ライフサイエンスコーパス: megakaryocyte progenitor

1 mbocytosis with increased megakaryocytes and megakaryocyte progenitors.

2 fects in erythroid cells and an expansion of megakaryocyte progenitors.

3 nt cells, including GATA-1s-expressing fetal megakaryocyte progenitors.

4 l embryos harbor definitive erythroid or any megakaryocyte progenitors.

5 initive waves, each containing erythroid and megakaryocyte progenitors.

6 ect on erythroid, granulocyte-macrophage, or megakaryocyte progenitors.

7 ell cycling in BaF3/Mpl cells and in primary megakaryocyte progenitors.

8 FU-MK, we developed a new protocol to purify megakaryocyte progenitors.

9 e a pure population of primary CD41-positive megakaryocyte progenitors.

10 t reveals induction of PU.1 and expansion of megakaryocyte progenitors.

11 rly and functionally distinct populations of megakaryocyte progenitors.

12 cripts and a maturation of SL-MkPs and other megakaryocyte progenitors.

13 y, we demonstrate that bipotential erythroid-megakaryocyte progenitor and CD150(+)CD9(hi)endoglin(lo)

14 ion environment with subsequent expansion of megakaryocyte progenitors and immature megakaryoblasts,

15 (Mpl) support survival and proliferation in megakaryocyte progenitors and in BaF3 cells engineered t

16 Fetal and neonatal megakaryocyte progenitors are hyperproliferative compare

17 growth factor which causes proliferation of megakaryocyte progenitors as well as induces megakaryocy

18 At this time, the number of megakaryocyte progenitors begins to decline in the yolk

19 pulations: "Pre-MEP," enriched for erythroid/megakaryocyte progenitors but with residual myeloid diff

20 e that survivin is necessary for survival of megakaryocyte progenitors, but is not required for polyp

21 critical role in commitment of the erythroid-megakaryocyte progenitor by modulating the level of the

22 ripotent stem cells to generate immortalized megakaryocyte progenitor cell lines that can be cryopres

23 erate (approximately sevenfold) expansion of megakaryocyte progenitor cells (colony-forming unit-mega

24 permethylation within CG islands of HSCs and megakaryocyte progenitor cells (MKPs) in patients with D

25 ulate the growth, development, and ploidy of megakaryocyte progenitor cells and platelet production i

26 Here, megakaryocyte progenitor cells are genetically engineere

27 Marrow megakaryocyte progenitor cells averaged 3.3 (range, 0.4

28 353 +/- 255 x 10(6)/kg; P = .04); (3) marrow megakaryocyte progenitor cells fourfold (from a mean of

29 SDF-1alpha on migration and proliferation of megakaryocyte progenitor cells in vitro.

30 ntegrity and stability of mRNAs derived from megakaryocyte progenitor cells remain poorly quantified

31 nt analysis (PCA) to identify and enrich for megakaryocyte progenitor cells that are capable of self-

32 ification, classification, and enrichment of megakaryocyte progenitor cells that are produced during

33 characteristics that can be used to isolate megakaryocyte progenitor cells using standard flow cytom

34 product of megakaryocyte number and volume), megakaryocyte progenitor cells, circulating levels of en

35 through stimulation of the proliferation of megakaryocyte progenitor cells, to support of the matura

36 ciencies in the numbers of megakaryocytes or megakaryocyte progenitor cells.

37 inflammation-induced activation of stem-like megakaryocyte progenitor cells.

38 nificantly greater number of IL-3-responsive megakaryocyte progenitors CFU (CFU-MK) and an increase i

39 asia, we investigated the effect of SDF-1 on megakaryocyte progenitors (colony-forming units-megakary

40 mine the expression of the CXCR4 receptor on megakaryocyte progenitors (colony-forming units-megakary

41 counting for the increased cell death in the megakaryocyte progenitor compartment.

42 CD41(+) megakaryocyte progenitors derived from these cells expre

43 This enrichment strategy distinguishes megakaryocyte progenitors from other lineage-committed c

44 cription factors preferentially expressed in megakaryocyte progenitors (Gata2 and Zfpm1) and decrease

45 The age-induced megakaryocyte progenitors have a profoundly enhanced cap

46 P1 knock-in megakaryocyte progenitors have reduced proliferative cap

47 KO mice show significantly increased megakaryocyte progenitors in the BM by FACS analysis and

48 ng that survivin is required for survival of megakaryocyte progenitors in vivo.

49 rders that selectively affect fetal/neonatal megakaryocyte progenitors, including the thrombocytopeni

50 n of both the lympho-myeloid and the erythro-megakaryocyte progenitors is dependent on Ikaros and its

51 We found that SDF-1alpha potently induced megakaryocyte progenitor migration and significantly enh

52 ion profile closely resemble that of primary megakaryocyte progenitors (MkPs) and they further differ

53 A sub-fraction of myelofibrosis megakaryocyte progenitors (MkPs) are transcriptionally s

54 The embryonic megakaryocyte progenitors (MKPs) in the E11.5 FL were id

55 s, Abcg4 was highly expressed in bone marrow megakaryocyte progenitors (MkPs).

56 nd mouse hematopoietic stem cells (HSCs) and megakaryocyte progenitors (MkPs).

57 d for >100 days, implying culture renewal by megakaryocyte progenitors (MKPs).

58 l embryos had normal primitive erythroid and megakaryocyte progenitor numbers and kinetics between em

59 ceivable that the affected patients harbor a megakaryocyte progenitor pool whose apoptotic activity i

60 We define a bipotential erythroid-megakaryocyte progenitor population, the CD150(+)CD9(lo)

61 TP-RO mRNA sequences significantly inhibited megakaryocyte progenitor proliferation.

62 and/or TPO hastened myeloid, erythroid, and megakaryocyte progenitor recovery compared to vehicle co

63 Surprisingly, fetal NF-E2-deficient megakaryocyte progenitors showed reduced proliferation p

64 Mature megakaryocytes, but not megakaryocyte progenitors, specifically bound fibrinogen

65 We conclude that in BaF3/Mpl cells and megakaryocyte progenitors, thrombopoietin-induced phosph

66 -4 (VLA-4)-mediated localization of CXCR4(+) megakaryocyte progenitors to the vascular niche, promoti

67 n and LY294002 were blocked in G(1), whereas megakaryocyte progenitors treated with thrombopoietin an

68 Megakaryocyte progenitors were elevated, especially in t

69 ABCG4 is highly expressed in megakaryocyte progenitors, where it promotes cholesterol

70 lopment of leukocytes, with the exception of megakaryocyte progenitors, which are significantly reduc

71 In contrast, reduced numbers of megakaryocyte progenitors with restricted proliferative

72 port that chemokine-mediated interactions of megakaryocyte progenitors with sinusoidal bone marrow en