ライフサイエンスコーパス: melanin-concentrating hormone

1 antially more abundant than those containing melanin-concentrating hormone.

2 cells were distinct from those that express melanin-concentrating hormone.

3 escribed neuropeptides hypocretin/orexin and melanin-concentrating hormone.

4 wly generated neurons expressing ENK, OX, or melanin-concentrating hormone.

5 binoid-1, melanin-concentrating hormone, and melanin-concentrating hormone-1 receptor expression.

6 lateral hypothalamic neuropeptides, such as melanin-concentrating hormone(5,6).

7 related peptide, melanocortins, orexins, and melanin concentrating hormone, among other mediators.

8 e mice, C75 markedly increased expression of melanin-concentrating hormone and its receptor in the hy

9 st, direct projections to the MOB arise from melanin-concentrating hormone and orexin neurons in the

10 particular interest: pattern A, hypothalamic melanin-concentrating hormone and proopiomelanocortin bu

11 o be present, eliminated some neurons (Hcrt, melanin-concentrating hormone, and adenosine deaminase-c

12 in the brain, including neurons that secrete melanin-concentrating hormone, and culminates in the rel

13 er of hypothalamic neurons producing orexin, melanin-concentrating hormone, and histamine in 7 narcol

14 These cells included those producing orexin, melanin-concentrating hormone, and luteinizing hormone-r

15 vitro, but not in inhibiting cannabinoid-1, melanin-concentrating hormone, and melanin-concentrating

16 nsmitters found in the LHA including orexin, melanin-concentrating hormone, and nesfatin-1.

17 opiomelanocortin, thyroid-releasing hormone, melanin-concentrating hormone, and orexin expression.

18 proopiomelanocortin in the arcuate nucleus, melanin-concentrating hormone, and orexin in the lateral

19 duces excitatory synaptic strength onto both melanin-concentrating hormone- and orexin-expressing neu

20 Y (NPY), agouti-related protein (AgRP), and melanin-concentrating hormone] and anorexigenic [pro-opi

21 orexigenic peptides, enkephalin, orexin and melanin-concentrating hormone, as revealed using real-ti

22 nic neuropeptides Agouti-related peptide and melanin-concentrating hormone but surprisingly has no ef

23 with optogenetic activation of hypothalamic melanin-concentrating hormone containing cells to increa

24 citatory synaptic inputs to both orexin- and melanin-concentrating hormone expressing LHA neurons pro

25 ly implicated in this disorder: hypothalamic melanin-concentrating hormone-expressing neurons (MNs).

26 In addition, both orexin and melanin-concentrating hormone fibers made numerous close

27 Human melanin-concentrating hormone (hMCH) and many of its ana

28 Human melanin-concentrating hormone (hMCH) is a nonselective n

29 Human melanin-concentrating hormone (hMCH) is a potent but non

30 n the paraventricular nucleus and orexin and melanin-concentrating hormone in the perifornical latera

31 mygdala, OX, and another orexigenic peptide, melanin-concentrating hormone, in the perifornical later

32 xpression, increased hypothalamic Orexin and melanin-concentrating hormone, increased food intake, re

33 A, and genetic disruption of kappaOR reduced melanin concentrating hormone-induced liver steatosis.

34 In contrast, melanin-concentrating hormone levels are minimal during

35 Melanin-concentrating hormone levels increase at sleep o

36 Sections were immunostained for Hcrt-1, melanin concentrating hormone (MCH) and alpha synuclein

37 pus, lateral hypothalamic neurons containing melanin concentrating hormone (MCH) and GABA send long a

38 Melanin concentrating hormone (MCH) and the orexins (A a

39 e a selective association of these INRs with melanin concentrating hormone (MCH) and tyrosine hydroxy

40 The importance of melanin concentrating hormone (MCH) in the control of en

41 Melanin concentrating hormone (MCH) is a cyclic neuropep

42 Melanin concentrating hormone (MCH) is a hypothalamic ne

43 Melanin concentrating hormone (MCH) is an orexigenic hyp

44 Melanin concentrating hormone (MCH) is involved in regul

45 Melanin concentrating hormone (MCH) is recognised as a h

46 The neuropeptide melanin concentrating hormone (MCH) is synthesised only

47 for body weight, mice with selective loss of melanin concentrating hormone (MCH) neurons were generat

48 Hypocretin/orexin (HCRT) and melanin concentrating hormone (MCH) neuropeptides are ex

49 two hypothalamic neuropeptides oxytocin and melanin concentrating hormone (MCH) share several physio

50 ropeptide systems NPY, AGRP, orexin (OX) and melanin concentrating hormone (MCH), 3) special inductio

51 The current studies focused on melanin concentrating hormone (MCH), another orexigenic

52 s in the LH, expressing hypocretin/orexin or melanin concentrating hormone (MCH), have been shown to

53 in hypothalamus of neuropeptide Y (NPY) and melanin concentrating hormone (MCH), two neuropeptides t

54 4% of these neurons express the neuropeptide melanin concentrating hormone (MCH).

