ライフサイエンスコーパス: megabase

1 had non-tTMB-high status (<10 mutations per megabase).

2 1 megabases of the total genome size of 61.1 megabases).

3 ed enhancer-enhancer hubs spanning up to one megabase.

4 ng fragments ranging from 5 kilobases to > 1 megabase.

5 MB-high status was at least 10 mutations per megabase.

6 th a median of 0.35 non-silent mutations per megabase.

7 human genome with Hi-C at a resolution of 1 megabase.

8 gion; TMB-high was defined as >=20 mutations/megabase.

9 e into 625 contigs with an N50 length of 2.4 megabases.

10 ordination of NL contacts, even over tens of megabases.

11 stance scales, ranging from tens of bases to megabases.

12 tion control is apparently lost over several megabases.

13 el transcriptional interaction spanning 14.3 megabases.

14 lted in a final genome error rate of 1 in 10 megabases.

15 r of its six chromosomes, each spanning many megabases.

16 y 96 loci from a genome of approximately 400 megabases.

17 arthritis severity at a resolution of a few megabases.

18 o be caused by a deletion of approximately 2 megabases.

19 been impractical for regions beyond tens of megabases.

20 100 kilobases per minute, reaching up to 30 megabases.

21 methylated domains (PMDs) which extend up to megabases.

22 pha-satellite DNA, which spans up to several megabases.

23 generate extended haplotypes on the order of megabases.

24 ow mutational burden (number of mutation per megabase, 0.8 and 4, respectively).

25 ished dosage of the genes deleted in the 1.5-megabase 22q11 minimal critical deleted region in a mous

26 ion of Ginkgo and locate it to the area from megabases 48 to 75 on chromosome 2.

27 esis, and progress toward assembly of a 3.97-megabase, 57-codon Escherichia coli genome in which all

28 of the hypermutated phenotype (>12 mutations/megabase); 6 had mutation frequencies >200/megabase, and

29 y, 0.02 and 0.07 nonsynonymous mutations per megabase, a dramatically lower average mutational freque

30 e characterization of haplotypes that extend megabases along the human genome using high molecular we

31 lele-specific chromatin analysis of over 100 megabases along the maternally or paternally duplicated

32 f CENP-A and histone H3.1 binding within the megabase, alpha-satellite repeat-containing centromeres

33 ogies, which has led to a decreased cost per megabase and an increase in the number and diversity of

34 exonic somatic mutation rate of 12.0 events/megabase and identified the majority of genes previously

35 we produced high-quality sequence data of 59 megabases and assembled ~200,000 reads into 19,501 conti

36 ocrustacean Daphnia pulex, which is only 200 megabases and contains at least 30,907 genes.

37 nal centromeres span several kilobases up to megabases and do not seem to have DNA sequence specifici

38 ntotheonella' with genomes of greater than 9 megabases and multiple, distinct biosynthetic gene clust

39 nome-wide array data to identify ROHs (>1 megabase) and conducted global burden and locus-specific

40 ates even in heavily treated CRPCs (2.00 per megabase) and confirmed the monoclonal origin of lethal

41 had relatively few SNVs (average of 5.9 per megabase) and only a single SV.

42 ic mutation rate (0.31 non-silent events per megabase) and wide mutational diversity.

43 nts had tTMB-high status (>=10 mutations per megabase), and 688 (87%) patients had non-tTMB-high stat

44 s/megabase); 6 had mutation frequencies >200/megabase, and 5 of these had somatic mutations in POLE,

45 habditis elegans genome at chromosome, three megabase, and 500 kb scales.

46 somatic mutation rate was 1.2 mutations per megabase, and there was a median of 230 somatic rearrang

47 The LBA111 genome is 1.23 megabases, and it is closely related to that of Megaviru

48 TMB), defined as the number of mutations per megabase; and clinical characteristics gathered from EHR

49 ty, from simple "point" centromeres to multi-megabase arrays of DNA satellites, has defied explanatio

50 d from sequencing, with > 15.5 mutations-per-megabase as a cut-point to define TMB-H tumors.

51 raveling from the origin to the terminus (>2 megabases) at rates >50 kilobases per minute.

52 and observe ultra-long-distance pieQTLs (>1 megabase away), including several disease-risk variants.

53 utionary distance and frequently are located megabases away from target developmental genes.

54 suspected, with enhancers sometimes located megabases away.

55 he effects of noncoding SNPs both nearby and megabases away.

