ライフサイエンスコーパス: metabolic

1 xO3a/AMPK/PPAR-alpha signaling and rectifies metabolic abnormalities.

2 ences, is characterized by hyperglycemia and metabolic acidosis due to the accumulation of ketone bod

3 ored reactive oxygen species homeostasis and metabolic activities involving lipid metabolism, specifi

4 ored the impact of gold nanoparticles on the metabolic activity and morphology of human pulmonary end

5 Thus TLG, commonly considered a measure of metabolic activity in tumors, is also in this cohort a m

6 n of endothelial metabolism by GW0742, where metabolic activity is reduced in monolayers but enhanced

7 acteristics can support the islet viability, metabolic activity, and dose necessary to reverse diabet

8 ells with integrated fluorescence readout of metabolic activity.

9 rent nanoparticles modestly affects cellular metabolic activity.

10 of NBD-Bu for detection of abnormal cellular metabolic activity.

11 te glucagon-mediated responses and efficient metabolic adaptation to fasting in vivo.

12 es suggested impaired axonal myelination and metabolic adaptation to neuronal degeneration.

13 Metabolic adaptation was defined as a significantly diff

14 sm in a manner that reverses the deleterious metabolic adaptations of the failing heart.

15 ulin resistance are evolutionarily conserved metabolic adaptations to severe injury including major t

16 the context of evolution, cell biology, and metabolic adaptations.

17 ent of aerobic glycolysis, a near ubiquitous metabolic alteration in cancer.

18 Finally, microscopy-based metabolic analysis revealed that migratory cells selecti

19 calating problem of obesity and its multiple metabolic and cardiovascular complications threatens the

20 be generally protected from obesity-induced metabolic and cardiovascular complications.

21 Our data will help both to dissect the metabolic and developmental triggers for bolting and to

22 ablish direct pathways for cells to transfer metabolic and electrical messages.

23 r, these findings decipher a proinflammatory metabolic and epigenetic reprogramming of macrophages in

24 reasons, detailed studies pertaining to the metabolic and gene regulatory networks operating in the

25 thermore, numerous infectious, inflammatory, metabolic and genetic diseases, as well as alcohol abuse

26 atients with lean NAFLD had a more favorable metabolic and histological profile compared with those w

27 A complex interplay of metabolic and immunological mechanisms underlies many di

28 of a plethora of chronic diseases including metabolic and inflammatory disorders and tumorigenesis.

29 h pathologies such as degenerative diseases, metabolic and inflammatory disorders, and cancer.

30 its peptides have been associated with many metabolic and neurological disorders.

31 opportunities to probe the genetic basis of metabolic and phenotypic variation, providing insight in

32 erse outcome pathway, where the oxidation of metabolic and regulatory Fe-S centers of proteins by LCO

33 to the 24-hour circadian clock to coordinate metabolic and stress rhythms.

34 ntly hosts 298 reference pathways, including metabolic and transport pathways, transcriptional networ

35 Furthermore, the molecular, metabolic, and clinical profile of patients with reduced

36 haracterized by structural, gene expression, metabolic, and functional specializations in cardiomyocy

37 t restful sleep and contribute to cognitive, metabolic, and physiologic dysfunction [1, 2].

38 our bodies and are essential in protective, metabolic, and physiologic functions of human health.

39 y, spectroscopy and DTI captured functional, metabolic, and structural changes in key regions of the

40 Here we develop a consistent metabolic approach that combines two complementary carbo

41 rsens cancer outcomes and may point to a new metabolic approach to treating some cancers.

42 nergy sensor AMPK is necessary to offset the metabolic burden of overnutrition was tested using chow-

43 f aquatic ectotherms and may place a greater metabolic burden on larger individuals, impairing their

44 series of genetic deletions in an apicoplast metabolic bypass line to determine which genes involved

45 Resulting patchwork may give rise to unique metabolic capabilities; on the other hand, it can also b

46 ess the microbial community compositions and metabolic capacity, and to identify genes involved in li

47 ical provider types of the multidisciplinary metabolic center from the pre-telehealth, post-telehealt

48 Further characterization of metabolic changes after INSTI initiation and potential t

49 The required metabolic changes are also no less complex than those ob

50 e damage compared with healthy controls, and metabolic changes associate with susceptibility to CDI.

