ライフサイエンスコーパス: maturation

1 evelopment and persists even after continued maturation.

2 ex-structured migration, and delayed plumage maturation.

3 the influence of cannabis and NTP co-use on maturation.

4 vel clinical tools to predict successful AVF maturation.

5 A) cycle enzyme levels, and triggers synapse maturation.

6 ncluding proliferation, differentiation, and maturation.

7 sh border membrane, junctional polarity, and maturation.

8 to potent antigen-presenting cells upon full maturation.

9 heterochromatic silencing and male germline maturation.

10 tly reduces oligodendrocyte iron storage and maturation.

11 so decorates SG membranes and facilitates SG maturation.

12 a prolonged differentiation, migration, and maturation.

13 herapy on primary murine fistula patency and maturation.

14 ation is both repressed and activated during maturation.

15 ed in the control of mitochondrial metabolic maturation.

16 rdiomyopathy with an arrest in mitochondrial maturation.

17 ring during postnatal periods of hippocampal maturation.

18 ture, mechanism, alternative reactivity, and maturation.

19 ions and the heterochrony of their postnatal maturation.

20 slational protein folding, localization, and maturation.

21 l transition coincides with action potential maturation.

22 bryo morphogenesis, photosynthesis, and seed maturation.

23 nts have significantly reduced Nmnat protein maturation.

24 bilizes the productive conformation to allow maturation.

25 tional repressor and activator during oocyte maturation.

26 underlies iNKT cell development and effector maturation.

27 pected function for TruB1 in promoting let-7 maturation.

28 e whisky was observed around twelve years of maturation.

29 O-spindle coupling strength increases during maturation.

30 into GCs to initiate the process of affinity maturation.

31 and destinations change progressively during maturation.

32 MDSs causes anemia due to impaired erythroid maturation.

33 to adult state and this drives cardiomyocyte maturation.

34 ules form by cell coalescence and structural maturation.

35 inian evolutionary process known as affinity maturation.

36 childhood, even if still subject to ongoing maturation.

37 g and challenge current models of telomerase maturation.

38 r some individuals, consistent with affinity maturation.

39 sertion/deletion (U-indel) editing for their maturation.

40 e also showed higher NPC differentiation and maturation.

41 ing in metabolome and proteome during oocyte maturation.

42 vated B cells inhibitor that blocks IL-1beta maturation.

43 , thereby controlling the timing of neuronal maturation.

44 pment, including axon outgrowth and neuronal maturation.

45 gests possible remobilization of soma during maturation (a "capital" source).

46 ship between Notch signaling and goblet cell maturation, a feature of BE, during EAC pathogenesis.

47 roline hydroxylation within, and proteolytic maturation after exit from the Golgi.

48 that MCM10 is required for NK cell terminal maturation and acquisition of immunological system funct

49 T cell maturation and activation depend upon T cell receptor (T

50 pical zonated metabolic enzymes during liver maturation and after acute injury induced by carbon tetr

51 up by dendritic cells (DCs) and promoted DC maturation and antigen presentation.

52 inevitably arise during A. fumigatus biofilm maturation and are both critical for, and the result of,

53 We monitored microbiota maturation and associations with subsequent development

54 ein synthesis that trigger impaired synaptic maturation and autistic behaviors.

55 act cooperatively to regulate cardiomyocyte maturation and cell cycle.

56 ctrical activity that is critical for proper maturation and circuit refinement.

57 ad4-mediated signaling drives the functional maturation and connectivity of basal VSNs.

58 cells; this resulted in inhibition of miR-16 maturation and consequently led to increased JNK2 protei

59 h of the Ab diversity necessary for affinity maturation and effective humoral immunity.

60 ation by 1,25(OH)(2)-D(3) was independent of maturation and expression levels of microRNA-155 and PU.

61 ADAM17 maturation and function depend on the seven-membrane-spa

62 hat primary cilia are important for neuronal maturation and function in cells of the SC and dLGN.

63 e to this collateral damage influences brain maturation and function remains unknown.

64 R protein Protrudin orchestrates invadopodia maturation and function.

65 g, resulting in aberrations in T- and B-cell maturation and function.

