ライフサイエンスコーパス: mechanosensory

1 Mechanosensory activity conferred by ectopically express

2 High-threshold mechanosensory afferent fibres and small-diameter DRG ne

3 Animals depend on sensory feedback from mechanosensory afferents for the dynamic control of move

4 Mechanosensory afferents of the massive array of chordot

5 se results with previous findings on primate mechanosensory afferents suggest multiplexed population

6 nic and mesenteric nerves were used to study mechanosensory and chemosensory afferent function in 3-,

7 In chordates, mechanosensory and chemosensory neurons of the periphera

8 actile decision making can be predicted from mechanosensory and choice-memory signals, and provides a

9 neages, the development and evolution of the mechanosensory and electrosensory components of the late

10 Eel's exhibit 'sensory conflict' when mechanosensory and electrosensory cues are separated, st

11 zone (SEZ) of the Drosophila brain processes mechanosensory and gustatory sensory input from sensilla

12 tracing sGPN axons, we identify the antennal mechanosensory and motor center (AMMC) as an immediate h

13 hnston's organ, which innervate the antennal mechanosensory and motor center (AMMC) of the brain.

14 The T5 tract projects into the antennal mechanosensory and motor center (AMMC), while the T6 tra

15 mn of the anterior SEZ, creating the antenno-mechanosensory and motor center (AMMC).

16 tricted to the central complex, the antennal mechanosensory and motor center, and the protocerebrum.

17 Here we show that combining mechanosensory and nociceptive cues synergistically enha

18 that this cross-modal signaling between the mechanosensory and olfactory circuits is mediated by neu

19 for known and unknown neuron populations of mechanosensory and pain circuits in the spinal cord.

20 and humans lacking Piezo2 experience severe mechanosensory and proprioceptive deficits and fail to d

21 ns that requires the integration of parallel mechanosensory and thermosensory pathways.

22 Because the compass incorporates both mechanosensory and visual cues, it should enable navigat

23 Insect flight, for example, relies on both mechanosensory and visual pathways.

24 r green alga that is guided by photosensory, mechanosensory, and chemosensory cues.

25 The feedback from mechanosensory-and particularly, proprioceptive-organs m

26 pressure and velocity cues at the sensitive mechanosensory antennae.

27 ary hair bundles atop sensory hair cells are mechanosensory apparatus with planar polarized structure

28 teractions is essential for formation of all mechanosensory-axon branches, the local ligand-induced a

29 severe disruption of collateral formation of mechanosensory axons.

30 targeted light beams independently activate mechanosensory bristle neurons on different body parts.

31 dalities that could detect dust, we focus on mechanosensory bristle neurons, whose optogenetic activa

32 cells of the Drosophila anterior wing margin mechanosensory bristles undergo PCP-directed apical rota

33 Mechanosensory bundles on auditory sensory cells are com

34 These data suggest that mechanosensory Ca(2+) responses in astrocytes are mediat

35 e of ATP is the key central event underlying mechanosensory Ca(2+) responses in astrocytes.

36 However, the mechanosensory cells and key molecules responsible for s

37 Furthermore, distinct chemo- and mechanosensory cells exhibit specific receptor expressio

38 Since mechanosensory cells in connective tissue are surrounded

39 Osteocytes are considered to be the major mechanosensory cells of bone, but how osteocytes in vivo

40 um of lips and olfactory epithelium, and ii) mechanosensory cells of neuromasts belonging to the late

41 Hair cells are the specialized mechanosensory cells of the inner ear that capture audit

42 Hair cells are the mechanosensory cells of the inner ear.

43 lls in the mammalian cochlea are specialized mechanosensory cells that convert sound-induced vibratio

44 emen1 has a negative effect on the number of mechanosensory cells that form in the zebrafish neuromas

45 ns which affect the cochlear hair cells, the mechanosensory cells which allow for sound detection and

46 h integrins are an upstream component of the mechanosensory cellular apparatus, regulating fundamenta

47 c profiles, electrophysiological properties, mechanosensory channel expression, and vulnerability to

48 genetic activation of neurons expressing the mechanosensory channel NOMPC.

49 Abdominal neurons expressing the mechanosensory channel Piezo convey the signal of copula

50 ore, we uncovered the essential roles of the mechanosensory channel Piezo in orchestrating disseminat

51 ligase needed for the ubiquitination of the mechanosensory channel subunit MEC-4.

