ライフサイエンスコーパス: membrane permeability

1 ethylene biosynthesis, respiration rate and membrane permeability.

2 ell wall by OligoG CF-5/20 and its effect on membrane permeability.

3 AMP concentrations to the same steady-state membrane permeability.

4 membrane and that this interaction increases membrane permeability.

5 er their size, shape, surface chemistry, and membrane permeability.

6 control as a function of applied voltage and membrane permeability.

7 ole in their virulence by changing the outer membrane permeability.

8 OS levels and the resulting increase in cell membrane permeability.

9 al levels of susceptibility to SP-A-mediated membrane permeability.

10 ally similar probes that differ in color and membrane permeability.

11 ich are metabolically unstable and have poor membrane permeability.

12 event complete pore closure and lead to high membrane permeability.

13 active oxygen species formation or lysosomal membrane permeability.

14 hibited a low T1-weighted signal, due to low membrane permeability.

15 hers and its importance in maintaining outer-membrane permeability.

16 fluorescent dye, indicating that SH affects membrane permeability.

17 for cell-based studies because of their poor membrane permeability.

18 structures consistent with a pore and alters membrane permeability.

19 tramolecular hydrogen bonding with increased membrane permeability.

20 physiological pH, which may have limited its membrane permeability.

21 s engulfed prior to changes in chromatin and membrane permeability.

22 subunits significantly reduced ATP-activated membrane permeability.

23 in the low micromolar range and significant membrane permeability.

24 ng protocell constructs with self-controlled membrane permeability.

25 ack cellular activity conceivably due to low membrane permeability.

26 and hydrocortisone-covering a wide range of membrane permeability.

27 ber 2, channels had no significant effect on membrane permeability.

28 present in microbial cellulose and increase membrane permeability.

29 utrient-poor conditions without compromising membrane permeability.

30 tors reported to date, and 10 shows improved membrane permeability.

31 holine, and cholesterol) was used to measure membrane permeability.

32 s membrane blebbing and decreases changes in membrane permeability.

33 nduces both membrane blebbing and changes in membrane permeability.

34 rial potential depolarization, and plasmatic membrane permeability.

35 rythrocytes, with some contribution of a low membrane permeability.

36 ell microparticles, we find a major role for membrane permeability.

37 t have trypanocidal activity due to its poor membrane permeability.

38 e with decreased fibrosis, calcification and membrane permeability.

39 tides (AMPs) induce cytotoxicity by altering membrane permeability.

40 xicated cells, together with increased outer membrane permeability.

41 extran permeability were evaluated to assess membrane permeability.

42 ncluding increased proteolytic stability and membrane permeability.

43 he increase of plasma membrane potential and membrane permeability.

44 red through injections only, due to its poor membrane permeability.

45 ing thermal fluctuations, active forces, and membrane permeability.

46 al modulation of membrane proteins affecting membrane permeability.

47 of a substance in an organic phase with its membrane permeability.

48 spectral overlaps and temperature effects on membrane permeability.

49 chanical forces to transiently increase cell membrane permeability.

50 were found for cell wall neutral sugars and membrane permeability.

51 oechst staining assay assess only late stage membrane permeability.

52 t ganglion (DRG) exposure attributed to poor membrane permeability.

53 o modulate the transport of solutes with low membrane permeabilities.

54 substituents have, in correlation with their membrane permeability, a more pronounced antiviral activ

55 ne-conjugated bile acids, which have reduced membrane permeability, affected ENaC activity more stron

56 erms of loss of tissue volume and/or altered membrane permeability, agreeing with both hypotheses of

57 on, and caused Bnip3-dependent mitochondrial membrane permeability, AIF translocation, and neuron dea

58 causes a transient increase in their plasma membrane permeability, allowing transmembrane transport

59 yclic peptides can achieve surprisingly high membrane permeability, although the properties that gove

60 Loss of CtaP increased membrane permeability and acid sensitivity, and reduced

61 l death involved loss of mitochondrial outer membrane permeability and activation of caspases 3/7.

