ライフサイエンスコーパス: meiotic prophase

1 s centromeres as homologues synapse later in meiotic prophase.

2 ene-zygotene checkpoint, a key step in early meiotic prophase.

3 rated A and B compartments are maintained in meiotic prophase.

4 somes are critical for bivalent formation in meiotic prophase.

5 mes remain largely unpaired throughout first meiotic prophase.

6 ion of the nucleus that takes place in early meiotic prophase.

7 as linear elements (LinEs) are formed during meiotic prophase.

8 tly exceed 1 microm/s and persist throughout meiotic prophase.

9 shed independently of DSB formation early in meiotic prophase.

10 ete silencing of genes on the XY bivalent at meiotic prophase.

11 own to function in the chromosomal events of meiotic prophase.

12 to monitor the timing of progression through meiotic prophase.

13 Crosses homozygous for Sad-2 are blocked at meiotic prophase.

14 presumably centromeric) associations during meiotic prophase.

15 d becomes phosphorylated specifically during meiotic prophase.

16 lling the dynamic methylation of H3K9 during meiotic prophase.

17 issolving the telomere bouquet at the end of meiotic prophase.

18 te with the nuclear envelope (NE) throughout meiotic prophase.

19 osome behavior during both cell division and meiotic prophase.

20 PDS5 plays an important role at first meiotic prophase.

21 t wave of spermatogenesis progresses to late meiotic prophase.

22 g, and defective telomeric clustering during meiotic prophase.

23 connected by pairing of their centromeres in meiotic prophase.

24 duced arrest/delay at the pachytene stage of meiotic prophase.

25 display aberrant telomere clustering during meiotic prophase.

26 his distinction is made at an early stage in meiotic prophase.

27 ar complex proteins died soon after onset of meiotic prophase.

28 r alignment of homologous chromosomes during meiotic prophase.

29 e alignment of homologous chromosomes during meiotic prophase.

30 tion of centromeres and telomeres throughout meiotic prophase.

31 gonial proliferation and progression through meiotic prophase.

32 between homologous chromosomes during early meiotic prophase.

33 s, like those of most animals, arrest during meiotic prophase.

34 es cells to arrest at the pachytene stage of meiotic prophase.

35 on undergo checkpoint-mediated arrest in mid-meiotic prophase.

36 nt-mediated arrest at the pachytene stage of meiotic prophase.

37 tinuously in 16-cell cysts that have entered meiotic prophase.

38 ristic of interphase nuclei is attenuated in meiotic prophase.

39 ment of interhomologue interactions in early meiotic prophase.

40 psed autosomal bivalents in late zygonema of meiotic prophase.

41 ecomes hypermethylated in this region during meiotic prophase.

42 anscript reaching maximum abundance early in meiotic prophase.

43 sed association of telomeres with the SPB in meiotic prophase.

44 tion of Cdc2 kinase activation at the end of meiotic prophase.

45 homologues in wheat act before the onset of meiotic prophase.

46 metogenesis occurs at the pachytene stage of meiotic prophase.

47 le with arrest of gametogenesis in the first meiotic prophase.

48 2 is required for normal progression through meiotic prophase.

49 tion of a large group of genes at the end of meiotic prophase.

50 een telomeres and spindle pole bodies during meiotic prophase.

51 between paired homologous chromosomes during meiotic prophase.

52 cells exit the mitotic cell cycle and enter meiotic prophase.

53 ogous recombination events that occur during meiotic prophase.

54 protein that accumulates at telomeres during meiotic prophase.

55 tations that confer an intermediate block in meiotic prophase.

56 t period during the pachytene stage of first meiotic prophase.

57 e at which the Y chromosome condenses during meiotic prophase.

58 oximately when germ cells are known to enter meiotic prophase.

59 quence, NDC80 expression is repressed during meiotic prophase.

60 nding outer kinetochore sub-complexes during meiotic prophase.

61 increase of retrotransposition in the early meiotic prophase.

62 oscillations of the horsetail nucleus during meiotic prophase.

63 L-1 controls chromosome structure throughout meiotic prophase.

64 bias at the leptotene/zygotene transition of meiotic prophase.

