ライフサイエンスコーパス: matrix metalloprotease

1 stent with the properties of a membrane type matrix metalloprotease.

2 analysis suggests that the enzyme was a non-matrix metalloprotease.

3 grading the matrix through the activation of matrix metalloproteases.

4 ttractants, leukocyte adhesion proteins, and matrix metalloproteases.

5 wo compounds known as specific inhibitors of matrix metalloproteases.

6 ored precursor by incompletely characterized matrix metalloproteases.

7 n of p87 and was suppressed by inhibitors of matrix metalloproteases.

8 cluding decorin, collagens, fibronectin, and matrix metalloproteases.

9 d to inflammatory response and inhibition of matrix metalloproteases.

10 cleavage takes place on the cell surface by matrix metalloproteases.

11 epend on actin cytoskeletal dynamics but not matrix metalloproteases.

12 lation of miR-34a also altered expression of matrix metalloproteases 1 and 2, the mediators involved

13 potential and led to increased expression of matrix metalloproteases 1 and 9 (MMP1 and MMP9).

14 roles of the upstream proteases thrombin and matrix metalloprotease-1 (MMP-1) in triggering PAR1-medi

15 In the present study, we found that matrix metalloprotease-1 (MMP-1) robustly activates the

16 It was recently shown that matrix metalloprotease-1 (MMP1) activation of the G prot

17 We used matrix metalloprotease-1 (MMP1) as a model system to stu

18 Matrix metalloprotease-1 (MMP1) is an important mediator

19 tween the catalytic and hemopexin domains of matrix metalloprotease-1 (MMP1) on type 1 collagen fibri

20 Matrix metalloprotease-1 (MMP1), a collagenase and activ

21 ased levels of mRNA for two PAR1 activators, matrix metalloprotease-1 and Factor Xa, suggesting a mec

22 r necrosis factor-alpha-induced collagenase (matrix metalloprotease-1) gene expression in dermal fibr

23 in the expression of alpha1 type I collagen, matrix metalloprotease-1, and platelet-derived growth fa

24 fficiently secreted (>80%); are cleaved with matrix metalloprotease-1; inhibit NF-kappaB driven trans

25 ividuals with detectable tissue inhibitor of matrix-metalloprotease-1 (TIMP-1) had a 3.5-fold greater

26 Matrix metalloprotease 11 (MMP-11), a protease associate

27 Matrix metalloprotease 12 plays a significant role in ai

28 RXP470.1 phosphinic peptide inhibitor toward matrix metalloprotease-12 (MMP-12) remain elusive.

29 obstruction of airways and higher levels of matrix metalloprotease-12 in sputa, suggesting that Pneu

30 oteinases, including neutrophil elastase and matrix metalloprotease-12, respectively.

31 igands CXCL5, CXCL1 and CCL3, cathepsins and matrix metalloprotease-12.

32 Further, MAC colocalized with matrix metalloprotease 13 (MMP13) and with activated ext

33 dependent fashion, whereas it down-regulated matrix metalloprotease-13 (MMP13), thus favoring scarrin

34 ion markers, including alkaline phosphatase, matrix metalloproteases-13, osteocalcin, and runx2, and

35 at L1 interacts with the ANT binding partner matrix metalloprotease 14 (MMP14) and that the ANT prote

36 of ADAM17 (TNF-alpha converting enzyme) and matrix metalloprotease 14 caused by a reduction in the e

37 including Cadherin 6, CollagenXXValpha1, and Matrix metalloprotease 17, that are selectively expresse

38 Matrix metalloprotease 2 (MMP-2) and cathepsin S were pr

39 h the activated form of purified recombinant matrix metalloprotease 2 (MMP-2) and had type IV collage

40 lts from the up-regulation and activation of matrix metalloprotease 2 (MMP-2) in tumor cells.

41 to a bioactive variant by incorporation of a matrix metalloprotease 2 (MMP-2) specific cleavage site

42 ed invadopodium function via upregulation of matrix metalloprotease 2 (MMP2) and MMP9 expression leve

43 loprotease 9 (MMP9) as well as activation of matrix metalloprotease 2 (MMP2) and MMP9, whereas the ED

44 MMP-12 inhibitor, was derived from a potent matrix metalloprotease 2 and 13 inhibitor via lead optim

45 sulted in decreased alphavbeta3 integrin and matrix metalloprotease 2, suggesting that the leptin sig

46 nectin and collagen-1, and activation of pro-matrix metalloprotease 2.

