ライフサイエンスコーパス: memory T-cell

1 erequisite to become a long-lived protective memory T cell.

2 eatures of central memory and stem cell-like memory T cells.

3 ion of pathogen-specific CD8 tissue-resident memory T cells.

4 y CD4(+) T cells but enhanced that of CD8(+) memory T cells.

5 by increased levels of TCF7(+) naive and/or memory T cells.

6 hanced and accelerated development of CD8(+) memory T cells.

7 ctivation after they return to quiescence as memory T cells.

8 okine release that resembled those of normal memory T cells.

9 ced phenotype of central memory and effector memory T cells.

10 y with CD8(+)CD103(+)CD69(+) tissue-resident memory T cells.

11 in-domain containing-3 (Tim-3) expression on memory T cells.

12 ed by a site-specific recruitment process of memory T cells.

13 T, an inhibitory molecule on CD8(+) effector memory T cells.

14 o elevated pretransplant frequencies of CD28 memory T cells.

15 d their differentiation into tissue-resident memory T cells.

16 e T cells, and generation and maintenance of memory T cells.

17 p that is otherwise required by conventional memory T cells.

18 companied by increased frequency of effector memory T cells.

19 to generate memory precursors and long-lived memory T cells.

20 states and a novel subset of tissue-resident memory T cells.

21 inst future immune challenges is mediated by memory T cells.

22 tome toward a profile of more differentiated memory T cells.

23 cell subsets, that is, naive, effector, and memory T cells.

24 oxic features that is distinct from effector memory T cells.

25 tribute to the maintenance of viral-specific memory T cells.

26 is a marker for long-lived antigen-specific memory T cells.

27 and minimized CD4(+)CD103(+) tissue-resident memory T cells.

28 nctional CD44(high)CD62L(high)CD8(+) central memory T cells.

29 transcriptionally distinct stem-like CD8(+) memory T cells.

30 haracteristics compared to naive and central memory T cells.

31 creased Bhlhe40(+) Th1-like cells and CD8(+) memory T cells.

32 n and induces a population of stem cell-like memory T cells.

33 l of WNT transcription factor TCF7-dependent memory T cells.

34 r immunity, including CD8(+) tissue-resident memory T cells.

35 not in naive ferrets, suggests induction of memory T-cells.

36 infiltration of antitumor CD8+ effector and memory T-cells.

37 companied by increased frequency of effector memory T-cells.

38 r cytokines supported the finding that CCR9+ memory T cells acquire a more inflammatory profile in SP

39 B cells were required for the generation of memory T cells after allotransplantation.

40 he establishment of circulating and resident memory T cells after foodborne Listeria monocytogenes in

41 diated B cell depletion on CD4(+) and CD8(+) memory T cell alloresponses after skin transplantation i

42 , and IL-12, successfully stimulates central memory T cells and achieves long-term survival in an agg

43 ion-protective human lymphoid tissue central memory T cells and autoimmune-protective human blood reg

44 ignificantly reduced infiltration of central memory T cells and B cells into the lungs.

45 ction of CD44(high)CD62L(low)CD8(+) effector memory T cells and CD103(high)CD8(+) tissue-resident T c

46 The proportions of both effector memory T cells and central memory T cells were reduced,

47 ckade (ICB) increases the number of effector memory T cells and completely eradicates 4T1 tumors in m

48 g reduced CD4(+) central memory and effector memory T cells and diminished systemic interferon-gamma

49 rized by expansion of IL17A+ CD161+ effector memory T cells and IL17A+ T-regulatory cells; expansion

50 ling and differentiation, expanding effector-memory T cells and inducing robust viral reactivation in

51 igher IFN-gamma production in peripheral CD4 memory T cells and lymph node-derived follicular helper

52 adaptive memory cells, including follicular memory T cells and memory B cells (B(mems)), that are ei

53 Here, we used ex vivo stimulation of memory T cells and screening of naive and memory T cell

54 t cytokine known to promote proliferation of memory T cells and T helper type 17 cells.

55 to differentiate into T(CM) cells, effector memory T cells and T(RM) cells on recall.

