ライフサイエンスコーパス: membrane ruffling

1 y of surface ORAI1 and increasing the plasma membrane ruffling.

2 supports a functional link between SOCE and membrane ruffling.

3 ated Rac3 causes transformation and leads to membrane ruffling.

4 KIalpha in PDGF-stimulated cells resulted in membrane ruffling.

5 ways that stimulate actin reorganization and membrane ruffling.

6 actin dynamics, lamellipodia protrusion, and membrane ruffling.

7 nosomes but, surprisingly, did not eliminate membrane ruffling.

8 t-Leu-Phe to induce actin reorganization and membrane ruffling.

9 itic cells but may be required downstream of membrane ruffling.

10 ession systems, also inhibited GH-stimulated membrane ruffling.

11 The small GTPase Rac mediates membrane ruffling.

12 luencing actin cytoskeletal organization and membrane ruffling.

13 from the cytosol to the plasma membrane, and membrane ruffling.

14 esponse to stimuli (e.g., serum) that induce membrane ruffling.

15 m pathways such as PAK, JNK/SAPK kinases and membrane ruffling.

16 as a dominant negative for another pathway, membrane ruffling.

17 effect on the ability of RasVal-12 to induce membrane ruffling.

18 Shc mutant, has no effect on IGF-I-mediated membrane ruffling.

19 resembles the time course of IGF-I-mediated membrane ruffling.

20 ncident with increases in cell spreading and membrane ruffling.

21 wortmannin and LY294002 blocks IGF-I-induced membrane ruffling.

22 ined actin stress fibers and showed enhanced membrane ruffling.

23 mplex may regulate growth cone extension and membrane ruffling.

24 inct pathway that regulates adhesion-induced membrane ruffling.

25 ab5-dependent pinocytosis and Rac1-dependent membrane ruffling.

26 ffect of Ha-Ras(G12V) on pinocytosis but not membrane ruffling.

27 of PDGF-induced mitogenesis, chemotaxis, and membrane ruffling.

28 5-P3) also produced actin reorganization and membrane ruffling.

29 yphimurium strains are unable to induce this membrane ruffling.

30 d mutant of Ras, V12Ras, in the induction of membrane ruffling.

31 ynthesis, but retained the ability to induce membrane ruffling.

32 lar fluid and solutes through dynamic plasma membrane ruffling.

33 reased pHi and single cell behaviors such as membrane ruffling.

34 ion of KCNQ2/3 channel currents, and loss of membrane ruffling.

35 ttenuating actin polymerization and reducing membrane ruffling.

36 ytoskeletal organization, and reduced plasma membrane ruffling.

37 s of active GTP-bound Rac and EGF-stimulated membrane ruffling.

38 K3 prevents the formation of CrkII-dependent membrane ruffling.

39 enhanced superoxide production and increased membrane ruffling.

40 is most evident in podosomes and regions of membrane ruffling.

41 associated with enhanced cell spreading and membrane ruffling.

42 ells has no additive effect on the amount of membrane ruffling.

43 o promote cell survival, transformation, and membrane ruffling.

44 ion of p50alpha also restored PDGF-dependent membrane ruffling.

45 membrane trafficking, glucose transport, and membrane ruffling.

46 /- p85beta-/-) are defective in PDGF-induced membrane ruffling.

47 gulators of endocytosis, actin dynamics, and membrane ruffling.

48 spholipase D (PLD) homolog, which facilitate membrane ruffling.

49 ium stimulates signaling pathways leading to membrane ruffling, actin cytoskeleton rearrangements, an

50 of PIPKI-alpha causes pronounced defects in membrane ruffling, actin organization, and focal adhesio

51 s a mitogen, cAMP-elevating agents stimulate membrane ruffling, Akt phosphorylation, and p70 ribosoma

52 Rac1 effector binding loop shown to abolish membrane ruffling also abolishes interaction with POR1.

53 d -independent growth assays, cell cycle and membrane ruffling analyses showed that Akt exerts estrog

54 Eklf-deficient EryP exhibit membrane ruffling and a failure to acquire the typical d

55 hat schwannoma-derived Schwann cells exhibit membrane ruffling and aberrant cell spreading when plate

56 e degranulation and is impaired in mediating membrane ruffling and actin assembly.

57 wild-type L. pneumophila, without affecting membrane ruffling and actin polymerization.

58 rin and phosphotyrosine, along with enhanced membrane ruffling and actin stress fiber formation.