47 ion kinase phosphorylation and expression of matrix metalloproteases 2 and 9, both downstream mediato

48 We demonstrate that matrix metalloproteases 2, 8, and 15 were able to releas

49 et-derived growth factor subunit B) and MMP (matrix metalloprotease) 2/MMP14.

50 tric oxide (NO) production, which stimulates matrix metalloprotease-2 (MMP-2) and MMP-9 activity in t

51 te an annexin V-dependent externalization of matrix metalloprotease-2 (MMP-2) for reconfiguring the e

52 gments (Fn-f) associated with the proform of matrix metalloprotease-2 (MMP-2) in conditioned medium o

53 Ang2 was overexpressed, increased levels of matrix metalloprotease-2 (MMP-2) were also apparent.

54 es glioma invasion through the activation of matrix metalloprotease-2 (MMP-2).

55 We have shown that matrix metalloprotease-2 (MMP2) cleaves laminin-5 (Ln-5)

56 Specific cleavage of laminin-5 (Ln-5) by matrix metalloprotease-2 (MMP2) was shown to induce migr

57 he extracellular matrix, including Twist and matrix metalloprotease-2 (MMP2).

58 elicited upregulation of tissue inhibitor of matrix metalloprotease-2 (TIMP2).

59 s of angiogenesis, including angiopoietin-1, matrix metalloprotease-2, and hypoxia-inducible factor 1

60 tified five common targets: tenascin-C(TNC), matrix metalloprotease-2, collagen-6-A1, mannosidase-alp

61 xpression of alpha-SMA, collagen alpha1 (I), matrix metalloprotease-2, or tissue inhibitor of metallo

62 he protease responsible for IAP cleavage was matrix metalloprotease-2.

63 growth factor, matrix metalloprotease-9, and matrix metalloprotease-2.

64 orylation and slow degradation of lamin-A by matrix-metalloprotease-2 (MMP2), and inhibition of this

65 Matrix metalloprotease-20 (Mmp20) is the predominant enz

66 MMP23 (matrix metalloprotease 23) contains a domain (MMP23(TxD)

67 n is critically regulated by the activity of matrix metalloprotease 3 (MMP-3), in contrast to NMDAR-d

68 he nuclear factor kB-dependent activation of matrix metalloprotease 3 (MMP3/stromelysin1) was replica

69 Here, we identify matrix metalloprotease 7 (MMP7) as a key downstream effe

70 Of the identified proteins, matrix metalloprotease 7 (MMP7) showed the strongest ass

71 ted by the use of inhibitors directed toward matrix metalloprotease 8, matrix metalloprotease 9, or p

72 The enzymes responsible for generating PGP, matrix metalloproteases 8 and -9 and prolyl endopeptidas

73 d in PGP generation from collagen, involving matrix metalloproteases 8 and 9 and prolyl endopeptidase

74 We report that matrix metalloprotease-8 (MMP8) depletion or inhibition

75 The collagenase matrix metalloprotease 9 (MMP-9), which is increased in

76 d expression of a RHAMM target gene encoding matrix metalloprotease 9 (MMP-9).

77 LPS also induced expression of matrix metalloprotease 9 (MMP9) and failed to induce CD2

78 production, NO-dependent S-nitrosylation of matrix metalloprotease 9 (MMP9) as well as activation of

79 unteracted the effects of TGF-B1 by inducing matrix metalloprotease 9 (MMP9) expression while repress

80 , and is mediated by proteolytic activity of matrix metalloprotease 9 (MMP9).

81 f NF-kappaB and the expression of its target matrix metalloprotease 9 (MMP9).

82 ed an angiogenic response by upregulation of matrix metalloprotease 9 and endothelial and mesangial m

83 creased expression of NF-kappaB target genes matrix metalloprotease 9 and interleukin 6.

