ライフサイエンスコーパス: mechanism by which

1 ardiovascular pathophysiology, and provide a mechanism by which a single receptor can exhibit a binar

2 Here, we examine the mechanisms by which a cargo-bound inner coat layer recru

3 sociated with nutrient availability, but the mechanisms by which a cell responds to fluctuations in a

4 These data provide insight into the mechanisms by which a common gut bacterium processes an

5 Here, we investigated the mechanisms by which a destabilizing HA mutation, Y17H (a

6 Today, the mechanisms by which AA is reduced during roasting remain

7 However, the mechanisms by which Abeta affects sleep are unknown.

8 ction leading to neuronal damage, underlying mechanisms by which Abeta modulates Cx43 in astrocytes r

9 However, the molecular mechanisms by which activation of defence reduces growth

10 arc of inquiry from neuronal to neuron-glial mechanisms by which activity and experience modulate cir

11 ctate dehydrogenase A (LDHA), establishing a mechanism by which AHR regulates lactate and UMP product

12 These findings identify a novel mechanism by which alcohol induces TGFbeta1 in the lung.

13 ssion of the fusion kinase NPM1-ALK, but the mechanism by which ALK overactivity drives toxicity upon

14 cause familial hemiplegic migraine, but the mechanisms by which alpha2-Na/K ATPase mutations lead to

15 The underlying mechanism by which alphakap is maintained and regulated

16 d the role of vesicular SOCS3 secretion as a mechanism by which AMs restrain allergic inflammatory re

17 Our results uncover a mechanism by which an enteric pathogen subverts repair p

18 The exact mechanism by which an environmental stimulus to skin res

19 ties of the microbiota in children with JIA; mechanisms by which an altered microbiota at birth and l

20 These data provide direct mechanisms by which an MHC-II SE contributes to expressi

21 This represents a possible mechanism by which animals identify and remember locatio

22 The molecular mechanisms by which animals integrate external stimuli w

23 Collectively, our study uncovered a novel mechanism by which AtPRMT3 cooperates with RPS2B to faci

24 The mechanism by which ATR signals that its cofactor cargo i

25 This work provides a novel and more general mechanism by which attention interacts with choice.

26 These findings define a novel mechanism by which autophagy regulates neuronal activity

27 The study results reveal a novel mechanism by which bacteria alter mood.

28 By understanding the mechanisms by which bacteria promote animal metamorphosi

29 se findings advance our understanding of the mechanisms by which bacterial nucleic acids traffic extr

30 To begin to understand the mechanism by which beta-arr1 together with STAM1 activat

31 Our findings also uncover a new pathogenic mechanism by which beta-catenin promotes podocyte injury

32 Despite much work, the mechanisms by which bnAbs emerge remain uncertain.

33 e discuss recent advances in elucidating the mechanisms by which BRCA1-BARD1 functions in DNA repair,

34 Taken together, these results reveal a mechanism by which BRD4 inhibition suppresses tumor grow

35 nificantly less attention and the underlying mechanisms by which cations interact with macromolecules

36 Investigation of the mechanism by which CD82 promotes AML survival in respons

37 NANP composition can dictate the degree and mechanisms by which cell immune responses are initiated.

38 valent cations are likely to be an important mechanism by which cells can control their cytoplasmic m

39 Ultimately, apoptosis is an important innate mechanism by which cells counter viruses at local sites

40 This work describes a simple biophysical mechanism by which cellular proteostasis adapts to meet

41 The mineralization mechanism by which cellulosic, keratinous, and silk tiss

42 The mechanisms by which certain ART agents differentially co

43 It also points to a mechanism by which changes in flowering phenology can af

44 The mechanism by which changes in O(2) tension modulate ion

45 able experimental data, reveal processes and mechanisms by which chemical species (cations, peptides,

46 Elucidating the mechanisms by which CHIKV subverts antiviral immunity to

47 erol; this identified a potential allosteric mechanism by which cholesterol binding regulates the con

48 he sera and liver of cachectic, suggesting a mechanism by which chronic IL-1R signaling could be lead