62 is required for loss of mitochondrial outer membrane permeability and apoptosis in cells treated wit

63 -methylation, and side chain size to passive membrane permeability and aqueous solubility.

64 The peptide induces bacterial membrane permeability and ATP release, with serial passa

65 e lipids, which in turn results in increased membrane permeability and bacterial lysis.

66 several chemical reactions to modulate their membrane permeability and binding affinity.

67 reactivity in vitro but also decreases cell-membrane permeability and biological activity, (b) the a

68 a common secretory pathway that depends upon membrane permeability and can operate in the absence of

69 At these doses, NaN3 alters mitochondrial membrane permeability and causes mitochondrial swelling

70 itochondrial blockers induced loss of plasma membrane permeability and cell death.

71 Loss of Bax/Bak reduced outer mitochondrial membrane permeability and conductance without altering i

72 led trial to investigate the effects of both membrane permeability and dialysate purity on cardiovasc

73 ibutions of membrane piercing, modulation of membrane permeability and endocytosis to cargo transfer

74 +) C. sakazakii/DC culture markedly enhanced membrane permeability and enterocyte apoptosis, whereas

75 leads to formation of a pore that increases membrane permeability and eventually causes cell death.

76 t toward the water phase, thereby increasing membrane permeability and eventually triggering cell dea

77 The membrane permeability and functionality of PCa were seve

78 that the HMPV SH protein could regulate both membrane permeability and fusion protein function during

79 lipids in control of the mitochondrial outer membrane permeability and hence mitochondrial respiratio

80 , mortalin depletion increased mitochondrial membrane permeability and induced cell death in KRAS-mut

81 Active caspase-1 increased cellular membrane permeability and intracellular calcium levels,

82 ture of the cell envelope and alterations in membrane permeability and membrane potential.

83 any component processes, such as signalling, membrane permeability and metabolic activity.

84 the mechanism of toxicity may include plasma membrane permeability and mitochondrial poisoning that l

85 aggregates are those most potent at inducing membrane permeability and most effectively inhibited by

86 gical features of muscular dystrophy, muscle membrane permeability and muscle fibrosis.

87 ding 7e, 7f, 7g, and 9k, that addressed cell membrane permeability and other physicochemical issues.

88 Membrane permeability and polarization were measured usi

89 The results show that plasma membrane permeability and potential are key factors invo

90 n hybrid core structure which enhances outer membrane permeability and reduces efflux by dissipating

91 e apoptosis through control of mitochondrial membrane permeability and release of cytochrome c.

92 les, can temporarily change vascular or cell membrane permeability and release or activate various co

93 m of Bax is sufficient to increase lysosomal membrane permeability and restore autophagic cell death

94 The membrane permeability and selective uptake of the peptid

95 mbrane provide significant increases in both membrane permeability and selectivity, offering new aven

96 can overcome the ubiquitous tradeoff between membrane permeability and selectivity; they hold great p

97 h balanced key features of tunable selective membrane permeability and structural stability for prodr

98 ysterols are known to have direct effects on membrane permeability and structure, effects that are st

99 analysing the relation between the effective membrane permeability and the applied stress, both the i

100 , deletion of both genes did not change cell membrane permeability and the oxidative and heat stress

101 indings provide a link between the increased membrane permeability and the structural heterogeneity c

102 at the mitochondrial outer membrane controls membrane permeability and thereby the apoptotic program.

103 d by using fluorescent dyes to measure outer-membrane permeability and to determine membrane depolari

104 y and the applied stress, both the intrinsic membrane permeability and UWL thickness can be determine

105 net Hg(II) accumulation by decreasing outer membrane permeability and, therefore, the passive diffus

106 gical activity may be limited by inefficient membrane permeability and/or endosomal escape.