56 reported that AQP4 is expressed by naive and memory T cells and that AQP4 blockade with a small molec

57 rotection by generating central and effector memory T cells and the most recently described tissue re

58 w discusses recent updates on the biology of memory T cells and their relevance to the field of trans

59 stem T cell, central memory T cell, effector memory T cell, and terminally differentiated effector T

60 emokine that induces migration of monocytes, memory T cells, and dendritic cells.

61 ized by a metabolism typical of quiescent or memory T cells, and did not participate in inflammatory

62 significantly enhanced local control, CD8(+) memory T cells, and induced preferential T-cell homing v

63 ression in TH1 polarized PBMC cultures, CD4+ memory T cells, and NK cells.

64 Memory T cells are endowed with multiple functional feat

65 (2019) show that virus-unspecific bystander memory T cells are highly affected during chronic viral

66 latory elements of the cytokine genes in the memory T cells are marked by activating histone modifica

67 we show that protein vaccine-elicited CD4(+) memory T cells are recalled and boosted after infection

68 Autoreactive resident memory T cells are responsible for relapse, and new trea

69 Bystander memory T cells are strongly decimated in numbers and cha

70 Memory T cells are unable to differentiate into the Th2

71 ment is accompanied by increased circulating memory T cells, as well as fewer effectors, suggesting a

72 causal variants, implicating CD4 + effector memory T cells, as well as monocytes, B cells and stroma

73 The presence of tissue-resident memory T cells at barrier tissues is critical for long-l

74 ng toward myeloid development, and increased memory T cells at the expense of naive T cells.

75 nger accurately reflect our understanding of memory T cell biology.

76 IFN-gamma and granzyme-B secreting effector memory T cells but remain as long-lived and hyperprolife

77 required for residence of epidermal-resident memory T cells, but whether skin-derived signals also af

78 avoiding the loss of CD28(+)/CD95(+) central memory T cells by differentiation in culture.

79 Here we report that memory T cell bystander activation is not limited to ind

80 Previous work has shown that tissue-resident memory T cells can be established by "pulling" virus-spe

81 The fact that CD8(+) memory T cells can have features of both naive and effec

82 While CXCR3 promotes memory T cells, CCR4 supports short-lived effector cell

83 in the proportion of CCR9+ cells among CD4+ memory T cells (%CCR9) in SPMS did not correlate with ag

84 y DCs (CD1A(+)FCER1A(+)) and tissue-resident memory T cells (CD69(+)CD103(+)).

85 nally distinct from other secondary effector memory T cell cells.

86 Autoantigen-reactive CD4(+) memory T cell clones and an APS-derived, pathogenic mono

87 Here, we show that memory T cells collapsed in secondary lymphoid organs in

88 splayed decreased numbers of tissue-resident memory T cells compared with H1N1-infected mice; however

89 elates significantly with a shift toward the memory T cell compartment in SAT.

90 nt mice have a pronounced expansion of their memory T cell compartment.

91 expansion of memory stem T cells and central memory T cell-derived T cells compared with IL-2.

92 doptive transfer studies indicate that these memory T cells develop in a cell-intrinsic manner follow

93 conceptual advances in our understanding of memory T cell development that incorporate data describi

94 affinity independently contribute to CD8(+) memory T cell development, which is modulated by inflamm

95 IK is an important regulator of effector and memory T cell differentiation and induces a population o

96 ucing T helper cell responses, and promoting memory T cell differentiation and maintenance.

97 as in turn significantly associated with CD8 memory T-cell differentiation (effector memory, naive, a

98 TH1, TH17, and CD8(+) memory T-cell differentiation was significantly reduced,

99 1 persists as an integrated genome in CD4(+) memory T cells during effective therapy, and cessation o

100 ay be used to tune the development of CD8(+) memory T cells during vaccine development.

