phosphodolichol (MPD), but contains an u

19 Responses to mannosyl-beta1-phosphodolichols were common among CD1c-r

20 -phosphoisoprenoids and structurally related mannosyl-beta1-phosphodolichols.

21 athogenic Mycobacterium tuberculosis antigen mannosyl-beta1-phosphomycoketide (MPM).

22 tide (PM) shows similarities to that of CD1c-mannosyl-beta1-phosphomycoketide in that the A' pocket a

23 ted approximately 6 A in relation to that of mannosyl-beta1-PM.

24 hed glycans, but its ability to synthesize O-mannosyl-branched glycans is unknown; conversely, althou

25 SP-A monoclonal antibodies and by the use of mannosyl-BSA, which blocked the suppression of RNI level

26 tereoselectivity of the desired beta-allyl-C-mannosyls by moving to a sulfoxide mannosyl donor, which

27 The development of a positive charge at mannosyl C1, as the oxocarbenium-like transition state i

28 f this compound with mannose caps (producing mannosyl-capped LAM [ManLAM]) in M. tuberculosis or with

29 The extensive mannosyl capping of arabinose termini of ManLAM may unde

30 ntermediate oxocarbenium ions, including the mannosyl cation, as well as consideration of steric effe

31 Except for a moderate enrichment of mannosyl compounds and glycogen, heterozygous mice were

32 ups of hepatocytes with increased content of mannosyl compounds and glycogen, some of them undergoing

33 of newly raised antibodies specific for an O-mannosyl-conjugated epitope revealed that these glycans

34 The building block for the mannosyl constituents of these components is GDP-mannose

35 nversion of beta1,4-mannobiose to 4-O-beta-d-mannosyl-d-glucose in mannan metabolism.

36 WbdD phosphorylates 2-alpha-d-mannosyl-d-mannose (2alpha-MB), a short mimic of the O9a

37 peptide synthesis methods, two units of the mannosyl derivative 1 (shown as L-Tyr[C-Ac(4)-alpha-D-Ma

38 ) mixture of isosulfan blue and (99m)Tc-DTPA-mannosyl-dextran (7.4 MBq, 0.3 nmol).

39 d colonic submucosal injection, (99m)Tc-DTPA-mannosyl-dextran demonstrated high sentinel node uptake

40 Tc-Diethylenetriaminepentaacetic acid (DTPA)-mannosyl-dextran is a new radiotracer labeled with (99m)

41 (99m)Tc-DTPA-mannosyl-dextran uptake by colonic sentinel nodes (n = 4

42 To test this model, we disrupted IPT1, the mannosyl-diinositolphosphoryl-ceramide synthase of S. ce

43 and sec14-1(ts) sac1-22 strains showed that mannosyl-diinositolphosphoryl-ceramide synthesis was not

44 nthesis and, in particular, the synthesis of mannosyl-diinositolphosphoryl-ceramide with concomitant

45 hosphatidylinositol 4-phosphate, rather than mannosyl-diinositolphosphoryl-ceramide, accumulates in t

46 e, this study provides a complete picture of mannosyl dioxanium ion formation.

47 for mannosylinositol phosphorylceramides or mannosyl diphosphoinositol ceramides on growth and viabi

48 GDP-Man, the mannosyl donor for most Man-containing polymers is forme

49 ichol-phosphate mannose (Dol-P-Man) is a key mannosyl donor for the biosynthesis of N-linked oligosac

50 The critical mannosyl donor for these reactions is the nucleotide sug

51 n transfer of Man from GDPMan to Dol-P, is a mannosyl donor in pathways leading to N-glycosylation, g

52 doplasmic reticulum (ER), and functions as a mannosyl donor in the biosynthesis of Glc(3)Man(9)GlcNAc

53 The activation of this polymer-supported mannosyl donor is achieved at -60 degrees C in dichlorom

54 a-allyl-C-mannosyls by moving to a sulfoxide mannosyl donor, which could be activated at low temperat

55 n analogue (C7) of the benzylidene-protected mannosyl donor, which is investigated in terms of diaste

56 2,3-di-O-benzyl-4, 6-O-benzylidene protected mannosyl donors and draw attention to the subtle interpl

57 he C2-O2 and C3-O3 bonds in the glucosyl and mannosyl donors and of the influence of this interaction

58 4-trifluoromethylbenzenepropargyl)-protected mannosyl donors are extremely beta-selective.

