ライフサイエンスコーパス: maternal effect

1 growth through an adaptive hormone-mediated maternal effect.

2 nction in High LG offspring, eliminating the maternal effect.

3 ryo development phenotypes are a result of a maternal effect.

4 These genes may be related to maternal effect.

5 hood infection status, indicating a specific maternal effect.

6 e direct genetic effect of the queen without maternal effect.

7 ective embryogenesis of the mpk6 mutant is a maternal effect.

8 logical contexts that favor the evolution of maternal effects.

9 .5-21.5 years after gestation to investigate maternal effects.

10 methodological implications for the study of maternal effects.

11 development and for early embryogenesis via maternal effects.

12 DT, extends directly to the investigation of maternal effects.

13 valid tests for significant dominance and/or maternal effects.

14 parate estimation of X-linked, dominance and maternal effects.

15 environment, suggesting either dominance or maternal effects.

16 ernal grandparents yields an LRT specific to maternal effects.

17 ssociations were stronger in the presence of maternal effects.

18 ining information, in an independent LRT for maternal effects.

19 embryonic Tgfbkm2 genotype, also depends on maternal effects.

20 nt source of genetic variance contributed by maternal effects.

21 ential response to selection in the event of maternal effects.

22 l weight was heritable and itself subject to maternal effects.

23 e and maternal weight as specific sources of maternal effects.

24 les of phytohormone signalling in regulating maternal effects.

25 ng environments failed to evolve randomizing maternal effects.

26 three genotypes were present to control for maternal effects.

27 to contribute to adaptation than randomizing maternal effects.

28 hich most likely reflects the dissipation of maternal effects.

29 r male behavior during breeding by adjusting maternal effects according to prenatal conditions.

30 d models to fit the diagnostic data, genetic maternal effects accounted for 7.6% (95% credible interv

31 however, the genotype of the mother via its maternal effect accounts for a considerable portion of t

32 The hypothesis that maternal effects act as an adaptive bridge in translatin

33 e or actuarial senescence; this implies that maternal effect aging is a fundamentally distinct demogr

34 n throughout development, using a semiviable maternal-effect allele and wild-type or dominant-negativ

35 Z-linked maternal-effect alleles that help sons and harm daughter

36 own nearby susceptibility locus, or a direct maternal effect alone.

37 e at or near the RHD locus and from a direct maternal effect alone.

38 We show that this is a maternal effect and is not attributable to the defects i

39 JIL-1 has a strong maternal effect and JIL-1 activity is required at all st

40 ell formation and cytokinesis in a series of maternal effect and zygotic anillin alleles.

41 ied in nearly saturating genetic screens for maternal effect and zygotic lethals is particularly nota

42 ress in understanding the pattern formation, maternal effects and evolution of this essential unit of

43 Mutations with both sporophytic maternal effects and gametophytic maternal effects have

44 We further demonstrate how maternal effects and imprinting effects can be distingui

45 The presence of maternal effects and phenotypic plasticity could have mu

46 on screen in the zebrafish, we identified 47 maternal-effect and five paternal-effect mutants that ma

47 We describe the maternal-effect and zygotic phenotypes of null mutations

48 ost-associated fitness, ruled out nongenetic maternal effects, and discuss the maintenance of ecologi

49 ons hinges on the existence of deterministic maternal effects, and that such deterministic maternal e

50 highlights the importance of studying these maternal effects, and they enhance our concern over the

51 Although maternal effects are common, evidence for their adaptive

52 However, in most of these analyses maternal effects are confounded with genomic imprinting

53 ng-lived species, it has been suggested that maternal effects are masked by environmental variables a

54 t is reasonable to hypothesize that diabetic maternal effects are mediated by 1 or more pathways acti

55 aternal effects, and that such deterministic maternal effects are more likely to contribute to adapta

56 enetic effects in OCD are overestimated when maternal effects are not modeled.

