ライフサイエンスコーパス: mechanical force

1 ckly at room temperature after unmasking via mechanical force.

2 myocytes, its activity could be regulated by mechanical force.

3 iezos are ion channels that are activated by mechanical force.

4 sponse of the mechanotransduction channel to mechanical force.

5 ty of stimuli including heat, light, pH, and mechanical force.

6 e required to insulate genetic material from mechanical force.

7 late how strongly sensory neurons respond to mechanical force.

8 tures that adapt their growth in response to mechanical force.

9 further how Piezo channels are regulated by mechanical force.

10 roposed mechanisms, enzymatic liberation and mechanical force.

11 Cells continuously exert or respond to mechanical force.

12 sically active structure capable of exerting mechanical force.

13 ll has long been considered to be subject to mechanical force.

14 by extension the LINC complex, is subject to mechanical force.

15 e also define the response of the protein to mechanical force.

16 nvade, either via proteolytic degradation or mechanical force.

17 ological processes that require sensation of mechanical force.

18 an alter how a lattice deforms under applied mechanical force.

19 e molecular mechanisms of how channels sense mechanical force.

20 ion and 3D shape, as well as bending-related mechanical force.

21 irectly bind F-actin only in the presence of mechanical force.

22 ities, few studies have examined the role of mechanical forces.

23 ells are constantly exposed to pathogens and mechanical forces.

24 ered new biological effects of blink-induced mechanical forces.

25 sive cut unit cells to be reconfigured under mechanical forces.

26 develop, they are subjected to a variety of mechanical forces.

27 ponse to external stimuli such as sounds and mechanical forces.

28 inearization independently of cell-generated mechanical forces.

29 w that mitochondrial fission is triggered by mechanical forces.

30 ing area and that this behavior depends upon mechanical forces.

31 ling of the adherens junction in response to mechanical forces.

32 implantable pulse generator dysfunction, and mechanical forces.

33 plastic substrates can generate substantial mechanical forces.

34 interfering with the exploitation of passive mechanical forces.

35 ogical and structural changes in response to mechanical forces.

36 l known that it releases 5-HT in response to mechanical forces.

37 niche through secreting factors and exerting mechanical forces.

38 , suggesting local network reorganization by mechanical forces.

39 cell releases this serotonin in response to mechanical forces.

40 light the interplay between each pathway and mechanical forces.

41 n increase in the strength and anisotropy of mechanical forces.

42 namic reorganization of cells in response to mechanical forces.

43 el the influence of seawater temperature and mechanical forces.

44 gating the coupling of cellular dynamics and mechanical forces.

45 eric phosphatase exclusion as well as direct mechanical forces.

46 by a sequence of multiple factors including mechanical forces.

47 ss that extends axons via the application of mechanical forces.

48 cytokinetic ring to both generate and sense mechanical forces.

49 aptors, microtubule-associated proteins, and mechanical forces.

50 ding tissues by the action of biofilm and/or mechanical forces, a process termed metallosis, can be r

51 They transmit mechanical force across the NE in processes such as nucl

52 A variety of mechanical forces act on these complexes in the cartilag

53 In a more general framework, mechanical forces acting on a molecular system can stron

54 Here we show that when people judge the mechanical forces acting on an object, their judgments a

55 shaped by growth, detachment and response to mechanical forces acting on them.

56 Low-threshold mechanical forces activate corneal receptors evoking dis

57 n associated with plant growth hormones, how mechanical forces actuate the process is still unknown.

58 Given that mechanical forces affect neuronal outgrowth, it is impor

59 tudied in vitro(2,3), it remains unclear how mechanical forces affect their behaviour in vivo.

60 l for OFT valve morphogenesis in response to mechanical forces, albeit active in different cell layer

61 its backbone integrity, and delivering high mechanical forces alone by ultrasonication degrades the

62 ts that a stretch of the membrane induced by mechanical force alters the physical state of the lipid

63 ons such as high temperatures, pressures and mechanical force, among others.

64 ion of rocks due to elevated climate-related mechanical forces (an increasing frequency of days with

65 isions and is distinctive in its reliance on mechanical force and protein glycosylation.

66 Mechanical force and Wnt signaling activate beta-catenin

67 Cell nuclei rupture following exposure to mechanical force and/or upon weakening of nuclear integr

68 lular matrix (ECM) components that can exert mechanical forces and affect nuclear structure.