84 on, activation of p38MAPK, and production of matrix metalloprotease 9 are possible mechanisms for pro

85 (1607)-T(1608) peptide bond; cathepsin G and matrix metalloprotease 9 cleave VWF substrates at the Y(

86 ancer cells with a corresponding increase in matrix metalloprotease 9 enhanced hypoxia-induced GLUT1

87 IL-8, thymic stromal lymphoprotein, and pro-matrix metalloprotease 9 release.

88 , anti-inflammatory (IL-10), and fibrogenic (matrix metalloprotease 9) gene expression was increased

89 giogenic proteins like Galectin 3 and MMP-9 (Matrix Metalloprotease 9) in cervical carcinoma cells.

90 Expression of gelatinase B (matrix metalloprotease 9) in human placenta is developme

91 kout mouse, oxidative stress activated MMP9 (matrix metalloprotease 9) via its redox-responsive regul

92 P2 undergoes activity-dependent ES via MMP9 (matrix metalloprotease 9), and CNTNAP2-ecto levels are r

93 , c-myc, vascular endothelial growth factor, matrix metalloprotease 9).

94 y response genes, including TNF-alpha, CCL3, matrix metalloprotease 9, integrin alpha(M), and Bcl-X i

95 rs directed toward matrix metalloprotease 8, matrix metalloprotease 9, or prolyl endopeptidase.

96 alloprotease activity, including activity of matrix metalloprotease 9.

97 regulating the Mr 92,000 type IV collagenase matrix metalloprotease-9 (MMP-9) and in vitro invasivene

98 d using BrdU incorporation and both TrkA and matrix metalloprotease-9 (MMP-9) expression were measure

99 sent study, we investigate the potential for matrix metalloprotease-9 (MMP-9), an endopeptidase secre

100 r differentially expressed transcript, mouse matrix metalloprotease-9 (MMP-9).

101 ressed the DMBA-induced cyclooxygenase-2 and matrix metalloprotease-9 expression in the breast tumor.

102 gulation of NF-kappaB, cyclooxygenase-2, and matrix metalloprotease-9 expression.

103 Infected Wsh mice had reduced amounts of matrix metalloprotease-9 in BALF and were resistant to e

104 Matrix metalloprotease-9 may thus enhance overall excita

105 vivo, sIL-6R and LPS augmented amniochorion matrix metalloprotease-9 release, whereas sgp130 opposed

106 l and LPS-stimulated release of amniochorion matrix metalloprotease-9 was tested ex vivo.

107 [VEGF-A], stromal cell-derived factor-1, and matrix metalloprotease-9) and proangiogenic macrophage/m

108 M-1, vascular endothelial growth factor, and matrix metalloprotease-9) gene products.

109 ar endothelial growth factor), and invasion (matrix metalloprotease-9).

110 ity of TIMP-1 at its canonical target MMP-9 (matrix metalloprotease-9).

111 sential for the efficient early induction of matrix metalloprotease-9, a known mediator of extracellu

112 xpression of basic fibroblast growth factor, matrix metalloprotease-9, and matrix metalloprotease-2.

113 ced NF-kappaB-dependent reporter gene and of matrix metalloprotease-9, cyclooxygenase-2, and cyclin D

114 Our data suggest that this protease, matrix metalloprotease-9, increases branching of excitat

115 as also necessary for TNF-induced release of matrix metalloprotease-9, thought to be an essential reg

116 Known LRP1 ligands, including matrix metalloprotease-9, tissue-type plasminogen activa

117 (CCL-2), and RANTES (CCL-5), as well as the matrix metalloprotease-9.

118 ducts cyclin D1, cyclooxygenase (COX)-2, and matrix metalloprotease-9.

119 Consistently, IL-17 upregulated matrix-metalloprotease-9 and neutrophil elastase express

120 pwise cascade of protease activation wherein matrix metalloproteases activate effector caspases, lead

121 Furthermore, AQP-1 enhances matrix metalloprotease activity and colocalizes with pho

122 uring invasion in Matrigel, the secretion of matrix metalloprotease activity and migration in a modif

123 Because osteonectin specifically enhances matrix metalloprotease activity in prostate and breast c

124 ficantly reduced tumor cell invasiveness and matrix metalloprotease activity in the coculture superna

125 Treatment with IL-1 significantly increased matrix metalloprotease activity in the conditioned media

126 astic fiber disruption with age, and vaginal matrix metalloprotease activity was increased significan

127 nse to TSP1 or its EGF-like repeats required matrix metalloprotease activity, including activity of m

128 aneurysm by enhancing cellular apoptosis and matrix metalloprotease activity.

