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1 (pathogens) but also internal signals (i.e., mechanosensing).
2 esion, endo/exocytosis, cellular uptake, and mechanosensing.
3 ludes subcellular components responsible for mechanosensing.
4 response in hMSCs with pathological nuclear mechanosensing.
5 ult that has broad implications for cellular mechanosensing.
6 (FN), which are believed to control cellular mechanosensing.
7 ganelle dedicated to signal transduction and mechanosensing.
8 n function and constrain models for cellular mechanosensing.
9 derstood as it applies to cell mechanics and mechanosensing.
10 s a critical modulator of cell migration and mechanosensing.
11 in simulations support its proposed role in mechanosensing.
12 tion in the context of cellular adhesion and mechanosensing.
13 focal adhesions, such as talin, can exhibit mechanosensing.
14 regulatory mechanisms, proline switches and mechanosensing.
15 lin dimer orientations constitutes a mode of mechanosensing.
16 tracellular matrix (ECM) in a process termed mechanosensing.
17 gionally modified by, and contribute to, ECM mechanosensing.
18 ting cell migration, adhesive signaling, and mechanosensing.
19 e for cytokinesis, all are required for full mechanosensing.
20 inase plays a mechanistic role in neutrophil mechanosensing.
21 steps are well poised to facilitate cellular mechanosensing.
22 by reacting molecules, crack propagation and mechanosensing.
23 arthritis displays similar defective nuclear mechanosensing.
24 processes including migration, adhesion, and mechanosensing.
25 trix to control cell adhesion, migration and mechanosensing.
26 dhesions is important for cell migration and mechanosensing.
27 to which cells retain cumulative effects of mechanosensing.
28 o the cell edge, where it facilitates proper mechanosensing.
29 romised elastic fiber integrity and cellular mechanosensing.
30 on pathways based upon cumulative effects of mechanosensing.
31 ing mechanisms conferring robust linkage and mechanosensing.
32 compromise both elastic fiber integrity and mechanosensing.
33 sly proposed local and global models of cell mechanosensing.
34 the mechanical load through a process termed mechanosensing.
35 phorylation), and another in vertebrates, by mechanosensing.
36 ia can elastically withstand liquid flow for mechanosensing.
37 FAs, which promotes cell-matrix adhesion and mechanosensing.
38 ose a mechanism of PD closure as a result of mechanosensing.
39 g is a kinematic (force-independent) form of mechanosensing.
40 tecture that enables podosome protrusion and mechanosensing.
41 esting competing processes in overall T cell mechanosensing.
42 ligand/receptor linkage, is the site of this mechanosensing.
43 A traction oscillation to drive efficient FA mechanosensing.
44 onsiderably reduces fouling by deceiving the mechanosensing ability of mussels, deterring secretion o
46 scriptional enhanced associate domain (TEAD) mechanosensing activity and collagen contraction assays.
47 ovide new insights into the mechanism of YAP mechanosensing activity and qualify this Hippo effector
50 ciated ACAFAs as major mediators of cellular mechanosensing and a critical element of the physical pa
55 nase G (PKG) in controlling cardiac systolic mechanosensing and determined their pathophysiological r
56 of CD44, which is imposed downstream of ECM-mechanosensing and determines if cells couple or uncoupl
57 ediated actin polymerization at FAs promotes mechanosensing and durotaxis by maturing, and thus reinf
58 actin polymerization as a central aspect of mechanosensing and identify EVL as a crucial regulator o
59 oblastic leukemia 1-mediated (MKL1-mediated) mechanosensing and inhibits AC phagocytosis by MZMs.
60 mportance of the primary cilium structure in mechanosensing and lineage specification and surmise tha
61 Increased cortical tension leads to vinculin mechanosensing and maturation of functional tight juncti
62 ironment, we hypothesized that cells utilize mechanosensing and mechanical feedback to sense and corr
63 are more important in terms of dysfunctional mechanosensing and mechanoregulation of matrix than in v
64 diseases result, in part, from dysfunctional mechanosensing and mechanoregulation of the extracellula
69 support a key role for sdc-1 in endothelial mechanosensing and regulation of endothelial phenotype.
