ライフサイエンスコーパス: maternal obesity

1 rategy to prevent fetal overgrowth caused by maternal obesity.

2 rweight, and 1.26 (95% CI, 1.05 to 1.52) for maternal obesity.

3 es in a model of high fat diet (HFD)-induced maternal obesity.

4 ogated with diet reversal despite persistent maternal obesity.

5 hat are associated with high birthweight and maternal obesity.

6 as in preeclampsia, placental infection, or maternal obesity.

7 D, allergy, or autism spectrum disorder; and maternal obesity.

8 f lipolytic genes in mouse hearts exposed to maternal obesity.

9 D development in the offspring programmed by maternal obesity.

10 e phenotype observed in offspring exposed to maternal obesity.

11 silience to emotional dysfunction induced by maternal obesity.

12 oncentrations in pregnancy may be altered by maternal obesity.

13 was no difference in insulin action based on maternal obesity.

14 in the developing embryo brain cortex due to maternal obesity.

15 environment of pregnancies with and without maternal obesity.

16 overweight (OR 1.80, 95% CI 1.25, 2.59) with maternal obesity.

17 Ts) isolated from pregnancies complicated by maternal obesity.

18 n kinase, which was inhibited as a result of maternal obesity.

19 tabolic dysfunction linked to programming by maternal obesity.

20 Human milk composition is altered by maternal obesity.

21 o decrease the health burden associated with maternal obesity.

22 e was seen in DNV count per patient based on maternal obesity (72.0 versus 72.2 for maternal body mas

23 Maternal obesity, a major diabetes risk factor, reduces

24 Standard definitions of maternal obesity (according to prepregnancy body mass in

25 and function can be modified as a result of maternal obesity affecting materno-fetal fatty acids (FA

26 results support our hypothesis and show that maternal obesity affects offspring cardiac metabolism in

27 From these analyses we observed: (1) maternal obesity affects the maternal and fetal serum li

28 Maternal obesity affects these metabolic adjustments as

29 Maternal obesity also alters cardiac metabolism of carbo

30 dies of both rodents and non-human primates, maternal obesity also predicts a preference for palatabl

31 We hypothesized that maternal obesity alters fetal cardiac expression of meta

32 Collectively, these data indicate that maternal obesity alters metabolic, signaling, and epigen

33 consistent regarding the association between maternal obesity and Apgar score or cord pH in humans.

34 We investigated the association between maternal obesity and BPD using newborn screen metabolite

35 on, and other factors that often covary with maternal obesity and breast-feeding did not change these

36 The negative relationship between maternal obesity and breastfeeding is likely caused by a

37 id not fully explain the association between maternal obesity and breastfeeding outcomes.

38 size did not mediate the association between maternal obesity and childhood cancer.

39 r studies have reported associations between maternal obesity and childhood wheeze, asthma as well as

40 prolactin and prolactin receptor mutations, maternal obesity and diabetes mellitus, interventions du

41 gnancy and are independently associated with maternal obesity and dyslipidaemia.

42 is study aimed to elucidate the influence of maternal obesity and early life exposure to high-fat die

43 Maternal obesity and excessive gestational weight gain m

44 Rates of maternal obesity and gestational diabetes (GDM) are incr

45 Maternal obesity and gestational diabetes mellitus (GDM)

46 Evidence points to prenatal exposures to maternal obesity and gestational diabetes mellitus (GDM)

47 Maternal obesity and gestational diabetes mellitus (GDM)

48 Maternal obesity and gestational diabetes mellitus have

49 Maternal obesity and high-fat diet (HFD) predisposes off

50 Maternal obesity and higher early-mid gestational weight

51 We aimed to analyze relationships between maternal obesity and human milk metabolites, infant body

52 Maternal obesity and hyperglycemia increase risk of obes

53 These findings suggest that exposure to maternal obesity and hyperglycemia places girls at highe

54 ng evidence of a causal relationship between maternal obesity and impaired fetal and infant survival,

55 The association between maternal obesity and increased risks of stillbirth and i

56 Emerging concepts implicating maternal obesity and nutrition in the development of a r

57 and animals indicates an association between maternal obesity and offspring behavioral outcomes.

