ライフサイエンスコーパス: membrane potential

1 retained a normal KCNQ4 current and resting membrane potential.

2 ed voltages and increased I (NaP) at resting membrane potential.

3 glutamate into synaptic vesicles, driven by membrane potential.

4 ative phosphorylation coupling efficiency or membrane potential.

5 ubsequent step involving the electrochemical membrane potential.

6 h signalling through their effects on plasma membrane potential.

7 ATPase (NKA), the ion channel that maintains membrane potential.

8 ptake, but rather directly from dysregulated membrane potential.

9 uptake, without affecting the mitochondrial membrane potential.

10 e lipid II flippase activity that depends on membrane potential.

11 ygen species and protected the mitochondrial membrane potential.

12 cycle (TCA), and have abnormal mitochondrial membrane potential.

13 in real-time (every 50 us) based on myocyte membrane potential.

14 ssociated EET current leads to more negative membrane potential.

15 nces governing the dynamics of sub-threshold membrane potential.

16 nse dynamics are due to the shift in resting membrane potential.

17 signal cascade is direct action on the cell membrane potential.

18 ess and disturbances caused to mitochondrial membrane potential.

19 dent ion channels in response to a change in membrane potential.

20 burst when depolarized from a hyperpolarized membrane potential.

21 ples changes in intracellular nucleotides to membrane potential.

22 onsistent with this, decreased mitochondrial membrane potential.

23 ward the maintenance of normal mitochondrial membrane potential.

24 e single-cell time-dynamics of mitochondrial membrane potential.

25 ation and move at slower timescales than the membrane potential.

26 et, inserting into a membrane and disrupting membrane potential.

27 varying voltages 0-80 mV positive to resting membrane potential.

28 lectivity of the hair cell by modulating its membrane potential.

29 nner consistent with a temperature dependent membrane potential.

30 oxygen species generation and mitochondrial membrane potentials.

31 lar respiratory activities and mitochondrial membrane potentials.

32 esterol concentration and intrinsic electric membrane potentials.

33 xpectedly enhanced LTCC opening at polarized membrane potentials.

34 a(v) activity is shifted to more-depolarized membrane potentials.

35 d to Na(+) is to serve as a mere mediator of membrane potential(10).

36 rexpressing ACE have increased mitochondrial membrane potential (24% higher), ATP production rates (2

37 urrents activate at unprecedentedly negative membrane potentials (-60 mV) even in the absence of intr

38 ncentrations of drug decreased mitochondrial membrane potential, a phenotype that was stably altered

39 de of tonic current generated at depolarized membrane potential-a property associated with outward re

40 odeling deficits and decreased mitochondrial membrane potential; a subset had increased resting mitoc

41 ase and H(+)/Na(+)/K(+)-dependent changes of membrane potential across the perimeter membrane.

42 epolarization conducts to SMCs, depolarizing membrane potential, activating L-type Ca(2+) channels an

43 f voltage-gated Ca(2+) channels near resting membrane potentials, activation of NMDA receptors in the

44 chemical probes that regulate mitochondrial membrane potential, adenosine 5'-triphosphate contents,

45 like manner to MB, can restore mitochondrial membrane potential after depolarization with rotenone.

46 The resulting short-term memory of the membrane potential allows to generate persistent firing

47 etically favourable in TbAQP2, driven by the membrane potential, although aquaporins are normally str

48 ncreased Ca(2+) influx closer to the resting membrane potential, an effect recapitulated by Abeta(1-4

49 ase (NKA) complex is the master regulator of membrane potential and a target for anti-cancer therapie

50 lasma membrane permeability, reduced resting membrane potential and accelerated protein catabolism.

51 AMD1 depletion induced loss of mitochondrial membrane potential and accumulation of reactive oxygen s

52 not significant, differences in the resting membrane potential and action potential characteristics

53 ctural rearrangements, loss of mitochondrial membrane potential and activation of mitophagy.

54 n velocity primarily by altering the resting membrane potential and are associated with significant m

55 complex I that does not alter mitochondrial membrane potential and bioenergetics.

56 ative strategy that merges ultrafast optical membrane potential and Ca(2+) measurements, pharmacologi

57 ent DNA nanodevice that reports the absolute membrane potential and can be targeted to organelles in

58 Membrane potential and contractile activity was partiall

59 nd leading to a strong depolarization of the membrane potential and decrease of ATP levels.

