ライフサイエンスコーパス: metabolic abnormality

1 metabolic abnormality) or 'unhealthy' (>/=2 metabolic abnormalities).

2 e metabolic abnormality) or unhealthy (>/= 2 metabolic abnormalities).

3 e latter, 86 patients (39.3%) had at least 1 metabolic abnormality.

4 hionine metabolism is a fundamental acquired metabolic abnormality.

5 xO3a/AMPK/PPAR-alpha signaling and rectifies metabolic abnormalities.

6 etformin ameliorated cellular senescence and metabolic abnormalities.

7 ted levels of TWEAK in skeletal muscle cause metabolic abnormalities.

8 ry organ dysfunction contribute to resultant metabolic abnormalities.

9 uced adipocyte senescence and attenuated the metabolic abnormalities.

10 mutant mice largely normalizes the bone and metabolic abnormalities.

11 l product, beneficial in diabetes-associated metabolic abnormalities.

12 of obesity-associated insulin resistance and metabolic abnormalities.

13 s protective in men and women with clustered metabolic abnormalities.

14 n the pathogenesis of obesity and associated metabolic abnormalities.

15 otype of hematological, cardiopulmonary, and metabolic abnormalities.

16 role for B cells in the development of these metabolic abnormalities.

17 uld play a role in the pathogenesis of these metabolic abnormalities.

18 that folate exacerbates vitamin B-12-related metabolic abnormalities.

19 elop spontaneous intestinal inflammation and metabolic abnormalities.

20 ration AEDs are associated with a panoply of metabolic abnormalities.

21 ove energetics in athletes and patients with metabolic abnormalities.

22 lithiasis are more likely to have detectable metabolic abnormalities.

23 s (liver-specific macrophages, KCs) in these metabolic abnormalities.

24 ution and adipocyte size are associated with metabolic abnormalities.

25 rity nor defined growth hormone secretion or metabolic abnormalities.

26 entions for antipsychotic medication-induced metabolic abnormalities.

27 ted to insulin resistance and its associated metabolic abnormalities.

28 ogenic, while reducing abdominal obesity and metabolic abnormalities.

29 pe 2 diabetes is weight loss, which improves metabolic abnormalities.

30 ayed rate of weight gain, suggesting broader metabolic abnormalities.

31 ibutes to development of obesity and related metabolic abnormalities.

32 nergic and serotonergic systems and cerebral metabolic abnormalities.

33 not significantly improve obesity-associated metabolic abnormalities.

34 sses of subcutaneous fat in association with metabolic abnormalities.

35 te function that leads to the development of metabolic abnormalities.

36 n signaling leads to hyperglycemia and other metabolic abnormalities.

37 inical diagnosis despite having accompanying metabolic abnormalities.

38 he potential to ameliorate obesity and other metabolic abnormalities.

39 haracterized by reproductive, endocrine, and metabolic abnormalities.

40 n for SERT deficiency associated obesity and metabolic abnormalities.

41 mpared with normal weight individuals with 0 metabolic abnormalities.

42 ividuals increased with increasing number of metabolic abnormalities.

43 amatically improved both clinical course and metabolic abnormalities.

44 antipsychotic-induced weight gain and other metabolic abnormalities.

45 kin-6, a common risk factor for diabetes and metabolic abnormalities.

46 lp to treat a range of human conditions with metabolic abnormalities.

47 se, side effects from chemotherapy, or toxic-metabolic abnormalities.

48 ed siblings may be a possible risk group for metabolic abnormalities.

49 g obese subjects with asthma correlates with metabolic abnormalities.

50 ons between short sleep duration and chronic metabolic abnormalities.

51 onsiderable range of variation and potential metabolic abnormalities across the individuals in this c

52 with both FXR gene deletion and BA-mediated metabolic abnormalities after inactivation of FXR transc

53 These metabolic abnormalities, along with fasting hyperglycemi

54 ainst age-related obesity and its subsequent metabolic abnormalities, although their food intake is n

55 Metabolic abnormalities amplified the adverse effect of

56 ated with a number of clinically significant metabolic abnormalities and an increased risk of prematu

57 AMPK activation prevents the metabolic abnormalities and apoptosis specifically cause

58 on and heart failure that is associated with metabolic abnormalities and autonomic impairment.

