ライフサイエンスコーパス: membrane-permeable

1 ted by subsequent addition of TPEN, which is membrane permeable.

2 perties of the peptides and making them more membrane permeable.

3 ferative effects, suggesting that hPL is not membrane-permeable.

4 the CA inhibitor, which is relatively slowly membrane-permeable.

5 182,780 but could be provoked using non-cell membrane-permeable 17beta-estradiol-BSA in all cells tes

6 We previously developed a class of membrane-permeable 2-aminoquinoline inhibitors and later

7 or stilbene disulfonate maleimide, SDSM) and membrane-permeable 7-diethylamino-3-(4'-maleimidyl)-4-me

8 vating intracellular cAMP levels with either membrane-permeable 8-Br-cAMP or an adenylyl cyclase acti

9 ergic agonist isoprenaline (1 microM) or the membrane-permeable 8-bromo-cAMP (2 mM) completely revers

10 Membrane-permeable 8-bromo-cAMP and the beta-adrenergic

11 Na2S enhanced CFTR stimulation by membrane-permeable 8Br-cAMP under inhibition of adenylyl

12 Jasplakinolide, a membrane-permeable actin-polymerizing and filament-stabi

13 n-1, 2-dioctanoylglycerol (DOG) were used as membrane permeable activators of protein kinases A (PKA)

14 mal fibroblasts, involving activation by the membrane-permeable adenosine analog 5-aminoimidazole-4-c

15 w that the antiproliferative effect of these membrane-permeable adenosine analogs is caused by transf

16 uncontrolled induction of PKA activity using membrane-permeable agonists is equally disruptive to gro

17 tamine-free cells was rescued with exogenous membrane-permeable alpha-ketoglutarate, but not pyruvate

18 active presynaptic terminals, we find that a membrane permeable analog of cAMP enhances the number of

19 eralgesia produced by 8-bromo-cAMP (a stable membrane permeable analog of cAMP) or by forskolin (an a

20 Here we show that microinjection of a membrane-permeable analog of cAMP in lumbar dorsal root

21 , and the peptide effect was unaffected by a membrane-permeable analog of cAMP.

22 by 1-oleoyl-1-acetyl-sn-glycerol (OAG), the membrane-permeable analog of diacylglycerol, were not de

23 : the effect was mimicked by 8-bromo-cGMP, a membrane-permeable analog, and by sodium nitroprusside,

24 In addition, a membrane-permeable analog, CPT-cAMP, also opened BK(Ca)

25 th atrial natriuretic peptide (ANP) and with membrane-permeable analogs of cGMP would induce a net ap

26 n MS/DB neurons were insensitive to the cAMP membrane permeable analogue 8-bromo-cAMP (1 mM), and app

27 ylate cyclase and dibutyryl cAMP (dbcAMP), a membrane permeable analogue of cAMP suppressed JAK3 expr

28 inhibitor, and mimicked by 8-Br-cGMP, a cell-membrane permeable analogue of cGMP.

29 2+ entry by oleoyl-2-acetyl-sn-glycerol, the membrane permeable analogue of the Galphaq-phospholipase

30 8Br-cGMP (100 microM), a membrane-permeable analogue of cGMP, evoked a robust act

31 , 100, and 500 microg or 2.5 mg 8-Br-cGMP, a membrane-permeable analogue of cGMP, or 1 and 100 microg

32 pment of chemical entities including various membrane-permeable analogues of cAMP and newly discovere

33 ects of nitric oxide donors were mimicked by membrane-permeable analogues of cGMP.

34 re, cellular studies revealed that 1 is cell membrane permeable and effectively inhibits intracellula

35 me, such as griselimycin and didemnin B, are membrane permeable and have intracellular targets.

36 r-soluble and, in many cases, were both more membrane permeable and more stable to liver microsomes t

37 identify candidate molecules that are highly membrane permeable and non-toxic at high concentrations.

38 nes are cyclized from head to tail, like the membrane permeable and orally bioavailable natural produ

39 cellent discrimination of photocleaved known membrane-permeable and -impermeable model library beads.