49 Understanding the mechanisms by which cis-regulatory element turnover gene

50 nomic demand analysis to demonstrate a novel mechanism by which cocaine potency is determined in vivo

51 id cohesion and chromosome organization, the mechanism by which cohesin rings are loaded onto DNA is

52 rus interactions and summarize the molecular mechanisms by which commensal microbes act on hosts and

53 Equipped with a mechanism by which complex information can be rapidly re

54 Characterizing the mechanisms by which coronavirus infection dictates patho

55 Here we elucidate the mechanism by which CXCR4 inhibition affects the tumor im

56 The results here demonstrate a possible mechanism by which CypD achieves this and suggest that d

57 Our results demonstrate a novel mechanism by which cystic epithelial cells stimulate myo

58 ctivated F-actin binding as a mechanosensing mechanism by which cytoskeletal tension can govern nucle

59 lly derived framework, we uncover a specific mechanism by which D2 dopamine receptor activity modulat

60 The findings delineate mechanisms by which decreased hepatocyte autophagy promo

61 The mechanisms by which diet impacts metabolic genes through

62 We further aim to explore the mechanisms by which disease perturbations could cause ch

63 enerative disease pathogenesis; however, the mechanisms by which disrupted NCT causes neurodegenerati

64 -induced changes in mGlu5 signaling may be a mechanism by which disruptions in negative-outcome updat

65 ering paths presents a relatively unexplored mechanism by which diversity could emerge.

66 (2020) report a previously uncharacterized mechanism by which DNMT3A loss confers increased fitness

67 ss of pancreatic cancer tumor cells, but the mechanisms by which Dyn2 regulates changes in the actin

68 ng single-molecule analyses, we examined the mechanism by which E449K activates Int for gp3-independe

69 To better understand the mechanism by which each complex distinctly modulates Hip

70 Here, we investigated the mechanism by which ECT2 engages UBF1 on rDNA promoters.

71 Here we sought to characterize the mechanism by which EHD1 couples with SNX17 to regulate r

72 However, the mechanism by which EHD1 is coupled to various receptors

73 nt among disparate habitats is a fundamental mechanism by which energy, nutrients, and biomass are tr

74 However, the underlying mechanism by which ethanol causes toxicity in muscle is

75 Despite the fact that this reveals a mechanism by which evolution could drive a pathogen to c

76 wever, there is limited understanding of the mechanisms by which experience drives circuit reorganiza

77 s makes this an excellent model to study the mechanisms by which extracellular matrix macromolecules

78 However, the mechanism by which FACT causes these opposing outcomes i

79 Thus, we uncover one mechanism by which fat oxidation can be sustained for lo

80 Probing the neural mechanisms by which features become bound into meaningfu

81 However, the mechanism by which FlrC regulates transcription is not f

82 To investigate the mechanism by which FOP-ACVR1 enhances pSmad1/5 activatio

83 In this study, we investigate the mechanism by which formin-2 (FMN2) orchestrates the init

84 The mechanisms by which G-quadruplexes transition from one f

85 ith CAD, there is mounting evidence that the mechanism by which glucose is managed can have a substan

86 This study provides a mechanism by which GRK4, via regulation of renal ETBR fu

87 cell differentiation represents a potential mechanism by which H3.3 G34 mutations drive these tumors

88 NAc expresses various HA receptor subtypes, mechanisms by which HA modulates NAc circuit dynamics ar

89 Elucidating the mechanisms by which HCMV stimulates monocyte survival is

90 ion contains residues that play roles in the mechanisms by which heat, mechanical stretch, and pharma

91 However, the mechanism by which HFD/obesity induces chondrocyte apopt

92 The mechanisms by which hibernation is achieved in microspor

93 Next, we discuss mechanisms by which histone variants influence chromatin

94 hemolymphs, highlighting a novel "bottom-up" mechanism by which host diet can impact both pathogen an

95 observed in some gliomas(1-5); however, the mechanisms by which hypermutation develops and whether i

96 For example, the mechanisms by which i) nanoscale materials can improve t

97 These results demonstrate mechanisms by which IDL improves skin hydration and epid

98 in specific cell types, thereby revealing a mechanism by which IEDs disrupt medial temporal lobe-dep

99 These findings demonstrate a novel mechanism by which IFN-I regulate immunological memory a

100 ing IL-17A-driven effects, but the molecular mechanism by which IL-17A regulates IkappaBzeta expressi

101 Nothing is known about the mechanisms by which increased ceramide levels in the lun

102 ter understanding the molecular and cellular mechanisms by which increased pressure promotes GBM inva

103 ent data have begun to uncover the molecular mechanisms by which inflammation - driven by Toll-like r

104 ource of the inflammatory mediators, and the mechanisms by which inflammation may inhibit immunity.