59 d normal cardiac function despite myocardial metabolic abnormalities and cardiac-specific overactivat

60 avir is a protease inhibitor associated with metabolic abnormalities and cardiovascular disease.

61 s more on the improvement of obesity-related metabolic abnormalities and chronic disease risk reducti

62 nt association observed between IRS-defining metabolic abnormalities and colorectal cancer is determi

63 nimal model to study the interaction between metabolic abnormalities and experimentally induced asthm

64 peritoneal dialysis solutions may exacerbate metabolic abnormalities and increase cardiovascular risk

65 Abdominal obesity is associated with metabolic abnormalities and increased risk of atheroscle

66 alcium has been associated with a variety of metabolic abnormalities and may be associated with a gre

67 t on growth may be related to both postnatal metabolic abnormalities and prenatal defective bone form

68 Noticeably, metabolic abnormalities and proliferation driven by insu

69 n individuals who are normal weight can have metabolic abnormalities and similar risks for cardiovasc

70 Metabolic abnormalities and targeted treatment trials ha

71 ase characterized by neurological disorders, metabolic abnormality and premature death.

72 or development of obesity and its associated metabolic abnormalities, and abrogation of insulin signa

73 The link between adiposity, metabolic abnormalities, and arterial disease progressio

74 fined by profound circulatory, cellular, and metabolic abnormalities, and associated with a greater m

75 the duration of diabetes, insulin treatment, metabolic abnormalities, and autonomic neuropathy.

76 ted > or =8 hours, two thirds had at least 1 metabolic abnormality, and nearly 1 in 10 had MetS.

77 These metabolic abnormalities appear to result from chronic el

78 icularly profound circulatory, cellular, and metabolic abnormalities are associated with a greater ri

79 which underlying circulatory, cellular, and metabolic abnormalities are associated with a greater ri

80 Maternal prenatal metabolic abnormalities are associated with high insulin

81 evidence indicates that obesity and related metabolic abnormalities are associated with increased in

82 ere pre-existing hemodynamic instability and metabolic abnormalities are combined with long periods o

83 We show how genetic and metabolic abnormalities are inextricably linked to dysre

84 bnormalities in the absence of structural or metabolic abnormalities are likely to have disease-causi

85 It follows that disease-related metabolic abnormalities are likely to impinge upon SIRT1

86 dvantageous for minority populations because metabolic abnormalities are present at higher levels of

87 These metabolic abnormalities are risk factors for kidney dise

88 Fat redistribution and metabolic abnormalities are seen increasingly in HIV-pos

89 y or fat re-distribution, and its associated metabolic abnormalities, are common in HIV patients.

90 ATF4 only in osteoblasts presented the same metabolic abnormalities as Atf4-/- mice.

91 er fat is more important than the associated metabolic abnormalities as the predictor of future liver

92 ; and transcription factor, ion channel, and metabolic abnormalities, as well as growth factor-depend

93 ntrations may be responsible for many of the metabolic abnormalities associated with abdominal obesit

94 Subclinical metabolic abnormalities associated with adrenal incident

95 ngs provide insight into the pathogenesis of metabolic abnormalities associated with diabetes.

96 ated receptor-gamma agonists may correct the metabolic abnormalities associated with disrupted adipog

97 ted therapies to improve liver histology and metabolic abnormalities associated with fatty liver are

98 P4-Wnt10b mice largely avert weight gain and metabolic abnormalities associated with genetic obesity.

99 normalize impaired PPAR-alpha expression or metabolic abnormalities associated with GSD-Ia.

100 Metabolic abnormalities associated with human immunodefi

101 y mass index (weight (kg)/height (m)(2)) and metabolic abnormalities associated with insulin resistan

102 ope tracing experiments, we find a number of metabolic abnormalities associated with loss of Gpt2.