40 tion microscopy (SMLM), since these dyes are membrane-permeable and can be used alongside red (570-64

41 cal microscopy experiments show that RCS1 is membrane-permeable and can sense changes in the levels o

42 y experiments establish that Cu(II)[BOT1] is membrane-permeable and can successfully signal the prese

43 The sensor is membrane-permeable and easily transferable to measuremen

44 tively with another building block, which is membrane-permeable and free in solution, to form the dip

45 idues of the alpha-subunit was assessed with membrane-permeable and membrane-impermeable Cys-directed

46 The ability to robustly design membrane-permeable and orally bioavailable peptides with

47 reted into the periplasm to oxidize the more membrane-permeable and toxic Cu(I) before it can enter t

48 are protease resistant, structurally rigid, membrane permeable, and capable of modulating protein-pr

49 ration-dependent, required the ligands to be membrane permeable, and was not the result of the revers

50 Systemic administration of a membrane-permeable antioxidant prevented oxidative stres

51 Preincubation of cells with membrane-permeable antioxidants, pyrrolidine dithiocarba

52 e myelogenous leukemia (AML), we studied the membrane-permeable arsenic compound phenylarsine oxide (

53 canning confocal microscopy show SPI is cell membrane-permeable, associates with the cytoplasmic tail

54 actin organization responses to IAA and the membrane-permeable auxin 1-naphthylacetic acid (NAA).

55 on Green diacetate succinimidyl ester, and a membrane-permeable base to raise intramitochondrial pH.

56 Membrane-permeable biarsenical compounds FlAsH and ReAsH

57 We have found that membrane-permeable bioagents can be rendered membrane im

58 ectable oligomers upon addition of AP1510, a membrane-permeable, bivalent FKBP ligand.

59 Specific inhibitors and membrane permeable blocking peptides were used to determ

60 lls with the inhibitors, which were rendered membrane permeable by attachment of an octaarginine sequ

61 ZO-1 (PDZ)-binding sequence of DAT, was made membrane-permeable by fusing it to the cell membrane tra

62 e whether stapled peptides are intrinsically membrane permeable, by performing a case study on a stap

63 ponse was induced by 1 nM TNF, the synthetic membrane-permeable C-2, C-6, and C-8 ceramides had no ef

64 Acetazolamide, a membrane-permeable CA inhibitor, was used to inhibit tot

65 rate that both transient Ca(2+) depletion by membrane-permeable Ca(2+) chelators and chronic blockage

66 taining either TTX, low Ca2+ plus Cd2+, or a membrane permeable Ca2+ chelator BAPTA-AM (when BAPTA wa

67 GS on mEPSCs, as did pertussis toxin and the membrane-permeable Ca2+ chelator 1,2-bis(2-aminophenoxy)

68 A membrane-permeable calcineurin inhibitor, however, still

69 Furthermore, the membrane-permeable calcium chelator BAPTA-AM had no effe

70 We find that treating cells with the membrane-permeable calcium chelator, 1,2-bis(2-aminophen

71 raacetic acid, tetra(acetoxymethyl)-ester, a membrane-permeable calcium chelator, inhibits MMS-induce

72 Membrane-permeable calmodulin inhibitors, such as the na

73 Studies with a selective membrane permeable calpain inhibitor indicated that tTG

74 acute hippocampal slices was prevented by a membrane-permeable calpain inhibitor.

75 ty in single muscle fibers was measured by a membrane-permeable calpain substrate.

76 Here we report that KN-93, a membrane-permeable CaMKII inhibitor, blocked glutamate-i

77 ypes affecting PMN excitability, we used the membrane permeable cAMP analog 8-bromo-cAMP (8-Br-cAMP)

78 bol 12-myristate 13-acetate (PMA), but not a membrane permeable cAMP analog induced rapid phosphoryla

79 pendent stimulation of I(Ca,T) by 8-Br-cAMP (membrane permeable cAMP analog) was abolished by siRNA d

80 ning various concentrations of 8-CPT-cAMP, a membrane permeable cAMP analog, for 2 h.