71 n to the extracellular matrix (ECM) mediates mechanosensing and signaling in response to altered micr
72 istic effect of YAP/TAZ activity between the mechanosensing and the Hippo pathways can be explained b
73 nctions are well-established contributors to mechanosensing and transduction machinery; however, the
74 ium, each cell division is associated with a mechanosensing and transmission event that controls MyoI
76 X, which may possibly contribute to platelet mechanosensing and/or shear resistance of VWF-platelet i
77 sults in rapid stellate spreading, assembly, mechanosensing, and differentiation of encapsulated stem
79 fening of F-actin networks, partner binding, mechanosensing, and mechanoprotection properties of FLNa
80 n has been divided into mechanotransmission, mechanosensing, and mechanoresponse, although how a cell
85 ular phenotypes and implicate alterations in mechanosensing as an important factor in the development
86 and adapt to extracellular mechanical cues (mechanosensing), as well as suppresses force-mediated ex
87 e of force application (loading rate) drives mechanosensing, as predicted by a molecular clutch model
88 addition, we identify a role for vinculin in mechanosensing, as vinculin-deficient neutrophils exhibi
89 namics, as well as mitophagy, is affected by mechanosensing at the transcriptional level, and muscle
90 vity of GPIbalpha-integrin alpha(IIb)beta(3) mechanosensing axis as a molecular mechanism that contri
93 sin-II activity then drives recruitment of a mechanosensing bridge, enabling cytoskeletal force trans
96 e investigate how this heterogeneity impacts mechanosensing by modelling the cell as an idealized loc
100 However, endowing synthetic materials with mechanosensing capabilities comparable to biological lev
101 bors, but the ability to engineer customized mechanosensing capabilities has remained a synthetic and
104 segregation, gene expression, cell division, mechanosensing, cell adhesion and biofilm formation.
109 hat Merlin is a component of cell junctional mechanosensing complexes and defines a specific set of p
111 ollectively, our results reveal that nuclear mechanosensing controls hMSC osteogenic potential mediat
112 ent study provides the first indication that mechanosensing could be modified pharmacologically durin
113 arious tissues, much less is known about how mechanosensing could regulate adult stem cells and tissu
114 of force transfer to the nucleus through the mechanosensing cytoskeletal machinery in the regulation
119 tomyosin bundles are key force-producing and mechanosensing elements in muscle and non-muscle tissues
121 strate viscous energy dissipation attenuates mechanosensing even when cells are exposed to higher eff
123 ons, specifically at the distal terminals of mechanosensing fibres innervating the skin and colon.
124 to assess intraspecific variability in plant mechanosensing, flower quality, and yield to quantify th
125 ial, we cover the development of hydrophobic mechanosensing fluorescent probes called Flippers, whose
128 plant hormone ethylene requires two signals: mechanosensing for spatial resolution and ROS for cell d
130 nsure robust left and right determination by mechanosensing, given the large spatial variability of t
135 cardiovascular disease, studying endothelial mechanosensing holds great promise for advancing our und
138 oretical framework to estimate the limits of mechanosensing in a biopolymer network, a sensory proces
139 how that integrins play an important role in mechanosensing in addition to their involvement in cell
140 that primary cilia play a role in mediating mechanosensing in bone cells through an unknown mechanis
141 sical cues, but molecular mechanisms of such mechanosensing in cell migration are not established.
142 m for how actin modularity drives invadosome mechanosensing in cells that breach tissue boundaries.