55 that produce either orexins (hypocretins) or melanin concentrating hormone (MCH).

56 the number of hypocretin (29.7% reduction), melanin concentrating hormone (MCH; 24.7% reduction), an

57 Melanin-concentrating hormone (MCH) acts via its sole re

58 in the LHA and in the posterior Pe coexpress melanin-concentrating hormone (MCH) and glutamic acid de

59 wn classes of LHA projection neurons, namely melanin-concentrating hormone (MCH) and hypocretin/orexi

60 Melanin-concentrating hormone (MCH) and hypocretin/orexi

61 Among these, melanin-concentrating hormone (MCH) and neuropeptide Y (

62 Orexigenic hormones, melanin-concentrating hormone (MCH) and orexin, were sig

63 The melanin-concentrating hormone (MCH) and orexin/hypocreti

64 ropeptide Y (NPY) in the arcuate nucleus and melanin-concentrating hormone (MCH) and orexins/hypocret

65 Two neuropeptides, melanin-concentrating hormone (MCH) and the orexins (ORX

66 mic neurons that synthesize the neuropeptide melanin-concentrating hormone (MCH) are claimed to be ac

67 Here we show that LHA neurons that produce melanin-concentrating hormone (MCH) are dynamically resp

68 orexigenic peptides hypocretin (orexin) and melanin-concentrating hormone (MCH) are involved in the

69 LHA neurons that express melanin-concentrating hormone (MCH) are key regulators o

70 Transgenic mice overexpressing melanin-concentrating hormone (MCH) are obese and a seco

71 Hypothalamic neurons that utilize melanin-concentrating hormone (MCH) as a neuromodulator

72 the use of Eu3+ chelate-labeled analogues of melanin-concentrating hormone (MCH) as ligands for both

73 Melanin-concentrating hormone (MCH) has been known to be

74 Orexin and melanin-concentrating hormone (MCH) have been implicated

75 Ablation of neurons that express melanin-concentrating hormone (MCH) in adult Lep(ob/ob)

76 Melanin-concentrating hormone (MCH) is a 19-aa cyclic ne

77 Melanin-concentrating hormone (MCH) is a 19-amino-acid c

78 Melanin-concentrating hormone (MCH) is a conserved neuro

79 Melanin-concentrating hormone (MCH) is a cyclic 19-aa hy

80 Melanin-concentrating hormone (MCH) is a cyclic, nonadec

81 Melanin-concentrating hormone (MCH) is a hypothalamic ne

82 Melanin-concentrating hormone (MCH) is a hypothalamic ne

83 Melanin-concentrating hormone (MCH) is a hypothalamic pe

84 Melanin-concentrating hormone (MCH) is a neuropeptide hi

85 Melanin-concentrating hormone (MCH) is a small cyclic pe

86 s of evidence indicate that the neuropeptide melanin-concentrating hormone (MCH) is an important comp

87 Melanin-concentrating hormone (MCH) is an important regu

88 Melanin-concentrating hormone (MCH) is an orexigenic neu

89 Melanin-concentrating hormone (MCH) is expressed primari

90 Melanin-concentrating hormone (MCH) is implicated in the

91 Melanin-concentrating hormone (MCH) is involved in the r

92 Melanin-concentrating hormone (MCH) is produced mainly i

93 Neurons that synthesize melanin-concentrating hormone (MCH) may modulate arousal

94 orrelated with both neuropeptide Y (NPY) and melanin-concentrating hormone (MCH) mRNA.

95 spontaneous behavioral acts and activity of melanin-concentrating hormone (MCH) neurons (MNs) in beh

96 and VGAT neurons [4-7] and orexin- (ORX) and melanin-concentrating hormone (MCH) neurons [8-10].

97 Melanin-concentrating hormone (MCH) neurons and MCH-1 re

98 lateral hypothalamic (LH) circuits involving melanin-concentrating hormone (MCH) neurons are subject

99 tudy, we show that optogenetic activation of melanin-concentrating hormone (MCH) neurons during intak

100 During encounters with objects, hypothalamic melanin-concentrating hormone (MCH) neurons emit brief s

101 Melanin-concentrating hormone (MCH) neurons have been im

102 esity (DIO) by activating appetite-promoting melanin-concentrating hormone (MCH) neurons in the hypot

103 Melanin-concentrating hormone (MCH) neurons in the later

104 Here, we focus on the melanin-concentrating hormone (MCH) neurons in the later

105 Melanin-concentrating hormone (MCH) neurons play an impo

106 creased the activity of lateral hypothalamic melanin-concentrating hormone (MCH) neurons selectively

107 in-releasing peptide (PrRP) cells innervated melanin-concentrating hormone (MCH) neurons that are cru

108 (mGluR1 and mGluR5) activation on identified melanin-concentrating hormone (MCH) neurons was studied

109 Melanin-concentrating hormone (MCH) neurons, which are i

110 ned mice to map the activity of hypothalamic melanin-concentrating hormone (MCH) neurons.