81 ats, and (3) the tachycardia elicited by the membrane permeable cAMP-analogue, 8-(4-chlorophenylthiol

82 n, an activator of adenylyl cyclases, and by membrane-permeable cAMP analog (dbcAMP), exhibit a bipha

83 hniques and have examined the effects of the membrane-permeable cAMP analog 8-(4-chlorophenylthio) (C

84 Furthermore, a membrane-permeable cAMP analog 8-(4-chlorophenylthio)-cA

85 The membrane-permeable cAMP analog 8-pcpt-cAMP also reduced

86 After bath application of the membrane-permeable cAMP analog adenosine 3',5'-cyclic mo

87 Consistent with this, a membrane-permeable cAMP analog and a cAMP-elevating agon

88 pid, occurring within 5 min of exposure to a membrane-permeable cAMP analog, indicative that threshol

89 ed by 2.5 to 25 nmol 8-bromo-cAMP (n = 4), a membrane-permeable cAMP analog.

90 proximately 4.5 h in cells stimulated with a membrane-permeable cAMP analog.

91 rons at relatively low concentrations of the membrane-permeable cAMP analogs (20-50 microM).

92 Bath application of the membrane-permeable cAMP analogs 8-bromo-cAMP (8-Br-cAMP)

93 Membrane-permeable cAMP analogs are reported to rescue t

94 ntly enhanced when A-kinase was activated by membrane-permeable cAMP analogs or when cells were cotra

95 selves but rather the hydrolyzed products of membrane-permeable cAMP analogs that prevent proliferati

96 activator forskolin as well as two cellular membrane-permeable cAMP analogs, dibutyryl cAMP and 8-br

97 lementing the preservation solution with the membrane-permeable cAMP analogue dibutyryl-cAMP resulted

98 Similar results were obtained with the membrane-permeable cAMP analogues dibutyryl-cAMP and 8-b

99 he effects of forskolin were not mimicked by membrane-permeable cAMP analogues.

100 The membrane-permeable cAMP derivative, 8-bromo cAMP (0.1 to

101 We have used synthetic membrane-permeable cathepsin substrates, which liberate

102 ng cGMP in cells by addition of 8-Br-cGMP (a membrane permeable cGMP analogue) did not reproduce the

103 Root exposure to 10 mum membrane permeable cGMP induced changes in abundance for

104 mimicked when cells were pre-treated with a membrane-permeable cGMP analog and blocked by pharmacolo

105 Treating cells with a membrane-permeable cGMP analog partly mimicked the effec

106 t in response to the extracellularly applied membrane-permeable cGMP analog pCPT-cGMP (50 muM), which

107 and detachment from the substratum and by a membrane-permeable cGMP analog, a known regulator of str

108 Bath application of the membrane-permeable cGMP analogs 8-bromo-cGMP (B-cGMP) an

109 onfluent monolayers were treated with ANP or membrane-permeable cGMP analogs in the presence of anant

110 NO donors on COX-2 mRNA expression; (b) the membrane-permeable cGMP analogue, 8-Br-cGMP, mimicked th

111 A membrane-permeable cGMP analogue, 8-Br-cGMP, mimics the

112 ion of vascular smooth muscle cells with the membrane-permeable cGMP analogues, dibutyryl cGMP and 8-

113 rongly buffering intracellular Ca2+ with the membrane-permeable chelator BAPTA-AM (10 microM) signifi

114 Chelation of Zn(2+) with the membrane-permeable chelator N,N,N',N'-Tetrakis(2-pyridyl

115 Using a membrane-permeable chelator of zinc or a mutant TRAF2 mo

116 (c) Membrane-permeable chelators stop but do not reverse enz

117 In contrast, filipin and other membrane-permeable cholesterol-binding agents (digitonin

118 Treatment of cells with membrane permeable CK1 inhibitor 3-[(2,3,6-trimethoxyphe

119 Chelating intracellular Ca2+ using the membrane-permeable compound BAPTA-AM, abolished the effe

120 Fic gives insights on membrane-permeable compounds in terms of cellular potenc

121 The proinhibitors are designed as neutral, membrane-permeable compounds that once inside the cell m

122 Membrane-permeable compounds that reversibly inhibit a p

123 acted for each peptide the population of the membrane-permeable conformation in water from extensive

124 ool, we have synthesized and characterized a membrane-permeable, copper-selective fluorescent sensor

125 e intermolecularly cross-linked by using the membrane-permeable cross-linker bis-maleimido hexane.