56 example, FOXO1, AZI2) often situated several megabases away; and finally, regions associated with dif

57 At 99 megabases, B. antarctica has the smallest insect genome

58 mes in pools, we assembled a sequence of 774 megabases carrying 5326 protein-coding genes, 1938 pseud

59 both small-scale (kilobase) and large-scale (megabase) changes in chromatin accessibility and nucleos

60 IR induces rapid modification of megabase chromatin domains surrounding DSBs via poly-ADP

61 n centromeres are positioned within specific megabase chromosomal regions containing alpha-satellite

62 map length (P), measured in centimorgans per megabase (cM/Mb).

63 h hierarchy of structural layers, from multi-megabase compartments to sub-megabase topologically asso

64 ic role of Sycp3, CRISPR-loxP-mediated multi-megabase deletions of the Slx (5 Mb) and Slxl1 (2.3Mb) a

65 including medium size (from 1 kilobase to 1 megabase) deletions and duplications, and balanced inver

66 id strains with fewer than two mutations per megabase displayed a 25% decrease in lifespan, suggestin

67 that interacts in cis with PTHLH over a 24.4-megabase distance and in trans with the sex-determining

68 es within FTO are functionally connected, at megabase distances, with the homeobox gene IRX3.

69 rrelated with the protein-coding genome over megabase distances.

70 regulates an imprinted gene cluster nearly a megabase distant from IGF2.

71 ssing structural variation across contiguous megabase DNA regions.

72 tive compartments, and partitioning into sub-megabase domains (TADs).

73 1 mutant cells reveals the appearance of sub-megabase domains defined by gene activation, CpG hyperme

74 ganization of individual chromatin polymers, megabase domains, and mitotic chromosomes.

75 dependent chromatin modifications over multi-megabase domains.

76 eport the sequence and annotation of the 458-megabase draft genome of Lucilia cuprina.

77 from 10-20 kb (enhancers/repressors) to many megabases during intra- and inter-chromosomal interactio

78 enomic loci separated by tens to hundreds of megabases, even in the absence of transcription.

79 gous end-joining using kilobase, rather than megabase, fragments of DNA, which we refer to as "stitch

80 This enormous, 3.9-megabase genome contains six genome equivalents of forei

81 The 37-megabase genome of C. cinerea was sequenced and assemble

82 Here, we decode the compact 73.8-megabase genome of Dimorphilus gyrociliatus, a meiobenth

83 We sequenced and assembled >94% of the 640-megabase genome of Eucalyptus grandis.

84 hanisms of adaptation, we sequenced the 13.7-megabase genome of G. sulphuraria.

85 The 23-megabase genome of Plasmodium falciparum, the causative

86 sis of a high-quality assembly from the 1180-megabase genome of Symbiodinium kawagutii.

87 Here we report the 409-megabase genome sequence of the blue-petal water lily (N

88 ic mutations and yield an estimated 17.7 per megabase genome-wide somatic mutation rate.

89 ovides a set of precise, rapid, large-scale (megabase) genome-engineering operations for creating div

90 The 115- to 141-megabase genomes offer insights into the evolution of pa

91 A synthesis have enabled the manipulation of megabase genomes.

92 ive trait loci (cis-eQTL) mapping for this 2 megabase genomic region using postmortem human brain sam

93 overing a large genomic region (508 genes; 2 megabases; >60,000x raw depth) in a prospective study of

94 yndrome (22q11DS), the result of a 1.5- to 3-megabase hemizygous deletion on human chromosome 22, res

95 he human genome assembly correspond to multi-megabase heterochromatic regions composed primarily of t

96 Juxtaposition of megabase heterozygous and homozygous regions causes cros

97 Over megabases, homoplasy rates fluctuate 1.9-fold, peaking t

98 size from 125 bp (budding yeast) to several megabases (human).

99 arget activity within loops spanning up to 2 megabases implies involvement of linear tracking.

100 liar are deletions at the breakpoints, up to megabases in extent.

101 e cycles, generating amplicons more than 100 megabases in length that became trapped within interphas

102 he level of large chromosomal domains (0.5-5 megabases in mammals) within which replicons are activat

103 Gains and losses of hundreds of megabases in many chromosomes are typical of the changes

104 er the primary linkage peak (approximately 4 megabases in size).

105 romosome is estimated to be at least several megabases in size.

106 altered in 27 of 50 recurrent CNA regions <5 megabases in size.

