ライフサイエンスコーパス: meibomian gland

1 mine whether neurotransmitters influence the meibomian gland.

2 expression of almost 400 genes in the human meibomian gland.

3 y multiple changes in gene expression in the meibomian gland.

4 progesterone modulate gene expression in the meibomian gland.

5 progesterone regulate gene expression in the meibomian gland.

6 he expression of numerous genes in the mouse meibomian gland.

7 ression of more than 1590 genes in the mouse meibomian gland.

8 n of IGF-1 action in epithelial cells of the meibomian gland.

9 in the sex-related differences of the mouse meibomian gland.

10 r role in the sex-related differences of the meibomian gland.

11 significant impact on gene expression in the meibomian gland.

12 ression of more than a thousand genes in the meibomian gland.

13 ility and quality of meibum, and drop-out of meibomian glands.

14 ctopic row of hair follicles in place of the Meibomian glands.

15 r and ectopic cilia formed at the expense of Meibomian glands.

16 dant in the eyelid, which contains wax-laden meibomian glands.

17 ant second row of eyelashes arising from the meibomian glands.

18 me; and (2) trophic effects on sebaceous and Meibomian glands.

19 ed for the maintenance of both sebaceous and meibomian glands.

20 ed to the basement membranes of acini of the meibomian glands.

21 ing TH, CGRP, and SP were more sparse in the meibomian glands.

22 te associated changes of the lid margins and meibomian glands.

23 with the expressibility and the drop-out of meibomian glands.

24 automated lipid expression (Lipiflow) of the Meibomian glands.

25 n managing OSD arising from disorders of the meibomian glands.

26 ent of OSD that arises from disorders of the meibomian glands.

27 ands and contributes to the formation of the meibomian glands.

28 erior segment of the eye, and the absence of meibomian glands.

29 anterior segment defects and the absence of meibomian glands.

30 d bulbar conjunctiva, corneal epithelium and meibomian glands.

31 terations in the lipid content of the rabbit meibomian gland; 19-nortestosterone treatment modulated

32 that 1) as previously reported, mice lacked meibomian glands; 2) >80% developed corneal lesions such

33 Numerous nerve fibers near the meibomian gland acini were immunoreactive for NPY and VI

34 Secretions that are produced by meibomian glands (also known as meibum) are a major sour

35 Immortalized human meibomian gland and conjunctival epithelial cells were c

36 ting stress showed hyperproliferation of the meibomian gland and ductal dilation suggesting a marked

37 he expression of numerous genes in the mouse meibomian gland and that many of these genes are involve

38 ment and the commonest was an anomaly of the meibomian glands and lacrimal drainage system defects.

39 in staining, TBUT, osmolarity, and secreting meibomian glands and meibum quality were also seen.

40 The meibomian glands and other structures within the lid mar

41 o impaired vitamin A metabolism, loss of the meibomian glands and recurrent eyelid trauma.

42 nic eyelid closure as well in development of meibomian glands and the anterior segment of the eye.

43 The meibomian glands and the lipid layer thickness had the s

44 exists in the epithelial cell nuclei of rat meibomian glands and, in addition, whether androgen defi

45 nance of primary epithelial cells from human meibomian glands and, second, to immortalize these cells

46 anterior eye segment defects, absence of the meibomian glands, and defects in the semilunar cardiac v

47 al and neutral lipid fractions of the rabbit meibomian gland; and androgens did not appear to influen

48 within acinar epithelial cell nuclei of rat meibomian glands; androgen deficiency was associated wit

49 in anatomical and functional aspects of the meibomian gland are seen in SJS.