60 AG hyperpolarized the membrane potential and decreased cytoplasmic calcium con

61 ncy, together with compromised mitochondrial membrane potential and elevated oxidative stress, result

62 loop that restrains the excitatory effect on membrane potential and firing activity evoked by NMDAR a

63 athy, restored cardiac myocyte mitochondrial membrane potential and flavoprotein oxidation, and preve

64 was assessed as alterations in mitochondrial membrane potential and flavoprotein oxidation.

65 progressively shorter, and the mitochondrial membrane potential and glucose uptake become progressive

66 The influence of AG on membrane potential and GSIS could only be averted in the

67 t1a KO hepatocytes had reduced mitochondrial membrane potential and higher mitochondrial reactive oxy

68 PPAR-gamma partially restored mitochondrial membrane potential and IFN-gamma production.

69 hNs, which likely led to depolarized resting membrane potential and increased spontaneous firing.

70 ive stress, yet exhibited high mitochondrial membrane potential and increased superoxide generation i

71 1 (TRPV1) on sensory neurons to alter their membrane potential and induce pain.

72 sed a transient depolarization of the plasma membrane potential and induced an imbalance of intracell

73 Cell membrane potential and inorganic ion distributions are c

74 f this current and contribute to the resting membrane potential and intrinsic properties of developin

75 n, synaptic vesicle transport, regulation of membrane potential and lipid biosynthesis increased.

76 pulse source triggers the increase of plasma membrane potential and membrane permeability.

77 but positively correlated with mitochondrial membrane potential and motility.

78 NA, and a similar reduction in mitochondrial membrane potential and NDUFA9 protein abundance.

79 tive protein channels for optical control of membrane potential and of ion homeostasis.

80 e worms significantly improved mitochondrial membrane potential and oxidative stress, with correspond

81 hondrial function, as reflected in decreased membrane potential and oxygen consumption.

82 ransport chain from NADH to O(2) generates a membrane potential and pH gradient of protons that can e

83 ion and impaired regulation of mitochondrial membrane potential and quality.

84 g cancer mouse model had lower mitochondrial membrane potential and reduced mitochondrial functionali

85 y play a crucial role in setting the resting membrane potential and regulating cellular excitability.

86 lycolysis is required to maintain the plasma membrane potential and that plasma membrane depolarizati

87 channels controlling the myometrial resting membrane potential and the mechanism of transition to a

88 ky integrator, where the input signal is the membrane potential and the output is the occupancy of a

89 cient VSMCs exhibited more polarized resting membrane potentials and higher protein kinase B (Akt) ac

90 but are constitutively open at physiological membrane potentials and modulated by calmodulin (CaM) in

91 individual mitochondrion can have disparate membrane potentials and that interventions causing acute

92 ochondrial-encoded proteins, respiration and membrane potential, and an increase of reactive oxygen s

93 atory responses, redox charge, mitochondrial membrane potential, and electron leak, we found minimal

94 Mitochondrial biogenesis, membrane potential, and function were significantly redu

95 AMP-induced pores, depolarizes the bacterial membrane potential, and impairs membrane recovery.

96 en consumption, increased fission, decreased membrane potential, and increased expression of the mito

97 s iron metabolism, depolarizes mitochondrial membrane potential, and induces cell death specifically

98 PP was sufficient to reduce OXPHOS capacity, membrane potential, and promoted mitochondrial fission.

99 in ROS production, decrease of mitochondrial membrane potential, and proteasome activity modulation,

100 between inorganic ion distribution, resting membrane potential, and the DeltaG' of ATP hydrolysis: a

101 which differ in their morphology, mobility, membrane potential, and vicinity to other organelles.

102 th interferes with local ionic environments, membrane potentials, and transepithelial potentials, res

103 The 7G8 isoform transports CQ in a membrane potential- and pH-dependent manner, consistent

104 bioenergetics measurements and mitochondrial membrane potential- and redox-sensitive dyes are used to

105 lity grows as a smooth nonlinear function of membrane potential; and (2) a "population" framework, wh

106 o address these limitations, we use the cell membrane potential as a bioenergetic indicator of EET by

107 ar reactive oxygen species and mitochondrial membrane potential as well as microscopy (confocal laser

108 ptical method for observing rapid changes in membrane potential at temporal resolutions of ~25 ns.