51 umor with a silent genome, is dependent upon metabolic changes associated with hypoxia that drive the

52 re implanted to determine cardiovascular and metabolic changes during uterine handling.

53 Global metabolic changes were driven by both N speciation and d

54 sease, which shares similar pathological and metabolic changes with GSD Ia.

55 n the setting of human health, understanding metabolic changes within bacteria in environments where

56 2) causes insulin resistance, and 3) reduces metabolic clearance rate of insulin.

57 disease (NAFLD) is associated with incident metabolic complications.

58 tween two samples may not reflect their real metabolic concentration ratios (i.e., fold-change compre

59 is while suppressing plant defenses, but the metabolic connections and requirements involved are larg

60 on of subtle, but physiologically important, metabolic consequences of sub-optimal (functional) vitam

61 However, metabolic constraints imposed by the tumor microenvironm

62 thms of nutrient intake, energy balance, and metabolic control remain poorly defined.

63 A network community analysis of high metabolic cooperation but low competition reveals distin

64 ge and information transmission and minimize metabolic cost.

65 Here we demonstrate metabolic coupling in a remarkable, rapid adaptation pro

66 The in-vivo metabolic data were validated by mitochondrial respirome

67 for zooplankton at a time of year when their metabolic demand is highest.

68 Interestingly, ILC2(10)s demonstrated a metabolic dependency on the glycolytic pathway for IL-10

69 We hypothesize that metabolic derangement due to advanced shock in criticall

70 Seven patients experienced significant metabolic derangements, hypoxemia, or exposure to sedati

71 rget genes and McrA governs the cellular and metabolic development in Aspergillus nidulans.

72 s 2 (SARS-CoV-2) and an existing pandemic of metabolic disease driven by obesity.

73 idney disease, obstructive sleep apnoea, and metabolic disease including diabetes and obesity.

74 is may be a potential therapeutic target for metabolic disease intervention.

75 Several metabolic disease models have shown that dysregulation o

76 The metabolic disease type 2 diabetes (T2D) is a risk factor

77 ding new insight into the pathophysiology of metabolic disease.

78 rrelate with cardiovascular risk factors and metabolic disease.

79 tress in the nutritional programming of this metabolic disease.

80 ) gene to be associated with reduced risk of metabolic diseases (hypertriglyceridemia, obesity, type

81 nd their dysfunctions, which lead to several metabolic diseases including obesity or type 2 diabetes.

82 ffected by acquired autoimmune disorders and metabolic diseases such as diabetes mellitus.

83 lin resistance being a major risk factor for metabolic diseases such as type 2 diabetes.

84 bute to their increased risk for adult onset metabolic diseases, such as diabetes and obesity.

85 ns with chronic infectious, inflammatory, or metabolic diseases.

86 t decision in cardiovascular, pulmonary, and metabolic diseases.

87 ith an increased risk of obesity and related metabolic disorders, but the role of sleep in long-term

88 ion of acylcarnitines (ACs), often caused by metabolic disorders, has been associated with obesity, a

89 two essential organelles are associated with metabolic disorders, neurodegenerative diseases, and agi

90 promising approach for targeting cancer and metabolic disorders.

91 spersal had lower soil microbial biomass and metabolic diversity but higher bacterial and fungal spec

92 kuranetin accumulation, indicating that this metabolic diversity predates rice domestication.

93 Metabolic dysfunction of the liver, as an intermediate o

94 Adipose tissue metabolic dysfunction, including fibrosis, plays a centr

95 ension may synergistically induce macrophage metabolic dysfunction, particularly during cardiac remod

96 Ca(mito) may be a new approach to ameliorate metabolic dysregulation in heart failure.

97 oth tissue homeostasis in the lean state and metabolic dysregulation in obesity.

98 the hypoxia signaling pathway, resulting in metabolic dysregulation, heightened angiogenesis, intrat

99 espond to changes by inherently compromising metabolic efficiency.

