ライフサイエンスコーパス: messenger ribonucleoprotein

1 e of the RNA-binding protein FMRP (fragile X messenger ribonucleoprotein).

2 ponse to an increase in untranslating mRNPs (messenger ribonucleoproteins).

3 ation, and translational regulation of these messenger ribonucleoproteins.

4 Mutations in the Fragile X Messenger Ribonucleoprotein 1 (FMR1) gene are linked to

5 ' untranslated region (UTR) of the fragile X messenger ribonucleoprotein 1 (FMR1) gene on the X chrom

6 y transcriptional silencing of the fragile X messenger ribonucleoprotein 1 (FMR1) gene.

7 sleep deficits in mice lacking the Fragile X messenger ribonucleoprotein 1 (FMR1) gene.

8 ental disorder caused by silencing Fragile X messenger ribonucleoprotein 1 (Fmr1), which encodes the

9 Finally, the absence of fragile X messenger ribonucleoprotein 1 (FMRP) led to impaired lon

10 Fragile X messenger ribonucleoprotein 1 protein (FMRP) binds many

11 Fragile X messenger ribonucleoprotein 1 protein (FMRP) deficiency

12 Surprisingly, the FMR1 (Fragile X Messenger Ribonucleoprotein 1) gene is transcribed in >7

13 We also discuss the properties of messenger ribonucleoprotein and higher order RNA granule

14 anules (SGs) harbour translationally stalled messenger ribonucleoproteins and play important roles in

15 anslation reaction FMRP interacts with other messenger ribonucleoproteins and pre-exposure of FMRP to

16 t microtubule-dependent trafficking of mRNP (messenger ribonucleoprotein) and localized protein trans

17 RNA hairpin-tagged mRNAs for purification of messenger ribonucleoproteins assembled on transcripts wi

18 n, rewiring metabolism and forming transient messenger ribonucleoprotein assemblies called stress gra

19 The protein kinase mTOR activates canonical messenger ribonucleoproteins by post-translationally dow

20 erent pre-mRNAs, generating a "splicing" or "messenger ribonucleoprotein code" that determines exon r

21 sults suggest that Tpa1p is a component of a messenger ribonucleoprotein complex bound to the 3' untr

22 e DEAD-box protein Dbp5, promoting localized messenger ribonucleoprotein complex remodeling, and ensu

23 ved cytoplasmic aggregates of nontranslating messenger ribonucleoprotein complexes (mRNPs) implicated

24 ATPases, and the complete structures of some messenger ribonucleoprotein complexes (mRNPs) remain unc

25 ify subsets of mRNAs contained in endogenous messenger ribonucleoprotein complexes (mRNPs) that are c

26 (SGs) are cytoplasmic condensates of stalled messenger ribonucleoprotein complexes (mRNPs) that form

27 sembly, localization, or stability of axonal messenger ribonucleoprotein complexes (mRNPs).

28 ntracellular transport of cargoes, including messenger ribonucleoprotein complexes (RNPs).

29 e movement of both membranous organelles and messenger ribonucleoprotein complexes by dynein and kine

30 main of NFAR2 was required to associate with messenger ribonucleoprotein complexes containing RNG105/

31 ted by immunoprecipitation of HuR-containing messenger ribonucleoprotein complexes followed by real-t

32 ng small GTPase Rac1 was present in the Fmr1-messenger ribonucleoprotein complexes in vivo.

33 with high affinity, and it is a component of messenger ribonucleoprotein complexes in vivo.

34 ther proteins play a part in the assembly of messenger ribonucleoprotein complexes into transport gra

35 RNA granules are large messenger ribonucleoprotein complexes that regulate tran

36 cis-localization (zipcode) elements to form messenger ribonucleoprotein complexes, which then transp

37 eta, was not found in the immunoprecipitated messenger ribonucleoprotein complexes.

38 Loss of fragile X messenger ribonucleoprotein (FMRP) causes fragile X synd

39 Loss of fragile X messenger ribonucleoprotein (FMRP) causes fragile X synd

40 Here, we investigate how Fragile X Messenger Ribonucleoprotein (FMRP) deficiency disrupts s

41 Fragile X messenger ribonucleoprotein (FMRP) is a critical regulat

42 Mutations in, or deficiency of, fragile X messenger ribonucleoprotein (FMRP) is responsible for th

43 rome (FXS) arises from the loss of fragile X messenger ribonucleoprotein (FMRP) needed for normal neu

44 lasticity and contains presynaptic fragile X messenger ribonucleoprotein (FMRP), an RNA-binding prote

45 pmental disorder caused by loss of Fragile X messenger ribonucleoprotein (FMRP).

