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1 les with little hysteresis observed (1.9 J/G meibum).
2  in normal human meibomian gland secretions (meibum).
3 lting characteristics of normal and abnormal meibum.
4 a proper balance in the lipid composition of meibum.
5 better understand lipid composition in human meibum.
6 teresis increased many fold compared to pure meibum.
7 uch higher rigidity and hysteresis than pure meibum.
8  phase transitions in bulk samples of bovine meibum.
9 pecies as the major amphiphilic component of meibum.
10 ich made them the largest group of lipids in meibum.
11  glycerides, and cholesteryl esters in human meibum.
12 ns of a set of training NMR spectra of human meibum.
13                                              Meibum-a lipid secretion that is produced by Meibomian g
14 anges in the overall chemical composition of meibum after the treatment, which implies no direct effe
15 f the levels of cholesteryl esters in infant meibum and Md suggests that the relative amounts of thes
16 udying the mechanisms of the biosynthesis of meibum and modeling various pathologies of human ocular
17 efore, we characterized, for the first time, meibum and sebum of Sdr16c5/Sdr16c6-null (DKO) mice usin
18 d to alterations in the lipid composition of meibum and severe ocular and MG abnormalities that repli
19             As Cer and FC can be elevated in meibum and the tear film because of certain pathologic p
20 ydrogel contact lenses and, potentially, the meibum and/or tear film.
21 on, Marx line, expressibility and quality of meibum, and drop-out of meibomian glands.
22 nation and collision-induced dissociation of meibum, and lipid standards were used to identify lipid
23                                   We studied meibum architecture and its relation to bulk and interfa
24                     Wax esters (WE) of human meibum are one of the largest group of meibomian lipids.
25  produced by meibomian glands (also known as meibum) are a major source of lipids for the ocular surf
26 viscosity and elasticity has implications in meibum behavior in the tear film.
27 om that of Caucasians, individual samples of meibum collected from ethnic Asian population living in
28 re, the purpose of this study was to compare meibum collected from humans and three typical laborator
29  spectra of human meibum indicate that human meibum collected from normal donors (Mn) is less ordered
30 gher Marx line score, and a lower quality of meibum compared with mite-free patients.
31 on-induced dissociation of this species from meibum, compared with an oleamide standard, confirmed it
32  suggests that the relative amounts of these meibum components alone are unlikely to be responsible f
33                                   An altered meibum composition represents the primary cause of evapo
34                In this study, the changes in meibum composition were measured in search of markers of
35 is tool was used to measure changes in human meibum composition with meibomian gland dysfunction (MGD
36                                        Their meibum contains less CH(3) and C horizontal lineC groups
37             Subtypes were patients with high meibum delivery (hypersecretory and nonobvious MGD) and
38 etory and nonobvious MGD) and those with low meibum delivery (hyposecretory and obstructive MGD).
39 ers and ocular symptoms than those with high meibum delivery, indicating the pivotal role of meibum s
40  side comparison of the rabbit and the human meibum demonstrated their vast differences.
41   Composed primarily of a mixture of lipids, meibum exhibits a range of melt temperatures.
42  distortion was negatively correlated to the meibum expressibility (r = -0.53; p < 0.001) and DESL (r
43 Disease Index questionnaire, meibum quality, meibum expressibility, lid margin abnormality, ocular st
44 and controls; examined their correlations to meibum expressibility, quality, and DESL.
45                      Clinical tests included meibum expression and quality, tear film break-up time,
46 M, LipiView, Schirmer's 1, corneal staining, Meibum Expression score (MES, 0-3), and Meibum Quality s
47 were divided into 4 subtypes of MGD based on meibum expression, meibum quality, and MG loss on meibog
48  presence of micron-scale inhomogeneities in meibum films at higher temperatures.
49 mian gland dysfunction (Md) were compared to meibum from 33 normal donors (Mn).
50                          (1)H-NMR spectra of meibum from 39 donors with meibomian gland dysfunction (
51                                Compared with meibum from adolescents and adults, meibum from infants
52 from normal donors (Mn) is less ordered than meibum from donors with meibomian gland dysfunction (Md)
53 w the mechanical properties and structure of meibum from healthy subjects depend on temperature.
54 red with meibum from adolescents and adults, meibum from infants and children contains less CH(3) and
55 ion of possible compositional differences in meibum from normal donors (Mn) and donors with meibomian
56 progressively higher amounts of CER or FC to meibum had a strong impact on the rigidity, stability, a
57                             Mass analysis of meibum in an acidic chloroform-methanol solution in posi
58 ved between three-dimensional melting of dry meibum in bulk and the two-dimensional melting in MLF at
59  to a 8 C drop in the melting temperature of meibum in E3hom mice, and increased its fluidity.