50 Both the lipid layer and meibomian glands are not affected.

51 ontent, and fatty acid profile of the rabbit meibomian gland, as well as the appearance of the tear f

52 luding hypertrophic salivary, sebaceous, and meibomian glands, as well as enhanced squamous tumorigen

53 essenger RNA is also present in lacrimal and meibomian glands, as well as in a number of other tissue

54 lopment and maturation of both sebaceous and meibomian glands, as well as in the formation and compos

55 B presenting over seventeen months including meibomian gland assessment using a recognized classifica

56 Meibography imaging assessed for severe meibomian gland atrophy ( grade 2 atrophy; 1 eyelid on v

57 Meibography grading of meibomian gland atrophy and acini appearance, and slit-l

58 Meibomian gland atrophy and deterioration of meibum qual

59 omarker positivity was assessed in 16 severe meibomian gland atrophy cases after being found relevant

60 All severe meibomian gland atrophy cases had ocular symptoms/signs

61 In 16 severe meibomian gland atrophy cases, 62.5% tested positive for

62 In severe meibomian gland atrophy cases, 86% reported 4 hours of d

63 Patients with known meibomian gland atrophy causes or poor-quality meibograp

64 was not significantly associated with severe meibomian gland atrophy vs controls (P = .34, right-eye;

65 ctronic screen use is associated with severe meibomian gland atrophy.

66 Aged heterozygotes also showed meibomian gland atrophy.

67 , 11 years; 49% female): 17 cases had severe meibomian gland atrophy; 24 controls had insignificant g

68 biomarker positivity in children with severe meibomian gland-atrophy.

69 redness, tear volume, anterior blepharitis, meibomian gland capping) and tear inflammatory cytokine

70 Consistent with this, we show that human Meibomian gland carcinoma exhibits increased Hh signalin

71 t cell cohesion is maintained differently in meibomian gland cells and indicate that Ecad is importan

72 hair growth after shaving and also enlarged meibomian glands, consistent with a nearly 80% reduction

73 The findings also show that the human meibomian gland contains several highly expressed genes

74 stemic, T-cell-dependent process that causes meibomian gland damage and induces a robust form of ocul

75 rmore, corneal stroma neovascularization and meibomian gland degeneration were examined by immunohist

76 subbasal corneal nerve inhomogeneity (SCNI), Meibomian gland density and inhomogeneity (MGD, MGI), an

77 Murine lacrimal, harderian and meibomian glands develop from the prospective conjunctiv

78 ents with dry eye who had rosacea-associated meibomian gland disease (MGD) or Sjogren's syndrome (SS)

79 Study groups included meibomian gland disease (MGD), aqueous tear deficiency (

80 hology, causes, and ocular surface impact of meibomian gland disease (MGD), as well as its relationsh

81 5 patients with DE, including subgroups with meibomian gland disease (MGD), Sjogren's syndrome (SS) a

82 ological changes are one of the key signs of meibomian gland disease (MGD).

83 ormal and 33 subjects with tear dysfunction (meibomian gland disease [n = 11], aqueous tear deficienc

84 ffective treatment for OSD that results from meibomian gland disease.

85 The meibomian gland dropout area (meiboscore) was calculated

86 Ocular rosacea is associated with marked meibomian gland dropout in both eyelids, with the lower

87 mmatory mediators (HIF-1alpha and MMP-2) and meibomian gland dropout in OSAS.

88 positively correlated with the total eyelid meibomian gland dropout values (r = 0,208, p < 0,05 and

89 Lower and total eyelid meibomian gland dropout values of the participants in th

90 The upper eyelid meibomian gland dropout values were higher in the severe

91 Meibomian gland dropout was evaluated with a tomograph a

92 ibum from normal donors (Mn) and donors with meibomian gland dysfunction (Md) by (1)H-NMR spectroscop

93 )H-NMR spectra of meibum from 39 donors with meibomian gland dysfunction (Md) were compared to meibum

94 is less ordered than meibum from donors with meibomian gland dysfunction (Md).

95 rading of clinical variables associated with meibomian gland dysfunction (MGD) in real-time examinati

96 It has been generally accepted that meibomian gland dysfunction (MGD) is a leading cause of

97 Meibomian gland dysfunction (MGD) is a major cause of ev

98 Meibomian gland dysfunction (MGD) is a primary cause of

99 Meibomian gland dysfunction (MGD) is the leading cause o

100 Meibomian gland dysfunction (MGD) is the leading cause o

101 Meibomian gland dysfunction (MGD) is the major cause of

102 Meibomian gland dysfunction (MGD) is the most common cau

103 Meibomian gland dysfunction (MGD) may be the leading cau

104 h regular eyelid shampoo on the treatment of meibomian gland dysfunction (MGD) signs and symptoms.