105 l for the emergence of hypertension, yet the mechanisms by which inflammatory mediators contribute to

106 g assay, we discovered a novel osmosensitive mechanism by which intron 1 positively mediates glutamin

107 ound in human protein extracts; however, the mechanism by which it enters the proteome is still uncle

108 The mechanism by which it impacts PDAC is yet to be explored

109 igate its photoacclimation behaviors and the mechanisms by which it dissipates excess energy.

110 , its role in lung injury resolution and the mechanisms by which it regulates angiogenesis remain unc

111 However, the mechanism by which KRAS regulates p53 is largely unknown

112 The mechanisms by which LLTS affect the central neural circu

113 ells specific for proinsulin, we studied the mechanisms by which LNSC regulate low-avidity autoreacti

114 l to impact on tissue homeostasis provides a mechanism by which load-induced tissue behaviour is regu

115 These data provide insight into the mechanisms by which lung macrophages dampen allergen-ind

116 ts identify three distinct but complementary mechanisms by which LXRalphabeta governs T lymphocyte ed

117 However, the mechanism by which m-Tyr damages cells is unclear.

118 The mechanisms by which macrophages regulate intestinal epit

119 However, the mechanisms by which major histocompatibility complex-ass

120 Spin Hall effect (SHE), a mechanism by which materials convert a charge current in

121 The mechanism by which maternal obesity influences fetal bra

122 Our study elucidates the mechanism by which meiotic cells modulate their kinetoch

123 hase separation is emerging as the universal mechanism by which membraneless cellular granules form.

124 These results highlight the mechanisms by which memories are used to prepare for upc

125 ivalents in the form of NADH as an important mechanism by which metabolic activity modulates inflamma

126 Yet, the molecular mechanisms by which METH causes neurodevelopmental defec

127 However, the mechanism by which METTL2 identifies specific tRNA argin

128 es through excreted metabolites represents a mechanism by which microbiomes with beneficial effects o

129 The mechanisms by which microbiomes impact on cancers can yi

130 They support a mechanism by which microglia use the vasculature to migr

131 ablished role of mitochondria in cancer, the mechanisms by which mitochondrial Ca(2+) (mtCa(2+)) regu

132 Our findings provide a mechanism by which mnemonic prediction errors may drive

133 e Ag dependence of signal 4 and the specific mechanisms by which MoAPC-Trm interactions affect the lo

134 rements for MALT1 monoubiquitination and the mechanism by which monoubiquitination activates MALT1 ha

135 The mechanisms by which morphogens spread through a tissue t

136 ve of the present study was to determine the mechanisms by which MoTeRs promote telomere instability.

137 However, the molecular mechanisms by which mucus affords this protection are un

138 ng can help determine the logic and cellular mechanisms by which multiple local synaptic changes prod

139 The mechanisms by which mutant huntingtin (mHTT) leads to ne

140 cept that altered splicing might be a common mechanism by which mutations cause disease.

141 Our data suggest a possible disassembly mechanism by which N-terminal ubiquitination and the pro

142 roperties represents a potentially important mechanism by which nanoparticles induce biological effec

143 estis, to better understanding the molecular mechanism by which NC1-peptide regulated spermatogenic f

144 The mechanism by which netropsin binds to hairpin DNA remain

145 The regulatory mechanisms by which neurons coordinate their physiology

146 Until now, the mechanism by which NIS transports different anion substr

147 This work provides novel insight into the mechanisms by which nitric oxide, which is produced in h

148 However, the molecular mechanisms by which NLRP6 function is inhibited to preve

149 interaction have been studied, the complete mechanism by which NS1 antagonizes RIG-I signaling remai

150 However, the mechanisms by which NUCKS1 positively impacts these proc

151 In order to unravel the mechanisms by which nucleosomes can influence, or be alt

152 The mechanisms by which obesity and hypertension may synergi

153 ts autoreception may be an important circuit mechanism by which octopamine modulates behavior.