129 essive cancer cells degraded prolargin using matrix metalloprotease activity.

130 The EGFR ligands are known substrates of the matrix metalloprotease ADAM17, suggesting stretch activa

131 e levels of collagenolytic activity of MMPs (matrix metalloproteases), along with a significant reduc

132 joints as well as by increased expression of matrix metalloproteases and bone-specific proteases.

133 Both SF-resident matrix metalloproteases and cathepsins have been implica

134 th fibrosis and tissue remodeling, including matrix metalloproteases and collagen, were upregulated i

135 ctin-rich protrusive organelles that secrete matrix metalloproteases and degrade the extracellular ma

136 innate immune cells, elevated activities of matrix metalloproteases and increased angiogenesis and v

137 oactivator p300, preventing the induction of matrix metalloproteases and other p300-dependent genes r

138 facilitating invasion through expression of matrix metalloproteases and synthesis of interleukin 6 (

139 Synergy between inhibitors of matrix metalloproteases and TMPRSS2 suggests that both h

140 gment is generated at the plasma membrane by matrix metalloproteases and transferred to the cell nucl

141 en engineered requirements for activation by matrix metalloproteases and urokinase plasminogen activa

142 ystems-BMP-1/TLD (tolloid) (astacins), MMPs (matrix metalloproteases) and the ADAMs (disintegrin/meta

143 inly in the connective tissue (predominantly matrix metalloproteases) and, to some extent, in the epi

144 of the unc-5 netrin receptor and zmp-1 zinc matrix metalloprotease, and in cell morphology.

145 tin, TGF-beta1, collagen I, fibronectin, and matrix metalloproteases, and plasma PAI-1 levels correla

146 against other zinc-dependent enzymes such as matrix metalloproteases, and possessed limited cytotoxic

147 n and LPS up-regulate chemokines, cytokines, matrix metalloproteases, and PTGS/COX2, consistent with

148 expression of the M-CSF receptor c-Fms by a matrix metalloprotease- and MAPK-dependent mechanism.

149 ace expression on human neutrophils, whereas matrix metalloproteases are dispensable.

150 nitiate dendrite breakage, and extracellular matrix metalloproteases are required to degrade the seve

151 We observe increased expression of matrix metalloproteases as well as decreased expression

152 g., for the thrombin receptor, inhibition of matrix metalloproteases blocked IL-8-mediated cell migra

153 ue-specific proteases, including complement, matrix metalloproteases, caspases, and granzymes, and ca

154 Here we show that matrix-metalloprotease-cleaved Col I (cCol I) and intact

155 eness of the tumor cells in a TNF-alpha- and matrix metalloprotease-dependent manner.

156 ted through an autocrine mechanism involving matrix metalloprotease-dependent release of heparin-bind

157 rends and selectivity profiles against other matrix metalloproteases despite their close structural s

158 o breach basement membrane in the absence of matrix metalloproteases during its developmental invasio

159 promoted invasiveness indirectly by inducing matrix metalloprotease enzyme 9 production, whereas drug

160 is a glycosylphosphatidyl inositol-anchored matrix metalloprotease expressed on the surface of cance

161 NF-a inhibited ND- and T2DM-DF migration and matrix metalloprotease expression to the same degree, al

162 geting metastatic spread using inhibitors of matrix metalloproteases failed to deliver the promise of

163 is cleaved by members of the disintegrin and matrix-metalloprotease family that are increased in the

164 os-dependent transcriptional activation of a matrix metalloprotease gene mmp1 downstream of JNK.

165 r--as well as the wide-spectrum inhibitor of matrix metalloproteases, GM6001.

166 gh the role of selected serine proteases and matrix metalloproteases in chemokine processing has long

167 ermore, RNF213 down-regulated expressions of matrix metalloproteases in endothelial cells, but not in

168 strated that TWEAK induced the production of matrix metalloproteases in human chondrocytes and potent

169 itively with 1-NM-PP1, indicating a role for matrix metalloproteases in TrkA activation.