58 nt mechanisms explain why the combination of maternal obesity and offspring obesity leads to the most

59 Maternal obesity and offspring obesity led to reduced ex

60 The effects of maternal obesity and offspring obesity were, generally,

61 Maternal obesity and over-nutrition give rise to both ob

62 ive of this study was to evaluate effects of maternal obesity and over-nutrition on signalling of the

63 is no difference in the association between maternal obesity and periodontitis between females with

64 to evaluate the evidence for a link between maternal obesity and poor lactation performance.

65 ectin is a critical mechanistic link between maternal obesity and the development of metabolic diseas

66 men, there is a negative association between maternal obesity and the initiation as well as the conti

67 Maternal obesity and weight gain during pregnancy are ri

68 Both maternal obesity and, to a lesser extent, GDM were accom

69 l to understand the developmental effects of maternal obesity and/or type 2 diabetes mellitus and fur

70 of the most sensitive targets in response to maternal obesity and/or type 2 diabetes mellitus.

71 valence attributable to maternal overweight, maternal obesity, and excessive gestational weight gain

72 s among prenatal maternal cortisol profiles, maternal obesity, and repeated wheeze up to age 2 years

73 a significant role of early-life exposure to maternal obesity- and fetal growth-related factors in ch

74 3.27], and OR 4.47 [95% CI: 3.99, 5.23] for maternal obesity; and OR 1.39 [95% CI: 1.30, 1.49], OR 1

75 ed fertility, and pregnancies complicated by maternal obesity are associated with adverse outcomes, i

76 abolic disease in adult offspring exposed to maternal obesity are not known.

77 logical changes of pregnancy associated with maternal obesity are present from early pregnancy onward

78 omplications, increasing evidence implicates maternal obesity as a major determinant of offspring hea

79 Maternal obesity at conception alters gestational metabo

80 structure and efficiency are not affected by maternal obesity at E13.5, suggesting that the reduction

81 resent from early pregnancy onward, reducing maternal obesity before conception is probably the best

82 In countries with high prevalence of maternal obesity, birth spacing may merit exploration as

83 Maternal obesity can exacerbate this "resistance," sugge

84 llustrating that high fat diet (HFD)-induced maternal obesity can regulate fetal bone development.

85 These findings show that maternal obesity caused sex-specific cardiovascular aber

86 We demonstrate that maternal obesity causes early metabolic disorder in the

87 propose that low circulating adiponectin in maternal obesity causes fetal overgrowth and programs th

88 apanese macaque model to investigate whether maternal obesity combined with a Western-style diet (WSD

89 es include a role for in utero influences of maternal obesity compounded by the availability of energ

90 nor sleeping energy expenditure at 3 mo nor maternal obesity contributed to measures of body size at

91 Pregnancy complicated by maternal obesity contributes to an increased cardiovascu

92 Maternal obesity contributes to an increased risk of lif

93 Maternal obesity could also lead to poorer cognitive per

94 Because the long-term effects of maternal obesity could have profound public health impli

95 Maternal obesity demonstrates long-term effects on the a

96 Maternal obesity did not affect cardiac palmitoyl carnit

97 Moreover, maternal obesity disrupted the development of melanocort

98 Maternal obesity disturbs brain-gut-microbiota interacti

99 Exposure to maternal obesity during early development programmes adv

100 Exposure to maternal obesity during early-life can have adverse cons

101 Maternal obesity during gestation and lactation in obesi

102 Epidemiological studies show that maternal obesity during intrauterine and early postnatal

103 This research highlights that exposure to maternal obesity during lactation alone can programme ad

104 In conclusion exposure to maternal obesity during lactation programmes offspring a

105 Exposure to maternal obesity during lactation was a driver for reduc

106 is to investigate the programming effects of maternal obesity during preconception and the preconcept

107 Maternal obesity during pregnancy has been associated wi

108 Maternal obesity during pregnancy has immediate and long

109 Maternal obesity during pregnancy increases the risk for

110 Maternal obesity during pregnancy is associated with neu

111 In contrast, maternal obesity during pregnancy up-regulated the insul

112 Maternal obesity during pregnancy was associated with in

113 now the norm and are increasing the rates of maternal obesity during pregnancy.

