ライフサイエンスコーパス: meiosis

1 er centromere and kinetochores during oocyte meiosis.

2 ed SC structures that are maintained late in meiosis.

3 the same order as genome size - as occurs in meiosis.

4 ic DSB controls respond to aneuploidy during meiosis.

5 structure their kinetochores when they enter meiosis.

6 the recombination of sex chromosomes during meiosis.

7 tial for autophagy to regulate budding yeast meiosis.

8 Cin8 and Kip3 together are indispensable for meiosis.

9 per separation of chromosomes in mitosis and meiosis.

10 _4 is the critical state between mitosis and meiosis.

11 y and faithful chromosome segregation during meiosis.

12 are essential to homologous recombination in meiosis.

13 ochromatin formation in spermatocytes during meiosis.

14 is essential for kinetochore organization in meiosis.

15 with special focus on the critical state of meiosis.

16 forms between homologous chromosomes during meiosis.

17 e-microtubule attachments in yeast and mouse meiosis.

18 o be transmitted transgenerationally through meiosis.

19 chromosome dynamics during C. elegans female meiosis.

20 ced X-linked gene expression before entering meiosis.

21 portant feature of an evolved autotetraploid meiosis.

22 MSCI permits the timely progression of male meiosis.

23 hat RBMXL2 controls splicing patterns during meiosis.

24 ide potential insights into the evolution of meiosis.

25 ilure to accomplish a metabolic shift during meiosis.

26 grounds and in mutants incapable of entering meiosis.

27 w that Arabidopsis APC8 is required for male meiosis.

28 tensive germ cell loss because of incomplete meiosis.

29 ion to define the function of AtAPC8 in male meiosis.

30 Mendelian segregation of chromosomes during meiosis.

31 and SCML2 concordantly regulate genes during meiosis.

32 diates homologous chromosome synapsis during meiosis.

33 rs from vegetative cells or cells undergoing meiosis.

34 ese key events during Caenorhabditis elegans meiosis.

35 re-evaluated the role of this cyclin during meiosis.

36 divisions, it is imperative that they finish meiosis.

37 PRDM9 is not required for completion of male meiosis.

38 nce of this central regulator of mitosis and meiosis.

39 ng factor (MPF; CDK1-cyclin A/B) activity in meiosis.

40 ed the developmental program into maize male meiosis.

41 interrogating the complexities of mammalian meiosis.

42 responsible for regulating CDK functions in meiosis.

43 absence of synapsis in the initial stages of meiosis.

44 coding Rme1p, a transcriptional repressor of meiosis.

45 ts transiently with APPL1 and Akt2 to induce meiosis.

46 direct chromosome segregation in mitosis and meiosis.

47 strand break repair, replication stress, and meiosis.

48 ), which is, in part, caused by an arrest at meiosis.

49 omatin remodeling factor can regulate oocyte meiosis.

50 e maintenance of chromosome integrity during meiosis.

51 l for accurate chromosome segregation during meiosis.

52 gainst selfish elements that manipulate fair meiosis.

53 RAD51, performs strand exchange in mammalian meiosis.

54 is access to recombination hot spots during meiosis.

55 ation and recombination in an autotetraploid meiosis.

56 recombination of genetic information during meiosis.

57 hromosome to microtubules during mitosis and meiosis.

58 e ability of frozen-thawed oocytes to resume meiosis.

59 berosum, face a variety of challenges during meiosis.

60 ruitment dictates the fate decision to enter meiosis.

61 ensive reorganization of kinetochores during meiosis.

62 r of XCI-which are silenced after entry into meiosis.

63 stages of prophase I and metaphase I during meiosis.

64 solution of double Holliday junctions during meiosis.

65 t well understood, particularly in mammalian meiosis.

66 reased IME1 expression, and earlier onset of meiosis.

67 ves GSC maintenance and occurs before oocyte meiosis.

68 on, and homologous chromosome pairing during meiosis.