154 The molecular mechanisms by which one ancestral rDNA set is selected f

155 One mechanism by which oxidant exposure could have long-term

156 Collectively, this work defines a novel mechanism by which p190A and E-cadherin cooperate in mod

157 nd roles of specific PATs and reveal a novel mechanism by which palmitoylation controls axonal retrog

158 ical and biochemical approaches to elucidate mechanisms by which pathogenic DDX3X variants disrupt br

159 Collectively, our study reveals a novel mechanism by which PCH1 and PCHL regulate diverse light

160 The mechanisms by which PD-1/PD-L1 inhibition elicits anti-t

161 However the mechanisms by which periodontal pathogens influence the

162 These findings provide insight into the mechanisms by which PGE(2) promotes tumor development an

163 The mechanisms by which phlebotomy promotes the mobilization

164 The molecular mechanism by which plants defend against plant root-knot

165 ggesting that sensing of iron depletion is a mechanism by which plants recognize a pathogen threat.

166 The mechanisms by which plants coordinately respond to disti

167 However, the mechanisms by which plants sense temperature are not wel

168 rently, we have limited understanding of the mechanisms by which Plasmodium parasites induce CM.

169 Our study revealed a new mechanism by which platelets promote the metastasis of c

170 d CD reveals the complexity of the molecular mechanisms by which polymorphisms affect diseases.

171 These findings provide evidence for a mechanism by which PPARalpha attenuates hepatic inflamma

172 Nonetheless, the mechanism by which PRC2 engages with native-like chromat

173 The mechanisms by which prostate cancer shifts from an indol

174 es are expected to play a direct role in the mechanisms by which proteins target and interact with LD

175 However, the molecular mechanism by which proteoglycans regulate signal transdu

176 Our results demonstrate a novel mechanism by which PS1 modulates microglial function and

177 The purpose of this study was to elucidate mechanisms by which PXN affects cancer growth and progre

178 docrine specification and identify conserved mechanisms by which RA signaling directs pancreatic endo

179 However, the mechanisms by which Rab27 contributes to airway inflamma

180 The underlying ionic mechanisms by which reduced Na(v) availability in Fhf2 k

181 recent findings point to a dedifferentiation mechanism by which reprogramming transcription factors O

182 Collectively, our data uncover a novel mechanism by which RFWD3 destabilizes forks in BRCA2-def

183 New information has emerged on the mechanisms by which RGS proteins modulate the efficacy o

184 Mechanisms by which Ric-8A catalyzes these activities, w

185 Moreover, the mechanisms by which Rit2 controls PKC-stimulated DAT end

186 However, the mechanism by which RPH3A is recruited only to PM PtdIns4

187 ent BSL-3 work with SARS-CoV-2 yet study the mechanisms by which SARS-CoV-2 enters and exits human ce

188 have been up to the task of deciphering the mechanisms by which SARS-CoV-2 induces the multisystem a

189 Our results reveal a mechanism by which satellite repeats regulate global gen

190 The mechanisms by which SCN8A variants lead to epilepsy are

191 ated role in semaphorin biology, providing a mechanism by which Sema6s may balance cis and trans func

192 ence (RNAi) process encompasses the cellular mechanisms by which short-noncoding RNAs posttranscripti

193 The study advances understanding of the mechanisms by which sHSPs achieve their chaperone activi

194 cruitment during mitosis and illuminates the mechanism by which signaling enzymes regulate this proce

195 Our findings revealed a novel mechanism by which SLB1 targets BS1 for degradation to r

196 This revealed a guidance mechanism by which SlitC constantly limits growth cone e

197 Our findings demonstrate a mechanism by which smaller copy number variations, not i

198 dual lineage tracing mouse to understand the mechanism by which SMC phenotypic transitions affect les