107 ng from single modified DNA bases to several megabases in the case of heterochromatic histone modific

108 essive zones (range, 0.35 approximately 5.98 megabases), including a 14-gene cluster located on 16p11

109 ve; we found that allelic variation in a 0.3-megabase interval in the class I D locus confers substan

110 ltered vertical eye movements linked to a 11-megabase interval on 1p32.

111 yndromic uterine fibroids, we explored a two-megabase interval spanning FH in the NIEHS Uterine fibro

112 Four of these represent megabase inversions confirmed by long read sequencing.

113 incidence of approximately three lesions per megabase is preferentially repaired in the transcribed s

114 At intervals of more than three megabases it is nearly identical to a map built in Europ

115 our mutation-rate model likely operate on a megabase length scale.

116 At the sub-megabase level, we observed stochastic clusters of conta

117 Xi exhibits extremely large loops, up to 77 megabases long, called "superloops." DXZ4 lies at the an

118 emporal changes in accessibility both across megabase-long AgR loci and locally at the recombination

119 locus, human chromosome 17q21.31, contains a megabase-long inversion polymorphism, many uncharacteriz

120 These linked-reads also generate megabase-long phased blocks and provide a cost-effective

121 NP-A binding sites are identified within the megabase-long, repetitive alpha-satellite DNAs at each c

122 vidual chromosomes, and specific segments at megabase (Mb) and kilobase (kb) resolutions of single av

123 ut 60%-70% of individuals with the typical 3 megabase (Mb) deletion from LCR22A-D have congenital hea

124 (HSY) and its X counterpart, yielding an 8.1-megabase (Mb) HSY pseudomolecule, and a 3.5-Mb sequence

125 irless skin of the extremities (3 and 14 per megabase (Mb) of genome), intermediate in those originat

126 d that targeted deletion in mice of the 0.11 megabase (mb)-long minimal deleted region (MDR) encompas

127 a targeted sequencing method for generating megabase (Mb)-scale haplotypes with short reads.

128 and accurate genome with a contig N50 of >15 megabases (Mb) and concordance of 99.997%, substantially

129 connecting anchor loci that may be dozens of megabases (Mb) apart, as well as inter-chromosomal links

130 hundreds of tandem duplications of up to 10 megabases (Mb) in size.

131 ransfer of bacterial genomes as large as 1.8 megabases (Mb) into yeast under conditions that promote

132 infestans genome, which at approximately 240 megabases (Mb) is by far the largest and most complex ge

133 in the biosphere: 5.3 x 1031 (+/-3.6 x 1031) megabases (Mb) of DNA.

134 Analysis of approximately 3.7 megabases (Mb) of genomic sequence, including 0.87 Mb of

135 iously mapped QTL, ranging from 47.4 to 64.4 megabases (Mb) on chromosome 7.

136 are being produced, going from the initial 1 Megabases (Mb) resolution to the current 10 Kilobases (K

137 omosome sequence generated here comprises 30 megabases (Mb).

138 p to 1421 genes with a total coverage of 5.5 Megabases (Mb).

139 complex phenotypes can be linked to long (>1-megabase [Mb]) runs of homozygosity (ROHs) detectable by

140 e polymorphism (SNP) arrays, we mapped a 1.3 megabase minimally deleted region including only the rep

141 Within the 2.7-megabase mouse Igh locus, V(D)J recombination is regulat

142 gher TMB, plateauing at 10 or more mutations/megabase (mut/Mb).

143 tumor mutational burden (TMB) >=10 mutations/megabase (mut/Mb)] and larotrectinib/entrectinib (NTRK f

144 Here we present analysis of the 363 megabase nuclear genome of the blood fluke.

145 es in patient transcriptomes occurs within 1 megabase of 78 novel gene fusions that function as centr

146 Laboratory mice with over half a megabase of DNA upstream of their Myc gene removed still

147 ble to predict >90% of target genes within 1 megabase of eQTLs.

148 genes expected based on number of genes per megabase of genome explains the observed density suggest

149 We assess >1 megabase of sequence in the vicinity of two essential tr

150 cer-trapping strategy in mice to scan a half-megabase of the 8q24 gene desert encompassing the prosta

151 M activation is not amplified by H2AX across megabases of chromatin to induce global signaling and re

152 tion of rare and common variants in over 300 megabases of coding sequence.

