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1 er mechanical stress (i.e. cbEGF domains are mechanosensitive).
2 lly, we find that Satb1-DNA interactions are mechanosensitive.
3 network, revealing that these junctions are mechanosensitive.
4 ckles, as defined by NEAT1 localization, are mechanosensitive.
5 steps in T cell receptor triggering are not mechanosensitive.
6 sion zones, both of which are, in principle, mechanosensitive.
8 cal theory behind how these proteins display mechanosensitive accumulation has allowed us to predict
9 y, this dermal cell aggregation triggers the mechanosensitive activation of beta-catenin in adjacent
10 nvironment interaction models to reveal that mechanosensitive adhesions are necessary to reproduce th
12 sults, we propose that the kindlin2 dimer is mechanosensitive and can strengthen integrin-mediated fo
14 sin II receptor type 1 (AT1 R) is inherently mechanosensitive and initiates this signalling pathway.
15 sitive, itch sensitive, type C low-threshold mechanosensitive and nociceptive neurons with markedly d
16 es of LSECs and knockout mice, we identified mechanosensitive angiocrine signals released by LSECs wh
19 , and that cholangiocytes in the device were mechanosensitive (as demonstrated by changes in calcium
20 vestigated whether pannexins, which can form mechanosensitive ATP-permeable channels, are present in
24 ging to evaluate the effect of osteocytes, a mechanosensitive bone cell, on the migratory behavior of
25 avior in response to transient activation of mechanosensitive bristle neurons and sweet-sensing chemo
27 er, Ca(2+) influx at the plasma membrane via mechanosensitive Ca(2+) permeable channels is only media
28 potential vanilloid 4 (TRPV4) ion channel, a mechanosensitive Ca(2+)-permeable channel, may regulate
29 channels function as a critical component of mechanosensitive, Ca(2+)-signaling machinery within the
33 O1 has recently been identified as a crucial mechanosensitive cation channel in multiple solid tumour
34 tial vanilloid 4 (TRPV4), a Ca(2+)-permeable mechanosensitive cation channel in the transient recepto
35 Here, we have shown that the endothelial mechanosensitive cation channel PIEZO1 is required for f
36 d functional analyses localized the putative mechanosensitive cation channel TRPV4 to the plasma memb
37 erstand the molecular mechanism by which the mechanosensitive cation channel, transient receptor pote
40 l cells that possess many of the features of mechanosensitive cells and mediate important defense and
45 in alternating magnetic fields can activate mechanosensitive cellular functions or physically destru
46 mechanistic perspectives through which many mechanosensitive cellular processes could be quantitativ
47 ein beta-arrestin have been shown to mediate mechanosensitive cellular signaling, we tested the hypot
50 discuss some future direction on repurposing mechanosensitive channel for mechanical actuation of spa
52 entify nano-pockets on the large conductance mechanosensitive channel MscL, the high-pressure thresho
57 es previous reports of sequence coverage for mechanosensitive channel of large conductance (MscL).
58 model mechanosensitive channel protein, the mechanosensitive channel of large conductance, during ce
63 r interaction between phospholipase A2 and a mechanosensitive channel present in the internal membran
64 he folding and overall production of a model mechanosensitive channel protein, the mechanosensitive c
70 ew insights into the quantitative biology of mechanosensitive channels and emphasizes the need for ca
72 g with surprising insights into well-studied mechanosensitive channels have driven further developmen
73 s provide a precedent for the involvement of mechanosensitive channels in axon regeneration and add a
74 nce suggests that insulin modulates putative mechanosensitive channels in the dorsal root ganglion (D
75 nce suggests that insulin modulates putative mechanosensitive channels in the dorsal root ganglion ne
79 s, delineate a structural mechanism by which mechanosensitive channels open under increased membrane
83 iron oxide magnetite (Fe3O4) are coupled to mechanosensitive channels that elicit neuronal activity
84 s, TRPA1 and TRPV4 are emerging as candidate mechanosensitive channels that play a pivotal role in in
86 Although MscL is one of the best studied mechanosensitive channels, no chemical that influenced b
92 Furthermore, we found that the neurite is a mechanosensitive compartment that becomes softer and ado
93 ire of behaviors, including light avoidance, mechanosensitive contraction, food selection, and even t
94 ess three potential activating mechanisms at mechanosensitive crosslinks as inputs to a mixture model
95 on by drugs or molecular knockdown decreases mechanosensitive currents, serotonin release and downstr
96 These two stimuli are detected by distinct mechanosensitive DEG/ENaC/ASIC channels, which trigger d
97 b)beta(3) to SLC44A2 on neutrophils leads to mechanosensitive-dependent production of highly prothrom
98 e this system by showing that it can support mechanosensitive differentiation of mesenchymal stem cel
101 g under fluid shear induces unfolding of the mechanosensitive domain in GPIb-IX, which may possibly c
103 that most large-diameter proprioceptive and mechanosensitive DRG neurons expressed maternal Ube3a an
104 amics can be explained neither by the purely mechanosensitive dynamics (to breathing clean air) nor b
105 chanism of signaling that may quickly couple mechanosensitive elements in crowded biological membrane
109 known as P21-activated kinase (PAK), and the mechanosensitive factor, Yes-associated protein 1 (YAP-1
112 ograde flow and myosin II to the ECM through mechanosensitive focal adhesion proteins that are collec
114 MscL, opens a wide pore, which accounts for mechanosensitive gating due to in-plane area expansion.
116 therosclerosis by altering the expression of mechanosensitive genes in the arterial endothelium.
