ライフサイエンスコーパス: membrane lipid

1 pletion in cardiolipins compared to the bulk membrane lipid.

2 in contrast to an overall decrease in total membrane lipid.

3 endocytosis is specialized for transport of membrane lipid.

4 membranes, constituting up to 50% of plasma membrane lipids.

5 r formation is dependent on association with membrane lipids.

6 may protect the cell by "cross-linking" the membrane lipids.

7 ructures are rarely resolved in complex with membrane lipids.

8 stable dimers and do not selectively retain membrane lipids.

9 revealed clade-specific gene sets regulating membrane lipids.

10 teraction by influencing the organization of membrane lipids.

11 et poorly studied molecules among biological membrane lipids.

12 ed by a novel negative-feedback mechanism on membrane lipids.

13 tion should be extendable to other important membrane lipids.

14 erol dibiphytanyl glycerol tetraether (GDGT) membrane lipids.

15 r, little is known about their regulation by membrane lipids.

16 ng spectra from dispersions of the extracted membrane lipids.

17 nvolved gangliosides GT1b and GD1a and a few membrane lipids.

18 simulations suggest altered VSD exposure to membrane lipids.

19 way further contact with the polar group of membrane lipids.

20 oinositides, represent a small percentage of membrane lipids.

21 g to produce milligram quantities of nuclear membrane lipids.

22 F302L alters the exposure of S4 residues to membrane lipids.

23 a propensity to form a helix upon binding to membrane lipids.

24 synthesis and export of mycobacterial outer membrane lipids.

25 . baumannii complex organisms based on their membrane lipids.

26 s position and integrity with native E. coli membrane lipids.

27 tions in the distribution and composition of membrane lipids.

28 otherwise known for their abilities to bind membrane lipids [21, 22] and scaffold protein complex fo

29 t, rather, was mediated by a range of acidic membrane lipids, a functional interaction between PI(4,5

30 As a result, oxidized membrane lipids accumulate, leading to cell death throug

31 Membrane lipids act as solvents and functional cofactors

32 this system expands the known repertoire of membrane lipids acting as substrates for amino acid modi

33 Membrane lipids affect the innate immune response, which

34 t activity, as detected by the protection of membrane lipids against oxidation and superoxide radical

35 Outer membrane lipid alterations of current microbiological in

36 Aminoacylation of membrane lipids alters the biochemical properties of the

37 bial biomass at this depth, as determined by membrane lipid analysis.

38 early steps of biosynthesis of lipid A, the membrane lipid anchor of lipopolysaccharide.

39 of AP-2 in the maintenance of proper apical membrane lipid and cell wall composition is further supp

40 -localized GPAT enzyme responsible for plant membrane lipid and oil biosynthesis.

41 astic differences between viral and cellular membrane lipid and protein compositions and curvatures e

42 ature combined with functional modulation by membrane lipid and water vestibules.

43 amily F-BAR domain proteins bind directly to membrane lipids and are associated with actin dynamics a

44 oration of serine during the biosynthesis of membrane lipids and because lipid composition of HIV par

45 cytokinesis is essential for the delivery of membrane lipids and cargoes to the division site.

46 Membrane lipids and cellular water (soft matter) are bec

47 o PM) undergo a similar regulation by plasma membrane lipids and cytosolic Ca(2+).

48 n, and evidence of chemical modifications of membrane lipids and functional modulation of membrane pr

49 ade, in part, from hydrolysis of chloroplast membrane lipids and in part, by a continual transfer of

50 ion includes direct interaction of NM2s with membrane lipids and indirect interaction by association

51 omains are driven by intrinsic properties of membrane lipids and integral as well as membrane-associa

52 idylethanolamine is one of the most abundant membrane lipids and is particularly enriched in the brai

53 approximately 90% of SH2 domains bind plasma membrane lipids and many have high phosphoinositide spec

54 specific example of how interactions between membrane lipids and membrane-bound proteins can influenc

55 idence is growing that changes to individual membrane lipids and proteins also contribute, substantia

56 tated by domains enriched in specific plasma membrane lipids and proteins that resemble liquid-ordere

57 which cells exchange large amounts of outer membrane lipids and proteins upon contact.

