ライフサイエンスコーパス: mechanochemical

1 lowed us to interrogate the mechanism of the mechanochemical [2 + 2] cycloreversion.

2 Mechanochemical activation achieved by grinding, shearin

3 Mechanochemical activation of a furan-maleimide Diels-Al

4 The mechanochemical activation of cis-gem-difluorocyclopropa

5 ture results in stress-concentration-induced mechanochemical activation of mechanophores, significant

6 oGEF) analyses allowed us to interrogate the mechanochemical activation of these adducts.

7 tion of methane with TCCA and evidenced that mechanochemical activation permitted significantly lower

8 needed, the degradability can be unlocked by mechanochemical activation that converts the polyCBL int

9 nt shifts in molecular weight thresholds for mechanochemical activation that depend on the structure

10 ation provides spatiotemporal control of the mechanochemical activation through targeted but noninvas

11 r substitution pattern leading to successful mechanochemical activation.

12 hanochemical products further shows that the mechanochemical "activation zone" in the cyclic polymer

13 t high resolution and will shed light on the mechanochemical activity of G-quadruplex-binding machine

14 gation of the endocytic profiles require the mechanochemical activity of the myosins-I.

15 nd demonstrated to be reliable indicators of mechanochemical activity.

16 s five domains that together orchestrate its mechanochemical activity.

17 Mechanochemical analogues have recently been established

18 dynein at five separate points in the dynein mechanochemical and transport cycles.

19 The products were obtained via a mechanochemical approach by simple grinding of 1-haloalk

20 We describe the development of a mechanochemical approach for Ru-catalyzed olefin metathe

21 Herein, a mechanochemical approach is demonstrated to afford highl

22 Additionally, the mechanochemical approach is shown to enable the efficien

23 A mechanochemical approach was used to prepare correspondi

24 tion of planetary ball mills has extended to mechanochemical approaches.

25 areas exceeding 1,000 m(2) g(-1), based on a mechanochemical assembly between polyphenol-metal comple

26 Many questions remain about how the kinesin mechanochemical ATPase cycle is fine-tuned for specific

27 lar synthesis, few have addressed the use of mechanochemical ball milling for the synthesis of compou

28 , X = Cl, Br, or I) are prepared by a simple mechanochemical ball-milling method, which allows low-co

29 g and isotope-labeled solids, we reveal that mechanochemical ball-milling overcomes inherently slow s

30 We describe and analyze a model of mechanochemical-based adaptation coupling a mechanics-ba

31 To gain insight into the mechanochemical basis underlying junction mechanosensiti

32 tin binding and contribute critically to the mechanochemical behavior of stress fibers, actin arcs, a

33 ophore, dichlorocyclopropane, resulting in a mechanochemical cascade reaction.

34 Here, we present a comprehensive mechanochemical characterization of a homomeric ring ATP

35 ched sister chromosomes to facilitate robust mechanochemical checkpoint signaling.

36 erstanding of the mechanisms and pathways of mechanochemical cocrystal formation.

37 rate and increasing product diversity during mechanochemical cocrystallization reactions.

38 azoacetate derivatives can be achieved under mechanochemical conditions using metallic silver foil an

39 lvent-free pyrrole synthesis performed under mechanochemical conditions with a TMSOTf-catalyzed oxoni

40 This study uncovers a novel mechanochemical connection between Galphaq/PLCbeta /PI(4

41 Integrin adhesion complexes (IACs) form mechanochemical connections between the extracellular ma

42 prototypical dynamin, Drp1 is composed of a mechanochemical core consisting of the GTPase, middle, a

43 Furthermore, the mechanochemical core of Drp1, absent of the variable dom

44 Based on these insights, we propose a mechanochemical coupled triggering hypothesis to explain

45 Finally, regiochemical effects on mechanochemical coupling are characterized, and increasi

46 eversibly in either direction requires tight mechanochemical coupling between the catalytic domain an

47 emonstrate that such interfacially-triggered mechanochemical coupling can be recapitulated in vitro b

