ライフサイエンスコーパス: membered

1 ns,trans-diastereoselective assembly of five-membered (1-halovinyl)lactones has been developed.

2 ti-IgE Affibody (ZIgE), generating a 160,000-membered, 4-site, saturation library on the surface of 8

3 tyl) 2 and 3, featuring an unsaturated three-membered AlCP ring, have been synthesized as crystalline

4 ns suggest the reversible formation of a six-membered alkenyl palladacycle intermediate through a tur

5 e as a covalent scaffold in the axis of a 30-membered all-carbon macrocycle provides access to a modu

6 lving the pseudoaxial substituent in the six-membered allylation transition state.

7 For instance, cyclic five-membered alpha-oxoketenes lead preferentially to spiro h

8 ng to indolines, dihydrobenzofurans, and six-membered analogues.

9 ed of dimethylcyclodecatriene flanked by a 7-membered and a 6-membered lactone ring based on spectros

10 ort the computations, showing that the seven-membered and acyclic hydrazide catalysts react 10 times

11 hetic approach was carried out to form seven-membered and eight-membered rings, giving rise to tetran

12 his methodology was further extended to five-membered and six-membered cyclic secondary alcohols.

13 Using a 256-membered ANNNN comonomer library comprising 16 sublibrar

14 Five-membered aromatic heterocycles are a ubiquitous skeleton

15 The chemoselective cleavage of a six-membered aromatic ring in biphenylene is reported using

16 mbered aromatic rings of FeCp(2) and the six-membered aromatic ring of C(6)F(6).

17 arkably strong interactions between the five-membered aromatic rings of FeCp(2) and the six-membered

18 he organocatalytic ROP of these specific six-membered asymmetric cyclic glucose carbonates.

19 philic functional group allowed obtaining 10-membered azaenediyne, while the substrate with a hydroxy

20 erocyclization and into the synthesis of six-membered azaheterocycles.

21 imited by protonolysis of the intermediate 5-membered azametallacycle.

22 A series of 4-membered azametallacycles have been prepared by the oxid

23 at provides a straightforward route to seven-membered azepino[3,2,1-hi]indoles in good to excellent y

24 cently discovered that incorporation of four-membered azetidine rings into classic fluorophore struct

25 es that hydrolyze the amide bond of the four-membered beta-lactam ring are the primary resistance mec

26 as been developed for the synthesis of seven-membered biaryl lactams involving Pd-catalyzed, native a

27 , as is the potential for synthesizing eight-membered biaryl lactams.

28 incorporation of the [B-C] motif into a five-membered boramidine, which exists as a mixture of Z and

29 athesis served for construction of the seven-membered C ring.

30 lision sites are near the centers of the six-membered C-rings.

31 ) P(3) H)(2) Rb(4) ] (5) featuring four five-membered [C(2) P(3) ] phosphorus heterocycles, which can

32 n of a wide range of highly functionalized 6-membered carbo- and heterocyclic molecules in a single s

33 r undergo [1,3] N-to-C rearrangement to five-membered carbocycles with a different palladium catalyst

34 s rapid access to highly functionalized five-membered carbocycles, bearing an all-carbon quaternary s

35 e cycloaddition is more favored to give four-membered carbocyclic adducts, thereby precluding the req

36 ng electron-poor sigma bonds, with the seven-membered catalyst achieving a nearly ideal transition-st

37 catalysts react 10 times faster than the six-membered catalyst.

38 hesis of a new cyclic azobenzene with a nine-membered central ring and distinct properties.

39 c evidence supporting the formation of a six-membered chelate through coordination of the proximal po

40 s with hydroxyl groups forming five- and six-membered chelation complexes with the iodine atom.