58 OS damage mitochondrial proteins, mtDNA, and membrane lipids and release them in the cytosol.

59 ng, suggesting a dynamic competition between membrane lipids and RNA for the same binding sites in NC

60 ubstrates for beta-oxidation, precursors for membrane lipids and signaling molecules.

61 trol that determines acyl chain flux between membrane lipids and triglycerides during nitrogen stress

62 nergistically activated by interactions with membrane lipids and ubiquitin.

63 ed in the biosynthesis and transport of FAs, membrane lipids, and 2-MAG in rhizobia-soybean symbioses

64 ne and sphingomyelin specifically over other membrane lipids, and that cell surface binding and inter

65 hexaenoic acid is robustly incorporated into membrane lipids, and this incorporation leads to signifi

66 Membrane lipids are asymmetrically distributed.

67 ence that distinct interactions of UapA with membrane lipids are essential for ab initio formation of

68 lt-sensing mechanism might imply that plasma-membrane lipids are involved in adaption to various envi

69 r membrane molecular organization is how the membrane lipids are packed.

70 % of cellular dry weight, and 86-100% of the membrane lipids are replaced with amino- or glycolipids.

71 The receptors, along with membrane lipids, are normally returned to the plasma mem

72 Myr insertion is involved in the sorting of membrane lipids around the protein-binding site to prepa

73 t of hydrophobic and ionic interactions with membrane lipids as well as of specific protein-protein i

74 changes in the degree of saturation of their membrane lipids, as was observed by the increasing inten

75 ction of Gin4 is highly localized control of membrane lipid asymmetry and is necessary for optimal cy

76 The Mla pathway maintains outer membrane lipid asymmetry by transporting phospholipids b

77 together with the Mla system preserves outer membrane lipid asymmetry.

78 r that is important for maintenance of outer membrane lipid asymmetry.

79 ergent n-dodecyl-beta-maltoside (beta-DM) or membrane lipids, at (+)-447 and (-)-494 nm.

80 In cellular membranes, lipid autoxidation (peroxidation) is linked w

81 tion likely involves sequestering vulnerable membrane lipids away from reactive oxygen species.

82 imply that an interplay between TIL, charged membrane lipids, BAR domain, and SH3 domain could exist

83 ulations and polar headgroup compositions of membrane lipids between the epipelagic (</= 100 m) and d

84 proteins requires their extraction from the membrane lipid bilayer and subsequent proteasome-mediate

85 Although the properties of the cell plasma membrane lipid bilayer are broadly understood to affect

86 rged regions in SNARE proteins in the plasma membrane lipid bilayer to facilitate docking of vesicles

87 still considered mere building blocks of the membrane lipid bilayer, but the subsequent realization t

88 cess between the water-filled translocon and membrane lipid bilayer, suggesting that partitioning is

89 studied pHLIP ICG interaction with the cell membrane lipid bilayer, the pharmacology and toxicology

90 of new protein functional states within the membrane lipid bilayer.

91 ges in interactions of the TM helices of the membrane lipid bilayer.

92 ermeability is the formation of pores in the membrane lipid bilayer.

93 RE proteins in synaptic or secretory vesicle membrane lipid bilayers with positively charged regions

94 Our data indicate that impairment of the membrane lipid binding activity of Cb and a consequent d

95 atalytic inhibition, and increased p110alpha membrane lipid binding.

96 sphatidic acid (PA), a central metabolite of membrane lipid biosynthesis and the product of the phosp

97 y acid (FA), 2-monoacylglycerol (2-MAG), and membrane lipid biosynthesis and transport during nodule

98 These data show that active FA, 2-MAG and membrane lipid biosynthesis are essential for nodulation

99 Regulation of membrane lipid biosynthesis is critical for cell functio

100 Glycolysis, FA and membrane lipid biosynthesis were repressed in GmLEC2a-OE

101 temperature variability using bacterial cell membrane lipids (branched glycerol dialkyl glycerol tetr

102 ranes; these included nucleotide catabolism, membrane lipid breakdown and increased creatine metaboli

103 reveal a crucial role for TAG metabolism in membrane lipid breakdown, fatty acid turnover, and plant

104 rum lysolipids, potentially originating from membrane lipid breakdown.