199 We therefore lack a consolidation of the mechanisms by which sociality impacts reproduction.

200 Q and ExoT in spacer adaptation and reveal a mechanism by which spacer orientation is defined in E. c

201 ly Mud/NuMA and cortical dynein, the precise mechanism by which spindles detect and align with the lo

202 ed with adverse metabolic health, may be one mechanism by which SSB consumption contributes to higher

203 The mechanism by which stemness and differentiation signalin

204 These studies uncover a novel mechanism by which stress sensing by neurons is coupled

205 n of negative affective states; however, the mechanisms by which stress increases amygdala-dmPFC syna

206 Identifying mechanisms by which stress regulates attention may guide

207 As such, social buffering is one mechanism by which strong social support increases resil

208 The mechanisms by which such elements work are largely unkno

209 lly-relevant conditions to delineate a novel mechanism by which Synaptotagmin-1 and Complexin act syn

210 The results demonstrate a wholly novel mechanism by which T-helper (T(H) ) polarization is gove

211 Although the mechanism by which T. brucei infection causes these chan

212 immunopathology in LF pathogenesis, but the mechanisms by which T cells influence disease severity a

213 However, the mechanisms by which T3SS1 is repressed in vivo are uncle

214 y therapeutics and facilitate to uncover the mechanisms by which TARPs modulate the receptor.

215 However, the exact mechanisms by which TBC1D23 regulates cargo transport ar

216 The molecular mechanism by which TCF21 regulates SMC phenotype is not

217 Our data therefore provide a mechanism by which TDP-43 dysfunction interferes with de

218 reast cancer migration and invasion, but the mechanism by which TGF-beta signaling converts into cell

219 However, the mechanism by which the adiponectin signaling pathway att

220 Here, we describe a mechanism by which the ARF tumor suppressor binds PPM1G

221 ce for disease tolerance as an immunological mechanism by which the bat reservoir asymptomatically ho

222 te analyses identify a frontostriatal neural mechanism by which the brain may untangle the 'curse of

223 mal nuclear shape and human pathologies, the mechanism by which the cancer nucleus becomes misshapen

224 and uncover a previously unknown regulatory mechanism by which the catalytic activity of OTUD3 is ti

225 The modulation of CPLX3 may be a mechanism by which the clock controls the cone synaptic

226 nism of action, with a specific focus on the mechanism by which the cytosolic C terminus of the synap

227 cing as a cell-intrinsic epigenetic feedback mechanism by which the duration of the transcriptional r

228 We also demonstrate a possible mechanism by which the evaluation and learning of utilit

229 Altogether, we identified a mechanism by which the host scales immune responses acco

230 Here, we uncover a novel mechanism by which the human papillomavirus (HPV) inhibi

231 These data suggest a mechanism by which the hydroxylase is tuned for converti

232 Here, we describe a mechanism by which the innate immune system allows rapid

233 n with protein engineering, we explicate the mechanism by which the intrinsically unstructured N-term

234 tion resulting from coincidence detection, a mechanism by which the MB integrate two spatially distin

235 y was undertaken to understand the molecular mechanism by which the mechanosensitive cation channel,

236 njury to the central nervous system, but the mechanism by which the membrane-bound Nogo-A is presente

237 Furthermore, we delineate the mechanism by which the mitochondria, through MUL1 ligase

238 well as awake mice, pointing to a potential mechanism by which the olfactory cortex can actively and

239 However, the molecular mechanism by which the OX40 cosignaling regulates the T-

240 Antibody-dependent enhancement (ADE) is a mechanism by which the pathogenesis of certain viral inf

241 nd blood pressure substantially, providing a mechanism by which the RVLM could contribute chronically

242 These findings define a mechanism by which the same signaling pathway promotes b

243 The reaction mechanism by which the shelterin protein POT1 (Protectio

244 furan (THF):water pretreatment and provide a mechanism by which the solvent components drive efficien

245 However, the mechanism by which the UBQLN2 mutations cause disease re

246 However, the mechanisms by which the activation of SARM1 is stringent

247 We then consider mechanisms by which the activity of multiple niche cell

248 mutations is well established; however, the mechanisms by which the background interacts with Mendel

