ライフサイエンスコーパス: medicinal chemistry

1 the delivery of valuable building blocks for medicinal chemistry.

2 ines are ubiquitous materials in organic and medicinal chemistry.

3 of molecules to identify starting points for medicinal chemistry.

4 ell with experimental properties relevant to medicinal chemistry.

5 e-based compounds are of great importance in medicinal chemistry.

6 o a CF(2) H group would be of great value to medicinal chemistry.

7 significant applications in theoretical and medicinal chemistry.

8 e a versatile and unique functional group in medicinal chemistry.

9 oles, which are very important compounds for medicinal chemistry.

10 igh-value building blocks for application in medicinal chemistry.

11 re prolific synthons in natural products and medicinal chemistry.

12 s: a broad subset of compounds ubiquitous in medicinal chemistry.

13 which are of high interest in synthetic and medicinal chemistry.

14 cyclobutyl-spirooxindoles for direct use in medicinal chemistry.

15 ns across many fields, including biology and medicinal chemistry.

16 ion and use of virtual chemical libraries in medicinal chemistry.

17 l in various fields of materials science and medicinal chemistry.

18 ment, mode of action studies, and eventually medicinal chemistry.

19 e valuable substructures to be considered in medicinal chemistry.

20 y yielding access to motifs commonly used in medicinal chemistry.

21 ctures, which is a topic of high interest in medicinal chemistry.

22 ssays are the linchpin of drug discovery and medicinal chemistry.

23 sis, biological processes, and materials and medicinal chemistry.

24 on of fluorine is of paramount importance in medicinal chemistry.

25 discovery, thereby increasing innovation in medicinal chemistry.

26 one of the most employed reactions in modern medicinal chemistry.

27 pen new windows for asymmetric catalysis and medicinal chemistry.

28 Indazoles represent a privileged scaffold in medicinal chemistry.

29 eas of pharmacology, pharmacy, oncology, and medicinal chemistry.

30 ds are fundamental building blocks of modern medicinal chemistry.

31 latform for their further optimisation using medicinal chemistry.

32 ic chiral scaffolds are privileged motifs in medicinal chemistry.

33 for late stage functionalization in parallel medicinal chemistry.

34 articular relevance for chemical biology and medicinal chemistry.

35 r (bio)-isostere, is a classical strategy in medicinal chemistry.

36 th emphasis on recent developments impacting medicinal chemistry.

37 duct identification and analysis, as well as medicinal chemistry.

38 nal scaffolds, which may find application in medicinal chemistry.

39 dicinal Chemistry Letters and the Journal of Medicinal Chemistry.

40 important areas of research in the field of medicinal chemistry.

41 e functionalization of scaffolds relevant to medicinal chemistry.

42 much attention due to their significance in medicinal chemistry.

43 e total synthesis of natural products and in medicinal chemistry.

44 bly of various isotryptamine derivatives for medicinal chemistry.

45 n the female perspective within the field of medicinal chemistry.

46 with potential applications in synthesis and medicinal chemistry.

47 neurin and NFATc3, through computational and medicinal chemistry.

48 s frequently encountered within contemporary medicinal chemistry.

49 y step, emphasizing its potential utility in medicinal chemistry.

50 functional groups have thus far been rare in medicinal chemistry.

51 his method for target molecule synthesis and medicinal chemistry.

52 he molecule, form a foundation within modern medicinal chemistry.

53 alysis of chemical reactions used in current medicinal chemistry (2014), three decades ago (1984), an

54 n-coupled receptors can be exploited through medicinal chemistry, a comparable pharmacological approa

55 tically probing one of its exit vectors is a medicinal chemistry activity that can benefit from molec

56 This Perspective reviews the biological and medicinal chemistry advances over the past 3 decades wit

57 Recent advances in organic synthesis and medicinal chemistry allow further optimization of lead e

58 ides are increasingly important molecules in medicinal chemistry and agrochemistry, but their prepara

59 phatic amines - valuable building blocks for medicinal chemistry and agrochemistry.