100 CYP2B6 is a vital enzyme for the metabolic elimination of xenobiotics, and it is prone to

101 s for the production of bulk chemicals via a metabolic engineering approach it is necessary to better

102 tion in pure form, highlighting the need for metabolic engineering approaches for high-level Taxol pr

103 including enzymatic assays, mutant analysis, metabolic engineering, isotope labeling and metabolic pr

104 Magnetic beads coated with metabolic enzymes were used to make potentially reactive

105 rafish harbor a full complement of cobalamin metabolic enzymes, we used genome editing to study the l

106 , 0.80), lower physical activity (MD = -1.41 metabolic equivalent of task-hours/week, 95% CI: -2.07,

107 ved a lower maximal workload (PEX group, 8.2 metabolic equivalents +/- 1.7; control group, 11.8 metab

108 lic equivalents +/- 1.7; control group, 11.8 metabolic equivalents +/- 5.5; P < .0001).

109 Model simulations reveae metabolic exchanges that sustain the heterotrophs in min

110 s a risk factor for CVD independent of major metabolic factors.

111 r ESI response, signal intensity ratios of a metabolic feature calculated between two samples may not

112 , which demonstrated high performance of the metabolic fingerprinting and revealed the presence of me

113 llular compartments provides plants with the metabolic flexibility to maintain physiological levels o

114 Metabolic flexibility was defined as the change in 24-h

115 Metabolic flux analysis (MFA) is highly relevant to unde

116 be added to and integrated into the existing metabolic framework.

117 BACKGROUNDInsulin is a key regulator of metabolic function.

118 e identified specific gut bacteria and their metabolic functions associated with EAE susceptibility,

119 ses show that alpha2-Na/K ATPase loss alters metabolic gene expression with consequent serine and gly

120 However, it is unclear to what extent metabolic health changes over time and whether such tran

121 Effects of resveratrol on metabolic health have been studied in several short-term

122 Our data further suggest that metabolic health is a transient state for a large propor

123 We aimed to examine the association of metabolic health status and its transition with risks of

124 e and composition are affected by changes in metabolic health, and vice versa.

125 strained by empirical blood perfusion rates, metabolic heat generation rates reached as high as 2.0E0

126 Biotrophic growth requires maintaining metabolic homeostasis while suppressing plant defenses,

127 ory Fe-S centers of proteins by LCO disrupts metabolic homeostasis, which negatively impacts the grow

128 irculation of bile acids can greatly disrupt metabolic homeostasis.

129 n GLP-1 secretion in the maintenance of 24-h metabolic homeostasis.

130 This mechanism generates a metabolic homeostatic circuit that protects cells from b

131 Changes in the levels of metabolic hormones (glucocorticoids) in response to vari

132 Metabolic hyperactivity of plasmablasts resulted in nutr

133 1% for only ctDNA detection and 57% for only metabolic imaging analysis (P < .001 for comparison of e

134 otherapy without surgery, combined ctDNA and metabolic imaging analysis predicted progression in 100%

135 We investigated the metabolic impact in the NAc of antidepressant LAC treatm

136 he deposition of extracellular matrix - have metabolic implications.

137 hway for tryptophan degradation, an unstable metabolic intermediate, alpha-amino-beta-carboxymuconate

138 eroprotective intervention, and uncovers how metabolic intervention can act upon the immune system to

139 The metabolic kinetic changes revealed the alteration of met

140 Using metabolic labeling and pulse-chase analysis of HIV-1 Gag

141 , a protein-protein interaction layer, and a metabolic layer.

142 ta are mediated, at least in part, through a metabolic maladaptation in glutamine metabolism and how

143 Metabolic manipulations that increased mitochondrial red

144 atory and subsequent changes in BW, BF%, and metabolic markers as response variables.

145 intain physiological levels of acetate and a metabolic mechanism for the recovery of carbon that woul

146 Together, our findings define a metabolic mechanism regulated by astrocytic alpha2-Na/K

147 Thus, we demonstrate a non-cell-autonomous metabolic mechanism that controls the fate of injured ax

148 is (MFA) is highly relevant to understanding metabolic mechanisms of various biological processes.

149 M is immune mediated and T2DM is mediated by metabolic mechanisms.

150 We use metabolic modeling to predict basal ROS production level

151 Metabolic-modeling, using a novel model for MG1655 and c

152 Metabolic modelling has the potential to provide insight

153 ave now highlighted the potential for ketone metabolic modulation as a promising treatment paradigm.