57 Maternal effects are not necessarily static, however, si

58 that phenotypic plasticity and anticipatory maternal effects are sufficient to explain growth rate d

59 While maternal effects are well documented, the longevity and

60 g sex chromosomes, cytoplasmic elements, and maternal effects, are likely to play an important role i

61 Our results establish genetic maternal effects as influencing risk for OCD in offsprin

62 ssfully differentiate between imprinting and maternal effects as the cause of apparent parent-of-orig

63 not be explained by genetic modifiers or by maternal effects, as these divergent phenotypes were dis

64 calculations for child, parent-of-origin and maternal effects, as well as for gene-environment intera

65 s of offspring (child), parent-of-origin and maternal effects, based on genotype data from a variety

66 ic tra mRNA in eggs as predicted by this tra maternal effect, but not predicted by the prevailing vie

67 ion, tested the allergen independence of the maternal effect by using a second allergen, casein, for

68 erally, it provides important information on maternal effects by showing how environmental cues exper

69 Thus, strong maternal effects can account for frequently observed, bu

70 e generally, our study highlights that while maternal effects can be an important source of personali

71 enetic models show that senescence for these maternal effects can evolve in the absence of reproducti

72 er, brief periods of increasingly beneficial maternal effects can evolve when fertility increases wit

73 Yet-unidentified maternal effects can have a pronounced influence on plan

74 ght-related traits in mice to illustrate how maternal effects can mimic imprinting.

75 trait maternal effects shows that individual maternal effects cannot be studied in isolation, and tha

76 s, we simulate the evolution of multivariate maternal effects (captured by the matrix M) in a fluctua

77 leles are eliminated via a dominantly-acting maternal effect combined with slower-acting standard neg

78 t-offspring regressions provide evidence for maternal effects, comparable in magnitude to those repor

79 Maternal effects, crossgenerational influences of the mo

80 ic function, tbx5a, and one gene with strong maternal effect, ctnnb2.

81 The magnitude of these maternal effects decreased with age.

82 Fourth, hybrid sterility does not involve a maternal effect, despite earlier claims to the contrary.

83 Thus, the maternal-effect DNMT1o protein is uniquely poised during

84 tral patterning, indicating that the fusilli maternal effect does not depend on germ-line expression

85 Maternal-Effect Dominant Embryonic Arrest ("Medea") fact

86 seed traits are proposed, with inclusion of maternal effects, embryo or endosperm effects of QTL, en

87 In genetic screens for temperature-sensitive maternal effect embryonic lethal (Mel) mutants, we have

88 In addition to the maternal-effect embryonic lethal phenotype, aph-2 mutant

89 Interestingly, the maternal-effect embryonic lethality, larval lethality, a

90 These maternal effects, evidently stimulated by high-quality t

91 selection on other traits, large cross-trait maternal effects evolve from those maternal traits that

92 However, whether such maternal effects exist for adult sons is largely unknown

93 -genetic findings are compatible with strong maternal effects; G x E correlations likely underestimat

94 ed by a transcriptional network comprised of maternal effect, gap, pair-rule, and segment polarity ge

95 Thus, Npm2 is a maternal effect gene critical for nuclear and nucleolar

96 that the oocyte- and early embryo-restricted maternal effect gene Mater (Nlrp5) localizes to, and is

97 Differentiation of the EVL requires the maternal effect gene poky/ikk1 in EVL cells prior to est

98 We find dHIP14 to be an essential maternal effect gene required for photoreceptor synaptic

99 eport epigenetic repressor Smchd1 as a novel maternal effect gene that regulates the imprinted expres

100 led that SMCHD1 plays an important role as a maternal effect gene that regulates the master switch of

101 hese findings indicate that Setd1b serves as maternal effect gene through regulation of the oocyte ge

102 xperiments indicate that CTCF is a mammalian maternal effect gene, and that persistent transcriptiona

103 DPPA3/Stella/PGC7, encoded by a maternal effect gene, is present in the nucleus and cyto

104 When aposematism is controlled by a maternal effect gene, the difficulty of initial rarity m

105 n ovulated eggs, indicating that MOEP19 is a maternal effect gene.