107 n culture supernatants, alterations in outer membrane permeability, and changes in surface ultrastruc

108 The stability, neutral charge, cell membrane permeability, and favorable relative influences

109 uctions in nutrient uptake, enzyme kinetics, membrane permeability, and function of other biomacromol

110 nteractions with targets, improving cellular membrane permeability, and increasing robustness towards

111 ease BCL2 expression, increase mitochondrial membrane permeability, and induce a caspase-dependent ap

112 nstrated efficient RBC partitioning and high membrane permeability, and is not an efflux transporter

113 on of reactive oxygen species, mitochondrial membrane permeability, and mitochondrial mass, and decre

114 wed nanomolar IC50 values for both proteins, membrane permeability, and no interference with estrogen

115 iomarkers for mitochondrial activity, plasma membrane permeability, and nuclear morphology.

116 ar morphology, flow cytometry, mitochondrial membrane permeability, and pharmacological caspase inhib

117 ides with increased conformational rigidity, membrane permeability, and protease resistance.

118 physiology and function such as cell shape, membrane permeability, and protein synthesis.

119 , extracellular calcium entry, mitochondrial membrane permeability, and release of apoptosis-inducing

120 ensitivity, antiphagocytosis activity, outer membrane permeability, and sensitivity to anionic deterg

121 Moreover, BV supply is limited by membrane permeability, and smURFPs (but not BPH FPs) can

122 to intense noise caused a rapid increase in membrane permeability, and the onset of membrane leakage

123 Changes in HeLa cell morphology, membrane permeability, and viability caused by the prese

124 e regulation of epithelial barrier function, membrane permeability, and water homeostasis in the resp

125 of various proteases, inhibition mechanisms, membrane permeability, antiviral activity, and cytotoxic

126 Nontoxic nature and cell membrane permeability are key features of this probe and

127 meability values in both parallel artificial membrane permeability assay (PAMPA) and blood-brain barr

128 y was assessed using the parallel artificial membrane permeability assay (PAMPA) and Caco-2 assay, re

129 ) were studied using the parallel artificial membrane permeability assay (PAMPA) at pH 6.5.

130 eability was assessed by parallel artificial membrane permeability assay and Caco-2 assay.

131 stereoisomers using the parallel artificial membrane permeability assay and looked at differences in

132 as well as a customized parallel artificial membrane permeability assay indicated good skin permeati

133 However, through a combination of membrane permeability assays and imaging techniques we f

134 In vitro transport assays and in vivo membrane permeability assays combined with mutagenesis i

135 Artificial and cell-based membrane permeability assays provided evidence that the

136 , a rhodamine 123 retention assay, lysosomal membrane permeability assessment, and DCF (2',7'-dichlor

137 there is a significant change in spore inner membrane permeability at commitment.

138 yclic peptides displayed a steep drop-off in membrane permeability at molecular weights above 1000 Da

139 and phagocytosis; perturbation to the outer membrane permeability barrier and hypersensitivity to bi

140 mportant roles in the integrity of the outer-membrane permeability barrier and participate extensivel

141 early 1990s, it became clear that the outer membrane permeability barrier and the activity of peripl

142 deliver antibacterial cargo across the outer membrane permeability barrier of Gram-negative pathogens

143 als the contribution of the formidable outer-membrane permeability barrier that reduces the compounds

144 a means to overcome the Gram-negative outer membrane permeability barrier.

145 causing a profound defect in the cytoplasmic membrane permeability barrier.

146 ations to study the effect of cholesterol on membrane permeability, because cholesterol is abundant i

147 proteolytic degradation, altered solubility, membrane permeability, bioavailability, and especially r

148 trogen atom at physiological pH to allow for membrane permeability, but which can become protonated w

149 and causes an order-of-magnitude increase in membrane permeability by facilitating the formation of l

150 y, we show that medin oligomers induce ionic membrane permeability by pore formation.