105 and the abnormalities of these glands cause Meibomian gland dysfunction (MGD) which is responsible f

106 The treatment of moderate to severe meibomian gland dysfunction (MGD) with oral doxycycline

107 lated to be necessary for the development of meibomian gland dysfunction (MGD), a common form of chro

108 ure changes in human meibum composition with meibomian gland dysfunction (MGD).

109 ned from 41 normal donors and 51 donors with meibomian gland dysfunction (MGD).

110 Twelve patients also had noninflamed meibomian gland dysfunction (MGD).

111 (TBUT), Schirmer's test, tear osmolarity and meibomian gland dysfunction (MGD).

112 of all DED cases are caused by some form of Meibomian gland dysfunction (MGD).

113 or the treatment of dry eye disease owing to meibomian gland dysfunction (MGD).

114 sted an association between dyslipidemia and meibomian gland dysfunction (MGD).

115 f depression has been found in patients with meibomian gland dysfunction (MGD); however, specific con

116 njunctivitis (OR: 3.76, 95% CI: 1.33-10.63), meibomian gland dysfunction (OR: 4.45, 95% CI: 1.9-10.40

117 oma, retinal vein occlusion, conjunctivitis, meibomian gland dysfunction and blepharitis, between pat

118 oma, retinal vein occlusion, conjunctivitis, meibomian gland dysfunction and blepharitis.

119 conjunctival staining, tear osmolarity, and meibomian gland dysfunction at baseline, 6 months, and 1

120 Their pathogenic potential in meibomian gland dysfunction is discussed herein.

121 Meibomian gland dysfunction is the most common etiology

122 investigating the linkage of lid changes and meibomian gland dysfunction may shed new lights on the p

123 Meibum lipid compositional changes with meibomian gland dysfunction reflect changes in hydrocarb

124 time, Oxford Schema, Schirmer's test I, and meibomian gland dysfunction testing.

125 time, corneal and conjunctival staining, and meibomian gland dysfunction, all in both eyes, and a com

126 its associated lacrimal gland inflammation, meibomian gland dysfunction, and severe dry eye.

127 igating ocular surface pathologies involving meibomian gland dysfunction, blepharitis, corneal or con

128 s, accompanied by tear hyperosmolarity, mild meibomian gland dysfunction, reduced BUT, mucus filament

129 Restasis) may also have a positive effect on meibomian gland dysfunction, the other main form of dry

130 gesting a pathogenic role in blepharitis and meibomian gland dysfunction.

131 e pathology of the ocular surface resembling Meibomian gland dysfunction.

132 luorescein corneal stain, and assessment for meibomian glands dysfunction (MGD) were carried out.

133 In aqueous-deficient dry eye (ADDE) and Meibomian-gland dysfunction (MGD), compositional changes

134 Immortalized human meibomian gland epithelial (SLHMG) cells were examined f

135 g), and promoted lipid accumulation in human meibomian gland epithelial cells (about 2-fold increase

136 ied the regulation of cell cohesion in human meibomian gland epithelial cells (HMGECs).

137 the lipogenesis and differentiation of human meibomian gland epithelial cells (HMGECs).

138 port the hypothesis that IGF-1 acts on human meibomian gland epithelial cells and may explain why tre

139 It was possible to isolate viable human meibomian gland epithelial cells and to culture them in

140 Meibomian gland epithelial cells are essential in mainta

141 The results show that human meibomian gland epithelial cells may be isolated, cultur

142 demonstrate that EGF and BPE stimulate human meibomian gland epithelial cells to proliferate.

143 N, SETTING, AND MATERIAL: Immortalized human meibomian gland epithelial cells were cultured in the pr

144 To test our hypotheses, immortalized human meibomian gland epithelial cells were cultured with or w

145 shes the differentiation and adipogenesis of meibomian gland epithelial cells, and both mTOR complexe

146 eir agonists influence the function of human meibomian gland epithelial cells.

147 ication of IGF-1 and growth hormone to human meibomian gland epithelial cells.

