ライフサイエンスコーパス: mechanosensitivity

1 broadly classified into two groups based on mechanosensitivity.

2 ve E4 stiffness, highlighting cell-intrinsic mechanosensitivity.

3 er they exhibit circadian variation in their mechanosensitivity.

4 re probably the result of altered peripheral mechanosensitivity.

5 s require kinocilia and kinocilial links for mechanosensitivity.

6 ed lidocaine analog (QX-314) failed to block mechanosensitivity.

7 is so essential for cell form, motility and mechanosensitivity.

8 ole of subunit composition in observed NMDAR mechanosensitivity.

9 pr signaling is a negative modulator of bone mechanosensitivity.

10 us to gain additional insights into the cell mechanosensitivity.

11 common sequence 'signature' that identifies mechanosensitivity.

12 coincides developmentally with the onset of mechanosensitivity.

13 ter) might exert their effect by influencing mechanosensitivity.

14 cted against either region result in loss of mechanosensitivity.

15 lope stiffness at the heart of its region of mechanosensitivity.

16 s to hypotheses on the nature of the channel mechanosensitivity.

17 orting the hypothesis of natural killer cell mechanosensitivity.

18 teria differ in kinetics and their degree of mechanosensitivity.

19 ts native mechanosensitivity or even acquire mechanosensitivity.

20 d or substituted, affect channel kinetics or mechanosensitivity.

21 n the membrane and the channel that mediates mechanosensitivity.

22 nist) also attenuated colonic afferent nerve mechanosensitivity.

23 nel from Bacillus halodurans, to investigate mechanosensitivity.

24 n while monitoring the impact on single-cell mechanosensitivity.

25 r mediating calcium signaling and may affect mechanosensitivity.

26 timulator assessed changes in the afferent's mechanosensitivity.

27 sner corpuscles which may have increased the mechanosensitivity.

28 adding up to high significance, and focused mechanosensitivity.

29 umor vessel maturation via modulation of TEC mechanosensitivity.

30 ein (MLP ratio) is associated with a loss of mechanosensitivity.

31 irculating level and is able to modulate GVA mechanosensitivity.

32 erexcitability of A-fibre axons and enhanced mechanosensitivity.

33 e ankyrin-CIB subcomplex is required for TMC mechanosensitivity.

34 during development: exactly at the onset of mechanosensitivity.

35 ircadian variation in stomach content or GVA mechanosensitivity.

36 se to electrical pacing, suggesting impaired mechanosensitivity.

37 ghts into how viscoelastic properties affect mechanosensitivity.

38 s a rapid noninvasive whole-cell reporter of mechanosensitivity.

39 expressed just before or after maturation of mechanosensitivity.

40 needed to "really swim," i.e., achieve high mechanosensitivity.

41 clarify their physiological role in bladder mechanosensitivity.

42 mily members do not directly affect cellular mechanosensitivity; 2) there are residual manifestations

43 One of the explanations for mechanosensitivity, a lipid-bilayer model, suggests that

44 develop a self-consistent physical model for mechanosensitivity, a process by which a cell detects th

45 llecting lymphatics adapt their function and mechanosensitivity after a contralateral injury, switchi

46 hat were mechanically insensitive and gained mechanosensitivity after IS exposure were rare.

47 onse (P = 0.92, n = 14), and maintained this mechanosensitivity after luminal anaesthesia.

48 We map mechanosensitivity along the lateral line using imaging

49 reveals a biophysical explanation for TRAAK mechanosensitivity--an expansion in cross-sectional area

50 ol recordings but differ in terms of reduced mechanosensitivity and adaptation to sustained stimulati

51 sensor, and Coulter counter assays to study mechanosensitivity and adhesion of E and R cells.

52 tor (Lepr) signaling in determining the bone mechanosensitivity and also evaluated whether difference

53 sensitization of afferent pathways mediating mechanosensitivity and chemosensitivity.

54 5A-syntrophin gamma 2 interaction determines mechanosensitivity and current availability.

55 Therefore, Piezo2 is critical to EC cell mechanosensitivity and downstream physiological effects.

56 s combination also attenuated afferent nerve mechanosensitivity and DRG neuron excitability, which wa

57 on determines the composition, organization, mechanosensitivity and dynamics of these adhesions.

58 ally challenging owing to the deep location, mechanosensitivity and fluid-filled, bone-encased nature

59 reate planarizable push-pull probes with the mechanosensitivity and fluorescence lifetime needed for

60 bout how membrane lipids may influence their mechanosensitivity and function.