151 hile archaeal organisms overcome problems of membrane permeability by producing lipids with structura

152 cillation physics and the resulting cellular membrane permeability by simultaneous microscopy of thes

153 s biotransformation (sulfamethoxazole), poor membrane permeability (cimetidine, colchicine) and also

154 While membrane permeability could also be induced by cationic

155 deletion of pe19, suggesting that increased membrane permeability due to PE19 overexpression sensiti

156 ease of find-me signals and selective plasma membrane permeability during apoptosis, and a new mechan

157 asmodium falciparum increases red blood cell membrane permeability during infection to allow for impo

158 The synergistic action of outer membrane permeability, efflux pump activities and enzyma

159 gent alpha-hemolysin, we have controlled the membrane permeability, enabling targeted delivery of the

160 pneumoniae, and coadministration with outer membrane permeability enhancers profoundly sensitizes Es

161 ECT uses HVEPs to transiently increase membrane permeability, enhancing cellular cytotoxic drug

162 Stress sensors monitor outer membrane permeability, envelope protein folding, and ene

163 estimates for the mean proton pumping rate, membrane permeability, etc., but, as expected, the ODE m

164 oid oligomers and protofibrils increase cell membrane permeability, eventually leading to cell death.

165 ol element also contributes to the increased membrane permeability exhibited by multicomponent-derive

166 ly amplifying advantage to proton pumping as membrane permeability falls, for the first time favoring

167 tive heteromeric hemichannels increases cell membrane permeability, favoring ATP release and Ca(2+) o

168 ocalize at the mitochondria, where it alters membrane permeability following genotoxic stress.

169 ith mitochondrial tubular assembly and outer membrane permeability for adenine nucleotides leading to

170 destroy diseased cells and/or increase cell membrane permeability for drug delivery.

171 Based on a simulation model, the membrane permeability for ferrocyanide molecules passing

172 sonoporation that transiently increases cell membrane permeability for localized delivery of DNA.

173 In particular, insufficient membrane permeability frequently limits the accumulation

174 together with additional measurements on CO2 membrane permeability from Fragilariopsis cylindrus labo

175 The ion channel-like protofibrils and their membrane permeability have also been found in other amyl

176 nd stereoselective mechanism of action, high membrane permeability, high brain penetration evaluated

177 AMPs induce membrane permeability in E. coli spheroplasts or giant u

178 ing showed that Vp1659 is required to induce membrane permeability in HeLa cells.

179 Connexons regulate membrane permeability in individual cells or couple betw

180 more, the compounds exhibited excellent cell membrane permeability in living cells and a higher selec

181 he sphingosine salvage pathway in regulating membrane permeability in the execution phase of programm

182 oton or ion channels, and in general enhance membrane permeability in the host.

183 its antimicrobial activity, rapidly inducing membrane permeability in the target pathogens.

184 is, diffusion of the NO to the membrane) and membrane permeability, in addition to intracellular diff

185 Field exposure is associated with a membrane permeability increase usually ascribed to elect

186 Yet, mitochondrial size and membrane permeability increased significantly during, bu

187 ayed both Ca(2+) deregulation and the plasma membrane permeability increases, indicating that Zn(2+)

188 lopascals, beyond which endothelial cellular membrane permeability increases.

189 rons underwent a terminal increase in plasma membrane permeability, indicated by loss of AlexaFluor-4

190 Indeed the steady-state membrane permeability induced by AMPs is quantitatively

191 The addition of TAM enhances membrane permeability, inducing calcein to translocate f

192 r via the attenuation of the acidity and low membrane permeability inherent to known nucleoside inhib

193 Once formed, membrane permeability (integrity) was unaffected by mine

194 In addition, reduced membrane permeability is a leading cause of antibiotic r

195 potoxicity, we show that outer mitochondrial membrane permeability is altered and identified a posttr

196 equent temporal propagation of mitochondrial membrane permeability is calcium-dependent.

197 Control of membrane permeability is especially important for proces

198 structural basis for cholesterol effects on membrane permeability is still unclear.

199 f event that contributes to this increase in membrane permeability is the formation of pores in the m

200 perimental evidence for electrically induced membrane permeability, its correlation with transmembran

201 ma membrane (PM) to form pores that increase membrane permeability, leading to pyroptosis and IL-1bet

202 olvent, a cryoprotectant, and an enhancer of membrane permeability, leading to the general assumption

203 from lysosomes, an event known as lysosomal membrane permeability (LMP).