154 eutics that decrease the risk of autoimmune, metabolic, neoplastic, and infectious diseases of the in

155 nts are important in providing the necessary metabolic network activity.

156 e main computational approach for predicting metabolic network fluxes, flux balance analysis, often u

157 introduces a second catalytic cycle into the metabolic network, was used to close the first cycle.

158 e ito977 model of Saccharomyces cerevisiae's metabolic network.

159 Unable to generate new enzyme paradigms and metabolic networks de novo, organisms have evolved strat

160 nsion over available reconstructed bacterial metabolic networks.

161 multiple taxa that occupy the same apparent metabolic niche when the system is viewed in bulk.

162 n of PhotoPPI profiles in cells experiencing metabolic or redox stress confirmed that KEAP1 sheds man

163 mice develop perivascular fibrosis in major metabolic organs, including the adipose tissue, skeletal

164 The data indicate that metabolic oscillations in acetogen gas fermentation are

165 Small differences in metabolic outcomes were apparent in participants followi

166 nsr signaling in T regs leads to undesirable metabolic outcomes.

167 is C virus (HCV) results in rapid changes in metabolic parameters early in direct-acting antiviral (D

168 r, increasing dietary nervonic acid improves metabolic parameters in mice fed a high fat diet.

169 We compared metabolic parameters of skeletal muscle from global Zip1

170 duces lifespan and causes local and systemic metabolic pathology.

171 number of genetic factors are related to the metabolic pathway of benzopyrene, a main compound in cig

172 activates a nuclear factor kappa B-dependent metabolic pathway, leading to aerobic glycolysis and pol

173 dis, S capitis, S aureus), and enrichment in metabolic pathways (eg, branched chain amino acids and a

174 tic conditions that can disrupt intermediary metabolic pathways and cause defective absorption and me

175 ify differentially expressed metabolites and metabolic pathways associated with neuropathology and co

176 niques to map the complex and interconnected metabolic pathways of the heart; however, normalization

177 e-and its key role in the regulation of cell metabolic pathways that underly normal human T cell resp

178 pportunities to reshape the TME by targeting metabolic pathways to favor immunity.

179 magnitude of the contribution of identified metabolic pathways to fitness in different community con

180 Thus, primordial metabolic pathways, already present in bacteria before a

181 al of S. aureus mutants deficient in central metabolic pathways, including glycolysis, gluconeogenesi

182 and the possible interplay between the 2 Trp metabolic pathways.

183 ce proteins, transcriptional regulators, and metabolic pathways.

184 Here, we conduct machine learning of serum metabolic patterns to detect early-stage LA.

185 f research on innate immunity in obesity and metabolic perturbation, as well as future directions.

186 The metabolic perturbations corroborate the observed physiol

187 if dietary nervonic acid content alters the metabolic phenotype in mice fed a high fat diet.

188 -mediated mechanisms underlying the observed metabolic phenotype of EC-AGO1-KO.

189 al presentations and identify possible brain metabolic phenotypes of this syndrome.

190 sfunction, cancer cells manifest overlapping metabolic phenotypes, suggesting that they may be target

191 high-fat high-sucrose diet and profiled the metabolic phenotypes.

192 that dynamic regulation of ion transport and metabolic plasticity are required to maintain osmotic an

193 e first time that eosinophils are capable of metabolic plasticity, evidenced by increased glucose-der

194 Here, we hypothesized that minimization of metabolic power could drive people to walk asymmetricall

195 ed by NMR metabolomics to highlight specific metabolic processes and to monitor pathway flux.

196 Metabolic processes occurring during host-microbiota-pat

197 ing, and thereby mediating developmental and metabolic processes related to nitrogen use.

198 hat span from regulation of transcription to metabolic processes that contribute to aberrant cell pro

199 ssDNA-binding protein, is essential for all metabolic processes that involve ssDNA, including DNA re

200 imes and unscheduled snacking disrupts timed metabolic processes, which further contribute to weight

201 , regulation of humoral response and various metabolic processes.

