ライフサイエンスコーパス: meiotic

1 isolated premeiotic (0.2, 0.4, and 0.6 mm), meiotic (0.8, 1.0, and 1.4 mm), and postmeiotic (1.8 mm)

2 candidate binding partners of premeiotic and meiotic 24-nt phasiRNAs, respectively.

3 sses of premeiotic (21-nucleotides [nt]) and meiotic (24-nt) phased small interfering RNAs (phasiRNAs

4 to the two classes of premeiotic (21-nt) and meiotic (24-nt) phasiRNAs, previously described in maize

5 th a diploid variety, which likely indicates meiotic adaptation to the autotetraploid state.

6 ial detachment from the cell cortex, a known meiotic alteration to mitochondrial morphology.

7 he kinase Aurora B, is a master regulator of meiotic and mitotic processes that ensure the equal segr

8 spermatocytes suggesting a role for both in meiotic and post-meiotic germ cell RNA editing.

9 aneuploidies and 23 (31%) embryos possessed meiotic aneuploidies.

10 ylation of most 24-PHAS loci is increased in meiotic anthers of control plants but not in the ms23 an

11 siRNAs), which are exceptionally abundant in meiotic anthers of diverse flowering plants.

12 ilure to initiate MSCI is linked to complete meiotic arrest and elimination of germ cells; however, t

13 -exome sequencing in 58 men with unexplained meiotic arrest and identified the same homozygous frames

14 iosis and found that absence of EWSR1 causes meiotic arrest with decreased histone trimethylation at

15 ce, arguing for mtDNA turnover during oocyte meiotic arrest.

16 indings provide insight into the role of the meiotic axis in patterning recombination frequency withi

17 Thus, the meiotic BRCA2 complex is central in meiotic HR, and its

18 (DSBs) are introduced in the genome of each meiotic cell by the SPO11 protein.

19 hanges, including in genes that regulate the meiotic cell cycle and recombination.

20 Smarca5) plays a critical role in regulating meiotic cell cycle progression.

21 ion coinciding with oocyte re-entry into the meiotic cell cycle.

22 ein increases 4-fold during reentry into the meiotic cell cycle.

23 s important for endomembrane trafficking and meiotic cell cycle.

24 step for mouse oocytes to undergo asymmetric meiotic cell division.

25 Meiotic cell divisions are coordinated with sporulation

26 different molecular players involved in two meiotic cell divisions, meiosis I (MI) and meiosis II (M

27 nce errors during mitotic rather than during meiotic cell divisions.

28 Our study elucidates the mechanism by which meiotic cells modulate their kinetochore composition thr

29 inally, defects in Ndc80 turnover predispose meiotic cells to chromosome mis-segregation.

30 phorylated meiosis-specific cohesin, in male meiotic cells.

31 mitotic chromosome segregation patterns into meiotic cells.

32 e mechanisms of DSB processing and repair in meiotic chromatin.

33 chromatin states and is required to organize meiotic chromosome architecture and interhomolog recombi

34 The data uncover a network of meiotic chromosome axis and recombination proteins that

35 rotein SUN1, with a possible crucial role in meiotic chromosome behavior.

36 nation research and highlight constraints on meiotic chromosome configurations and chiasma frequencie

37 CED-3 in promoting germ cell proliferation, meiotic chromosome disjunction, egg shell formation, and

38 play widely conserved roles in orchestrating meiotic chromosome dynamics.

39 hin pericentromeres, COs are associated with meiotic chromosome missegregation.

40 ndent suppression of embryonic lethality and meiotic chromosome non-disjunction respectively, when se

41 Meiotic chromosome pairing between homoeologous chromoso

42 ion of distinct chromosome subdomains during meiotic chromosome remodeling.

43 P1, a balance that is essential for accurate meiotic chromosome segregation and timely anaphase onset

44 The role of the kinetochore during meiotic chromosome segregation in C. elegans oocytes has

45 Crossover recombination is critical for meiotic chromosome segregation, but how mammalian crossi

46 idisation (FISH) to differentiate individual meiotic chromosomes 1 and 2.