46 Cul4B licenses the TTP-containing TNF-alpha messenger ribonucleoprotein for loading onto polysomes,

47 that these proteins can also participate in messenger ribonucleoprotein formation in living cells.

48 tein and Actg1 transcript are colocalized in messenger ribonucleoprotein granules responsible for the

49 quid-liquid phase separation (LLPS) to merge messenger ribonucleoprotein granules with the translatio

50 onsive transcription factors and cytoplasmic messenger ribonucleoprotein granules.

51 This messenger ribonucleoprotein has been called the pioneer

52 s of the RNA-binding protein FMRP (fragile X messenger ribonucleoprotein) have been linked to schizop

53 ut not c-myc and beta-actin mRNAs in vivo by messenger ribonucleoprotein immunoprecipitation analyses

54 ut how mRNAs stored as translationally inert messenger ribonucleoproteins in developing spermatids be

55 ng that NCBP1 and RHA both are components of messenger ribonucleoproteins in several cell types.

56 ut also results in remodeling of the spliced messenger ribonucleoprotein, influencing various downstr

57 and reduction of Cul4B expression shunts the messenger ribonucleoproteins into the degradative pathwa

58 EX) complex plays central roles during mRNP (messenger ribonucleoprotein) maturation and export from

59 Stress granules are large messenger ribonucleoprotein (mRNP) aggregates composed o

60 translating polyribosomes as part of a large messenger ribonucleoprotein (mRNP) and modulates the tra

61 In vitro messenger ribonucleoprotein (mRNP) assembly assays demon

62 We provide a model whereby messenger ribonucleoprotein (mRNP) assembly requires Dbp

63 t represent a specific biological program of messenger ribonucleoprotein (mRNP) assembly, but instead

64 ins and how they determine directionality of messenger ribonucleoprotein (mRNP) complex export from t

65 dentified a cytoplasm-restricted beta-globin messenger ribonucleoprotein (mRNP) complex in both cultu

66 selective RNA-binding protein which forms a messenger ribonucleoprotein (mRNP) complex that associat

67 associated with the in vivo configured FMRP messenger ribonucleoprotein (mRNP) complex.

68 roteins multiplex in trans, forming discrete messenger ribonucleoprotein (mRNP) complexes (called tra

69 or the integrity and function of cytoplasmic messenger ribonucleoprotein (mRNP) complexes called stre

70 To isolate its in vivo targets, messenger ribonucleoprotein (mRNP) complexes containing

71 In vitro reconstitution of messenger ribonucleoprotein (mRNP) complexes demonstrate

72 ed SR proteins remain stably associated with messenger ribonucleoprotein (mRNP) complexes during expo

73 st mRNA export factor Yralp, is recruited to messenger ribonucleoprotein (mRNP) complexes generated b

74 t selectively binds a subset of mRNAs, forms messenger ribonucleoprotein (mRNP) complexes, and associ

75 Cellular mRNAs exist in messenger ribonucleoprotein (mRNP) complexes, which unde

76 nt mechanisms within viral protease-modified messenger ribonucleoprotein (mRNP) complexes.

77 activated C kinase, RACK1, is a component of messenger ribonucleoprotein (mRNP) complexes.

78 A-binding protein, works with other cellular messenger ribonucleoprotein (mRNP) components to ensure

79 Stress-induced messenger ribonucleoprotein (mRNP) condensation is conse

80 fundamental cellular processes by regulating messenger ribonucleoprotein (mRNP) dynamics.

81 ound to present similarities with eukaryotic messenger ribonucleoprotein (mRNP) granules, membraneles

82 By use of messenger ribonucleoprotein (mRNP) immunopurification, w

83 s that recognizes and routes mRNAs through a messenger ribonucleoprotein (mRNP) network.

84 complement of proteins, the exact nature of messenger ribonucleoprotein (mRNP) packaging and its fun

85 lymerase II (RNAPII), it is assembled into a messenger ribonucleoprotein (mRNP) particle; this is the

86 Processing and packaging of messenger ribonucleoprotein (mRNP) particles involve com

87 elicase Xp54 is an integral component of the messenger ribonucleoprotein (mRNP) particles of Xenopus

88 of Xp54, an integral component of the stored messenger ribonucleoprotein (mRNP) particles, can rescue

89 his time a large amount of mRNA is stored as messenger ribonucleoprotein (mRNP) particles.

90 plasmic mRNA export factor docking sites and messenger ribonucleoprotein (mRNP) remodeling machinery

91 pic assemblies is an inherent property of an messenger ribonucleoprotein (mRNP) that is augmented und

92 e the assembly and activation of a decapping messenger ribonucleoprotein (mRNP) that promotes 5'-3' m

93 nd SmD3 are specific components of the oskar messenger ribonucleoprotein (mRNP), proper localization

94 oocyte maturation and are present in a c-mos messenger ribonucleoprotein (mRNP).