59 Mannosyl donors were highly alpha-selective despite the

60 ing 4,6-O-benzylidene-protected glucosyl and mannosyl donors, which are alpha- and beta-selective, re

61 by means of 4,6-O-benzylidene-protected beta-mannosyl donors.

62 n systems involving benzylidene glucosyl and mannosyl donors.

63 ined starting from imidazolium cation-tagged mannosyl fluoride and thiomannoside using block coupling

64 cNAc transfer activity toward N-linked and O-mannosyl glycan core structures and that its brain-speci

65 Here, we show that O-mannosyl glycan epitopes recognized by these antibodies

66 at-315 and 3F8 were demonstrated to detect O-mannosyl glycan modifications on RPTPzeta/phosphacan.

67 which is reported to be the most abundant O-mannosyl glycan on alpha-DG.

68 l analyses, we identified a phosphorylated O-mannosyl glycan on the mucin-like domain of recombinant

69 in and establish a functional link between O-mannosyl glycans and cadherin-mediated cell-cell adhesio

70 cell-aggregation assays demonstrated that O-mannosyl glycans are crucial for cadherin-based cell adh

71 O-mannosyl glycans are known to play an important role in

72 ing mass spectrometry, we demonstrate that O-mannosyl glycans are present on E-cadherin, the major ce

73 Despite the critical role of O-mannosyl glycans for arenavirus binding under normal con

74 GnT-V is involved in synthesizing branched O-mannosyl glycans in brain, but the function of these bra

75 In mammals, biosynthesis of O-mannosyl glycans is initiated by a complex of mutually i

76 yltransferase LARGE, of the phosphorylated O-mannosyl glycans on alpha-dystroglycan that is required

77 feature of these disorders is the lack of O-mannosyl glycans on alpha-dystroglycan, resulting in abn

78 Thus, modifications by LARGE but not O-mannosyl glycans themselves are most likely the crucial

79 1), which is crucial for the elongation of O-mannosyl glycans, have mainly been associated with muscl

80 on by binding to the matriglycan moiety of O-mannosyl glycans, we hypothesized that EYS interacted wi

81 ylglucosaminyltransferase 1) that modifies O-mannosyl glycans.

82 hosphate (M6P) is an essential precursor for mannosyl glycoconjugates, including lipid-linked oligosa

83 e results suggest that these microbial alpha-mannosyl glycolipids are capable of being recognized by

84 The potentially antigenic alpha-mannosyl glycolipids contributed to the protection of mi

85 Several microbial alpha-mannosyl glycolipids, in which the 2'-OH group is in the

86 the preparation of unusual phosphorylated O-mannosyl glycopeptides derived from alpha-DG by a strate

87 ed 27 genomic regions and 3 genes (alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransfe

88 of human Tregs, we determined that alpha-1,3-Mannosyl-Glycoprotein 2-beta-N-Acetylglucosaminyltransfe

89 ts up-regulate the transcription of beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransfe

90 -3), odds ratio = 4.8) maps to the alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransfe

91 The calculated free energy of activation for mannosyl glycosylation (23 kcal/mol) agrees very well wi

92 nd RP76 are mechanistically linked in that O-mannosyl glycosylation controls targeting of EYS protein

93 Mutations in genes involved in protein O-mannosyl glycosylation give rise to a group of neurodeve

94 interaction with the matriglycan and that O-mannosyl glycosylation is required for photoreceptor sur

95 glycosyltransferases that act early in the O-mannosyl glycosylation pathway.

96 sferase 1 (POMGnT1), an enzyme involved in O-mannosyl glycosylation, cause retinitis pigmentosa (RP),

97 ) caused by mutations in genes involved in O-mannosyl glycosylation.

98 muscular dystrophies caused by defects in O-mannosyl glycosylation.

99 n at C1, as was shown by modeling an alpha-d-mannosyl group into the sugar binding site.

100 a 99mTc-labeled agent having 18 DTPA and 82 mannosyl groups attached to a polylysine of 100 units ([

101 lent to multivalent as the density of mobile mannosyl groups increases; such avidity switching enhanc

102 alization of N-glyans containing nonreducing mannosyl groups, accentuating the GNA vesicular staining

103 by nanopartices presenting a high density of mannosyl groups.

104 GDP-mannose mannosyl hydrolase (GDPMH) from Escherichia coli is a 36

105 GDP-mannose mannosyl hydrolase (GDPMH) is an unusual Nudix family me

106 Escherichia coli GDP-mannose mannosyl hydrolase (GDPMH), a homodimer, catalyzes the h

107 The Nudix hydrolase GDP-mannose mannosyl hydrolase (Gmm) contributes to this diversity b

108 12 in subsite -5 concluded to be involved in mannosyl interaction.

