ライフサイエンスコーパス: mechanotransduction

1 to regulation of capillary permeability and mechanotransduction.

2 m and the V-shaped hair bundle essential for mechanotransduction.

3 for the cadherin-catenin adhesion complex in mechanotransduction.

4 ty to cells and serves as a key component in mechanotransduction.

5 EC interaction, nitric oxide production, and mechanotransduction.

6 formational changes previously implicated in mechanotransduction.

7 its function and fully identify its role in mechanotransduction.

8 enotypic switch in prostate cancer cells via mechanotransduction.

9 mation of the tripartite complex and disrupt mechanotransduction.

10 ctrosensing and provide a role in lipid raft mechanotransduction.

11 d play a fundamental role in skeletal muscle mechanotransduction.

12 l bowel and that it is important for EC cell mechanotransduction.

13 n, and is an important component of cellular mechanotransduction.

14 geneous gene variants pertaining to cellular mechanotransduction.

15 of planar cell polarity (PCP) necessary for mechanotransduction.

16 r functions such as cell matrix adhesion and mechanotransduction.

17 s with FM4-64, which was used as a proxy for mechanotransduction.

18 ellular force generation, mechanosensing and mechanotransduction.

19 ike organelle with an important role in bone mechanotransduction.

20 re variants in genes with a role in cellular mechanotransduction.

21 al viral macropinocytosis, phagocytosis, and mechanotransduction.

22 t cytoskeletal proteins that are involved in mechanotransduction.

23 partners to filamentous actin, facilitating mechanotransduction.

24 may play broadly conserved roles in neuronal mechanotransduction.

25 nics that are likely sensed through cellular mechanotransduction.

26 naling, clathrin-independent endocytosis and mechanotransduction.

27 present an important mechanism for mediating mechanotransduction.

28 also inducing it de novo in a process termed mechanotransduction.

29 he classical neurotransmitter in endothelial mechanotransduction.

30 the extracellular milieu in a process called mechanotransduction.

31 ements, one of the main features of auditory mechanotransduction.

32 edical therapy and understanding complicated mechanotransduction.

33 oteolysis can act as a mechanism of cellular mechanotransduction.

34 o mechanical load through a process known as mechanotransduction.

35 d provide new insights into the mechanism of mechanotransduction.

36 ng specific alterations for key molecules in mechanotransduction.

37 ation that perturbs TMC1/2 binding abolishes mechanotransduction.

38 curred simultaneously with the appearance of mechanotransduction.

39 s and cytoplasm, and are co-regulated during mechanotransduction.

40 stem cell (LESC) residence and YAP-dependent mechanotransduction.

41 at chromatin state is a critical mediator of mechanotransduction.

42 nt the defining molecular process underlying mechanotransduction.

43 ed on changes in cell adhesion, cytoskeletal mechanotransduction [5], and/or proteolysis [6], most li

44 ound sensation are hypothesized to require a mechanotransduction adaptation mechanism.

45 Immunostaining uncovers active mechanotransduction after injury with increased focal ad

46 lmonary vascular stiffness and YAP-dependent mechanotransduction altered glutaminolysis, pulmonary va

47 as a locally regulated effector of cellular mechanotransduction and as a regulator of mechanically g

48 reatment also effectively restored hair cell mechanotransduction and attenuated progressive hair cell

49 toskeleton is an essential component of many mechanotransduction and cellular force generation pathwa

50 dynamic interplay between mechanosensation, mechanotransduction and cellular responses is unclear.

51 new insight into lamin-linked mechanisms of mechanotransduction and chromatin regulation and discuss

52 e model, in which lamin-mediated pathways in mechanotransduction and chromatin regulation are highly

53 s work deepens our understanding of podosome mechanotransduction and contributes tools that are widel

54 ty of the channel's pore module to influence mechanotransduction and downstream processes.

55 Aberrant mechanotransduction and dysregulated-microRNA pathways a

56 tributed to alterations in integrin-mediated mechanotransduction and focal adhesion (FA) dynamics.

57 YAP/TAZ are downstream effectors of cellular mechanotransduction and indeed we found that cell mechan

58 Cellular mechanotransduction and its downstream effects on gene e

59 stereocilia and microvilli are essential for mechanotransduction and maintaining their organization.