60 ues are also valuable as building blocks for medicinal chemistry and as tools for chemical biology.

61 enantioenriched diamines for applications in medicinal chemistry and catalysis.

62 of case studies illustrating applications in medicinal chemistry and chemical biology.

63 yl compounds are valuable building blocks in medicinal chemistry and chemical industry.

64 tem, generating motifs which are valuable in medicinal chemistry and chiral ligand design.

65 ime class of heterocycles, very important to medicinal chemistry and drug design due to not only thei

66 ontaining compounds are increasingly used in medicinal chemistry and drug design in order to establis

67 thus enabling their potential application in medicinal chemistry and drug design.

68 cules is a highly desirable approach used in medicinal chemistry and drug discovery processes to alte

69 luorinated building blocks of high value for medicinal chemistry and drug discovery.

70 s to building blocks which are important for medicinal chemistry and drug discovery.

71 teractions, and they have a broad utility in medicinal chemistry and drug discovery.

72 mino alcohols, important building blocks for medicinal chemistry and drug discovery.

73 nteresting and versatile functional group in medicinal chemistry and drug discovery.

74 eads is still a dynamic and fertile field in medicinal chemistry and drug discovery.

75 pha-aminoboronic acids play a unique role in medicinal chemistry and have emerged as privileged pharm

76 p and transition metal chemistry, catalysis, medicinal chemistry and materials science.

77 , classes of compounds that are important to medicinal chemistry and natural product synthesis.

78 te a new approach that fuses the concepts of medicinal chemistry and protein design, and paves the wa

79 etween trifluoromethylation in materials and medicinal chemistry and structural biology and biotechno

80 vo Following lead identification, subsequent medicinal chemistry and structure-activity relationship

81 d KHK inhibitors by combined use of parallel medicinal chemistry and structure-based drug design.

82 s of nucleic acids is an important branch of medicinal chemistry and the nature of these interactions

83 cyclopropyl-gamma-lactones of high value for medicinal chemistry and the synthesis of natural product

84 evalence of drug ring combinations in modern medicinal chemistry and to identify areas of under-repre

85 as a significant and novel emerging area for medicinal chemistry and we provide an overview of one of

86 Medicinal chemistry and, in particular, drug design have

87 s together in order to improve computational medicinal chemistry and, most importantly, deliver bette

88 icle entitled "Chromone: A Valid Scaffold in Medicinal Chemistry" and is mainly focused on chromones

89 es and disadvantages of the ethynyl group in medicinal chemistry, and (3) the impact of the ethynyl g

90 cations of this method in organic synthesis, medicinal chemistry, and chemical biology.

91 symmetric catalysis, agricultural chemistry, medicinal chemistry, and so forth.

92 Indoles are essential heterocycles in medicinal chemistry, and therefore, novel and efficient

93 Scaffolds are a core concept in medicinal chemistry, and they can be the focus of multip

94 rds alkylated benzenesulfonamides poised for medicinal chemistry applications and traceless reductive

95 oms have been at the center of many rational medicinal chemistry applications in drug design.

96 The potential utility of these methods in medicinal chemistry applications is highlighted.

97 lopment, macromolecular crystallography, and medicinal chemistry applications is now warranted.

98 es, which can present a potential utility in medicinal chemistry applications.

99 derivatives appearing in recent patents for medicinal chemistry applications.

100 ility in organic synthesis, particularly for medicinal chemistry applications.

101 Here, starting with a medicinal chemistry approach, Baker et al. generate an i

102 accine candidate that was identified using a medicinal chemistry approach.

103 Medicinal chemistry approaches are now engaged to develo

104 Over the past years, medicinal chemistry approaches from a kinetic perspectiv

105 GPCRs and their disease indications and the medicinal chemistry approaches toward novel allosteric m

106 w, we discuss and provide an overview of the medicinal chemistry approaches toward the development of

107 ved from much wider publishing of industrial medicinal chemistry are described.