109 annostatin A best mimics the covalent linked mannosyl intermediate, which adopts a 1S5 skew boat conf

110 Glycosylation of a C-2-O-acetyl mannosyl iodide donor in the presence of silver triflate

111 gest that it does not mirror the behavior of mannosyl iodides lacking bridging acetal protecting grou

112 cosidation of trimethylene oxide (TMO) using mannosyl iodides.

113 e modifies the mannose unit of the substrate mannosyl-Kdo2-1-dephospho-[4'-(32)P]lipid IV(A).

114 uble mutant completely or partially restored mannosyl levels.

115 ith a wide range of galactosyl, glucosyl and mannosyl linkages that do not directly reflect cereal ro

116 is highly expressed in brain and branches O-mannosyl-linked glycans.

117 O-Mannosyl-linked glycosylation is abundant within the cen

118 T-Vb activity promotes the addition of the O-mannosyl-linked HNK-1 modification found on the developm

119 The best ligand was mannosyl-lipoarabinomannan, followed by lipomannan, phos

120 ational analysis by NMR has shown that the O-mannosyl modification does not exert major conformationa

121 OMGnT1, which attaches beta(1,2)-GlcNAc to O-mannosyl moietes, whereas the unphosphorylated derivate

122 (111) surfaces onto which are grafted either mannosyl moieties or a mixture of mannose and spacer alc

123 ypical beta-amide bond is present in the Trp-mannosyl moiety.

124 However, the sec14-1(ts) strain had elevated mannosyl-monoinositolphosphoryl-ceramide levels, and the

125 a mannosyl monosaccharide moiety in 2 and to mannosyl monosaccharide and disaccharide moieties in 1,

126 e core of these antibiotics is attached to a mannosyl monosaccharide moiety in 2 and to mannosyl mono

127 was increased by co-expression of protein:O-mannosyl N-acetylglucosaminyltransferase 1.

128 Readily prepared mannosyl n-pentenylorthoesters (NPOEs) serve as donors i

129 ts and isolated a gene that coded a putative mannosyl-oligosaccharide glucosidase (OsMOGS), an orthol

130 Genetic defects in MOGS, the gene encoding mannosyl-oligosaccharide glucosidase (the first enzyme i

131 11 years, with MOGS-CDG and biallelic MOGS (mannosyl-oligosaccharide glucosidase) mutations (GenBank

132 ipoarabinomannan is mediated by the terminal mannosyl oligosaccharides of this lipoglycan.

133 is additionally modified by a galactosyl-, a mannosyl-, or a glutamyl-residue.

134 Possible conformations of the mannosyl oxacarbenium ion and an enzyme-linked intermedi

135 xide, the only species observed were the two mannosyl oxysulfonium ions, yet the reactions were still

136 ion was also observed under conditions where mannosyl-P-dolichol (Man-P-dol) stimulated the biosynthe

137 ch as lysophosphatidylcholine, sulfatide, or mannosyl-phosophomycoketide, but not lipopeptide ligands

138 Dolichyl mannosyl phosphate synthase is associated with membranes

139 bility of anthocyanins to negatively charged mannosyl-phosphate groups within the polysaccharide moie

140 beta-D-mannosyl phosphomycoketide (C32-MPM), a naturally occurr

141 ken as reference, mutants DeltaMnn4 (with no mannosyl-phosphorylation) and DeltaMnn2 (linear N-glycos

142 at 24 hr was 2.84 +/- 0.83% for [99mTc]DTPA-mannosyl-polylysine and 0.22 +/- 0.12% for [99mTc] DTPA-

143 ocalize to the Golgi and contribute to the O-mannosyl post-phosphorylation modification of alpha-DG.

144 annomutase involved in the biosynthesis of a mannosyl precursor needed for the biosynthesis of the co

145 dies reactive with both mimotopes and with a mannosyl preparation were observed to bind to envelope p

146 C-glycosylation to provide the alpha-allyl-C-mannosyl product 18 with excellent stereoselectivity.

147 The desired beta-allyl-C-mannosyl products 42 and 43 were obtained, albeit in low

148 bligatory step for the addition of the first mannosyl residue during the biosynthesis of GPIs, our re

149 hed that a glycopeptide having a 6-phospho-O-mannosyl residue is not an acceptor for action by the en

150 e, a third P-EthN group linked to the middle mannosyl residue was found.