153 quencing) technologies, we examined over 100 megabases of DNA from amplified extracts, revealing unbi

154 n of the ancestral human genome, we identify megabases of DNA lost in different human lineages and pi

155 somatic mutations across approximately 1,800 megabases of DNA representing 1,507 coding genes from 44

156 oligonucleotides encoding approximately 2.5 megabases of DNA, which is at least 50 times larger than

157 Plant and animal centromeres comprise megabases of highly repeated satellite sequences, yet ce

158 Human centromeres are defined by megabases of homogenous alpha-satellite DNA arrays that

159 and amino acids to the incorporation of many megabases of human DNA.

160 ancers interconnected in some instances over megabases of linear chromatin.

161 We detect 4 megabases of novel sequence, encoding 11 new transcripts

162 he genetic interactions are located within 5 megabases of regions of known physical chromosome intera

163 ch to map the genomic locations of almost 20 megabases of sequence unlocalized or missing from the cu

164 Most animals and plants have megabases of tandem repeats at their centromeres, unlike

165 gregate, we recovered 1.34 gigabases and 303 megabases of the Neandertal and Denisovan genome, respec

166 enome reduced in size by nearly 8%, with 1.1 megabases of the synthetic genome deleted, inserted, or

167 with alleles that are highly divergent (15.1 megabases of the total genome size of 61.1 megabases).

168 uality reference genome (contig N50 of 15.78 megabases) of the maize small-kernel inbred line, which

169 ds with random errors, we assembled 99% (244 megabases) of the Oropetium genome into 625 contigs with

170 , DNA content increased by approximately 250 megabases, often representing a substantial fraction of

171 ysis, we mapped the Tsk2 gene mutation to <3 megabases on chromosome 1.

172 troduce H3K9me3 at hundreds of loci spanning megabases on human chromosome 19 and simultaneously trac

173 repeat satellite III (SAT III), which spans megabases on the X chromosome of Drosophila melanogaster

174 omarkers Associated to Structural Ensembles (MEGABASE), on odd-numbered chromosomes, we predict the s

175 These 177 high-confidence CNVRs cover 28.1 megabases or approximately 1.07% of the genome.

176 Our method identified events of 10 megabases or greater occurring in as little as 16% of th

177 umina exon and RNA sequencing revealed a 1.2-megabase pair deletion encompassing the 27- and 50-kD ga

178 asts and erythroblasts the folding of 10-160-megabase pair engineered chromosome regions consisting o

179 rases, which are primarily located on a 0.89-megabase pair plasmid.

180 ected indels ranging from 10 base pairs to 1 megabase pair that are difficult to detect via a single

181 GCRs, including balanced translocations and megabase-pair inversions.

182 We construct megabase-pair scale haplotypes for individual chromosome

183 romosomes, and infer loops averaging 0.8-1.0 megabase pairs (Mb) in early prophase and extending to 1

184 a from three human genomes and recover 33-79 megabase pairs (Mb) of duplications in which approximate

185 esidues, we were able to sequence 70 and 0.4 megabase pairs (Mbp) nuclear DNA of the Forbes' Quarry a

186 ter than the reference genome and that 420.2 megabase pairs of common repeats and 99.1% of validated

187 re typically arranged in an array that spans megabase pairs of DNA.

188 ing control region is the promoter for a one megabase paternal transcript encoding the ubiquitous pro

189 mutations averaged two to six mutations per megabase per cell, similar to that seen in many cancers,

190 Finally, we identified very large (over one megabase), rare SVs in 3.9% of samples, and estimate tha

191 The large megabase receptor loci undergo 3D changes in their struc

192 The disease gene mapped to a less than 2-megabase recessive locus at 12q21.33 with a logarithm of

193 A several megabase region at the "distal" end of the mouse IgH loc

194 usted multivariate linear analyses in the 40-megabase region encompassing the linkage peak were condu

195 lti into N. vitripennis and mapped to an 0.9 megabase region of chromosome 1.

196 ssociation mapping across an approximately 4 megabase region of the xMHC using a validated panel of s

197 by epistasis between the gene NDP and a ~2.8-megabase region on chromosome 18 with suppressed recombi

198 Hemizygous deletion of a 1.5- to 3-megabase region on chromosome 22 causes 22q11.2 deletion

199 We identified a 3-megabase region on human chromosome 21 containing 6 cand

200 ygous deletion of mouse chromosome 11B3, a 4-megabase region syntenic to human 17p13.1, produces a gr

201 gments, and 4 J(H) segments within a several megabase region.