148 tiation (e.g., lipid accumulation), of human meibomian gland epithelial cells.

149 its a pronounced lipid accumulation in human meibomian gland epithelial cells.

150 ammatory mediator and protease expression in meibomian gland epithelial cells.

151 , keratinization, and inflammation, in human meibomian gland epithelial cells.

152 icant, time-dependent proliferation of human meibomian gland epithelial cells.

153 d attenuates cell survival pathways in human meibomian gland epithelial cells.

154 chirmer test results without anesthesia, and meibomian gland examination.

155 eyelid margin measurements, meibum quality, meibomian gland expressability, ocular surface disease i

156 tablish reliable morphologic measurements of meibomian glands for evaluating MGD severity.

157 Because lipid production was unaltered in meibomian glands from Dsg3-deficient mice, we establishe

158 Meibomian glands from intact, androgen- and/or placebo-t

159 esis in the study was that androgens control meibomian gland function, regulate the quality and/or qu

160 ells and indicate that Ecad is important for meibomian gland function.

161 x, Ocular Surface Staining, Schirmer I test, Meibomian gland functionality in 757 patients (1514 eyes

162 This study was conducted to identify meibomian gland genes that may promote the development a

163 Therapeutically, anti-inflammatory therapy, meibomian gland heating and expression, and scleral cont

164 ilm osmolarity, inflammatory biomarkers, and meibomian gland imaging.

165 ty has no obvious effect on the histology of meibomian glands in male or female mice.

166 l injections (IVI) on the ocular surface and meibomian glands in patients with neovascular age-relate

167 eous glands (SGs) or in free SGs such as the Meibomian glands in the eyelids.

168 upper lids, total mebioscore, percentage of meibomian glands in upper and lower lids, first non-inva

169 upper lids, total meiboscore, percentage of meibomian glands in upper and lower lids, NIV-BUT of the

170 thetic preganglionic neurons that project to meibomian gland-innervating ganglion cells are located i

171 n, platinum segment insertion, correction of meibomian gland inversion (MGI), full-thickness skin gra

172 hypothesis that the androgen control of the meibomian gland involves the regulation of gene expressi

173 plications, including the destruction of the meibomian glands, irregularity of the eyelid margin, and

174 The findings show that the meibomian gland is an androgen target organ and that and

175 In prior work, it has been found that the meibomian gland is an androgen target organ, that androg

176 A striking characteristic of the human meibomian gland is its rich sensory, sympathetic, and pa

177 in sebocytes, and attenuates SGs and eyelid meibomian glands, leading to corneal ulceration.

178 al abnormalities are not solely dependent on meibomian gland lipid secretion.

179 thickness (LLT); tear meniscus height (TMH); meibomian gland loss (MGL); tear osmolarity.

180 In conclusion, evaluation of meibomian gland loss and distortion are valuable complem

181 Meibomian gland loss was significantly higher in both up

182 nd lower), 160 (65%) eyelids revealed severe meibomian gland loss.

183 est new approaches to treat aging-associated Meibomian gland loss.

184 glands were significantly enlarged, and the meibomian glands malformed.

185 Neither specific aqueous nor meibomian gland measurements were significantly correlat

186 mark stem cells that play a critical role in Meibomian gland (MG) development and homeostasis, howeve

187 rneal epithelial disruption and lower eyelid meibomian gland (MG) dropout, adjusted for age and sex (

188 elial sodium channel (ENaC) subunits exhibit meibomian gland (MG) dysfunction.

189 Meibomian gland (MG) formation is employed as a model wh

190 staining score (according to Oxford scale), meibomian gland (MG) loss rates of lower and upper eyeli

191 ation of dyslipidemia and its treatment with meibomian gland (MG) morphologic changes by standardized

192 o conclusive information about the impact of meibomian gland (MG) morphology in tear film physiology

193 esence of corneal subepithelial fibrosis and meibomian gland (MG) orifice metaplasia were recorded.

194 Age, gender, Schirmer's test, meibomian gland (MG) related parameters, lipid layer thi

195 evelopment, homeostasis and pathology of the Meibomian gland (MG).