60 d, revealing the interdependence of podocyte mechanotransduction and maintenance of their physiologic

61 t keratinocytes are also critical for normal mechanotransduction and mechanically-evoked behavioral r

62 covered specific protein complexes linked to mechanotransduction and mechanotransmission within the s

63 ) signalling is central to the endothelium's mechanotransduction and networked activity.

64 es (SFK) are known to play critical roles in mechanotransduction and other crucial cell functions.

65 close localization, as well as their role in mechanotransduction and signaling, we hypothesized that

66 However, the molecular steps linking mechanotransduction and Sost suppression remain unknown.

67 ich protein 3, is thought to mediate cardiac mechanotransduction and stress responses, whereas the mi

68 gulate the Hippo pathway with an emphasis on mechanotransduction and the effects of this pathway on b

69 or with PDZ-binding motif (TAZ) in mediating mechanotransduction and vascular homeostasis.

70 ults in decreased ECM alignment, altered MPC mechanotransduction, and changes in genomic architecture

71 hlights the context-dependent role of YAP in mechanotransduction, and establishes that YAP does not m

72 rse functions including nuclear positioning, mechanotransduction, and meiotic chromosome movements.

73 uire transmembrane channel-like 1 (TMC1) for mechanotransduction, and mutations of the cognate geneti

74 regulating vascular permeability, regulating mechanotransduction, and reducing inflammation and coagu

75 Some components of the mechanotransduction apparatus have been identified, most

76 teract and report that it is achieved by the mechanotransduction apparatus in cutaneous mechanorecept

77 dentify proteins that comprise the hair cell mechanotransduction apparatus.

78 useful for exploiting ultrasound-stimulated mechanotransduction applications in the future.

79 mal rootlets, but hair bundle morphology and mechanotransduction are affected before the onset of hea

80 cal adhesion complex whose roles in cellular mechanotransduction are only recently being identified.

81 However, the mechanisms that control such mechanotransduction are poorly understood.

82 grity for long-term maintenance of hair cell mechanotransduction, are not known.

83 a HER2 pathway-targeted therapeutic via the mechanotransduction arm of the Hippo pathway.

84 r cell (NSPC) fate is strongly influenced by mechanotransduction as modulation of substrate stiffness

85 ctin-mediated regulation is conserved during mechanotransduction, as substrate compliance increased Y

86 we show that Sca4 reduces vinculin-dependent mechanotransduction at cell-cell junctions.

87 Mechanotransduction at E-cadherin junctions has been pos

88 an indispensable player in cadherin-specific mechanotransduction at intercellular junctions.

89 ot play a role in the bundle's key function, mechanotransduction, at least until after two months of

90 vide better insights into mechanisms driving mechanotransduction-based diseases.

91 We here present a molecular map of mechanotransduction, built in CellDesigner to warrant th

92 Intercellular junctions are crucial for mechanotransduction, but whether tight junctions contrib

93 , and tumors in vivo, was found to influence mechanotransduction by controlling full collagen-binding

94 Mechanotransduction by hair cell stereocilia lies at the

95 an unexpected function in the regulation of mechanotransduction by hair cells.

96 lular nucleic acid as a critical mediator of mechanotransduction by inducing the liberation of VWF, t

97 membrane tension exerts upstream control in mechanotransduction by periodically compressing and rela

98 w stimuli are encoded.SIGNIFICANCE STATEMENT Mechanotransduction by sensory hair cells represents a k

99 clude that TMIE is a subunit of the cochlear mechanotransduction channel and that channel function is

100 kyrin as an essential component of the TMC-1 mechanotransduction channel complex in the sensory cilia

101 as recently been identified as the principal mechanotransduction channel for proprioception.

102 norhabditis eleganssenses gentle touch via a mechanotransduction channel formed from the DEG/ENaC pro

103 Although prior candidates for the mechanotransduction channel have been proposed, each has

104 d, mTOMT binds to putative components of the mechanotransduction channel in hair cells and is essenti

105 Current findings indicate that the mechanotransduction channel in hair cells is a complex m

106 ) have been proposed to form the pore of the mechanotransduction channel of cochlear hair cells.