202 TMB was calculated across a 1.14-megabase region; TMB-high was defined as >=20 mutations/

203 f ICF1-iPSC methylomes also identifies large megabase regions of CG hypomethylation typically localiz

204 kaemia (ALL) with recurrent amplification of megabase regions of chromosome 21 (iAMP21).

205 ng hybridization-based purification of multi-megabase regions with sequencing on the Illumina Genome

206 of chromosome 2H in a physical region of 1.3 megabases relative to the barley cv Morex reference asse

207 chromosomes fold at length scales beyond one megabase remains obscure relative to smaller-scale foldi

208 organization of chromatin in the nucleus at megabase resolution.

209 omes sequenced to date, totaling 921 and 999 megabases, respectively.

210 ome sequences within the linkage region (4.8 megabases) revealed missense mutation c.591C>A p.Glu197A

211 by the observation that the mutation rate at megabase scale and the local mutational patterns jointly

212 fferent epigenetic states at the kilobase-to-megabase scale, a length scale that is directly relevant

213 omosomes maintain domain organization at the megabase scale, but show variable cell-to-cell chromosom

214 At the sub-megabase scale, chromosomes form topologically associati

215 At the megabase scale, the chromatin conformation is consistent

216 methylated regions from the kilobase to the megabase scale.

217 gineering genomes from the nucleotide to the megabase scale.

218 ndependent of CTCF and can bridge sites at a megabase scale.

219 How Xist spreads silencing on a 150-megabases scale is unclear.

220 Several transgenic events contained megabase-scale arrays of introduced DNA mixed with genom

221 Analysis of SNP variation revealed megabase-scale blocks of sequence divergence among curre

222 ers of genes that promote reprogramming, and megabase-scale chromatin domains spanned by H3K9me3, inc

223 We report locus-specific disintegration of megabase-scale chromosomal conformations in brain after

224 th scales, ranging from single base pairs to megabase-scale chromosomal domains, and discuss the emer

225 brains, suggesting that previously reported megabase-scale CNVs in neurons arise at later stages of

226 proach that allows for reliable detection of megabase-scale CNVs in single somatic cells.

227 ng data to construct sequence scaffolds with megabase-scale contiguity ordered into chromosomal pseud

228 Megabase-scale copy number variants (CNVs) can have prof

229 that 13 to 41% of neurons have at least one megabase-scale de novo CNV, that deletions are twice as

230 iPSCs share megabase-scale differentially methylated regions proxima

231 y genetic polymorphisms that act in cis upon megabase-scale DNA segments.

232 that accurately predicts genome folding from megabase-scale DNA sequence.

233 e or repressed chromatin states, up to multi-megabase-scale domains associated with nuclear positioni

234 revealed that chromosomes are organized into megabase-scale domains that demarcate active and inactiv

235 ated across cancer types are concentrated in megabase-scale domains that occur near the telomeres and

236 (1) Megabase-scale genomic domains rich in ZIC2 peaks and ge

237 y, we assign genetic aberrations to specific megabase-scale haplotypes generated from whole-genome se

238 ing from thousands of single base changes to megabase-scale path reorganizations, gap closures, and l

239 ools uses the barcoded aligned reads and the Megabase-scale phase blocks to determine haplotypes of S

240 aneuploid regions), loss of heterozygosity, megabase-scale phased haplotypes often spanning entire c

241 spects of genome instability-specifically, a megabase-scale rearrangement underlying two genomic diso

242 indings reveal considerable variation in the megabase-scale recombination landscape among recently di

243 expression of clusters of genes embedded in megabase-scale regions marked with H3K36me2 and that con

244 Aberrant L1 integrations can delete megabase-scale regions of a chromosome, which sometimes

245 repressed by MeCP2 are often located within megabase-scale regions of high non-CG methylation that c

246 by MeCP2, but also enriched within extended megabase-scale regions surrounding MeCP2-repressed genes

247 estimated haplotypes to characterize mosaic megabase-scale structural mutations in 31,100 GWA study

248 show that 2% of individuals carry ultra-rare megabase-scale structural variants, nearly half of which

249 Mammalian genomes are organized into megabase-scale topologically associated domains (TADs).

250 akpoint subdivision of the X chromosome with megabase-scale X segments borne on Y chromosomes.