101 of naive T cell, memory stem T cell, central memory T cell, effector memory T cell, and terminally di

102 LA-DQ8 transgenic (model 2), and the gliadin memory T-cell enteropathy (model 3) models of celiac dis

103 lluminate how targeting pathways that induce memory T cell exhaustion can promote allograft tolerance

104 n as antigen-presenting cells for intragraft memory T cell expansion but not to alloantibody producti

105 road changes in adaptive immunity, including memory T-cell expansion, and rising prevalence of diabet

106 In healthy individuals, CCR9+ memory T cells expressed higher levels of CCR6, a CNS-ho

107 Here, we analyse human CD4+ memory T cells expressing the gut-homing chemokine recep

108 Here we show that virus-specific memory T cells extend their surveillance to mouse and hu

109 fferentially affected effector T cell versus memory T cell fates, respectively, highlighting their di

110 Thus, unlike memory T cells for which secondary expansion requires CD

111 ompetitive disadvantage resulting in reduced memory T cell formation and maintenance and reduced resp

112 rogresses from naive to central and effector memory T cells, forming an effectorness gradient accompa

113 Among the memory T cells found in skin are both recirculating cell

114 uantified as a reduction in splenic effector memory T cell frequencies and splenic T helper 17 cells

115 d CD4(+) naive and increased CD4(+) effector memory T cell frequencies were associated with improved

116 CCR9+ memory T cell frequency decreased in germ-free mice, whe

117 timulation and cell enrichment of peripheral memory T cells from six metastatic cancer patients, we i

118 ures to analysis of islet Ag-reactive CD4(+) memory T cells from the blood of T1D and HC individuals

119 cy-reversing agents (LRAs) in ex vivo CD4(+) memory T cells from virally suppressed HIV-infected indi

120 secondary infection with influenza PR8, and memory T-cell function and T-cell metabolism were measur

121 pite the decreased number of tissue-resident memory T cells, H5N1 (2:6) was protected against a heter

122 expression on antigen-specific effector and memory T cells has not been investigated.

123 s the expression of CD103 on tissue-resident memory T cells, has been implicated in HIV latency.

124 These characteristics of memory T cells have mainly been studied during viral inf

125 Memory T cell homing to BM during DR was associated with

126 or the detection of rare neoantigen-specific memory T cells in cancer patients for studying cellular

127 kinetics of circulating and tissue-resident memory T cells in mice infected with murine CMV.

128 ata demonstrate the accumulation of effector memory T cells in obese SAT and an association between s

129 chanics, and effector responses between CD8+ memory T cells in peripheral vs. lymphoid organs, reveal

130 as associated with the emergence of effector memory T cells in responding patients, while nonresponde

131 with proinflammatory and activated effector memory T cells in the blood, evidence of treatment effic

132 infections generate antigen-specific CD8(+) memory T cells in the brain that adopt a unique T(RM) si

133 einfection, a sizeable fraction of secondary memory T cells in the circulation developed downstream o

134 upport the accumulation of HCV-specific CD8+ memory T cells in the infected liver, and emphasize the

135 view, we will discuss how influenza-specific memory T cells in the lung are established and maintaine

136 CCR9 and found a reduced frequency of CCR9+ memory T cells in the peripheral blood of patients with

137 and was accompanied by an increase in CCR9+ memory T cells in the peripheral blood.

138 as well as a rapid expansion of effector and memory T cells in the spleen.

139 While females had more memory T cells in their nodes, males had a higher percen

140 ased effector T-cell function, and increased memory T cells in tumor microenvironment.

141 t a critical role for cross-reactive central memory T cells in viremia control.

142 r, our data provide characterization of skin memory T cells in vitiligo, demonstrate that Trm and Tcm

143 cytotoxicity and characteristic of effector memory T cells, including CCL4, GNLY and NKG7.

144 cumulated large numbers of pathogen-specific memory T cells, including tissue-resident cells.

145 rthermore, lymphatic exudate was enriched in memory T cells, including tumor-reactive CD137(+) and st

146 sociated lncRNA abrogates IFNG expression by memory T cells, indicating these lncRNAs have biologic f

147 d provides new insights into the location of memory T cells infected with HIV-1 DNA, which is capable

148 The study of human memory T cells is often restricted to in vitro studies a

149 ating 3 gene (LAG3) was detected among CCR9+ memory T cells isolated from the CSF, similar to that ob

150 onment impacts the phenotype and function of memory T cells, it is crucial to study these cells withi

151 Finally, supernatants from IL-1beta-treated memory T cells killed Escherichia coli in an IL-26-depen

152 A subset of memory T cells known as CD8(+) resident memory T cells (

153 of memory T cells and screening of naive and memory T cell libraries, combined with T cell cloning an

154 n entering the ES T cells assumed a resident memory T cell-like phenotype in the absence of infection

155 activated CD8(+) T cells and is required for memory T cell maintenance.