170 uggest that although activation of all known matrix metalloproteases in vitro is accomplished by prot

171 nally, studies using selective inhibitors of matrix metalloproteases indicated that they and heparin-

172 s, we found that targeting the extracellular matrix metalloprotease inducer (EMMPRIN) by injecting na

173 y mediators that stimulate the production of matrix metalloprotease, inflammatory cell recruitment, a

174 -plasmin, an inhibitor of plasmin, or by the matrix metalloprotease inhibitor 1,10 phenanthroline.

175 A key intermediate in the synthesis of a matrix metalloprotease inhibitor has been achieved using

176 Endogenous matrix metalloprotease inhibitor TIMP-3 inhibited activi

177 The general matrix metalloprotease inhibitor, GM6001, blocked agonis

178 Actinonin, a non-specific matrix metalloprotease inhibitor, improved recovery of t

179 Matrix metalloprotease inhibitors suppressed S-mediated

180 X-73-4 or by 1,10-phenanthroline, but not by matrix metalloprotease inhibitors.

181 e relationship of Pneumocystis colonization, matrix metalloprotease levels in sputum, and airway obst

182 regulatory pathways involving inhibition of matrix metalloproteases, liver X receptor/retinoid X rec

183 e proteins in PDAC tumours and revealed that matrix-metalloprotease-mediated shedding of the AXL rece

184 urther analysis highlighted induction of the matrix metalloprotease MMP-10 and the extracellular matr

185 cells also led to increased secretion of the matrix metalloprotease MMP-9.

186 olar septal cell apoptosis and activation of matrix metalloproteases MMP-9 and MMP-2.

187 extracellular matrix proteases ADAMTS-5 and matrix metalloprotease (MMP) -3, -7, and -13.

188 showed that exogenous addition of activated matrix metalloprotease (MMP) 2 stimulates migration onto

189 lox/flox) mice is characterized by excessive matrix metalloprotease (MMP) activity, reduced lung elas

190 onents of the plasminogen activator (PA) and matrix metalloprotease (MMP) cascade have been character

191 d according to the need of the cell by using matrix metalloprotease (MMP) cleavable peptide sequences

192 we explored how the epigenome contributes to matrix metalloprotease (MMP) dysregulation impacting tum

193 cleavage site motifs for six enzymes in the matrix metalloprotease (MMP) family.

194 Young and aged mice were treated with a matrix metalloprotease (MMP) inhibitor and systemic sFas

195 howed that cold causes actin disassembly and matrix metalloprotease (MMP) secretion by SEC, we also q

196 g site-masking peptide to the antibody via a matrix metalloprotease (MMP) susceptible linker.

197 We now identify the metalloprotease MT1-matrix metalloprotease (MMP), an integral membrane prote

198 vity caused the expression and activation of matrix metalloprotease (MMP)-1 and MMP-9, which in turn

199 Surface expression of matrix metalloprotease (MMP)-14 on ovarian cancer cells

200 Matrix metalloprotease (MMP)-14-mediated Tie2 ectodomain

201 Although matrix metalloprotease (MMP)-2 and -9 are involved in bo

202 The type IV collagenases matrix metalloprotease (MMP)-2 and MMP-9 are linked with

203 on of angiogenesis ( approximately 40%) in a matrix metalloprotease (MMP)-2-deficient mouse compared

204 oth the expression and enzymatic activity of matrix metalloprotease (MMP)-9 and MMP-2, two pro-angiog

205 mpromised elastic fibers and upregulation of matrix metalloprotease (MMP)-9.

206 onths and were analysed for a panel of novel matrix metalloprotease (MMP)-degraded ECM proteins, by E

207 Matrix metalloprotease (MMP)-degraded type I collagen (C

208 cell interfaces accompanied by inhibition of matrix metalloprotease (MMP)-dependent shedding of the D

209 In response to PR-induced Wnt-1 signaling, matrix metalloprotease (MMP)-mediated membrane-proximal

210 ole of biomaterial design in BMP delivery, a matrix metalloprotease (MMP)-sensitive hyaluronic acid (

211 VEGF, nitrotyrosine, and membrane-type (MT1) matrix metalloprotease (MMP).

212 ed bone loss in Smoc2(-/-) mutants, reducing matrix metalloprotease (Mmp)9.