47 ning showed that MSH2 protein accumulates on meiotic chromosomes during prophase I, consistent with M

48 Crossovers must be properly placed along meiotic chromosomes for their accurate segregation.

49 Direct analogies with meiotic chromosomes suggest that the same effects could

50 of Holliday junctions or their precursors in meiotic chromosomes(4).

51 sis, asymmetric pollen division, movement of meiotic chromosomes, and unusual restitution mitosis in

52 chanism, the variable physical compaction of meiotic chromosomes, generates interindividual and cell-

53 conserved structure built between homologous meiotic chromosomes, is required for crossover formation

54 lished using this system on both mitotic and meiotic chromosomes.

55 ently reported AAA unfoldases, including the meiotic clade relative Vps4, and supports a model in whi

56 ental platform to investigate and manipulate meiotic CO control.

57 Using this approach, we query sufficiency in meiotic CO suppression, and identify Ctf19 as a mediator

58 expression of STAG3, a key component of the meiotic cohesin complex, via a non-canonical JAK/STAT pa

59 tes telomere separation independently of the meiotic cohesin Rec8.

60 fEVs and their potential roles in sustaining meiotic competence of cryopreserved oocytes.

61 hromosomes are a battleground for sexual and meiotic conflict.

62 obligate CO/chiasma and accounts for ~85% of meiotic COs, whereas the residual ~15% are consistent wi

63 a key regulatory factor in the formation of meiotic COs.

64 We found that the meiotic crescent MIC has a specific chromosome interacti

65 migration-may be sufficient to explain most meiotic crossing over in mice while also addressing long

66 hensive study of recombination rate (rate of meiotic crossing over) in two natural populations of Dro

67 dation as a fundamental mechanism underlying meiotic crossing over.

68 re, we review observations on two aspects of meiotic crossover control - crossover interference and r

69 Meiotic crossover frequency varies within genomes, which

70 To identify genetic variation that controls meiotic crossover frequency, we screened Arabidopsis acc

71 per homolog pair will be designated to form meiotic crossovers (COs), where reciprocal genetic excha

72 Meiotic crossovers facilitate chromosome segregation and

73 These mechanisms regulating meiotic crossovers may be conserved across species.

74 Meiotic crossovers result from homology-directed repair

75 vels directly correlate with the severity of meiotic defects.

76 y, the point mutant mice are fertile despite meiotic defects.

77 tegrity as germ cell nuclei progress through meiotic development and migrate for gametogenesis-proces

78 n SYCP3, the exposure to vinclozolin delayed meiotic differentiation from both in vitro- and in vivo-

79 investigating mitochondrial dynamics during meiotic differentiation in budding yeast, we sought to u

80 urvival strategies: mitotic proliferation or meiotic differentiation into a stress-resistant state.

81 res of mouse fetal ovaries from the onset of meiotic differentiation of germ cells (13.5 days post co

82 essed in testes, that is required for normal meiotic division and spermiogenesis.

83 id conceptions are thought to originate from meiotic division errors in the female germline, quantita

84 avior of homologous chromosomes at the first meiotic division is usually ensured by crossing over.

85 testes failed to acquire competence for the meiotic division phase.

86 promotes cellular states permissive for the meiotic division phase.

87 During prophase of the first meiotic division, cells deliberately break their DNA(1).

88 as in oocytes progressing through the first meiotic division.

89 between homologous chromosomes in the first meiotic division.

90 ween which are delineated by cell fusion and meiotic division.

91 chaotic chromosome segregation at the first meiotic division.

92 inding protein, Ssp2, upon completion of the meiotic divisions.

93 Moreover, meiotic DNA breaks and interhomolog crossovers preferent

94 le for PARG in coordinating the induction of meiotic DNA breaks and their homologous recombination-me

95 Following pre-meiotic DNA replication, we blocked autophagy by chemica

96 ween homologs at >200 sites originating from meiotic double-strand breaks (DSBs).

97 rs generated during the repair of programmed meiotic double-strand breaks must be tightly regulated t

98 ntify C > G as a mutagenic signature of male meiotic double-strand breaks on the X, which may result

99 chromosome 9 (162 Mb), and 53 Mb of the Ab10 meiotic drive haplotype.