61 tivity filter that may have implications for mechanosensitivity and gating of TRAAK channels.

62 adigms emerging for bilayer-mediated channel mechanosensitivity and how this molecular detail may pro

63 amined the role of P2X(3) receptors in colon mechanosensitivity and intracolonic zymosan-produced hyp

64 These results show how the mechanosensitivity and mechanics of single cells can be

65 ract in response to stretch, suggesting that mechanosensitivity and mechanotransduction can occur at

66 ins localize to lysosomes, mediate lysosomal mechanosensitivity and modulate lysosomal morphology and

67 genes of Caenorhabditis elegans involved in mechanosensitivity and neuronal degeneration.

68 ociceptors powerfully contribute to visceral mechanosensitivity and nociception under physiological c

69 vity by dampening stretch-sensitive afferent mechanosensitivity and normalizing afferent sensitizatio

70 e also found longitudinal differences in the mechanosensitivity and physiological properties of RB ne

71 mechanochromic polymers, which enhances the mechanosensitivity and stretchability of mechanochromic

72 each recurved bristle are essential for its mechanosensitivity and the kicking behavior.

73 r evidence of Ca2+ influx and determined its mechanosensitivity and voltage dependence.

74 -1 clusters is impaired, then TJs lose their mechanosensitivity, and consequently, EVL-YSL movement i

75 Hair bundles mediate mechanosensitivity, and their highly organized structure

76 adian fluctuations in gastric vagal afferent mechanosensitivity are lost.

77 of cells, but the mechanisms underlying the mechanosensitivity are not clearly understood.

78 After incorporating actomyosin mechanosensitivity, Arp2/3 network growth locally induce

79 onship between action potential duration and mechanosensitivity as has been observed in vivo.

80 ata indicate for the first time that myocyte mechanosensitivity as indicated by the MLP ratio is regu

81 We find that HCT-8 cells lose mechanosensitivity as they undergo E-to-R transition.

82 Myocyte mechanosensitivity, as indicated by the muscle LIM prote

83 r fundamental understanding of how lymphatic mechanosensitivity assists the coordination of lymphatic

84 e, we demonstrate that Wnt signaling affects mechanosensitivity at both cellular and tissue levels to

85 ut also explains observed differences in the mechanosensitivity between the three investigated mice.

86 alysis revealed that R616Q channels maintain mechanosensitivity but have greater constitutive activit

87 Mice lacking SLC45A4 show normal mechanosensitivity but reduced sensitivity to noxious he

88 roduced NO in cultured DRG neurons decreases mechanosensitivity by inhibiting voltage-gated Na(+) and

89 The block of Na(V)1.5 mechanosensitivity by ranolazine does not utilize the es

90 Block of Na(V)1.5 mechanosensitivity by ranolazine was not due to the know

91 etically, we show both cellular rigidity and mechanosensitivity can be restored in Atat1 deficient se

92 To examine how mechanosensitivity changes during the transition to hear

93 development, a switch to correctly polarized mechanosensitivity coincides with the formation of tip l

94 We conclude PLD2 mechanosensitivity combines with TREK-1 ion permeability

95 n sensory neurons, and show that Merkel-cell mechanosensitivity completely depends on Piezo2.

96 However, corneal mechanosensitivity decreased progressively only in wild-

97 ed distinct MSC subpopulations with distinct mechanosensitivities, differentiation capacities, and ce

98 We further show that this mechanosensitivity enhances the firing frequency of indi

99 We find that organoid hair cells acquire mechanosensitivity equivalent to functionally mature hai

100 We contrasted their mechanosensitivity, excitability and chemosensitivity in

101 myogenesis, as interface mutations affecting mechanosensitivity fail to restore the essential role of

102 utagenesis near the hinge diminished NaChBac mechanosensitivity, further supporting the proposed mech

103 However, the regulation of this mechanosensitivity has yet to be further explored.

104 Understanding mechanosensitivity (i.e., how cells sense the stiffness

105 s study demonstrates the use of AFM to study mechanosensitivity in a cell system that responds at fas

106 Furthermore, Runx1 is required to establish mechanosensitivity in C-LTMRs, by controlling the expres

107 retch, the mechanisms that underlie visceral mechanosensitivity in colon-innervating visceral afferen

108 visceromotor responses (VMR), afferent nerve mechanosensitivity in flat-sheet colon preparations, and

109 ity; 2) there are residual manifestations of mechanosensitivity in hair cells of mouse Tmc1:Tmc2 doub

110 nship between cell mechanical properties and mechanosensitivity in live cells of the dinoflagellate P

111 mportantly, mouse TMEM63A mediates lysosomal mechanosensitivity in Neuro-2a cells, indicative of func

112 In contrast, mechanosensitivity in non-vagal afferents was modulated

113 mall-fiber sensory neurons and produces less mechanosensitivity in oocytes.