59 oteins Rho and Rac have a regulatory role in membrane ruffling and activated Rho has been shown to st

60 These results indicate that membrane ruffling and activation of MAP kinase represent

61 Protein kinase C (PKC) stimulates membrane ruffling and adhesion [2], but the mechanism by

62 athways and the actin cytoskeleton to induce membrane ruffling and bacterial internalization.

63 that MARCKS and PKC regulate actin-dependent membrane ruffling and cell adhesion, perhaps via a PIP2-

64 These data show that SHEP1 regulates membrane ruffling and cell migration and that binding to

65 221F fails to induce JNK and PAK activation, membrane ruffling and cell migration, suggesting that it

66 ed to function downstream of Arf6 to control membrane ruffling and cell migration, this pathway has n

67 tly, inhibition of Hsp90 activity suppressed membrane ruffling and cell migration, while expression o

68 of interacting with Crk inhibits Bmx-induced membrane ruffling and cell migration.

69 mediates attachment-induced JNK activation, membrane ruffling and cell motility in a Rac-dependent m

70 tion of 14-3-3zeta to increase AngII-induced membrane ruffling and cell motility.

71 th hormone-dependent actin reorganization in membrane ruffling and cell motility.

72 ependent of Rac1 activation, actin-dependent membrane ruffling and cell spreading are Rac1-dependent

73 R-induced Rac1 activation and Rac1-dependent membrane ruffling and cell spreading were restored.

74 This mmLDL activates macrophages inducing membrane ruffling and cell spreading, activation of ERK1

75 anism by which Neisseria gonorrhoeae elicits membrane ruffling and cellular invasion of the cervical

76 ed actin remodeling manifested by peripheral membrane ruffling and circular dorsal ruffles (CDRs).

77 onococcal PLD may be necessary to potentiate membrane ruffling and clustering of gonococci on the cer

78 s engaged with extracellular matrix, whereas membrane ruffling and decreased actin stress fibers indu

79 ever, such signaling when persistent induced membrane ruffling and decreased cell motility.

80 s in the actin-binding domain cause aberrant membrane ruffling and defective actin stress fibre forma

81 ed cytoskeletal rearrangements manifested by membrane ruffling and disruption of intercellular juncti

82 f PIP(2) and produced smooth T cells void of membrane ruffling and filopodia.

83 ress fibers and exhibit clear differences in membrane ruffling and filopodial extension when stained

84 A cells and assayed for GH- and PDGF-induced membrane ruffling and fluid phase pinocytosis.

85 ed PAK1 have been reported to either promote membrane ruffling and focal adhesion assembly or cause f

86 with multiple cellular responses, including membrane ruffling and focal complex formation.

87 C, and N43D) retained the ability to promote membrane ruffling and focus formation.

88 beta but not Nckalpha blocks PDGF-stimulated membrane ruffling and formation of lamellipoda.

89 eta but not Nckalpha blocks Rac1-L62-induced membrane ruffling and formation of lamellipodia, suggest

90 ment caused shape changes in the cells, with membrane ruffling and formation/retraction of thin actin

91 ssion of Bmx with Cas results in an enhanced membrane ruffling and haptotactic cell migration.

92 V), an activated Ras mutant, stimulated both membrane ruffling and horseradish peroxidase uptake.

93 erexpression of MAYP decreased CSF-1-induced membrane ruffling and increased filopodia formation, mot

94 MAP kinase, was defective for stimulation of membrane ruffling and induction of DNA synthesis.

95 arrangements encompass increased Rac-induced membrane ruffling and lamellipodia, Cdc42-initiated filo

96 cretion system (T3SS), leading to pronounced membrane ruffling and macropinocytic uptake of attached

97 ity is initially manifested by inhibition of membrane ruffling and macropinocytosis in infected macro

98 or of the actin remodeling events that drive membrane ruffling and macropinocytosis.

99 RAC1, a prerequisite for the stimulation of membrane ruffling and macropinocytosis.

100 ica bead uptake in a process associated with membrane ruffling and macropinocytosis.

101 y showed altered actin assembly evidenced by membrane ruffling and macropinosomes.

102 ulate PAK and JNK activity but still induced membrane ruffling and mediated transformation.

103 mulation of two distinct insulin bioeffects, membrane ruffling and mitogenesis, in 3T3-L1 adipocytes

104 -assisted laser inactivation) blocked plasma-membrane ruffling and motility of Fos-transformed fibrob

105 mation in CV1 cells and blocked PDGF-induced membrane ruffling and nucleated actin assembly.