66 ins and accumulation of mutations with aging/maturation and has implications for delayed reproduction

67 se IGHV3-53 antibodies show minimal affinity maturation and high potency, which is promising for vacc

68 axonal navigation also play roles in synapse maturation and homeostasis.

69 Here we describe the affinity maturation and humanization of a rabbit mAb that binds h

70 r system for the assessment of cardiomyocyte maturation and identified potent maturation-enhancing EC

71 learning impairs both AMPA receptor response maturation and infantile memory, indicating that the syn

72 ic coexpression clusters associated with MPS maturation and innate immune function.

73 y open new possibilities for accelerating RT maturation and interfering with viral replication.

74 rom identifying the developmental drivers of maturation and leveraging them to create more mature car

75 mts19-Klf2 axis is required for proper valve maturation and maintenance.

76 Nevertheless, maturation and migration of LC lacking E-cadherin was no

77 LV-1 infection, whereas enhanced CD4+ T cell maturation and monocyte aggregation are features of HAM,

78 nt promotes oligodendrocyte progenitor cells maturation and myelin regeneration across the remyelinat

79 This temporal disparity between prepartum maturation and neonatal upregulation of mitochondrial ox

80 tical deep-layer neurons, increased synaptic maturation and number of astroglial cells.

81 cently reported to be involved in melanosome maturation and pigmentation.

82 he role of small terminase proteins in viral maturation and presents the structure of TerS(P76-26), r

83 ecular chaperones involved in normal protein maturation and refolding malformed proteins through the

84 key pathways regulating myeloid cell cycle, maturation and regenerative function of the epithelial n

85 aining 3 (NLRP3) inflammasome to trigger the maturation and release of the inflammatory cytokine inte

86 inning IL-1alpha, IL-1beta, IL-18, and IL-37 maturation and release; and the functions of these cytok

87 propose that complex III is central for MRC maturation and SC formation.

88 IL-1beta, IL-18, and IL-37 maturation and secretion is governed by inflammatory cas

89 that plays an essential role in T lymphocyte maturation and selection during development of one arm o

90 e this is an important period for both brain maturation and social relations.

91 AMP rise at maturation onset rescued meiotic maturation and spawning.

92 major hallmarks of ventricular cardiomyocyte maturation and summarize key regulatory mechanisms that

93 ng (PV+) interneurons play a key role in the maturation and synchronization of cortical circuitry and

94 Affinity maturation and terminal differentiation of B-cells via t

95 orphological traits associated with pericyte maturation and uncover PI3Kbeta activity as a checkpoint

96 rs in three stages: cell attachment, biofilm maturation, and biofilm dispersal.

97 axonal regeneration, neuromuscular junction maturation, and functional recovery of injured sciatic n

98 eptidase 28 (ADAM28), were expressed upon IS maturation, and OVCH2 was required for processing of the

99 ion of long 5'-flaps during Okazaki fragment maturation, and that the essential function of Dna2 is t

100 Synapse formation, maturation, and turnover require a finely regulated tran

101 that CcmI interacts with SirEFG during SirA maturation, and with CcmF during maturation of NrfA.

102 B cell maturation antigen (BCMA) is expressed only on plasma ce

103 luster of differentiation 3 (CD3) and B-cell maturation antigen (BCMA).

104 The anti-B-cell maturation antigen BiTE molecule AMG 420 was assessed in

105 857916), an immunoconjugate targeting B-cell maturation antigen, showed single-agent activity in the

106 purified components.IMPORTANCE Assembly and maturation are essential steps in the replication of ort

107 also must transition prior to further viral maturation, assembly, and release, implying additional s

108 Unassisted AVF maturation associated with preoperative arterial diamete

109 differentially express genes related to ECM maturation at P7 and immune crosstalk at P30.