109 variables such as respiration, mitochondrial membrane potential, buffer calcium, and substrate effect

110 -450a overexpression decreased mitochondrial membrane potential but increased glucose uptake and viab

111 t, in male myocytes, Kv2.1 channels regulate membrane potential but not Ca(V)1.2 channel clustering.

112 s with sex: in males, Kv2.1 channels control membrane potential but, in female myocytes, Kv2.1 plays

113 160 to -180 mV, reproducibly depolarized the membrane potential by 95 mV on average.

114 onal significance of regulation of dendritic membrane potential by the sodium-leak channel complex, a

115 calcium, prevented the loss of mitochondrial membrane potential (by 70%-80%), and resulted in a 40%-5

116 otential and to subthreshold fluctuations in membrane potential can also modulate excitability in imp

117 -of-the-art VoltageFluor-type dye respond to membrane potential changes in a similar manner to the pa

118 orophores enable the direct visualization of membrane potential changes in living systems.

119 Direct observation of rapid membrane potential changes is critical to understand how

120 d to kinetic data on cGMP activity and early membrane potential changes measured in bulk cell populat

121 The calcium deficit was related to resting membrane potential changes that led to abnormal inactiva

122 DIII and DIV voltage sensors in response to membrane potential changes.

123 ibition, synaptically driven fluctuations in membrane potential, changes in cellular conductance and

124 E/CFS CD8+ T cells had reduced mitochondrial membrane potential compared with those from healthy cont

125 dly adapting currents that did not depend on membrane potential, confirming that fast adaptation does

126 reverse-mode H(+) transport depended on the membrane potential, cytosolic P(i) concentration, and ma

127 ce of SCI (chronic depolarization of resting membrane potential) decrease sensitivity to opioid-media

128 l blocker nimodipine could hyperpolarize the membrane potential, decrease the spontaneous activity, a

129 g Delta9-THC showed a hyperpolarized resting membrane potential, decreased spontaneous firing rate, i

130 e dehydrogenase, Rhes disrupts mitochondrial membrane potential (DeltaPsi (m) ) and promotes excessiv

131 asuring O(2) consumption rates (OCR) and the membrane potential (Deltapsi(m) ).

132 Additionally, 1-6 disrupt mitochondrial membrane potential (DeltaPsi(m)) and induce oxidative st

133 Membrane potential (DeltaPsi(m)) was determined by fluor

134 ndrial ETC flux and adjust the mitochondrial membrane potential (DeltaPsi(m)), to minimize reactive o

135 stribution is also governed by mitochondrial membrane potential (DeltaPsi(m)).

136 r the generation and maintenance of a normal membrane potential (DeltaPsi) across the inner mitochond

137 nels in the thylakoid membrane dissipate the membrane potential (Deltapsi) component to allow for a h

138 (ITC) results, we propose that the bacterial membrane potential (Deltapsi) is possibly an underestima

139 We recently reported that membrane potential (DeltaPsi) primarily determines the r

140 H 5.0 to 9.0 in the absence or presence of a membrane potential (DeltaPsi, interior positive), and th

141 Under these conditions, the membrane potential, Deltapsi, is maintained at a lower t

142 ssment indicated reduced inner mitochondrial membrane potential (DeltaPsim) and metabolic plasticity

143 Mitochondrial membrane potential (DeltaPsim) is a global indicator of

144 hondrial pH, redox states, and mitochondrial membrane potential (DeltaPsiM).

145 ess dependent on Tim23 than on mitochondrial membrane potential (DeltaPsim).

146 vascular smooth muscle cells through plasma membrane potential-dependent coupling with PTEN.

147 a; either possessing a previously undetected membrane potential-dependent firing or regular firing ph

148 back to NADPH by activation of mitochondrial membrane potential-dependent nicotinamide nucleotide tra

149 al defects including collapsed mitochondrial membrane potential, dissipated ATP production, and eleva

150 at S phase, depolarization of mitochondrial membrane potential, down-regulation of Bcl-2 expression

151 Membrane potential drives uptake of the principal excita

152 ugh their preference for certain patterns of membrane potential due to their intrinsic properties.