103 s body weight, and increasing FGF21 improves metabolic abnormalities associated with obesity and diab

104 tributes to the insulin resistance and other metabolic abnormalities associated with severe lipodystr

105 Taken together, these findings reveal novel metabolic abnormalities associated with the CF pathologi

106 en species (ROS) is one of the major retinal metabolic abnormalities associated with the development

107 hese relatives also had lower frequencies of metabolic abnormalities at baseline and exhibited no ove

108 bited hepatic gluconeogenesis and alleviated metabolic abnormalities both in mice with diet-induced o

109 of the patients themselves also demonstrated metabolic abnormalities, both on and off galactose-restr

110 ing has been proposed to contribute to these metabolic abnormalities but has not been directly demons

111 revalence and correlates of the phenotype of metabolic abnormality but normal weight (MAN) for 5 raci

112 Puerto Rican adults have prevalent metabolic abnormalities, but few studies have explored f

113 N2), demonstrated significant functional and metabolic abnormalities, but grossly normal structure, i

114 The failing human heart is characterized by metabolic abnormalities, but these defects remains incom

115 sing CEACAM1 in liver curtailed diet-induced metabolic abnormalities by protecting hepatic insulin cl

116 among obese persons without obesity-related metabolic abnormalities, called metabolically healthy ob

117 Metabolic abnormalities can be identified in the majorit

118 Dietary fructose that is linked to metabolic abnormalities can up-regulate its own absorpti

119 and that the obese phenotype, regardless of metabolic abnormalities, can adversely affect renal func

120 constriction, microcirculatory rarefaction, metabolic abnormalities, cardiac hypertrophy, and increa

121 Whether homocysteine per se or a coincident metabolic abnormality causes vascular disease is still a

122 fic ablation of Mfn2 in mice led to numerous metabolic abnormalities, characterized by glucose intole

123 Metabolic abnormalities consistent with early indication

124 nts without diabetes, supports the idea that metabolic abnormalities contribute to their adverse outc

125 ars before the onset of type 2 diabetes) and metabolic abnormalities contribute.

126 authors to hypothesize that the incidence of metabolic abnormalities contributing to treatment-refrac

127 ypes, diverse oncogenic, transcriptional and metabolic abnormalities cooperate to generate hostile mi

128 Hippocampal subfield and metabolic abnormalities detected at 7T appear to reflect

129 Metabolic abnormalities develop in various chronic disea

130 dy insulin sensitivity regulation and to the metabolic abnormalities developed in AR-deficient male m

131 ormal weight, overweight, and obesity) and 3 metabolic abnormalities (diabetes, hypertension, and hyp

132 In relation to AMI, obesity without metabolic abnormalities did not confer substantial exces

133 s led to the theory that diabetes-associated metabolic abnormalities directly impair neural retinal f

134 hange in functional islet mass correlated to metabolic abnormalities during the course of alloimmune

135 duction system and myocardium, postoperative metabolic abnormalities, electrolyte disturbances, and i

136 ges of AD progression, prominent atrophy and metabolic abnormalities emerged in these posterior corti

137 ed to motor neurons and includes synapse and metabolic abnormalities, endoplasmic reticulum (ER) stre

138 minates this gradient and is associated with metabolic abnormalities, functionally restoring the phys

139 ble evidence, we propose a paradigm in which metabolic abnormalities, genetic injury, and systemic va

140 w-up of 5.4 years, obese individuals with no metabolic abnormalities had a higher risk of CHD (multiv

141 Disrupted mitochondrial function and metabolic abnormalities have a causal role too.

142 ildren, disrupted mitochondrial function and metabolic abnormalities have a causal role.

143 relatively unexplored despite the fact that metabolic abnormalities have been implicated in the path

144 Metabolic abnormalities have been widely reported in dep

145 g obesity-associated cardiovascular risk and metabolic abnormalities; however, the regulatory network

146 occasionally is associated with endocrine or metabolic abnormality (hypothyroidism, panhypopituitaris

147 ia, a sizable body of data suggests a second metabolic abnormality-iatrogenic hyperinsulinemia-princi

148 scopic imaging permits detection of regional metabolic abnormalities in ALS, including not only the m

149 ic syndrome is characterized by a cluster of metabolic abnormalities in an individual, with insulin r

150 edictor of future cardiovascular disease and metabolic abnormalities in apparently healthy men and wo

151 nt studies have implicated physiological and metabolic abnormalities in autism spectrum disorders (AS

152 Notably, FKRP-deficient mice elicit diverse metabolic abnormalities in biomarkers of extracellular m

153 (18)F-FDG studies detect metabolic abnormalities in demented patients, but with l

154 hyperglycemia on the inflammatory response, metabolic abnormalities in diabetes, and the interaction

155 city accompanies the more clinically evident metabolic abnormalities in diabetes.