108 rawbacks influencing the use of OH groups in medicinal chemistry are discussed and illustrated with f

109 Examples of the use of oxetanes in medicinal chemistry are reported, including a collation

110 d BCP moieties have become widely adopted in medicinal chemistry as para-phenyl ring replacements(2).

111 attractive to practitioners of synthetic and medicinal chemistry as well as in other areas that use b

112 the training of chemistry undergraduates in medicinal chemistry (as practiced in industry) in two mo

113 o, it only recently proved its usefulness in medicinal chemistry, as exemplified by the increasing nu

114 omplexes have recently found applications in medicinal chemistry, as well as in materials science.

115 industrial medicinal chemistry with over 600 medicinal chemistry-based publications and patents appea

116 is the most-used bond-construction method in medicinal chemistry because the chemistry is reliable an

117 ontaining one fluorine atom are valuable for medicinal chemistry because they mimic common tertiary s

118 Such motifs are highly coveted in medicinal chemistry, because extensive substitution abou

119 Azetidines are important motifs in medicinal chemistry, but there are a limited number of m

120 hus creates opportunities across organic and medicinal chemistry, by enabling the wider exploration o

121 lysis of the data set, we have carried out a medicinal chemistry campaign in order to define the stru

122 The result of this medicinal chemistry campaign is PXS-5120A (12k), a poten

123 We now present a detailed account of the medicinal chemistry campaign leading to this molecule, w

124 In this study, a successful medicinal chemistry campaign that exploited virtual, bio

125 Here we carried out a medicinal chemistry campaign that led to the discovery o

126 We undertook a focused medicinal chemistry campaign to simultaneously preserve

127 A key challenge encountered in the medicinal chemistry campaign was maintaining a balance b

128 Recent medicinal chemistry campaigns along with a brief overvie

129 The use of an acetylene (ethynyl) group in medicinal chemistry coincides with the launch of the Jou

130 interest to the computational chemistry and medicinal chemistry communities in recent decades.

131 still not available to the computational and medicinal chemistry communities.

132 ss" dramatically altered the behavior of the medicinal chemistry community for a long time.

133 It is well understood in the medicinal chemistry community that potency measured with

134 inates) have seen alacritous adoption by the medicinal chemistry community, as evidenced by the recen

135 of action has attracted the interest of the medicinal chemistry community.

136 ce for both FBDD practitioners and the wider medicinal chemistry community.

137 unctional group as a structural alert by the medicinal chemistry community.

138 Here we use medicinal chemistry concepts to assemble a panel of mole

139 Our current medicinal chemistry data also revealed that the RNase H

140 er of observations of each transformation in medicinal chemistry databases.

141 This Perspective will discuss medicinal chemistry design approaches to novel isoform-s

142 ides a valuable component for machine-driven medicinal chemistry design workflows.

143 to facilitate the synthesis of analogues and medicinal chemistry development efforts in a time- and r

144 ounds, ranging from approved drugs to recent medicinal chemistry developments.

145 Herein, we disclose the medicinal chemistry discovery and the early clinical dev

146 d end-to-end prototypes realized to expedite medicinal chemistry discovery cycles.

147 We report herein the medicinal chemistry discovery of a series of LOX inhibit

148 orinated pyrazoles play an important role in medicinal chemistry, drug discovery, agrochemistry, coor

149 erocycles that hold great promise in current medicinal chemistry due to their desirable pharmacokinet

150 ch as proteins, RNA or DNA nor light-induced medicinal chemistry (e.g., photodynamic therapy) are cov

151 The medicinal chemistry effort featured the judicious placem

152 In practice, all medicinal chemistry efforts and eventual commercializati

153 sent paper, we report for the first time the medicinal chemistry efforts conducted around the pharmac

154 Medicinal chemistry efforts confirmed activity of 70 pur

155 Perspective highlights some of the dedicated medicinal chemistry efforts directed at inhibiting the f

156 Herein, we describe the medicinal chemistry efforts focused on a cGMP-dependent

157 Medicinal chemistry efforts have resulted in more than 1

158 Initial medicinal chemistry efforts identified key elements for

159 elopment for ASD and the state-of-the-art of medicinal chemistry efforts in related areas.