110 nly contribute to filamentous fungal biofilm maturation but also drive resistance to antifungal treat

111 with theories of accelerated and/or delayed maturation, but may also involve anomalous developmental

112 rall, our data show that inhibition of HIV-1 maturation by BVM involves changes in structure and dyna

113 ause reduced cardiomyocyte proliferation and maturation by disrupting fibronectin-integrin signaling,

114 ose that GTPBP5 primarily fuels proper mtLSU maturation by securing efficient methylation of two 16S

115 tudies reveal a novel role of UBR5 in B-cell maturation by stabilization of spliceosome components du

116 ld on existing knowledge about primary miRNA maturation by the Microprocessor and further explore the

117 Lymphoma-intrinsic MYC arrests NK maturation by transcriptionally repressing STAT1/2 and s

118 .SIGNIFICANCE STATEMENT Studying hippocampal maturation can provide insight into episodic memory deve

119 d into adolescence, studying episodic memory maturation can provide insight into the development and

120 Pravastatin modulated phagosomal maturation characteristics in macrophages, phenocopying

121 Here, we describe the identification, maturation, characterization, and utilization of a CDP t

122 onally distinct nucleoprotein complexes; the maturation complex and the packaging motor complex, resp

123 on the assembly of a catalytically competent maturation complex on viral DNA, their effect on maturat

124 ration complex on viral DNA, their effect on maturation complex stability and their requirement for t

125 expressed in immature cDC1s but repressed on maturation, concomitant with Mxd1 induction in mature cD

126 Affinity maturation continued for 6 to 9 mo following vaccination

127 This maturation defect resulted in excess immature neuronal s

128 ined increased attention recently due to the maturation defects in pluripotent stem cell-derived card

129 9 degrees Brix as the most appropriate grape maturation degree to obtain a greater number of volatile

130 ted targets reflect the role of ABI3 in seed maturation, desiccation tolerance, entry into a quiescen

131 B cells also cannot complete CSR or affinity maturation despite accumulating significant mutations in

132 lopment of diffuse WMI: poor oligodendrocyte maturation, diffuse axonal hypomyelination, and permanen

133 BAergic cortical interneurons interacts with maturation during adolescence has not been clarified yet

134 The kinetics of IgG avidity maturation during SARS-CoV-2 infection was studied.

135 rdiomyocyte maturation and identified potent maturation-enhancing ECMs through this simple and rapid

136 ng and often present challenges in comparing maturation-enhancing strategies.

137 benefit the understanding about the vesicles maturation, especially involving the "sorting by retenti

138 DUOX1 co-assembles with its maturation factor DUOXA1 to form an active enzyme comple

139 Furthermore, our results suggest maturation failure and immune reaction response as the m

140 e sequential processes of HIV-1 assembly and maturation from purified components.IMPORTANCE Assembly

141 Interestingly, whereas NK cell functional maturation from stage 3 and 4A NKDIs was independent of

142 nscriptional landscape that highlights their maturation, function, and fate decisions at homeostasis.

143 Cardiomyocyte maturation gained increased attention recently due to th

144 latory genes (Cd274, Pdcd1lg2 and Cd200) and maturation genes (Cd40, Ccr7 and Il12b).

145 evelopmental disruption of prefrontal cortex maturation has been implicated in the pathophysiology of

146 n CNS angiogenesis and neurovascular barrier maturation have been elucidated in recent years.

147 plex member 10 (MCM10) that impaired NK cell maturation in a child with fatal susceptibility to CMV.

148 e report the first evidence of male-mediated maturation in a wild primate, the gelada (Theropithecus

149 ines the role of NFU1 in Fe-S client protein maturation in Arabidopsis chloroplasts among other SUF c

150 affect larval survival in rivers, growth and maturation in lakes, phenology and the spawning migratio

151 ation, while groEL1 was required for biofilm maturation in M. smegmatis.

152 th an atypical profile of this developmental maturation in model-based control.

153 of which substantially delays cardiomyocyte maturation in postnatal hearts, and markedly enhances ca

154 that STAT5b is involved in terminal NK cell maturation in Stat5b(-/-) mice.

155 re this antimicrobial potential during their maturation in the bone marrow, where they differentiate

156 28 period would affect synapse formation and maturation in the developing hippocampus.

157 3 cKO mice exhibit increased dendritic spine maturation in the ventral CA1 hippocampal subregion.