111 they are distinct from hypocretin/orexin and melanin-concentrating hormone (MCH) neurons.

112 s expression in orexinergic but not adjacent melanin-concentrating hormone (MCH) neurons; suggesting

113 amic neurons including those that synthesize melanin-concentrating hormone (MCH) or hypocretin/orexin

114 A molecular model of the human melanin-concentrating hormone (MCH) peptide was construc

115 Melanin-concentrating hormone (MCH) plays an essential r

116 Hypothalamic melanin-concentrating hormone (MCH) polypeptide contribu

117 s that both PrRP and PrRP-NA cells innervate melanin-concentrating hormone (MCH) producing neurons in

118 We demonstrate that melanin-concentrating hormone (MCH) receptor 1, a GPCR t

119 n suggest that the hypothalamic neuropeptide melanin-concentrating hormone (MCH) regulates body weigh

120 Melanin-concentrating hormone (MCH) regulates feeding an

121 Melanin-concentrating hormone (MCH) regulates vital phys

122 The melanin-concentrating hormone (MCH) system is thought to

123 t fertility also upregulate the hypothalamic melanin-concentrating hormone (MCH) system that promotes

124 Melanin-concentrating hormone (MCH) was initially identi

125 The percentage of melanin-concentrating hormone (MCH)+/Fos+ neurons in the

126 Melanin-concentrating hormone (MCH), a conserved cyclic

127 Melanin-concentrating hormone (MCH), a cyclic 19-amino-a

128 e AcbSh contains high levels of receptor for melanin-concentrating hormone (MCH), a lateral hypothala

129 Melanin-concentrating hormone (MCH), a neuropeptide expr

130 ntibodies against tyrosine hydroxylase (TH), melanin-concentrating hormone (MCH), and hypocretin (Hcr

131 ontaining the feeding-related neuropeptides, melanin-concentrating hormone (MCH), and orexin (Orx).

132 ressin (AVP), histidine decarboxylase (HDC), melanin-concentrating hormone (MCH), and orexin/hypocret

133 rected to rWAT and iWAT expressed orexin and melanin-concentrating hormone (MCH), but male rats had a

134 eurons, and not nearby LH neurons expressing melanin-concentrating hormone (MCH), have mu-opioid rece

135 Ablation of the hypothalamic peptide, melanin-concentrating hormone (MCH), leads to a lean phe

136 LHAad did not express significant amounts of melanin-concentrating hormone (MCH), orexin, or galanin;

137 oopiomelanocortin (POMC), orexin/hypocretin, melanin-concentrating hormone (MCH), thyrotropin-releasi

138 Pmch encodes melanin-concentrating hormone (MCH), which is produced i

139 e distinct from neighboring leptin-regulated melanin-concentrating hormone (MCH)- or orexin (OX)-expr

140 Melanin-concentrating hormone (MCH)-deficient mice are h

141 ing impulsivity involving communication from melanin-concentrating hormone (MCH)-expressing lateral h

142 Melanin-concentrating hormone (MCH)-expressing neurons h

143 Melanin-concentrating hormone (MCH)-producing neurons ar

144 detectable effect on neurons that synthesize melanin-concentrating hormone (MCH).

145 s, hypocretin (HCRT; also called orexin) and melanin-concentrating hormone (MCH).

146 elanocyte-stimulating hormone (alphaMSH) and melanin-concentrating hormone (MCH).

147 e VTA contain the hypothalamic neuropeptide, melanin-concentrating hormone (MCH).

148 ligand of this receptor is the neuropeptide melanin-concentrating hormone (MCH).

149 lamus of ob/ob mice encodes the neuropeptide melanin-concentrating hormone (MCH).

150 behaviour through the actions of orexin and melanin-concentrating hormone (MCH).

151 ortin (POMC), agouti-related peptide (AgRP), melanin-concentrating-hormone (MCH) and orexin (ORX) neu

152 LH melanin-concentrating-hormone (MCH) and orexin/hypocreti

153 kefulness (orexin/hypocretin; OH), or sleep (melanin-concentrating hormone; MCH).

