ライフサイエンスコーパス: maturational

1 thodology for characterizing and documenting maturational abnormalities in brain systems associated w

2 nfants exhibited significant global cortical maturational abnormalities, including reduced surface ar

3 The thymi of Sh2d3c(-/-) mice showed no maturational abnormalities, the number of splenic T cell

4 nt after mid-adolescence, suggesting reduced maturational achievement of the pursuit system in autism

5 nclude that MBT-1 specifically regulates the maturational advancement of myeloid progenitor cells dur

6 d of the first year of life was dependent on maturational age and not on the duration of exposure to

7 lopmental deficits are reflective of earlier maturational alterations occurring at the time of neurul

8 The trajectory of maturational and aging effects varied considerably over

9 yos exposed to high glucose exhibit aberrant maturational and cytoarchitectural cellular changes, imp

10 nown of the molecular mechanisms controlling maturational and experience-dependent refinement.

11 hting research that reveals the interplay of maturational and experiential influences at key juncture

12 rom the EGL to IGL that reflects cell cycle, maturational and migrational abnormalities.

13 t prominent features identified as potential maturational and outcome-sensitive biomarkers.

14 tion stimuli, rapidly differentiate into two maturational and phenotypically distinct populations.

15 ures and epileptogenesis are associated with maturational and seizure-induced changes in AMPA recepto

16 fter a comparable time period to control for maturational and test-retest effects.

17 of primary destructive disease and secondary maturational and trophic disturbances.

18 tter pathologies may follow a developmental, maturational, and/or degenerative process.

19 and the M. tuberculosis phagosome displays a maturational arrest at an early endosomal stage along th

20 t to originate from B-cell precursors with a maturational arrest at the pro-B cell stage and it is as

21 l atrophy of all lymphoid organs, owing to a maturational arrest before the pro-B/T cell stage.

22 -restricted overexpression of T-bet causes a maturational arrest in mononuclear phagocyte lineage cel

23 tion (Runx2 Delta C) do not form bone due to maturational arrest of osteoblasts.

24 al syndrome characterized by oligodendrocyte maturational arrest, interneuron loss, and spastic neuro

25 rkers and cytokine production but also has a maturational aspect that affects a cell's ability to sur

26 We constructed structural and maturational association matrices and networks from thes

27 Animal studies indicate that the maturational balance of excitatory and inhibitory neurot

28 These data suggest that this "maturational" betaH1- to epsilony-globin switch is dynam

29 ion with lysophosphatidic acid overcame this maturational block and induced closure of lesions, promo

30 duced numbers of B lymphocytes and display a maturational block in the development of mature B cells.

31 aratively little information about premorbid maturational brain abnormalities in schizophrenia (SCZ).

32 o generate enucleated erythrocytes after 3-4 maturational cell divisions.

33 apid eye movement (NREM) sleep is a dramatic maturational change in brain electrophysiology thought t

34 the induction rules for LTP, explained by a maturational change in GABAergic inhibition, and could h

35 creased GM1-lipid raft association through a maturational change of phospholipid composition on the c

36 luminal milieu and which itself may undergo maturational changes along the epididymis.

37 rall, we demonstrate failure of white matter maturational changes and progressive loss of white matte

38 Maturational changes at the CD4(-)CD8(-) double negative

39 n system; and (iv) podocytes undergo typical maturational changes but subsequently de-differentiate a

40 able developmental transitions, though brain maturational changes during this period are subtle and d

41 and is responsible for many of the prepartum maturational changes essential for neonatal survival.

42 been hypothetically related to synchronized maturational changes in anatomically connected neuronal

43 Unique maturational changes in brain structure, supported by in

44 ion of the brain which parallels substantial maturational changes in cognition and affect regulation.

45 To better characterize maturational changes in DNAm patterns in these cells, we

46 s is important because glucocorticoid-driven maturational changes in fetal cardiovascular function un

47 l trait behavior can be explained in part by maturational changes in frontal cortical and subcortical

48 development of mitral cells and arrested the maturational changes in membrane conductance and couplin

49 to induce at least one of the characteristic maturational changes in mouse bone marrow-derived DCs.