158 Estimated age at dental maturation in this fossil hominin compares well with wha

159 his superfamily are key in triggering sexual maturation in vertebrates but also regulate reproductive

160 We report that, upon developmental maturation, in mice 30% of the IHCs are electrochemicall

161 ually all aspects of postnatal developmental maturation, including mitochondrial energy transduction,

162 perimental arteriovenous fistula patency and maturation, indicating that additional clinical evaluati

163 mal trafficking genes required for proper SG maturation, indicating that maturation of SGs might occu

164 t they were both strongly implicated in moDC maturation induced by IFX aggregates.

165 r the HIV-1 protein NEF in preventing B-cell maturation into antibody-producing plasma cells.

166 tigen because they continued to drive T cell maturation into CXCR5+PD-1+ T follicular helper cells.

167 tween the substrate and MSFs, allowing their maturation into sarcomere-containing myofibrils.

168 s labile, demonstrating that floral meristem maturation involves the stabilisation of positional info

169 Dendritic cell (DC) maturation is a prerequisite for the induction of adapti

170 structures known as perineuronal nets whose maturation is associated with the end of early critical

171 In summary, proNGF maturation is impaired in preclinical and clinical AD wh

172 al control of blood vessel morphogenesis and maturation is linked to the pathogenesis of various neur

173 How this balance in maturation is maintained is unclear.

174 emory, indicating that the synapse formation/maturation is necessary for creating infantile memories.

175 As a step towards understanding how neuronal maturation is regulated, we studied the developmental sw

176 Maturation is the last phase of heart development that p

177 n, in turn, resulted in inhibition of miR-16 maturation, leading to upregulation of JNK2 expression,

178 We propose that a failure in iron protein maturation leads to early senescence of the bacteroids.

179 Energy disbalance and aberrant maturation likely hinder the integration of PV(+) intern

180 sembly of this cofactor requires a dedicated maturation machinery including HydF, a multidomain [4Fe4

181 sides, the variations of varietal or typical maturation markers did not have sensory importance.

182 he periplasm where it undergoes considerable maturation, modification, or degradation depending on th

183 tor signaling, upregulated an IRF8-dependent maturation module, and acquired antigens via convalescen

184 erone activity, and exhibit the hallmarks of maturation observed for SG proteins that phase-separate

185 young flies to sleep longer by delaying the maturation of a neural network that controls sleep.

186 expression of DICER, which promotes enhanced maturation of a set of cell-type-specific miRNAs.

187 nsistent with its known function in affinity maturation of antibodies and plasma cell survival.

188 of the UBR5 HECT domain leads to a block in maturation of B cells in the spleen and upregulation of

189 Chlamydial LOS was also a poor stimulator of maturation of bone marrow-derived dendritic cells compar

190 clear import of NP1, and plays a role in the maturation of capsid protein-encoding mRNAs in the nucle

191 erns of spontaneous spike activity drive the maturation of central auditory circuits.

192 ISC machinery and their contributions to the maturation of client [4Fe-4S] cluster-containing protein

193 sms are ill-defined, the differentiation and maturation of crossover-specific recombination intermedi

194 holoenzyme, GRXS17 is likely involved in the maturation of cytosolic and nuclear Fe-S proteins.

195 Maturation of DCs induced by diverse proinflammatory con

196 photodynamic therapy (PDT) and promoting the maturation of dendritic cells (DCs).

197 espiratory infection in mice, with increased maturation of dendritic cells and the induction of prote

198 show progressive changes in vasculature and maturation of dendritic-cell subsets with chronicity, wi

199 homosynaptic source of acetylcholine for the maturation of developing glutamatergic synapses.

200 g erythroid output as reflected by increased maturation of erythrocyte progenitors.

201 regulating steady-state differentiation and maturation of GM-CSF-dependent DCs are insufficiently kn

202 The maturation of high-frequency (basal) hair cells was also

203 eries involved in different steps during the maturation of major histocompatibility complex class I (

204 Here, we reconstituted the maturation of mitochondrial [4Fe-4S] aconitase without a

205 During nuclear maturation of most eukaryotic pre-messenger RNAs and lon

206 etase, an enzyme complex responsible for the maturation of multiple substrates, such as Abeta.