213 Here, we examined the expression of matrix metalloproteases (MMP) -2, -3, -9, -12, and -13 a

214 sites of ECM degradation where activation of matrix metalloproteases (MMP) occurs.

215 ibition results in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type 1-MMP

216 Matrix metalloproteases (MMP)-9 and cathepsin B have bee

217 sed their phagocytic rate, without affecting matrix metalloproteases (MMP)2 and MMP9 activity.

218 Further, we show that the matrix metalloprotease, MMP-1, functions as a protease a

219 ion, and also downregulates the pro-invasive matrix metalloprotease, MMP-2.

220 astrocytic water channel protein, AQP-4, and matrix metalloprotease, MMP-9.

221 JNK signaling activates a matrix metalloprotease (MMP1) to promote Notch-induced t

222 increase in the activity of membrane type-1 matrix metalloprotease (MMP14, MT1-MMP) by heterotrimeri

223 ribes the characterization of the Drosophila matrix metalloprotease Mmp2 as an extracellular inhibito

224 markers FN, Snail, N-cadherin, vimentin, the matrix metalloprotease MMP2, alpha-smooth muscle actin a

225 matory responses such as upregulation of the matrix metalloprotease MMP9, and increases angiogenesis

226 tential, by decreasing the expression of the matrix metalloprotease MMP9.

227 ulated induction, in cardiac fibroblasts, of matrix metalloproteases (MMPs) 9 and 13-MMPs linked to g

228 in a process that requires ECM remodeling by matrix metalloproteases (MMPs) [2-4].

229 atrix-degrading enzyme expression, including matrix metalloproteases (MMPs) and a disintegrin-like an

230 Matrix metalloproteases (MMPs) are a group of zinc-depen

231 Matrix Metalloproteases (MMPs) are an important family o

232 Matrix metalloproteases (MMPs) are broad-spectrum protea

233 Matrix metalloproteases (MMPs) are endopeptidases that r

234 Matrix metalloproteases (MMPs) are responsible for the b

235 Matrix metalloproteases (MMPs) are typically associated

236 Matrix metalloproteases (MMPs) are Zn-containing endopep

237 ffect of their interaction on the release of matrix metalloproteases (MMPs) from chondrocytes.

238 Matrix metalloproteases (MMPs) have attracted considerab

239 Matrix metalloproteases (MMPs) have recently emerged as

240 Conversely, the activity of matrix metalloproteases (MMPs) is essential for the late

241 The group of matrix metalloproteases (MMPs) is responsible for multip

242 Matrix metalloproteases (MMPs) MMP-2 and MMP-9 have been

243 Matrix metalloproteases (MMPs) play a role in remodeling

244 Matrix metalloproteases (MMPs) play important roles in n

245 Matrix metalloproteases (MMPs) regulate innate immunity

246 Therapeutically inhibiting matrix metalloproteases (MMPs) suppressed both IMPAD1- a

247 an-1 cleavage is mediated by upregulation of matrix metalloproteases (MMPs) that accompanies higher H

248 ACE inhibition, but reducing potency against matrix metalloproteases (MMPs) thus increasing overall s

249 Applied to matrix metalloproteases (MMPs) with highly conserved cat

250 We examined the role of matrix metalloproteases (Mmps), and found that reducing

251 been synthesized, evaluated as inhibitors of matrix metalloproteases (MMPs), and found to display rem

252 Integrins, matrix metalloproteases (MMPs), and the cytokine TGF-bet

253 d t-SP depends on extracellular signaling by matrix metalloproteases (MMPs), but it is unknown how th

254 rface of cells is sensitive to cleavage with matrix metalloproteases (MMPs), this study examined whet

255 Matrix metalloproteases (MMPs), which are induced by tra

256 arge variety of mediators, including several matrix metalloproteases (MMPs), which participate in fib

257 microtubule track for localized secretion of matrix metalloproteases (MMPs).