100 f the TRKIN/TR-1 system is to facilitate the meiotic drive of the KINDR/knob180 system.

101 bination suppression, assortative mating and meiotic drive.

102 gregation to egg cells in a process known as meiotic drive.

103 The wtf4 gene is a meiotic driver in Schizosaccharomyces pombe that uses a

104 Srinivasa and Zanders provide an overview of meiotic drivers and the diverse mechanisms these genetic

105 Killer meiotic drivers are genetic parasites that destroy 'sibl

106 Meiotic drivers are parasitic loci that force their own

107 k empirically demonstrates the potential for meiotic drivers to shape the evolution of gametogenesis.

108 SPO11 targeting, and the ATM kinase controls meiotic DSB numbers.

109 JAK/STAT pathway, and consequently promotes meiotic DSB repair and homologous recombination.

110 section of DSB-adjacent DNA is a key step in meiotic DSB repair, but this process has remained unders

111 enrichment is associated with suppression of meiotic DSBs and crossovers at the chromosome and fine s

112 Here, we demonstrate the direct detection of meiotic DSBs and resection using END-seq on mouse sperma

113 Meiotic DSBs are generated by Spo11 and accessory DSB pr

114 If left unrepaired, meiotic DSBs can cause aneuploidy in gametes and comprom

115 Meiotic DSBs initiate homologous recombination (HR), whi

116 tion of mitotic enhancers and suppression of meiotic enhancers in the somatic and/or mitotic prolifer

117 key regulatory factors for both mitotic and meiotic enhancers, revealing a molecular logic for the c

118 while FBF-2 promotes both cell division and meiotic entry rates.

119 ssion of the master transcription factor for meiotic entry, IME1.

120 m cell dynamics: FBF-1 restricts the rate of meiotic entry, while FBF-2 promotes both cell division a

121 for mitotic growth but becomes critical upon meiotic entry.

122 ivision rate simultaneously with the rate of meiotic entry.

123 hromosome gain/loss outcomes that arise from meiotic errors, such as nondisjunction (NDJ) in meiosis

124 To understand the contributions of different meiotic errors, we fit our model to aneuploidy data from

125 Focusing on post-meiotic events, we characterise the temporal dynamics of

126 iotic gene expression to enable irreversible meiotic exit.

127 ed due to the absence of Su(Ste) piRNAs, and meiotic failures were observed.

128 ghts into the transcriptome features of peri-meiotic female germ cells, which offers new information

129 exchange (HE), which arises from compromised meiotic fidelity and generates genetically and phenotypi

130 the fitness costs of mutations that disrupt meiotic fidelity and, in some circumstances, can even ma

131 However, its meiotic function remains unknown.

132 Although genes related to meiotic functions were reported in Symbiodiniaceae, cyto

133 us, autophagy destroys a master regulator of meiotic gene expression to enable irreversible meiotic e

134 ssense variant S167L in HSF2BP, an essential meiotic gene.

135 Cryptococcal cells that activated their meiotic genes in mice were resistant to specific genotox

136 n addition, expression of key DNA repair and meiotic genes is altered when either AXR1 or AXL are abs

137 The identified QTL regions suggest candidate meiotic genes that could be manipulated in order to cont

138 Our findings support the idea that meiotic genes, in addition to their conventional roles i

139 ed that Snf2h regulates transcription of key meiotic genes, such as Prkar2b, by increasing its promot

140 e same host tissue but without activation of meiotic genes.

141 ggesting a role for both in meiotic and post-meiotic germ cell RNA editing.

142 all homozygous clonal lines were produced by meiotic gynogenesis and were verified as clonal and iden

143 diploid spermatogonia to clusters of 64 post-meiotic haploid spermatids, demonstrating that RCs are s

144 closure motifs' in each complex that recruit meiotic HORMADs, the master regulators of meiotic recomb

145 est with decreased histone trimethylation at meiotic hotspots, impaired DNA double-strand-break repai

146 hus, the meiotic BRCA2 complex is central in meiotic HR, and its misregulation is implicated in cance

147 ests that majority of NAHR deletions are non-meiotic i.e. originate from errors during homology direc

148 nscription factor MEIOSIN as a gatekeeper of meiotic initiation in both male and female germ cells.