126 e we show, using CSD mutants (F92A/V94A) and membrane-permeable CSD-competing peptides, that Src kina

127 roine disulfonic acid (BCPD, 100 muM), a non-membrane-permeable Cu chelator.

128 Neither forskolin nor a membrane permeable cyclic adenosine monophosphate analog

129 PAF and PMA, as well as a membrane permeable cyclic AMP analog, stimulated phospho

130 Moreover, addition of membrane permeable cyclic nucleotides during growth assa

131 for the discovery of geometrically diverse, membrane permeable cyclic peptide scaffolds based on the

132 While neither epinephrine, forskolin, nor a membrane-permeable cyclic AMP analog induced reactivatio

133 A (PKA), phosphodiesterase 3B (PDE3B), and a membrane-permeable cyclic guanosine monophosphate (cGMP)

134 Exposure to the membrane-permeable cyclic nucleotide analogue CPT-cAMP e

135 macroscopic IRKC that was suppressed by the membrane-permeable cyclic nucleotide Sp-cAMP but was una

136 the EAAC1(-/-) mice with N-acetylcysteine, a membrane-permeable cysteine precursor.

137 1(-/-) mouse to evaluate N-acetylcysteine, a membrane-permeable cysteine pro-drug, as a potential dis

138 substances mimicked the inhibitory effect of membrane-permeable cysteine-reactive compounds on PC2 F6

139 2 L677A N681A, could be inhibited by several membrane-permeable cysteine-reactive compounds.

140 photoaffinity nucleotide analogue and a non-membrane-permeable cysteine-specific chemical cross-link

141 hole cytoplasmic tails, to the labeling of a membrane-permeable, cysteine-specific chemical biotin ma

142 l wall proteins were biotinylated with a non-membrane-permeable derivative to distinguish extracellul

143 Membrane-permeable DG also drove perilipin 4 and 5 onto

144 Treating cells with a membrane-permeable DG recruited perilipin 3 to the ER.

145 12-O-tetradecanoylphorbol-13-acetate or with membrane-permeable diacylglycerols also stimulated PKD a

146 Similarly, addition of membrane-permeable dibutyryl cAMP, like alpha-MSH, suppr

147 rminal SUMO-interacting motif (SIM2) is cell-membrane permeable, disrupts the DAXX-SREBP1/2 interacti

148 A membrane permeable DNA-associating vital dye, ethidium b

149 Inactivation of Nrf2 by antisense or by a membrane permeable dominant-negative polypeptide sensiti

150 due to steric hindrance, and addition of the membrane-permeable drug 4-hydroxytamoxifen (4-HT), which

151 linkers cleavable by lysosomal proteases and membrane-permeable drugs, mediating a bystander effect b

152 nside cells, and then the corresponding cell membrane permeable dye molecules are added, imaged, and

153 broventricular perfusion in rats of the cell membrane-permeable dye diaminofluorescein-2/diacetate (D

154 f the mitochondrion relies on the use of the membrane-permeable dye, Oregon Green diacetate succinimi

155 lorofluorescein, fluorescent products of the membrane-permeable dyes hydroethidine and 2',7'-dichloro

156 ersal labelling method based on the organic, membrane-permeable dyes SiR and ATTO590 as Halo and SNAP

157 ent inhibitor reduced the growth of an outer membrane-permeable E. coli strain, concurrent with the e

158 Isothiocyanates are membrane-permeable electrophiles that form adducts with

159 orneal endothelial cells were established on membrane-permeable filters.

160 ation initiated by addition of the bivalent, membrane-permeable FKBP dimerizer, AP1510, nearly double

161 teine tag that tightly binds the fluorescent membrane-permeable FlAsH ligand.