204 P-C bond of methylphosphonates with the high membrane permeability, low toxicity, and improved gene s

205 r ethylene production, ACC oxidase activity, membrane permeability, <beta>-galactosidase activity and

206 enon can cause significant underestimates in membrane permeability measurements which in turn limits

207 luence conformation, pKa, intrinsic potency, membrane permeability, metabolic pathways, and pharmacok

208 ebbing of the outer membrane and increase in membrane permeability occurred in association with the c

209 icantly improved the metabolic stability and membrane permeability of 2 while retaining mu-opioid rec

210 Thus, the membrane permeability of 8-pCPT-2'-O-Me-cAMP in insulin-

211 HVEPs increase the membrane permeability of cells, a phenomenon known as el

212 transport machinery to overcome the reduced membrane permeability of diacyl lipid membranes.

213 as also important for the 'selective' plasma membrane permeability of early apoptotic cells to specif

214 The high membrane permeability of H2S was studied using polarizab

215 as found that the peptide increased the cell membrane permeability of M. arachidicola, S. cerevisiae

216 luate experimentally and computationally the membrane permeability of matched sets of peptidic small

217 orms of cell death through direct effects on membrane permeability of multiple intracellular organell

218 rmaldehyde in addition to markedly augmented membrane permeability of oocytes.

219 e stereochemistry and determined the passive membrane permeability of over 1000 novel lariat peptide

220 yses revealed that AA1 binding increases the membrane permeability of POPC/POPG liposomes, which mimi

221 The model hints that the plasma membrane permeability of the cells is not radially unifo

222 nt necrotic cell death by facilitating outer membrane permeability of the MPTP.

223 tically driven water influx, we find the H2O membrane permeability of the rod OS to be (2.6 +/- 0.4)

224 on the physical properties, particularly the membrane permeability, of the radical precursors.

225 ids give rise to a bell-shaped dependence of membrane permeability on [Chol] for very hydrophobic sol

226 l cycle arrest was not due to increased cell membrane permeability or DNA damage.

227 t initiated by increased outer mitochondrial membrane permeability or translocation of apoptosis-indu

228 tly, the Caco-2 assay also revealed improved membrane permeability over previous compounds.

229 tauri, we examined the relationship between membrane permeability, oxidative stress and chlorophyll

230 cs into cells, measuring the passive anionic membrane permeability P(ion) through planar lipid bilaye

231 port barriers by analyzing the effect of RBC membrane permeability (P(m)), hematocrit (Hct) and NO-Hb

232 orm apoptotic pores, but still enhance outer membrane permeability, permitted MPTP-dependent mitochon

233 d in lysosomes where its depletion increased membrane permeability, pH, cathepsin release, and cellul

234 Membrane permeability, phase II metabolism, and ATP bind

235 ly suffer poor proteolytic stability and low membrane permeability, posing a major pharmacological ch

236 part desirable properties such as acceptable membrane permeability, potent whole blood activity, and

237 g the IncuCyte ZOOM imaging platform and the membrane-permeability properties of two DNA dyes.

238 cus may be attributed to the changes in cell membrane permeability, protein synthesis activity, and a

239 ets mycobacterial membranes and that reduced membrane permeability provides mycobacteria intrinsic re

240 ellular alterations such as increased plasma membrane permeability, reduced resting membrane potentia

241 Their many advantages include membrane permeability, relatively small size, stoichiome

242 heir short half-life, immunogenicity and low membrane permeability, restricting most therapies to ext

243 h microbubbles can efficiently increase cell membrane permeability resulting in enhanced tissue distr

244 the design of TFN to overcome the classical membrane permeability-selectivity trade-off.

245 Two analogs with improved membrane permeability showed much increased DRG concentr

246 to protein-based nucleases that usually lack membrane permeability, significant cellular uptake and n

247 However, it has been shown that membrane permeability strongly depends on temperature an

248 the TP0453 polypeptide was found to increase membrane permeability, suggesting the molecule functions

249 is new targeting mechanism is named the cell membrane permeability targeting (CMPT) mechanism, which

250 rgeting mechanism is introduced, termed cell membrane permeability targeting (CMPT), which improves t

251 s reported by others to show increased outer membrane permeability, temperature-sensitive growth, and

252 and MexXY efflux systems) expression, outer-membrane permeability (tested with 1-N-phenylnaphthylami

