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1 o the topoisomerase inhibitors etoposide and merbarone.
2 aling may be involved in the cytotoxicity of merbarone.
3 CEM/M70-B cells might be similar to those of merbarone.
4 bilized by topo II inhibitors and blocked by merbarone.
5                                              Merbarone (5-[N-phenyl carboxamido]-2-thiobarbituric aci
6 ddress possible cellular mechanisms by which merbarone, a catalytic inhibitor of DNA topoisomerase II
7                     These data indicate that merbarone acts primarily by blocking topoisomerase II-me
8 tercalating agents etoposide, teniposide and merbarone, an effect that was maximal in the triple muta
9 sitive to other topoII catalytic inhibitors (merbarone and aclarubicin), as well as collaterally sens
10     These results suggest that resistance to merbarone and cross-resistance to etoposide might be thr
11 ontrast, there was a low correlation between merbarone and etoposide and between SN-38 and other topo
12 rategy to combine key structural elements of merbarone and etoposide and generated new type II topois
13 between etoposide and teniposide and between merbarone and SN-38.
14          These results provide evidence that merbarone can induce rapid disorganization of DNA in tum
15 ls with apoptosis-inducing concentrations of merbarone caused activation of c-Jun NH2-terminal kinase
16 cell lines are 3.5- to 6.6-fold resistant to merbarone, compared to the CEM parent cells.
17                                    Moreover, merbarone did not affect complex formation stabilized by
18                                     However, merbarone did not directly induce the excision of high m
19 ytic Topo II inhibitors such as ICRF-187 and merbarone do not do this.
20 ly to topoisomerase II), it is proposed that merbarone exerts its inhibitory effects through interact
21 ence of ATP), and the inhibitory profiles of merbarone for DNA cleavage and relaxation were similar.
22                                     Instead, merbarone induced rapid activation of the mitochondrial
23                                              Merbarone induced the release of high molecular weight D
24 6-dichlorobenzoyloxymethyl-ketone, inhibited merbarone-induced caspase-3/CPP32-like activity and apop
25           We find that caffeine can abrogate merbarone-induced G(2) arrest even in cells with functio
26                         Here, we report that merbarone induces programmed cell death or apoptosis in
27                                              Merbarone inhibited complex formation induced by etoposi
28                                              Merbarone inhibited DNA scission in a global (rather tha
29                                              Merbarone is a catalytic inhibitor of DNA topoisomerase
30                                              Merbarone is a catalytic inhibitor of topoisomerase II t
31 en partially elucidated, the cytotoxicity of merbarone is poorly understood.
32  that the catalytic inhibition of topo II by merbarone leads to apoptotic cell death through a caspas
33 hypothesized that pretreatment of cells with merbarone or aclarubicin, known catalytic inhibitors of
34  or -sensitive cells with equitoxic doses of merbarone or teniposide results in a G(2)/M arrest.
35 cross-resistance to SN-38 might be through a merbarone-related mechanism.
36 To investigate this issue, we established 12 merbarone-resistant cell lines from human leukemia CEM c
37 mmon, indicating a common origin, two of the merbarone-resistant lines (B1 and B8) each had unique st
38                            Concentrations of merbarone that inhibited catalytic activity >/=80% had n
39 IIalpha may play a role in the resistance to merbarone that is different from that to complex-stabili
40 chanistic basis for the inhibitory action of merbarone, the effects of this drug on individual steps
41 lar weight DNA was inhibited at least 80% in merbarone-treated cells preincubated with the pan-caspas
42 , using CEM cells selected for resistance to merbarone, we found that topo IIalpha RNA levels were re
43 ive inhibitors of TopoIIalpha, etoposide and merbarone, were ineffective at preventing TopoIIalpha-de
44 key pharmacophoric elements of etoposide and merbarone, which are two well-known topoII blockers.
45          Inhibition of topoisomerase II with merbarone, which does not stabilize a cleavage complex,