114 Our studies reveal that mechanosensitivity in OSCA/TMEM63 channels is affected b

115 olecular determinant contributing to dynamic mechanosensitivity in proprioceptors.

116 oocytes and found that they possess similar mechanosensitivity in response to hypo-osmolar stress.

117 Finally, whereas the mechanosensitivity in the glomerular layer was observed

118 Mechanosensitivity in the intestine requires an intact c

119 dbcAMP also induced mechanosensitivity in the majority of MIA units (6/9, 67

120 e saw an age-associated decrease in afferent mechanosensitivity in the mouse colon affecting HT units

121 ated with attenuated high-threshold afferent mechanosensitivity in the murine colon, and associated l

122 le further assays demonstrated no observable mechanosensitivity in the tmc1/2a/2b triple mutant inner

123 rant urothelial function, increased afferent mechanosensitivity, increased smooth muscle contractilit

124 s (e.g. mitosis and apoptosis), may increase mechanosensitivity independently of the intrinsic proper

125 The enhanced mechanosensitivity induced by CCDC ex vivo and in vivo w

126 Mechanosensitivity is a well-known feature of astrocytes

127 We establish that this broad loss of mechanosensitivity is dependent upon the acetyltransfera

128 s of baroreceptor activity each suggest that mechanosensitivity is diminished in ASIC2 null mice.

129 echanosensor region demonstrate that filamin mechanosensitivity is important for the maturation of ac

130 lls, but it has yet to be tested whether the mechanosensitivity is important for their function in in

131 have obliquely oriented tip links, and their mechanosensitivity is mediated exclusively by "top-to-to

132 The absence of mechanosensitivity is not due to the vitelline membrane,

133 Mechanosensitivity is one of the essential functionaliti

134 We show that gene mechanosensitivity is preserved after LINC disruption, b

135 The demonstrated mechanosensitivity is quantitatively consistent with mem

136 ecular mechanism of TRAAK channel gating and mechanosensitivity is unknown.

137 However, the molecular mechanism driving BFM mechanosensitivity is unknown.

138 O1-deficient cells, that exhibit no baseline mechanosensitivity, is sufficient to reconstitute mechan

139 Our results suggest that mechanosensitivity may be a general feature in olfactory

140 Ranolazine block of Na(V)1.5 mechanosensitivity may be relevant in disorders of mecha

141 in a lineage dependent manner and that their mechanosensitivity may regulate the dynamics of signalin

142 al activation of TRPV4 restored aberrant TEC mechanosensitivity, migration and normalized abnormal an

143 ned and condensed the nucleus, and increased mechanosensitivity more rapidly than soluble factors.

144 Altered mechanosensitivity occurred in the absence of any change

145 ogical and pathological conditions may alter mechanosensitivity of a cell independently of the intrin

146 layer can be harnessed to control gating and mechanosensitivity of a eukaryotic ion channel.

147 ChBac is overall mechanosensitive due to the mechanosensitivity of a voltage-insensitive gating step

148 pport these predictions, suggesting that the mechanosensitivity of adhesions is an emergent property

149 contains a genetic locus that modulates the mechanosensitivity of bone tissue.

150 To date, there are very few reports on mechanosensitivity of Ca2+ channels, particularly neuron

151 Our findings provide in vivo evidence for mechanosensitivity of cell-cell junctions and imply that

152 h ellipsoid packing models revealed that the mechanosensitivity of chromosomes was correlated with th

153 , to acute ocular pain, we characterized the mechanosensitivity of corneal sensory neurons.

154 that natural variations in TRP-4 reduce the mechanosensitivity of dopaminergic neurons.

155 Our data suggests that icilin modulates the mechanosensitivity of dorsal horn neurones.

156 ty and affected the spontaneous activity and mechanosensitivity of gastrointestinal sensory nerves.

157 Although mechanosensitivity of heart rhythm has been described in

158 Herein we leveraged the mechanosensitivity of hESCs and employed, to our knowled

159 ond to ATC stimulations highlight the unique mechanosensitivity of hPSCs to integrin-targeted cyclic

160 ly imaging the structure of hair bundles and mechanosensitivity of individual lateral-line hair cells

161 skin nerve preparation studies show that the mechanosensitivity of low-threshold mechanoreceptors str

162 ction, but the consequent alterations in the mechanosensitivity of lymphatics to IPC is not known.