156 ence and characterization of tissue resident memory T cells, manipulation of T cell metabolic pathway

157 aintenance of CD4(+)CD103(+) tissue-resident memory T cells, needed to replenish the vasculitic infil

158 In addition, memory T cell numbers were decreased in modified avian i

159 , we postulate that the alterations in CCR9+ memory T cells observed, caused by either the gut microb

160 Bystander activation of memory T cells occurs in the absence of cognate antigen

161 in SPMS, reporting similar aspects to CCR9+ memory T cells of the elderly healthy controls.

162 rios for the impact of cross-reactive CD4(+) memory T cells on COVID-19 severity and viral transmissi

163 controls, and this correlates with effector memory T cell percentage.

164 s that VZV-specific PCs and VZV-specific CD4 memory T cells persist up to 20 years after vaccination.

165 ntified an EOMES(+)CD69(+)CD45RO(+) effector memory T cell phenotype that was significantly more abun

166 xpand memory T cell pool exhibiting effector memory T cell phenotype, therefore offering great potent

167 al increase in TRM cells exhibiting effector memory T cell phenotype.

168 xpand memory T-cell pool exhibiting effector memory T-cell phenotype, therefore offering great potent

169 al increase in TRM cells exhibiting effector memory T-cell phenotype.

170 Alloreactive memory T cells play a key role in transplantation by acc

171 ver, which when lost resulted in a decreased memory T cell pool and thus a reduced secondary response

172 demonstrating its strong capacity to expand memory T cell pool exhibiting effector memory T cell phe

173 Multiple HCMV-directed specificities in the memory T cell pool of single individuals indicate that p

174 organizational structure of the human CD8(+) memory T cell pool under physiological conditions.

175 differentiation programs in the human CD8(+) memory T cell pool, with potentially broad implications

176 memory cells and rejoin the tissue-resident memory T-cell pool after cessation of IL-10 production.

177 demonstrating its strong capacity to expand memory T-cell pool exhibiting effector memory T-cell phe

178 nd persistence of the central and peripheral memory-T-cell pool.

179 for establishment of pre-existing protective memory T cell pools.

180 ared phenotypic properties with the effector memory T cell population but were transcriptionally and

181 Thus, T(NLM) may represent a memory T cell population that, if optimally targeted, ma

182 y and in the development of the effector and memory T cell populations that mediate long-term resista

183 T(RM) cells align closely with conventional memory T cell populations, bearing little resemblance to

184 me to have stem cell-like properties akin to memory T cell populations, but the developmental relatio

185 ls was required for the optimal formation of memory T cell populations, in particular TRM cell popula

186 Memory T cells possess functional differences from naive

187 Here, we also demonstrate that CCR9+ memory T cells preferentially infiltrate into the inflam

188 Circulating human memory T cells preferentially infiltrated ES and showed

189 Interestingly, we found that CD69(+) memory T cells produced higher levels of effector cytoki

190 ficacy with more IFN-gamma, IL-4, and CD8(+) memory T cells produced.

191 agocytic capacity, enhanced ability to drive memory T cell proliferation in coculture, and skewed CD4

192 Chronic antigen stimulation drives CD8+ memory T cell proliferation while also inducing genome-w

193 with potent effector function but maintained memory T cell qualities and conferred robust protection

194 However, the cytokine responses in memory T cells remain largely understudied.

195 red pathogen-specific immunity with a robust memory T-cell repertoire.

196 s technique to take full advantage of CD4(+) memory T-cell repertoires when designing immunotherapeut

197 ggest that white adipose tissue represents a memory T cell reservoir that provides potent and rapid e

198 Induction of memory T cell response is inefficient in colorectal canc

199 on and results in a CXCR5+ CCR7+ Tfh/central memory T cell response that persists well after parasite

200 response against the antigen, higher central memory T cell response, and lower regulatory T cell resp

201 ental steps are involved to elicit extensive memory T cell response: stimulation of naive T cells wit

202 Neither impaired memory T-cell response nor altered T-cell metabolism was

203 we investigated if weight loss would restore memory T-cell response to influenza.