50 Overall, our studies identified maturational changes in neurons that likely contribute t

51 To identify maturational changes in neurons that may improve outcome

52 first evidence that it is the curvatures of maturational changes in neurophysiological oscillations

53 orted results demonstrating significant late maturational changes in the approximately 20 Hz common o

54 bservations are novel, and highlight how the maturational changes in the expression of these receptor

55 wn that this "waiting period" is governed by maturational changes in the limb.

56 inopathy of prematurity (ROP), with cortical maturational changes in VPT infants.

57 to adults, children demonstrated significant maturational changes including longer latencies and larg

58 migrate to draining lymph nodes and undergo maturational changes on exposure to reactive haptens.

59 h increasing age in children could be due to maturational changes or to proportionately smaller doses

60 ance of AMPAR-mediated EPSCs and the lack of maturational changes show that GABA depolarization acute

61 It is now recognized that extensive maturational changes take place in the human brain durin

62 ypic responses to environmental stimuli, and maturational changes that occur before and during the ad

63 The maturational changes that take place in the brain during

64 Thus, axons wait in the plexus region for maturational changes to occur in the limb rather than in

65 e responses to such earlier perturbations or maturational changes.

66 pharmacological agents that produced unique maturational changes.

67 ignaling through CXCR4, is implicated in the maturational chemotaxis of MKs toward sinusoidal vessels

68 at the nonpermissive temperature can undergo maturational cleavage and go on to form infectious virio

69 tion by innate immune receptor signaling and maturational cleavage by inflammasomes.

70 This maturational cleavage occurs between a histidine at posi

71 nase, PA-457 appears to block only the final maturational cleavage of p25CA-p2 to p24CA.

72 has a lesion in the protease responsible for maturational cleavage of the scaffolding protein, we hav

73 negative endosomes arise as a consequence of maturational conversion of EEA1/NEEP21 double-positive e

74 Evidence for sexually dimorphic maturational coupling was found within a frontopolar-cen

75 es showing the strongest and most widespread maturational coupling with other cortical areas, and low

76 erconnectivity showed significantly elevated maturational coupling.

77 s lower, whereas the rate of increase in its maturational cross-link, pyridinoline, was comparable wi

78 More complex maturational curves were also detected, with regions suc

79 ring also demonstrated an appropriate 4-fold maturational decline in luciferase expression in the sma

80 unexpected cell type specificity and a steep maturational decline of homeostatic plasticity.

81 trol since there was no change in the normal maturational decrease in FHR and rise in MAP.

82 lphabeta(-/-) mice exhibited signatures of a maturational defect including reduced growth, a late fet

83 e proteins FZD3 and CELSR1-3 revealed severe maturational defects without changing the identity of ne

84 BT-1(-/-) myeloid progenitor cells exhibit a maturational deficiency but maintain normal proliferativ

85 oxygenase) orthologs have been implicated in maturational degradation of intracellular organelles and

86 FTR-associated ligand (CAL) facilitates post-maturational degradation of the channel and is thus a po

87 Overall, this study shows that maturational delay in TNFR expression particularly by pr

88 layed development in SHR may be related to a maturational delay observed in children with ADHD.

89 bstrate delivery to lysosomes, autophagosome maturational delay, as further confirmed by our in vitro

90 atients with COS showed significantly longer maturational delays, with cortical thickness correlation

91 m that SWA is a highly sensitive tool to map maturational differences in experience-dependent plastic

92 to performance discrepancies; alternatively, maturational differences in functional neuroanatomy coul

93 These data demonstrate that there are maturational differences in lung NF-kappaB activation an

94 We determined whether maturational differences in lung NF-kappaB activation co

95 These findings suggest that maturational differences in subcortical and prefrontal r

96 rity with the motor task, GABA levels and/or maturational differences in the integrity of the white m

97 patients, may be influenced by regional and maturational differences in the ratio of M1 to M23 prote

98 The goal of this study was to examine maturational disturbances in CD4 T cell differentiation

99 appear to be related to widespread cellular maturational disturbances that target cerebral gray and

100 These findings also point to important maturational effects from 'early' to 'late' during task

101 milar patterns were observed, but with fewer maturational effects in some regions.