249 Our results help to understand the mechanisms by which the brain merges auditory and visual

250 The mechanisms by which the cerebellum impacts seizures, how

251 se findings advance our understanding of the mechanisms by which the early synergism between antibody

252 These findings suggest mechanisms by which the enigmatic cytokine IL-17F contri

253 The mechanisms by which the environment, including high-alti

254 Here, we discuss potential mechanisms by which the immune system affects the centra

255 uring liver repair have been identified, the mechanisms by which the injured liver maintains vital fu

256 sical insights into the understanding of the mechanisms by which the PS film attains low surface tens

257 However, the mechanisms by which the stress pathway interferes with h

258 We investigated the mechanisms by which the Western diet promotes tumor recu

259 The mechanism by which these different groups are added to t

260 isease activity(3-5); however, the molecular mechanism by which these fibroblasts differentiate and e

261 However, the mechanism by which these small RNAs inhibit translation

262 ance of CDC-producing bacteria; however, the mechanisms by which these cells evade the deleterious ef

263 stituted phospholipid bilayers; however, the mechanisms by which these changes happen are still large

264 n error reporting, little is known about the mechanisms by which these cultural characteristics influ

265 However, understanding the mechanisms by which these genetic variants have an impac

266 The mechanisms by which these immune cells converge on targe

267 The mechanism by which they disrupt mitochondrial cristae, h

268 d reduced ejection fraction (HFrEF), but the mechanism by which they improve outcomes remains unclear

269 onducted in model solution to understand the mechanisms by which they are involved in haze formation.

270 f S. suis have been extensively studied, the mechanisms by which they damage the central immune organ

271 ough direct physical interactions, molecular mechanisms by which they interact are not clear.

272 of the retina is assembled, and the distinct mechanisms by which they regulate dendritic growth to ge

273 ine-induced CEnC death, and to elucidate the mechanism by which this cytoprotection occurs.

274 ond, we provide evidence of an informational mechanism by which this early investment in infrastructu

275 recent key findings that have revealed a new mechanism by which this molecule influences dynein-media

276 tides (cAMP and/or cGMP), but the allosteric mechanism by which this occurs is incompletely understoo

277 The mechanisms by which this heritable priming occurs are la

278 ly occurring features of a stimulus, yet the mechanisms by which this integration occurs are not full

279 Mechanisms by which this is accomplished include AR ampl

280 hogen invasion-but little is known about the mechanisms by which this occurs.

281 for ACh-induced inhibition of contraction, a mechanism by which those channels in smooth muscle are t

282 l framework has identified potentially novel mechanisms by which tissue WF exposure may lead to gene

283 SLE in patients and in mouse models, but the mechanism by which TLR signaling to self-ligands is regu

284 pressure and neural plasticity; however, the mechanism by which TNFalpha signaling contributes to the

285 ost importantly, we describe an entirely new mechanism by which transposons can promote genomic alter

286 Here we explored the molecular mechanisms by which Trial 2 achieves the essential prolo

287 ates will likely identify novel proteins and mechanisms by which TRIM9 and TRIM67 regulate neuronal f

288 bility to acquire chromosomal alterations, a mechanism by which tumor cells evolve, adapt, and resist

289 However, the neural mechanisms by which unattended, but future-relevant, inf

290 s oncogenic, although the detailed molecular mechanisms by which uncontrolled NRF2 activation promote

291 nization of response subspace and suggests a mechanism by which value-related signals are prevented f

292 elevant cell types/states, target genes, and mechanisms by which variants can cause diseases or alter

293 They further provide a potential mechanism by which vascular interactions facilitate micr

294 Yet the mechanisms by which viable interneurons are produced fro

295 ondria and degraded, providing an additional mechanism by which viperin reduces HADHB activity.

296 However, the mechanism by which virulence is regulated by PE synthesi

297 ication requires a detailed understanding of mechanisms by which viruses coopt vesicular trafficking.

298 Together, these results provide a potential mechanism by which widely reported individual difference

299 However, the mechanism by which WRN protects MSI-associated cancers f

300 er, our findings shed light on the molecular mechanism by which ZNF750 regulates cell migration and i