114 utilized integrative multi-omics to examine maternal obesity effects on offspring neurodevelopment i

115 ate immune system in liver injury induced by maternal obesity followed by a postnatal obesogenic diet

116 However, little is known about the effect of maternal obesity, GDM and their interaction, on placenta

117 nal age, maternal hypertension of pregnancy, maternal obesity, gestational diabetes and pregnancy at

118 Maternal obesity has been associated with increased risk

119 Maternal obesity has been positively associated with ris

120 The prevalence of maternal obesity has increased dramatically with adverse

121 nt and nonhuman primate models investigating maternal obesity have highlighted the importance of the

122 Maternal obesity impairs fetal cardiomyocyte contractile

123 These results suggest that maternal obesity impairs fetal skeletal development thro

124 Maternal obesity impairs neurogenesis by reducing cell p

125 Maternal obesity impairs offspring brown adipocyte funct

126 In this study, we showed that maternal obesity in mice induces hypertrophy of the feta

127 nant maternal HF feeding resembles pregravid maternal obesity in mice, which reduces fetal and neonat

128 Maternal obesity in pregnancy increases the risk of adve

129 Maternal obesity in pregnancy is strongly associated wit

130 Maternal obesity in pregnancy predicts offspring psychop

131 Maternal obesity in pregnancy predisposes offspring to i

132 ion and fetal overgrowth in a mouse model of maternal obesity in pregnancy.

133 INTERPRETATION: Maternal obesity in sub-Saharan Africa is associated wit

134 Maternal obesity in the context of a postnatal hypercalo

135 In 6-month-old offspring, exposure to maternal obesity increased cardiac palmitoyl carnitine-s

136 ed obese mouse models, our study showed that maternal obesity increased fetal fat tissue mass, with a

137 Maternal obesity increased heart weight and peroxisome p

138 ition hypothesis, intrauterine influences of maternal obesity increased lifelong obesity risk in the

139 Maternal obesity increases offspring birth weight and su

140 this study were to test the hypothesis that maternal obesity increases oxidative stress during fetal

141 Maternal obesity increases risk for bronchopulmonary dys

142 Maternal obesity increases risk of infant mortality.

143 Maternal obesity increases the risk for pediatric obesit

144 Evidence suggests that maternal obesity increases the risk of fetal death, stil

145 The mechanisms by which maternal obesity increases the susceptibility to steatot

146 Herein, we have used a rat model of maternal obesity induced by a high-fat diet before and d

147 ss the relative contributions of exposure to maternal obesity, induced by a highly varied cafeteria d

148 at deposition and plays an important role in maternal obesity-induced high birth weight.

149 ectin gene knockout (Adipoq(-/-)) attenuated maternal obesity-induced high fetal fat tissue mass.

150 We conclude that maternal obesity-induced iron deficiency and fetal hypox

151 Maternal obesity induces DNA demethylation in the promot

152 othesis that neonatal hyperleptinemia due to maternal obesity induces persistent changes in the centr

153 ampal co-methylation network correlated with maternal obesity, infant behavior, infant hippocampal li