102 ver and kidney and may mediate, in part, the maturational effects of cortisol.

103 ations nearby, indicating the existence of a maturational escape process, possibly in adaptation to v

104 0 or 120 kDa NCAM isoforms in this important maturational event.

105 ll three of which are also required for this maturational event.

106 We propose a model by which these maturational events are controlled by the signal sequenc

107 ing for differences in longevity and various maturational events between the species (i.e., adjusted

108 include the induction of alterations in the maturational events of the endocannabinoid system occurr

109 cytokines are thought to induce a series of maturational events primarily by transcriptional regulat

110 nsistent with postmortem studies of cellular maturational events such as increased myelination and sy

111 ues in the activation loop and C terminus as maturational events that influence enzyme activity and t

112 itive selection there are time, spatial, and maturational events that occur before KLF2 is finally up

113 e somatic mutation, as well as class switch, maturational events that presumably require the particip

114 se results suggest that progressive cellular maturational events, such as increased myelination, may

115 s in children younger than 5 years depend on maturational factors in anatomy, gastrointestinal physio

116 to respond to prismatic deviation depends on maturational factors indicated by the onset of stereopsi

117 entially novel subcellular mechanism for the maturational failure of oligodendrocytes and offers a po

118 the molecular mechanisms for oligodendrocyte maturational failure remain unclear.

119 BDNF-TrkB signaling regulated the maturational formation of new branches in ON but not the

120 to TH throughout development and a specific maturational function around birth.

121 IV G-CSFR in AML uncouples proliferative and maturational G-CSFR signaling pathways.

122 tro from human embryonic stem cells undergo 'maturational' globin switching as they differentiate ter

123 This pattern of results suggests a maturational gradient within the medial temporal lobe me

124 be relatively preserved in TS owing to their maturational growth before or early in typical pubertal

125 useful to fill cartilage defects, while the maturational growth phenotype may be useful to induce ma

126 integrity, and subsequent incubation led to maturational growth with minimal changes in tissue volum

127 These findings suggest that the maturational histories of the striosomal and matrix neur

128 eased after postnatal day (P)10 because of a maturational increase in membrane conductance.

129 , both across development to coincide with a maturational increase in vesicle cycling and quantal amp

130 des of development were quantified using the maturational index (MI), estimated as Spearman's correla

131 The maturational influence on outcome was more strongly note

132 We found significant and specific maturational lag in connections within default mode netw

133 Furthermore, children with ADHD exhibited a maturational lag in development of posterior alpha power

134 Our finding of maturational lag specifically in connections within and

135 the gap in test scores could be explained by maturational lags in the frontal and temporal lobes.

136 Recognition of maturational lineage biology and its regulation by these

137 ple subpopulations with traits suggestive of maturational lineage stages and yet capable of self-repl

138 Intrahepatically, there are at least eight maturational lineage stages from the stem cells in zone

139 Livers are comprised of maturational lineages of cells beginning extrahepaticall

140 We find that dark rearing blocks both the maturational loss of ON-OFF responsive RGCs and the prun

141 Two of these, called the maturational (M) and release (R) sites, are conserved in

142 internal (I), cryptic (C), release (R), and maturational (M) sites and at a newly discovered "tail"

143 PD-1 expression was independent of maturational markers on memory CD8(+) T cells and was no

144 In vivo, the later steps include a maturational membrane penetration that is dependent on t

145 for PKCepsilon signaling in normal postnatal maturational myocardial development and suggest the pote

146 ation was somewhat predictable by structural/maturational networks but demonstrated a stronger bias t

147 Both structural and maturational networks shared similar global and nodal to

148 Consistent with the maturational onset of changes in 5-HT, striatal dopamine

149 frontal cortex during adolescence and in the maturational organization and adult plasticity of prefro

150 ies of this capacity develop along a regular maturational path, such that it seems more appropriate t

151 n the retinal periphery thus follow distinct maturational paths.