48 The mutated residue acts like a mechanochemical coupling element--it transmits changes b

49 The general principles of this mechanochemical coupling have been established; however,

50 analyte recognition and signal reporting by mechanochemical coupling in a single-molecule DNA templa

51 In-depth analysis of mechanochemical coupling in molecular motors has made th

52 s improved our ability to accurately measure mechanochemical coupling in motor proteins is ensemble a

53 refore there is a need to accurately measure mechanochemical coupling in motors in both health and di

54 Here we present a current understanding of mechanochemical coupling in this essential molecular mac

55 Our findings indicate a mechanochemical coupling in which physical forces regula

56 eration enables detailed explorations of the mechanochemical coupling mechanisms in experiment and si

57 It is argued that the relatively weak mechanochemical coupling might allow transcription to be

58 The determined tight mechanochemical coupling of 1.1 +/- 0.2 ATP consumed per

59 orientation of the lid subdomain may mediate mechanochemical coupling of ATP hydrolysis and DNA trans

60 11 from S. cerevisiae and the mechanisms for mechanochemical coupling of substrate degradation and de

61 In living cells, mechanochemical coupling represents a dynamic means by w

62 hich nonmotor proteins work collectively via mechanochemical coupling to propel cargos-an ingenious s

63 the scissile bond in the mechanophore (i.e., mechanochemical coupling).

64 nts involved in motor-substrate interaction, mechanochemical coupling, and intersubunit coordination.

65 onger carbon-sulfur bond is ascribed to poor mechanochemical coupling, at least in part as a result o

66 ng the P-loop arginine in ATP hydrolysis and mechanochemical coupling.

67 salient points that aid our understanding of mechanochemical coupling.

68 rowth Factor 20 (FGF20)-cell aggregate-based mechanochemical coupling.

69 duct becomes inert under tension due to poor mechanochemical coupling.

70 rations and do not account for physiological mechanochemical couplings.

71 has prevented a complete description of its mechanochemical cycle and limited insight into how seque

72 ay and converter domains is essential to the mechanochemical cycle and sarcomere assembly.

73 stepping by the tethered head, leading to a mechanochemical cycle in which processivity is determine

74 of the N- and C-terminal regions during the mechanochemical cycle of all kinesins and kinesin-relate

75 tiple motors to derive information about the mechanochemical cycle of individual ncd motors.

76 Therefore, the mechanochemical cycle of kinesin-14 (ncd) is still under

77 le lattice in combination with the diffusive mechanochemical cycle of the motor.

78 how SMCs structure chromosomes and how their mechanochemical cycle regulates their interactions with

79 tate and that this state arises later in the mechanochemical cycle than the state that gives rise to

80 We propose a revised model of dynein's mechanochemical cycle which accounts for our findings.

81 During the myosin mechanochemical cycle, ATP-induced twisting of the relay

82 le for force sensitivity in this step of the mechanochemical cycle.

83 nd Ncd towards physical understanding of its mechanochemical cycle.

84 biological motors which walk by repeating a mechanochemical cycle.

85 by directly blocking the progression of its mechanochemical cycle.

86 erization of the individual states along the mechanochemical cycle.

87 and reproduce the energetics of the complete mechanochemical cycle.

88 large conformational changes during Hsp90's mechanochemical cycle.

89 would be significantly disrupted during the mechanochemical cycle.

90 iological functions despite sharing a common mechanochemical cycle.

91 al rearrangements associated with the dynein mechanochemical cycle.

92 trol by affecting distinct steps in myosin's mechanochemical cycle.

93 es to elucidate the role of AAA4 in dynein's mechanochemical cycle.

94 vity of kinesins, Kif7 modulates the tubulin mechanochemical cycle.

95 the motor for a significant portion of their mechanochemical cycles at low loads.

96 been used with great success to explore the mechanochemical cycles of processive motor proteins such

97 requires gating mechanisms to coordinate the mechanochemical cycles of the two motor heads to sustain

98 od which features coordinate, or "gate," the mechanochemical cycles of the two motor heads.

