ライフサイエンスコーパス: mental retardation

1 , aniridia, genitourinary malformations, and mental retardation).

2 r ataxia, hypotonia, oculomotor apraxia, and mental retardation.

3 can result in Phenylketonuria, a progressive mental retardation.

4 limb and craniofacial development as well as mental retardation.

5 chorioretinal dysplasia, microcephaly and/or mental retardation.

6 set limb-girdle muscular dystrophies without mental retardation.

7 leading cause of childhood hearing loss and mental retardation.

8 tations of PHF8 are associated with X-linked mental retardation.

9 e use disorders, hyperkinetic disorders, and mental retardation.

10 nine kinase, which is implicated in X-linked mental retardation.

11 e disorder characterized by skin defects and mental retardation.

12 rved in mouse models and human patients with mental retardation.

13 tatistically significantly increased risk of mental retardation.

14 Mutations in CASK cause X-linked mental retardation.

15 ssociated with cobblestone lissencephaly and mental retardation.

16 drome (FXS) is the leading form of inherited mental retardation.

17 ubiquitylase associated with human syndromic mental retardation.

18 n lead to cerebral palsy, hydrocephalus, and mental retardation.

19 and in Drosophila mutants null for fragile X mental retardation 1 (dfmr1), as well as following chann

20 s at the neuromuscular junction in fragile x mental retardation 1 (dfmr1)-deficient Drosophila, sugge

21 is typically caused by the loss of fragile X mental retardation 1 (FMR1) expression, which codes for

22 Silencing of fragile X mental retardation 1 (FMR1) gene and loss of fragile X m

23 00 CGG repeats; preCGG) within the fragile X mental retardation 1 (FMR1) gene can cause fragile X-ass

24 200 repeats; full mutation) in the fragile X mental retardation 1 (FMR1) gene cause fragile X syndrom

25 00 CGG repeats; preCGG) within the fragile X mental retardation 1 (FMR1) gene cause fragile X-associa

26 The human fragile X mental retardation 1 (FMR1) gene contains a (CGG)(n) tri

27 eat expansion in the 5'-UTR of the fragile X mental retardation 1 (FMR1) gene is known as a premutati

28 drome (FXS), caused by loss of the Fragile X Mental Retardation 1 (FMR1) gene product (FMRP), is the

29 e-repeat expansion adjacent to the fragile X mental retardation 1 (FMR1) gene promoter results in its

30 om a FXS mouse model affecting the fragile X mental retardation 1 (Fmr1) gene, resulting in decreased

31 t often caused by silencing of the fragile X mental retardation 1 (FMR1) gene.

32 ucleotide repeat expansions in the fragile X mental retardation 1 (FMR1) gene.

33 rriers (55-200 CGG repeats) of the fragile X mental retardation 1 (FMR1) gene.

34 abilities disrupted by loss of the Fragile X Mental Retardation 1 (Fmr1) gene.

35 GG-repeat expansion alleles of the fragile X mental retardation 1 (FMR1) gene; current evidence suppo

36 neurons (PNs) in the cerebellum of Fragile X Mental Retardation 1 (Fmr1) knockout (KO) mice, a model

37 aptic signaling impairments in the fragile X mental retardation 1 (Fmr1) knockout (KO) model of fragi

38 pocampal tissue from wide type and fragile X mental retardation 1 (Fmr1) knockout mice, we show that

39 The gene underlying the disorder, fragile X mental retardation 1 (FMR1), is silenced in most cases b

40 by the silencing of a single gene, fragile X mental retardation 1 (Fmr1).

41 FXR1 is an autosomal paralog of Fragile X mental retardation 1 and has not been directly linked to

42 the dendritic spine defects of the Fragile X Mental Retardation 1 gene KO neurons.