52 ns in the Transient Receptor Potential (TRP) mechanosensory channel trp-4, a member of the invertebra

53 tor potential vanilloid 4 (TRPV4), a ciliary mechanosensory channel, suggests that OCRL may act throu

54 Mechanosensory chordotonal neurons detect displacements

55 HC-1 functions within specialized non-motile mechanosensory cilia, where it regulates neuronal activa

56 losely mimic the intricate morphology of the mechanosensory ciliary bundles in biological hair cells.

57 nction activity between a chemosensory and a mechanosensory circuit.

58 nd on superb motor skills and the underlying mechanosensory circuits in combination with sensory orga

59 on is unavailable, indicating a short-range, mechanosensory collision-avoidance mechanism.

60 targeting Merkel-cell afferents to discrete mechanosensory compartments.

61 We demonstrate that this mechanosensory compass cue is only used when skylight cu

62 migration, in allowing PECAM-1 to serve as a mechanosensory complex in endothelial cells, in its abil

63 ted to mitochondria but colocalized with the mechanosensory complex that requires the podocin ortholo

64 VEGFR3 levels, a component of a junctional mechanosensory complex, mediate these differences.

65 ntify as another component of the junctional mechanosensory complex.

66 ll, which we show contains a high density of mechanosensory corpuscles innervated by functional rapid

67 helia and, surprisingly, short cilia form in mechanosensory cristae even in the absence of kif3a In c

68 ry cues are separated, striking first toward mechanosensory cues and later toward conductors.

69 vioral task that challenges them to use rich mechanosensory cues but can be performed using one whisk

70 ing both coupled motion, in which visual and mechanosensory cues follow the same motion trajectory, a

71 Whether larvae can anemotax in gradients of mechanosensory cues is unknown.

72 llows independent presentation of visual and mechanosensory cues.

73 and that challenges animals to use multiple mechanosensory cues.

74 gical shear stress induces unfolding of this mechanosensory domain (MSD) on the platelet surface.

75 Recently, we have discovered a juxtamembrane mechanosensory domain (MSD) within the GPIbalpha subunit

76 Specific mutation of the putative PilY1 mechanosensory domain is sufficient to induce virulence

77 Yoda1 binding pocket located in the putative mechanosensory domain, approximately 40 angstrom away fr

78 y precise tactile encoding capability of the mechanosensory dorsal horn.

79 ate GPER-mediated estrogen signalling in the mechanosensory-driven activation of HSCs and put forward

80 hway in peritumoural stromal remodelling and mechanosensory-driven activation of PSCs, and further su

81 3 in peripheral somatosensory neurons causes mechanosensory dysfunction through loss of GABAA recepto

82 lY1 and functional type IV pili are required mechanosensory elements.

83 work models representing sequential steps of mechanosensory encoding: skin displacement at touch rece

84 ons are conveyed by distinct combinations of mechanosensory end organs and the low-threshold mechanor

85 Meissner corpuscles are mechanosensory end organs that densely occupy mammalian

86 les, guard, awl/auchene and zigzag, serve as mechanosensory end organs.

87 The development of mechanosensory epithelia, such as those of the auditory

88 tion-based protrusion requires an additional mechanosensory feedback cascade that indirectly links me

89 We show that mechanosensory feedback enhances the recruitment of moto

90 Mechanosensory feedback from the digestive tract to the

91 circuit diagram enabling speed modulation by mechanosensory feedback in the vertebrate spinal cord.

92 Here we investigate how mechanosensory feedback shapes active locomotion in a ge

93 activity and that this, in turn, alters the mechanosensory feedback that regulates the wing steering

94 exes in the spinal cord, the contribution of mechanosensory feedback to active locomotion and the nat

95 est studied in Dipteran flies in which rapid mechanosensory feedback to wing motor system is provided

96 ly on limb mechanics but also on appropriate mechanosensory feedback.

97 s from the lateral ocelli include a tract of mechanosensory fibers originating in the antennae.

98 is required for stereocilia maintenance and mechanosensory function of the hair bundle.

99 Colonic and jejunal afferent mechanosensory function was attenuated with age and thes

100 Colonic age-related loss of mechanosensory function was more pronounced in high-thre

101 cular immunopathology and maintained corneal mechanosensory function.