105 4,5)P2) is a minor component of total plasma membrane lipids, but it has a substantial role in the re

106 y 4E10 suggest that 4E10 also interacts with membrane lipids, but the antibody regions contacting lip

107 and for trafficking of membrane proteins and membrane lipids, but the role of asymmetry in regulating

108 tochastic but localized dephosphorylation of membrane lipids can drive lattice disassembly.

109 Membrane lipids can regulate many signalling pathways by

110 The osmolyte trehalose and membrane lipid cardiolipin accumulate in E. coli cells c

111 Cell envelope outer membrane lipids change systematically from hydrophilic l

112 is and the synthesis of FAs, 2-MAG, TAG, and membrane lipids compared to GmWRI1b-OE hairy roots.

113 ty of pathogenic aPLs retain reactivity with membrane lipid components and rapidly induce reactive ox

114 ty and specificity through interactions with membrane lipid components.

115 dome with 118 different lipids suggests that membrane lipid composition and adaptation mechanisms in

116 crease from 15 degrees C to 25 degrees C and membrane lipid composition assessed.

117 How membrane lipid composition in turn defines the functiona

118 asma membrane properties, demonstrating that membrane lipid composition is a biochemical control para

119 in response (UPR) exclusively when normal ER membrane lipid composition is compromised, we identified

120 The membrane lipid composition is tightly regulated by the c

121 that, on the evolutionary scale, changes in membrane lipid composition may necessitate extensive ada

122 d by the scarcity of comparative data on the membrane lipid composition of cultivated representatives

123 , the detailed analysis of the corresponding membrane lipid composition of differentiated cells was p

124 homodimer peptide structure as a function of membrane lipid composition or the presence of an anionic

125 showed that molecular genetic alterations in membrane lipid composition result in many phenotypes, an

126 23-55 monomer and homodimer as a function of membrane lipid composition using a multiscale simulation

127 Membrane lipid composition varies greatly within submemb

128 ink between the major energy-sensing kinase, membrane lipid composition, and transcription.

129 t some forms of signaling require a distinct membrane lipid composition, found at cilia.

130 ric C991-55 is relatively insensitive to the membrane lipid composition, in agreement with experiment

131 proteins in the dynamic regulation of cilia membrane lipid composition, morphology, and signaling pr

132 order to correlate the viscosity values with membrane lipid composition, the detailed analysis of the

133 cally responsive to post-assembly changes in membrane lipid composition.

134 particle infectivity involves alterations of membrane lipid composition.

135 cause it is difficult to manipulate cellular membrane lipid composition.

136 hanging climate, can be observed in terms of membrane lipid composition.

137 ed alongside the complexity and diversity of membrane lipid composition.

138 e lipid bilayer can be largely determined by membrane lipid composition.

139 wn blocks phospholipid synthesis and changes membrane lipid compositions that ultimately induce the a

140 Thylakoid membrane lipids, comprised of glycolipids and the phosph

141 tional analyses of approximately 5000 plasma membrane lipid constituents of 273 species in the three

142 e levels, promotes cell growth, and elevates membrane lipid content.

143 te a significant fraction of cellular plasma membrane lipid content.

144 P mobilization through membrane lipid degradation is mediated mainly by two gly

145 , other amino acid residues (E321/E324), and membrane lipids, depending on the gate status.

146 The effect of Lti30 on membrane lipid diffusion was studied on fluorescently la

147 Each species explores membrane lipid diversity within a genetically predefined

148 rine and mitochondrial alanine metabolism to membrane lipid diversity, which further sensitizes tumou

149 The membrane lipid does have a minor role by modulating the

150 essfully monitored rapid encounter events of membrane lipid domains using flow cytometry and fluoresc

151 ly used fluorescence probe for studying cell membrane-lipids due to its affinity toward the acyl chai

152 ion and to preserve interactions with native membrane lipids during purification.

153 Membrane lipid dynamics must be precisely regulated for

154 urface and hydrophobic interactions with the membrane lipids enable intracellular delivery or cell ly

155 Altogether, our results demonstrate how the membrane lipid environment influences membrane protein t

156 Thus, ORP family members create a nanoscale membrane lipid environment that drives PIP5K activity an

157 oteins, or from the difference between their membrane lipid environments.