163 hannel, providing insights into the basis of mechanosensitivity of mechanotransduction channels.

164 ere used to test changes in the activity and mechanosensitivity of meningeal nociceptors in response

165 romoted a delayed and robust increase in the mechanosensitivity of meningeal nociceptors, with a time

166 ted currents in vitro is responsible for the mechanosensitivity of most low-threshold mechanoreceptor

167 To understand better the mechanosensitivity of Muller cells and its association w

168 The effect of ranolazine on mechanosensitivity of Na(V)1.5 was approximated by lidoc

169 Mechanosensitivity of Na(V)1.5 was tested in voltage-cla

170 Ranolazine effectively inhibits mechanosensitivity of Na(V)1.5.

171 Together, these data demonstrate the mechanosensitivity of neovascular networks and highlight

172 tivation thereby specifically increasing the mechanosensitivity of neurons.

173 duce pain hypersensitivity by increasing the mechanosensitivity of nociceptive sensory afferent.

174 These data suggest that the selective mechanosensitivity of NR2B can significantly impact neur

175 Moreover, the mechanosensitivity of parvalbumin-expressing neurons tha

176 s a mechanistic feedback system based on the mechanosensitivity of periosteal progenitor cells, which

177 romising targets for drugs that modulate the mechanosensitivity of Piezo channels.

178 The ability of GsMTx4 to target the mechanosensitivity of Piezo1 supports the use of this ch

179 lining helices are required to ensure normal mechanosensitivity of PIEZO2.

180 us these myosins, especially 2B, have marked mechanosensitivity of product release.

181 ysiological recordings demonstrated that the mechanosensitivity of recurved bristles requires Nanchun

182 Further, we show that the mechanosensitivity of several transcriptional regulators

183 plasmic transport, setting the rules for the mechanosensitivity of shuttling proteins.

184 , we used a recombinant system to assess the mechanosensitivity of specific subtypes and demonstrate

185 provides durability and rigidity for normal mechanosensitivity of stereocilia and may contribute to

186 erapeutic gene restores the architecture and mechanosensitivity of stereociliary bundles, improves he

187 in mediating changes in the dynamic range of mechanosensitivity of TFs.

188 For adaptation to set the position of mechanosensitivity of the bundle accurately, the free Ca

189 a major role in both the open dwell time and mechanosensitivity of the channel.

190 gthened instead of weakened by force) drives mechanosensitivity of the flagellar motor complex.

191 eocilia that are aligned in the direction of mechanosensitivity of the hair bundle.

192 to the Kir3.4 subunit, which reproduced the mechanosensitivity of the heteromeric channel when expre

193 By extending the model to consider the mechanosensitivity of the integrin bond, we identify mec

194 The results suggest an enhanced mechanosensitivity of the lymphatics, along with a trans

195 Mechanosensitivity of the nerve endings was quantified u

196 as additional touch sensors, LSCs potentiate mechanosensitivity of the terminal, which detects touch

197 nic tone consistent with previous reports of mechanosensitivity of this G protein-coupled receptor.

198 stin via membrane bending, demonstrating the mechanosensitivity of this unique membrane motor protein

199 essential for NOMPC mechanogating in vitro, mechanosensitivity of touch receptor neurons in vivo, an

200 Mechanosensitivity of TRAAK is mediated directly through

201 Mechanosensitivity of TRPV4 provides the simplest explan

202 Leptin potentiated mucosal receptor mechanosensitivity only in SLD mice and with reduced pot

203 ther a decrease or an increase in its native mechanosensitivity or even acquire mechanosensitivity.

204 onists did not attenuate VMR, afferent nerve mechanosensitivity, or DRG neuron excitability.

205 This shows that the loss mechanosensitivity plays an important role during the tr

206 en shown to exhibit circadian fluctuation in mechanosensitivity, potentially allowing for time of day

207 n be used to elucidate the genes involved in mechanosensitivity regulation.

208 ults provide an explanation for TREK channel mechanosensitivity, regulation by diverse stimuli, and p

209 are mechanosensitive, but the mechanisms of mechanosensitivity remain poorly understood.

210 onment, although the molecular mechanisms of mechanosensitivity remain unknown.

211 sponse to actomyosin contractility, and this mechanosensitivity requires Abl-dependent phosphorylatio

212 og, also abrogated CIPN and reduced baseline mechanosensitivity, respectively, providing independent

213 The mechanosensitivity response is selective.

214 asts of C3H (the mouse strain with poor bone mechanosensitivity) restored) their anabolic responses t

215 al forces; our work highlights how, in turn, mechanosensitivity scales with cell size.