106 also known as NLRP5), which is encoded by a maternal effect gene.

107 may function as a previously uncharacterized maternal effect gene.

108 It qualifies as a maternal-effect gene because the source of pre-implantat

109 We find that mutations in the maternal-effect gene emb-4 cause defects in both PIE-1 d

110 nd molecular identification of the zebrafish maternal-effect gene mission impossible (mis).

111 Zar1 is the first identified oocyte-specific maternal-effect gene that functions at the oocyte-to-emb

112 ly established by bicoid, a rapidly evolving maternal-effect gene, working with hunchback, which is e

113 SCMC) that contains four proteins encoded by maternal effect genes (Mater, Filia, Floped and Tle6).

114 Our work strongly suggests that maternal effect genes and developmental heterochronies t

115 uccino genetic loci were first identified as maternal effect genes in Drosophila.

116 Maternal effect genes play critical roles in early embry

117 ation exemplifies a large class of so-called maternal effect genes that regulate key events during ea

118 stella is thus one of few known mammalian maternal effect genes, as the phenotypic effect on embry

119 basonuclin is a new member of the mammalian maternal-effect genes and, interestingly, differs from t

120 ffers from the previously reported mammalian maternal-effect genes in that it also apparently perturb

121 Selection on maternal-effect genes may substantially alter the evolut

122 the general understanding of the dynamics of maternal-effect genes, including how selection acts on t

123 Encoded by maternal-effect genes, these factors accumulate during o

124 Here we define meg-1 and meg-2 (maternal-effect germ-cell defective), which are expresse

125 The MEG (maternal-effect germline defective) proteins are germ pl

126 P granule segregation depends on MEG (maternal-effect germline defective)-3 and MEG-4, which a

127 The characterization of many gametophytic maternal effect (GME) mutants affecting seed development

128 lighted between the two populations once the maternal effects had been diminished after several gener

129 ely cued for their light environment through maternal effects have 3.4 times greater fitness than oth

130 porophytic maternal effects and gametophytic maternal effects have been identified.

131 asures of maternal condition to determine if maternal effects have long-lasting influences on male of

132 These maternal effect hypomorphic phenotypes are associated wi

133 predicts that the evolution of deterministic maternal effects (i.e., anticipatory maternal effects or

134 In contrast, randomizing maternal effects (i.e., diversifying and conservative be

135 We assessed evidence of a maternal effect in a cohort of families containing >=3 p

136 rete-trait analysis, we found evidence for a maternal effect in chromosome region 10p12 across the th

137 hanism was supported by the observation of a maternal effect in reciprocal crosses between the wild t

138 ll but one of the mutations recovered show a maternal effect in their interaction with ftz.

139 ex imbalances can create the appearance of a maternal effect in upward-looking analyses and may have

140 In addition, evidence of maternal effects in both traits adds to a growing body o

141 ur approach can easily be adapted to examine maternal effects in different systems, and because it do

142 rcomes this challenge to separate direct and maternal effects in intact families through an analysis

143 s, we find a striking pattern of cross-trait maternal effects in which maternal characters influence

144 l for more studies that measure multivariate maternal effects in wild populations.

145 al sciences, the principle of minimal shared maternal effects, in light of the growing awareness that

146 re associated with larger birth size through maternal effects; in the fetus, the height- and metaboli

147 Maternal effects influence chick coloration, but coot fe

148 Extension to incorporate maternal effect is also given.

149 We provide evidence that this maternal effect is due to the necessity of a maternal st

150 a single character, whereas the evolution of maternal effects is poorly understood in the presence of

151 eonatal survival, we find that selection for maternal effects is the product of age-specific fertilit

152 H-1 function causes sterility that is mainly maternal effect, is manifested predominantly at elevated

153 le-queen colonies in Alpine silver ants is a maternal effect killer.