207 Molecular and functional maturation of neonatal mouse cardiomyocytes and human em

208 relevant to the brain while accelerating the maturation of neuronal networks, important features unde

209 receptors, contributes to the modulation and maturation of NGF, improving the regenerative properties

210 ow that in addition to the impaired terminal maturation of NK cells, human STAT5b mutation leads to i

211 This mutation, however, impaired the maturation of NLGN4 protein by inhibiting N-linked glyco

212 during SirA maturation, and with CcmF during maturation of NrfA.

213 The mechanisms responsible for the maturation of OHCs and their synaptic specialization rem

214 the bone marrow and/or spleen and inhibited maturation of pre-, immature, and transitional stage 2 B

215 d a protein kinase c activator that promotes maturation of pre-alpha cells into SC-alpha cells.

216 ZMPSTE24 performs a key proteolytic step in maturation of prelamin A, the farnesylated precursor of

217 to lumbar motoneurons, correlating with the maturation of premotor descending and local spinal syste

218 and ASC to activate caspase-1 and drive the maturation of proinflammatory cytokines IL-1beta and IL-

219 r modulator of merozoite invasion and direct maturation of proteins required for invasion, parasite d

220 ic ribonucleoprotein complex involved in the maturation of rRNA and the regulation of the cell cycle.

221 smic reticulum (ER) serves both as a hub for maturation of secreted proteins and as an intracellular

222 bined with ISR inhibition causes an impaired maturation of several tyrosine kinase receptors (RTKs),

223 ed for proper SG maturation, indicating that maturation of SGs might occur in a manner similar to lys

224 in the sir gene cluster is required for the maturation of SirA, but not NrfA.

225 SUFBC(2)D scaffold complex and serves in the maturation of specific [4Fe-4S] client proteins.

226 xtracts using the procedure which reproduces maturation of spirits.

227 fied several important roles of GluA3 in the maturation of synaptic transmission and short-term plast

228 sis reveals a progressive, ventral-to-dorsal maturation of telencephalic meninges.

229 myces cerevisiae, the complex life cycle and maturation of telomerase includes a cytoplasmic stage.

230 (n-3 PUFAs) are essential for the functional maturation of the brain.

231 role that experience exerts in promoting the maturation of the hippocampus-dependent memory system, r

232 The maturation of the mammalian brain occurs after birth, an

233 We discover that maturation of the microbiota drives the development of d

234 be effective [4Fe-4S](2+) cluster donors for maturation of the mitochondrial apo-aconitase 2 as asses

235 However, limited data exist on a healthy maturation of the oral microbial ecosystem in children.

236 Here, using an affinity maturation of the RLIP76 Ral-binding domain, we identifi

237 feration and differentiation, migration, and maturation of their progenies were evaluated at 2, 5, 14

238 peculiarities of these mitoribosomes and the maturation of their small subunit.

239 acers and electron microscopy to explore the maturation of this pathway.

240 networks control the lineage programming and maturation of thymic precursor cells.

241 broad effects on regulating neurogenesis and maturation of transmitter-specific neuronal types during

242 I for hexon binding facilitates the complete maturation of VI, and is responsible for releasing the l

243 arget cell, replication of the viral genome, maturation of viral proteins and genome packaging into i

244 Pentamidine-decreased maturation of WT K(v)11.1 levels was rescued by 10 muM d

245 The pH drop that accompanies endosomal maturation, often in conjunction with proteolysis, trigg

246 cAMP analogue Br-cAMP to mimic cAMP rise at maturation onset rescued meiotic maturation and spawning

247 life-history stages prioritising growth and maturation or body maintenance.

248 on 3' ends of nascent RNAs to promote their maturation or degradation but how the balance between th

249 ergy production, and hormone-mediated oocyte maturation pathways.

250 novel morphological cell clusters and axonal maturation patterns.

251 growth-phase factors and, thus, support the maturation phase of oogenesis.