149 uncoupling of germ cell differentiation and meiotic initiation, while male PGCs exhibited repression

150 light enlargement of spermatocytes preceding meiotic initiation.

151 Here, we report that MIWI deficiency alters meiotic kinetochore assembly, significantly increases ch

152 In budding yeast, meiotic kinetochore remodeling is mediated by the tempor

153 Here, we demonstrate that LSH is enriched at meiotic kinetochores and its targeted deletion induces c

154 n and a distinct assembly pathway specialize meiotic kinetochores for successful gametogenesis.

155 , genome-scale analyses provided evidence of meiotic-like recombination between Andean and Amazonian

156 roduction and the paradox of the presence of meiotic machinery in asexual species.

157 cal coherence tomography (OCT) and automated meiotic mapping, we identified 11 mutations presumably c

158 the action of PUFA arachidonic acid (ARA) on meiotic maturation and demonstrated the control of epige

159 he reproductive hormones that trigger oocyte meiotic maturation and release from the ovary vary great

160 mimic cAMP rise at maturation onset rescued meiotic maturation and spawning.

161 molecular links between MIH stimulation and meiotic maturation initiation in hydrozoan oocytes.

162 we discovered the metabolic features during meiotic maturation, such as the fall in polyunsaturated

163 most of which is degraded during subsequent meiotic maturation.

164 the karyotype of an organism and its risk of meiotic missegregation influence the shape and evolution

165 llen of select maize lines resulted from the meiotic mobilization of specific low-copy number long-te

166 reveal novel insights into evolution of the meiotic molecular machinery in the ecologically importan

167 ty, and cyclin B1 and securin degradation in meiotic mouse oocytes.

168 s arguably the most important cause of human meiotic nondisjunction, having been linked to numerous a

169 phosphorylation by CDK-1 occurs just before meiotic onset.

170 e to birth, primarily due to aneuploidies of meiotic or mitotic origin.

171 Contrary to the prevalent meiotic origin of whole-chromosome aneuploidies, we show

172 To study diverse meiotic outcomes and how they covary across chromosomes,

173 functional sites in all mice lacking PRDM9, meiotic outcomes differ substantially.

174 e male infertility, associated with not only meiotic pachytene arrest with accompanying apoptosis, bu

175 Meiotic pairing between parental chromosomes (homologs)

176 ytes, which may at least in part mediate the meiotic phenotypes described above by affecting microtub

177 nsate, overexpression of CCNB1/2 rescues the meiotic phenotypes, indicating similar molecular propert

178 vidual and cell-to-cell variation in diverse meiotic phenotypes.

179 constrains both localization and activity of meiotic Polo-like kinases, thereby preventing premature

180 o the binding dynamics of Hop2-Mnd1 with the meiotic presynaptic complex.

181 s that return to the diploid state via a non-meiotic process of depolyploidization known as concerted

182 rapid prophase movements direct fundamental meiotic processes required for successful haploidization

183 r building the SC and the roles of the SC in meiotic processes.

184 oison-antidote mechanism to selectively kill meiotic products (spores) that do not inherit wtf4.

185 uble-stranded RNA mycoviruses and protecting meiotic progeny from the catastrophic consequences of th

186 ain enigmatic, yet essential, aspects of the meiotic program.

187 ults uncover an unexpected plasticity of the meiotic programme and show how chromosome signalling orc

188 This apparent reversal of the meiotic programme requires CHK-2 kinase reactivation via

189 DM9-dependent histone methylation and normal meiotic progress, possibly by facilitating the linking b

190 the XY body-sequesters DDR factors to permit meiotic progression from the mid-pachytene stage onward.

191 Meiotic progression involves checkpoint-controlled termi

192 to distinct subcellular localizations during meiotic progression remains poorly understood.

193 forms active kinase complexes with CDK1, and meiotic progression requires cyclin B3-associated kinase

194 Our results suggest that normal meiotic progression requires the removal of ATR-mediated

195 The absence of FIGLA significantly impedes meiotic progression, causes DNA damage and results in oo

196 embling the molecular machinery required for meiotic progression, fertilization, and embryo developme

197 play reduced and delayed MPF activity during meiotic progression, leading to defects in germinal vesi

198 rmore, we show that drive depends on slowing meiotic progression, suggesting that selfish centromeres

199 ce of the synaptonemal complex (SC) controls meiotic progression.