121 air cell is mediated by displacements of its mechanosensitive hair bundle which protrudes from the ap
122 maintaining the structural integrity of the mechanosensitive hair bundles formed by the stereocilia.
123 ere we investigate the potential to generate mechanosensitive hair cells from mouse embryonic stem ce
125 capacity to activate YAP, an effector in the mechanosensitive Hippo pathway, correlates with regenera
127 her, TRPV4's modulation of the LPS signal is mechanosensitive in that both upstream activation of p38
128 that dental neurons are capable of providing mechanosensitive information to drive rapid behavioral r
129 tween matrix and cells induces expression of mechanosensitive integrins that drive fibroblast activat
132 lular matrix and cell adhesion molecules, to mechanosensitive intracellular structures that regulate
133 ssure-induced secretion was inhibited by the mechanosensitive ion channel antagonists gadolinium, rut
134 These results demonstrate that Piezo1 is a mechanosensitive ion channel by which osteoblast lineage
136 w demonstrates a critical role of the Piezo1 mechanosensitive ion channel in guiding vascular tip cel
137 a synthetic small molecule that activates a mechanosensitive ion channel involved in a blood disorde
139 es the translation of mechanical energy into mechanosensitive ion channel opening, thereby generating
141 Recently, gain-of-function mutations in the mechanosensitive ion channel PIEZO1 were shown to amelio
145 study, we show, for the first time, that the mechanosensitive ion channel Piezo2 is specifically expr
146 esults of the present study suggest that the mechanosensitive ion channel Piezo2 is specifically expr
147 bowel GI epithelium selectively express the mechanosensitive ion channel Piezo2, and also that activ
151 nt receptor potential vanilloid 4 (TRPV4), a mechanosensitive ion channel, has been implicated in car
152 the present study we determine the role of a mechanosensitive ion channel, transient receptor potenti
153 small interfering RNA (siRNA) knockdown of a mechanosensitive ion channel, transient receptor potenti
154 nt receptor potential vanilloid 4 (TRPV4), a mechanosensitive ion channel/receptor, is required for F
155 ypothesis, we expressed potassium and sodium mechanosensitive ion channels (channels of the two-pore-
156 heterochromatin levels through activation of mechanosensitive ion channels (MSCs), without large-scal
157 e transfer across the skin and activation of mechanosensitive ion channels along the somatosensory ne
158 ing of the extracellular environment through mechanosensitive ion channels and consequent changes to
159 y of extracellular calcium due to opening of mechanosensitive ion channels and initiates a wave that
164 may mediate cellular discharge by activating mechanosensitive ion channels embedded within cellular m
166 h poration sites for fast ICWs or opening of mechanosensitive ion channels for slow ICWs, which then
168 ortance of this function, the involvement of mechanosensitive ion channels in human disease is poorly
169 suggest a previously unappreciated role for mechanosensitive ion channels in myelin development.
171 owth, it is important to investigate whether mechanosensitive ion channels may regulate axon regenera
172 nd illustrate the mechanisms that eukaryotic mechanosensitive ion channels may use to detect and fine
173 w that loss of MSL1, a member of a family of mechanosensitive ion channels related to the bacterial c
178 h-throughput suction-flow device for probing mechanosensitive ion channels(24) by back-calculating th
179 heart, gut) is mediated by biosensors (like mechanosensitive ion channels), which convert mechanical
180 n principle in the gating cycle of unrelated mechanosensitive ion channels, allowing the coupling of
181 lular constituents, including gap junctions, mechanosensitive ion channels, energy-consuming ion pump
182 ing that local tissue stiffness, read out by mechanosensitive ion channels, is critically involved in
183 nsory hair cells in the cochlea, by means of mechanosensitive ion channels, the mechano-electrical tr
184 heterochromatin levels through activation of mechanosensitive ion channels, without large-scale cell
185 years, the identification of new families of mechanosensitive ion channels-such as PIEZO and OSCA/TME
193 age TRPV4 in regulating innate immunity in a mechanosensitive manner through the modulation of dual-s
194 We also examined some well-characterized mechanosensitive markers, but found that lamin A express
196 the same spindle pole, they activate another mechanosensitive mechanism to correct the monopolar atta
198 understanding of the molecular, cellular and mechanosensitive mechanisms of valve development, and hi
199 ogue MEC-2 have emerged as key components of mechanosensitive membrane protein signalling complexes.