143 ndings implicate Vinculin-dependent cadherin mechanosensing in endothelial processes such as leukocyt
145 tostiffening hydrogels to manipulate nuclear mechanosensing in human mesenchymal stem cells (hMSCs) i
148 ss multiple scales that inhibition of matrix mechanosensing in persistently activated cardiac fibrobl
153 ndicating a central role for TRPV4-dependent mechanosensing in trabecular outflow, HC-067047 doubled
154 Here, we describe a second mode of talin mechanosensing in which the talin dimer itself can adopt
155 We previously described one mode of talin mechanosensing in which the vinculin-binding site of tal
156 e, we discuss a different mechanism based on mechanosensing, in which the interaction between biochem
157 nd to the nuclear envelope are important for mechanosensing, including activation of the Yes-associat
159 1 is an important player in endothelial cell mechanosensing, insights that have important implication
162 model includes three key mechanotransducers: mechanosensing ion channels, integrins, and G protein-co
166 In general, aberrant extracellular matrix mechanosensing is associated with numerous conditions, i
168 faces, this report further demonstrates that mechanosensing is more strongly associated with CD3 rath
170 This observation clearly suggests that cell mechanosensing is not mediated only by the stiffness of
172 of extracellular matrix, generally known as mechanosensing, is generally depicted as a consequence o
173 easing loading rates trigger talin-dependent mechanosensing, leading to adhesion growth and reinforce
179 mechanical cues to interfering with cellular mechanosensing machinery, to aid in controlling cell and
180 derably stimulated the expression of various mechanosensing markers of the cells, such as focal adhes
182 hese results demonstrate how tension-related mechanosensing may provide an alternative (and potential
183 direct force-activated F-actin binding as a mechanosensing mechanism by which cytoskeletal tension c
184 d provide important details of a novel early mechanosensing mechanism in bone and advances our unders
186 rmation of the cell membrane, the underlying mechanosensing mechanism inside RBCs is still controvers
187 ther than anti-CD3epsilon, consistent with a mechanosensing mechanism involving receptor deformation.
189 ell-cell contacts, we propose an alternative mechanosensing mechanism that coordinates actomyosin dyn
190 sponse to substrate stiffness may serve as a mechanosensing mechanism whereby cells use pericellular
191 yonic cell sorting and suggesting a putative mechanosensing mechanism, the physical differences point
192 es are summarized with emphasis on potential mechanosensing mechanisms and the relationship between m
193 iable molecular explanations for decoupling: mechanosensing mechanisms are responsible for competitio
194 iseases, prompting efforts to elucidate cell mechanosensing mechanisms at the molecular and cellular
195 be highly mechanosensitive, and a number of mechanosensing mechanisms have been proposed as mediator
201 anisms they form) is the result of cycles of mechanosensing, mechanotransduction, and mechanoresponse
202 contributes to compliance and dimensionality mechanosensing-mediated regulation of MT growth dynamics
203 Despite recent findings suggesting that mechanosensing might be central to this process, the rel
204 cellular functions related to communication, mechanosensing, migration, growth, and tissue deposition
205 es are thought to be detected by specialized mechanosensing molecules linked to the cytoskeleton, an
208 ned our knowledge of other topics (e.g. cell mechanosensing, motility, and bacterial aging), while op
210 hypothesized that ER plays a central role in mechanosensing of atherosusceptible shear stress (SS) by
214 ighly homogeneous MSC (iMSC) lines, cellular mechanosensing of iMSCs on engineered materials with def
216 ng evidence that the temperature sensing and mechanosensing of MSCs are interconnected via intracellu
219 independently facilitate focal adhesion and mechanosensing of stem cells, which are collectively eff
220 g: outside-in mechanical signalling, such as mechanosensing of substrate properties or shear stresses
222 six bacterial species as models of flagellar mechanosensing of surfaces to understand the current sta
224 response of this tissue, as a consequence of mechanosensing of the increase in embryonic growth poten
226 re we show the role of this crosstalk in the mechanosensing of viscosity using supported lipid bilaye
227 el, we find that myosin inhibition can boost mechanosensing on cells cultured on dissipative matrices
228 integrin-mediated cell spreading and provide mechanosensing on different extracellular matrix conditi
229 ooth muscle contractility, and dysfunctional mechanosensing or mechanoregulation of extracellular mat
233 ported that connexin (Cx) 43 hemichannels in mechanosensing osteocytes mediate the release of prostag
234 iated focal adhesions (ACAFAs) dominate cell mechanosensing over a wide range of matrix stiffness, an
236 s designed to validate the importance of FAK mechanosensing, p38, and MMP9 secretion in human cells.