162 A tetracysteine motif that binds the membrane-permeable fluorescein derivative 4',5'-bis(1,3,

163 Coppersensor-1 (CS1) is a small-molecule, membrane-permeable fluorescent dye for imaging labile co

164 Calpain-mediated proteolysis of the membrane-permeable fluorescent substrate N-succinyl-L-le

165 ChromEMT exploits a membrane-permeable, fluorescent DNA-binding dye, DRAQ5,

166 logically compatible, water-soluble and cell-membrane-permeable fluorophores, termed OregonFluor (ORF

167 A cell membrane-permeable form of 2',3'-cAMP and 3'-AMP mimicke

168 enosine-3',5'-cyclic monophosphate (db-cAMP, membrane-permeable form of cAMP), the bell-shaped voltag

169 ntaining either ammonium chloride or E64d, a membrane-permeable form of E64, was added at various tim

170 Here we report that cell membrane-permeable forms of such peptides preferentially

171 A cell membrane-permeable fusion peptide derived from the uniqu

172 In addition, membrane-permeable Galpha(i2)- and Gbetagamma-blocking p

173 Instead, membrane-permeable gamma-secretase inhibitors, but not a

174 meaning that it is an endogenously produced membrane permeable gas that carries out essential cellul

175 A membrane-permeable glutamate analog (dimethylglutamate [

176 the thiol-anti-oxidant N-acetyl-cysteine or membrane-permeable glutathione.

177 reen of 4,096 known compounds identified two membrane permeable GO inhibitors: dichromate salt and co

178 alysis of induction of GPIbalpha shedding by membrane-permeable GPIbbeta-derived peptides implicated

179 zed and externally functionalized by pendant membrane-permeable groups.

180 ence probes are unsuitable, we have designed membrane-permeable HMRef-betaGal, in which the optimized

181 ve transport involved the incorporation of a membrane permeable import function previously shown to c

182 oteins, remarkable for their ability to make membranes permeable in a temporally regulated manner.

183 of slices with calyculin A, a selective and membrane permeable inhibitor of protein phosphatases 1 a

184 Here we show that a novel membrane-permeable inhibitor of 14-3-3zeta-GPIbalpha int

185 Local application of okadaic acid, a membrane-permeable inhibitor of phosphatase 1 and 2A, to

186 A membrane-permeable inhibitor of protein kinase A, myrist

187 Both wortmannin and LY294002, membrane permeable inhibitors of phosphoinositide 3-kina

188 Inhibition of calpain with membrane permeable inhibitors or by expression of a domi

189 cells with fibroblasts was inhibited by cell membrane-permeable inhibitors of cathepsins B/L, but not

190 The specific, membrane-permeable inositol 1,4, 5-trisphosphate (Ins-1,

191 mGluR1/5 and NR2B glutamate receptors; (ii) membrane-permeable inositol 1,4,5-trisphosphate receptor

192 4,5-trisphosphate (InsP(3)) receptors with a membrane-permeable InsP(3) ester (InsP(3) BM) mimicked t

193 Pre-treatment with the membrane-permeable InsP3 receptor antagonist 2-APB block

194 The rate of cellular uptake of membrane-permeable, ionic fluorophores by THP-1 cells wa

195 plasmolysis, whereas a shock caused by outer-membrane permeable ions causes plasmolysis immediately u

196 Xe's represent a new class of potent, membrane permeable IP3 receptor blockers exhibiting a hi

197 he intracellular free iron content using the membrane-permeable iron chelator 2,2'-dipyridyl effectiv

198 A membrane-permeable iron chelator substantially reduces N

199 Rather, studies using a membrane-permeable iron chelator, salicylaldehyde isonic

200 p-regulated by desferrioxamine (DFO), a cell membrane-permeable iron chelator.

201 rotein domain (to permit dimerization by the membrane-permeable ligand AP20187) with or without a myr

202 the cytoplasm when the two are tethered by a membrane-permeable ligand.

203 Both membrane-permeable ligands like nicotine and much less p

204 PTEN-Long is a membrane-permeable lipid phosphatase that is secreted fr

205 om fractionated endosomes was assessed using membrane-permeable (luminol and lucigenin) and -impermea

206 (Cu) with high affinity and as an endogenous membrane permeable metabolite could be advantageous in m

207 as directly targeting complex II using cell membrane-permeable metabolites also controlled infection

208 CD30-targeting ADC delivering membrane permeable MMAE or pyrrolobenzodiazepine dimers

209 APB) has been extensively used recently as a membrane permeable modulator of inositol-1,4,5-trisphosp

210 interfering RNAs (siRNAs) conjugated to the membrane permeable molecule Penetratin to injured sensor

211 acid peptide that contains a lipophilic cell-membrane-permeable motif and a nuclear localization sequ

212 indings provide a new strategy for designing membrane-permeable N-methylated macrocycles and undersco

213 hich decreases the proportion of drug in the membrane-permeable neutral form.