252 e findings provide insight into the affinity maturation process and potential cross-reactivity of VH3

253 ation on germline Ab binding to ZIKV and the maturation process that gives rise to potently neutraliz

254 During an immune response, DCs undergo a maturation process that optimizes their ability to effic

255 d hepatocytes are the result of an intricate maturation process that starts with the formation of the

256 ich aspects take longer to refine during the maturation process.

257 unction, serve a role in the broader cardiac maturation program.

258 significance of genetic diversification for maturation programs, particularly in seed plants.

259 nsertion requires the action of over a dozen maturation proteins provided by the NIF (for NItrogen Fi

260 factor requires the activity of at least six maturation proteins, designated HypA-F.

261 During endosome maturation, Rab5 is replaced by Rab7, though the underly

262 tula (AVF) creation but fails to improve AVF maturation rates.

263 Genetic studies of seed maturation regulators, combining transcriptomics and net

264 y strategies in long-lived animals with slow maturation remain enigmatic.

265 tabolic pathways, including Okazaki fragment maturation, replication of 'difficult-to-replicate' DNA

266 hormone, ecdysteroid, coordinates growth and maturation, represented by molting and metamorphosis [2]

267 Moreover, CD63-mediated SG maturation requires type II phosphatidylinositol 4 kinas

268 link between prolidase activity and neuronal maturation shedding new light on the molecular basis of

269 r of adult-born dentate granule cell (abDGC) maturation so mapping the functional connectivity betwee

270 cardiac nerve development and cardiomyocyte maturation soon after birth.

271 s targeting postnatal periods of hippocampal maturation (specifically targeting periods of synaptic r

272 Therefore, cultivar and maturation stage factors should be take into account due

273 follicle cell differentiation into the final maturation stage, which leads to anovulation.

274 e results of our study justify the need of a maturation step and suggest promising routes to hinder v

275 ved low NK cell numbers and impaired NK cell maturation, suggesting that STAT5b is involved in termin

276 er and in poorer condition than fish showing maturation tactics, but were similar in size to unassign

277 uity in the protein interactions driving CCP maturation than anticipated.

278 time capsules reflecting different times of maturation that can be used to understand the glycosylat

279 ory to inhibitory is a key event in neuronal maturation that depends on the regulated expression of c

280 sed to determine the status of cardiomyocyte maturation, they could be time-consuming and often prese

281 squid Dosidicus gigas support growth during maturation through continuous feeding (an "income" sourc

282 omote myelin restoration and oligodendrocyte maturation throughout remyelination.

283 , decreases cDC1 apoptosis, and repairs cDC1 maturation to drive superior control of tumor outgrowth.

284 tional antibody reengineering (e.g. affinity maturation) to generate potential therapeutic candidates

285 alysis of in vivo and in vitro cardiomyocyte maturation trajectories identify highly conserved signal

286 opose that EXOSC10 promotes normal growth-to-maturation transition in mouse oocytes by sculpting the

287 s quantitative analyses of cytotoxic granule maturation, transport and fusion in vitro with super-res

288 n cell fate switch occurs during male sexual maturation under the cell-autonomous control of the sex-

289 Extracellular vesicle maturation was also defective in the vps27Delta mutant,

290 Early pubertal maturation was defined as reaching a certain pubertal st

291 Pericyte maturation was necessary to undergo vessel remodeling du

292 early in development to GluN2A-containing on maturation was similarly unperturbed despite the loss of

293 The impact of Q92R-Sec61alpha1 on neutrophil maturation was validated by using HL-60 cells, in which

294 single-domain antibody library and PCR-based maturation, we have produced two closely related nanobod

295 d since migration is important for thymocyte maturation, we investigated a role for WNK1 in mouse thy

296 ved in vertebrates and regulates erythrocyte maturation, where it becomes the most abundant miRNA.

297 These results suggest that all male-mediated maturation (whether accelerated, on-time, or delayed) ma

298 f AMPKalpha or PGC1alpha causes defective PC maturation, which could not be rescued by metformin.

299 ism has emerged as a potent means to control maturation with unexpected effects on electrical and mec

300 Such differential maturation would be well placed to play a role in regula