152 size-distinguishable morphs differ in their maturational pattern of TnT splicing, yet they show the

153 be used to improve the detection of deviant maturational patterns indicative of neurodevelopmental d

154 age 11-16.5 years is a critically important maturational period for the brain processes that underli

155 We identified three maturational phases in S-cell distributions.

156 calcium into enamel during the secretory and maturational phases of formation.

157 dritic cells (DCs) progress through distinct maturational phases; immature DCs capture Ag while matur

158 There is a dramatic difference in maturational phenotype between the two cell lines, howev

159 KCdelta autophosphorylation in the "priming" maturational PKCdelta-Thr(505) phosphorylation that acco

160 d the transcriptional events that drive this maturational process are not known.

161 This extratesticular maturational process is accompanied by the activation of

162 This maturational process is called capacitation and in mouse

163 This maturational process is thought to include the refinemen

164 This maturational process occurs in parallel with accumulatio

165 We have shown the maturational process of LV torsion in normal subjects.

166 period induced long-term disruption of this maturational process, such that even 1 year later animal

167 d human personality develop via an unfolding maturational process.

168 and that hydrocortisone can accelerate this maturational process.

169 and higher-precision fMRI data to find that maturational processes and cognitive ability track indiv

170 eural plasticity over and above normal brain maturational processes are discussed.

171 ical maturation or whether, instead, the two maturational processes are parallel but independent prog

172 Postnatal maturational processes convert bistratifying ON-OFF RGCs

173 Pathological states that interfere with such maturational processes could result in neurodevelopmenta

174 The amygdala undergoes maturational processes during adolescence, and therefore

175 s that is essential for gonadotropin-induced maturational processes in OCC.

176 Luteinizing hormone (LH) induces maturational processes in oocyte-cumulus cell complexes

177 arities of this conformational change to the maturational processes of more complex DNA viruses (e.g.

178 The contribution of local maturational processes of progenitors within the airways

179 eriences might play a critical role in these maturational processes, animals were raised in the absen

180 While many factors are involved in these maturational processes, studies of cell proliferation an

181 rvention, yet potentially jeopardizes normal maturational processes.

182 on alone is not sufficient to initiate these maturational processes.

183 tulated that thyroid hormone regulates these maturational processes.

184 ay have detrimental consequences and disrupt maturational processes.

185 RNA precursors (pre-mRNAs) undergo extensive maturational processing, including cleavage and polyaden

186 Thus, the absence of CasR alters neither the maturational profile of isolated osteoblast cultures nor

187 CD4 T cells with specific developmental and maturational profiles are able to effectively support HI

188 It is unknown whether alterations in ICN maturational profiles can reliably detect impaired atten

189 ny perceptual theories that posit particular maturational profiles in higher-order (i.e., cortical) m

190 We discuss the meaning of these maturational profiles in terms of time course of morphol

191 ikely to be indicative of an overall retinal maturational program in which cell differentiation and t

192 lasticity is regulated by the execution of a maturational program intrinsic to inhibitory neurons.

193 he internal scaffold protein, BdRF1; and the maturational protease (BVRF2).

194 We compared the full-length capsid maturational protease (pPR, pUL80a) of human cytomegalov

195 with an HSV-1 mutant (m100) deficient in the maturational protease for which it was expected that pro

196 bly protein precursor (pAP, pUL80.5) and the maturational protease precursor (pPR, pUL80a), contain t

197 ute to this scaffolding function; one is the maturational protease precursor (pUL80a), and the other

198 of a temperature-sensitive lesion in the HSV maturational protease UL26.