106 triking morphological alterations, including membrane ruffling and numerous pseudopodial protrusions,

107 d areas 5-7-fold greater than NHSC, aberrant membrane ruffling and numerous, frequently disorganized

108 sion under these conditions causes extensive membrane ruffling and overrides the block in membrane fu

109 Arf6 and its GEFs facilitated membrane ruffling and pathogen invasion via ARNO, and tr

110 coupled events, our study demonstrates that membrane ruffling and pinocytosis are regulated by disti

111 h lacking a functional SH2 domain, inhibited membrane ruffling and pinocytosis induced by GH and PDGF

112 g three Rac-dependent readouts: induction of membrane ruffling and pinocytosis, stimulation of cell m

113 Activation of Ras stimulates cell surface membrane ruffling and pinocytosis.

114 AYP is a negative regulator of CSF-1-induced membrane ruffling and positively regulates formation of

115 tween the intracellular pathways that induce membrane ruffling and promote cell survival.

116 to wounding was characterized by (1) plasma membrane ruffling and protrusion into the wound, (2) lam

117 Membrane ruffling and pseudopod extension via the BLTR w

118 monella typhimurium into host cells requires membrane ruffling and rearrangement of the actin cytoske

119 Rac allele was able to rescue the defect in membrane ruffling and restore the localization of a fluo

120 Membrane ruffling and reversible cell-substratum interac

121 Rac1 and RhoA regulate membrane ruffling and stress fiber formation.

122 ts estrogen-like activity on cell growth and membrane ruffling and that a selective ErbB2 inhibitor,

123 aldesmon may be a key protein that modulates membrane ruffling and that this may involve changes in c

124 cation to the membrane, which in turn causes membrane ruffling and the formation of cellular protrusi

125 Our experiments show that activation of membrane ruffling and transcriptional activation of c-ju

126 to the transcription factor c-Jun and cause membrane ruffling and transformation, indicating that sw

127 JNK activation but was defective in inducing membrane ruffling and transformation.

128 infected cells with 2-10 muM P27 caused cell membrane ruffling and uptake of virus and polymerized fo

129 ine, and filamentous actin filament into the membrane rufflings and uropods of human neutrophils.

130 reatment with GGTIs led to the inhibition of membrane-ruffling and transforming activities of both ac

131 SHEP1 unable to promote Cas-Crk association, membrane ruffling, and cell migration toward epidermal g

132 Gas6 stimulated lamellipodial extension, membrane ruffling, and chemotaxis of immortalized NLT Gn

133 was rapid, involved extensive cholangiocyte membrane ruffling, and culminated in parasite penetratio

134 d GLUT4 translocation, growth factor-induced membrane ruffling, and DNA synthesis, indicating that Pt

135 esion to fibronectin, secretory enhancement, membrane ruffling, and filamentous actin assembly.

136 plasma membrane and stimulates GTP loading, membrane ruffling, and filopodia formation.

137 is required for growth hormone (GH)-induced membrane ruffling, and increases mitogenesis stimulated

138 olocalization with cortical actin filaments, membrane ruffling, and lamellipodia formation, compared

139 luence growth factor-mediated proliferation, membrane ruffling, and migration.

140 o1c promoted G-actin accumulation and plasma membrane ruffling, and Myo1c knockdown confirmed its con

141 FO showed hepatocyte autophagosomes, nuclear membrane ruffling, and porphyrin-containing vacuoles wit

142 otilities, including surveillance movements, membrane ruffling, and process extension or retraction.

143 eas Rac regulates lamellipodia formation and membrane ruffling, and RhoA regulates the formation of s

144 vated by MLCK at the cell periphery controls membrane ruffling, and that the spatial regulation of ML

145 threonine kinase, to induce lamellipodia and membrane ruffling, and to activate the c-Jun NH2-termina

146 mice failed to become polarized, to undergo membrane ruffling, and to migrate in response to chemoki

147 k results in localized actin polymerization, membrane ruffling, and, ultimately, pathogen entry.

148 Pinocytosis and membrane ruffling are among the earliest and most dramat

149 e is provided that actin-myosin assembly and membrane ruffling are regulated by distinct signaling pa

150 abnormal proliferation, cell morphology, and membrane ruffling are suppressed by the TRQQKRP motif de

151 n (CTTN), a regulator of the cytoskeleton at membrane ruffling areas.

152 In fibroblasts PAK1 localizes to areas of membrane ruffling, as well as to amiloride-sensitive pin

153 d MLC phosphorylation and blocked peripheral membrane ruffling, as well as turnover of focal adhesion

154 Knockdown of RalA or Sec5 results in reduced membrane ruffling at sites of attachment and impairs bac

155 oad lamellipodium, a response accompanied by membrane ruffling at the cell margin.