153 ells, which can generate large transients in membrane potential during the propagation of action pote

154 These discoveries argue that bacterial membrane potential dynamics deserve more attention.

155 will deepen our understanding of the role of membrane potential dynamics in the regulation of many bi

156 Here, by measuring membrane potential dynamics of Bacillus subtilis cells,

157 -electronics, including electronic assays of membrane potential dynamics, nano-electronic actuation o

158 s revealing the signaling roles of bacterial membrane potential dynamics.

159 In this study, we focused on the membrane-potential dynamics immediately following action

160 Membrane-potential dynamics mediate bacterial electrical

161 Therefore, electrically induced membrane-potential dynamics offer a reliable approach fo

162 drugs on epithelial TREK-1 currents, plasma membrane potential (Em), and intracellular Ca(2+) (iCa)

163 ross the membrane, contributing to the cross-membrane potential essential for a myriad of cellular ac

164 lysosomal membranes, where it establishes a membrane potential essential for lysosomal function and

165 uoles from Arabidopsis sense and control the membrane potential essentially via the K(+)-permeable TP

166 ounterbalanced by a high mitochondrial inner membrane potential, even under conditions of severe mito

167 ing the last three decades, the subthreshold membrane potential events that cause changes in dopamine

168 bining high-resolution optical recordings of membrane potential, exocytosis, and Ca(2+) in cultured h

169 in synaptic inputs activation, subthreshold membrane potential fluctuations, and output spike trains

170 rupture occurred after loss of mitochondrial membrane potential, followed by entry of bile, cell deat

171 , +100 mV depolarisation relative to resting membrane potential following 40 mV hyperpolarising prepu

172 A technology that simultaneously records membrane potential from multiple neurons in behaving ani

173 action causes a hyperpolarizing shift of the membrane potential from resting value, mediated by an in

174 ies subpopulations of neutrophils where cell-membrane potential functions as a rheostat to modulate t

175 Ca(2+) uptake is driven by the sizable inner-membrane potential generated by the electron-transport c

176 te that the distance-dependent mitochondrial membrane potential gradient exists in vivo in mice.

177 tain oxidative phosphorylation by creating a membrane potential gradient that is generated by the ele

178 Hv1 conformational dynamics under an applied membrane potential has been elusive.

179 ferent tissues with widely different resting membrane potentials has been shown to be equal to the Ne

180 Changes in cell metabolism and plasma membrane potential have been linked to shifts between ti

181 l potassium conductance, a more negative DCT membrane potential, higher expression of phosphorylated

182 cysteine deprivation leads to mitochondrial membrane potential hyperpolarization and lipid peroxide

183 transfer chain (ETC) mitigated mitochondrial membrane potential hyperpolarization, lipid peroxide acc

184 ptic depolarisation and irreversible loss of membrane potential in CA1 neurons from diseased animals

185 ptic depolarisation and irreversible loss of membrane potential in CA1 neurons from diseased animals

186 ptic depolarisation and irreversible loss of membrane potential in CA1 neurons from diseased animals

187 sites, suggesting a role of Purkinje neuron membrane potential in cerebellar learning.

188 depolarization without affecting the overall membrane potential in Drp1-knockout cells.

189 The cell resting membrane potential in each of 3 different tissues with w

190 led us to functionally profile mitochondrial membrane potential in live tumours.

191 ularity, as well as depolarizing the resting membrane potential in mHb ChNs in control-sleep mice.

192 , but was accompanied by depolarized resting membrane potential in mHb ChNs.

193 ochondrial redox state and the mitochondrial membrane potential in mice of both sexes with geneticall

194 The role of membrane potential in most intracellular organelles rema

195 Here we measure mitochondrial membrane potential in non-small-cell lung cancer in vivo

196 harmaceutical agents decreased mitochondrial membrane potential in porcine fetal fibroblasts, the num

197 These findings highlight the importance of membrane potential in regulating cell physiology and gro

198 al utility as optogenetic tools for altering membrane potential in target cells.

199 nd alleviated the depletion of mitochondrial membrane potential in vitro.

200 At the same time, mitochondrial mass and membrane potential increase.

201 ion of UQCRH in KMRC2 restored mitochondrial membrane potential, increased oxygen consumption, and at

202 r rate of O(2) uptake, loss of mitochondrial membrane potential, increased reactive oxygen species (R

203 ating channel opening at more hyperpolarized membrane potentials, indicating gain of function.