202 (SPME) method capable of analyzing drugs and metabolic products in biofluids and living tissues holds

203 of the role of bacteria and fungi and their metabolic products on disease suppression with the addit

204 to enumerate bacterial populations and their metabolic products should provide much needed clarity.

205 and results in a significant decrease in its metabolic products.

206 ssue, the transgenic mice showed a healthier metabolic profile, including ameliorated fibrosis and in

207 e latter is key for a reliable comparison of metabolic profiles and for unknown biomarker identificat

208 applied to the modeling of individual cancer metabolic profiles of hundreds to thousands of samples i

209 2D NMR spectroscopy was used for unambiguous metabolic profiling of albedo, flavedo and juice samples

210 metabolic engineering, isotope labeling and metabolic profiling to capture PFCs and demonstrate thei

211 sette (ABC) transporters, and central carbon metabolic proteins) were positively correlated with acyl

212 hat connects cell size to the inverse of the metabolic proteome mass fraction and the active fraction

213 n of the drug-exposed population enters into metabolic quiescence (dormancy) as persister forms.

214 sting-induced state with a greatly decreased metabolic rate and a body temperature as low as 20 degre

215 emperate latitudes is associated with slower metabolic rate remains unclear.

216 The scaling exponents of whole-plant metabolic rate vs body size numerically converge onto 1.

217 tching size in ammonoids as opposed to lower metabolic rates and much larger hatchlings in most nauti

218 High metabolic rates combined with small hatching size in amm

219 this novel scaffold that increased cellular metabolic rates in vitro using changes in oxygen consump

220 content, body size and temperature on plant metabolic rates.

221 Depletion of eIF5A or Tsc2 leads to metabolic re-initiation and proliferation, but at the ex

222 of genes encoding a reaction, identified 102 metabolic reactions with significant change in flux in M

223 characterize both the primary metabolism and metabolic regulation of C. acetobutylicum.

224 f how ratio-sensing is achieved in yeast GAL metabolic regulation, but also elucidated design princip

225 signal transducing systems are necessary for metabolic regulation, resistance to antibiotics and anti

226 ective HFD-induced hepatic expression of the metabolic regulator fibroblast growth factor 21 (FGF21)

227 iously identified agonists of this important metabolic regulator.

228 cells additionally showed activation-related metabolic remodeling deficits and decreased mitochondria

229 Interestingly, this metabolic remodeling did not improve insulin resistance,

230 porter SLC1A5 as an FTO target that promotes metabolic reprogramming and survival of VHL-deficient cc

231 itical driver of pancreatic cancer, promotes metabolic reprogramming and upregulates NRF2, a master r

232 Extensive metabolic reprogramming occurs during tumour initiation

233 e 2 cytokine interleukin-13 in orchestrating metabolic reprogramming that drives adaptation to endura

234 dependent signaling, which in turn regulates metabolic reprogramming, immune suppression, resistance

235 genesis, enabling tumour progression through metabolic reprogramming.

236 nal glucose metabolism and leads to distinct metabolic requirements and biological functions.

237 bacteriome multiplication to match increased metabolic requirements in emerging adults.

238 rarchy of the tissue of origin can alter the metabolic requirements of the cancer stem cell populatio

239 ating lymphocytes (TIL) and cancer cells for metabolic resources often renders T cells dysfunctional.

240 Furthermore, at follow-up, time to peak in metabolic responders increased significantly (P = 0.019)

241 Metabolic responders to ICI or TT on (18)F-FET PET had a

242 ulvestrant treatment induced a similar early metabolic response for both WT-ER and Y537S-ER tumors.

243 s the standardized criterion of PET complete metabolic response, confirming the value of the DS for p

244 nical benefit and a lasting radiographic and metabolic response.

245 terindividual variability in weight loss and metabolic responses depends upon interactions between ge

246 ral blood to determine immune functionality, metabolic responses, and transcriptome profiles.

247 tion inhibitory factor (MIF) in regulating a metabolic rhythm in the model light-organ symbiosis betw

248 tohepatitis (NASH) in adult individuals with metabolic risk factors, compared with individuals with n

249 k factors, compared with individuals with no metabolic risk factors.

250 analyses establish SERBP1 regulation role in metabolic routes preferentially used by cancer cells.