160 This publication covers the medicinal chemistry efforts resulting in the identificat

161 pattern processing in the ER and will enable medicinal chemistry efforts targeting human 2OG oxygenas

162 These findings should help focus medicinal chemistry efforts that desire to optimize Nurr

163 The extensive medicinal chemistry efforts to discover both isoform sel

164 ission-blocking agents, herein we report our medicinal chemistry efforts to study the potential of th

165 those privileged scaffolds that have guided medicinal chemistry efforts yielding molecules that have

166 e latent electrophiles not typically used in medicinal chemistry efforts, until one reacts with a pro

167 and serve as a starting point for subsequent medicinal chemistry efforts.

168 ons (PPIs) remains an important challenge in medicinal chemistry, efforts have been made to mimic thi

169 esents the current end-point of an extensive medicinal chemistry endeavor that spans almost three dec

170 e lessons can be potentially extrapolated to medicinal chemistry endeavors in the taxane family, as w

171 Here, we report a medicinal chemistry evaluation of a collection of TASIN

172 original descriptor MCE-18, which stands for medicinal chemistry evolution, 2018, and this measure ca

173 of chemical space render decision making in medicinal chemistry exceptionally demanding.

174 Through medicinal chemistry exploration, we established a robust

175 principle could find a broad interest in the medicinal chemistry field as it can be useful not only f

176 ulfoximines have been largely disregarded in medicinal chemistry for a long time.

177 etabolic pathways is now a major strategy in medicinal chemistry for targeting cancers.

178 lass of TMEM16A inhibitors, which, following medicinal chemistry, gave analog 2-bromodifluoroacetylam

179 in protein-ligand complexes, completing the medicinal chemistry guide to rational halogen interactio

180 The use of deuteration in medicinal chemistry has exploded in the past years, and

181 Moreover, the broad utility of halogens in medicinal chemistry has motivated the use of hybrid quan

182 Recent advances in medicinal chemistry have established inhibitors targetin

183 otypes for guiding large-scale screening and medicinal chemistry have not been shown.

184 bered rings, widespread motifs in nature and medicinal chemistry, have fascinated chemists ever since

185 e been used to great affect in synthesis and medicinal chemistries, homoenolates and their higher hom

186 coincides with the launch of the Journal of Medicinal Chemistry in 1959.

187 ange of applications in physical organic and medicinal chemistry in the past 55+ years.

188 Herein, we report our medicinal chemistry investigation involving the explorat

189 cinal chemistry knowledge in the training of medicinal chemistry is discussed.

190 usion, the value of spirocyclic scaffolds in medicinal chemistry is discussed.

191 sed bicyclic piperidines-building blocks for medicinal chemistry-is developed.

192 For medicinal chemistry, it would be very useful to derive m

193 Bibliometric data from seven medicinal chemistry journals between 2000 and 2019 are c

194 ally the role of a corpus of robustly tested medicinal chemistry knowledge in the training of medicin

195 Further analysis revealed inherent medicinal chemistry knowledge potentially useful to chem

196 Inspired by problems faced during medicinal chemistry lead optimization, we extend our mod

197 es, an heterocyclic moiety commonly found in medicinal chemistry leads and drugs.

198 structure-based drug design and traditional medicinal chemistry led to the discovery of compound 23

199 ng structure-based drug design, and parallel medicinal chemistry led to the identification of pyridin

200 d 2019 are collated including Bioorganic and Medicinal Chemistry Letters and the Journal of Medicinal

201 of various FGs in molecules described in the medicinal chemistry literature over the last 40 years an

202 de the continued extraction of data from the medicinal chemistry literature, new sources of bioactivi

203 ety of fields including biomedical research, medicinal chemistry, materials science, catalysis, and o