69 676dup (p.Trp226LeufsTer4) in M1AP, encoding meiosis 1 associated protein, in three unrelated men.

70 eving accurate chromosome segregation during meiosis [1, 2].

71 bine in order to segregate accurately during meiosis(1).

72 uring prometaphase and metaphase I of female meiosis [9, 10].

73 high aneuploidy rate observed during female meiosis, a leading cause of infertility and congenital d

74 st strains for which IME4 is dispensable for meiosis, a natural polymorphism in the RME1 promoter red

75 aintain the integrity of rDNA borders during meiosis, a process distinct and independent from its kno

76 ferentiates into two distinct domains before meiosis: a steroidogenic core (the female medulla), over

77 ressed transcripts normally present in early meiosis after a delay; thus, the germinal transcriptiona

78 Meiosis, although essential for reproduction, is also va

79 chiasma, AXL seems to be dispensable during meiosis, although its absence slightly alters chiasma di

80 been suggested that during C. elegans female meiosis, anaphase is mediated by a kinetochore-independe

81 al morphogenesis with the landmark events of meiosis and demonstrates that cells can developmentally

82 between both genes regarding two processes: meiosis and DNA repair.

83 Recombination is critical to meiosis and evolution, yet many aspects of the physical

84 in Symbiodiniaceae, cytological evidence of meiosis and fertilisation are however yet to be observed

85 of chromosome missegregation in human female meiosis and for predicting the outcomes of assisted repr

86 e model to deplete EWSR1 before the onset of meiosis and found that absence of EWSR1 causes meiotic a

87 ortant for governing spindle assembly during meiosis and mitosis by releasing the inhibitory effects

88 ution to phenotypic variation, especially in meiosis and mitosis, as well as to more incisively model

89 is conserved among ascomycetes and regulates meiosis and pseudohyphal growth in Saccharomyces cerevis

90 ds to reduced numbers of germ cells, delayed meiosis and reduced fecundity in adult offspring.

91 romosome segregation during both mitosis and meiosis and regulate chromosomal and genomic dosage resp

92 are highly expressed in testis, enriched for meiosis and RNA interference functions and are frequentl

93 ubules during Drosophila melanogaster female meiosis and suggest that catalytically active Polo is a

94 proteins associated with distinct stages of meiosis and syngamy.

95 effect on recombination is not restricted to meiosis and that CDKG1 is also required for normal level

96 2 is a crucial regulator of MPF functions in meiosis and that its paralog, CKS1, must be excluded fro

97 ers occur via the class II pathway in female meiosis and that this could be explained by reduced DNA

98 ncomplete demethylation of key regulators of meiosis and transposable elements.

99 ransitions during the yeast metabolic cycle, meiosis, and amino acid starvation; however, this effect

100 ur naturally during immune cell development, meiosis, and at telomeres as well as from aborted topois

101 into the differences between male and female meiosis, and crossover patterning.

102 dial germ cells, epigenetic reprogramming or meiosis, and demonstrate that oocyte growth and lineage-

103 p metaphase cells, in the pachytene stage of meiosis, and in interphase nuclei.

104 o the premature separation of chromosomes at meiosis, and the simultaneous disruption of PANS1 and PA

105 regate with high fidelity during mitosis and meiosis, and yet specific aneuploidies can be adaptive d

106 Meiosis- and RNAi-related genes often coamplify on recen

107 ation patterns of chromosomes in mitosis and meiosis are dictated in part by the kinetochores, the st

108 Using Xenopus oocyte meiosis as a well-established physiological readout of n

109 ut also on screening pathogenic mutations in meiosis-associated diseases.

110 f this approach by capturing male and female meiosis, asymmetric pollen division, movement of meiotic

111 y for recombination and synapsis during male meiosis at high ambient temperature.

112 propose that this mechanism is essential to meiosis because it buffers the high ambient concentratio

113 We unravel roles in regulating meiosis, beyond its enzymatic activity in poly(ADP-ribos

114 In meiosis, BRCA2 binds to MEILB2 to localize to DNA double

115 We show here that in meiosis, Bub3 is crucial for correction of attachment er

116 switch recombination or crossing-over during meiosis, but also present a threat to genome stability.