158 lamellar vesicles (GUVs) made of erythrocyte membrane lipids (erythro-GUVs) when exposed to the deter

159 -organellar junctions and perturbed intended membrane lipids exclusively at select membrane contact s

160 We found that the nuclear membrane lipid extract is composed of a complex mixture

161 Experiments using a native membrane lipid extract showed that the SMA copolymer doe

162 isms of acid stress mitigation: 1) change in membrane lipid fatty acid composition, 2) change in peri

163 owever, to accumulate both TAG and essential membrane lipids, fatty acid flux through nonengineered r

164 the cellular physiological role that plasma membrane lipids, fatty acids and sterols play in various

165 omparing MALDI-TOF mass spectra of microbial membrane lipid fingerprints to identify ESKAPE pathogens

166 iate in the mobilization of fatty acids from membrane lipids for peroxisomal beta-oxidation under pro

167 etter understand the role of these important membrane lipids for the bilayer properties of StnII.

168 ronment by altering the composition of their membrane lipids, for example, by modification of the abu

169 Hopanoids are a class of membrane lipids found in diverse bacterial lineages, but

170 We also show that the polar membrane lipid fraction of SL-induced LDs is rich in pla

171 (EASI) -MS was used to rapidly profile cell membrane lipids from cells spotted directly on a glass s

172 Cooling alters the membrane lipids from the fluid to gel phase, and also ca

173 try by selection and transfer of a subset of membrane lipids from the lumenal or exofacial leaflet to

174 Our understanding of membranes and membrane lipid function has lagged far behind that of nu

175 Sphingolipids are membrane lipids globally required for eukaryotic life.

176 ed cells were similar, indicating that outer membrane lipids govern overall hydrophobicity.

177 lin's BIN/Amphiphysin/Rvs domain and anionic membrane lipids have been considered the major driving f

178 to their membrane fraction, did not involve membrane lipids, heme, or iron, and was enhanced after r

179 phospholipase A (OmpLA) is involved in outer-membrane lipid homeostasis and bacterial virulence.

180 um (ER) and other membranes help to maintain membrane lipid homeostasis.

181 to visualize and analyze the distribution of membrane lipids in an increasingly large number of appli

182 her determined the roles of cytoskeleton and membrane lipids in DRG neuron mechanics.

183 ds that comprise a minor proportion of total membrane lipids in eukaryotic cells but influence a broa

184 osition and fluxes of 62 nitrogen-containing membrane lipids in human hepatoma HepG2 cells.

185 edge on the interactions of polyphenols with membrane lipids in in vitro models and the underlying ch

186 osphatidylcholine (PC) is a primary class of membrane lipids in most eukaryotes.

187 storage lipids rather than phospholipid (PL) membrane lipids in neurons.

188 n seedlings and mature siliques and of major membrane lipids in seedlings and triacylglycerol in matu

189 g, adapted to specifically removing HFA from membrane lipids in seeds.

190 However, the roles of membrane lipids in the formation of pores and their biol

191 Although recent studies suggest a role for membrane lipids in the modulation of class A and class F

192 nal region of vIRF-1 interacts directly with membrane lipids, including cardiolipin.

193 ed fatty acids are rapidly incorporated into membrane lipids, inducing a reduction in membrane packin

194 rhodopsin as an archetype for understanding membrane lipid influences on conformational changes invo

195 Membrane lipids interact with proteins in a variety of w

196 ed by protein structural requirements and/or membrane lipid interactions, and these new insights will

197 ing the viral infection, gB interaction with membrane lipids is still poorly understood.

198 Archaeal membrane lipids known as glycerol dibiphytanyl glycerol

199 ed the molecular composition of yeast plasma membrane lipids located within a defined diameter of mod

200 ronal exocytosis binds to negatively charged membrane lipids (mainly phosphatidylserine (PtdSer) and

201 d by oligodendrocyte dysfunction and altered membrane lipid metabolic flux as drivers of neurodegener

202 sicle trafficking, defense signaling through membrane lipid metabolism and mucilage production.

203 ivity was expressed, the formation of plasma membrane lipid microdomains and the number of exocytotic

204 nal function depends on the integrity of the membrane lipid microenvironment.

205 tudies indicate that Lpcat3 activity impacts membrane lipid mobility in living cells, suggesting a bi

206 These membrane lipid modifications were investigated in glucos

207 imulation data suggest that, in a biological membrane, lipid molecules occupy this periplasmic exit a

208 ane expansion, during which the synthesis of membrane lipids must be tightly regulated.

