ライフサイエンスコーパス: melanocytic nevi

1 he distinction of melanoma from conventional melanocytic nevi.

2 dded tissue sections in primary melanoma and melanocytic nevi.

3 l-dominant immunity in clinically regressing melanocytic nevi.

4 melanomas are derived directly from benign, melanocytic nevi.

5 alyzed the difference between DNs and common melanocytic nevi.

6 2% of primary melanomas were associated with melanocytic nevi.

7 valence and morphologic features of perianal melanocytic nevi.

8 nomas (primary and metastatic) compared with melanocytic nevi.

9 melanomas compared with primary melanoma and melanocytic nevi.

10 n reported in individual cases of congenital melanocytic nevi.

11 nonsquamous (1 pingueculum, 1 dermolipoma, 2 melanocytic nevi, 1 melanoma).

12 from 100 biopsy-proven lesions, including 55 melanocytic nevi, 20 melanomas, 15 basal cell carcinomas

13 Among children with multiple congenital melanocytic nevi, 25% have no established genetic cause,

14 Melanocytic nevi also demonstrated catK expression, but

15 is is involved in persistence of NRAS-driven melanocytic nevi and anticipate that targeted small inte

16 ations of NRAS and BRAF were found in benign melanocytic nevi and cutaneous melanomas.

17 to better understand the characteristics of melanocytic nevi and define pathways of melanocytic tumo

18 These results show that although melanocytic nevi and dysplastic nevi harbor stable genom

19 haracterized by the sudden onset of numerous melanocytic nevi and have been traditionally described i

20 owed abundant expression of MAP-2 protein in melanocytic nevi and in the in situ and invasive compone

21 Increased expression of miR211-5p stabilizes melanocytic nevi and keeps them in a growth-arrested sta

22 In this study, melanocytic nevi and malignant melanomas were examined b

23 ptosis inhibitor Survivin to be expressed in melanocytic nevi and melanoma but not in normal melanocy

24 K pathway genes are commonly associated with melanocytic nevi and melanoma, whereas germline variants

25 ns of chromosomal aberrations between benign melanocytic nevi and melanoma.

26 ce in growth arrest and tumor suppression in melanocytic nevi and melanoma.

27 l impression and current knowledge, acquired melanocytic nevi and melanomas may not occur in random l

28 BRAF mutations occur at a high frequency in melanocytic nevi and metastatic lesions, but recent data

29 d malignant melanocytic neoplasms, including melanocytic nevi and primary invasive and metastatic mel

30 ful delivery into a humanized mouse model of melanocytic nevi and results in variant NRAS knockdown i

31 aberration in melanoma that is distinct from melanocytic nevi and should be further evaluated as a di

32 squamous cell carcinoma, actinic keratosis, melanocytic nevi, angiokeratoma, dermatofibroma, solar l

33 molecular differences between DNs and common melanocytic nevi are not completely understood.

34 Giant congenital melanocytic nevi are NRAS-driven proliferations that may

35 Melanocytic nevi are the most potent risk factors for me

36 icroscope to image in vivo and noninvasively melanocytic nevi at three different stages: common nevi

37 arcinomas, actinic keratoses, atypical nevi, melanocytic nevi, blue nevi, and seborrheic keratoses.

38 confirmatory, showing a strong signal in the melanocytic nevi but progressive signal attenuation with

39 loss abrogates growth arrest of Braf(V600E) melanocytic nevi, but is insufficient for complete progr

40 and -mRNA was characterized in melanomas and melanocytic nevi by immunocytochemistry and in situ reve

41 discriminative genes between DNs and common melanocytic nevi by three independent statistical approa

42 typical moles, are distinguished from common melanocytic nevi by variegation in pigmentation and clin

43 Melanoma and benign melanocytic nevi can overlap significantly in their hist

44 Congenital melanocytic nevi (CMN) and infantile hemangiomas are com

45 Large congenital melanocytic nevi (CMN) are at an increased risk of devel

46 Congenital melanocytic nevi (CMN) are pigmented birthmarks that aff

47 Congenital melanocytic nevi (CMN) can be associated with neurologic

48 les (PNs) and melanoma arising in congenital melanocytic nevi (CMN) is crucial, as patients with PNs

49 15 Expression was significantly increased in melanocytic nevi compared with melanomas (mean H scores,

50 A high melanocytic nevi count is the strongest known risk facto

51 Most melanocytic nevi develop on sun-exposed skin during chil

52 d molecular bases of acquired and congenital melanocytic nevi during childhood.

53 prone to developing large, markedly atypical melanocytic nevi (EB nevi), which may mimic melanoma cli

54 Eruptive melanocytic nevi (EMN) are characterized by the sudden o

55 Benign melanocytic nevi frequently emerge when an acquired BRAF

56 Melanocytic nevi frequently harbor oncogenic BRAF mutati

57 alogous genotypic profiles for epidermal and melanocytic nevi from recent studies.