204 expression of MHC-II and CD86, and induced a memory T-cell response, attenuating tumor onset and grow

205 za mortality and is associated with impaired memory T-cell response, resulting in increased risk of i

206 B cell depletion also impaired allospecific memory T cell responses and thereby enhanced donor hemat

207 Our data show that memory T cell responses elicited by prior infection with

208 Functional characterization revealed memory T cell responses in seropositive individuals for

209 RSV M-null infection generated serum Ab and memory T cell responses that were similar to those induc

210 Total memory T cell responses were measured after anti-CD3 sti

211 ts broadly directed and functionally replete memory T cell responses, suggesting that natural exposur

212 that exogenous IL-33 boosts vaccine-induced memory T cell responses, which protect against subsequen

213 g key roles in both naive T cell priming and memory T cell responses.

214 hich largely fail to elicit durable effector memory T cell responses.

215 nsion culture assay was also used to analyze memory T cell responses.RESULTSWe found responses to the

216 moted long-lasting, antigen-specific central memory T cell responses; and acted as a self-propelled v

217 ate neoepitopes were identified by recalling memory T-cell responses in vitro.

218 eased rates of hospitalization and decreased memory T-cell responses to tetanus vaccine were associat

219 Total memory T-cell responses were measured after anti-CD3 or

220 cell repertoire toward central and effector memory T cells, resulting in long-term cure.

221 Global profiling of reactivated memory T cells revealed tissue-defined and temporally re

222 CD4 tissue-resident memory T cells secrete interferon-gamma, which induces e

223 s associated with potent antiviral function: memory T cells secreted cytokines and expanded upon anti

224 -4 coinhibitory signals to control naive and memory T cells, selective antagonists of CD28-CD80/86 in

225 The host retains memory T cells specific for previous infections througho

226 is distinct from the functional effector or memory T cell states(1-6).

227 ut collectively constitute the most abundant memory T cell subset.

228 the generation and reactivation of different memory T cell subsets after transplantation.

229 changes in human CD4(+) and CD8(+) naive and memory T cell subsets at greater resolution using polych

230 Deep profiling identified 2 central memory T cell subsets at onset and 5 terminally differen

231 easingly clear that the terms used to define memory T cell subsets no longer accurately reflect our u

232 logy and propose a new approach for defining memory T cell subsets.

233 ncy and lowered PD-1 expression in naive and memory T cell subsets.

234 emia is associated with specific clusters of memory T-cell subsets and lower frequencies of HCMV-spec

235 ory cytokines and the relative proportion of memory T-cell subsets depending on Mtb infection status.

236 Following secondary influenza infection, memory T-cell subsets in the lungs of obese mice were de

237 Memory T cells sustain effector T-cell production while

238 ute effector T cell (T(AEFF)) to an effector memory T cell (T(EM)) phenotype with progressive enrichm

239 he molecular mechanisms that regulate CD8(+) memory T cell (T(M)) homeostasis.

240 the frequency of circulating CD4(+) central memory T cells (T(CM)) (CD45RO(+)CD62L(+)) in new-onset

241 beit transient, depletion of CD8(+) effector memory T cells (T(EM)) (but not the naive and central me

242 ain high frequencies of circulating effector memory T cells (T(EM)) providing continuous, life-long a

243 Pathogen-specific memory T cells (T(M)) contribute to enhanced immune prot

244 surface markers characteristic of naive-like memory T cells (T(NLM)), which were induced in both huma

245 Tissue-resident memory T cells (T(RM) cells) are a novel population of t

246 Tissue-resident memory T cells (T(RM) cells) are critical for cellular i

247 Although tissue-resident memory T cells (T(RM) cells) have been shown to regulate

248 Such CD8(+) tissue resident memory T cells (T(RM)) are critical for pathogen control

249 t of memory T cells known as CD8(+) resident memory T cells (T(RM)) are long-lived, nonmigratory memo

250 NKT cells (iNKT) and CD8(+) tissue-resident memory T cells (T(RM)) express high levels of the extrac

251 In recent years, tissue-resident memory T cells (T(RM)) have emerged as essential compone

252 Resident memory T cells (T(RM)) in the lung are vital for heterol

253 Skin tissue resident memory T cells (T(RM)) provide superior protection to a

254 surveillance strategies with CD8(+) resident memory T cells (T(RM)).