209 Membrane lipids of marine planktonic archaea have provid

210 Here we show that membrane lipids of marine planktonic archaea reliably re

211 n E by interference with binding to specific membrane lipids or by altering cellular structures such

212 In addition, Golgi membrane lipid order disruption byd-ceramide-C6 causes G

213 Osh protein-mediated unsaturated PI4P and PS membrane lipid organization is sensed by the PIP5K speci

214 effectors through Abca1-dependent changes in membrane lipid organization that disrupt the recruitment

215 usitatissimum) phenolic compounds to prevent membrane lipid oxidation.

216 make electrostatic interactions with nearby membrane lipid oxygen atoms.

217 ter-holding capability and reduced levels of membrane lipid peroxidation and electrolyte leakage unde

218 y, reactive oxygen species (ROS) generation, membrane lipid peroxidation, membrane fluidity, intracel

219 lysis and antioxidant activity by inhibiting membrane lipid peroxidation.

220 , Gpx4-deficient T cells rapidly accumulated membrane lipid peroxides and concomitantly underwent cel

221 via lateral fenestrations connecting to the membrane lipid phase, as well as via an aqueous pathway

222 t2 positions the ER and Sac1, an integral ER membrane lipid phosphatase, in discrete ER-PM junctions.

223 osperm, even though it is synthesized on the membrane lipid phosphatidylcholine (PC) from an oleoyl e

224 Here, we show that the membrane lipid phosphatidylinositol 4,5-bisphosphate (PI

225 relies on allosteric actions of agonist and membrane lipid phosphatidylinositol 4,5-bisphosphate (PI

226 c2beta bind the dynamically regulated plasma membrane lipid phosphatidylinositol 4,5-bisphosphate (PI

227 binding sites for both cooling agonists and membrane lipid phosphatidylinositol 4,5-bisphosphate [PI

228 The membrane lipid phosphatidylinositol-3,4-bisphosphate (PI

229 Kir2.2 has multiple interactions with plasma membrane lipids: Phosphatidylinositol (4, 5)-bisphosphat

230 s non-apoptotic cell surface exposure of the membrane lipid phosphatidylserine (PS).

231 related to autoimmune antibodies against the membrane lipid phosphatidylserine (PS).

232 mperature and is positively regulated by the membrane lipid PIP(2).

233 r-pore coupling and pore opening require the membrane lipid PIP2 and intracellular ATP, respectively,

234 y pathway and sheds light onto the role that membrane lipids play in regulating transport across the

235 osate (PDIM), one of the most abundant outer membrane lipids, plays important roles in both defending

236 these lipids and the cellular regulation of membrane lipid polymorphism in bacteria.

237 caused decreases in unsaturation indices of membrane lipids, primarily due to decreases in highly-un

238 Analysis of bacterial membrane lipid profiles revealed that the esxC mutant wa

239 ncept that the oxidations disrupt corneocyte membrane lipids, promoting release of free omega-hydroxy

240 its polybasic region and negatively charged membrane lipids provided by ATP8B1.

241 dly associates with TLR4 and translocates to membrane lipid raft domains.

242 SLs in breast cancer cells form a complex in membrane lipid raft with caveolin-1 (CAV1) and focal adh

243 ncreased hippocampal expression of Cav-1 and membrane/lipid raft localization of postsynaptic density

244 Membrane lipid rafts (MLRs) within the plasma membrane o

245 The distribution of membrane lipid rafts and adhesion receptors were analyze

246 PrP(C)) resides in detergent-resistant outer membrane lipid rafts in which conversion to the pathogen

247 We find that apoA1 rapidly disrupts membrane lipid rafts, and as a consequence, dampens the

248 ciated with a clustering of CD44 and CD24 in membrane lipid rafts, leading to the activation of Src F

249 ed cellular cholesterol and disrupted plasma membrane lipid rafts, similar to positive control methyl

250 Here we show that soluble klotho binds membrane lipid rafts.

251 its interaction with cholesterol present in membrane lipid rafts.

252 Studies in vitro demonstrate that neuronal membrane/lipid rafts (MLRs) establish cell polarity by c

253 plasmalemmal signaling microdomains, termed membrane/lipid rafts (MLRs).