69 s, synovial fibroblasts exposed to anomalous mechanical forces and an inflammatory microenvironment r

70 uctural properties, particularly by exerting mechanical forces and by serving as a scaffold for bindi

71 -oscillating mechanical motion that produces mechanical forces and deformations in adjacent materials

72 perform Boolean computations based purely on mechanical forces and displacements with no electronic c

73 for hemidesmosomes as regulators of cellular mechanical forces and establish the existence of a mecha

74 role of cytoskeletal effectors that mediate mechanical forces and morphological changes essential fo

75 ified critical molecular events initiated by mechanical forces and potential therapeutic targets for

76 acromolecular assemblies which help transmit mechanical forces and regulatory signals between the ext

77 ic field as well as the energy requirements, mechanical forces and stresses during switching of the p

78 directional interplay between cell-generated mechanical forces and the activity of Rho GTPases, a fam

79 sue deformation leading to the generation of mechanical forces and the deformation of the organ in th

80 the ability of the cell's machinery to sense mechanical forces and tune the force-generating machiner

81 anding how such tissues sense and respond to mechanical force, and the anatomical extent of several m

82 Mechanical force applied on ICAM-1 impairs CD2AP binding

83 Our analysis explains how mechanical force applied to alphaE-catenin or its homolo

84 these defects move merely to comply with the mechanical forces applied on macroscopic scales, whereas

85 ellular mechanosensation, a process by which mechanical forces applied on the cell membrane are conve

86 ofilm initiation, but it remains unclear how mechanical forces applied to a bacterium are translated

87 Mechanical forces are critical but poorly understood inp

88 In the eye cornea, comparatively low mechanical forces are detected by polymodal and pure mec

89 findings in the past few years showing that mechanical forces are directly transmitted into the nucl

90 g evidence in eukaryotic cells suggests that mechanical forces are essential for building a robust mi

91 e generated transformative hypotheses on how mechanical forces are generated and sensed in biological

92 which endeavours, broadly, to understand how mechanical forces are harnessed to drive cellular functi

93 Mechanical forces are important in the regulation of phy

94 Mechanical forces are increasingly recognized to regulat

95 Mechanical forces are integral to cellular migration, di

96 Mechanical forces are integral to development-from the e

97 Mechanical forces are integral to many biological proces

98 r scales, it is increasingly recognized that mechanical forces are involved in the modulation of size

99 Mechanical forces are key regulators of cell and tissue

100 As cell-generated mechanical forces are known to be critical to the matrix

101 Mechanical forces are known to play a major role in plan

102 As these extremely low mechanical forces are physiologically relevant, stretch-

103 Mechanical forces are projected onto the channels by mol

104 We find that localized mechanical forces are sufficient to induce the formation

105 trol gene expression, it remains unclear how mechanical forces are transduced through the nucleus.

106 Rationale: Mechanical forces are transduced to nuclear responses vi

107 Mechanical forces are well known for modulating heart va

108 Due to various technical limitations, mechanical force as a stimulus in the context of polymer

109 a mechanical barrier that can be overcome by mechanical force as well as disruption of the cytoskelet

110 ese neurons are very long and exposed to the mechanical forces associated with limb movement; most la

111 machine vision, we estimated whisker-object mechanical forces at millisecond resolution.

112 orming the antipolyelectrolyte effect into a mechanical force based on the salinity gradient.

113 Among them, the emerging mechanical force-based stimulus offers a convenient and

114 Mechanical forces between cells and their extracellular

115 Cell-cell junctions respond to mechanical forces by changing their organization and fun

116 l neurons and contributes to transduction of mechanical forces by corneal nociceptors.SIGNIFICANCE ST

117 adhesion complexes that sense and propagate mechanical forces by coupling cadherins to the actin cyt

118 first examine the detection and encoding of mechanical forces by primary mechanoreceptor neurons.

119 are essential for transduction of innocuous mechanical forces by proprioceptors and cutaneous touch

120 The work reveals that a mechanical force can shift the redox potential of a mole

121 ition to locally acting signals, tissue-wide mechanical forces can act as organizing cues, and that t

122 While it is well known that mechanical forces can affect tissue morphogenesis and pa

123 Mechanical forces can be generated when nascent protein

124 These findings demonstrate that mechanical forces can inhibit the function of cell envel

125 Mechanical forces can strengthen (catch) or weaken (slip

126 cell shape, driven by gene expression and/or mechanical forces, can promote breast cancer progression

127 oth intrinsic and extrinsic signals, such as mechanical force, cell-cell contact, polarity, energy st

128 Here we show that an interplay between mechanical forces, cell migration and proliferation allo

129 by phosphate release from Arp2/3 complex and mechanical forces contribute to disassembling "old" acti

130 Mechanical forces contribute to portal hypertension (PHT

131 uire Piezo1 at the steady state, the type of mechanical force controls the outcome: stretch induces c

132 ation, while coupling of thermal effects and mechanical forces controls the stability of the clusters

133 mechanism of cell migration whereby cellular mechanical forces dissociate extracellular matrix (ECM)

134 ally thought to limit the electric-field- or mechanical-force-driven responses to the local scale.