41 By the nature of its structure, the 5-membered chiral biaryl heterocyclic scaffold represents

42 eteroaryl groups, producing functionalized 5-membered chiral cyclic sulfonamides in high yields with

43 We report here hitherto unavailable eight-membered chlorin-type PMPs using an inverted "mending an

44 Formation of a 7-membered cobaltacycle by C-H activation and migratory in

45 mination and hydride reinsertion to give a 6-membered cobaltacycle that then reacts with the cyanatin

46 LUMO energy and enabling a less-strained six-membered coordination mode.

47 eductive cyclization of a 1,8-enyne, a seven-membered cycle was isolated as a unique product with a t

48 ith indole, instead of the formation of a 10-membered cycle, BF(3)-promoted addition of an OH-group t

49 five-membered tetramic acid analogues to six-membered cycles.

50 action with alpha-substituted five- to seven-membered cyclic amines proceeds very efficiently to prov

51 Six-membered cyclic carbamates are prepared in good yield wi

52 A dual seven-membered cyclic carbonate/olefin monomer was synthesized

53 ed ring-opening polymerizations (ROP) of six-membered cyclic d-glucose-based carbonates was found to

54 any of its members possessing a brominated 8-membered cyclic ether among other distinct structural el

55 ers of the class encompassing two distinct 8-membered cyclic ether ring collections.

56 ring expansion strategy for preparing seven-membered cyclic ketones.

57 ion and bromination of readily available six-membered cyclic nitronates (1,2-oxazine-N-oxides) are re

58 a residue 6 tryptophan, thereby forming a 20-membered cyclic peptide.

59 Our six-membered cyclic phosphoester ring-opening polymerization

60 as further extended to five-membered and six-membered cyclic secondary alcohols.

61 ylation has been evaluated for 4-, 5-, and 6-membered cyclic secondary amines, including medicinally

62 ree, and eco-friendly domino reaction of 5/6-membered cyclic sulfamidate imines with a variety of bet

63 ducing both enantiomers of the strained five-membered cyclic sulfamides with excellent enantioselecti

64 H amination to stereoselectively construct 5-membered cyclic sulfonamides.

65 ellent chemo- and regioselectivities to five-membered cyclic ureas have been achieved under ambient c

66 We report that an agile eight-membered cycloalkane can be stabilized by fusing a benze

67 Ring-closing alkyne metathesis allowed a 13-membered cycloalkyne to be forged, which was selectively

68 ed hydrocarbons containing antiaromatic four-membered cyclobutadienoids (CDB) are of great fundamenta

69 etition experiment between the five- and six-membered cyclopalladation step, as well as kinetic exper

70 ructures of the major compounds, two 14-ring-membered cyclopeptide alkaloids, which were named opunti

71 recting group (DG) enabling formation of six-membered cycloruthenated species responsible for the con

72 derived five-membered gamma-lactones and six-membered delta-lactones that occur with terpenoid scaffo

73 ms) side chains, and thus, larger (11- to 12-membered) diarene-fused rings were obtained via the homo

74 [2 + 2] cycloaddition, which leads to a four-membered diazacyclobutene intermediate with a barrier co

75 of eta(4)-bound methyl arenes to give eight-membered diiridium metallacycles with yields up to 99%.

76 s that directly polymerize mixtures of eight-membered diolide (8DL) monomers with varying starting ra

77 ized reactions, we constructed a 9.8-million-membered DNA-encoded chemical library.

78 The wrapped arrangement of the six-membered dqp chelating ligands around the Cr(III) provid

79 one or two naphthalimide units fused to five-membered electron-rich heterocyles were systematically i

80 ater mixture and the investigation of the 10-membered enediynes' reactivity in the Bergman cyclizatio

81 ontaining phosphatase 2 (SHP2) and the three-membered family of phosphatases of regenerating liver (P

82 Polo-like kinases (PLKs), a five membered family of Ser/Thr protein kinases, have long be

83 (alkyl)(amino)aluminyl anion based on a five-membered framework.