65 dicating a unique role for these proteins in meiotic prophase.

66 erentiation and activates genes required for meiotic prophase.

67 essential enzyme in the progression of early meiotic prophase.

68 e eliminated by programmed cell death during meiotic prophase.

69 an elevated density of DSB markers later in meiotic prophase.

70 ubsequent reloading of CENP-A during oogenic meiotic prophase.

71 crossover recombination, which occur during meiotic prophase.

72 s in meiotic S phase, followed by entry into meiotic prophase.

73 properly localize SYCP3 and gammaH2AX during meiotic prophase.

74 lustered into one or two masses during early meiotic prophase.

75 uential expression of SPO11 isoforms in male meiotic prophase.

76 forms between homologous chromosomes during meiotic prophase.

77 etween aligned homologous chromosomes during meiotic prophase.

78 che, enter into meiosis and progress through meiotic prophase [1].

79 omes do not associate in germ cells prior to meiotic prophase [6].

80 During meiotic prophase a synaptonemal complex (SC) forms betwe

81 phosphorylation of delta is observed during meiotic prophase, a period when micronuclei become trans

82 The meiotic prophase accumulation pattern is consistent with

83 serine proteases of the subtilase family and meiotic prophase aminopeptidase 1 using mass spectrometr

84 -/- males revealed that the germ cells enter meiotic prophase and arrest at pachytene.

85 cted, beginning only in the latter stages of meiotic prophase and ending in the round spermatid stage

86 of fission yeast Schizosaccharomyces pombe (meiotic prophase and G2 phase), budding yeast Saccharomy

87 aging shows that stages X to XII, where late meiotic prophase and meiotic divisions take place, are d

88 during vegetative cell growth and with both meiotic prophase and new macronuclear development during

89 rtant for sex chromosome inactivation during meiotic prophase and nucleosome removal at postmeiotic s

90 roduction in most animals, oocytes arrest in meiotic prophase and resume meiosis (meiotic maturation)

91 duction in animals is that oocytes arrest in meiotic prophase and resume meiosis in response to extra

92 uption of spermatogenesis at the end of late meiotic prophase and subsequent meiotic divisions.

93 prevents the formation of RAD51 foci during meiotic prophase and suppresses the chromosome fragmenta

94 t SCs undergo dramatic rearrangements during meiotic prophase and that pachytene can be divided into

95 rmatogonia to stop mitosis and transition to meiotic prophase and the spermatocyte state.

96 an X-Y pairing site to nucleolar foci during meiotic prophase and to a compact structure associated w

97 The germ cells entered meiotic prophase and were arrested at pachytene stage, a

98 nterhomologous-DNA interactions occur during meiotic prophase and where breaks associated with meioti

99 hat shugoshin protects the centromeric SC in meiotic prophase and, in anaphase, promotes the proper s

100 it of germ cells from the pachytene stage of meiotic prophase and/or gamete differentiation; ablation

101 e mouse oocyte remains arrested in the first meiotic prophase, and cAMP-stimulated PKA plays an essen

102 ncomplete chromosome pairing and synapsis in meiotic prophase, and extensive chromosome fragmentation

103 ndergo the morphological changes that define meiotic prophase, and they do not display the molecular

104 d1 protein localizes to chromatin throughout meiotic prophase, and this localization requires Hop2.

105 The maintenance of meiotic prophase arrest in fully grown vertebrate oocyte

106 Maintenance of meiotic prophase arrest in fully grown vertebrate oocyte

107 The maintenance of meiotic prophase arrest in mouse oocytes within fully gr

108 In preovulatory ovarian follicles of mice, meiotic prophase arrest in the oocyte is maintained by c

109 oocyte is a common mechanism for maintaining meiotic prophase arrest in vertebrate oocytes.

110 EK1, RAD24, RAD17, and MEC1 are required for meiotic prophase arrest induced by a dmc1 mutation, whic

111 In contrast to the early meiotic prophase arrest of spermatocytes, some mutant oo

112 Failure to phosphorylate Zip1 4S results in meiotic prophase arrest, specifically in the absence of

113 h gap junctions into the oocyte, maintaining meiotic prophase arrest.