200 for organ bud formation, demonstrating that mechanosensitive mesenchymal stem cells drive condensati
201 architecture of hair bundles, the arrays of mechanosensitive microvilli-like stereocilia crowning th
202 correlated with applied force, supporting a mechanosensitive model in which forces stabilize vinculi
203 rved repeatedly in the beta-glomerulus only, mechanosensitive modulation of mitral cells and their po
204 main was proposed to constitute an intrinsic mechanosensitive module based on expression of a chimera
206 ha6-integrin is a matrix stiffness-regulated mechanosensitive molecule which confers an invasive fibr
210 ion in interciliary tip links, and anomalous mechanosensitive (MS) channels on the top surface of the
213 which is compelling for the investigation of mechanosensitive (MS) ion channels, since they are highl
215 by continued regulation through the acutely mechanosensitive myocardin-related transcription factor-
216 This study unveils the self-organizing and mechanosensitive nature of human amniogenesis and establ
217 ry neurons, meaning that the distribution of mechanosensitive nerve endings can be inferred by visual
218 orted mode of platelet-neutrophil crosstalk, mechanosensitive NET production, and provide mechanistic
221 of a tissue-stretching device, we uncover a mechanosensitive pathway that regulates tissue responses
224 ar cells and immune cells, activated through mechanosensitive pathways or neurohumoral mediators may
225 tion of myocyte and non-myocyte responses to mechanosensitive pathways, which can alter gene expressi
229 a-rich structure-function study on mammalian mechanosensitive Piezo channels reveals a modular protei
233 This effect is observed at the level of mechanosensitive Piezo2 channels and can be replicated i
234 clearly indicated that Merkel cells and the mechanosensitive piezo2 ion channel play critical roles
236 al spreading depression-evoked activation of mechanosensitive primary afferent meningeal nociceptors
237 of substrate physical properties on distinct mechanosensitive processes and provide a premise to reco
239 ross-linkers such as alpha-actinin-4 exhibit mechanosensitive properties in their binding dynamics to
244 Mechanical signals regulate functions of mechanosensitive proteins by inducing structural changes
245 force allosterically alters the functions of mechanosensitive proteins within adhesions to elicit bio
247 e regulated by clustering of the endothelial mechanosensitive receptor intercellular adhesion molecul
248 patial and mechanical properties of targeted mechanosensitive receptors in live cells by adjusting th
250 cell through E-cadherin adhesions elicits a mechanosensitive response in neighbor cells that is nece
251 ge correlation spectroscopy, we measured the mechanosensitive response of integrin mobility at the wh
252 stimulation and data acquisition to capture mechanosensitive responses and suggest that mechanical c
254 ogether, during bladder filling, the bladder mechanosensitive SAAs of Adelta-fibers were attenuated,
255 ere disruption of ordered lipids initiates a mechanosensitive signal for cell growth through mechanic
257 iated immunosuppressive pathways, as well as mechanosensitive signaling cascades that are activated b
258 actile unit of striated muscle and also as a mechanosensitive signaling molecule during cell migratio
259 A-sequencing of LSECs identified proteins in mechanosensitive signaling pathways that are altered in
260 ates actomyosin contractility and downstream mechanosensitive signaling to profoundly alter the tumor
262 investigated the characteristics of bladder mechanosensitive single-unit afferent activities (SAAs)
268 dles possess tip links that interconnect the mechanosensitive stereocilia and convey force to the tra
270 tein complex at the ankle link region of the mechanosensitive stereociliary bundle in hair cells.
271 d waves into electrical signals depends upon mechanosensitive stereociliary bundles that project from
273 for dynamic protein-protein interactions in mechanosensitive structures, such as focal adhesions, in
274 hese needs, we developed the first mammalian mechanosensitive synthetic gene network to monitor endot
275 es use tyrosine kinase signalling to build a mechanosensitive, talin- and vinculin-mediated, focal ad
277 ory and biophysical experiments to show that mechanosensitive tension remodeling of epithelial cell j
278 rts that the insulin production of islets is mechanosensitive, these findings open up an exciting new
283 thophysiology via differential regulation of mechanosensitive transcription factors (MSTFs) (KLF2, KL
285 wn of TRPV4 enhanced nuclear localization of mechanosensitive transcription factors, yes-associated p
288 in alpha6beta4 regulates the activity of the mechanosensitive transcriptional regulator YAP through i
289 ce exclusion method, we demonstrate that the mechanosensitive transcriptional regulators YAP (Yes-ass
294 at TREK-1 and TRAAK, the thermosensitive and mechanosensitive two-pore-domain potassium (K2P) channel
295 r of formerly 'silent' afferents that became mechanosensitive was increased five fold when the skin w
296 Because P2X4 channels are not intrinsically mechanosensitive, we investigated whether podocytes rele
299 ithelial plasticity, fibrogenic activity and mechanosensitive Yap/Taz transcriptional activation.
300 e protein level and nuclear translocation of mechanosensitive Yes-associated protein 1 (YAP1), which