102 with tolvaptan increases ciliary length and mechanosensory function.

103 onal organs perform proprioceptive and other mechanosensory functions in insects and crustaceans.

104 y structural, signaling, osmoregulatory, and mechanosensory functions within the retina, is mediated

105 d by two parallel groups of chemosensory and mechanosensory glutamatergic neurons that detect food-re

106 The mechanisms underlying mechanosensory hair bundle formation in auditory sensory

107 In contrast to the extensively studied mechanosensory hair bundle, the cuticular plate is not a

108 ion of specific innervation patterns between mechanosensory hair cells (HCs) and afferent spiral gang

109 Mechanosensory hair cells (HCs) are the primary receptor

110 undle (hair bundle) on the apical surface of mechanosensory hair cells (HCs) dictates the direction i

111 Mechanosensory hair cells (HCs) residing in the inner ea

112 The inner ear utricle requires mechanosensory hair cells (HCs) to detect linear acceler

113 s neuromasts - small sense organs containing mechanosensory hair cells - distributed in characteristi

114 by the cochlea relies on frequency tuning of mechanosensory hair cells along a tonotopic axis.

115 epithelium houses two major types of cells, mechanosensory hair cells and underlying supporting cell

116 Mechanosensory hair cells are vulnerable to environmenta

117 lecules or drugs that can protect or restore mechanosensory hair cells has been hampered by limited c

118 s most commonly caused by the destruction of mechanosensory hair cells in the ear.

119 Individual tones then stimulate mechanosensory hair cells located at different positions

120 vels of reactive oxygen species (ROS) within mechanosensory hair cells of the inner ear that have bee

121 Mechanosensory hair cells of the zebrafish lateral line

122 Compound 90 protects mechanosensory hair cells with HC50 of 120 nM and demons

123 killing of proximal tubule kidney cells and mechanosensory hair cells, though the mechanisms underly

124 fluorescently labeled AGs in live zebrafish mechanosensory hair cells.

125 lex sounds into tones that are transduced by mechanosensory hair cells.

126 stems, results in the precise orientation of mechanosensory hair cells.

127 utative electric field sensors: antennae and mechanosensory hairs.

128 on CHD8*chd-7 and NLGN3*nlg-1 that underlie mechanosensory hyperresponsivity and impaired habituatio

129 astrocytic GABA(B)R1/2 signaling suppressed mechanosensory-induced seizure activity in mutants with

130 how central circuits integrate and transform mechanosensory information to guide locomotion.

131 Hearing relies on the mechanosensory inner and outer hair cells (OHCs) of the

132 eveloped a mouse active touch task where the mechanosensory input can be precisely measured and that

133 We further show that neurons integrating mechanosensory input facilitate primary nociceptive outp

134 Notably, integration of mechanosensory input from innocuous and nociceptive sens

135 of hydrodynamic forces, contact forces, and mechanosensory input to the interactions among individua

136 sensory input: the lateral dendrite receives mechanosensory input while the ventral dendrite receives

137 In contrast, in the absence of mechanosensory input, FLP-20 signaling is reduced, synap

138 rlying development of MSI between visual and mechanosensory inputs in the optic tectum of Xenopus tad

139 Despite the convergence of nociceptive and mechanosensory inputs on common second-order neurons (SO

140 he subcellular segregation of the visual and mechanosensory inputs to specific regions of tectal neur

141 are governed by combined visual and antennal mechanosensory inputs.

142 Finally, pharmacological inhibition of the mechanosensory ion channel phenocopies the result of gen

143 Deficiency of the mechanosensory ion channel PPK1 gene or RNAi knockdown o

144 le in regulating feeding through specialized mechanosensory ion channels in Drosophila.

145 es the first molecular genetic evidence that mechanosensory ion channels in the enteric neurons are i

146 Specifically, we show that fish use their mechanosensory lateral line to first sense the curl (or

147 onal and molecular mechanisms that translate mechanosensory loss into improved olfactory acuity.

148 ypothesis that N-cadherin is part of a novel mechanosensory mechanism in VSMCs and plays an active ro

149 tterning in mouse touch domes, which contain mechanosensory Merkel cell-neurite complexes and abut pr

150 indbrain circuitry confirmed that visual and mechanosensory modalities share the same premotor output

151 Compared with mechanosensory modalities, however, vision requires a lo

152 motor programs, similar to those elicited by mechanosensory modalities.