154 MAB1 resembles the animal key ACD regulator Maternal Effect Lethal 26 (MEL-26).

155 embryos whose mothers are homozygous for the maternal effect lethal mutation gnu (GNU embryos) under

156 identified in Drosophila through screens of maternal effect lethal mutations for defects in spindle

157 e adaptors is the BTB-domain protein MEL-26 (maternal effect lethal).

158 ns in the biotin-binding region of bpl-1 are maternal-effect lethal and cause defects in embryonic po

159 Although maternal-effect lethal and female-sterile screens have i

160 A maternal-effect lethal screen identified mutants in the

161 hold-dependent gene drive system, designated maternal-effect lethal underdominance (UD(MEL)), in whic

162 We previously identified a Drosophila maternal effect-lethal mutant named 'no poles' (nopo).

163 cycle regulators, we identified a Drosophila maternal effect-lethal mutant that we named ;no poles' (

164 A new maternal effect mutation in maize, maternal effect lethal1 (mel1), causes the production of

165 This maternal effect lethality in Drosophila is similar to th

166 BMP pathway components, and (2) significant maternal effect lethality that can be rescued by an incr

167 Similar pharyngeal defects and maternal effect lethality were found in sqv-1, sqv-8, ri

168 ty, growth retardation, brain disorders, and maternal effect lethality, phenotypes commonly observed

169 -9 mutations also had a recessive phenotype, maternal effect lethality, which implicated E(var)3-9 fu

170 The dcap-g and incenp mutations cause maternal effect lethality, with embryos from mutant moth

171 tion, cytoskeletal organization defects, and maternal effect lethality.

172 or Larp (La-related protein) which displayed maternal-effect lethality and male sterility.

173 n ML-IV gene is capable of rescuing both the maternal-effect lethality and the lysosome-accumulation

174 inked with a zygotic antidote able to rescue maternal-effect lethality of the other toxin.

175 Strong sqv mutations result in maternal-effect lethality, caused in part by the failure

176 Our null mutations in cup-5 cause maternal-effect lethality.

177 This genome scan revealed five separate maternal-effect loci that caused a diversity of patterns

178 However, maternal effects may also play a role.

179 lyze the relative contribution of direct and maternal effect (ME) QTL to early growth in mice using a

180 Maternal effects mediated by prenatal hormone exposure a

181 wth, but recent studies have also emphasized maternal effects mediated by size or age.

182 We speculate that similar maternal effects might explain the missing heritability

183 Extension of our maternal effects model to other ecological and social co

184 We have used the maternal effect mutant ichabod, which is deficient in ma

185 stunter1 (stt1) is a novel, recessive, maternal effect mutant in maize that displays viable, mi

186 A novel gametophytic maternal-effect mutant defective in early embryo and end

187 dentify key genes involved, we embarked on a maternal-effect mutant screen in the zebrafish.

188 Here we report on a zebrafish maternal-effect mutant, brom bones, which is defective i

189 and phosphorylation are disrupted in another maternal-effect mutant, nuclear-fallout.

190 Maternal-zygotic and maternal-effect mutants demonstrate a crucial requiremen

191 This collection of maternal-effect mutants provides the basis for a molecul

192 We identified 68 maternal-effect mutants.

193 A new maternal effect mutation in maize, maternal effect letha

194 A zebrafish maternal effect mutation, in the gene hecate, results in

195 This recessive maternal-effect mutation disrupts the specification of i

196 ta-catenin in dorsal axis formation, but the maternal-effect mutation ichabod disrupts beta-catenin a

197 A female-sterile zebrafish maternal-effect mutation in cellular atoll (cea) results

198 ryos from females homozygous for a recessive maternal-effect mutation in the gene aura exhibit defect

199 To test this hypothesis, we generated a maternal-effect mutation of Brg1, which encodes a cataly

200 s to complement the originally isolated aura maternal-effect mutation, confirming gene assignment.