84 pective article, selected plant-derived five-membered gamma-lactones and six-membered delta-lactones

85 rary formation of a gamma-turn and a rare 11-membered H-bonded structure in the 2->4 opposite directi

86 is presented to trap an elusive cyclic, four-membered hemiaminal structure.

87 the regioselectivities of reactions of five-membered heteroarenes that occur with selectivities dict

88 ed cascade route allows the placement of six-membered heteroaromatic rings at the sterically crowded

89 ent of psoriasis, began with a survey of six-membered heteroaryl groups in place of the N-methyl tria

90 hieve this through the inclusion of a [4n] 5-membered heterocycle, whose electronic resonance promote

91 [B(C(6)F(5))(4)] to give the respective five-membered heterocycle.

92 able C5-carbon chain, five-, six-, and seven-membered heterocycles, and natural product diversificati

93 class of important cis-1,4-disubstituted six-membered heterocycles, including dihydropyran and tetrah

94 conditions has been developed to afford six-membered heterocycles.

95 o the synthesis of PMPs containing up to six-membered heterocycles; the syntheses of larger rings fai

96 erials has been developed for building seven-membered heterocyclic architectures.

97 r the synthesis of beta-benzyl-substituted 5-membered heterocyclic carbaldehydes via transient direct

98 egy for the preparation of 3-, 4-, 5-, and 6-membered heterocyclic unnatural amino acid derivatives b

99 nantiodiscrimination was observed for the 20-membered host 10, containing six HB acceptors ( K(R)/ K(

100 ial supramolecular polymer systems using six-membered hydrogen-bonded supramolecular complexes (roset

101 ment of CNMe ether in the formation of a six-membered imine-type cyclic intermediate for the observed

102 3 + 2] cycloaddition strategy to append five membered isoxazole and isoxazolone as new phytochemical

103 nstruction of five-, six-, seven-, and eight-membered lactams with stereochemical preference conferre

104 s, which are sulfenamides derived from seven-membered lactams.

105 Among them, a monooxygenated, seven-membered lactone intermediate as a monodentate ligand of

106 lodecatriene flanked by a 7-membered and a 6-membered lactone ring based on spectroscopic analysis.

107 odiene contained within a highly strained 16-membered lactone ring, which also incorporates two trans

108 of free carboxylic acids to form diverse six-membered lactones.

109 D acts with a partner protein to form the 12-membered macroamidine unique to bottromycins.

110 limited due to challenges associated with 12-membered macrocycle and modified pyridine synthesis.

111 The 18-membered macrocycle H2 macropa was investigated for (225

112 al bioavailability in the imidazole-based 13-membered macrocycle to the 12-membered macrocycle.

113 azole-based 13-membered macrocycle to the 12-membered macrocycle.

114 Thus, within [4]- and [6]-membered macrocycles, poly-zwitterionic structures can b

115 e conversion of precursor molecules into six-membered macrocycles, which constitute the fibers.

116 ural polyketide products harboring 14- to 16-membered macrocyclic lactone rings to which various suga

117 The 16-membered macrocyclic lactone was formed via ring closing

118 Herein, we report two 18-membered macrocyclic ligands called macrodipa and macrot

119 ctively modifying the chemically complex, 23-membered macrocyclic scaffold of group A streptogramins,

120 quisite trisubstituted (8E)-alkene in the 12-membered macrolactone, followed by the controlled instal

121 Synthesis of the 14-membered macrolide core of migrastatin is accomplished b

122 The 20-membered marine macrodiolide clavosolide A is prepared i

123 ntadienyl, (t)Bu = tert-butyl), a strained 4-membered metallacycle bearing a free carbene, is describ

124 studies suggest that formation of the seven-membered metallacycle becomes possible when an alpha-sub

125 through Cu-mediated C7-H activation via a 6-membered metallacycle to afford the amide and amine deri

126 The reaction possibly proceeds through five-membered metallacycle under redox-neutral condition.

127 rmation compared to isomerization to a seven-membered metallacycle, the most likely mechanism has bee

128 Analogous reactions that occur through four-membered metallacycles are rare.

129 a directing group that leads to five- or six-membered metallacyclic intermediates.