156 ese results demonstrated that SOCE regulates membrane ruffling at the leading edge of cells.

157 ccumulation of the PI(4,5)P(2) biosensor and membrane ruffling at the opposite side of the cells.

158 activated Ras(V12) mutant induces prominent membrane ruffling, branching morphogenesis on three-dime

159 d and platelet-derived growth factor-induced membrane ruffling but not Bradykinin-induced filopodia f

160 king Tyr-439 and Tyr-494 inhibits GH-induced membrane ruffling but still activates JAK2.

161 ealed that the DN construct had no effect on membrane ruffling, but dramatically inhibited stress fib

162 In contrast, membrane ruffling, but not cell contraction, requires Ra

163 POR1, a Rac1-interacting protein involved in membrane ruffling, but not with the dominant-negative mu

164 take by 36%, GLUT4 translocation by 35%, and membrane ruffling by 50%, all of which are phosphatidyli

165 Dominant-negative Akt inhibited membrane ruffling by 54%; however, R25C-Akt did not have

166 ed versions of POR1 inhibit the induction of membrane ruffling by an activated mutant of Rac1, V12Rac

167 rowth factors stimulate actin remodeling and membrane ruffling by integration of signaling pathways t

168 tor (PDGF)-induced chemotaxis was to promote membrane ruffling by regulating phosphatidylinositol 3,4

169 role of STIM1 and ORAI1 in the promotion of membrane ruffling by showing that phospho-STIM1 localize

170 ation during ruffling, and the inhibition of membrane ruffling by the Ca(2+)-channel inhibitor SKF963

171 sulted in distinct linear or circular/dorsal membrane ruffling, c-Abl-null cells demonstrated dramati

172 Since Rac-dependent membrane ruffling can be stimulated by PI 3-kinase, it a

173 Lamellipodia formation and membrane ruffling caused by active PAK1 expression, howe

174 ator of diverse cellular functions including membrane ruffling, cell cycle progression, and transform

175 to sustain Rac1 signalling, trigger optimal membrane ruffling, cell migration and invasion.

176 cell spreading, lamellipodia formation, and membrane ruffling, cell morphologies generated by active

177 R), which also induces actin reorganization, membrane ruffling, cell spreading, polarization, and mig

178 t of PI3K, local PI(3,4,5)P(3) synthesis and membrane ruffling could be induced, with corresponding l

179 s typical of FCepsilonRI signaling including membrane ruffling, cytoskeletal rearrangements, and, in

180 roduction of p85alpha or p85beta rescues the membrane ruffling defect.

181 little effect on the rate and morphology of membrane ruffling, demonstrating that early production o

182 e, we suggest a role of N-WASP in regulating membrane ruffling downstream of phosphatidylinositol 4,5

183 ium that are incapable of inducing host cell membrane ruffling fail to induce apoptosis.

184 This was associated with decreased membrane ruffling, failure to establish cell polarity, a

185 changes in actin-dependent processes such as membrane ruffling, filopodial protrusion, and cell motil

186 e (ERK) activation and the other controlling membrane ruffling formation.

187 a striking increase in spontaneous motility, membrane ruffling, formation of long actin extensions (f

188 Consistent with membrane ruffling, gonococci were found residing within

189 nduced actin cytoskeleton reorganization and membrane ruffling in 3T3-L1 fibroblasts and Rat1 cells t

190 ted transmits signals leading to actin-based membrane ruffling in fibroblasts.

191 R/IR or the CSF1R/IRDelta960 rapidly induced membrane ruffling in Rat1 fibroblasts.

192 and Rhotekin leads to loss of Rho-dependent membrane ruffling in response to epidermal growth factor

193 ther increased pHi is a sufficient driver of membrane ruffling in single cells.

194 T4 translocation, c-fos expression, and cell membrane ruffling in single-cell microinjection assay.

195 of the constitutively active RacV12 induces membrane ruffling, increases PI4KIIbeta translocation to

196 , we show that SCH 51344 specifically blocks membrane ruffling induced by activated forms of H-RAS, K

197 ve mutants of SH2-Bbeta are shown to inhibit membrane ruffling induced by constitutively active Rac.

198 an insulin receptor (HIRc-B), SHIP inhibited membrane ruffling induced by insulin and IGF-I by 76 +/-

199 contrast, there was no significant change in membrane ruffling induced by PMA in the cells expressing

200 and size of actin stress fibers and inhibits membrane ruffling induced by Rac.

201 fails to induce ruffling but potently blocks membrane ruffling induced by serum or PDGF.