200 ly linking its transcriptional activation to meiotic progression.

201 alling orchestrates nuclear organisation and meiotic progression.

202 work that describes the temporal dynamics of meiotic progression.

203 intained in the ovaries in a unique state of meiotic prophase arrest.

204 e with Csm4 to drive chromosome movements in meiotic prophase by coupling telomeres to the actin cyto

205 n and localization of key protein markers of meiotic prophase events, indicating that initiation of m

206 n double-strand DNA breaks (DSBs) throughout meiotic prophase I and a concurrent reduction in male fe

207 ins and normal chromosome remodeling in late meiotic prophase I, resulting in accurate chromosome seg

208 the complete absence of CO formation during meiotic prophase I.

209 ophase events, indicating that initiation of meiotic prophase is not androgen dependent.

210 in which regulation of CO position early in meiotic prophase is required for proper designation of c

211 a molecular transcriptomic block in an early meiotic prophase state (leptotene/zygotene) in mutant ge

212 d in meiosis: Ndc80 degradation is active in meiotic prophase, but not in metaphase I.

213 During meiotic prophase, chromosomes organise into a series of

214 nding outer kinetochore sub-complexes during meiotic prophase.

215 rated A and B compartments are maintained in meiotic prophase.

216 t oocytes invariably become repressed during meiotic re-entry, whereas transcripts repressed in quies

217 direct evidence of how Rad51 is required for meiotic recombination and highlight a regulation strateg

218 his suggests individuals with lower rates of meiotic recombination are at an increased risk of produc

219 While mechanisms of DNA repair during meiotic recombination are well characterized, the same i

220 However, misplaced meiotic recombination can have catastrophic consequences

221 Meiotic recombination enables reciprocal exchange of gen

222 LSH may be essential to prevent deleterious meiotic recombination events at repetitive centromeric s

223 Meiotic recombination facilitates the transmission of ex

224 spermatogenesis with Prdm9, as an essential meiotic recombination factor required for efficient repa

225 Meiotic recombination frequency varies at multiple scale

226 oid meiosis can be enhanced by loss of a key meiotic recombination gene.

227 Our results demonstrate that MEIOB regulates meiotic recombination in a dosage-dependent manner.

228 e, we illuminate how strands exchange during meiotic recombination in male mice by analyzing patterns

229 Meiotic recombination in most mammals requires recombina

230 s recombination, a process that differs from meiotic recombination in sexual organisms.

231 ations to END-seq, we identify a SPO11-bound meiotic recombination intermediate (SPO11-RI) present at

232 Instead, it probably processes meiotic recombination intermediates by nicking double-st

233 been implicated in the biased processing of meiotic recombination intermediates into crossovers by a

234 ic distribution of MutSgamma and RFC-PCNA on meiotic recombination intermediates may drive biased DNA

235 f DNA double-strand breaks (DSBs) initiating meiotic recombination is elevated in Saccharomyces cerev

236 Meiotic recombination is initiated by SPO11-induced doub

237 Crossover localization during meiotic recombination is mediated by the fast-evolving z

238 tions occur during normal processes, such as meiotic recombination or B cell development, and others

239 Meiotic recombination proceeds via binding of RPA, RAD51

240 hisms across homologs has a strong impact on meiotic recombination rate.

241 Meiotic recombination rates vary considerably between sp

242 e segregation and offspring diversification, meiotic recombination rates vary within and between spec

243 erest to understand and utilize variation in meiotic recombination rates.

244 f S. tuberosum as a model for autotetraploid meiotic recombination research and highlight constraints

245 Meiotic recombination starts with the formation of DNA d

246 During meiotic recombination, homologue-templated repair of pro

247 the identification of a pioneer complex for meiotic recombination, this study broadens the conceptua

248 Genetic diversity in offspring is induced by meiotic recombination, which is initiated between homolo

249 urgidum ssp. durum) utilizes two pathways of meiotic recombination.