99 The mechanochemical decellularization system removed 93% of

100 Mechanochemical derivatizations of N- or C-protected ami

101 putational model provides the first complete mechanochemical description of the motor protein dynein,

102 Mechanochemical disruption also impeded HCC migration an

103 Our analysis revealed that mechanochemical disruption caused a significant overprod

104 The cells that survived mechanochemical disruption had a reduced expression of c

105 These results show that mechanochemical disruption inhibits uncontrolled prolife

106 Mechanochemical disruption of cellular structures can po

107 ormation to a non-tumorigenic phenotype post mechanochemical disruption was confirmed by a lack of tu

108 and biophysical assays, we have undertaken a mechanochemical dissection of the microtubule-bound MKLP

109 aracterized myosins and clearly demonstrates mechanochemical diversity within the myosin family.

110 /3 were studied using a computational model (mechanochemical dynamics of active networks [MEDYAN]); t

111 cular the cell cytoskeleton, exhibit complex mechanochemical dynamics that are still not well underst

112 A rationale for the mechanochemical effect on this photoisomerization mechan

113 cal action can produce dramatic physical and mechanochemical effects when the energy is spatially or

114 Thus, the mechanochemical efficiencies of different motor types ma

115 us to construct a dynamical theory for this mechanochemical engine consistent with our experimental

116 istic action of structural coat proteins and mechanochemical enzymes to deform and sever the plasma m

117 nks, leading to polymer unfolding instead of mechanochemical events at the backbone.

118 esulting from a well-coordinated sequence of mechanochemical events--suggests a complex emergent beha

119 wing for restoration of chemical bonds after mechanochemical events.

120 iation of graphite in styrene results in the mechanochemical exfoliation of graphite flakes to single

121 are frequently used as force transducers in mechanochemical experiments and identified DIBAC (azadib

122 lecules and thereby contributes to a complex mechanochemical feedback loop.

123 tured like a control system characterized by mechanochemical feedback loops that regulate myosin II l

124 ish epithelial keratocyte-to define a set of mechanochemical feedback loops underlying actin network

125 Finally, we focus on mechanochemical feedback, where signaling proteins can e

126 We propose that the mechanochemical feedbacks underlying wave generation in

127 and external stimuli such as heat, light or mechanochemical force cause such structural transformati

128 and external stimuli such as heat, light or mechanochemical force cause such structural transformati

129 Here, we incorporate a mechanochemical free-energy-based approach to elucidate

130 size than the polyladderene system and allow mechanochemical generation of conjugated polymers beyond

131 ve been synthesized by solvent drop-assisted mechanochemical grinding method, and all of them exhibit

132 ynthesized via room-temperature solvent-free mechanochemical grinding.

133 namin-related protein 1 (Drp1) is a critical mechanochemical GTPase that drives constriction during m

134 escent protein (GFP)-tagged dynamin, a large mechanochemical guanosine triphosphate (GTP)ase implicat

135 These results provide new mechanochemical insights into the influences and the mec

136 This mechanochemical integration allows for the rapid product

137 tailed insight into the kinetics of myosin's mechanochemical interaction with actin.

138 The model demonstrates that in principle, mechanochemical interactions are sufficient to drive pat

139 g and experimental perturbation to show that mechanochemical interactions are sufficient to generate

140 he thick filament that appears to tune these mechanochemical interactions by its N-terminal domains t

141 ymer of gated gDCC than of free gDCC for the mechanochemical isomerization gDCC to proceed at equal r

142 ntitatively, the results agree with a simple mechanochemical kinetics model.

143 The mechanochemical kinetics, single-chain extensibility, to

144 s share a common evolutionary structural and mechanochemical mechanism for force generation.

145 We propose that this mechanochemical mechanism is critical to boost ADF/cofil

146 r mechanical pathways, yet few have explored mechanochemical mechanisms.