214 The membrane-permeable, noncompetitive inositol 1,4,5-trisph

215 4-chlorophenylthio)-cyclic GMP (CPT-cGMP), a membrane-permeable, nonhydrolyzable analogue of cGMP, re

216 atives; pyrimidines, purine nucleotides, and membrane-permeable, nonhydrolyzable cyclic nucleotide an

217 mulations of paclitaxel and Hoechst 33342, a membrane-permeable nuclear staining dye, were reduced to

218 The E. coli were labeled with a membrane-permeable nucleic acid stain (Syto15), a membra

219 Using the membrane-permeable nucleic acid stain SYTO 14, we direct

220 In this study, using membrane-permeable nucleotide analogs, we show that it i

221 ively, so that only the neutral radicals are membrane-permeable on the time scale of the transmembran

222 membranes using reductants that were either membrane-permeable or -impermeable.

223 reproduced by treating mesangial cells with membrane-permeable oxidants.

224 In contrast, a less membrane permeable payload, MMAF, failed to mediate byst

225 Consistent with this hypothesis, membrane-permeable pCPT-cAMP rescues the prolapse phenot

226 Herein, we use two membrane permeable peptide aldehyde protease inhibitors,

227 nhibitor of CaMKII, blocked run-up, as did a membrane permeable peptide corresponding to the CaMKII a

228 A membrane-permeable peptide (KV1-C peptide) corresponding

229 A membrane-permeable peptide containing residues 476-485 o

230 Notably, a plasma membrane-permeable peptide derived from GADD45-alpha, th

231 the phosphorylation of Ser726 on Add1 with a membrane-permeable peptide effectively rescues the memor

232 A 10-aa-long rhodamine-linked and membrane-permeable peptide inhibitor (PBP10) has such a

233 and Cx43, by genetic tagging of Cx43 or by a membrane-permeable peptide inhibitor that contains the C

234 We generated a membrane-permeable peptide mimetic of the PTPsigma wedge

235 Finally, treating myocytes with a membrane-permeable peptide representing beta(1)AR PDZ mo

236 ut myocytes is inhibited by treatment with a membrane-permeable peptide representing the beta2AR carb

237 Moreover, an exogenously applied membrane-permeable peptide that competes for Tau-vesicle

238 We found that a membrane-permeable peptide that disrupts mGluR5 interact

239 Thus, conjugated, membrane-permeable peptides are effective tools for the

240 Constrained, membrane-permeable peptides offer the possibility of eng

241 strategy entails the delivery of conjugated membrane-permeable peptides that disrupt domain interact

242 Through use of a newly developed set of membrane-permeable peptides that separately inhibit eith

243 1 in wild-type mice, dominant negative Ets-1 membrane-permeable peptides were administered systemical

244 Using both siRNA and membrane-permeable peptides, we show that alphavbeta6-de

245 r results will facilitate the development of membrane-permeable peptides.

246 probed by weakening it in situ with urea, a membrane-permeable perturbant of spectrin.

247 in MCF-10A cells treated with DAG-lactone, a membrane permeable PKC activator.

248 erally resistant to high levels of these two membrane-permeable poisons.

249 The ester-protected analog DFSA (PDFSA) is a membrane-permeable precursor of DFSA designed to be used

250 on of mero166 to a small molecule produced a membrane-permeable probe that reported the localization

251 Here we describe that cell membrane-permeable prodrugs of the complex II substrate

252 an be applied to targeting the activation of membrane permeable properties in mildly acidic pH enviro

253 ect effects of dopamine receptor ligands and membrane-permeable protein kinase ligands on ganglion ce

254 ssion in many clinically relevant pathogens, membrane-permeable quorum sensing antagonists that preve

255 Here, we investigate the effects of a membrane-permeable radical scavenger (tempol) on the cir

256 Intravitreal injection of membrane-permeable radical scavenger but not vehicle bef

257 single cysteine-containing mutants using the membrane-permeable reagent 3-(N-maleimidylpropionyl)bioc

258 e mitochondrial redox status and responds to membrane-permeable reductants and oxidants.