58 Acquired melanocytic nevi grow and persist in a stable form into

59 Melanoma and melanocytic nevi harbor shared lineage-specific antigens

60 While melanocytic nevi have been associated with genetic facto

61 in the primary melanomas than in the benign melanocytic nevi, however, only p53 over-expression was

62 opathologic examination revealed remnants of melanocytic nevi in 103 melanomas (54.2%).

63 pproach to small- or medium-sized congenital melanocytic nevi in black children must be different bec

64 Numbers and distribution of melanocytic nevi in childhood are major indicators of th

65 the natural history and clinical spectrum of melanocytic nevi in children as well as potentially worr

66 atypical mole phenotype, development of new melanocytic nevi in older individuals is uncommon and co

67 ed to prevalence and morphologic features of melanocytic nevi in the perianal area.

68 We studied 169 patients with congenital melanocytic nevi in this study, 38 of whom were double w

69 adigm for understanding the growth arrest of melanocytic nevi in vivo termed stable clonal expansion.

70 tential of the method to distinguish between melanocytic nevi in vivo.

71 nevi) from melanoma, we sequenced exomes of melanocytic nevi including dysplastic nevi (n = 19), fol

72 Additionally, melanocytic nevi including dysplastic nevi showed a sign

73 to determine the discriminatory profiles of melanocytic nevi (including dysplastic nevi) from melano

74 t approximately 50% of the existing acquired melanocytic nevi involuted, while the remaining nevi did

75 Importance: The presence of numerous melanocytic nevi is a significant melanoma risk factor,

76 A large number of melanocytic nevi is the strongest known risk factor for

77 e relationship between the immune system and melanocytic nevi is unclear.

78 cal management of large and giant congenital melanocytic nevi (lgCMN) relies heavily upon iterative s

79 expression of PEDF in common and dysplastic melanocytic nevi, melanoma in situ, invasive melanoma, a

80 Human melanocytic nevi (moles) result from a brief period of c

81 A survey of benign melanocytic nevi (moles), suspected precursors or marker

82 d gene panel (785 genes) characterization of melanocytic nevi (n = 46) and primary melanomas (n = 42)

83 diatricians to discuss treatment options for melanocytic nevi, nevus sebaceus, port-wine stains, and

84 epts of the risks associated with congenital melanocytic nevi of different sizes and strategies for t

85 utaneous melanoma but infrequently in benign melanocytic nevi or other melanocytic lesions, suggestin

86 es were preferentially represented in benign melanocytic nevi over melanomas and selectively mapped t

87 We report genome duplication in human melanocytic nevi, reciprocal expression of AURKB and mic

88 which growth arrest can be overcome and how melanocytic nevi relate to melanoma are also considered.

89 compared with those from young, and in human melanocytic nevi relative to normal skin.

90 nome-wide association study on the number of melanocytic nevi reported by 9136 individuals of Europea

91 The density of acquired melanocytic nevi represents an important risk factor for

92 F1, RAC1, and PTEN, were not found among any melanocytic nevi sequenced.

93 melanoma is the presence of large numbers of melanocytic nevi so that genes controlling nevus phenoty

94 y role for Wnt signaling in the formation of melanocytic nevi, suggesting that activated Wnt signalin

95 This review summarizes the types of melanocytic nevi that are commonly observed in children,

96 the first to characterize certain pigmented melanocytic nevi that may also fit this paradigm.

97 Spitz nevi are benign melanocytic nevi that overlap histopathologically with m

98 pe characterized by the presence of multiple melanocytic nevi: the atypical mole syndrome.

99 ith dermoscopy are associated with enlarging melanocytic nevi, their actual growth dynamics remain un

100 differentiating dysplastic nevi from common melanocytic nevi through a molecular lens.

101 lesions predisposing to malignancy, such as melanocytic nevi, thyroid nodules, and colonic polyps.

102 in clinical melanoma tissues, compared with melanocytic nevi tissues.

103 stages of malignant progression from common melanocytic nevi to metastatic melanomas and examine the

104 udinal tracking of microscopic structures in melanocytic nevi using RCM is feasible.

105 undruggable NRAS(Q61K) in primary cells from melanocytic nevi using small interfering RNA targeted to

106 ions between primary cutaneous melanomas and melanocytic nevi vary widely between 4% and 72%.

107 f BRAF oncogenic mutations was identified in melanocytic nevi, VGP, metastatic melanomas, and melanom

108 Phenotypical data on melanocytic nevi were collected from a random sample of

109 sions and Relevance: In this study, perianal melanocytic nevi were common and were associated with pr

110 Despite this, the vast majority of melanocytic nevi, which typically form as a result of BR

111 ry oncogenes, which typically lead to benign melanocytic nevi with characteristic histologic features

112 MN) syndrome is the association of pigmented melanocytic nevi with extra-cutaneous features, classica