114 intained in the ovaries in a unique state of meiotic prophase arrest.

115 red chromatin (MSUC) occurs during the first meiotic prophase, as chromosomes that fail to pair are s

116 la Chk2 homolog is not required during early meiotic prophase, as has been observed for Chk2 in C. el

117 During meiotic prophase, assembly of the synaptonemal complex (

118 from this set could pair with each other in meiotic prophase at frequencies between 25 and 100%, but

119 Other mouse mutants that arrest during meiotic prophase (Atm -/-, Dmc1 -/-, mei1, and Morc(-/-)

120 A subset of the DSBs induced during meiotic prophase become designated to be repaired by a p

121 Ubb, spermatocytes and oocytes arrest during meiotic prophase, before metaphase of the first meiotic

122 Primary spermatocytes lacking PUF-8 complete meiotic prophase but do not undergo normal meiotic divis

123 m4-3, that confers a csm4Delta-like delay in meiotic prophase but promotes high spore viability.

124 approximately 300 genes coordinately during meiotic prophase, but different mRNAs within the NDT80 r

125 d in meiosis: Ndc80 degradation is active in meiotic prophase, but not in metaphase I.

126 traploid cells are exceedingly rare in early meiotic prophase, but they are the only cells that progr

127 Mammalian oocytes are arrested in meiotic prophase by an inhibitory signal from the surrou

128 f a system that regulates the progression of meiotic prophase by controlling entry of meiotic protein

129 e with Csm4 to drive chromosome movements in meiotic prophase by coupling telomeres to the actin cyto

130 ter and that Cdk1 and Ime2 trigger exit from meiotic prophase by inhibiting the Sum1 transcriptional

131 ossing over between homologs is initiated in meiotic prophase by the formation of DNA double-strand b

132 chromosome aggregates that arise during the meiotic prophase can be rescued by blocking the NHEJ pat

133 We found that germ cells already in meiotic prophase can nonetheless be sexually transformed

134 trated the association of RecA homologs with meiotic prophase chromatin.

135 Rec8 is a prominent component of the meiotic prophase chromosome axis that mediates sister ch

136 The meiotic prophase chromosome has a unique architecture.

137 tations that confer an intermediate block in meiotic prophase chromosome metabolism.

138 ion of histone H3 methylation at lysine 9 on meiotic prophase chromosomes.

139 vel with specific organizational features of meiotic-prophase chromosomes.

140 In meiotic prophase, chromosomes are organized into compact

141 During meiotic prophase, chromosomes frequently adopt a bouquet

142 During meiotic prophase, chromosomes organise into a series of

143 on and their subcellular localization during meiotic prophase coincide with that of cyclin A1, and wh

144 pattern along the lengths of chromosomes in meiotic prophase, consistent with a role as an SC protei

145 During late meiotic prophase, COSA-1 localizes to foci that correspo

146 During meiotic prophase, Ddc1 localizes to chromosomes and beco

147 osomal proteins function in the signaling of meiotic prophase defects and that the correct stoichiome

148 hal-3 (or hal-2) mutants exhibit multiple meiotic prophase defects including failure to establish

149 y organisms, homolog pairing and synapsis at meiotic prophase depend on interactions between chromoso

150 , SC fails to form, cells arrest or delay in meiotic prophase (depending on strain background), and c

151 However, except in the case of meiotic prophase, directed, rapid chromosomal movement h

152 radiation of mre-11 mutant germ cells during meiotic prophase eliminates progeny survivorship and ind

153 romosomes to become competent for subsequent meiotic prophase events and/or to coordinate replication

154 Little is known about the timing of meiotic prophase events during spermatogenesis in the mo

155 Dependencies of several meiotic prophase events on HIM-17 parallel those seen fo

156 n and localization of key protein markers of meiotic prophase events, indicating that initiation of m

157 In addition to genes involved in key meiotic prophase events, we identified genes involved in

158 heckpoint-like mechanisms couple these early meiotic prophase events.