154 A novel series of melanin-concentrating hormone (MCH1) receptor antagonist

155 hypothalamic neuropeptides, hypocretin-1 and melanin-concentrating hormone, measured in the human amy

156 greatly increases Agouti-related peptide and melanin-concentrating hormone mRNA expression.

157 ght to moderate inputs arose from orexin and melanin concentrating hormone neurons, but cholinergic o

158 nd a lack of effect on leptin sensitivity of melanin concentrating hormone neurons.

159 Glut4 neuron ablation affects orexigenic melanin-concentrating hormone neurons but has limited ef

160 in gene transfer into the striatum or in the melanin-concentrating hormone neurons in the ZI or LH ha

161 excitatory current with repeated coexposure (melanin-concentrating hormone neurons), synergistic dire

162 Neither rPP nor NPY stimulated c-Fos in melanin-concentrating hormone neurons, but both activate

163 erifornical hypothalamic area, few contained melanin-concentrating hormone or orexin.

164 rons and/or fibers in this area positive for melanin concentrating hormone, oxytocin, arginine vasopr

165 ons and contain dopamine, histamine, orexin, melanin-concentrating hormone, oxytocin, and vasopressin

166 , agouti-related peptide, hypocretin/orexin, melanin-concentrating hormone, oxytocin, arginine vasopr

167 Expression of transcripts for human pro-melanin concentrating hormone (pMCH) were studied in the

168 ve (Orx(+)), whereas none were identified as melanin-concentrating hormone-positive.

169 We found that melanin concentrating hormone-producing neurons (MCH neu

170 kappaOR colocalizes with melanin concentrating hormone receptor 1 (MCH-R1) in the

171 otypes of mice with targeted deletion of the melanin concentrating hormone receptor 1 (MCH1-R).

172 -2-o ne (7) is a potent, orally bioavailable melanin concentrating hormone receptor 1 (MCHr1) antagon

173 A novel series of melanin concentrating hormone receptor 1 (MCHr1) antagon

174 mitogen-activated protein kinase 7 (MAPK7), melanin concentrating hormone receptor 1 (MCHR1), and sp

175 of multiple structurally distinct series of melanin concentrating hormone receptor 1 antagonists in

176 ormation but disrupts normal localization of melanin concentrating hormone receptor 1 to ciliary memb

177 ioselective synthesis of SNAP-7941, a potent melanin concentrating hormone receptor antagonist, was a

178 Melanin-concentrating hormone receptor 1 (MCH-R1) is a G

179 We identified the consensus sequence in melanin-concentrating hormone receptor 1 (Mchr1) and con

180 screening mode to triage multiple classes of melanin-concentrating hormone receptor 1 (MCHr1) antagon

181 DNA phage-display library, we identified the melanin-concentrating hormone receptor 1 (MCHR1) as a no

182 of somatostatin receptor type 3 (Sstr3) and melanin-concentrating hormone receptor 1 (Mchr1) in neur

183 The melanin-concentrating hormone receptor 1 (MCHR1) is a G

184 n of a high-throughput screening hit against melanin-concentrating hormone receptor 1 (MCHr1) led to

185 Deletion derivatives of melanin-concentrating hormone receptor 1 complementary D

186 The [35S]-labeled melanin-concentrating hormone receptor 1 derivatives wer

187 ts exhibited autoantibodies to more than one melanin-concentrating hormone receptor 1 epitope indicat

188 identification of autoantibodies against the melanin-concentrating hormone receptor 1 in patients wit

189 ediction of the potential B cell epitopes on melanin-concentrating hormone receptor 1 revealed that t

190 In this study, the B cell epitopes on melanin-concentrating hormone receptor 1 that are recogn

191 stence of multiple antibody binding sites on melanin-concentrating hormone receptor 1, including regi

192 Melanin-concentrating hormone receptor antagonists conta

193 ) and found that the distribution of ciliary melanin-concentrating hormone receptor-1 (MchR1) was sig

194 s for the G-protein-coupled receptor (GPCR), melanin-concentrating hormone receptor-1 (MCHR1), with a

195 are potent but nonspecific ligands for human melanin-concentrating hormone receptors 1 and 2 (hMCH-1R

196 s a potent but nonselective agonist at human melanin-concentrating hormone receptors 1 and 2 (hMCH-1R

197 e neighbors include opioid, somatostatin and melanin-concentrating hormone receptors.

198 a nonselective natural ligand for the human melanin-concentrating hormone receptors: hMCH-1R and hMC

199 by alpha-melanocyte-stimulating hormone and melanin-concentrating hormone, respectively.

200 Further, we find that melanin-concentrating hormone signalling (which is invol

201 altered mRNA expression levels of orexin and melanin-concentrating hormone, two peptides that are imp

202 Hypocretin, melanin concentrating hormone, tyrosine hydroxylase, neu