135 ward since it is now possible to measure the mechanical forces due to whisker-object contact during b

136 physiological processes.Proteins fold under mechanical force during co-translational folding at the

137 ed by Arp2/3 complex generate and experience mechanical forces during essential cellular functions, i

138 nisms, tissues architectures are sculpted by mechanical forces during morphogenesis(2).

139 Cell-cell and cell-matrix junctions transmit mechanical forces during tissue morphogenesis and homeos

140 We conclude that polymerized actin provides mechanical force essential for all kinetically distingui

141 compression device that simulates the solid mechanical forces exerted by a growing tumor on the surr

142 ay between their material properties and the mechanical forces exerted on them.

143 Our findings suggest that mechanical forces-exerted from above and below progenito

144 that nodal alphaII spectrin helps resist the mechanical forces experienced by large-diameter axons, a

145 ical ventilation and the resultant excessive mechanical forces experienced by lung vascular endotheli

146 For folded Spy0125 without mechanical force exposure, thioester cleavage was in equ

147 n and resort to enzymatic liberation only if mechanical forces fail to retrieve antigen.

148 of the oxygen vacancy distribution using the mechanical force from a scanning probe microscope tip.

149 Our results indicate that mechanical forces from a tissue expander induce broad mo

150 Endothelial cells transduce mechanical forces from blood flow into intracellular sig

151 ical structure that mediates the transfer of mechanical forces from the cytoskeleton onto the nucleus

152 ined with diffusion on the cell membrane and mechanical forces generated in the cortex, can determine

153 However, bacteria must contend with mechanical forces generated through contact with surface

154 of cytoskeletal protein filaments is key for mechanical force generation driving animal tissue morpho

155 Current methods for examining mechanical force generation either necessitate dedicated

156 nent of seed germination is the interplay of mechanical forces governing embryo growth and the surrou

157 Although mechanical forces have been characterized at the single

158 g bLVR are related to microscopic changes in mechanical force heterogeneity; and (3) both techniques

159 actively respond to external stimuli-such as mechanical forces, hydration and magnetic fields-by chan

160 h model of cell adhesion, regulated by local mechanical forces, I show that cellular traction forces

161 9;3:230-245), the biological consequences of mechanical forces imparted by a growing tumor mass are e

162 ime of FcgammaRIIA-IgG bonds increased under mechanical force in an F-actin-dependent manner, which c

163 Proteins fold under mechanical forces in a number of biological processes, r

164 al important developmental processes involve mechanical forces in an essential manner.

165 We hypothesized that mechanical forces in bacterial adhesion could regulate t

166 Despite the vital role of mechanical forces in biology, it still remains a challen

167 receptor-ligand complexes and development of mechanical forces in cells.

168 The EMBO/EMBL Symposium 'Mechanical Forces in Development' was held in Heidelberg

169 rs seeking to address the origin and role of mechanical forces in development.

170 The importance of mechanical forces in influencing cell behaviour is widel

171 to enable the measurement of cell-generated mechanical forces in intact tissues in vivo, which will

172 in macrophage cells and for measurements of mechanical forces in multicellular spheroids and zebrafi

173 g which biological processes are affected by mechanical forces in TE is important for the development

174 new molecular-level insight into the role of mechanical forces in the assembly and function of GAG-ri

175 Mechanical forces in the cell's natural environment have

176 enges associated with accurately quantifying mechanical forces in the developing heart.

177 To determine the contribution of mechanical forces in the functional response of human sm

178 Blood flow and mechanical forces in the ventricle are implicated in car

179 tle knowledge on potential risks of applying mechanical forces in the vicinity of tumors.

180 ges in their implementation arising from the mechanical forces in the weaving process, evaporation of

181 agents to assess which polysaccharides bear mechanical forces in-plane and out-of-plane of the cell

182 nvelope efflux complexes may be sensitive to mechanical forces including complexes involved in antibi

183 Axons must withstand mechanical forces, including tension, torsion, and compr

184 clampsia symptoms at late-stage pregnancy as mechanical forces increase with fetal mass.

185 as a powerful tool to monitor the extent of mechanical force-induced cartilage injury in vivo.