251 can delineate large runs of homozygosity (at megabase scales) and produce a reliable confidence inter

252 associated with gene expression variation at megabase scales.

253 enetically identical with the Y, harboring a megabase segment that is missing from the X.

254 While the total copy number of large multi-megabase segments can be derived from such data, importa

255 overy by allowing fine mapping to only a few megabases, significantly decreasing the number of potent

256 y used to assemble genetic constructs in the megabase size range, and has previously been used to tra

257 in seven species of Timema, we found that a megabase-size "supermutation" has deleted color loci in

258 an chromosomes, centromeric regions comprise megabase-size arrays of 171 bp alpha-satellite DNA monom

259 the transient opening of heterochromatin at megabase-size differentially accessible domains (DADs).

260 A in a single cell and to randomly partition megabase-size DNA strands into multiple nanoliter compar

261 n sample groups, and uncover the presence of megabase-size placenta hypomethylated domains.

262 the conservation of coordinately replicated megabase-sized "replication domains" punctuated by origi

263 ome organization, including segregation into megabase-sized active and inactive compartments, and par

264 eres of Arabidopsis thaliana are composed of megabase-sized arrays of a 178-bp satellite repeat.

265 yotes, centromeres are typically composed of megabase-sized arrays of satellite repeats that evolve r

266 most widely used for preparing high-quality megabase-sized DNA from divergent organisms.

267 ve successfully used to prepare high-quality megabase-sized DNA from hundreds of plant, animal, fish,

268 Megabase-sized DNA is crucial to modern genomics researc

269 f-renewing cells by inducing derepression of megabase-sized gene domains harboring downstream effecto

270 We identify large, megabase-sized local chromatin interaction domains, whic

271 though re-formation rates vary greatly, many megabase-sized loops recovered in under an hour, consist

272 g (GIPS) to selectively capture and sequence megabase-sized portions of a mutant genome.

273 CISMR (CRISPR-mediated isolation of specific megabase-sized regions of the genome), which enables us

274 Cen2, Cen3, Cen5, Cen7, and Cen8) contained megabase-sized satellite repeat arrays that are unique t

275 to perform targeted isolation of contiguous megabase-sized segments of the genome.

276 o establish regulatory fine structure within megabase-sized topologically associated domains.

277 that binds hermaphrodite Xs and establishes megabase-sized topologically associating domains (TADs).

278 Megabase-sized, complex, repetitive regions of genomes a

279 an initial analysis of the approximately 730-megabase Sorghum bicolor (L.) Moench genome, placing app

280 Y chromosomes of Drosophila contain multi-megabase stretches of satellite DNA repeats and a handfu

281 cleotide variants (SNVs; average of 11.2 per megabase), structural variants (SVs; average of 46), or

282 esults in reduced DCC binding across several megabases surrounded by topologically associating domain

283 te a variant of Escherichia coli with a four-megabase synthetic genome through a high-fidelity conver

284 an adjacent 'gene desert' of approximately 2 megabases that contains the long non-coding RNA gene PVT

285 xpectedly, UCYN-A has a reduced genome (1.44 megabases) that is structurally similar to many chloropl

286 in the genome of these lymphomas was one per megabase, there were a tremendous number of copy number

287 rearrangements ranging in size from several megabases to a few hundred base pairs can be generated b

288 that, for genomes spanning approximately 100 megabases to approximately 10 gigabases, errors become i

289 As genome size changes from megabases to gigabases, we predict that regularity of RO

290 ers, from multi-megabase compartments to sub-megabase topologically associating domains (TADs) and su

291 conformation capture (Hi-C) has revealed sub-megabase topologically associating domains (TADs), which

292 +/- 1.953 (mean +/- sd.; N = 7) variants per megabase (v/mb) for samples including synonymous variant

293 ion in recombination rates (centimorgans per megabase) was observed along the X chromosome, ranging f

294 th eve enhancers across distances of several megabases, when the communication is mediated by Homie.

295 At the intermediate scale of kilobases to megabases, which encompasses the sizes of genes, gene cl

296 In most species, we identify striking megabase-wide regions, where nucleotide diversity is les

297 NPs) nominally associated with EEM in the 40-megabase window encompassing the linkage peak.

298 ersonii, which consists of approximately 830 megabases with an N50 of 44,303 bp anchored to 12 chromo

299 of regions ranging from tens of kilobases to megabases with the same basic protocol.

300 adscale recombination rate (centimorgans per megabase) within M. musculus.