204 Using a fluorescent membrane potential indicator during in vivo single-cell-

205 rove that light driven perturbations of cell membrane potential induce homeostatic reactions and modu

206 m by which they transform an electrochemical membrane potential into biologically useful chemical ene

207 on channel activation in mammalian cells and membrane potential is an early indicator of control of t

208 ed this view, and we now know that bacterial membrane potential is dynamic and plays signaling roles

209 We show that when the membrane potential is hyperpolarized with respect to the

210 e capacity of this H(+) pump to recharge the membrane potential is rooted in its voltage- and pH-depe

211 xpand our understanding of how modulation of membrane potential is used as a mechanism of development

212 The resting membrane potential is viewed as a diffusion potential.

213 monium ions, we suggest this may explain the membrane potential lability.

214 ttenuates OXPHOS and collapses mitochondrial membrane potential leading to cell death or senescence.

215 reveals that reduction in the mitochondrial membrane potential leads to significant decreases in bot

216 erapeutics sensitized cells to mitochondrial membrane potential loss and apoptosis.

217 anges in mitochondrial activity with reduced membrane potential, low ATP production, and high lactate

218 d to endosomal trafficking and mitochondrial membrane potential maintenance.

219 In order to understand how the axonal membrane potential may show temperature dependence, we h

220 mesenteric vessels using wire myography and membrane potential measurements.

221 Mathematical formulations of mitochondrial membrane potential, mitochondrial Ca(2+) cycling, mitoch

222 We show that mitochondrial membrane potential (MMP) can be used to prospectively is

223 encing (RNA-seq), we show that mitochondrial membrane potential (MMP) distinguishes quiescent from cy

224 We thus highlight membrane potential modulation as a tractable tool for mo

225 Numerical simulation suggests a change in membrane potential of - 15-20 mV mimics altering tempera

226 found that NPY signaling hyperpolarized the membrane potential of a subset of excitatory IC neurons

227 The resting membrane potential of aging type I neurons in the NOD, A

228 a(2+) transient firing regulated the resting membrane potential of colonic tissues as a specific Ano1

229 segments of mitochondria and can rescue the membrane potential of damaged mitochondria by ER-associa

230 Using Voltair, we could measure the membrane potential of different organelles in situ in li

231 cellular potassium concentration affects the membrane potential of neurons, and, thus, neuronal activ

232 Here, we monitor mitochondrial membrane potential of single lymphocytic leukemia cells

233 n voltage-dependent K(+) currents or resting membrane potential of UBSM cells, suggesting that these

234 r in obesity and suggest that hyperpolarized membrane potential of, and potentiated inhibitory inputs

235 sodium conductance that controls the resting membrane potentials of neurons.

236 No major changes in membrane potential or adenosine 5'-triphosphate (ATP) co

237 d with intercellular heterogeneity of plasma membrane potential or the phases of the cell cycle.

238 t on orchestrated fluctuations in the plasma membrane potential or voltage, which are mediated via th

239 as the depolarization and repolarization of membrane potentials or large ion shifts.

240 for maintaining highly stereotyped infraslow membrane potential oscillations of dopamine ARC neurons.

241 e of lactation, TIDA neurons shift to faster membrane potential oscillations, a reconfiguration that

242 entation of neuron and field to estimate the membrane potential perturbation in pyramidal cells.

243 an important role in regulating cell volume, membrane potential, pH, secretion, and the reversal pote

244 uitinates proteins on mitochondria that lost membrane potential, promoting the elimination of damaged

245 K(2P) channels regulate the resting membrane potential, providing background K(+) currents c

246 radiol reduced both potassium current in the membrane potential range typically achieved during respo

247 ride and thereby neuronal parameters such as membrane potential rather than acting as a presynaptic g

248 erturbations in mitochondrial morphology and membrane potential, reduced ATP production, and increase

249 es (ROS) activities, increased mitochondrial membrane potential, reduced calcium levels, and also hig

250 tronics and enhance our understanding of how membrane potential regulates organelle biology.