204 Through compound screening and medicinal chemistry, novel inhibitors of p300/CBP HAT wi

205 ion has long been the result of serendipity, medicinal chemistry now tends to design polypharmacology

206 This Perspective of the published essential medicinal chemistry of cannabidiol (CBD) provides eviden

207 This manuscript reviews the essential medicinal chemistry of curcumin and provides evidence th

208 , it is hoped that further research into the medicinal chemistry of photopharmacological agents will

209 her advances have opened new avenues for the medicinal chemistry of PS-ASOs and research on all eleme

210 Further medicinal chemistry on the compounds' basic scaffold cou

211 pathological conditions, opens a plethora of medicinal chemistry opportunities to develop receptor mo

212 e synthesis of 65 new analogues arising from medicinal chemistry optimization at different sites on t

213 y high-throughput screening and the targeted medicinal chemistry optimization for two molecular scaff

214 We report the discovery and medicinal chemistry optimization of a novel series of py

215 We report herein the design, synthesis, and medicinal chemistry optimization of the benzylamine seri

216 n be a useful approach to guide this type of medicinal chemistry optimization once it has been valida

217 Medicinal chemistry optimization resulted in 83, an oral

218 dentified from high-throughput screening and medicinal chemistry optimization such as olesoxime (11),

219 Medicinal chemistry optimization that paid particular at

220 Herein we report the structure-based design, medicinal chemistry optimization, and unique ADME assays

221 Without any medicinal chemistry optimization, the most potent hit ha

222 d diverse applications in areas ranging from medicinal chemistry over structural biochemistry to orga

223 plays a paramount role in pharmaceutical and medicinal chemistry owing to its synthetic merits and th

224 ternative class of CA inhibitor, wherein the medicinal chemistry pedigree of primary sulfonamides has

225 mple, combustion systems, material sciences, medicinal chemistry, planetary sciences, and biochemistr

226 Medicinal chemistry plays a fundamental and underlying r

227 pplications in many different areas, such as medicinal chemistry, polymer synthesis, organocatalysis,

228 derived metabolites can represent innovative medicinal chemistry possibilities toward the identificat

229 A medicinal chemistry program allowed delivery of compound

230 The compounds generated during this medicinal chemistry program and others from the GSK coll

231 Here we describe a medicinal chemistry program starting from amicarbalide t

232 The medicinal chemistry program that led to PFI-3 from an in

233 f these atypical bioisosteres when used in a medicinal chemistry program, the search to find a suitab

234 We report here the results of a medicinal chemistry programme focused on an imidazopyrid

235 s using ligands that have been developed via medicinal chemistry programmes, but where assessed activ

236 This methodology promises to enable new medicinal chemistry programs aimed at the modulation of

237 activities in assays often propagate through medicinal chemistry programs and compromise their outcom

238 uilding blocks with potential application in medicinal chemistry programs as p-substituted aniline bi

239 2, RAD51, RAD52, and PD-1) and discusses the medicinal chemistry programs being used to interrogate t

240 e to accelerate and improve success rates in medicinal chemistry programs by more effectively leverag

241 receptor (CB2R), raised the interest of many medicinal chemistry programs for its therapeutic relevan

242 hroughput is suitable to support preclinical medicinal chemistry programs in late lead optimization,

243 by utilizing survey data obtained from five medicinal chemistry programs in the Midwest and recent a

244 aining ring systems are increasingly used in medicinal chemistry programs to modulate druglike proper

245 rmaceutical industry, ranging from advancing medicinal chemistry programs to self-optimizing syntheti

246 or the identification of lead candidates for medicinal chemistry programs.

247 is a key metric that is often used to drive medicinal chemistry programs.

248 several design-synthesize-test iterations on medicinal chemistry projects where they carry out the de

249 uccessfully demonstrated in several relevant medicinal chemistry projects, it is now an appropriate t

250 Finally, we calculated medicinal chemistry properties of benzenoid containing A

251 we offer a critical review of the published medicinal chemistry properties of CBD, as well as precis

252 O-trisubstituted hydroxylamines suitable for medicinal chemistry purposes in good to excellent yields

253 cient quantities of each target analogue for medicinal chemistry purposes.