258 , fibrillar collagen is degraded by specific matrix metalloproteases (MMPs).

259 he ECM, and cleavage of VEGF from the ECM by matrix metalloproteases (MMPs).

260 ate the extracellular levels of gelatinases (matrix metalloproteases, MMPs) and potentially influence

261 ses, including neutrophil elastase and MMPs (matrix metalloproteases), modulate cell signaling, infla

262 anges in macrophage cytokine, chemokine, and matrix metalloprotease mRNA, and protein-inducing mediat

263 The membrane-anchored matrix metalloprotease MT1-MMP is a potent collagenolyti

264 Membrane type 1-matrix metalloprotease (MT1-MMP or MMP-14) is a major ac

265 Membrane Type 1 Matrix Metalloprotease (MT1-MMP) contributes to the inva

266 crovesicle cargo such as the membrane-type 1 matrix metalloprotease (MT1-MMP) to shedding microvesicl

267 n secretion from the cell by membrane type 1 matrix metalloprotease (MT1-MMP), affording the 8 and 5

268 ity, dependent on the enzyme membrane type I matrix metalloprotease (MT1-MMP), and that DC transientl

269 s (EECs) of critical cargos (membrane-type 1 matrix metalloprotease [MT1-MMP] and beta3 integrin) req

270 b27-dependent recycling of the transmembrane matrix metalloprotease, MT1-MMP to promote invasive beha

271 es the matrix invasion activity by recycling matrix metalloprotease, MT1-MMP.

272 ed to serine hydrolases, cysteine proteases, matrix metalloproteases, nitrilases, caspases, and histo

273 cleavage of an intact mannose receptor by a matrix metalloprotease or ADAM metalloprotease.

274 ificantly inhibit the 10 most abundant human matrix metalloproteases or complement-mediated cell lysi

275 y 12-fold) the TNF-specific peptide over the matrix metalloproteases peptide in vitro.

276 rotubule integrity, as well as by modulating matrix metalloprotease processing.

277 mitogenesis of articular cells and stimulate matrix metalloprotease production, thus promoting degrad

278 Matrix metalloproteases promote tumor cell invasion, epi

279 in vivo and that inhibition of ROCK but not matrix-metalloproteases reduces cancer cell motility in

280 Matrix metalloproteases regulate both physiological and

281 nalogous to the cysteine switch mechanism of matrix metalloprotease regulation.

282 cue-induced synaptic enlargement depends on matrix metalloprotease signaling in the extracellular ma

283 orms these methods in predicting caspase and matrix metalloprotease substrate-cleavage sites.

284 ptides, peptide hormones, growth factors and matrix metalloprotease substrates, neuropeptides, amyloi

285 Metastasizing tumor cells use matrix metalloproteases, such as the transmembrane colla

286 Matrilysin is a matrix metalloprotease that is overexpressed in cancer c

287 Type IV 72-kDa collagenase is one of the matrix metalloproteases that has been implicated in diff

288 t) decreased, consistent with an increase in matrix metalloproteases throughout the leaflet.

289 imilar to that found in tissue inhibitors of matrix metalloproteases (TIMPs) and in complement factor

290 I), as well as by an endogenous inhibitor of matrix metalloproteases, tissue inhibitor of metalloprot

291 ate that NG2+ cells, but not astrocytes, use matrix metalloproteases to extend across a region of inh

292 d their shared susceptibility to cleavage by matrix metalloproteases to generate circulating collagen

293 Matrix metalloprotease type 9 (MMP-9) has been functiona

294 The upregulation of DC-STAMP and matrix metalloproteases was observed on these cells and

295 s, including chemokines, growth factors, and matrix metalloproteases, was increased, a signature rese

296 pus, including the up-regulation of multiple matrix metalloproteases, which are known to be critical

297 Because TIMP-1 inhibits most matrix metalloproteases, which are responsible for colla

298 phosphorylation of DDRs is known to activate matrix metalloproteases, which in turn cleave the ECM.

299 Further, blockade of matrix metalloprotease with BB-94 inhibited eotaxin-1-in

300 ealed that the protrusion is enriched in the matrix metalloprotease ZMP-1 and transiently expands AC