153 sects rely on feedback from their visual and mechanosensory modalities.

154 The chemosensory and mechanosensory modules are separate and redundant; gluta

155 reveal a neural mechanism that underlies the mechanosensory monitoring of ingestion and negative feed

156 e apply our nanospring to human myosin VI, a mechanosensory motor protein, and demonstrate nanometre-

157 To this end, we analyzed in mechanosensory mutants food-dependent locomotion pattern

158 out the functional properties of identified mechanosensory nerve endings that innervate whisker foll

159 he anamniote lateral line system, comprising mechanosensory neuromasts and electrosensory ampullary o

160 lie mushroom body development and spacing of mechanosensory neuron dendrites, here we report that Dsc

161 t neurons express both isoforms, but the ALM mechanosensory neuron expresses only the exon-included i

162 kin, begins with activation of low-threshold mechanosensory neurons (LTMRs) that innervate the skin.

163 bitter gustatory receptor neurons (GRNs) and mechanosensory neurons (MSNs) are activated by slight co

164 al classes - motor neurons, interneurons and mechanosensory neurons - controls the mechanics of copul

165 In Drosophila, song is detected by antennal mechanosensory neurons and further processed by second-o

166 cifically expressed in particular subsets of mechanosensory neurons and modulate their sensitivity di

167 icient resolution to comprehensively catalog mechanosensory neurons and trace individual motor axons

168 factors comprises the response properties of mechanosensory neurons and, thus, the neural encoding of

169 Cutaneous mechanosensory neurons are activated by mechanical loads

170 e Drosophila aGPCR Latrophilin/dCIRL acts in mechanosensory neurons by modulating ionotropic receptor

171 Cutaneous mechanosensory neurons detect mechanical stimuli that ge

172 nteraction, whereas production of functional mechanosensory neurons does.

173 We propose that Kolmer-Agduhr cell-like mechanosensory neurons formed part of the mucociliary so

174 The cuticular mechanosensory neurons had only CsGABArdl and CspHCl2 su

175 orhabditis elegans, the general roles of the mechanosensory neurons have been defined, but most studi

176 Here, we show that dopaminergic mechanosensory neurons in C. elegans release the neuroho

177 xin as a regulator of synapse maintenance in mechanosensory neurons in C. elegans.

178 This song is perceived via mechanosensory neurons in the antennal Johnston's organ,

179 Furthermore, we demonstrate that inputs from mechanosensory neurons increase locomotor speed by prolo

180 Mechanosensory neurons initially extend wild-type neurit

181 sociated genes Shank3 or Mecp2 in peripheral mechanosensory neurons leads to region-specific brain ab

182 imotor integration, we recorded from primary mechanosensory neurons of awake, head-fixed mice as they

183 prior to axon termination in vivo Using the mechanosensory neurons of C. elegans, we found collapse

184 nd found they received direct input from the mechanosensory neurons or from each other.

185 Primary mechanosensory neurons play an important role in convert

186 BA(A) receptor agonist that acts directly on mechanosensory neurons reduced tactile over-reactivity i

187 In the hermaphroditic leech, T and P mechanosensory neurons respond to light touch and pressu

188 insect flight control, the identities of the mechanosensory neurons responsible for these functions a

189 Second-order mechanosensory neurons share the ambiguous responses of

190 ies to a sensory stimulus and is mediated by mechanosensory neurons signaling touch interactions amon

191 The sensation of touch is mediated by mechanosensory neurons that are embedded in skin and rel

192 , is mediated by proprioceptors, specialized mechanosensory neurons that convey information about the

193 f self-movement and position, is mediated by mechanosensory neurons that detect diverse features of b

194 Touch sensation is initiated by mechanosensory neurons that innervate distinct skin stru

195 nsory microdomains in mammalian skin and the mechanosensory neurons that innervate them.