186 Here, we report mechanical-force-induced large-area, non-local, collecti

187 onal assays to collectively demonstrate that mechanical force induces conformational changes in pMHCs

188 Understanding how mechanical forces influence morphogenesis at the cellula

189 Mechanical forces influence the development and behavior

190 Considerably less is known about how mechanical forces influence the disassembly of actin fil

191 The mechanism of translating mechanical force into a biochemical signal is not unders

192 tecture underscores the basis of translating mechanical force into an electrical signal within a cell

193 moderate cold potentiates the conversion of mechanical force into excitatory current in all types of

194 o develop synthetic materials that transduce mechanical force into multifold changes in their intrins

195 The translation of mechanical forces into biochemical signals plays a centr

196 tion involves the sensing and translation of mechanical forces into biochemical signals, like activat

197 n has an important role in the conversion of mechanical forces into biochemical signals.

198 d Piezo2 channels transduce various forms of mechanical forces into cellular signals that play vital

199 nt signalling as a candidate for transducing mechanical forces into joint cell behaviours.

200 autophagy are involved in the translation of mechanical forces into metabolic adaptation.

201 neurons play an important role in converting mechanical forces into the sense of touch.

202 To understand the mechanical forces involved in cell adhesion, molecular f

203 Mechanical force is a determinant of Notch signalling bu

204 irs in the hydrophobic leaflet separate when mechanical force is applied, exposing their hydrogen bon

205 Mechanical force is needed to mediate endocytosis.

206 Mechanical force is not only a relevant quantity in cell

207 atosensory neurons transduce acutely painful mechanical forces is largely unknown and remains one of

208 t the level of individual cells, the role of mechanical forces is well recognized in eukaryotic physi

209 losteric effects, chemical reagents, pH, and mechanical force, it is still challenging to introduce m

210 by testing the hypothesis that CAF-generated mechanical forces lead to activin A release and associat

211 ously reported that physiologically relevant mechanical forces lead to small repairable membrane inju

212 nd an antigen-presenting cell, implying that mechanical forces may apply to the bonds.

213 ng translation of viral RNA, indicating that mechanical forces may play a broader regulatory role in

214 Soft and flexible surfaces promote mechanical force-mediated antigen extraction, whereas st

215 chments is unknown, and the possibility that mechanical force might regulate centrosome function has

216 It has long been appreciated that mechanical forces must be applied to chromosomes.

217 er model does not expose epithelial cells to mechanical forces normally present in the intestine, inc

218 ry proteins of the thin filament require the mechanical force of cycling myosin to achieve the transi

219 f junction dynamics, actin organization, and mechanical forces of control and knockdown cells for myo

220 Furthermore, by modulating the mechanical forces of the microenvironment, we find that

221 ional technique that simulates the effect of mechanical force on a molecule and enables the predictio

222 onally been employed to study the effects of mechanical force on chemical bonds within a polymer back

223 lar junctions by which cells sense and exert mechanical force on each other.

224 ent studies have highlighted the presence of mechanical force on several immunoreceptor-ligand pairs

225 However, the impact of mechanical forces on infections leading to diarrheal dis

226 ace nanopatterns exert the necessary physico-mechanical forces on the bacterial cell membrane that wi

227 To test whether mechanical forces on the cell nucleus are relevant to NM

228 In turn, these local cellular changes create mechanical forces on the plant tissue that are balanced

229 Cells are physical objects that exert mechanical forces on their surroundings as they migrate

230 less of whether the motion was produced by a mechanical force or a solvent flow.

231 tric field and restored by applying either a mechanical force or an electric field of higher voltage.

232 deformation of the lipid bilayer, either by mechanical force or curvature, can induce integrin activ

233 nsory receptors of the inner ear, respond to mechanical forces originating from sounds and accelerati

234 e adaptive changes of bones and ligaments to mechanical forces, our understanding of how tissues actu

235 ntail epithelial cell size changes driven by mechanical forces; our work highlights how, in turn, mec

236 swell very rapidly and to withstand gastric mechanical forces over time.

237 Besides mechanical forces, Piezo1 is selectively activated by mi

238 Mechanical forces play critical roles in collective cell

239 These mechanical forces play crucial roles in regulating cell

240 fashion by changing the concentration or the mechanical force (pressure) applied.