117 hat functional PRDM9 is required to complete meiosis, but despite its apparent importance, Prdm9 has

118 important for germ-cell progression through meiosis, but the extent to which androgens indirectly re

119 undant in oocytes, and its levels drop after meiosis, but unexpectedly, a significant fraction is pre

120 Maize heterochromatic knobs cheat female meiosis by forming neocentromeres that bias their segreg

121 in spermatocytes and its functional roles in meiosis by generating the first male germ cell-specific

122 suggest that stabilization of allopolyploid meiosis can be enhanced by loss of a key meiotic recombi

123 these data because the natural randomness in meiosis can be viewed as a high-dimensional randomized e

124 A failure to maintain meiosis can result in highly aberrant polyploid cells, w

125 pe may compromise germ cell progression into meiosis, causing cortical germ cells to remain in an imm

126 tion, extracellular matrix formation, oocyte meiosis, cholesterol metabolism, glycolysis/gluconeogene

127 During meiosis, chromosomes adopt a specialized organization in

128 Asymmetric division in female meiosis creates selective pressure favoring selfish cent

129 In meiosis, crossover (CO) formation between homologous chr

130 During meiosis, crossover recombination connects homologous chr

131 refore been unclear why, in mammalian oocyte meiosis, cyclin B1 destruction begins before chromosome

132 The genome of the meiosis-defective pathogen Candida albicans encodes an R

133 The capacity to undergo meiosis defines vertebrate germ cells, yet mechanisms dr

134 With these unique features, this meiosis-directed Y1H system is particularly suited for c

135 We developed a high-throughput meiosis-directed yeast one-hybrid system using the Magic

136 During meiosis, DNA double-strand breaks (DSBs) are induced as

137 During meiosis, DNA double-strand breaks (DSBs) enter interhomo

138 During meiosis, DNA double-strand breaks undergo interhomolog r

139 ota is essential for the progression through meiosis during spermatogenesis and germline stem cell ma

140 , discovery of genetic mechanisms regulating meiosis, embryo and endosperm development have facilitat

141 fically, at gamete formation and conception, meiosis ensures random allocation to the offspring of on

142 How cells stay committed to finishing meiosis, even in the presence of a mitosis-inducing sign

143 ages beyond the commitment point will finish meiosis, even with nutrient addition.

144 as some of its targets are functional during meiosis, FgAma1 may target other proteins that function

145 this study, we found that the initiation of meiosis following spermatogenesis was not affected and t

146 Despite the necessity of oocyte meiosis for successful reproduction, how these spindles

147 el captures several known features of female meiosis, for instance, the maternal age effect on PSSC.

148 n that specifically colocalizes with TR-1 in meiosis, forming long drawn out neocentromeres.

149 In eukaryotic meiosis, generation of haploid gametes depends on the fo

150 As a critical stage of oocytes development, meiosis has been extensively studied, yet how chromatin

151 Aurora B governs telomere separation during meiosis has remained unknown.

152 During meiosis, homologous chromosomes pair and recombine, enab

153 yers involved in two meiotic cell divisions, meiosis I (MI) and meiosis II (MII).

154 Homologous chromosome segregation during meiosis I (MI) in mammalian oocytes is carried out by th

155 10 and Smk1 form an inhibited complex during meiosis I (MI).

156 otic errors, such as nondisjunction (NDJ) in meiosis I and meiosis II, and premature separation of si

157 ost germ cells were arrested at metaphase of meiosis I and no mature sperm were detected in epididymi

158 yeast Aurora B localizes at telomeres during meiosis I and promotes telomere separation independently

159 Ultimately, these defects result in meiosis I arrest before homologous chromosome segregatio

160 ected chromosomes from nondisjunction at the meiosis I cell division.