254 tudies in vitro and in vivo demonstrate that membrane/lipid rafts and caveolin (Cav) organize progrow

255 a incorporate extracellular fatty acids into membrane lipids, raising the question of whether pathoge

256 ipts encoding proteins involved in thylakoid membrane lipid recycling suggested more abrupt repartiti

257 in the interactions of ceramides with other membrane lipids, reflecting possible functional implicat

258 ience provides further insights into general membrane lipid remodeling-based stress tolerance mechani

259 Choline treatments could restore the membrane lipids, repair cellular organelles and protect

260 trajectories and optogenetic manipulation of membrane lipids revealed that Rac1 membrane translocatio

261 iling reveals that SNX14 (KO) cells increase membrane lipid saturation following exposure to palmitat

262 Both, thaumarchaeal quinones and membrane lipids showed similar distributions with maxima

263 enous acetate, with considerable turnover of membrane lipids, so that total lipid rather than TAG is

264 use the surrogate partition coefficients for membrane lipid, storage lipid, protein, and carbohydrate

265 Further inspection of membrane lipid structures affecting physicochemical prop

266 by inhibitor, recycling receptors and plasma membrane lipids, such as transferrin receptors and sphin

267 f pathways overlaps with those for essential membrane lipid synthesis and utilizes multiple different

268 types, consistent with the role in essential membrane lipid synthesis.

269 s involves its ability to protect changes in membrane lipids that are proferroptotic.

270 conformations favor such curvature and host membrane lipids that permit horseshoe conformations are

271 ark salt gland and bilayers of the extracted membrane lipids, the D2O-ESEEM intensities of fully char

272 t of metabolic pathways for the synthesis of membrane lipids; therefore most lipid species and their

273 ement with their proposed role in protecting membrane lipids, TILs have been reported to be associate

274 PLA2 attractant that works together with the membrane lipids to "lure" in-coming PLA2 for attack.

275 tional interactions with BinB or microvillar membrane lipids to bind to its intracellular target and

276 how P4-ATPases sort through the spectrum of membrane lipids to identify their desired substrate(s) a

277 reviously unappreciated route for delivering membrane lipids to lysosomes for turnover, a function th

278 ty is that dietary fats can incorporate into membrane lipids to regulate the properties and physiolog

279 ing comparable to the wild type in recycling membrane lipids to TAG but being impaired in additional

280 nover and hence fatty acid mobilization from membrane lipids to TAG.

281 secretion delivers TM proteins and recycled membrane lipids to the same apical PM domain, and (2) FM

282 the cis-unsaturated fatty acids (FAs) of the membrane lipids to their trans-isomers to rigidify the m

283 ipid A, a reaction catalyzed by the integral membrane lipid-to-lipid glycosyltransferase 4-amino-4-de

284 ABC) transporters ABCA1 and ABCG1, which are membrane lipid translocases.

285 uption of basal autophagy impedes organellar membrane lipid turnover and hence fatty acid mobilizatio

286 inovosyldiacylglycerol (SQDG), a chloroplast membrane lipid, under nitrogen-limited conditions.

287 embedded in amphipathic environments such as membranes, lipid vesicles, detergent micelles, bicelles,

288 Remodelling membrane lipids, via homeoviscous adaptation (HVA), coun

289 Acyl chain flux into membrane lipids was dominant in the first stage followed

290 In stripped roots, the level of major membrane lipids was not different between N-sufficient a

291 centrations in the target compartment (i.e., membrane lipids) was expected to but did not decrease th

292 effort to improve our understanding of these membrane lipids we examined phenotypes exhibited by the

293 By analyzing membrane lipids, we found that the selected alleles modu

294 Membrane lipids were continually synthesized with associ

295 that phospholipids, sphingolipids, and other membrane lipids were significantly altered in the ctl1 m

296 oph Pelagibacter sp. str. HTCC7211 renovates membrane lipids when phosphate starved by replacing a po

297 Ornithine lipids (OLs) are phosphorus-free membrane lipids widespread in bacteria but absent from a

298 Membrane lipids with (2)H-labeled acyl chains or polar h

299 s that utilize aminoacylated tRNAs to modify membrane lipids with amino acids.

300 FA and acyl chain transfer from pre-stressed membrane lipids with little input from lipid remodeling.