251 e mitochondria decreased mitochondrial mass, membrane potential, respiration, and electron transport

252 increases synaptic activity that depolarizes membrane potential responses at the behaviorally relevan

253 We measured the membrane potential responses of individual neurons in th

254 tivity and chronic depolarization of resting membrane potential (RMP) that is maintained by cAMP sign

255 To encode light-dependent changes in membrane potential, rod and cone photoreceptors utilize

256 We identified a repertoire of subthreshold membrane potential signatures associated with distinct i

257 ical and non-canonical Wnt pathways regulate membrane potential signifying a very early event in the

258 iently alleviated when comparable changes in membrane potential simultaneously occur in each of the c

259 observed experimentally in the absence of a membrane potential stimulus (0 mV).

260 electrochemical reactor, we demonstrate that membrane potential strongly correlates with EET.

261 rmore, mutant pollen tubes had less negative membrane potentials, substantiating a mechanistic role f

262 a stable protein which impacts mitochondrial membrane potential, suggesting a potential third coding

263 reveal a primary functional role for resting membrane potential taking place within the first 3 h aft

264 +)/NADH is caused by increased mitochondrial membrane potential that impairs mitochondrial electron t

265 rods lacking CNG channels exhibit a resting membrane potential that was ~10 mV hyperpolarized compar

266 In response to a depolarizing membrane potential, the S4 helix undergoes an outward di

267 ibutes to setting the hair cell and afferent membrane potentials; the potassium efflux from type I ha

268 er conduction by hyperpolarizing the resting membrane potential, thereby increasing Na(+) channel ava

269 n potential threshold and a more depolarized membrane potential, thus reducing membrane excitability.

270 ow electrical currents underlying changes in membrane potential to leak to 'coupled' partners, dampen

271 espiratory complexes, these cells generate a membrane potential to support uptake of calcium into the

272 introduce basic biophysical theories of the membrane potential to the microbiology community and dis

273 and phospholipid membranes in the absence of membrane potential, toxins that bind VSD and modulate th

274 riguing connection between ribosomes and the membrane potential, two fundamental properties of cells.

275 s hyperpolarized with respect to the resting membrane potential, type-1 metabotropic glutamate recept

276 propose maintains intermediate mitochondrial membrane potentials under physiologic conditions, thus m

277 ll patch clamp experiments and assessment of membrane potential using the slow voltage-sensitive dye

278 We used membrane potential (V (m)) and Ca(2+) imaging to investi

279 ensitive dye (VSD) imaging, which visualizes membrane potential variations in the CN and its branches

280 uscle cells, ChRs can be used to control the membrane potential via illumination.

281 differences in the regulation of neutrophil membrane potential via KCa3.1.

282 Mitochondrial membrane potential was assessed with JC-1 staining.

283 tained locomotion periods, cortical neuronal membrane potential was at its most depolarized and least

284 e TSPAN-7 KD also enhanced Ca(2+) entry when membrane potential was clamped with depolarization, the

285 y by increasing ATP levels and mitochondrial membrane potential was confirmed.

286 Surprisingly, a high mitochondrial inner membrane potential was maintained in MitoPark SNc DaNs.

287 try, Western blotting, and patch clamping of membrane potentials was performed to evaluate the molecu

288 tly, mitochondrial ETC enzyme activities and membrane potential were lowered in the CIH group.

289 chain (ETC) complex I, IV, V activities, and membrane potential were performed in the ventrolateral m

290 The role of calcium alteration and membrane potential were revealed using Fluo-4 AM and tet

291 a-CEL16&28 had depolarized the mitochondrial membrane potential, whereas Abeta-CEL16 had increased mi

292 ry electron transfer and establishing strong membrane potential, which is key to biofilm matrix produ

293 ells, the NKA generates the negative resting membrane potential, which is the basis for almost all as

294 properties, including depolarization of the membrane potential while simultaneously decreasing actio

295 imals maintained a more normal mitochondrial membrane potential while those isolated from untreated a

296 vo Furthermore, we show that dissipating the membrane potential with an ionophore decreases the preva

297 itative model to associate the mitochondrial membrane potential with the key pharmacokinetic paramete

298 is unaffected by collapsing the mitochondria membrane potential with the uncoupler carbonyl cyanide m

299 eration, and a 50% decrease in mitochondrial membrane potentials with respect to equivalent concentra

300 oxidative stress and decreased mitochondrial membrane potential, with higher mtDNA release in brain a