161 , we show that Wapl is required for accurate meiosis I chromosome segregation, predominantly releases

162 hat the centering mechanism is maintained in meiosis I despite chromosome movement in the opposite di

163 and eventual segregation of homologs in the meiosis I division.

164 IKIN, suggests that kinase coordination by a meiosis I regulator may be a general feature in the esta

165 st one crossover and no DSBs remain prior to meiosis I segregation.

166 de of spindle bipolarization is required for meiosis I to prevent chromosome segregation errors.

167 nderwent more-frequent nondisjunction during meiosis I, and others showed more meiosis II segregation

168 In meiosis I, sister kinetochores are paired and oriented t

169 Reductional meiosis I, where maternal and paternal chromosomes (homo

170 s are required for spindle bipolarization in meiosis I.

171 atids (PSSC) and reverse segregation (RS) in meiosis I.

172 s II errors among eggs affected by errors in meiosis I.

173 of kinetochore attachment to microtubules in meiosis I.

174 the pattern of chromosome segregation during meiosis I.

175 2A involved in chromosome congression during meiosis I.

176 Migration of meiosis-I (MI) spindle from the cell center to a sub-cor

177 o meiotic cell divisions, meiosis I (MI) and meiosis II (MII).

178 Consequently, some cells fail to undergo meiosis II and form dyads, while some, as they progress

179 ells, we detected chromosome breakage in the meiosis II cells.

180 atterns, including an increased frequency of meiosis II errors among eggs affected by errors in meios

181 ewise, condensin activity is nonessential in meiosis II for telomere and chromosome arm separation.

182 ation suggests that the occurrence of NDJ in meiosis II is associated with the ploidy status of an eg

183 ion during meiosis I, and others showed more meiosis II segregation failures.

184 uch as nondisjunction (NDJ) in meiosis I and meiosis II, and premature separation of sister chromatid

185 In meiosis II, Aurora B controls KT-MT attachment but appea

186 Lastly, we found that during meiosis II, autophagy degrades Rim4, an amyloid-like tra

187 dyads, while some, as they progress through meiosis II, cause a defect in chromosome integrity.

188 In contrast, in meiosis II, cytoplasm that contains upregulated factors

189 mologs) segregate, is followed by equational meiosis II, where sister chromatids separate.

190 revealed that autophagy inhibition prevents meiosis II-specific expression of Clb3 and leads to the

191 f chromosome segregation between mitosis and meiosis II.

192 curring at distinct genomic intervals during meiosis in all species examined [3-10].

193 g chromosome segregation in both mitosis and meiosis in animals.

194 While examining meiosis in cin8Delta kip3Delta cells, we detected chromo

195 tion forks, and cross over chromatids during meiosis in eukaryotes.

196 tated ploidy cycling prior to a conventional meiosis in eukaryotes.

197 Acentrosomal meiosis in oocytes represents a gametogenic challenge, r

198 l) or proliferate and differentiate to enter meiosis in response to retinoic acid (RA).

199 d found that CKS1 can compensate for CKS2 in meiosis in vivo, but homozygous embryos arrested develop

200 osine (m(6)A) methyltransferase required for meiosis in yeast, acts by methylating a site in the 3' U

201 LKs) have numerous roles in both mitosis and meiosis, including functions related to chromosome segre

202 ng rare chromosome mis-segregation events in meiosis, including instances of whole-genome equational

203 ts characteristics indicative of an abortive meiosis, including slight enlargement of spermatocytes p

204 ell populations, which limits the studies of meiosis initiation and progression at a higher resolutio

205 ls, which offers new information not only on meiosis initiation and progression but also on screening

206 n shown that Wdr62 is required for germ cell meiosis initiation in mice, and the majority of male ger

207 Meiosis initiation is a crucial step for the production

208 We found that meiosis initiation occurs as early as E12.5 and the clus

209 To dissect the process of meiosis initiation, we investigated the transcriptional

210 During meiosis, interhomolog recombination produces crossovers

211 information between parental chromosomes in meiosis is an integral process for the creation of gamet