254 Small molecule medicinal chemistry relies on iterative learning cycles

255 pective traces the decades long evolution of medicinal chemistry required to advance small molecule C

256 ide adaptation of this emerging reaction for medicinal chemistry requires a broad understanding of su

257 l methods are becoming a feasible reality in medicinal chemistry research due to improved computation

258 molecular entities which can be employed in medicinal chemistry research through diverse C-H activat

259 ost promising scaffold was optimized through medicinal chemistry resulting in enhanced potency and se

260 ive RNA ligands, including: 1) Compliance to medicinal chemistry rules, 2) distinctive structural fea

261 Recent high-throughput medicinal chemistry screens have identified multiple pro

262 ncluding coverage of the new developments in medicinal chemistry since 2015, and also endeavors to sp

263 e scaffold, which are also relevant from the medicinal chemistry standpoint.

264 However, SAM itself represents a poor medicinal chemistry starting point for a selective, cell

265 New medicinal chemistry strategies are being implemented to

266 hlight recent developments toward innovative medicinal chemistry strategies based on continuous flow

267 Inhibitor design and medicinal chemistry strategies for development of novel

268 In this report, we present various medicinal chemistry strategies that were used to increas

269 ified from a screen of 10k compounds and the medicinal chemistry strategies undertaken to progress th

270 Medicinal chemistry strategies used to derisk bioactivat

271 A medicinal chemistry strategy based on modifications of t

272 A previously untested medicinal chemistry strategy of deliberate file enrichme

273 we initiated an iterative program combining medicinal chemistry, structural biology, biochemical tes

274 identified by high-throughput screening and medicinal chemistry structure optimization.

275 Consequently, for decades medicinal chemistry studies aiming at developing skin de

276 lpha-substituted piperazines for early stage medicinal chemistry studies, a simple, general synthetic

277 ation make them useful prototypes for future medicinal chemistry studies.

278 innovative nanomaterials and applications in medicinal chemistry such as the development of protein-p

279 the delivery of valuable building blocks for medicinal chemistry, such as aryldifluoromethyl and diar

280 view provides a timeline of PARP biology and medicinal chemistry, summarizes the pathophysiological p

281 Using iterative cycles of medicinal chemistry synthesis and testing, we identified

282 ink predictive models can be integrated into medicinal chemistry synthesis workflows, how they are cu

283 intermediates with KDM5B, which is a current medicinal chemistry target for cancer.

284 tumor regression studies, and the inorganic medicinal chemistry that led to clinical implementation

285 allenges, particularly with attention to the medicinal chemistry that will be unavoidably required fo

286 s with great potential in areas ranging from medicinal chemistry to biomaterial science.

287 ting immense interest in epigenetic-focused, medicinal chemistry to develop structurally guided chemi

288 host-based targets that can guide efforts in medicinal chemistry to discover new drugs for this devas

289 hat is broadly similar is a common method in medicinal chemistry to modulate the physical and biologi

290 d with an in silico support can be used as a medicinal chemistry tool to assist rational molecular de

291 This work thus provides the first medicinal chemistry toolbox (experimental procedures and

292 earlier achievements in total synthesis and medicinal chemistry, we used chemical proteomics to iden

293 s is that between carbohydrate chemistry and medicinal chemistry, where there are equally many opport

294 ation of complex molecules is of interest in medicinal chemistry, wherein the preparation of structur

295 of the use of chemical protein synthesis in medicinal chemistry with a special focus on the producti

296 at the forefront of academic and industrial medicinal chemistry with over 600 medicinal chemistry-ba

297 spectra in the optimization of compounds for medicinal chemistry, with particular application to the

298 cells have advanced and are now integral to medicinal chemistry workflows.

299 Cyclobutane rings are important in medicinal chemistry, yet few enantioselective methods ex

300 Compound screening followed by medicinal chemistry yielded a series of drug-like, broad