60 ponent analyses of infrared spectra of human meibum indicate that human meibum collected from normal
61 sruption occurs, the quality and quantity of meibum is altered, with a negative impact on the ocular
62  interfacial rheology measurements show that meibum is extremely viscous and highly elastic.
63                 The lipid composition of the meibum isolated from Awat2(-/-) mice revealed the absenc
64  to detect differences in the composition of meibum, it is promising that NMR can be used as a diagno
65       Despite the critical importance of the meibum, its biosynthetic pathways and the roles of indiv
66         The resulting increased viscosity of meibum led to the dilation of the meibomian ducts, and t
67 waxes, cholesteryl esters, and glycerides in meibum lipid (ML).
68        It may be that a change in the normal meibum lipid composition and conformation causes this ab
69                                              Meibum lipid compositional changes with meibomian gland
70 ad to these effects is strong aggregation of meibum lipids with FC or Cer that leads to the formation
71 4% and 40 +/- 2%, respectively, of the total meibum lipids.
72 elective changes in the lipid composition of meibum, making E3hom mice instrumental in studying the m
73                                         Bulk meibum melted in a narrower temperature range and showed
74 h disease may alter the temperature at which meibum melts.
75                         The major changes in meibum of DKO mice included abnormal accumulation of sho
76 d margin abnormality scores (P = .0059), and meibum quality (P = .0002) in the statin group during fo
77 s of upper eyelid meiboscores (P = .046) and meibum quality (P = .046) were noted in the nonstatin gr
78 lit lamp examination for signs of changes in meibum quality and MG lid morphologic features.
79                      MGD leads to changes in meibum quality and quantity that can cause evaporative d
80 Meibomian gland atrophy and deterioration of meibum quality continued in the long term among particip
81 ing, Meibum Expression score (MES, 0-3), and Meibum Quality score (MQS, 0-3).
82 molarity, and secreting meibomian glands and meibum quality were also seen.
83  subtypes of MGD based on meibum expression, meibum quality, and MG loss on meibography images (meibo
84 spite of improvement in both eyes, scores of meibum quality, conjunctival hyperemia, corneal and conj
85 eal staining and eyelid margin measurements, meibum quality, meibomian gland expressability, ocular s
86  Ocular Surface Disease Index questionnaire, meibum quality, meibum expressibility, lid margin abnorm
87 , corneal staining, fluorescein TBUT, ME, or meibum quality.
88   A set of WE and CE standards was spiked in meibum samples for ionization efficiency determination a
89  (mumol/mg) for each of 51 WEs and 31 CEs in meibum samples was determined.
90                                              Meibum samples were collected by using a soft-squeezing
91                             Intact lipids in meibum samples were detected by direct infusion electros
92               Major neutral lipid classes in meibum samples were quantitatively profiled by ESI-MS an
93                                          The meibum samples were studied by direct infusion electrosp
94 DED share similar characteristics, including meibum secretion and morphology, but MGD patients coexis
95 bum delivery, indicating the pivotal role of meibum secretion in ocular surface health that should be
96 ss of the terpenoids could be deleterious to meibum since they exhibit a plethora of mostly positive
97 ads to the formation of smaller particles of meibum surrounded by a thinner layer of FC or Cer.
98  saturation could be the critical feature in meibum that stabilizes tears in infants.
99 he production, secretion, and/or delivery of meibum to the ocular surface.
100                   If the melt temperature of meibum was altered significantly from disease-induced co
101                                              Meibum was obtained from 41 normal donors and 51 donors
102                                              Meibum was obtained from healthy volunteers.
103        To determine if non-DES/non-MGD Asian meibum was significantly different from that of Caucasia
104 pressing liquid, and quality of the improved meibum were assessed before and 6 months after MiBoFlo.
105 ative levels of cholesteryl esters in infant meibum were comparable to those in Md.
106                         Interfacial films of meibum were highly viscoelastic at 17 degrees C, but as
107 Abnormalities in the chemical composition of meibum were linked to widespread ocular pathologies-dry
108            Human meibomian gland secretions (meibum) were analyzed by electrospray quadrupole time-of
109 primary amide, is a predominant component of meibum when examined by electrospray mass spectrometry.
110 ng in situ and, mostly, de novo a secretion (meibum), which is composed of a complex mixture of homol
111  were shown to comprise 41 +/- 8% (wt/wt) of meibum, which made them the largest group of lipids in m
112          Meibomian glands secrete lipid-rich meibum, which prevents tear evaporation.
113 obed by small angle x-ray scattering of bulk meibum, which showed evidence of a majority crystalline
114                      A series of mixtures of meibum with Cer or FC (mixed MLF) taken in different rat
115             The analysis of intact lipids in meibum with direct infusion ESI-MS/MS analysis has the a

 
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