212 ons. In budding yeast, the decision to enter meiosis is controlled by nutrient and mating-type signal

213 tion of chromosome segregation during oocyte meiosis is of vital importance to mammalian reproduction

214 A central feature of meiosis is pairing of homologous chromosomes, which occu

215 Chromosome segregation during male meiosis is tailored to rapidly generate multitudes of sp

216 Meiosis is the specialized cell division during which pa

217 Meiosis is the specialized cell division that generates

218 some distribution at anaphase of mitosis and meiosis is triggered by separase, an evolutionarily cons

219 are selectively activated in the context of meiosis is unclear.

220 efore, the role of PP2A in C. elegans female meiosis is unknown.

221 f PIWI proteins mostly expressed during male meiosis, is crucial for piRNA biogenesis, post-transcrip

222 riate mitosis-like chromosome segregation in meiosis leads to gametes with incorrect chromosome numbe

223 nary discoveries of the polyploidization and meiosis-like ploidy reduction process in cancer cells, s

224 During meiosis many eukaryotes utilize a two-recombinase pathwa

225 -resolution in vivo maps of RPA and RAD51 in meiosis, mapping their binding locations and lifespans t

226 Before entry into meiosis, meiotic SEs are preprogrammed in mitotic sperma

227 tly increases chromosome misalignment at the meiosis metaphase I plate, and causes chromosome mis-seg

228 hen genome editing to substitute mitosis for meiosis (MiMe)(3,4) is combined with the expression of B

229 However, during meiosis, more than 200 DSBs are generated deliberately,

230 Ndc80 turnover is also tightly regulated in meiosis: Ndc80 degradation is active in meiotic prophase

231 In summary, this study indicates that the meiosis of first wave spermatogenesis and the following

232 ologue pairing and initiate recombination at meiosis onset.

233 ally interact with 16-cell cysts to regulate meiosis, oocyte development, and cyst morphological chan

234 y reduced DNA double-strand breaks in female meiosis, paralleling the observed reduction in synaptone

235 rain kinase MBK-2, which is activated during meiosis, phosphorylates Katanin at multiple serines.

236 Meiosis poses unique challenges because two rounds of ch

237 Mutations that arise at male meiosis produce kernels with concordant mutant phenotype

238 irreversibly committed to the completion of meiosis program.

239 analogous stage of G2/M is repurposed during meiosis prophase to promote interactions between homolog

240 ed to assemble sufficient pre-MPF for timely meiosis re-entry and progression.

241 Meiosis recombines genetic variation and influences euka

242 Figla deficiency dysregulates expression of meiosis-related genes (e.g. Sycp3, Rad51, Ybx2) and a va

243 pletion of Snf2h results in dysregulation of meiosis-related genes, which causes failure of maturatio

244 A distinct class of meiosis-related multi-copy Y genes independently co-ampl

245 artitioning of homologous chromosomes during meiosis relies on the coordinated execution of multiple

246 the mechanisms governing this initiation of meiosis remain poorly understood.

247 However, the role of the APC/C during plant meiosis remains largely unknown.

248 ut how these proteins collaborate to control meiosis remains poorly understood.

249 Orderly segregation of chromosomes during meiosis requires that crossovers form between homologous

250 Proper segregation during meiosis requires that homologs be connected by the combi

251 Faithful gamete formation through meiosis requires that kinetochores take on new functions

252 asynchrony of the transition from mitosis to meiosis results in heterogeneity in the female germ cell

253 of differentiation, potential regulators of meiosis, RNA turnover during spermatid differentiation,

254 The meiosis-specific alpha-kleisin cohesin subunit REC8 was

255 of Smk1 by Ssp2 is positively regulated by a meiosis-specific coactivator of the anaphase promoting c

256 and crossover precursors, removing different meiosis-specific cohesin complexes, which are individual

257 ds to both PRDM9 and pREC8, a phosphorylated meiosis-specific cohesin, in male meiotic cells.