43 Finally, upregulating fragile X mental retardation 1 protein (Fmr1, also called FMRP) ac

44 nome segment upstream of the FMR1 (fragile X mental retardation 1) gene (Xq27.3) contains several gen

45 ecular analysis converged on FMR1 (Fragile X Mental Retardation 1), an important negative regulator o

46 e WAVE complex subunit cytoplasmic fragile X mental retardation 1-interacting protein 1 (Cyfip1).

47 due to silencing of the X-linked, fragile-X mental retardation-1 (FMR1) gene.

48 iated protein-like 2 (Cntnap2)(5), fragile X mental retardation-1 (Fmr1)(6) or Sh3 and multiple ankyr

49 X syndrome, the most common genetic form of mental retardation, a CGG trinucleotide-repeat expansion

50 ad of aniridia, genitourinary anomalies, and mental retardation, a subgroup of WAGR syndrome for Wilm

51 lson syndrome (MWS), characterized by severe mental retardation and agenesis of the corpus callosum.

52 nesis, and mutations of this protein lead to mental retardation and autism spectrum disorders.

53 tible to develop neurologic symptoms such as mental retardation and autism than mutation-positive pat

54 ficient in the most common inherited form of mental retardation and autism, fragile X syndrome (FXS).

55 me (FXS), the most common cause of inherited mental retardation and autism, is caused by transcriptio

56 opmental disorders including severe X-linked mental retardation and autism.

57 Given that Cullin4B mutations cause mental retardation and cerebral malformation, similar re

58 ovirus (CMV) infection is a leading cause of mental retardation and deafness in newborns.

59 ngenital CMV infection is a leading cause of mental retardation and deafness in newborns.

60 man X-linked genes have been associated with mental retardation and deficits in learning and memory.

61 of the leading prenatal causes of congenital mental retardation and deformities world-wide.

62 hich Notch dysregulation are associated with mental retardation and dementia are poorly understood.

63 Mental retardation and early Alzheimer's disease (AD) ha

64 re associated with a diverse set of X-linked mental retardation and epilepsy syndromes in humans.

65 rtical thinning as observed in some forms of mental retardation and fetal alcohol syndrome.

66 rtility and spontaneous abortions as well as mental retardation and inherited defects in their childr

67 enetic neurological disorder associated with mental retardation and intractable epilepsy, and Miller-

68 ions in their regulators are associated with mental retardation and other neurodevelopmental disorder

69 lative risks (RRs) for autistic disorder and mental retardation and rates per 100,000 person-years, c

70 ts support the mGluR hypothesis of fragile X mental retardation and suggest that deficient developmen

71 obesity, retinitis pigmentosa, polydactyly, mental retardation and susceptibility to cardiovascular

72 hich is the most prevalent form of inherited mental retardation and the primary monogenetic cause of

73 e pathological disorders, including X-linked mental retardation and tumorigenesis.

74 tor development (collectively abbreviated as mental retardation and/or disorders of psychological dev

75 disease causing homocystinuria, thrombosis, mental retardation, and a suite of other devastating man

76 risk of schizophrenia and related disorders, mental retardation, and autism spectrum disorders.

77 mental disorders (i.e., brain malformations, mental retardation, and autism).

78 The exclusion criteria included amblyopia, mental retardation, and concomitant ocular disease that

79 ATG5 in two siblings with congenital ataxia, mental retardation, and developmental delay.

80 the neurological disorder cerebellar ataxia, mental retardation, and disequilibrium (CAMRQ) syndrome,

81 the neurological disorder cerebellar ataxia, mental retardation, and disequilibrium (CAMRQ) syndrome.

82 R81, previously linked to cerebellar ataxia, mental retardation, and disequilibrium syndrome 2, cause

83 mutated in patients with cerebellar ataxia, mental retardation, and dysequilibrium syndrome.

84 in humans can lead to severe birth defects, mental retardation, and epilepsy.