159 at organism-specific genes with functions in meiotic prophase favor speciation by preventing fruitful

160 is blocked at two steps of DSB repair during meiotic prophase: first by the activity of the MCM-like

161 Meiotic prophase for oocyte production in hermaphrodites

162 On the other hand, meiotic prophase for sperm production in males is comple

163 tant for cohesin removal, but that cohesin's meiotic prophase functions are distinct from each other.

164 those of thousands of other genes, including meiotic prophase genes, factors mediating DNA replicatio

165 erhaps the central visible characteristic of meiotic prophase, has been a matter of intense interest

166 Cells in meiotic prophase have already replicated their DNA, but

167 During Schizosaccharomyces pombe meiotic prophase, homologous chromosomes are co-aligned

168 During meiotic prophase, homologous chromosomes engage in a com

169 1 mutant cells, like kar3 mutants, arrest in meiotic prophase; however, in cik1 mutants this arrest i

170 ss of elimination of more than two-thirds of meiotic prophase I (MPI) oocytes before birth.

171 n double-strand DNA breaks (DSBs) throughout meiotic prophase I and a concurrent reduction in male fe

172 or MRE-11 in the resection of DSBs in middle meiotic prophase I and in blocking NHEJ.

173 us macromolecular assembly that forms during meiotic prophase I and mediates adhesion of paired homol

174 C1) mediated P4-induced inhibition of oocyte meiotic prophase I and primordial follicle formation.

175 ere, we demonstrate that human oocytes enter meiotic prophase I and progress through early recombinat

176 required for normal SYN1 distribution during meiotic prophase I and suggest that ask1 associated defe

177 Oocytes are released from meiotic prophase I arrest through a process termed oocyt

178 ought to further elucidate the regulation of meiotic prophase I at the molecular cytogenetic level.

179 We propose that Mek1 plays dual roles during meiotic prophase I by phosphorylating targets directly i

180 pachytene spermatocytes are the most common meiotic prophase I cell types.

181 hat IMA-3 is required for the progression of meiotic prophase I during oocyte development.

182 control of bouquet formation and downstream meiotic prophase I events.

183 ocytes are arrested in the dictyate stage of meiotic prophase I for long periods of time, during whic

184 esis in both sexes after the major events of meiotic prophase I have been completed.

185 y akir-1 as a gene involved in key events of meiotic prophase I in Caenorhabditis elegans.

186 Meiotic prophase I is a complex process involving homolo

187 h synapsed and unsynapsed chromosomes during meiotic prophase I of spermatogenesis, with a staining p

188 signals through the RAS-ERK pathway to drive meiotic prophase I progression and oogenesis; in the abs

189 ue strongly that homolog interactions during meiotic prophase I require a novel meiosis-specific cycl

190 mologous chromosomes is a critical aspect of meiotic prophase I that aids proper disjunction at anaph

191 meiosis and then binds to chromatin in early meiotic prophase I when it regulates the leptotene-zygot

192 hesis that gap junctions maintain oocytes in meiotic prophase I when sperm are absent.

193 es, some mutant oocytes can progress through meiotic prophase I, albeit with a high frequency of nucl

194 c chromatin transitions between substages of meiotic prophase I, both at sites of genetic recombinati

195 late they completed events characteristic of meiotic prophase I, but at the first meiotic division th

196 In meiotic prophase I, homologous chromosome pairing is pro

197 e viability or gametogenesis stages prior to meiotic prophase I, mice bearing a deregulated allele (C

198 dicate that Spo11 expression begins in early meiotic Prophase I, prior to the pachytene stage, with i

199 elopmental arrest during the early stages of meiotic prophase I, providing evidence for the role of R

200 ins and normal chromosome remodeling in late meiotic prophase I, resulting in accurate chromosome seg

201 Atm-deficient mice in the earliest stages of meiotic prophase I, resulting in apoptotic degeneration.

202 AGO4 localizes to spermatocyte nuclei during meiotic prophase I, specifically at sites of asynapsis a

203 sis, recombination and bivalent formation in meiotic prophase I, subsequently resulting in seemingly

204 Interactions between homologs in meiotic prophase I, such as recombination and synapsis,

205 ssed in spermatocytes at the early stages of meiotic prophase I, the limited period when PRDM9 is exp

206 6OS1 are defective in chromosome synapsis at meiotic prophase I, which provokes an arrest at the pach

207 the complete absence of CO formation during meiotic prophase I.

