ライフサイエンスコーパス: mechanoelectrical

1 ssesses unique acoustic sensitivity due to a mechanoelectrical 'amplifier', which requires the metabo

2 a-catenin, are indispensable for maintaining mechanoelectrical coupling in the heart.

3 i of the cardiomyocyte, thus ensuring proper mechanoelectrical coupling throughout the myocardium.

4 I(Ks), may account in part for this form of mechanoelectrical coupling.

5 the excitation, a phenomenon referred to as mechanoelectrical feedback (MEF), via stretch-activated

6 These data suggest a novel mechanoelectrical feedback mechanism for inducing physio

7 d by membrane stretch, possibly serving as a mechanoelectrical feedback pathway.

8 To test the hypothesis that mechanoelectrical feedback triggered by regional strain

9 Dynamic mechanoelectrical feedback was modeled as spatially and

10 These data further underscore a likely mechanoelectrical interaction as an important part of th

11 lar matrix that is directly coupled with the mechanoelectrical receptors responsible for sensory tran

12 functional regulatory features of the heart-mechanoelectrical signaling and automaticity-could be tr

13 By leveraging cardiac mechanoelectrical signaling, we recreated reciprocal con

14 TRP channels and other proteins involved in mechanoelectrical signaling.

15 ons transmit and convert acoustic sound into mechanoelectrical signals, mimicking the complex cochlea

16 ought to form the ion-conducting pore of the mechanoelectrical transducer (MET) channel in auditory h

17 The molecular composition of this mechanoelectrical transducer (MET) channel is not yet kn

18 The mechanoelectrical transducer (MET) channel is the entryw

19 ice, and the resting open probability of the mechanoelectrical transducer (MET) channel reaches value

20 Mechanoelectrical transducer (MET) channel resting open

21 ay be mediated by a block of the hair cell's mechanoelectrical transducer (MET) channel, the major en

22 In lower vertebrates, when the mechanoelectrical transducer (MET) channels are opened b

23 Although gating of mechanoelectrical transducer (MET) channels has been suc

24 Although the nature of these mechanoelectrical transducer (MET) channels is still unc

25 n of the mechanical input to ensure that the mechanoelectrical transducer (MET) channels operate in t

26 d to act as the motor protein tensioning the mechanoelectrical transducer (MET) channels, thus settin

27 Finally, we showed that the size of the mechanoelectrical transducer (MET) current from IHCs dec

28 Recordings of mechanoelectrical transducer (MET) currents in cochlear

29 d bundles regained their ability to generate mechanoelectrical transducer (MET) currents in response

30 Mechanoelectrical transducer (MET) currents were recorde

31 Hair cell mechanoelectrical transducer channels are opened by defl

32 hypothesize that genetic manipulation of the mechanoelectrical transducer complex will abolish sound

33 ia and showed a reduction in the size of the mechanoelectrical transducer current from just after P9.

34 e also provide evidence that the size of the mechanoelectrical transducer current is reduced in agein

35 The mechanoelectrical transducer current is smaller in mice

36 second and third rows of stereocilia, their mechanoelectrical transducer current, and develop progre

37 Here we describe measurements of mechanoelectrical transducer currents in outer hair cell

38 Mechanoelectrical transducer currents in turtle auditory

39 Recordings of mechanoelectrical transducer currents were combined with

40 aptation properties, but not the size of the mechanoelectrical transducer currents.

41 oduce only atomic-scale displacements in the mechanoelectrical transducer, yet thermal noise causes f

42 s suggest that Gd(3+)-sensitive SACs are the mechanoelectrical transducers in baroreceptors.

43 orti (OoC), acting as bidirectional cellular mechanoelectrical transducers, generate, receive, and ex

44 Inner hair cells act as primary mechanoelectrical transducers, while outer hair cells en

45 During hair cell development, the mechanoelectrical transduction (MET) apparatus is assemb

46 eurites in the explanted frog sacculus, with mechanoelectrical transduction (MET) blocked.

47 +)- and Mg(2+)-binding protein essential for mechanoelectrical transduction (MET) by cochlear hair ce

48 The mechanoelectrical transduction (MET) channel in auditory

49 n hypothesized to play a role in the elusive mechanoelectrical transduction (MET) channel in inner ea

50 EMENT How forces are relayed to the auditory mechanoelectrical transduction (MET) channel remains unk

51 etection of sound and head movement requires mechanoelectrical transduction (MET) channels at tips of

52 Mechanoelectrical transduction (MET) channels in cochlea

53 into excitatory membrane currents carried by mechanoelectrical transduction (MeT) channels.

54 We have also shown that the mechanoelectrical transduction (MET) current from OHCs o

55 ffects of tmc1/2a/2b truncation mutations on mechanoelectrical transduction (MET) in the inner-ear ha

56 In vertebrates, this process of mechanoelectrical transduction (MET) is performed by spe

57 tion, differentiation and acquisition of the mechanoelectrical transduction (MET).

58 ical stimuli into electrical signals through mechanoelectrical transduction (MET).

59 organized structure plays a critical role in mechanoelectrical transduction and amplification.

60 n channels that maximizes the sensitivity of mechanoelectrical transduction and enhances the hair bun

61 ompatible strategies for the optimization of mechanoelectrical transduction and of an active process

62 The Piezo1 channel mediates mechanoelectrical transduction and regulates crucial phy

63 Moreover, the hair cells are capable of mechanoelectrical transduction and show basolateral cond

64 The molecular mechanisms underlying mechanoelectrical transduction and the receptors that de

65 n polymerization as well as operation of the mechanoelectrical transduction apparatus.

66 specific phenotype suggested a defect in the mechanoelectrical transduction apparatus.