130 ]C, C[double bond, length as m-dash]C), five-membered metallacycloallenes Cp'2M[eta2-C(R)[double bond

131 [triple bond, length as m-dash]C), and seven-membered metallacyclocumulenes Cp'2M[eta2-C(R)[double bo

132 that these complexes have nearly planar, 11-membered metallatricycles with metrical parameters that

133 ferent isonitriles afforded a series of five-membered N(2)P(2)C heterocycles.

134 A seven-membered N,N'-heterocyclic potassium alumanyl nucleophil

135 red by C-C bond activation to generate eight-membered N-heterocycles.

136 the successful syntheses of 12-, 13-, and 14-membered natural product CTPs and their novel analogues

137 -cembranoid sinulariadiolide (1) with a nine-membered nexus was obtained by a cascade of transannular

138 O(2)S(Ph-NMe2) unit pointing out of the five-membered Ni-O-S-Fe-S' ring.

139 routes for novel thieno-fused five- and six-membered nitrogen and oxygen heterocycles such as thieno

140 luoroethylated and N-difluoromethylated five-membered nitrogen heterocycles was demonstrated with azi

141 , a series of GABA analogues comprising five-membered nitrogen- and sulfur-containing heterocycles as

142 Azetidines are four-membered nitrogen-containing heterocycles that hold grea

143 To construct multisubstituted seven-membered nitrogenous heterocyclic scaffolds, an efficien

144 Nicholas reaction for the preparation of 10-membered O- and N-enediynes fused to indole, 1,2,3-triaz

145 Additionally, the formation of 8-membered organo(fluoro)phosphate rings in lithium ion ba

146 xyl group gave only traces of the desired 10-membered oxacycle.

147 omoted cyclic dialkyl ether formation from 6-membered oxanickelacycles originally reported by Hillhou

148 A four-membered oxygen ring (oxetane) can be readily grafted in

149 the ligand, indicating the ability of the 18-membered P(4)N(2) macrocycles to stereoisomerize in the

150 The obtained 18-membered P(4)N(2) macrocycles were isolated in pure form

151 uiv of carbon monoxide to give a cyclic five-membered P(=O)-CH(2)-B compound, the product of reductiv

152 yclic scaffold represents a departure from 6-membered P,N-ligands that facilitates tuning and enables

153 amine, a process that occurs through a four-membered palladacyclc intermediate.

154 nd C(sp(3))-H activation leading to the four-membered palladacycle intermediate and the cyclopropane

155 pathway to favor the formation of the [5,6]-membered palladacycle intermediate, Int-IV.

156 -limiting and formation of the strained four-membered palladacycle is thermodynamically uphill.

157 valates, which are in equilibrium via a five-membered palladacycle.

158 The evolution of the [6,6]-membered palladacycles (Int-4) are elucidated and are ac

159 lation is C-C bond formation through a seven-membered pericyclic transition state.

160 The seven-membered phosphorus heterocycles can be electrochemicall

161 temperature, which was used to generate six-membered phosphorus heterocycles via hetero Diels-Alder

162 etic procedure to prepare pai-extended seven-membered phosphorus heterocycles, both symmetric and asy

163 mentioned tautomeric systems that have seven-membered quasi rings stabilized by Li(+) ions bridging t

164 F and (2S,5R,8R)-dechlorogreensporone F, 14-membered resorcylic acid lactones with a cis-2,5-disubst

165 The mechanistic study revealed five-membered rhodacycle with quinoline N-oxide as a key inte

166 Ti sites are confined within the smaller 12-membered ring (12-MR) micropores of Ti-Beta.

167 s (net-cBUs), 12-connected (12-c) double six-membered ring (d6R) building units.