85 e (FXS) is the most common form of inherited mental retardation, and it is caused by loss of function

86 sional seizures, one subject exhibiting mild mental retardation, and one subject exhibiting retinitis

87 family that suffers from cerebellar ataxia, mental retardation, and quadrupedal locomotion syndrome

88 Deafness, onychodystrophy, osteodystrophy, mental retardation, and seizures (DOORS) syndrome is a r

89 (deafness, onychodystrophy, osteodystrophy, mental retardation, and seizures), a condition that incl

90 at US$1 million per person and the costs of mental retardation are even higher.

91 f not treated promptly in infancy, can cause mental retardation, as the TH decrease results in improp

92 he creatine transporter SLC6A8, resulting in mental retardation associated with a complete absence of

93 osine kinase, have been observed in cases of mental retardation associated with developmental defects

94 osities are specifically linked to epilepsy, mental retardation, autism, schizophrenia and neuro-dege

95 The RNA-binding protein fragile-X mental retardation autosomal 1 (FXR1) is upregulated in

96 The expression levels of FXR1 (fragile X mental retardation autosomal homolog 1), an RNA-binding

97 Fragile-X mental retardation autosomal homologue-1 (FXR1) is a mus

98 .018), previously associated with autism and mental retardation but not SCZ.

99 (FXS) is the most common form of inheritable mental retardation caused by transcriptional silencing o

100 s chorioretinal dysplasia, microcephaly, and mental retardation (CDMMR).

101 increase in the RR for autistic disorder and mental retardation compared with IVF without ICSI.

102 (CCAL2), craniometaphyseal dysplasia (CMD), mental retardation, deafness and ankylosis syndrome (MRD

103 A21 gene overexpression are thought to cause mental retardation, dementia and seizure in this disorde

104 ation of PHF6, which results in the X-linked mental retardation disorder Borjeson-Forssman-Lehmann sy

105 developmental delay/intellectual disability/mental retardation, Down syndrome, cerebral palsy, autis

106 TASK3 (G236R) is responsible for Birk Barel mental retardation dysmorphism syndrome, a maternally tr

107 e to severe neurological anomalies including mental retardation, dystonia, chorea, pyramidal signs an

108 MEDNIK syndrome (mental retardation, enteropathy, deafness, peripheral ne

109 llele of 55-200 CGG repeats in the Fragile X mental retardation (FMR1) gene.

110 135.7 vs 29.3 per 100,000 person-years); for mental retardation following ICSI using surgically extra

111 nsion (>200 CGG repeats) in the fragile X mental retardation gene (FMR1), is currently not include

112 The patient, who features microcephaly and mental retardation, has reached adulthood without the ty

113 an result in permanent neurological defects, mental retardation, hearing loss, visual impairment, and

114 defect of exon inclusion and causes X-linked mental retardation Hedera type (MRXSH).

115 it has a regulatory loop with the fragile X mental retardation homologue FXR1 and regulates dopamine

116 leading to neurological disorders including mental retardation, hyperactivity, cognitive impairment,

117 re to thrive, seizures, developmental delay, mental retardation, hypotonia and sometimes with polycyt

118 etic disorder that leads to brain damage and mental retardation if untreated.

119 progressive disorder that results in severe mental retardation in early adulthood.

120 ves effective in reducing the risks of CP or mental retardation in ELGANs by 30%, we estimate an over

121 nd is the second most common cause of severe mental retardation in females, after Down syndrome.

122 drome (Rett) is the leading genetic cause of mental retardation in females.

123 ely molecular pathomechanism of epilepsy and mental retardation in humans.

124 rome, the most widespread inherited cause of mental retardation in humans.

125 e Phf21b locus associate with depression and mental retardation in humans.

126 rome, the most widespread inherited cause of mental retardation in humans.

127 9 (Pcdh19) cause female-limited epilepsy and mental retardation in humans.