107 al TMIE deletions affect the response of the mechanotransduction channel to mechanical force.

108 The molecular composition of the mechanotransduction channel underlying auditory percepti

109 d is a pore-forming subunit of the hair cell mechanotransduction channel.

110 NOMPC fulfils all the criteria that apply to mechanotransduction channels and has 29 ankyrin repeats,

111 ICANCE STATEMENT Tip links transmit force to mechanotransduction channels at the tip of hair bundles

112 Mechanotransduction channels have been proposed as force

113 Here, we show that TMC1/2 cannot form mechanotransduction channels in cochlear hair cells with

114 How force gates mechanotransduction channels is a central question in th

115 How metazoan mechanotransduction channels sense mechanical stimuli is

116 Auditory hair cells contain mechanotransduction channels that rapidly open in respon

117 ss two molecularly and functionally distinct mechanotransduction channels with different subcellular

118 en shown to constitute the pore of hair cell mechanotransduction channels, but little is known about

119 ound, acceleration and touch are mediated by mechanotransduction channels, which convert mechanical s

120 ce, acceleration, hearing and pain relies on mechanotransduction channels, which convert mechanical s

121 hair cells contain two molecularly distinct mechanotransduction channels.

122 acellular tether that transmits force to TMC mechanotransduction channels.

123 ghts into the basis of mechanosensitivity of mechanotransduction channels.

124 n of selectin catch-bonds, revealing a novel mechanotransduction circuit that rapidly converts extend

125 ily, was identified as a core protein of the mechanotransduction complex in hair cells.

126 onstrate that the CR plays a key role in the mechanotransduction complex in hair cells.

127 he six touch receptor neurons (TRNs) using a mechanotransduction complex that contains the pore-formi

128 any forms, from dysfunction of the hair cell mechanotransduction complex to loss of specialized ribbo

129 n 2 binds to the components of the hair cell mechanotransduction complex, TMC1 and TMC2, and these in

130 e been shown to interact with members of the mechanotransduction complex.

131 f water motion by the lateral line relies on mechanotransduction complexes at stereocilia tips.

132 However, cellular mechanotransduction complexes remain to be characterized

133 expression of proteins linked to titin-based mechanotransduction (CryAB, ANKRD1, muscle LIM protein,

134 mic control of stereocilia morphology by the mechanotransduction current.

135 cal defects as the mutant mice age and while mechanotransduction currents can be evoked in early post

136 ensile strain (CTS) on mediators involved in mechanotransduction (Cx43, AKT), tissue remodelling (GAG

137 ing blast, and are associated with inner ear mechanotransduction, cytoskeletal reorganization, myelin

138 the intracellular and extracellular domains, mechanotransduction determines the optimum functionality

139 mechanosensitivity threshold (MT) increases mechanotransduction durations from hours to beyond 4 day

140 xidase 2 (Nox2) function as key mediators of mechanotransduction during both physiological adaptation

141 stigating the role of hemodynamic forces and mechanotransduction during morphogenesis.

142 n integrins' mechanosensation and effects on mechanotransduction, ECM modulation and cell-ECM interac

143 e the role of the lipid membrane in auditory mechanotransduction, especially in generating nonlinear

144 oach provides a toolset to better understand mechanotransduction events fundamental to cell biology.

145 proteins have been identified, the series of mechanotransduction events resulting in local leukocyte

146 ser-cut EHTs are a viable platform for novel mechanotransduction experiments and characterizing the b

147 nels have driven further developments in the mechanotransduction field.

148 During mechanotransduction, force allosterically alters the fun

149 Mechanotransduction from pulsed focused ultrasound (pFUS

150 However, a role for plexin proteins in mechanotransduction has not been examined.

151 re, but identifying the molecules underlying mechanotransduction has proved challenging.

152 Studies of cellular mechanotransduction have converged upon the idea that ce

153 d in more detail, and detailed mechanisms of mechanotransduction have started to emerge.