147 A mechanochemical method for the preparation of synthetica

148 This easy-handling mechanochemical methodology was applied to a large varie

149 d spotlight selected applications of quantum mechanochemical methods to point out their synergistic r

150 onalised Ar-BIAN ligand was carried out by a mechanochemical milling approach, which was advantageous

151 Microwave, ultrasound, sunlight and mechanochemical mixing can be used to augment convention

152 Our data are consistent with a mechanochemical model in which PMF-driven motors, simila

153 hese observations, we developed a stochastic mechanochemical model of supercoiling-induced transcript

154 We also present a mechanochemical model that accounts for single-molecule,

155 Here, we propose a simple mechanochemical model that explains the dependence of ce

156 These results lead to a four-state mechanochemical model that provides insights into the me

157 Our results thus support a mechanochemical model where a chemosensory system measur

158 e result is consistent with predictions of a mechanochemical model, and suggests an active mechanical

159 of amoeboid locomotion emerge from a simple mechanochemical model.

160 d computational modeling, especially coupled mechanochemical modeling, has contributed significantly

161 imited single-directional chemomechanical or mechanochemical modes.

162 ation of cryptic cysteines in titin mediates mechanochemical modulation of the elasticity of human ca

163 The finding that condensin is a mechanochemical motor has important implications for und

164 is generally applicable to shed light on the mechanochemical operating modes of large molecular engin

165 role of shape as an integral element of the mechanochemical organization of morphogenetic processes.

166 mulations reveal how contraction scales with mechanochemical parameters.

167 Thus, we elucidate a mechanochemical pathway in which arterial shear activate

168 al principles of the establishment of active mechanochemical patterns and point toward future directi

169 We also show that the structure of bulk mechanochemical perovskites bears close resemblance to t

170 activity of biological macromolecules from a mechanochemical perspective.

171 The theoretical explanation of mechanochemical phenomena is difficult, as the mechanism

172 s could attenuate (as opposed to facilitate) mechanochemical phenomena.

173 Here we report a mechanochemical phenomenon in graphene oxide membranes,

174 f versatile DNA origami nanostructures, this mechanochemical platform is anticipated to offer a long

175 We propose a general mechanochemical polarization model based on coupling bet

176 To gain a better understanding of the mechanochemical potential of KIF3AC, we pursued a single

177 By applying a mechanochemical procedure to induce bioluminescence anal

178 A mechanochemical procedure was developed to obtain PZ-136

179 ble to acquire directly information during a mechanochemical process.

180 dscape that reproduces the energetics of the mechanochemical process.

181 the key to gain an in-depth understanding of mechanochemical processes at the molecular level.

182 Mechanochemical processes in thin biological structures,

183 How these mechanochemical processes influence function in vivo is

184 emble peristaltic waves from self-organized, mechanochemical processes on the deforming surface.

185 in turn allow more sophisticated analysis of mechanochemical processes, extending the limits of the t

186 Ozonolysis of the mechanochemical products further shows that the mechanoc

187 These results suggest that the mechanochemical properties of KIF3AC can be explained by

188 experiments showing that the load-dependent mechanochemical properties of mutant NM II support effic

189 el for FHC has been widely used to study the mechanochemical properties of mutated cardiac myosin, bu

190 is region plays a general role in tuning the mechanochemical properties of myosins.

191 3822P, strongly interfere with dynein's core mechanochemical properties.

192 measurements of a single motor's elastic and mechanochemical properties.

193 contiguous cell walls indeed exhibit hybrid mechanochemical properties.

194 lar matrix (ECM) has force-responsive (i.e., mechanochemical) properties that enable adaptation to me

195 omic force microscopy for the observation of mechanochemical proteins onto membranes during action at

196 We report that a mechanochemical reaction in a ball mill exhibits unusual

197 gy that should be considered in the study of mechanochemical reaction mechanisms.