199 shell, the UL26.5 product together with the maturational protease, a minor protein, form a spherical

200 The cytomegalovirus (CMV) maturational protease, assemblin, contains an "internal"

201 ffect capsid assembly, activity of the HSV-1 maturational protease, or formation of DNA-containing ca

202 capsid protein, and may slow cleavage by the maturational protease.

203 l-lethal mutant of the cytomegalovirus (CMV) maturational protease.

204 e that may correspond to the location of the maturational protease.

205 rvation in their DNA packaging machinery and maturational proteases.

206 The human cytomegalovirus (HCMV) maturational proteinase is synthesized as an enzymatical

207 This protein, and the genetically related maturational proteinase, is distinguished from the other

208 For these latter proteins, maturational proteolysis by the adenoviral protease lead

209 of Lp82 in the lens may be to retard normal maturational proteolysis.

210 , viral late protein synthesis occurred, but maturational proteolytic processing was inhibited, and t

211 blish that Cav1.2(KO) OPCs display a reduced maturational rate through the entire remyelination proce

212 Significant maturational rates of increasing fractional anisotropy (

213 ter layer of the Gag shell, (ii) directs the maturational rearrangements of the NTDs that yield a fun

214 Therefore we propose the function of the maturational refolding of the beta-hairpin in CA assembl

215 ce of Gag binding to CyP A was to block this maturational refolding, resulting in a 24-kDa CA protein

216 nal region in mature CA is also a product of maturational refolding.

217 n rat and human in the regional and temporal maturational regulation of neuronal and glial AMPAR expr

218 ue to the afferent neurons that arrest their maturational replacement by MyHCs associated with faster

219 In PSD-95/PSD-93 double-KO mice, the maturational replacement of NR2B- with NR2A-NMDARs fails

220 the effect of 17-beta-estradiol (E2) on the maturational response triggered by virus in human DCs an

221 effects of PLSCR1 on cell proliferative and maturational responses may also relate to alterations in

222 erences in antigen-TCR avidity encode unique maturational responses of lymphocytes and the influence

223 d that light stimulation is required for the maturational segregation of retinal ganglion cell (RGC)

224 This study shows that the maturational sequence for new neurons in the adult monke

225 lysis revealed ASD-associated changes in the maturational sequence of early neuron development, invol

226 Herpesviruses encode an essential, maturational serine protease whose catalytic domain, ass

227 crucial long-term roles in the assembly and maturational shaping of the same networks as they develo

228 These data imply that the maturational shift away from ADP-mediated respiratory co

229 with other brain systems are related to the maturational shift in behavior.

230 neonate, but does for the adult, indicates a maturational shift in the requirements for the developme

231 igate the factors that may contribute to the maturational shift of If, comparing neonatal rat ventric

232 g factor receptor (G-CSFR) proliferative and maturational signaling pathways are uncoupled.

233 in AML can uncouple G-CSFR proliferative and maturational signaling pathways.

234 (lck) constitutes an early step in conveying maturational signals after TCR ligation by a positively

235 duction of Ag presentation once APCs receive maturational signals.

236 Our results provide new evidence for maturational specialization of the striatal DA system th

237 We demonstrate that the next maturational stage after proT1 cells (proT2), but not pr

238 simply appear in SC neurons at a prescribed maturational stage but rather develops only after substa

239 e affinity/avidity of the TCR ligand and the maturational stage of the T cell are thought to be princ

240 that KIR acquisition remains dynamic at the maturational stage represented by the NK92 cell line.

241 ch the cortical slice is taken at an earlier maturational stage, one that corresponds to a time when

242 neage-selective determinants, in a cell- and maturational stage-specific context, has not yet been de

243 and mature DCs probably contribute to the DC maturational stage-specific glucocorticoid sensitivity.

244 bias already as thymocytes, at an HSA(high) maturational stage.

245 senchyme than r2 NCCs, irrespective of their maturational stage.

246 ng pathways have distinct roles according to maturational stage.