168 ck-Matsuda reaction of five-, six- and seven-membered ring alkenes and aryl diazonium salts is presen

169 either two eight-membered rings or an eight-membered ring and an imidazolone ring are also detailed.

170 nsists of two benzene rings joined by a four-membered ring at its core.

171 ort a photochemical strategy to obtain seven-membered ring benzosultams in one step, using saccharin

172 competition between the formation of a five-membered ring by ortho-attack at the armchair edge and f

173 at the armchair edge and formation of a six-membered ring by peri-attack at the zigzag edge clearly

174 ion, only the formation of the strained four-membered ring can be achieved instead of the thermodynam

175 lmaleimide is isolated for the five- and six-membered ring cases.

176 iminium ion formation, and seven- and eight-membered ring catalysts are more active than smaller rin

177 philic group affects the possibility of a 10-membered ring closure by the Nicholas reaction.

178 The synthesis of a seven-membered ring compound containing a phenol ether moiety

179 chalcogens led to the conversion of the four-membered ring core, Ni(mu-E(PhX))(mu-S'(N2))Fe, to a fiv

180 Indoles with a deactivated five-membered ring could also take part in the reaction with

181 ion of a fused-ring benzazirine into a seven-membered ring cyclic ketenimine.

182 it of the 3-sila-1,2,4-trioxepane yields six-membered ring diisopropylsilylene acetals.

183 -position versus a topologically similar six-membered ring formation at the armchair edge reveals tha

184 attack at the zigzag edge clearly favors six-membered ring formation.

185 )Si(II)]Ge(I)}(2)Ni(II) complex with a three-membered ring Ge(2)Ni-metallacycle was obtained via redu

186 dular access to a diverse collection of nine-membered ring heterocycles in a one-pot cascade and with

187 ent a facile synthesis of a substituted five-membered ring in flames and stellar outflows.

188 d malachite green possessing a central eight-membered ring in three steps.

189 m the conformation adopted by a formal eight-membered ring including both N and O atoms (i.e., crown,

190 Incorporation of a five-membered ring into a helicene framework disrupts aromati

191 coupling approach, wherein the central seven-membered ring is synthesized at a late stage.

192 logs revealed that TylHI strictly prefers 16-membered ring macrolides bearing the deoxyamino sugar my

193 core, Ni(mu-E(PhX))(mu-S'(N2))Fe, to a five-membered ring Ni-O-E-Fe-S', where an O atom inserts betw

194 yrimidine nucleobases, ranging from 5- to 12-membered ring nucleoside analogs, are generated in excel

195 ed and further elaborated into the final six-membered ring nucleosides via nucleobase incorporation a

196 ate, the reaction occurs at the central four-membered ring of biphenylene.

197 budding sites suggest that formation of a 12-membered ring of ESCRT-I molecules is a geometry-depende

198 al characterizations of the cyclic 6- and 12-membered ring precursors are also described.

199 bond-localization within the connecting six-membered ring resulted in reduced antiaromaticity of bot

200 ylation of the C(sp(2))-H bond enabling five-membered ring ruthenacycle intermediates, the cyclic imi

201 tly thermodynamically disfavored in the five-membered ring series.

202 ate, providing a means to convert a simple N-membered ring substrate to either n+1 or n+2 ring adduct

203 ed by reversible photocyclization to a seven-membered ring system (formed as a mixture of diastereome

204 from the generation of a highly strained ten-membered ring system(8,9).

205 tion and formation of a highly strained four-membered ring system.

206 on to alkylate at C2, crafting a fused seven-membered ring that is characteristic of the pentacyclic

207 he diastereoselective formation of the seven-membered ring through a Friedel-Crafts triflation and a

208 macophore tolerates ring expansion of the 13-membered ring to 14-,15-, and 16-membered rings containi

209 In the case of benzylamine, the eight-membered ring transition structure that leads to the pro

210 of the pinacol group was observed in the six-membered ring transition structure toward the allenylami

211 cally characterized PMPs containing an eight-membered ring with their solution-state optical properti

212 It is the second C(7)H(7) isomer with a five-membered ring yet to be detected, the other being vinylc

213 2)NH and R(2)NH(2)(+) groups on the same six-membered ring, behaving both as an electron donor and an

214 introduced at the N(1) position of the five-membered ring, potentially mimicking any residues.