198 The mechanochemical reaction produces macroscopic single cry

199 Usually, mechanochemical reactions between solid phases are eithe

200 bones, and it is demonstrated here that such mechanochemical reactions can be used to strengthen a po

201 Mechanochemical reactions effected by milling or grindin

202 duration of exposure is employed to activate mechanochemical reactions in a cross-linked elastomeric

203 he progress in homogeneous and heterogeneous mechanochemical reactions in oxides of various structure

204 tigations into the mechanical properties and mechanochemical reactions of metal-organic frameworks (M

205 In general, mechanochemical reactions predicted with the CoGEF metho

206 ixture must be appreciated to understand how mechanochemical reactions progress.

207 active compounds exclusively performed using mechanochemical reactions.

208 eory was used to understand the mechanism of mechanochemical reactions.

209 nsduction and product distribution in tandem mechanochemical reactions.

210 ticomponent nanosystems and peculiarities of mechanochemical reactions.

211 for effective energy transduction in tandem mechanochemical reactions.

212 The mechanochemical reactivity of bis-naphthopyran is suppor

213 y can be potentially utilized to control the mechanochemical reactivity of molecular objects.

214 We demonstrate that the mechanochemical reactivity of naphthopyran is critically

215 ein we report the discovery of the intrinsic mechanochemical reactivity of vinyl-addition polynorborn

216 e reported to date and compare the predicted mechanochemical reactivity to experimental results.

217 GEF method as a powerful tool for predicting mechanochemical reactivity, enabling its widespread adop

218 tion for a new strategy by which to engineer mechanochemical reactivity.

219 on a molecule and enables the prediction of mechanochemical reactivity.

220 get molecule to any of these probes leads to mechanochemical rearrangement of the origami nanostructu

221 sing genetic ablation, quantitative imaging, mechanochemical reconstitution and atomic force microsco

222 sect the specific interactions mediating the mechanochemical relay, we used affinity purification/mas

223 s, for example, the dynamics of physical and mechanochemical remodeling of loaded materials.

224 this contribution has long been involved in mechanochemical research in both inorganic and organic s

225 tutorial review turns the spotlight towards mechanochemical research in the field of inorganic main

226 The unique dual mechanochemical response of STP makes it of potentially

227 Here we probe the mechanochemical response of two tetra(4-bromophenyl)porp

228 focal adhesions leads to a complex, dynamic, mechanochemical response.

229 ond scission of interest and the nonscissile mechanochemical ring opening of gem-dichlorocyclopropane

230 Pulsed ultrasonication leads to the mechanochemical ring opening of the MeO-gDCC and the sub

231 To probe the dynamics of the mechanochemical ring opening, a series of bicyclo[4.2.0]

232 fragment under mechanical stress through the mechanochemical scission of covalent bonds in the backbo

233 roducts suggests that the ultrasound-induced mechanochemical scission of the oxime sulfonate mechanop

234 expanded single-molecule platforms in a new mechanochemical sensing strategy.

235 Here, we demonstrated mechanochemical sensing that broke the Kd limit by 9 ord

236 amework to simulate the interactions between mechanochemical signaling in individual cells and intera

237 Here, we examine mechanochemical signaling in response to direct force ap

238 itive intracellular structures that regulate mechanochemical signaling pathways.

239 he networks to integrins while responding to mechanochemical signaling pathways.

240 nated tumor-endothelial crosstalk, utilizing mechanochemical signaling to direct cytoskeletal rearran

241 adhesions (FAs) serve as the major hubs for mechanochemical signaling via GIV.

242 phorylation is required for TFP function and mechanochemical signaling, it is not required for polar

243 ric shape cues can play in orchestrating the mechanochemical signals and paracrine/autocrine factors

244 affects many physiological processes through mechanochemical signals from focal adhesion (FA) complex

245 rotubule catastrophe events, we performed 3D mechanochemical simulations that account for interaction

246 The mechanochemical, solvent-free, highly regioselective, rh

247 Here, we describe a novel mechanochemical specialization of the A1-GPIbalpha bond

248 ic routes, i.e., electrochemical, microwave, mechanochemical, spray drying and flow chemistry synthes

249 rly collapsed by covalent bonds show greater mechanochemical stability compared to other thermoplasti

250 nbinding probabilities corresponding to each mechanochemical state of kinesin are modeled.