208 itotic proliferation stage, pre-meiosis, and meiotic prophase I.

209 homologous DNA segments is monitored during meiotic prophase I.

210 after mitosis and the chromosome bouquet in meiotic prophase I.

211 topological distribution of telomeres during meiotic prophase I.

212 ally, while female germ cells directly enter meiotic prophase I.

213 otic cell cycle regulators might play during meiotic prophase I.

214 y be important for events occurring in early meiotic prophase I.

215 e normal patterns of H3K9 methylation during meiotic prophase I.

216 ns that also associate with chromatin during meiotic prophase I.

217 d temporally associated with synapsis during meiotic prophase I.

218 cells, and show retarded progression through meiotic prophase I.

219 rossover formation, suggesting a role during meiotic prophase I.

220 mainly located at the pericentromere during meiotic prophase II but is restricted to the inner centr

221 is required for the induction of DSBs during meiotic prophase in Drosophila females.

222 During meiotic prophase in Drosophila males, transcript for the

223 We review the critical events in early meiotic prophase in Drosophila melanogaster oocytes.

224 To study the nuclear dynamics during meiotic prophase in maize, we established a system to ob

225 chanisms affect chromosome motility in early meiotic prophase in maize.

226 and progression through the early stages of meiotic prophase in maize.

227 During meiotic prophase in male mammals, the X and Y chromosome

228 During meiotic prophase in males, the sex chromosomes partially

229 tween homologous chromosomes is initiated in meiotic prophase in most sexually reproducing organisms

230 teasome systems regulate the major events of meiotic prophase in mouse.

231 During meiotic prophase in Saccharomyces cerevisiae, expression

232 orphogenesis and nuclear organization during meiotic prophase in the Caenorhabditis elegans germline.

233 rogenitors at one end of the gonad, cells in meiotic prophase in the middle, and gametes at the other

234 polyadenylated Ott mRNA are high throughout meiotic prophase in the testis when the X chromosome is

235 ompanied by active chromosome positioning in meiotic prophase in which telomeres cluster near the spi

236 During meiotic prophase, in a conserved chromosomal configurati

237 ealed defects in the temporal progression of meiotic prophase, incomplete and aberrant synapsis of ho

238 o demonstration that oxidative stress during meiotic prophase induces chromosome segregation errors a

239 Progression through G2 as cells approach meiotic prophase is accompanied by a complete arrest of

240 The expression of Nek2 in meiotic prophase is consistent with the hypothesis that

241 m the crossover deficit, progression through meiotic prophase is largely unperturbed in msh-5 mutants

242 ophase events, indicating that initiation of meiotic prophase is not androgen dependent.

243 Meiotic prophase is predominated by short-range intrachr

244 in which regulation of CO position early in meiotic prophase is required for proper designation of c

245 Meiosis is initiated by retinoic acid and meiotic prophase is the first and most complex stage of

246 ustering on the nuclear envelope (NE) during meiotic prophase, is thought to promote homologous chrom

247 sources for the sex-specific differences in meiotic prophase kinetics are discussed.

248 The protracted arrest in meiotic prophase makes oocytes particularly susceptible

249 The events of meiotic prophase must thus occur in a strictly temporal

250 utant germ cells appear to execute events of meiotic prophase normally, and many proteins characteris

251 Sa15 forms linear structures in meiotic prophase nuclei to which Zhp3 localizes.

252 In meiotic prophase of many eukaryotic organisms, telomeres

253 During meiotic prophase of the micronucleus, when chromosomes a

254 During the entire meiotic prophase of the yeast Saccharomyces cerevisiae,

255 patial proximity of chromosomes 11 and 22 in meiotic prophase oocytes and spermatocytes plays a role

256 the forkhead transcription factor Foxl2 form meiotic prophase oocytes, but then activate the genetic