196 al therapeutic strategy targeting peripheral mechanosensory neurons to treat tactile over-reactivity

197 hat Piezo2 differentially tunes all types of mechanosensory neurons with marked cell-class dependence

198 sport kinetics of membrane cargo in axons of mechanosensory neurons, identical to what is observed wh

199 ans contain a stereotyped array of different mechanosensory neurons, meaning that the distribution of

200 Here, using Caenorhabditis elegans mechanosensory neurons, we address this question.

201 and ion channel protein expression by single mechanosensory neurons, with the potassium ion channel K

202 ling during growth altered the patterning of mechanosensory neurons-a neural subpopulation that is di

203 tion after axotomy of Caenorhabditis elegans mechanosensory neurons.

204 This effect could be mediated by distinct mechanosensory neurons.

205 ts from both high- and low-threshold primary mechanosensory neurons.

206 diversity can fully block axon branching in mechanosensory neurons.

207 laments that tether NOMPC to microtubules in mechanosensory neurons.

208 the sensitivity and selectivity of mammalian mechanosensory neurons.

209 oprioceptive feedback, which is generated by mechanosensory neurons.

210 mechanical strain from the skin to cutaneous mechanosensory neurons.

211 togenetic stimulation of the touch receptor (mechanosensory) neurons.

212 (antenniform legs) covered with thousands of mechanosensory, olfactory, and gustatory sensilla.

213 Johnston's organ is the largest mechanosensory organ in Drosophila; it analyzes movement

214 ng development and remodeling of a zebrafish mechanosensory organ.

215 rganized epithelial cells that will form the mechanosensory organs of the posterior lateral line.

216 Thus, proper assembly of multicellular mechanosensory organs requires a double-negative circuit

217 of flies, known as halteres, are specialized mechanosensory organs that detect body rotations during

218 increased size and number of taste buds and mechanosensory organs, and shifts in many behavioural tr

219 Mechanosensory organs, such as the inner ear (which hous

220 t and mechanism of the action of dopamine in mechanosensory organs, such as the inner ear and lateral

221 ecorin) and dentin matrix protein-1 (DMP1, a mechanosensory/osteocyte marker), while osteoblast marke

222 The Hippo signaling cascade is a mechanosensory pathway that regulates morphogenesis, hom

223 Furthermore, the touch-induced mechanosensory pathway was transcriptionally misregulate

224 ine a complex architecture for the ascending mechanosensory pathway.

225 Defining the role of mechanosensory pathways in cartilage during OA pathogene

226 se findings suggest that aberrant epithelial mechanosensory pathways may contribute to pathologic der

227 We hypothesized that epithelial mechanosensory pathways regulated by keratinocyte-specif

228 arises from a linear summation of visual and mechanosensory pathways.

229 that C. elegans sleep can be induced through mechanosensory pathways.

230 Using the Caenorhabditis elegans mechanosensory PLM neurons, we found that posteriorly en

231 Thus, mechanosensory processing defects contribute to anxiety-

232 better understand biophysical mechanisms of mechanosensory processing, we investigated two cell type

233 ntribute to future progress in understanding mechanosensory processing.

234 The mechanosensory properties of RB neurons are consistent w

235 aGPCRs have been suggested to possess mechanosensory properties, though their mechanism of act

236 Here, we asked whether beta1 integrin, a mechanosensory protein in endothelial cells, is required

237 may provide design principles for a generic mechanosensory protein machine.

238 es for several proteins, PIEZO1, a mammalian mechanosensory protein; GLUT1, the glucose transporter;

239 tor with PDZ-binding motif (TAZ) are related mechanosensory proteins that bind to Smad transcription

240 ng mucin-like hormone receptor-like 2 (EMR2) mechanosensory receptor.

241 sophila now reveals that distinct classes of mechanosensory receptors and neurons fine tune the physi

242 Hair cells, the mechanosensory receptors of the inner ear, are responsib

243 Hair cells, the mechanosensory receptors of the inner ear, underlie the

244 pology changes, affecting a subpopulation of mechanosensory receptors, T (touch) neurons, but not P (

245 ereotyped across trials and animals in early mechanosensory regions, becoming more variable at higher

246 est subcluster expresses both gustatory- and mechanosensory-related genes, suggesting a novel type of

247 We found that the mechanosensory response in this mutant was reduced by 90

248 responsible for the nearly complete loss of mechanosensory response observed in the mutant fly.

249 ally, disrupting fs(1)h function impairs the mechanosensory response of class III da sensory neurons

250 uced recruitment to the fusion site, and the mechanosensory response of MyoII is amplified by chemica

251 ing cell mounts a Myosin II (MyoII)-mediated mechanosensory response to its invasive fusion partner.