128 SAP102 and PAKs are associated with X-linked mental retardation in humans; thus, synapse formation me

129 as, heart defects, ichthyosiform dermatosis, mental retardation (intellectual disability), and ear an

130 The second-largest cause of X-linked mental retardation is a deficiency in creatine transport

131 f HDAC4 encoded by an allele associated with mental retardation is a gain-of-function nuclear repress

132 e cerebral cortex, an important target since mental retardation is an important component of many of

133 umor, aniridia, genitourinary anomalies, and mental retardation) is a rare syndrome caused by a conti

134 syndrome, the most common form of heritable mental retardation, is a developmental disorder with kno

135 ome (FXS), the most common form of inherited mental retardation, is a neurodevelopmental disorder cau

136 agile X syndrome, a common form of inherited mental retardation, is caused by loss of the fragile X m

137 ome (FXS), the most common form of inherited mental retardation, is caused by silencing of the FMR1 g

138 ome (FXS), the most common form of inherited mental retardation, is caused by the loss of the Fmr1 ge

139 ome (FXS), the most common heritable form of mental retardation, is characterized by synaptic dysfunc

140 t multisystemic neuromuscular phenotype with mental retardation, leading to premature death at age 36

141 mbocytopenia, facial dysmorphism, growth and mental retardation, malformation of the heart and other

142 psychiatric disorder associated with autism, mental retardation, motor abnormalities, and epilepsy.

143 Often, ciliopathies are associated with mental retardation (MR) and malformation of the corpus c

144 road range of conditions, including profound mental retardation, obesity, metabolic disorders, and a

145 been recently implicated as risk factors for mental retardation or autism.

146 ere given a diagnosis of mild or unspecified mental retardation or disorders of psychological and mot

147 ly, studies have tentatively elucidated that mental retardation or physical stagnation deteriorates a

148 umber of neurologic diseases associated with mental retardation or/and dementia.

149 for impaired mental function in nonsyndromic mental retardation patients with CC2D1A mutation.

150 ty, eating disorders, personality disorders, mental retardation, pervasive developmental disorders, a

151 Here we identify Drosophila fragile X mental retardation protein (dFMRP) as a robust genetic m

152 inhibited the RNA-binding protein fragile X mental retardation protein (encoded by Fmr1), which cons

153 Fragile X mental retardation protein (FMRP) and Ataxin-2 (Atx2) ar

154 lay RNA-dependent interaction with fragile X mental retardation protein (FMRP) and bind to one anothe

155 iology associated with the loss of fragile X mental retardation protein (FMRP) and haploinsufficiency

156 cal region1 (DSCR1) interacts with Fragile X mental retardation protein (FMRP) and regulates both den

157 probability was reduced by loss of fragile X mental retardation protein (FMRP) and that FMRP acts on

158 and RNA binding proteins including Fragile X mental retardation protein (FMRP) and the related protei

159 Genes encoding the mRNA targets of fragile X mental retardation protein (FMRP) are enriched for genet

160 Fragile X mental retardation protein (FMRP) binds to and regulates

161 ardation 1 (FMR1) gene and loss of fragile X mental retardation protein (FMRP) cause fragile X syndro

162 memory indicating that the loss of fragile X mental retardation protein (FMRP) causes defects in epis

163 rstand how the loss of function of fragile X mental retardation protein (FMRP) causes fragile X syndr

164 The loss of fragile X mental retardation protein (FMRP) causes fragile X syndr

165 Loss of fragile X mental retardation protein (FMRP) causes fragile X syndr

166 Loss of the gene (Fmr1) encoding Fragile X mental retardation protein (FMRP) causes increased mRNA

167 ncing of the Fmr1 gene and loss of fragile X mental retardation protein (FMRP) expression.

168 NIFICANCE STATEMENT The absence of Fragile X Mental Retardation Protein (FMRP) from birth results in

169 To examine the role of the Fragile X mental retardation protein (FMRP) in altering CBF, we ex

170 How the loss of fragile X mental retardation protein (FMRP) in different brain cel

171 S) is caused by the absence of the Fragile X Mental Retardation Protein (FMRP) in neurons.

172 d is caused by a deficiency of the fragile X mental retardation protein (FMRP) in neurons.