259 STING, but is rapidly metabolized and poorly membrane permeable, restricting its use to intratumoral

260 e live cell uptake properties of a dinuclear membrane-permeable Ru(II) cell probe show that, at low c

261 through a chemoenzymatic strategy to process membrane-permeable S-alkyl analogues of methionine (SAAM

262 by S-nitrosylation through exposure to cell membrane-permeable S-nitrosothiols and that sGC is S-nit

263 torial library, followed by deconvolution of membrane-permeable scaffolds to identify cyclic peptides

264 NMDA antagonist dizocilpine(MK-801) and by a membrane-permeable scavenger of ROS.

265 ent with the NMDA antagonist MK-801 and by a membrane-permeable scavenger ofROS.

266 accomplished by incorporating a hydrophobic, membrane-permeable sequence (MPS).

267 further development of potent, specific, and membrane-permeable SH2 domain inhibitors.

268 nsitive (HIDE) membrane probes, based on the membrane-permeable silicon-rhodamine dye HMSiR, that ass

269 Structural optimization generated membrane-permeable, slow off-rate inhibitors that preven

270 The membrane-permeable small molecule activators TPC2-A1-N a

271 In the present paper, we have used a novel membrane-permeable, small-molecule inhibitor of GRK2 and

272 ion of impermeable osmolytes such as KCl and membrane-permeable solutes such as weak acids.

273 y stimulate NAADP signaling, MASTER-NAADP, a Membrane permeAble, STabilized, bio-rEversibly pRotected

274 Consistent with this interpretation, a membrane-permeable stabilizer of F-actin, jasplakinolide

275 have access to their recently described (non-membrane-permeable) substrates.

276 e-2,2'-disulfonic acid (AMS) followed by the membrane permeable sulfhydryl reagent 3-(N-maleimidylpro

277 PDI and beta-actin could be abolished by the membrane-permeable sulfhydryl blocker, N-ethylmaleimide,

278 sponsible for methyl methanethiosulfonate (a membrane-permeable sulfhydryl modifier)-mediated enhance

279 An nNOS inhibitor or a membrane-permeable superoxide dismutase (SOD) mimetic pr

280 directly to TRPML1 and elicited by a potent membrane-permeable synthetic agonist, is dramatically re

281 wing mutant seedlings in the presence of the membrane-permeable synthetic auxin, 1-naphthaleneacetic

282 nt of physiological levels of ZAP70 with the membrane-permeable synthetic ligand FK1012A leads to rap

283 ition of PC cleavage in PC12 cells using the membrane-permeable synthetic peptide chloromethyl ketone

284 ently-acting Runx1.d190, we generated a cell membrane-permeable TAT-Runx1.d190 fusion protein.

285 point mutants, and specific inhibition by a membrane-permeable TAT-V peptide--we demonstrate that th

286 oxaz is stable in human plasma and is poorly membrane permeable, thereby limiting activation to local

287 nal domains of these subunits, we utilized a membrane permeable, thiocleavable cross-linking reagent

288 Designs with exposed NH groups can be made membrane permeable through the design of an alternative

289 otein which may render the T. pallidum outer membrane permeable to nutrients while remaining inaccess

290 trations of digitonin to render their plasma membrane permeable to succinate, ADP, safranin O, and ot

291 '-deoxyriboside (MeP-dR) to the highly toxic membrane permeable toxin, 6-methylpurine (MeP).

292 le ascorbate/TMPD was 1.23 times that of the membrane permeable ubiquinol.

293 Moreover, we show that a cellular membrane permeable version of the peptide corresponding

294 To generate a membrane-permeable version of the anti-Akt1 scFv, the sc

295 uorescence was quenched by the addition of a membrane-permeable weak base, methylamine.

296 e)](+) with the anionic ligand pyrithione is membrane permeable, which circumvents the need to utiliz

297 able in vivo conditions, SMTA is found to be membrane-permeable while SSETA is not.

298 nt of human T lymphocytes with a recombinant membrane-permeable YopH resulted in severe reduction in

299 eatment of the human Jurkat T-cell line with membrane permeable zinc chelators disrupts CD4.p56(lck)

300 Using the membrane-permeable zinc chelator, N,N,N',N'-tetrakis-(2-