95 eceptor NXF1 (Mex67 in yeast) assembles with messenger ribonucleoproteins (mRNP) in the nucleus and g

96 egulatory factors are mRNA-binding proteins (messenger ribonucleoprotein, mRNP), which control the fa

97 odies (PBs) contain translationally silenced messenger ribonucleoproteins (mRNPs) and serve as extens

98 NA export receptor serving as a link between messenger ribonucleoproteins (mRNPs) and the nuclear por

99 s topoisomerase was a component of cytosolic messenger ribonucleoproteins (mRNPs) and was catalytical

100 d a novel paradigm for how newly synthesized messenger ribonucleoproteins (mRNPs) are matured.

101 At the NPC, messenger ribonucleoproteins (mRNPs) first encounter the

102 ent proteins and image translation of single messenger ribonucleoproteins (mRNPs) in human cells.

103 and proteins that assemble into specialized messenger ribonucleoproteins (mRNPs) localized in the ge

104 Bulk nuclear export of messenger ribonucleoproteins (mRNPs) through nuclear por

105 ctors, the proteasome, and key components of messenger ribonucleoproteins (mRNPs).

106 w that peripherin mRNA-containing particles (messenger ribonucleoproteins [mRNPs]) move mainly along

107 able messenger RNA (mRNA) protein complexes (messenger ribonucleoproteins [mRNPs]).

108 We recently reported that spliceosomes alter messenger ribonucleoprotein particle (mRNP) composition

109 s efficient and ordered assembly of a mature messenger ribonucleoprotein particle (mRNP).

110 show that SLBP is a component of the histone messenger ribonucleoprotein particle (mRNP).

111 t) complex physically couples transcription, messenger ribonucleoprotein particle biogenesis, RNA pro

112 s-acting factors that are present in the VSG messenger ribonucleoprotein particle, and mechanisticall

113 al in sequence, are assembled into different messenger ribonucleoprotein particles (mRNP) in vitro.

114 d may bridge the transition between exported messenger ribonucleoprotein particles (mRNPs) and polyso

115 c transport of two types of cargos, zipcoded messenger ribonucleoprotein particles (mRNPs) and tubula

116 at lead to the formation of export-competent messenger ribonucleoprotein particles (mRNPs) are under

117 ntial role in the irreversible remodeling of messenger ribonucleoprotein particles (mRNPs) as they ex

118 les formed upon increases in non-translating messenger ribonucleoprotein particles (mRNPs) during str

119 p50, the major core protein of messenger ribonucleoprotein particles (mRNPs) in the cyt

120 transcrptionally processed and packaged into messenger ribonucleoprotein particles (mRNPs) in the nuc

121 Nuclear export of mRNAs in the form of messenger ribonucleoprotein particles (mRNPs) is an obli

122 maternal mRNAs are packaged by protein into messenger ribonucleoprotein particles (mRNPs) that are m

123 mitigated by the ability to form closed-loop messenger ribonucleoprotein particles (mRNPs) via eIF4F-

124 s in mRNA export are the nuclear assembly of messenger ribonucleoprotein particles (mRNPs), the trans

125 ocess, involving the packaging of mRNAs into messenger ribonucleoprotein particles (mRNPs), their tra

126 ated, they are clothed with proteins to form messenger ribonucleoprotein particles (mRNPs), which are

127 rs bind the mRNA in large complexes known as messenger ribonucleoprotein particles (mRNPs).

128 s is preceded by the nuclear assembly of pre-messenger ribonucleoprotein particles (mRNPs).

129 omolecules such as transcription factors and messenger ribonucleoprotein particles across the NE.

130 ate the formation of mature export-competent messenger ribonucleoprotein particles and to prevent the

131 It is a major component of free messenger ribonucleoprotein particles and, at higher con

132 ng machinery, is an important constituent of messenger ribonucleoprotein particles because it partici

133 Following maturation of messenger ribonucleoprotein particles during and after t

134 sed by decreased expression of the fragile X messenger ribonucleoprotein protein (FMRP), a ribosomal-

135 ins onto mRNA suggests a role for the EJC in messenger ribonucleoprotein remodeling involving interac

136 n depletion does not trigger the assembly of messenger ribonucleoprotein stress granules, which typic

137 , loss-of-function constraint, and fragile X messenger ribonucleoprotein target gene sets.

138 Here, we characterize the nature of messenger ribonucleoprotein that is targeted for NMD in

139 ength FMR1 RNA, and restores FMRP (Fragile X Messenger RibonucleoProtein) to normal levels.