202 t the tip of the extending growth cone where membrane ruffling is most active.

203 lone A cells inhibited alpha6beta4-dependent membrane ruffling, lamellae formation, and migration.

204 mber of the Rho-family GTPases that promotes membrane ruffling, leading edge extension, and cell spre

205 co-opt the host actin cytoskeleton to induce membrane ruffling, leading to the uptake of the bacteriu

206 ll as cell polarity, lamellipodial assembly, membrane ruffling, macropinocytosis, and collective cell

207 amma receptor- mediated phagocytosis and for membrane ruffling mediated by structurally distinct rece

208 SV12, where V12 indicates valine-12) induces membrane ruffling, mitogen-activated protein (MAP) kinas

209 GFR) to mediate biological processes such as membrane ruffling, mitogenesis, and chemotaxis.

210 Furthermore, Myo1c-induced membrane ruffling of 3T3-L1 adipocytes is also compromis

211 ion, ghrelin led to actin polymerization and membrane ruffling on cells, with the specific co-localiz

212 Although Trk and EGFR each stimulate membrane ruffling, only Trk undergoes both selective and

213 LPS did not induce membrane ruffling or macropinocytosis in enterocytes, ex

214 differ from Rac1 in its ability to stimulate membrane ruffling or to interact with SmgGDS and IQGAP1-

215 ce of granule swelling and fusion, increased membrane ruffling, or exocytosis upon Ag challenge.

216 a on Ser(2152) is required for Pak1-mediated membrane ruffling, our results suggest a novel role for

217 y is dispensable for GBP2 recruitment and PV membrane ruffling; parasites can replicate, egress and s

218 H 51344 inhibits a critical component of the membrane ruffling pathway downstream from RAC and sugges

219 ersely, increasing cytosolic Ca(2+) enhances membrane ruffling, PI3K activity, and F-actin accumulati

220 ased pHi in single cells can drive localized membrane ruffling responses within seconds and increased

221 Kit-mediated filamentous actin assembly and membrane ruffling, secretory enhancement and adhesion to

222 ation stimulated by bradykinin and in dorsal membrane ruffling stimulated by PDGF, whereas the Cdc42G

223 acts as a dominant negative mutant, blocked membrane ruffling, suggesting that PIPKIalpha and PIP2 p

224 he Raji-S1 cells but does inhibit the active membrane ruffling that is necessary for cell polarizatio

225 ing that ARF6 regulates a pathway leading to membrane ruffling that occurs after the activation and m

226 Membrane ruffling then becomes polarized, leading to an

227 Active TRAF4 initiated robust membrane ruffling through Rac1, PAK1, and the oxidase, w

228 Rho function from stress fiber formation to membrane ruffling to confer an invasive phenotype.

229 monella virulence effectors elicit host cell membrane ruffling to facilitate pathogen invasion.

230 Salmonella species trigger host membrane ruffling to force their internalization into no

231 nduces actin cytoskeleton rearrangements and membrane ruffling to gain access into nonphagocytic cell

232 ase Rac1, established its ability to promote membrane ruffling, transformation, and activation of c-j

233 for their roles in actin rearrangements and membrane ruffling, translocated effectors also affect ho

234 Both PS and anti-PSR antibodies stimulated membrane ruffling, vesicle formation, and "bystander" up

235 Ras controls membrane ruffling via the small GTPase Rac.

236 Ha-Ras(G12V)-stimulated pinocytosis but not membrane ruffling was abolished by either wortmannin or

237 or-induced cytoskeletal rearrangement, i.e., membrane ruffling, was significantly inhibited (78 +/- 1

238 n and platelet-derived growth factor-induced membrane ruffling, we investigated whether NIH 3T3 cells

239 tial adhesion to fibronectin also stimulates membrane ruffling; we show that this ruffling is indepen

240 domain induce formation of lamellipodia and membrane ruffling, when transiently expressed in fibrobl

241 RhoGAP is rapidly translocated to regions of membrane ruffling, where it colocalizes with polymerized

242 Stimulation through L-selectin induced membrane ruffling, whereas PAF or IL-8 induced bipolar s

243 broblasts induced lamellipodia formation and membrane ruffling, which was unrelated to the substrate

244 r purine doses caused process retraction and membrane ruffling, which were blocked by joint applicati

245 actin polymerization-dependent spreading and membrane ruffling while Rac1-independent BCR capping rem

246 asion-deficient mutant (achieved by inducing membrane ruffling with epidermal growth factor) induced

247 ector, resulted in a dramatic stimulation of membrane ruffling without affecting the uptake of horser