216 f different types of lipids on MscS and MscL mechanosensitivity simultaneously using the patch-clamp

217 Moreover, the superior mechanosensitivity, SM 3.4 VPa(-1) of the FTNG enables t

218 Although integrin alpha subunit determines mechanosensitivity, the ligation between alpha subunit a

219 about intraprotein interactions that govern mechanosensitivity-the most unique feature of PIEZOs.

220 In the periphery, ATP mediates nociception, mechanosensitivity, thermal sensitivity and O2 chemosens

221 ing new insights into the basis of hair-cell mechanosensitivity; this enterprise has been joined by l

222 of OIH in an assay of colonic afferent nerve mechanosensitivity; this was inhibited by the delta-opio

223 The model shows that altering integrin mechanosensitivity threshold (MT) increases mechanotrans

224 hanically activated ion channels that confer mechanosensitivity to a variety of different cell types.

225 hetic (CCDC) TGR5 agonists enhanced afferent mechanosensitivity to bladder distension.

226 owel syndrome, yet the molecules that confer mechanosensitivity to colon sensory neurons and their co

227 demonstrates that hASC primary cilia exhibit mechanosensitivity to cyclic tensile strain and lineage-

228 In contrast, mechanosensitivity to distension and the secondary respo

229 ctility, but not much is known about how its mechanosensitivity to external pressure is affected, whi

230 erentiation and in vivo fibrosis through its mechanosensitivity to extracellular matrix stiffness.

231 SNS-gp130(-/-) mice revealed reduced mechanosensitivity to high mechanical forces in the von

232 activated ion channel PIEZO2, which confers mechanosensitivity to many nociceptors.

233 his F-actin network is also found to provide mechanosensitivity to the Cav1.3 channels when varying i

234 ive voltage-gated potassium channels confers mechanosensitivity to the chimeric channels.

235 am product of phospholipase A(2), relegating mechanosensitivity to the enzymes or their regulators.

236 ation and flow of non-junctional ZO-1 confer mechanosensitivity to TJs.

237 e (ARPKD) is poorly understood, but impaired mechanosensitivity to tubular flow and dysfunctional cal

238 Mechanosensitivity toward the extracellular matrix was i

239 function, which is correlated with aberrant mechanosensitivity towards extracellular matrix stiffnes

240 The mechanisms of mechanosensitivity underlying the response of the human

241 including nociceptors have strongly reduced mechanosensitivity upon Atat1 deletion, and that consequ

242 t is necessary and sufficient for conferring mechanosensitivity upstream of the junctional complex an

243 Collectively, these results suggest that TM mechanosensitivity utilizes kinetically, regulatory and

244 eveal that FM 1-43 is a functional probe for mechanosensitivity via PIEZO2 activation in vivo and wil

245 The regenerated population acquired mechanosensitivity, voltage-gated channels, and afferent

246 Chemosensitivity but not mechanosensitivity was correlated with reflux symptoms a

247 In females, osteocyte mechanosensitivity was decreased at small force magnitud

248 Mechanosensitivity was evaluated with a barostat using u

249 In males, osteocyte mechanosensitivity was increased in some groups and anab

250 steoblasts, indicating that the differential mechanosensitivity was intrinsic to osteoblasts.

251 Furthermore, NR2B mechanosensitivity was regulated by PKC activity, becaus

252 Na(v)1.5 was expressed in HEK 293 cells and mechanosensitivity was studied in cell-attached patches.

253 he mechanochemical basis underlying junction mechanosensitivity, we analyzed tight junction (TJ) form

254 tudies have led to models that explain their mechanosensitivity, we lack a quantitative understanding

255 orectal distension, and colon afferent fiber mechanosensitivity were assessed in control (C57BL/6) mi

256 me points, both tension and mucosal receptor mechanosensitivity were the lowest and highest, respecti

257 um signaling and high vascular smooth muscle mechanosensitivity, which could explain the onset of pre

258 156 out of 465 neurons tested (34%) showed mechanosensitivity while 55 out of 118 neurons (47%) wer

259 oncurrent decline in bone mass, quality, and mechanosensitivity with age remain unclear.

260 mphatic collecting vessel displays exquisite mechanosensitivity, with a dynamic range from <1 to >20

261 res that suggest an exaggerated intracranial mechanosensitivity (worsening of the pain by coughing, b