201 roteins are conserved in humans, and similar maternal effect mutations may result in recurrent embryo

202 wispy (wisp) maternal-effect mutations in Drosophila block developmen

203 Maternal-effect mutations in zebrafish ybx1 lead to dere

204 Maternal-effect mutations of other human NLRP genes, NLR

205 Thus, the chromosomes act as maternal effect neo-W's, or W-prime (W') chromosomes, wh

206 g the Drosophila eRF1 and eRF3 show a strong maternal-effect nonsense suppression due to readthrough

207 was no evidence for repression by a strictly maternal effect; nor was there any evidence for enhancem

208 of evidence, in familial epilepsies, of the maternal effect observed in population-based studies.

209 GP), a generalisation of more widely studied maternal effects, occurs whenever environmental cues exp

210 The maternal effect of AP2 on seed mass involves the regulat

211 enetic effect of worker bees and the genetic maternal effect of the queen, whereas model 2 considered

212 different early life impacts, including (i) maternal effects of length on egg weight, potentially af

213 efore, our results suggest that rank-related maternal effects of prenatal androgen exposure can adapt

214 n population growth and fitness of pike than maternal effects of size on offspring survival.

215 eft study, to now investigate both fetal and maternal effects of the IRF6 gene.

216 ue provides a powerful tool for studying the maternal effects of zygotic lethal mutations.

217 erm-line clones of fusilli mutations have no maternal effect on dorsal-ventral patterning, indicating

218 t mothers gives dose-dependent rescue of the maternal effect on embryo hatch rate.

219 The mutation had a profound maternal effect on embryonic viability, revealing an acu

220 We found no evidence of a maternal effect on epilepsy risk in this familial epilep

221 dependent memory, suggesting a 'detrimental' maternal effect on neural development.

222 The maternal effect on seed lipid content is attributable to

223 The maternal effects on both long-term depression and PPD we

224 Experimental evidence for maternal effects on caste determination, the differentia

225 This finding suggests that maternal effects on early life survival such as maternal

226 In birds, maternal effects on egg-laying order and offspring growt

227 ale behavior that are critical for mediating maternal effects on offspring development, such as postp

228 Non-genetic maternal effects on sex determination were negligible in

229 stern breed was used to identify genetic and maternal effects on the acquisition and development gut

230 y is produced by persistent and sex-specific maternal effects on the growth and morphology of offspri

231 juvenile hormone, and vitellogenin regulates maternal effects on the production of alternative phenot

232 so resulted in aberrant egg morphology and a maternal-effect on embryonic chromosome segregation and

233 s of variation, including direct genetic and maternal effects, on risk for OCD.

234 se embryo suggests that Pms2 deficiency is a maternal effect, one of a limited number identified in t

235 This is a direct maternal effect, operating independently from transgener

236 Consequently, there is no maternal effect or developmental event that sets the pha

237 ly expressed genes could not be explained by maternal effects or by chance differences in the backgro

238 ypes in mutant embryos was not likely due to maternal effects or failure to eliminate gene function.

239 inistic maternal effects (i.e., anticipatory maternal effects or transgenerational phenotypic plastic

240 ociated with birth weight with a significant maternal effect (p = 1.6 x 10-4).

241 th weight in a similar way but with a weaker maternal effect (p = 6.4 x 10-3) and a stronger fetal ef

242 stational duration and preterm birth through maternal effects (p = 3.3 x 10-2 and p = 4.5 x 10-3, res

243 e of PE is reported, with debilitating foeto-maternal effects, particularly among primigravid women.

244 ss-of-function genotype is associated with a maternal-effect phenotype that results in drastically re

245 n is the most likely reason for its use as a maternal-effect protein; stable ooplasmic stores of Dnmt

246 These marks are under the control of maternal effect proteins supplied in the oocyte.

247 P cluster that showed strong association and maternal effects, providing a potential substrate for ep

248 atidiform mole (FBHM) is the only known pure maternal-effect recessive inherited disorder in humans.

249 The mechanisms of this maternal effect remain poorly understood.

250 els of nonpaternity (up to 15%), the greater maternal effect remained.