154 The mechanism by which maternal obesity influences fetal brain development and

155 Maternal obesity, insulin treatment, and suboptimal in-h

156 Maternal obesity interferes with the initiation and main

157 Maternal obesity is a global problem that increases the

158 Maternal obesity is a risk factor for childhood obesity;

159 We investigated whether maternal obesity is a risk factor for neonatal death in

160 Maternal obesity is a strong risk factor for preeclampsi

161 Maternal obesity is a worldwide problem associated with

162 Pre-pregnancy maternal obesity is associated with adverse offspring ou

163 Prepregnancy maternal obesity is associated with adverse outcomes for

164 Maternal obesity is associated with changes in the human

165 Maternal obesity is associated with increased birthweigh

166 Maternal obesity is associated with increased risk of de

167 Maternal obesity is associated with increased risks of g

168 The prevalence of maternal obesity is increasing at an alarming rate, and

169 The prevalence of maternal obesity is increasing in the United States.

170 In high-income countries, maternal obesity is one of the most important modifiable

171 exposure to in-utero inflammation induced by maternal obesity is proposed as an underlying mechanism

172 intervention studies have been done in which maternal obesity is reversed and the consequences for of

173 Maternal obesity is thought to increase the offspring's

174 and fetal development, and we now know that maternal obesity leads to increased inflammation, oxidat

175 odel, which posits that prenatal exposure to maternal obesity leads to neurobehavioral flexibility de

176 The mechanism by which maternal obesity leads to these outcomes is not well und

177 Maternal obesity lengthens and amplifies the peak in alt

178 Our results indicate that, although maternal obesity may adversely affect the early infant i

179 Growing evidence suggests that maternal obesity may affect the intrauterine environment

180 Maternal obesity may also have a direct biological assoc

181 assessed whether peripheral inflammation in maternal obesity may be transferred to the offspring bra

182 enin signaling in MSCs of infants exposed to maternal obesity may have important consequences for MSC

183 Maternal obesity may lead to epigenetic alterations in t

184 Data supported that the maternal obesity metabolic phenotype has a greater clini

185 It is unknown whether different maternal obesity metabolic phenotypes underlie the heter

186 e region overlapping mir-663 correlated with maternal obesity, metabolic and immune markers, and infa

187 Maternal obesity (MO) during pregnancy is linked to incr

188 d of pregnant women in the USA are obese and maternal obesity (MO) negatively affects fetal developme

189 Human studies show that maternal obesity (MO) predisposes offspring to cardiovas

190 Maternal obesity (MO) predisposes offspring to obesity a

191 Maternal obesity (MO) predisposes offspring to obesity a

192 Maternal obesity (MO) programs offspring obesity and met

193 ACT: Human epidemiological studies show that maternal obesity (MO) shortens offspring life and health

194 to rise worldwide and parallels the rise in maternal obesity (MO) that predisposes offspring to card

195 , the authors examined the association among maternal obesity, obesity subtypes, and spontaneous and

196 icantly increased odds of child obesity with maternal obesity (odds ratio [OR] 3.64, 95% CI 2.68-4.95

197 g for obesity in adolescent females included maternal obesity (odds ratio [OR], 3.46; 95% confidence

198 2.2; 95% confidence interval, 1.09-4.09) and maternal obesity (odds ratio, 3.43; 95% confidence inter

199 hich was exacerbated by previous exposure to maternal obesity (OffOb-OD), as demonstrated by raised a

200 Thus, we investigated the effects of maternal obesity on both fetal skeletal development and

201 ummarize recent research on the influence of maternal obesity on breastmilk composition and discuss t

202 ed sheep model to investigate the effects of maternal obesity on cardiac functions.

203 the cellular and molecular repercussions of maternal obesity on embryonic cortical neurogenesis.

204 onal studies provide evidence for effects of maternal obesity on her offspring's risks of obesity, co

205 egies for preventing the negative effects of maternal obesity on offspring development and adult heal

206 t can mitigate the adverse health effects of maternal obesity on offspring development and disease ri

207 al animal models to understand the impact of maternal obesity on offspring health.

208 nue to counteract the deleterious effects of maternal obesity on offspring neurodevelopment.

209 perimental studies support causal effects of maternal obesity on offspring outcomes, which are mediat

210 this study was to investigate the effect of maternal obesity on offspring's glucose metabolism durin

211 plementation reversed the adverse effects of maternal obesity on placental function and fetal growth.

212 f research investigating the consequences of maternal obesity on pregnancy and offspring health.