154 tify potent molecular candidates to modulate mechanotransduction, hence accelerate drug discovery tow

155 are of functional importance in chondrocyte mechanotransduction; however, direct evidence of mechani

156 ment as an adhesion-independent mechanism of mechanotransduction in 3D culture, and highlight stress

157 ted stiffening hydrogels to investigate cell mechanotransduction in a disease-relevant system.

158 and agent-based model (Mech-ABM), simulating mechanotransduction in a single osteoblast under externa

159 provide insights into the molecular basis of mechanotransduction in a tactile-specialist vertebrate.

160 strate that loss of TRPV4-mediated cartilage mechanotransduction in adulthood reduces the severity of

161 y distinct roles of TRPV4-mediated cartilage mechanotransduction in age-related and post-traumatic OA

162 , and show that both are deaf and exhibit no mechanotransduction in auditory hair cells, despite the

163 Mechanotransduction in bone cells plays a pivotal role i

164 n, and establishes that YAP does not mediate mechanotransduction in breast cancer.

165 Mechanotransduction in Caenorhabditis elegans touch rece

166 eful information about the important role of mechanotransduction in cancer, and how circulating tumor

167 the potential of pharmacologically targeting mechanotransduction in cancer.

168 the present study provide new insights into mechanotransduction in cardiac myocytes.

169 approach with which to systematically study mechanotransduction in confined environments.

170 ded to elucidate the role of Piezo1-mediated mechanotransduction in glaucoma.

171 x rigidity in fibrotic livers would activate mechanotransduction in hepatocytes and lead to inhibitio

172 llular perturbation of nuclear mechanics and mechanotransduction in live cells.

173 al control of axonal sorting and the role of mechanotransduction in myelination are largely unknown.

174 (Asic3(f/f)) and probe the role of ASIC3 in mechanotransduction in neurite-bearing Pv+ DRG neurons t

175 es-associated protein (YAP), is critical for mechanotransduction in NSCs.

176 ibrotic levels of matrix stiffness activated mechanotransduction in primary hepatocytes through focal

177 t sensitivity to dynamic stimuli and impairs mechanotransduction in Pv+ DRG neurons because of substr

178 ruction of the bundle is required for proper mechanotransduction in response to external forces and t

179 Protocadherin 15 (PCDH15) is required for mechanotransduction in sensory hair cells as a component

180 Piezo1 ion channels are mediators of mechanotransduction in several cell types including the

181 otubules increase cytoskeletal stiffness and mechanotransduction in striated muscle and that targetin

182 he cells to paclitaxel, suggesting a role of mechanotransduction in the evolution of drug resistance.

183 protrusions with graded heights that mediate mechanotransduction in the inner ear.

184 ur data also underscore the role of impaired mechanotransduction in the pathology of this hereditary

185 dentify both FOXC1 and FOXC2 as mediators of mechanotransduction in the postnatal lymphatic vasculatu

186 ke 2b (Tmc2b) is differentially required for mechanotransduction in the zebrafish lateral line.

187 ownstream bioeffects such as cell injury and mechanotransduction in ultrasound therapy, the fundament

188 fhydration was required for endothelial cell mechanotransduction in vitro as well as flow-induced dil

189 ghts into different biomechanical states for mechanotransduction, including the first estimate of the

190 RK, and Wnt were found to be involved in the mechanotransduction-induced phenotypic switching of pros

191 How mechanotransduction intersects with chemical and transcr

192 Mechanotransduction involves the sensing and translation

193 MKs adapt to extracellular stiffness through mechanotransduction involving actomyosin-based modulatio

194 ient murine hair cells start to develop, but mechanotransduction is affected and stereocilia deterior

195 ption, but its possible role in neurosensory mechanotransduction is disputed.

196 on; yet, direct evidence of tensin's role in mechanotransduction is lacking.

197 One of the earliest events in cellular mechanotransduction is often an increase in intracellula

198 Mechanotransduction is the process by which cells conver

199 However, the molecular mechanism of EC cell mechanotransduction is unknown.

200 patic stellate cell (HSC) activation through mechanotransduction, leading to increased secretion of E

201 Microtubule (MT) mechanotransduction links diastolic stretch to generatio

202 re mTOMT is critical for the assembly of the mechanotransduction machinery of hair cells.