250 significance of a "pioneer complex" in mouse meiotic recombination.

251 ious alleles or stack beneficial alleles via meiotic recombination.

252 enetic dissection of mechanisms that control meiotic recombination.

253 functional and genomic features analysis of meiotic recombination.

254 wn for its role with Dmc1 recombinase during meiotic recombination.

255 es of DNA double-strand breaks that initiate meiotic recombination.

256 ods and understanding the molecular basis of meiotic recombination.

257 prophase I, consistent with MSH2 regulating meiotic recombination.

258 ols used by fruit fly geneticists to prevent meiotic recombination.

259 it meiotic HORMADs, the master regulators of meiotic recombination.

260 vealing a role for chromatin organization in meiotic recombination.

261 cific ssDNA-binding protein, regulates early meiotic recombination.

262 insight into kinetochore-derived control of meiotic recombination.

263 ole for MEIOB in crossover formation in late meiotic recombination.

264 show that mammals utilize equivalent master meiotic regulators (Stra8, Mybl1, Dazl) to regulate Ty3/

265 ns and host defense are controlled by master meiotic regulators.

266 Errors during meiotic resumption in oocytes can result in chromosome m

267 emonstrate the importance of Snf2h in oocyte meiotic resumption, but also reveal the mechanism underl

268 ked with roles in coordinating events during meiotic resumption, including polo-like kinases (PLKs).

269 From analysis of meiotic resumption, Plk1 cKO oocytes underwent nuclear e

270 To further assess the roles of PLK1 during meiotic resumption, we developed a Plk1 conditional knoc

271 le and oocytes lacking Snf2h fail to undergo meiotic resumption.

272 ing and crossing over must occur for correct meiotic segregation(1,2).

273 ion domain and Shugoshin is not required for meiotic segregation.

274 Before entry into meiosis, meiotic SEs are preprogrammed in mitotic spermatogonia t

275 Meiotic sex chromosome inactivation (MSCI) is an essenti

276 g early eukaryotic evolution - the origin of meiotic sex.

277 n the parental chromosomes is facilitated by meiotic specific adaptation of the chromosome axes and c

278 ange from the mitotic spermatogonia to early meiotic spermatocyte.

279 We show that Mtrm is enriched along the meiotic spindle and that loss of mtrm results in misloca

280 We report that PP2A is essential for meiotic spindle assembly and chromosome dynamics during

281 atanin MT-severing activity is essential for meiotic spindle assembly but is toxic for the mitotic sp

282 Interfering with early steps of meiotic spindle assembly can lead to erroneous chromosom

283 ng complex/cyclosome (APC/C) activation, and meiotic spindle assembly.

284 te closure of the NE opening surrounding the meiotic spindle in C. elegans oocytes.

285 nes directly adjacent to NE holes containing meiotic spindle microtubules.

286 Cdc23 localized on the meiotic spindle, and microinjection of Cdc23 siRNA cause

287 tomographic reconstructions of spermatocyte meiotic spindles in Caenorhabditis elegans, we find the

288 anism in the maintenance of stabilization of meiotic STAG3 cohesin complex and the modulation of hete

289 Here, we present a reference map of meiotic stages in diploid and tetraploid S. tuberosum us

290 which androgens indirectly regulate specific meiotic stages is not known.

291 portance of protein S-acylation in the early meiotic stages that lead to the development of male and

292 d Solanaceae 24-nt phasiRNAs are enriched in meiotic stages, implicating these phasiRNAs in anther an

293 6 hours and then evaluated for viability and meiotic status.

294 Germ cells clustered into six meiotic substages, as well as dying/nurse cells.

295 MS5(a) protein can move in coordination with meiotic telomeres and interact with the nuclear envelope

296 engineered Clb3 or Ama1 production restored meiotic termination in the absence of autophagy.

297 centromeres can be suppressed by regulating meiotic timing.

298 Gypsy co-opts binding sites of the essential meiotic transcription factor Ndt80 upstream of the integ

299 ing in RNA-directed DNA methylation; but the meiotic transmissibility of graft-mediated epigenetic ch

300 stence of Clb1 and Cdc5, two substrates of a meiotic ubiquitin ligase activated by Ama1.