215 2] cycloaddition of the formed six- or seven-membered ring-fused cyclopentadiene system, and a final

216 and a linear topology via an unsaturated six-membered ring.

217 with fixed envelope conformation of the five-membered ring.

218 with concomitant re-aromatization of the six-membered ring.

219 give rise to the desired N-heterocyclic four-membered ring.

220 for selectivity toward the five- or the six-membered ring.

221 n/alkyl-Suzuki coupling used to close the 11-membered ring.

222 new stereogenic center on the C2 of the five-membered ring.

223 ed radical-mediated ring contraction of five-membered-ring alkenyl boronate complexes into cyclobutan

224 We report that the silylation of five-membered-ring heteroarenes occurs with high sterically d

225 eophiles, including (1) unhindered, (2) five-membered-ring N-heterocycle-containing, and (3) alpha-te

226 enes, which can be converted into other five-membered-ring scaffolds with up to five contiguous stere

227 has been designed to construct bridged seven-membered-ring systems that are otherwise challenging to

228 Seven-membered-ring trans-alkenes undergo rapid, uncatalyzed c

229 a transition states involving six- and seven-membered rings (1,5 and 1,6 H-shifts, respectively) of a

230 The scarcity of 8- to 12-membered rings among clinically approved drugs is indica

231 rganic synthesis(2) for the formation of six-membered rings and are now well-established in biosynthe

232 d N-heterocycles, comprised of six-and seven-membered rings and is of high significance in the contex

233 This versatile route converts five- to six-membered rings and provides a detailed view of high temp

234 can also be extended to the formation of six-membered rings and to N-homoallylindoles.

235 nyl)thiophenes having five-, six-, and seven-membered rings are aromatized benzothiophene products, w

236 reactions, cycloadditions that generate five-membered rings are comparatively limited in scope.

237 The steric effects of substituents on five-membered rings are less pronounced than those on six-mem

238 Whereas six-membered rings are readily accessible from Diels-Alder r

239 hiophene products, whereas eight- and twelve-membered rings are un-rearranged adducts.

240 the same pattern of cyclization provided six-membered rings as an illustration of the reactivity of a

241 rings are less pronounced than those on six-membered rings because of the difference in bond angles.

242 hromophores that are linked between two five-membered rings can access planarized structures with red

243 While formation of 5- and 6-membered rings can be achieved from the free alcohols us

244 n of the 13-membered ring to 14-,15-, and 16-membered rings containing beta(3)-homo amino acids with

245 he cyclization delivered either five- or six-membered rings depending on the temperature of the exper

246 silanolate, allylic acetate precursors to 5-membered rings display distinct modes of activation.

247 A concise synthesis of quinoline-fused eight-membered rings from simple starting materials is describ

248 ng molecules with substructures such as five-membered rings from training spaces nevertheless produce

249 (S)-cis configuration of the two central six-membered rings in protoberberine BIA compounds.

250 ologies which convert readily available five-membered rings into strained four-membered rings.

251 with the fraction of H(+) sites sharing six-membered rings of chabazite (CHA) zeolites.

252 , resulting in weaker aromaticity of the six-membered rings of the buckybowl skeleton.

253 hlorin-type PMPs containing either two eight-membered rings or an eight-membered ring and an imidazol

254 The existence of five-membered rings results in a bowl-shaped geometry, as rev

255 ibes the ring opening of more reactive three-membered rings substituted with unsaturations with a par

256 al carbon scaffolds comprising six- and four-membered rings that pack within a pseudosquare lattice p

257 ng process for cascade formation of two five-membered rings through spiroannulation followed by cycli

258 tead of the thermodynamically favorable five-membered rings under appropriate conditions.