173 Fragile X mental retardation protein (FMRP) is a multifunctional R

174 Fragile X Mental Retardation Protein (FMRP) is a regulatory RNA bi

175 The fragile X mental retardation protein (FMRP) is an mRNA binding pro

176 The Fragile X Mental Retardation Protein (FMRP) is an RNA binding prot

177 Fragile X mental retardation protein (FMRP) is an RNA-binding prot

178 Fragile X mental retardation protein (FMRP) is thought to regulate

179 n synthesis resulting from loss of fragile X mental retardation protein (FMRP) is thought to underlie

180 Fragile X mental retardation protein (FMRP) is well-studied, as it

181 fragile X syndrome, the absence of fragile X mental retardation protein (FMRP) leads to defects in pl

182 Loss of Fragile X mental retardation protein (FMRP) leads to Fragile X syn

183 Fragile X mental retardation protein (FMRP) loss causes Fragile X

184 we show that the effect of loss of fragile X mental retardation protein (FMRP) on these pathways is b

185 P = .0062) and for targets of the fragile X mental retardation protein (FMRP) pathway (10 observed v

186 mate receptor signaling though the fragile X mental retardation protein (FMRP) pathway may underlie s

187 The fragile X mental retardation protein (FMRP) plays an important rol

188 The tandem Agenet domain (TAD) of fragile X mental retardation protein (FMRP) protein is considered

189 Thus, the Fragile X Mental Retardation protein (FMRP) regulates expression o

190 The Fragile X mental retardation protein (FMRP) regulates neuronal RNA

191 Loss of function of the fragile X mental retardation protein (FMRP) results in defects in

192 Fragile X mental retardation protein (FMRP) sculpts synaptic refin

193 Whether fragile X mental retardation protein (FMRP) target mRNAs and neuro

194 Fmr1 encodes fragile X mental retardation protein (FMRP), a dendritic RNA bindi

195 e result of loss or dysfunction of fragile X mental retardation protein (FMRP), a highly selective RN

196 alizes to granules that label with fragile X mental retardation protein (FMRP), a transport granule c

197 By using the Fragile X Mental Retardation Protein (FMRP), an abundant neuronal

198 FXS is caused by the loss of fragile X mental retardation protein (FMRP), an mRNA binding prote

199 ment that results from the loss of fragile X mental retardation protein (FMRP), an mRNA binding prote

200 (FXS) is caused by the loss of the fragile X mental retardation protein (FMRP), an RNA binding protei

201 escribe here an essential role for fragile X mental retardation protein (FMRP), an RNA-binding protei

202 Fragile X mental retardation protein (FMRP), an RNA-binding protei

203 n in mouse neurons, which requires fragile X mental retardation protein (FMRP), an RNA-binding protei

204 More recently, fragile X mental retardation protein (FMRP), an RNA-binding protei

205 ealed reduced levels of endogenous fragile X mental retardation protein (FMRP), and a reporter contai

206 al leucine zipper kinase (DLK) and fragile X mental retardation protein (FMRP), control Dscam express

207 st because of its interaction with Fragile X mental retardation protein (FMRP), its upregulation in t

208 ing mRNAs that can be regulated by fragile X mental retardation protein (FMRP), some of which are dis

209 in translation and is dependent on fragile X mental retardation protein (FMRP), the protein that is d

210 Fragile X mental retardation protein (FMRP), the protein that is l

211 nts that affect genes regulated by Fragile-X mental retardation protein (FMRP), thought to play a key

212 ut impair rapid translation of the Fragile X mental retardation protein (FMRP), which is absent in Fr

213 sults from the loss of function of fragile X mental retardation protein (FMRP), which represses trans

214 FXS is caused by loss of the fragile X mental retardation protein (FMRP), which translationally

215 se to ethanol treatment, requiring fragile-X mental retardation protein (FMRP).