258 Intriguingly, meiosis-specific genes are activated in C. neoformans an

259 novo circular minichromosomes revealed that meiosis-specific HORMA-domain proteins assemble into coh

260 Functional analyses of meiosis-specific interactors of MutLgamma-Exo1 identifie

261 yeast, Saccharomyces cerevisiae, to use the meiosis-specific kleisin, recombination 8 (Rec8), during

262 Smk1 is a meiosis-specific mitogen-activated protein kinase (MAPK)

263 of their composition and reveal mitosis- and meiosis-specific modules in the interaction networks.

264 olo kinase (Polo) is inhibited by the female meiosis-specific protein Matrimony (Mtrm) in a stoichiom

265 r their differential regulation involves the meiosis-specific recombination proteins Hop2 and Mnd1, w

266 y two molecular events: the establishment of meiosis-specific SEs via A-MYB (MYBL1), a key transcript

267 MEIOB, a meiosis-specific ssDNA-binding protein, regulates early

268 The synaptonemal complex (SC) is a meiosis-specific structure formed between homologous chr

269 assembly of the synaptonemal complex (SC), a meiosis-specific tripartite structure that maintains sta

270 Furthermore, two conserved 'meiosis-specific' factors play central roles in CCL as S

271 G RNA in primary spermatocytes 'primes' post-meiosis steps for sperm maturation.

272 the meiotic A-type cyclin TARDY ASYNCHRONOUS MEIOSIS (TAM).

273 key events taking place during prophase I of meiosis that are required for achieving proper chromosom

274 In H2ax-Y142A meiosis, the establishment of DDR signals on the chromos

275 ngeless homologs are selected against during meiosis, the incidence may be much higher in developing

276 During meiosis, the kinetochore is restructured to accommodate

277 Thus, in meiosis, the requirements for Aurora B are distinct at c

278 ly in the two sexes (heterochiasmy); in male meiosis, they are restricted to the termini of all four

279 strated a new function of WDR62 in germ cell meiosis, through its interaction with CEP170.

280 undergo extensive chromatin remodelling post-meiosis, thus acquiring an active chromatin state and sp

281 , they suggest a pattern of progression from meiosis to a more mitotic state in producing sperm.

282 PLKs require specific regulation during meiosis to control those processes.

283 elfish centromeres exploit asymmetric female meiosis to drive non-Mendelian segregation in their favo

284 Sexually reproducing organisms use meiosis to generate haploid gametes and faithfully trans

285 undergo dynamic changes after the mitosis-to-meiosis transition and have been subject to evolutionary

286 After the mitosis-to-meiosis transition in male mice, specific ERVs function

287 ermline gene expression after the mitosis-to-meiosis transition.

288 ection and DSB repair intermediates in mouse meiosis using a method that maps blunt-ended DNA after s

289 we show that EWSR1, a protein whose role in meiosis was not previously clarified in detail, binds to

290 atpat21-1 was caused by upstream defects in meiosis, we assessed meiotic progression in pollen mothe

291 Upon functional analyses during mouse male meiosis, we demonstrated that HELLS is required for PRDM

292 stion in budding yeast, in which cells enter meiosis when starved.

293 et Katanin for proteasomal degradation after meiosis, whereas phosphorylation at the other sites only

294 city of X-chromosomal gene expression during meiosis, which is different from somatic cells.

295 the control of genetic recombination during meiosis, which leads to crossovers between chromosomes c

296 nsure accurate chromosome segregation during meiosis while creating novel allelic combinations.

297 one class, 24-nt phasiRNAs, coincident with meiosis, while a second class of 21-nt phasiRNAs are pre

298 of 1.29 x 10(-8) mutations per base pair per meiosis with a 95% confidence interval of [1.02 x 10(-8)

299 The Fgpal1 mutant was normal in meiosis with eight nuclei in developing asci but most as

300 During meiosis with two rounds of microtubule assembly-disassem