241 In support of this model, mechanical force production is compromised and cell prol

242 ontrol of pMLC levels, which is critical for mechanical force production, likely through the direct i

243 axons of corneal neurons responding only to mechanical force (pure mechano-nociceptor) or also exhib

244 Mechanical forces regulate a large variety of cellular f

245 The use of mechanical forces renders antigen extraction sensitive t

246 te at gastrulation, but how the adhesive and mechanical forces required for these movements are gener

247 the actomyosin cytoskeleton in providing the mechanical forces required to remodel the lipid bilayer

248 Activation of Piezo2 by mechanical forces results in a characteristic ionic curr

249 Unanticipated roles of mechanical force sensing continue to be uncovered.

250 ications for understanding the mechanisms of mechanical force sensing.

251 consistent with heightened activity of this mechanical force-sensitive system in atherosclerosis.

252 Mechanical forces shape cells and tissues during develop

253 Mechanical force strengthens TCR-pMHC interactions to el

254 This has been attributed to mechanical forces, such as urine flow, that prevent the

255 he TIM-4-PS interaction is more resistant to mechanical force than the TIM-1-PS interaction.

256 A central source of stress is mechanical force that acts on cells, their nuclei, and c

257 dent strain then results in a time-dependent mechanical force that actuates microwire motion.

258 ntain its continuity in the face of external mechanical forces that accompany normal physiological fu

259 dheres to a surface from the bulk fluid, the mechanical forces that act on it change.

260 otein domain with its synthesis can generate mechanical forces that act on the ribosome and alter tra

261 odulation is dependent on the fine-tuning of mechanical forces that are transmitted in part through t

262 Tissue morphogenesis is driven by mechanical forces that elicit changes in cell size, shap

263 biochemical signaling interactions with the mechanical forces that eventually pattern and shape the

264 each anther locule, and desiccation creates mechanical forces that open the locules.

265 When subjected to mechanical force, the cadherin*catenin complex can tight

266 of a cell's ability to sense and respond to mechanical force, the molecular mechanisms by which phys

267 ation of the mechanosensors and the kinds of mechanical forces they can sense and respond to.

268 at SecA generates at least 10 piconewtons of mechanical force to actively unfold translocating protei

269 is contraction converts chemical energy into mechanical force to drive the iron-tipped tube across th

270 dies have revealed how Piezo1 protein senses mechanical force to enable vascular development.

271 Polymerized actin provides mechanical force to form endocytic pits.

272 Whether SecA generates mechanical force to overcome barriers to translocation p

273 with 40% of molecules requiring virtually no mechanical force to unfold (<10 piconewtons (pN)), sugge

274 t dramatic bond rearrangement in response to mechanical force to yield semiconducting polyacetylene.

275 using one whisker and enables task-relevant mechanical forces to be precisely estimated.

276 ave a narrow pore and therefore must capture mechanical forces to control gating in another way.

277 The application of mechanical forces to cultured cells is often performed u

278 ughput platform for applying complex dynamic mechanical forces to cultured cells.

279 aking advantage of the microarchitecture and mechanical forces to efficiently invade the intestine.

280 Tissue expansion procedures (TE) utilize mechanical forces to induce skin growth and regeneration

281 is driven by the increase and clustering of mechanical forces to push the centrosome toward the cell

282 rgy contained in ATP molecules into powerful mechanical forces to remodel a vast array of cellular su

283 Generating the mechanical forces to support motility are divergent clas

284 play an integral role in the transmission of mechanical forces to the central foveal cones.

285 d respond to intercellular and intracellular mechanical forces to transduce mechanical signals and ma

286 by the hot bubbles and mechanically by fluid mechanical forces to transiently increase cell membrane

287 n has been proposed to help axons resist the mechanical forces to which they are exposed (e.g., compr

288 In polymer mechanochemistry, a mechanical force, transduced along polymer chains, is us

289 response to membrane tension as a result of mechanical force transmitted directly to the channel fro

290 interactome is a molecular basis of sensing mechanical force transmitted via the lipid bilayer.

291 le proteins, kept unfolded and extended by a mechanical force, undergo accelerated ageing in times sc

292 vidual ScPif1 molecules on ssDNA extended by mechanical force, we identified two distinct types of ss

293 te how migrating cells detect and respond to mechanical forces, we used a "cell squasher" to apply un

294 e rotating magnetic field, creating a strong mechanical force which damages the cancer cell structure

295 (BPV)-induced cycle-by-cycle fluctuations in mechanical forces which vary considerably with pathology

296 ieved to involve coupled output and input of mechanical forces, which may constitute the key sensing

297 approaches due to the challenge of applying mechanical forces while monitoring structure and activit

298 r investigations of the application of these mechanical forces will provide insights into physiology

299 Mechanical force, with its ability to distort, bend, and

300 omoting disassembly of this protein complex, mechanical forces within the cell envelope make the bact