203 We suggest that cellular mechanotransduction may be an important mechanism underl

204 However, the EC cell mechanotransduction mechanism is unknown.

205 pave the way to a full understanding of the mechanotransduction mechanism mediated by auditory cadhe

206 ight the structural features relevant to the mechanotransduction mechanism of each specific channel.

207 reflexes, thus being a unique model to study mechanotransduction mechanisms in this particular class

208 rials and a better understanding of cellular mechanotransduction mechanisms may support the translati

209 ve channels adapt distinctive structures and mechanotransduction mechanisms to fit their biological r

210 hat is transduced into cellular responses by mechanotransduction mechanisms.

211 stenotic kidney function, likely in part by mechanotransduction-mediated expression of angiogenic fa

212 at is achieved at the cellular level through mechanotransduction-mediated fine tuning of the extracel

213 Importantly, such a mechanotransduction-mediated phenotypic switch in prosta

214 ction as a motor that tensions the hair cell mechanotransduction (MET) complex, but conclusive eviden

215 d vestibular phenotypes are due to a lack of mechanotransduction (MET) in Tomt-deficient hair cells.

216 ndings reveal an unexpected paradigm for how mechanotransduction, metabolism, and cell survival are l

217 The mechanotransduction molecules and cell types that functi

218 Here, we find that mechanotransduction occurs independently of YAP in breas

219 rce-bearing protein linker for modulation of mechanotransduction of cells, and potentially acting as

220 ar shaping, cytoskeletal remodeling, and the mechanotransduction of external forces into biochemical

221 artilage, as well as the differentiation and mechanotransduction of mesenchymal stem cells, osteoblas

222 geneity of fibroblasts modulates the nuclear mechanotransduction of signals from the microenvironment

223 mations are sufficient to trigger osillatory mechanotransduction of YAP within cells, potentially aff

224 eveal a potent impact of hemodynamic Rho-YAP mechanotransduction on HE fate, relevant to de novo huma

225 the activation dynamics of molecules within mechanotransduction on the cellular response to mechanic

226 tle is known regarding the protein's role in mechanotransduction or as a modulator of RhoA signaling.

227 scriptional regulator with critical roles in mechanotransduction, organ size control, and regeneratio

228 In striated muscle, X-ROS is the mechanotransduction pathway by which mechanical stress t

229 to therapeutically target the TRPV4-mediated mechanotransduction pathway for the treatment of aging-a

230 sion generated by muscle activity triggers a mechanotransduction pathway in the epidermis that promot

231 This study identifies components of the mechanotransduction pathway in the oligodendrocyte linea

232 We identify a mechanotransduction pathway involving the Abl tyrosine k

233 discovered and characterized the microtubule mechanotransduction pathway linking diastolic stretch to

234 One reported mechanotransduction pathway of increased endothelial cel

235 Our findings reveal an EPHA2/LYN/TWIST1 mechanotransduction pathway that responds to mechanical

236 Here, we have identified a mechanotransduction pathway that translates laminar flow

237 ins like cten and suggest the existence of a mechanotransduction pathway via keratin network.

238 To uncover a new mechanotransduction pathway, we study the frequency-depe

239 ects may arise due to subtle defects in this mechanotransduction pathway.

240 detail the key signaling components of such mechanotransduction pathways and extracellular matrix co

241 le for examining BM stiffness and underlying mechanotransduction pathways as therapeutic targets for

242 This review describes mechanosensors and mechanotransduction pathways associated with fibrosis pr

243 Although our understanding of mechanotransduction pathways associated with pulmonary f

244 such as talin, whose folding status triggers mechanotransduction pathways by recruiting binding partn

245 Several mechanotransduction pathways have been uncovered, but th

246 Then we specially focus on mechanotransduction pathways in cancer progression and d

247 It is increasingly clear that mechanotransduction pathways play important roles in reg

248 Inhibition of mechanotransduction pathways prevented myofibroblast dif

249 stem cells (MSCs) has been shown to activate mechanotransduction pathways stimulating osteogenesis in

250 regulated membrane genes and the downstream mechanotransduction pathways such as Hippo/WNT/TGF-beta/

251 es of tissues are sensed and responded to by mechanotransduction pathways that facilitate sensing of

252 In addition, they also signal to cells via mechanotransduction pathways to control cell proliferati

253 late various cellular processes via distinct mechanotransduction pathways.