247 ions of hematopoietic precursors at multiple maturational stages and substantiate the previously unre

248 omposition of lysosomal MIIC at different DC maturational stages appear important for surface egressi

249 these data help to validate specific rodent maturational stages as appropriate models for evaluation

250 the dendrites of adult-born GCs at the early maturational stages depended on the activation of NMDA r

251 Isolation of cells at defined maturational stages has enhanced the understanding of th

252 distinct, progressively more differentiated maturational stages of CD4 memory subpopulations in heal

253 Thus, by using both CCR7 and CD27, distinct maturational stages of CD4 memory T cells with different

254 At E11.5, we observe all maturational stages of erythroid precursors in the liver

255 stress in the liver and lungs, affected the maturational stages of hematopoietic stem cells, reduced

256 Developing neurons undergo a series of maturational stages, and the timing of these events is c

257 At specific maturational stages, neural circuits enter sensitive per

258 nd of brain dynamics in relation to regional maturational stages, promise to yield a better understan

259 -born granule cells (GCs) at their different maturational stages, the mechanisms controlling the inte

260 ls generate thymocytes representative of all maturational stages.

261 age transition from the pre-pro-B to further maturational stages.

262 thus serve as markers for distinct proT cell maturational stages.

263 l dendrites of adult-born GCs at their early maturational stages.

264 ult-born GCs during their early but not late maturational stages.

265 Cell size, maturational state (as measured by the proportion of bin

266 nitively that ORs are expressed prior to the maturational state defined by OMP expression.

267 Thus, ventricular maturational state influences the voltage dependence of

268 to antigen presentation is dependent on the maturational state of dendritic cells (DCs), we hypothes

269 ch progressively change in parallel with the maturational state of the cortex.

270 we found that the PMA effect depended on the maturational state of the synapses.

271 ts on hematopoietic cells depending on their maturational state, preventing and/or delaying the diffe

272 hout an effect on their synaptic strength or maturational state.

273 e an empirical basis to recognize equivalent maturational states across animals.

274 function acting in a manner dependent on the maturational states of neuronal networks.

275 The KC number, functional activity, and maturational status are directly related to the concentr

276 Previously, the maturational status of CD8alpha-(myeloid) DCs has been s

277 ition to alteration in T cell responses, the maturational status of dendritic cells in lymph nodes wa

278 DNA methylation profile, preserved from the maturational status of the original cell.

279 hibition of DC maturity that is resistant to maturational stimuli and modulates antigen-specific immu

280 en 2 and 3 weeks after birth coincident with maturational stress.

281 ts the theta age curve parallels the earlier maturational thinning in 3-layer cortex, whereas the del

282 However, maturational timing in female mammals can also respond t

283 male life history characteristics, including maturational timing, reproductive hormones, adult size,

284 relatedness with clusters that have similar maturational timing.

285 te therapeutic target for correction of post-maturational trafficking defects in cystic fibrosis.

286 G patterns, cementing the link between early maturational trajectories and neurodevelopmental outcome

287 ficits in cortical thickness and areas whose maturational trajectories are altered in schizophrenia.

288 We defined maturational trajectories between the Electroencephalogr

289 es composed of cortical regions with similar maturational trajectories for cortical thickness in typi

290 The maturational trajectories of cognitive and brain develop

291 pants' patterns of deviations from normative maturational trajectories were indicative of sustained a

292 ducible subpopulations representing distinct maturational trajectories, stages and subtypes, includin

293 ling in the postnatal cortex controlling the maturational trajectory across modalities.

294 tive hypothesis that these insults alter the maturational trajectory of SPNs.

295 ently delineated in 6-month-old infants, the maturational trajectory of these mechanisms remained unc

296 ed memories for experiences have a prolonged maturational trajectory.

297 Synaptic contacts undergo a maturational transformation from multiple small to one s

298 posure of deprived mice to light confirmed a maturational transition regardless of visual input.

299 ropriately formed immature particles and the maturational transitions that create a functional virion

300 between -1253 and -1180 bp are necessary for maturational up-regulation of NR2A.