213 This study sought to examine the effect of maternal obesity on pregnancy complications in women wit

214 miologic evidence regarding the influence of maternal obesity on the risk of oral clefts is inconsist

215 impaired telomere elongation, occurred with maternal obesity or advanced age.

216 Altogether, mWD, independent of maternal obesity or insulin resistance, results in susta

217 gramming of hypertension arising from either maternal obesity or neonatal hyperleptinemia.

218 in childhood but it remains unclear whether maternal obesity or underweight associate with adult off

219 Early exposure to maternal obesity or Western-style diet (WD) increases st

220 Maternal obesity/overweight during pregnancy has reached

221 for congenital heart defects with increasing maternal obesity (P < 0.0001).

222 ow that in utero exposure to a MHFD, but not maternal obesity per se, increases fetal H3K14ac with co

223 lycemia or dyslipidemia, particularly due to maternal obesity, poses a threat to the optimal developm

224 Maternal obesity predisposes to metabolic dysfunction in

225 Maternal obesity (pregravid body mass index (BMI; weight

226 Five risk factors were defined: maternal obesity [prepregnant body mass index (BMI; in k

227 Data regarding the impact of maternal obesity programing of offspring fuel usage in h

228 Maternal obesity programmed increased adiposity and live

229 In utero exposure to maternal obesity programs increased obesity risk.

230 study identifies a novel mechanism by which maternal obesity programs obesity in offspring via incre

231 tment for lean body mass, sex, birth weight, maternal obesity, race, and other sociodemographic varia

232 The escalating prevalence of maternal obesity raises concerns about its influence on

233 Maternal obesity reduced synaptophysin expression in the

234 Maternal obesity reduces adipogenic progenitor density i

235 Maternal obesity represents a risk factor that contribut

236 Diet-induced maternal obesity resulted in fetal, but not placental, h

237 Maternal obesity results in decreased syncytiotrophoblas

238 Maternal obesity results in neurodevelopmental disorders

239 d persistent ductus arteriosus increase with maternal obesity severity.

240 PRRs of aortic arch defects increased with maternal obesity severity.

241 CI, 1.35-6.42) and more than quadrupled with maternal obesity status (BMI >/=30.0 kg/m(2); AOR, 4.34;

242 fetal heart lipidomes are more sensitive to maternal obesity than males; (3) changes in lipid supply

243 Early-life exposure of the PVH to maternal obesity through postnatal elevation of leptin m

244 model of diet-induced (high sugar/high fat) maternal obesity to explore the impact of metformin on m

245 Here, we used a mouse model of maternal obesity to investigate the importance of early

246 skeletal development and mechanisms linking maternal obesity to osteoblast differentiation in offspr

247 The prevalence of maternal obesity was 14%.

248 hite individuals [60.6%]), the prevalence of maternal obesity was 30.5% (n = 106 031).

249 Maternal obesity was a significant risk factor for neona

250 Maternal obesity was associated with an increased odds o

251 We conclude that in this model, maternal obesity was associated with changes in the infa

252 Maternal obesity was established by feeding C57BL/6 mice

253 Maternal obesity was established by prepregnant HF (ppHF

254 The risk associated with maternal obesity was greater for spina bifida and for ot

255 Maternal obesity was independently associated with highe

256 In non-Hispanic white women, maternal obesity was inversely associated with preterm b

257 In non-Hispanic black women, maternal obesity was inversely associated with preterm b

258 In Hispanic women, maternal obesity was not associated with preterm birth a

259 his association was stronger with increasing maternal obesity, was modified by gestational weight gai

260 Utilizing a non-human primate model of maternal obesity, we hypothesized that maternal consumpt

261 Using a mouse model of maternal obesity, we observed increased intake of a high

262 Metabolites altered by maternal obesity were used in linear mixed effect models

263 reduced H3K27me3 at genes upregulated due to maternal obesity, which could have resulted from reduced

264 Moreover, the association of maternal obesity with nonallergic asthma was observed in