251 cess of germ-cell formation in Drosophila, a maternal-effect screen using the FLP/FRT-ovoD method was

252 Here, we report the creation of maternal-effect selfish genetic elements in Drosophila t

253 able to evaluate the fitness consequences of maternal effect senescence across species with diverse a

254 We demonstrate that fertility and maternal effect senescence are likely to experience diff

255 Current evolutionary theory considers such maternal effect senescence as part of a unified process

256 al age for late maternal ages, implying that maternal effect senescence can evolve through the same p

257 enotypic studies, questions remain about how maternal effect senescence impacts evolutionary fitness.

258 To understand the influence of maternal effect senescence on population dynamics, fitne

259 and without maternal effects, we found that maternal effect senescence significantly reduces fitness

260 Maternal effect senescence-a decline in offspring surviv

261 The presence of these cross-trait maternal effects shows that individual maternal effects

262 lysis, we found the strongest evidence for a maternal effect (single-point LOD of 2.85; multipoint LO

263 vpr-1 null mutants are maternal effect sterile due to arrested gonadogenesis fo

264 The Maternal-Effect Sterile (MES) proteins are essential for

265 The maternal-effect sterile (MES) proteins are maternally su

266 Four maternal-effect sterile genes, mes-2, mes-3, mes-4, and

267 The Caenorhabditis elegans maternal-effect sterile genes, mes-2, mes-3, mes-4, and

268 methylation of the molecular basis for such maternal effects suggested differences in the epigenetic

269 n addition, the suppressor itself exhibits a maternal effect, suggesting that it may act on chromatin

270 anisms underlying the weak influence of this maternal effect, suggesting that these may be general fo

271 frequency, while survival due to second-site maternal-effect suppressors occur at a ~10(-5) frequency

272 signaling, we conducted a genetic screen for maternal-effect suppressors of dpp haplo-insufficiency.

273 ancement has two components: (1). a strictly maternal effect that is transmitted to the females indep

274 ose that mosaicism for paternal alleles is a maternal effect that results from Pms2 deficiency during

275 Most predictions focus, however, on maternal effects that affect only a single character, wh

276 h an ability to manipulate male behavior via maternal effects that alter offspring phenotypes.

277 However, maternal effects that limit the caste of eggs may be mor

278 ailable on larval diapause or the intriguing maternal effects that regulate egg diapause.

279 mptions, such as the absence of dominance or maternal effects, that greatly weaken their discriminato

280 he phenomenon, with particular reference to 'maternal effects', the processes observed in many specie

281 he phenotype and genotype of a locus showing maternal effects, the conclusions are likely to be relev

282 elegans The element is made up of sup-35, a maternal-effect toxin that kills developing embryos, and

283 des the C. elegans ortholog of Hth, and that maternal-effect unc-62 mutations can cause severe poster

284 Maternal effects via hormonal transfer from the mother t

285 A maternal effect was detected for 8 sites.

286 than in offspring of male probands, and this maternal effect was restricted to offspring of probands

287 We tested whether this "maternal effect" was present in familial epilepsies, whi

288 By comparing models with and without maternal effects, we found that maternal effect senescen

289 for zygotic lethal mutations associated with maternal effects, we have identified rasp, a novel Droso

290 dels that differed in the way the direct and maternal effects were considered.

291 No significant maternal effects were found.

292 in most of the models, whereas epistatic and maternal effects were less common.

293 All mutants showed a maternal effect, whereby seeds inheriting a maternal mut

294 One such cause of phenotypic variation is a maternal effect, which is the influence of the environme

295 Maternal effects, which can have significant influence o

296 netics approach, we test the prediction that maternal effects will influence age-specific risk-taking

297 diverged populations that take into account maternal effects will shed further light on the true inc

298 Maternal effects, with association confined to maternall

299 We identified split top, a recessive maternal-effect zebrafish mutant that disrupts embryonic

300 We identified brambleberry, a maternal-effect zebrafish mutant that disrupts karyomere