216 om the partial or complete loss of fragile X mental retardation protein (FMRP).

217 The process is antagonized by fragile X mental retardation protein (FMRP).

218 rolled by repressors including the fragile X mental retardation protein (FMRP).

219 o the absence of its gene product, fragile X mental retardation protein (FMRP).

220 caused by loss of function of the fragile X mental retardation protein (FMRP).

221 hannels (Ca(V)2.2) is regulated by fragile X mental retardation protein (FMRP).

222 hose messenger RNAs are targets of fragile X mental retardation protein (FMRP).

223 ardation, is caused by loss of the fragile X mental retardation protein (FMRP).

224 caused by the loss-of-function of fragile X mental retardation protein (FMRP).

225 1 gene resulting in the absence of fragile X mental retardation protein (FMRP).

226 ncodes the translational repressor fragile X mental retardation protein (FMRP).

227 a loss of the RNA-binding protein fragile X mental retardation protein (FMRP).

228 y and results from the loss of the fragile X mental retardation protein (FMRP).

229 g deficits, results from a loss of fragile X mental retardation protein (FMRP).

230 that disrupts the transcription of Fragile X Mental Retardation Protein (FMRP).

231 ) with abrogated expression of the Fragile X Mental Retardation Protein (FMRP).

232 er (ASD), results from the loss of Fragile X mental retardation protein (FMRP).

233 A-binding translational suppressor Fragile X Mental Retardation Protein (FMRP).

234 reports in autism, targets of the fragile X mental retardation protein (FMRP, product of FMR1) are e

235 Using male mice, we tested whether Fragile X Mental Retardation Protein (FMRPO), the protein whose ab

236 P=5.4 x 10(-4)) and targets of the Fragile X mental retardation protein (P=0.0018).

237 The resulting absence of fragile X mental retardation protein 1 (FMRP) leads to both pre- a

238 ASD-associated genes such as Fmr1 (fragile X mental retardation protein 1).

239 for LTH, these data indicate that fragile X mental retardation protein and Atx2 act via at least one

240 higher, more typical levels of the fragile X mental retardation protein and inversely correlated with

241 on protein synthesis controlled by fragile X mental retardation protein and on Arc signaling.

242 anslation-independent role for the fragile X mental retardation protein as a regulator of neural exci

243 Absence of fragile X mental retardation protein causes fragile X syndrome.

244 ssociated protein interactors, the fragile X mental retardation protein complex, voltage-gated calciu

245 disruptions of cytoplasmic CYFIP1-fragile X mental retardation protein complexes.

246 Fragile X mental retardation protein deletion in mice enhances met

247 sability, is caused by loss of the fragile X mental retardation protein FMRP.

248 escue mice, we further reveal that fragile X mental retardation protein function in amygdala inhibito

249 ranslation-independent function of fragile X mental retardation protein has a major role in regulatin

250 We identify a novel role for the fragile-X mental retardation protein in the posttranscriptional re

251 Loss of the Fragile X mental retardation protein leads to excessive excitatory

252 a physical interaction between the X-linked mental retardation protein oligophrenin-1 (OPHN1) and Ho

253 t hYVH1 co-localizes with YB-1 and fragile X mental retardation protein on stress granules in respons

254 These results suggest that Fragile X Mental Retardation Protein regulates dendritic HCN chann

255 naling and binding partners of the fragile X mental retardation protein).

256 l regulatory complex that includes fragile X mental retardation protein, DEAD box helicase 5, and the

257 involved in synaptic pruning, the fragile-X mental retardation protein, increases sleep intensity du

258 Y box-binding protein 1 (YB-1) and fragile X mental retardation protein, proteins that function in tr

259 ational control of target mRNAs of fragile X mental retardation protein, the gene product of Fmr1.