259 Lactones containing five-, six-, and seven-membered rings were successfully synthesized, and no ove

260 es ranging in size from twelve- to seventeen-membered rings were synthesized in moderate to high yiel

261 t in five-, six-, seven-, eight-, and twelve-membered rings with substituted N-phenylmaleimides are c

262 been applied for the synthesis of 12- to 23-membered rings with varying amino acid compositions in o

263 arrangement of substituents on one of its 5-membered rings, a pattern shared by a number of other te

264 and oxygen medium rings, in particular nine-membered rings, epitomize a unique area of chemical spac

265 carried out to form seven-membered and eight-membered rings, giving rise to tetranitro dipyrazolo-1,3

266 ontribution adds novel PMPs containing eight-membered rings, highlights the effects these derivatizat

267 trialkoxyphenyl-substituted alkynes into six-membered rings, i.e., tetrahydropyridines, was developed

268 tramolecular hydroacylation has favored five-membered rings, in preference to four membered rings.

269 ving five-, six-, seven-, eight-, and twelve-membered rings, the un-rearranged dibenzothiophene Diels

270 e internal SiC(2) and two outer M-Si-C three-membered rings, which are fused via two Si-C bonds.

271 Three- and four-membered rings, widespread motifs in nature and medicina

272 highly substituted nitrogen-containing seven-membered rings-azepanes.

273 oxamide oxygens within Mn-mu-S-CH(2) -C-O, 5-membered rings.

274 d for the synthesis of highly strained, four-membered rings.

275 lable five-membered rings into strained four-membered rings.

276 isolated open nickel(II) sites in their six-membered rings.

277 (ABA) and ten (ANA) consecutively fused six-membered rings.

278 ms consisting of fused Huckel or Mobius four-membered rings.

279 ed as benzenoids, consisting of only fused 6-membered rings.

280 nt simultaneous construction of the two five-membered rings.

281 s are mainly described to give five- and six-membered rings.

282 o enables the synthesis of 3-, 5-, 6-, and 7-membered rings.

283 d five-membered rings, in preference to four membered rings.

284 their influence on the conformations of six-membered rings.

285 lation of the C(sp(2))-H bond via larger six-membered ruthenacycle intermediates.

286 henium-catalyzed C-H bond alkylation via six-membered ruthenacycles is presented.

287 5) to rapidly assemble 4 -, 5 -, 6 -, and 7 -membered saturated nitrogen heterocycles in excellent yi

288 The molecular structure reveals a four-membered Si(4)-dication in an almost perfect square-plan

289 d oxidation product 5, bearing a central six-membered Si(4)O(2) ring.

290 2020, 59, 12395) and provides cyclic 5-membered sulfamide products in up to 98% yield and up to

291 Their core is built on the stable 26-membered tetraamidic macrocyclic scaffold, whereas vario

292 iodocyclocarbamation reaction for making six-membered tetrahydro-3-aryl-1,3-oxazin-2-ones.

293 The formation of chiral 5- and 7-membered tetrahydrofurans and tetrahydrobenzo[ d]oxepine

294 g our previously published synthesis of five-membered tetramic acid analogues to six-membered cycles.

295 e ligation proceeds via formation of a seven-membered transition state to afford di-, tetra-, and pen

296 two terminal PKS modules that produce the 16-membered tylosin macrocycle, using them as biocatalysts

297 on results in the formation of five- and six-membered unsaturated carbocycles.

298 Employing a common method from the same nine-membered unsaturated lactam precursor, we developed cond

299 rdination to Y(III) results in a distorted 4-membered YPN(2) ring.

300 hrough an enantioselectivity-determining six-membered Zimmerman-Traxler-type transition state, rather