251 In this study, we provide evidence that a metabolic shift from glucose to lipid is a key mechanism

252 One direct consequence of this metabolic shift is the upregulation of cytoprotective (C

253 These observations indicate that a metabolic shift toward glycolysis accompanies collective

254 Metabolic shifting between glycolysis and mitochondrial

255 hol consumption could be partly explained by metabolic shifts.

256 In order to capture the metabolic signature of proliferating hepatocytes, we app

257 higher lipophilicity and can show increased metabolic stability and Caco-2 permeability.

258 tional groups leading to high solubility and metabolic stability but occasionally at the cost of redu

259 It also shows high metabolic stability in all species, linked to an adequat

260 gical tissue integrity, barrier function and metabolic stability over time.

261 to peptide limitations by displaying higher metabolic stability, good bioavailability and enhanced r

262 were significantly increased at the time of metabolic staging in mothers of children with presymptom

263 The metabolic state of an organism instructs gene expression

264 uring pupal development that establishes the metabolic state of the adult fly.

265 ed metabolism and conferred this compromised metabolic state to CD8(+) T cells, thereby paralyzing th

266 or pretransplant measurement of function and metabolic status to assess the suitability of the organ

267 We show that introducing dynamic metabolic strategies in consumer-resource models is nece

268 gnaling pathway when administered under mild metabolic stress conditions.

269 h type 2 diabetes the destructive effects of metabolic stress predominate and beta cell death or dysf

270 nockout-engineered heart tissue sensitive to metabolic stress such as serum withdrawal and restrictiv

271 hat Escherichia coli has evolved to minimize metabolic stress that results from the acquisition and u

272 patic inflammasome activation in response to metabolic stress through induction of lncRNA Gm15441.

273 n K2-upregulated glycolysis markedly induced metabolic stress, along with AMPK activation and mTORC1

274 phosphorylated SMAD1/5 acts in synergy with metabolic stress-activated FOXO1 through formation of a

275 g and maintaining systemic homeostasis under metabolic stress.

276 versity, which further sensitizes tumours to metabolic stress.

277 We propose that metabolic subphenotypes exist between CRCs due to intert

278 s that was significantly associated with the metabolic subtype (KCNH7/FIGN, P = 1.0 x 10-8).

279 isease (4% versus 7%) in patients undergoing metabolic surgery.

280 small molecule, and instead were driven by a metabolic switch in Th17 cells that led to the induction

281 supply, but rely on the ability to undergo a metabolic switch to glycolysis to allow them to perform

282 Metabolic syndrome (13.5%; 44 of 326) was related to tra

283 rent types of plant-based diets and incident metabolic syndrome (MetS) and components of MetS.

284 In order toevaluate the influence of the metabolic syndrome (MS) (obesity, hypertension, elevated

285 atic steatosis can be considered a marker of metabolic syndrome and diabetes.

286 is frequently associated with development of metabolic syndrome and insulin resistance, manifests whe

287 et for treating disordered energy metabolism metabolic syndrome and type 2 diabetes.

288 We report that parental metabolic syndrome epigenetically reprograms members of

289 Metabolic syndrome is a significant risk factor for seve

290 The metabolic syndrome is prevalent in developed nations and

291 ut diabetes, hypertension, dyslipidemia, the metabolic syndrome or impaired renal function.

292 racts could help mitigate the development of metabolic syndrome where EAEP and AEP skim proteins coul

293 mia, obesity, type 2 diabetes, hypertension, metabolic syndrome), but the mechanism underlying these

294 apeutic strategies to treat individuals with metabolic syndrome, as RXR heterodimerizes with multiple

295 highly inflammatory diet is associated with metabolic syndrome, hypertension, abdominal obesity, and

296 nsidering the prevalence of complications of metabolic syndrome, such as non-alcoholic fatty liver di

297 antial evidence implicates crosstalk between metabolic tissues and the immune system in the inception

298 In summary, we have identified intracellular metabolic traits associated with the 1q25 risk allele in

299 BATF-dependent and occurs via modulation of metabolic transcriptional programs.

300 dings provide genetic evidence for FBP1 as a metabolic tumour suppressor in liver cancer and establis