238 activator with PDZ-binding domain (YAP/TAZ) mechanosensing pathway, all validated by different techn
239 (MKL1) transcriptional coactivator-mediated mechanosensing pathway, which was maintained by MZ B cel
240 othelium, therapies targeting flow-dependent mechanosensing pathways in the vasculature are unavailab
242 nsduction mechanisms with an emphasis on the mechanosensing pathways involved in creating these signa
243 eomics data, which indicate that some of the mechanosensing pathways relaying signals from the collag
249 ults provide important new insights into the mechanosensing properties of alphaT-catenin and how alph
250 ia associated mutations of the structure and mechanosensing properties of Filamin were studied by com
254 highlight the underappreciated diversity of mechanosensing properties within the myosin superfamily.
255 ery small backbone elongation, implying that mechanosensing-proposed in vertebrate muscle-is not of p
256 ce, which we propose as a mechanism by which mechanosensing proteins could respond accurately to forc
258 a puncta, active phosphorylated forms of the mechanosensing proteins p130Cas (Cas) and focal adhesion
263 study using human TM cells, we identify the mechanosensing role of the transcription factors sterol
264 upted by strategies that maintain or enhance mechanosensing signaling in the MZM barrier to prevent f
265 aginated plasma membrane domains involved in mechanosensing, signaling, endocytosis, and membrane hom
267 pressure seem likely to require cytoskeletal mechanosensing, Src, phosphatidylinositol 3-kinase, foca
268 scaffold that receives and transmits complex mechanosensing stimuli that regulate normal physiologica
272 nced during cell spreading and ECM stiffness mechanosensing, suggesting upregulation of this pathway
273 of the type IV pili family, are crucial for mechanosensing, surface adherence, bacteriophage (phage)
275 rticle discusses the different mechanisms of mechanosensing that have been proposed and reviews the l
276 e mechanism associated with impaired cardiac mechanosensing that leads to heart failure by examining
277 mponent of the EC glycocalyx participates in mechanosensing that mediates NO production in response t
282 o collisions at a venous shear rate; and 4), mechanosensing through neutrophil beta(2)-integrin/adhes
283 racellular matrix and are thought to mediate mechanosensing through the cytoskeleton-integrin-ECM lin
284 y demonstrates the implication of cell-scale mechanosensing through the internal stress within the ac
286 approaches to synthesize microparticles for mechanosensing, tissue engineering, drug delivery, energ
288 d the involvement of microtubules in linking mechanosensing to endothelial cell branching morphogenes
289 l-ECM and cell-cell adhesions participate in mechanosensing to transduce mechanical cues into biochem
290 nment through chemosensing, osmosensing, and mechanosensing using receptors and ion channels in the c
291 l an important role for paxillin in adhesion mechanosensing via myosin II-mediated FAK phosphorylatio
292 G-protein coupled receptor ADGRE2 or EMR2 in mechanosensing was revealed by the finding of a missense
293 s modulated by myosin II-mediated compliance mechanosensing when cells are cultured on two-dimensiona
294 and residual strain; this leads to aberrant mechanosensing, which in turn promotes disease progressi
295 ating the barrier permeability, and ensuring mechanosensing, which is essential to nitric oxide produ
296 w some of the emerging mechanisms of nuclear mechanosensing, which range from changes in protein conf
297 erase 5A inhibition also normalized abnormal mechanosensing while blunting progressive chamber hypert
298 ene-transformed fibroblasts are defective in mechanosensing while generating similar traction forces
300 macroscopic pressure-dependent, endothelial mechanosensing without the need for a conventional mecha