252 cluding striatum and subpallium development, mechanosensory response, dopamine binding, synaptic neur

253 ngs indicate that Merkel cells actively tune mechanosensory responses to facilitate high spatio-tempo

254 stems rely on a common molecular pathway for mechanosensory responses.

255 ons compatible with monosynaptic inputs from mechanosensory Rohon-Beard neurons onto ipsilateral V2a

256 Our data suggest that the nucleus plays a mechanosensory role in inflammation by transducing cell

257 neme and extracellular structures supports a mechanosensory role of Chlamydomonas PKD2.

258 ts with truncated forms of talin confirm the mechanosensory role of the talin R3 subdomain and exclud

259 Several well-characterized mechanosensory roles such as touch, blood-pressure sensi

260 cterial MS channels, including the alternate mechanosensory roles that they may play in complex micro

261 rences relative to the prevailing visual and mechanosensory scenery provides a simple, yet effective,

262 e, swimming behavior, fin ray stiffness, and mechanosensory sensitivity.

263 This study investigated the mechanosensory signaling in brainstem astrocytes, as the

264 ptors and hair cells suggests that accessory mechanosensory signaling molecules define common feature

265 bipolar action facilitates the separation of mechanosensory signals carrying different physiological

266 the intake of both fluids and solids, using mechanosensory signals that arise from the upper digesti

267 Because MSD refolding may turn off GPIb-IX's mechanosensory signals, our results provide a mechanism

268 irection is computed by comparing left-right mechanosensory signals.

269 transports protein cargos within developing mechanosensory stereocilia.

270 in larval zebrafish to better understand how mechanosensory stimuli are represented along the spinal

271 We infer that TLAs convey feedforward mechanosensory stimuli to transiently activate MDNs in r

272 d the distance embryos swam in response to a mechanosensory stimulus (48 hpf).

273 rform a sequence of the two in response to a mechanosensory stimulus.

274 The touch dome is a highly patterned mechanosensory structure in the epidermis composed of sp

275 be an essential protein in hair bundles, the mechanosensory structure of hair cells critical for hear

276 ndicate that CIRL lowers cAMP levels in both mechanosensory submodalities.

277 zyx-1 mutants lacked PLM mechanosensory synapses as adult animals.

278 tant animals, suggesting that zyx-1 protects mechanosensory synapses from locomotion-induced forces.

279 preciated complexity of the larval zebrafish mechanosensory system and demonstrates how differences i

280 biased quantitative characterizations of the mechanosensory system by using reverse correlation analy

281 A myosin-II-based mechanosensory system controls cellular contractility an

282 FICANCE STATEMENT The fish lateral line (LL) mechanosensory system shares structural, functional, and

283 We term this mechanosensory system the SCWISh (survival through the C

284 In the diverse mechanosensory systems that animals evolved, the wavefor

285 on, and optogenetics platform to compare two mechanosensory systems: the gentle-touch (TRNs) and hars

286 Additional, presumed mechanosensory terminal axons entering via the labial ne

287 nnervated Gli1-expressing progenitors within mechanosensory touch dome epithelia are highly tumorigen

288 dings in locusts reveal that they respond to mechanosensory touch stimuli delivered to various parts

289 mechanical stimuli are detected by elaborate mechanosensory transduction (MT) machinery in highly spe

290 t colocalize, suggesting that their roles in mechanosensory transduction are independent.

291 aring that encodes a pore-forming subunit of mechanosensory transduction channels in inner-ear hair c

292 Mechanosensory transduction for senses such as proprioce

293 ly been identified as ion channels mediating mechanosensory transduction in mammalian cells.

294 e of the simplest paradigms for the study of mechanosensory transduction.

295 to study the basic biophysical principles of mechanosensory transduction.

296 al forces are detected by polymodal and pure mechanosensory trigeminal ganglion neurons.

297 -dependent dopamine signaling, including the mechanosensory TRP-4 channel in dopaminergic neurons and

298 lower displacement amplitudes, demonstrating mechanosensory tuning to fin mechanics and a consistent

299 , the skin on the nose is covered with domed mechanosensory units known as an Eimer's organs.

300 significant and nearly complete recovery of mechanosensory withdrawal thresholds.