253 Membrane permeability tests suggested that the baicalein

254 The results yield membrane permeabilities that are in semiquantitative agr

255 s to establish a theoretical formula for the membrane permeability that is controlled by free ion dif

256 polycationic peptide protamine, to yield the membrane permeability that is lower than the correspondi

257 that M. smegmatis lacking MmpL11 has reduced membrane permeability that results in resistance to host

258 asis it was hypothesized that differences in membrane permeability to aldopentoses provide a mechanis

259 d acidic microenvironment triggers selective membrane permeability to allow small molecules (glucose

260 ependent manner and is capable of increasing membrane permeability to ATP at even relatively low conc

261 the ability of any compound with significant membrane permeability to be applied intracellularly by w

262 tion field to be directly observed, allowing membrane permeability to be determined easily from the t

263 Furthermore, the outer membrane permeability to cephalothin and cephaloridine,

264 ocesses when we change the width of the EUF, membrane permeability to CO(2), native extra- and intrac

265 lymersome nanoreactors with tumor-pH-tunable membrane permeability to coload H(2)O(2)-responsive prod

266 inhibitors still suffered from too low cell membrane permeability to enter into CNS drug development

267 cretion of ATP that within minutes increases membrane permeability to ethidium (Etd(+)) and Ca(2+) by

268 f proteins termed viroporins, which modulate membrane permeability to facilitate critical steps in a

269 sp null strain and the extent of cytoplasmic membrane permeability to large molecules.

270 some nanoreactor with tumor-specific tunable membrane permeability to load both hydrophobic phenylbor

271 Basolateral membrane permeability to NH(3) was reduced in CDs from R

272 Pharmacological treatment that alters cell membrane permeability to potassium affected the maintena

273 idylserine exposure, caspase activation, and membrane permeability to propidium iodide in the absence

274 e fusion is accompanied by strongly enhanced membrane permeability to small molecules and a measurabl

275 The high membrane permeability to small monovalent ions is determ

276 nd behavioral effects ranging from increased membrane permeability to toxicity, microinjection of DMS

277 tochondrial changes leading to mitochondrial membrane permeability transition and AIF release.

278 and earlier formation of the calcium-induced membrane permeability transition pore.

279 ecrotic cell death mediated by mitochondrial membrane permeability transition, and open new avenues f

280 a promising class of therapeutics, but poor membrane permeability typically limits their application

281 fold less lactate dehydrogenase (a marker of membrane permeability) upon infection by invasive S. ent

282 carotenoids, and reactive oxygen species and membrane permeability using fluorescent probes (CM-H2 DC

283 lls preloaded with calcium green (CaGr), and membrane permeability, using FM1-43 dye.

284 in medicine to transiently increase the cell membrane permeability via electroporation to deliver the

285 Outer-membrane permeability was 3-4.5 times higher in RPMI 164

286 In vitro membrane permeability was assessed by parallel artificia

287 The change in membrane permeability was directly associated with the f

288 No change in membrane permeability was found at concentrations of 0.1

289 ux of auxin mediated by AUX1, expressed as a membrane permeability, was 1.5 +/- 0.3 mum s(-1) .

290 To understand the reason for the membrane permeability, we investigated the physical prop

291 ctivities, anti-fIIa activity and artificial membrane permeability were considerably improved by opti

292 analogues exhibiting improved solubility and membrane permeability were shown to have notably enhance

293 ents, plant biomass, lipid peroxidation, and membrane permeability) were not affected.

294 contribute significantly to the macroscopic membrane permeability which is similarly subject to H-bo

295 amino acid phenylalanine produces increased membrane permeability, which is likely responsible for s

296 proved salt rejection without scarifying the membrane permeability, which provides a new dimension fo

297 ons of new analogues aimed at improving cell membrane permeability while maintaining high in vitro po

298 or-donor pairs in such molecules can improve membrane permeability while retaining or improving other

299 f riboflavin (2.4-3.6 muM) and improved cell membrane permeability, with a positive correlation of Zn

300 We also find that membrane permeability would need to be above physiologic