255 nst tumors, whereas IL-21 promotes stem cell memory T cells (T(SCM)) and antitumor responses.

256 lation of unconventional CD44+CD122+ virtual memory T cells (T(VM)) has been described that possesses

257 e identified and isolated CD4(+), and CD8(+) memory T cells targeting the mutated KRAS(G12D) and KRAS

258 Therefore, memory T cells targeting unique as well as shared somati

259 l relationship between Trm and recirculating memory T cells (Tcm) in our vitiligo mouse model.

260 her pre-treatment frequency of CD4 + central memory T cells (TCM) in patients who were subsequently A

261 we observed increased numbers of BAL central memory T-cells (Tcm), evidence of Type I polarization, a

262 unofluorescence to characterize CD8 effector memory T cell (TEM) populations in the periphery and gra

263 from classically described cytotoxic CD4(+) memory T cells that accumulate during other persistent v

264 resulting in the generation of effector and memory T cells that are then critical for immune clearan

265 g to generation of CD4 effector and effector memory T cells that contribute to protection.

266 e been proposed to induce commensal-specific memory T cells that cross-react with tumor-associated an

267 aptive immunity, differentiating into CD8(+) memory T cells that form the basis of protective cellula

268 odies, neutralizing plasma, and memory B and memory T cells that persisted for at least 3 months.

269 Human skin contains a population of memory T cells that supports tissue homeostasis and prov

270 stinguish CD8-MP cells from bona fide CD8(+) memory T cells, the developmental origins and antigen sp

271 However, in CCR9+ memory T cells, the expression of RORgammat was specific

272 on depletion of circulating and perivascular memory T cells, this brain signature was enriched and th

273 8 T cell response and reduces the ability of memory T cells to be recruited to the site of infection

274 ve immunity is the development of long-lived memory T cells to curtail infection.

275 the replenishment potential and capacity of memory T cells to respond to immune challenges.

276 n of airway T(RM) cells and splenic effector-memory T cells transferred into the airways indicated th

277 ocyte-derived APC (MoAPC) in tissue-resident memory T cell (Trm) formation.

278 CD8+ tissue-resident memory T cells (TRM cells) are poised at the portals of

279 Tissue resident memory T cells (Trm) form in the skin in vitiligo and pe

280 dence emphasizes the role of tissue-resident memory T cells (TRM) in the defense against recurring pa

281 tant in the establishment of tissue-resident memory T cells (Trm) in the lung tissue following influe

282 Numerous observations indicate that resident memory T cells (TRM) undergo unusually rapid attrition w

283 ffer cells (KCs) and CXCR3hi tissue-resident memory T cells (TRM).

284 adult mice, lung-localized, tissue-resident memory T cells (TRMs) mediate optimal protection to resp

285 of human resting naive, central and effector memory T cells using ChIP-Seq and found that unlike the

286 notypes of peanut-activated, CD154(+) CD4(+) memory T cells using fluorescence-activated cell sorting

287 frequency of Pf-specific polyfunctional CD4 memory T cells was associated with protection.

288 The tolerant state of the Helios-deficient memory T cells was not cell-intrinsic but was due to a s

289 Activated islet-specific CD8+ memory T cells were prevalent in subjects with T1D who e

290 of both effector memory T cells and central memory T cells were reduced, whereas naive T cells incre

291 ened activation of SMX-NO-specific naive and memory T cells, whereas blockade of TIM-3 produced no ef

292 onment and similarities with tissue-resident memory T cells, which are more radio-resistant than circ

293 SARS-CoV-2-specific memory T cells will likely prove critical for long-term

294 tients had higher percentages of CD4 and CD8 memory T cells with a concomitant decrease in frequency

295 responding donors have A68/NP(145)(+)CD8(+) memory T cells with clonally expanded TCRalphabetas, whi

296 6dimCD57+NKG2C+ NK cells are similar to CD8+ memory T cells with rapid and robust effector function u

297 n signals; and maintenance of differentiated memory T cells with survival factors.

298 pression of IFNG and IFNG-AS1 was evident in memory T cells, with high expression of this long non-co

299 ndent myeloma control, most efficiently from memory T cells within myeloma-experienced grafts, but al

300 sses many, though not all, features of "true memory" T cells, without the requirement of first encoun