257 ranscripts in pachytene spermatocytes of the meiotic prophase, Ovol1-deficient germ cells were defect

258 ween homologous chromosomes cause a delay in meiotic prophase, perhaps to allow time for interhomolog

259 typical meiotic recombinational activity in meiotic prophase--plays an important role in the generat

260 aromyces cerevisiae can undergo meiosis, but meiotic prophase progression and subsequent nuclear divi

261 t asynapsis of heterospecific chromosomes in meiotic prophase provides a recurrently evolving trigger

262 l alignment of homologous chromosomes during meiotic prophase requires the coordination of DNA double

263 sive, genome-wide survey of histone marks in meiotic prophase, revealing a heretofore unappreciated c

264 oth mutants arrest at the pachytene stage of meiotic prophase, sae1-1 temporarily and sae3-1 permanen

265 ired by the middle of the pachytene stage of meiotic prophase, several days after homologous chromoso

266 In Atm-/- meiotic prophase spermatocytes, immuno-localization show

267 expressed in mitotic spermatogonia and early meiotic prophase spermatocytes.

268 a molecular transcriptomic block in an early meiotic prophase state (leptotene/zygotene) in mutant ge

269 zation and persistent activity of PP4 during meiotic prophase suggest a model whereby Zip1-S75 phosph

270 rsed along the nuclear envelope during early meiotic prophase, suggesting a role analogous to the tel

271 cally associating domains (TADs) are lost in meiotic prophase, suggesting that assembly of the meioti

272 somes and for normal chromosome alignment in meiotic prophase, suggesting that DCL1 has multiple func

273 In meiotic prophase, telomeres associate with the nuclear e

274 ties of the bottle-brush-like chromosomes of meiotic prophase that consist of polymer-like flexible c

275 f these observations, we propose that during meiotic prophase the presence of occasional fast moving

276 Instead of continuing through meiotic prophase, the cells attempt an abnormal mitotic-

277 induction of middle genes controls exit from meiotic prophase, the completion of the nuclear division

278 n localizes within the oocyte nucleus during meiotic prophase, the time at which exchange distributio

279 ndergoes strong checkpoint-induced arrest in meiotic prophase; the defect in cell cycle progression i

280 We show here that both meiotic prophase timing and germ-line apoptosis, one out

281 irs (bivalents) undergo restructuring during meiotic prophase to convert a configuration that promote

282 r each pair of homologous chromosomes during meiotic prophase to ensure proper segregation of chromos

283 elomeres on the nuclear envelope (NE) during meiotic prophase to form the bouquet arrangement of chro

284 we show that the successful transition from meiotic prophase to mitosis requires the modulation of C

285 genome integrity during the transition from meiotic prophase to mitosis.

286 d ability for germ cells that have completed meiotic prophase to return to the mitotic cycle, and the

287 etion allows mutants that normally arrest in meiotic prophase to sporulate at wild-type levels, thoug

288 (MSP) signals oocytes, which are arrested in meiotic prophase, to resume meiosis and ovulate.

289 mouse spermatocyte genome in early and late meiotic prophase using chromosome conformation capture (

290 ility, with failure of spermatocytes to exit meiotic prophase via the G2/MI transition.

291 A1, which are genes expressed at the end of meiotic prophase, was delayed and decreased in TR4(-/-)

292 cells, and the progression of cells through meiotic prophase were either unchanged or very slightly

293 enriched in a group of genes induced during meiotic prophase, when homologous chromosomes pair and r

294 to centromere regions of chromosomes during meiotic prophase where it remained until anaphase I.

295 MEI-P22 foci appear transiently in early meiotic prophase, which is when meiotic recombination is

296 s arrested at mid to late pachytene stage of meiotic prophase with defective synapsis of the homologo

297 n of Cdc28 helps to coordinate the events of meiotic prophase with each other and with progression th

298 op2 mutant arrests at the pachytene stage of meiotic prophase with the RecA-like protein Dmc1 located

299 The mnd1-null mutant arrests in meiotic prophase, with most double-strand breaks (DSBs)

300 Chromosomal movements take place during meiotic prophase, with telomeres congregating on the nuc