196 mpact of Elovl3 inactivating mutation on the Meibomian glands (MG) and conjunctiva of mice.

197 Meibomian glands (MG) are large sebaceous glands located

198 Meibum-a lipid secretion that is produced by Meibomian glands (MG) in a process termed meibogenesis-p

199 osynthesis of FAlc and FAld in mammals using Meibomian glands (MG) of wild-type (WT) and Sdr16c5/Sdr1

200 ime (TBUT), Tear Film Meniscus Height (TMH), Meibomian glands (MG), and Lipid Layer Thickness (LLT) w

201 result in a marked enlargement of the mouse Meibomian glands (MGs) and sebaceous glands, respectivel

202 Lipids secreted by the meibomian glands (MGs) of the eyelids are essential to t

203 Exocrine meibomian glands (MGs) play a central role in the ocular

204 e physiology of the mouse ocular surface and Meibomian glands (MGs).

205 e modeling to identify relationships between Meibomian gland morphological features and subject demog

206 77%, 76%, and 86% accuracies for predicting Meibomian gland morphological features, subject age, and

207 Meibomian gland obstruction and meibocyte depletion are

208 The paper studied the meibomian gland of 30 RA cases referred by the Rheumatol

209 The meibomian glands of rhesus and cynomolgous monkeys are r

210 scosity could alter secretion of lipids from meibomian glands, or tear-film stabilization properties

211 Plugging and capping of meibomian gland orifices, foamy tear, glands expressibil

212 on between symptoms and global, aqueous, and meibomian gland parameters.

213 lities in the fur texture and the absence of meibomian glands prompted us to evaluate other epidermal

214 eal staining, tear breakup time, Schirmer's, meibomian gland quality, orifice plugging, lid vasculari

215 Many pathologies can disrupt function of meibomian glands, ranging from congenital to acquired ca

216 d in the search documented an improvement in meibomian gland-related OSD after treatment with these a

217 expression in cutaneous sebaceous vs eyelid Meibomian glands remain to be established.

218 Meibomian glands secrete lipid-rich meibum, which preven

219 meibomian ducts (P = 0.005) and a pathologic meibomian gland secretion (P = 0.001).

220 These findings also suggest that meibomian gland secretion is under the control of divers

221 e Disease Index, tear film breakup time, and meibomian gland secretion quality.

222 Human meibomian gland secretions (meibum) were analyzed by ele

223 lar components of the lipids in normal human meibomian gland secretions (meibum).

224 tty acids and the fatty acid amides in human meibomian gland secretions by using electrospray mass sp

225 he production, secretion, and/or delivery of meibomian gland secretions to the ocular surface, the go

226 Aging-related Meibomian gland shrinkage may result in part from stem c

227 eral corneal, or bulbar conjunctival stroma; meibomian glands; skin; retina-choroid; or episcleral re

228 mal development of both sebaceous glands and meibomian glands, specialized sebaceous glands of the ey

229 The identities and niche of Meibomian gland stem cells and the signals controlling t

230 This study highlights the need to evaluate meibomian gland structure and function in patients with

231 ith mechanical expression of lipids from the meibomian glands successfully treats dry eye symptoms an

232 The response of the meibomian gland to desiccating stress also suggest that

233 In this study, only the meibomian gland was affected among the anterior segment

234 sebaceous carcinomas apparently derived from Meibomian glands were also negative (n = 12).

235 Meibomian glands were isolated and processed for RNA ext

236 Meibomian glands were obtained from adult, age-matched w

237 Meibomian glands were obtained from orchiectomized mice

238 Meibomian glands were obtained from young adult, ovariec

239 Human meibomian glands were removed from lid segments after su

240 ring a transgene for the Eda-A1 isoform, but meibomian glands were restored little if at all.

241 In the eyelid, Meibomian glands were uniformly negative for 15-lipoxyge

242 However, its specific role in the Meibomian gland, where lipid metabolism is significant,

243 airs arising inappropriately from the eyelid meibomian glands-which is evident from birth.

244 lts indicate that aging mice show dropout of meibomian glands with loss of gland volume and a forward

245 Meibomian glands within the eyelid are important for the