67 Mechanoelectrical transduction at auditory hair cells re

68 Mechanoelectrical transduction by hair cells commences w

69 creases in endolymph that involved hair cell mechanoelectrical transduction channel block but not the

70 the stereocilia and are thought to gate the mechanoelectrical transduction channel.

71 Direct gating of mechanoelectrical transduction channels by mechanical fo

72 gentamicin demonstrated the crucial role of mechanoelectrical transduction channels in the rapid res

73 Mechanoelectrical transduction channels of hair cells al

74 The mechanoelectrical transduction channels of hair cells, b

75 n motor, Ca2+ entering a hair bundle through mechanoelectrical transduction channels regulates the se

76 ter HC region, formed stereocilia, contained mechanoelectrical transduction channels, and survived fo

77 ry epithelium and Kolliker's organ contained mechanoelectrical transduction channels, as indicated by

78 amentous connectors implicated in gating the mechanoelectrical transduction channels, is the transmem

79 tip-links, whose tension gates the hair cell mechanoelectrical transduction channels.

80 A hair cell's tip links are thought to gate mechanoelectrical transduction channels.

81 at form the hair bundle tip links gating the mechanoelectrical transduction channels.

82 ytoskeleton and with other components of the mechanoelectrical transduction complex.

83 OoC illumination altered the OHC mechanoelectrical transduction conductance operating poi

84 ectric relations whereas the OHC hair-bundle mechanoelectrical transduction current is modeled as a n

85 ngly, the endocochlear potential that drives mechanoelectrical transduction currents in outer hair ce

86 3b(-/-) cochlear hair bundles display robust mechanoelectrical transduction currents with normal kine

87 of intrinsic Ca(2+) APs leads to the loss of mechanoelectrical transduction in IHCs prior to hearing

88 Mechanoelectrical transduction in the inner ear is a bio

89 ical vibrations show little compression, and mechanoelectrical transduction in the receptor cells is

90 a virtual hair cell that simulates hair cell mechanoelectrical transduction in the turtle utricle.

91 idence suggests that the adaptation motor of mechanoelectrical transduction in vertebrate hair cells

92 that myosin Ibeta mediates the adaptation of mechanoelectrical transduction in vestibular hair cells.

93 Mechanoelectrical transduction is a cellular signalling

94 One molecule that might participate in mechanoelectrical transduction is cadherin 23 (CDH23), a

95 Inner ear hair-cell mechanoelectrical transduction is mediated by a largely

96 Mechanoelectrical transduction of acoustic signals is th

97 de that Elkin1 supports a PIEZO1-independent mechanoelectrical transduction pathway and modulates cel

98 te that there are separate, but overlapping, mechanoelectrical transduction pathways in chondrocytes.

99 input into electrical potentials through the mechanoelectrical transduction process (MET).

100 This archetypal mechanoelectrical transduction process occurs in the hai

101 hese characteristics emerge naturally if the mechanoelectrical transduction process operates near a d

102 cells of the inner ear, are essential to the mechanoelectrical transduction process underlying hearin

103 antenna of inner ear hair cells, and in the mechanoelectrical transduction process.

104 quivalence of tip links with gating springs, mechanoelectrical transduction returns over the same tim

105 Mechanoelectrical transduction takes place close to the

106 g two mutant zebrafish lines with defects in mechanoelectrical transduction, and by blocking transduc

107 We used salsa mice, a Chd23 mutant with no mechanoelectrical transduction, and deafness before p56.

108 ively lose their transducing stereocilia and mechanoelectrical transduction, and fail to acquire thei

109 s scaling contradicts the canonical model of mechanoelectrical transduction, but the results can be e

110 lacking functional Elkin1 exhibit defective mechanoelectrical transduction, decreased motility and i

111 Ca2+ is thought to be required in mechanoelectrical transduction, for exposure of hair bun

112 ulus, we observed that extensive recovery of mechanoelectrical transduction, hair bundle stiffness, a

113 To ensure optimal sensitivity for mechanoelectrical transduction, hair cells adapt to prol

114 d the loss of stereocilia, maintained normal mechanoelectrical transduction, preserved inner hair cel

115 Mechanoelectrical transduction, the conversion of mechan

116 tle is known about the proteins that mediate mechanoelectrical transduction, the process by which aco

117 mics may arise at multiple stages, including mechanoelectrical transduction, voltage-gated channels i

118 Because cells so treated lost mechanoelectrical transduction, we attribute the reducti

119 a correlate of this behavior at the level of mechanoelectrical transduction, we examined the response

120 e hair bundle, the organelle responsible for mechanoelectrical transduction, we localized and quantif

121 mine rapid mechanical events associated with mechanoelectrical transduction, we stimulated individual

122 ate it as the mediator of slow adaptation of mechanoelectrical transduction, which is required for ba

123 identify the molecular machinery underlying mechanoelectrical transduction, Zhao et al. (2014) in th

124 and function of inner hair cells, including mechanoelectrical transduction.

125 strated defects of hair bundle structure and mechanoelectrical transduction.

126 ike structure, which is essential for normal mechanoelectrical transduction.

127 ion products despite the persistence of some mechanoelectrical transduction.

128 cochlear hair cells is the site of auditory mechanoelectrical transduction.

129 ate the role of the corresponding protein in mechanoelectrical transduction.

130 an essential role in adaptation of hair-cell mechanoelectrical transduction.

131 , ranging from whole body sodium handling to mechanoelectrical transduction.

132 bundle serves to enhance the sensitivity of mechanoelectrical transduction.

133 OHBs rely on gating springs to open mechanoelectrical-transduction (MET) ion channels, throu

134 The mechanoelectrical-transduction channel of the hair cell

135 ich amplification stems from the activity of mechanoelectrical-transduction channels.

136 ate the tectorial membrane's key role in the mechanoelectrical transformation by the inner ear, direc