251 repeatable transformations, involving eight mechanochemical states and incorporating self-righting b

252 On one hand, mechanochemical stimulation has been used to direct the

253 on mechanisms may support the translation of mechanochemical stimulation into the clinic as an emergi

254 The developed mechanochemical strategy is modular and allows for syste

255 The solid-state mechanochemical strategy is rapid and minimizes the use

256 in, we demonstrate the advantages of using a mechanochemical strategy to encapsulate enzymes into rob

257 We report a mechanochemical strategy to selectively convert methane

258 hemical signals, chemists dream of designing mechanochemical switches integrated into materials.

259 as a key step for a deeper understanding of mechanochemical symmetry breaking in Hydra.

260 The results show that mechanochemical syntheses and transformations of ZIFs ar

261 Soluble porous coordination polymers from mechanochemical synthesis are presented through a coordi

262 A solvent-free mechanochemical synthesis for 1,2,6-thiadiazine 1-oxides

263 Mechanochemical synthesis has the potential to provide m

264 We report a mechanochemical synthesis in which slow compression at r

265 Although mechanochemical synthesis is becoming more widely applie

266 Herein is reported the mechanochemical synthesis of a reticular family of cryst

267 In this review, the mechanochemical synthesis of catalysts is discussed, wit

268 In recent years, the mechanochemical synthesis of organic compounds was added

269 Here we report a solvent and catalyst-free mechanochemical synthesis of pillar[5]quinone (P5Q) deri

270 We report a mechanochemical synthesis of structurally well-defined i

271 We conclude that the key effects of mechanochemical synthesis on the properties of solid ele

272 The effects of mechanochemical synthesis that lead to increased ionic c

273 o provide a broad but digestible overview of mechanochemical synthesis, i.e. reactions conducted by g

274 e marriage of concepts of supramolecular and mechanochemical synthesis, including organocatalysis, de

275 pective as compared to conventional, gradual mechanochemical synthesis, where thermal effects are gen

276 als were prepared by solvent evaporation and mechanochemical synthesis.

277 taneously observed with COF formation during mechanochemical synthesis.

278 e for further studies in other proton-driven mechanochemical systems and should lead (when combined w

279 In this paper, emergent laws for describing mechanochemical systems are investigated for processive

280 nsight for how patterns emerge in stochastic mechanochemical systems, while also informing understand

281 ions, reinforcing predictive capabilities in mechanochemical systems.

282 of the electrostatic basis of proton-driven mechanochemical systems.

283 However, mechanochemical techniques can also alter chemical react

284 Monitoring of mechanochemical thiocarbamoylation by in situ Raman spec

285 An important mechanochemical transducer is the actin cytoskeleton.

286 e applied mechanical force and its effect on mechanochemical transduction along the reaction coordina

287 Mechanochemical transduction by myosin motors on actin i

288 Finally, we show that mechanochemical transduction in metallosupramolecular po

289 Under HIFU irradiation evidence of the mechanochemical transduction is the observation of a rev

290 rate that vimentin forms a central part of a mechanochemical transduction pathway that regulates mult

291 We describe studies in mechanochemical transduction that probe the activation o

292 milar structures for the domains involved in mechanochemical transduction--including switch-1 and the

293 Here, we report that mechanochemical transductions can be achieved in metallo

294 lid-state processes are rooted in stochastic mechanochemical transformations directed by electronic i

295 These mechanochemical transformations in a two-dimensional sys

296 s, this work defines a consensus sequence of mechanochemical transitions that can be used to understa

297 ynthesized using a two-step method including mechanochemical treatment of polyethylene glycol and ace

298 Our design is based on the facile mechanochemical unzipping of polyladderene, a polymer in

299 enes to enable both their polymerization and mechanochemical unzipping to yield semiconducting polyac

300 This periodic patterning system is partly mechanochemical, with mechanical-chemical integration oc