151 xyl group at the C-2 position in the central mannosyl residue.

152 dues followed by two or three alpha-6-linked mannosyl residues branched with single alpha-mannopyrano

153 linear LM precursor with approximately 10-12 mannosyl residues followed by additional mannosylation o

154 o inositol has 5-7 unbranched alpha-6-linked-mannosyl residues followed by two or three alpha-6-linke

155 f glycoside hydrolase family 38, cleaves two mannosyl residues from GlcNAcMan(5)GlcNAc(2) as part of

156 ) catalyzes the sequential hydrolysis of two mannosyl residues from GlcNAcMan(5)GlcNAc(2) to produce

157 The level of mannosyl residues in stem glucomannans decreased by appr

158 solely mediate the priming, the presence of mannosyl residues in the cell wall of C. albicans is nev

159 he misincorporation of glucosyl residues for mannosyl residues into the glycoconjugates of worms and

160 er disease, for which an enzyme with exposed mannosyl residues targets mannose receptors (MR) on macr

161 ed of mannosyl and glucosyl residues and the mannosyl residues were acetylated at O-2 and O-3.

162 further strengthened by interactions of core mannosyl residues with a secondary conserved site on the

163 ster of nonreducing terminal alpha1,3-linked mannosyl residues, and the other type for complex N-link

164 After these branched mannosyl residues, the alpha-6-linked mannan chain is te

165 of C. albicans that are defective in or lack mannosyl residues, we show that alterations in the manno

166 inositol anchor containing five alpha-linked mannosyl residues.

167 ents, as does the conformation of the glycon mannosyl ring in the product of the glycosylation reacti

168 brain, but the function of these branched O-mannosyl structures is unresolved using mice that lack t

169 he intermediacy of 1,3-dioxanium ions in the mannosyl system and an answer to why these do not form f

170 (2-iodophenyl)ethylthiocarbonyl)benzylidene]-mannosyl thioglycosides are first used to introduce the

171 he rough endoplasmic reticulum and catalyzes mannosyl transfer from GDP-mannose to the hydrophobic lo

172 PMT4 encodes a protein mannosyl transferase (pmt) required for O-linked glycosy

173 Protein-O-mannosyl transferase 1 (POMT1) is the first enzyme requi

174 Constructs expressing lpcC display only mannosyl transferase activity.

175 The Candida albicans MNT1/KRE2 mannosyl transferase family is represented by five membe

176 inactivating the respective putative protein mannosyl transferase genes Msmeg_5447 and Rv1002c.

177 The mannosyl transferase is associated with the inner membra

178 racterization of the Rhizobium leguminosarum mannosyl transferase LpcC, which adds a mannose unit to

179 LpcC encodes a highly selective mannosyl transferase that utilizes GDP-mannose to glycos

180 (GDP-D-mannose dehydratase) and rfbZ (first mannosyl transferase), all of which are active in the sy

181 is homologous to Caenorhabditis elegans beta-mannosyl transferase, and it lies between Nup98 and CARS

182 ose:polypeptide mannosyltransferase (protein mannosyl transferase; PMT), was developed.

183 Mutations in the gene coding for protein O-mannosyl-transferase 2 (POMT2) are known to cause severe

184 ctional homolog of the yeast Smp3 GPI fourth mannosyl-transferase.

185 e recognition model and confirm an inverting mannosyl-transferring reaction mechanism by the enzyme c

186 espectively, provide the corresponding alpha-mannosyl triflate as demonstrated by NMR spectroscopy.

187 ng to the formation of an intermediate alpha-mannosyl triflate.

188 d a lot of attention since the corresponding mannosyl triflates often give excellent selectivity.

189 Phosphorylated O-mannosyl trisaccharide [N-acetylgalactosamine-beta3-N-ac

190 saminyltransferase2 (B3GALNT2) to form the O-mannosyl trisaccharide.

191 lipoarabinomannan (LAM) that lacks terminal mannosyl units (AraLAM).

192 e a significant and regulatable precursor of mannosyl units in lipid-linked oligosaccharides and glyc

193 olated from Mtb and LAM lacking the terminal mannosyl units isolated from an avirulent mycobacterium

194 We have determined that the terminal mannosyl units of the M. tuberculosis surface lipoglycan

195 ant that targets Kupffer cells, in which the mannosyl units on albumin allows their specific uptake b