260 present study shows that replacing Fragile X Mental Retardation Protein, which is absent in Fragile X

261 e of autism, is due to loss of the fragile X mental retardation protein, which regulates signal trans

262 nriched in G-quadruplex motifs and fragile X mental retardation protein-associated RNAs and that enco

263 rects behavioural abnormalities in fragile X mental retardation protein-deficient mice.

264 hidonoyl-sn-glycerol, is absent in fragile X mental retardation protein-null mice.

265 the loss of the Fmr1 gene product, fragile X mental retardation protein.

266 f the FMR1 gene, which encodes the fragile X mental retardation protein.

267 al dynamics and interacts with the fragile X mental retardation protein.

268 al and child hypothyroidism may cause severe mental retardation, recent evidence suggests that milder

269 onstituents argonaute-2 (Ago2) and fragile X mental retardation-related protein 1 (FXR1) for translat

270 We identified fragile X mental retardation-related protein 1 (FXR1P), a RNA bind

271 Here, we show that the fragile X mental retardation-related protein 2 (FXR2P) cooperates

272 Down syndrome, the most prevalent cause of mental retardation, results from the presence of an extr

273 (deafness, onychodystrophy, osteodystrophy, mental retardation, seizures) to non-syndromic hearing l

274 different neuropathological symptoms such as mental retardation, seizures, and epilepsy.

275 kidney disease, genitourinary anomalies, and mental retardation, similar to the pathological defects

276 ams-Beuren syndrome is characterized by mild mental retardation, specific neurocognitive profile, hyp

277 ciated with wide-ranging symptoms, including mental retardation, speech and language impairment and o

278 15 synaptic proteins in normal and Fragile X mental retardation syndrome (FXS) model mouse cortex, an

279 domain-associated protein, alpha thalassemia/mental retardation syndrome X linked, switch/sucrose non

280 perone complex containing alpha-thalassaemia/mental retardation syndrome X-linked (ATRX) and death-do

281 Alpha thalassemia/mental retardation syndrome X-linked (ATRX) is a member

282 telomere binding proteins alpha thalassemia/mental retardation syndrome X-linked (ATRX) or death-dom

283 d that the ND10 component, alpha-thalassemia/mental retardation syndrome X-linked (ATRX) protein, is

284 Alpha thalassemia/mental retardation syndrome X-linked chromatin remodeler

285 FMRP, the disease gene product in fragile X mental retardation syndrome.

286 eafness, onychdystrophy, osteodystrophy, and mental retardation) syndrome, and identify endosome-to-l

287 spectrum of clinical outcomes, ranging from mental retardation to microcephaly, caused by congenital

288 tisystem genetic disease that manifests with mental retardation, tumor formation, autism, and epileps

289 ZMYM3 (zinc finger, myeloproliferative, and mental retardation-type 3) as a chromatin-interacting pr

290 h autism (MACROD2), development (NEDD4), and mental retardation (UBE2A) significantly associated with

291 a clinical diagnosis of autistic disorder or mental retardation until December 31, 2009.

292 rain, with clinical manifestations including mental retardation, vision impairment, and sensorineural

293 The RR for mental retardation was 1.18 (95% CI, 1.01-1.36; 46.3 vs

294 istic disorder and 180 of 15,830 (1.1%) with mental retardation were conceived by IVF.

295 ciated with juvenile or adolescent onset and mental retardation, whereas we show that the presence of

296 SI using frozen embryos were significant for mental retardation (with frozen embryos, RR, 2.36 [95% C

297 e the Arabidopsis thaliana Alpha Thalassemia-mental Retardation X-linked (ATRX) ortholog and show tha

298 onal inactivation of ATRX (alpha-thalassemia mental retardation X-linked) represents a defining molec

299 cannot overcome Daxx- and alpha-thalassemia mental retardation, X-linked (ATRX)-mediated transcripti

300 erminal deletions of ATRX (Alpha Thalassemia/Mental Retardation, X-linked) that generate in-frame fus