254 in vivo, we altered brain stiffness, blocked mechanotransduction pharmacologically and knocked down t

255 To directly evaluate whether mechanotransduction plays a role in glial cell different

256 Integrin-mediated mechanotransduction plays important roles in development

257 es in which aberrant integrin activation and mechanotransduction precipitate changes in cell spreadin

258 way that is upstream of previously described mechanotransduction processes and demonstrate that P2Y2

259 mbrane receptors that have a pivotal role in mechanotransduction processes by connecting the extracel

260 and mechanical factors could perturb typical mechanotransduction processes mediated by Cx43 signallin

261 ents were performed to elucidate the complex mechanotransduction processes of endothelial cells to pu

262 lacking endogenous MA channels to assay the mechanotransduction properties of various proteins.

263 This study helps elucidate basic mechanotransduction properties that may contribute to in

264 Mechanotransduction provides the link between modulation

265 Mechanotransduction refines and maintains row identity,

266 identify a new pathway by which endothelial mechanotransduction regulates FN assembly and flow-media

267 The study of mechanotransduction relies on tools that are capable of

268 However, the mechanisms of mechanotransduction remain elusive.

269 How LINC complexes mediate nuclear mechanotransduction remains unclear.

270 far, no arterial-specific mediators of this mechanotransduction response have been identified.

271 Our results suggest that filamin-FilGAP mechanotransduction response is best explained by a band

272 Agrin may act as a mechanotransduction signal in the extracellular matrix (

273 text, understanding the molecular details of mechanotransduction signaling may provide unique therape

274 Previous work has identified several mechanotransduction signaling processes that are involve

275 nt engagement with the brain ECM, activating mechanotransduction signaling to promote survival.

276 ether, we reveal a potent ERBB2-mediated YAP mechanotransduction signalling, involving EMT-like chara

277 une synapse formation, actin foci formation, mechanotransduction, T cell transendothelial migration,

278 ns the nuclear envelope and mediates nuclear mechanotransduction, the process by which mechanical sig

279 olecular and systems-level understandings of mechanotransduction through a multiscale model linking t

280 tretch-induced division orientation required mechanotransduction through E-cadherin cell-cell adhesio

281 Thus, endothelial flow mechanotransduction through the junctional complex is me

282 signalling in heart to include MT-dependent mechanotransduction through X-ROS.

283 tional effectors of the Hippo pathway and of mechanotransduction to myelin formation in Schwann cells

284 ad manipulate host intercellular tension and mechanotransduction to promote spread.

285 d allows cells/tissues to switch off nuclear mechanotransduction to restore initial chromatin state.

286 ese findings expand the influence of YAP/TAZ mechanotransduction to the control of autophagy and, vic

287 nd architecture influence gene localization, mechanotransduction, transcription, and cell function.

288 t as ligand-activated receptors and activate mechanotransduction triggered by changes in the physical

289 Together, these results suggest that mechanotransduction triggers the formation of bioelectri

290 reproduces the main properties of hair-cell mechanotransduction using only realistic parameters cons

291 ulation may enable the cell to fine tune its mechanotransduction via membrane receptors.

292 tic leukemia 1 (MKL1), a well-known actor in mechanotransduction, was found to be preferentially relo

293 metabolism, microenvironment, immunity, and mechanotransduction were discussed.

294 establish a fast, non-tension mechanism for mechanotransduction where disruption of ordered lipids i

295 Here, we design and analyze a model of mechanotransduction where each tip link attaches to two

296 However, the process of mechanotransduction whereby a mechanical stimulus gives

297 New work describes a novel mechanism of mechanotransduction, whereby force-induced membrane defo

298 signals into intracellular responses through mechanotransduction, which alters cell maintenance, prol

299 suggests how they may function in inner-ear mechanotransduction, with implications for other cadheri

300 rway stretch sensor and that Piezo2-mediated mechanotransduction within various airway-innervating se