156 or neurotrophins reverse some functional and metabolic abnormalities in diabetic nerves, they only pa

157 w in the future the early detection of focal metabolic abnormalities in diseases that affect the func

158 s of adiposity most strongly associated with metabolic abnormalities in elderly men.

159 tive database to facilitate the detection of metabolic abnormalities in future patient scans.

160 ole in HD pathogenesis, although evidence of metabolic abnormalities in HD patients is inconsistent.

161 n atrophy and attenuates mutant-HTT-mediated metabolic abnormalities in Huntington's disease mice.

162 fic expression of AMPKgamma3(R225Q) prevents metabolic abnormalities in leptin-deficient ob/ob (ob/ob

163 of beta-oxidative genes, results in profound metabolic abnormalities in liver and heart.

164 y acid metabolism with future development of metabolic abnormalities in MHO individuals, we retrospec

165 y markers associated with the development of metabolic abnormalities in MHO individuals.

166 prevented and reversed high-fat diet-induced metabolic abnormalities in mice by decreasing PPARgamma

167 lities, hypotonia, seizures, neuropathy, and metabolic abnormalities in multiple organ systems.

168 (Tregs) could alleviate the pathological and metabolic abnormalities in ob/ob mice.

169 Thus, overstimulation of ENaC by metabolic abnormalities in obese individuals may be a li

170 cid species is a potential biomarker for the metabolic abnormalities in obesity.

171 :DCAS ratio may be a promising biomarker for metabolic abnormalities in obesity.

172 These metabolic abnormalities in offspring born to obese mice

173 aim of this study was to characterize brain metabolic abnormalities in patients with macrophagic myo

174 eneration antipsychotics are associated with metabolic abnormalities in patients with schizophrenia.

175 rsenite exacerbated adipocyte senescence and metabolic abnormalities in pol eta(-/-) mice.

176 ocks, and whether disruptions are related to metabolic abnormalities in pregnancy, by studying day/ni

177 nourished donors also ameliorated growth and metabolic abnormalities in recipient animals.

178 ion of draggen mice uncovered novel systemic metabolic abnormalities in Scn4a mouse models and provid

179 efect in the neonatal beta cell fraction and metabolic abnormalities in the adult.

180 Dietary nitrate therefore alleviates metabolic abnormalities in the hypoxic heart, improving

181 ggest a role for 12alpha-hydroxylated BAs in metabolic abnormalities in the natural history of T2D an

182 vestigated clinical correlates of tryptophan metabolic abnormalities in the nontumoral hemisphere of

183 These additional defects indicate that metabolic abnormalities in these cells are not limited t

184 The metabolic abnormalities in these mice are improved by in

185 ptive transfer of BMDCs affects vascular and metabolic abnormalities in these mice.

186 ractile genes, leading to a feedback loop of metabolic abnormalities in these SMCs.

187 ncluding type 2 diabetes, and assessment for metabolic abnormalities in those with obstructive sleep

188 idative stress are processes that mark early metabolic abnormalities in vascular diseases.

189 mains unknown whether hyperglycemia, a major metabolic abnormality in diabetes, regulates MMP express

190 blood glucose (hyperglycemia) is a hallmark metabolic abnormality in diabetes.

191 These metabolic abnormalities, in turn, impair learning in the

192 gested that periodontitis is associated with metabolic abnormalities including non-alcoholic fatty li

193 ion syndromes as well as patients with other metabolic abnormalities including patients with chronic

194 xiety-like behavior, impaired cognition, and metabolic abnormalities, including glucose intolerance.

195 Prenatal metabolic abnormalities, including higher pregravid BMI

196 sity in preschool children the prevalence of metabolic abnormalities, including hypertension, dyslipi

197 agents often lose subcutaneous fat and have metabolic abnormalities, including insulin resistance an

198 free testosterone levels as well as several metabolic abnormalities, including insulin resistance, d

199 e is associated with myocardial and systemic metabolic abnormalities, including low levels of total c

200 levels have been associated with a range of metabolic abnormalities, including obesity and insulin r

201 by marked increase in abdominal fat mass and metabolic abnormalities, including reduction of both glu

202 pitulate key aspects of diabetes without the metabolic abnormalities, including retinal vascular dama

203 ith FASDs that had an increased incidence of metabolic abnormalities, including type 2 diabetes, low

204 Leptin treatment dramatically improves metabolic abnormalities (insulin resistance and hyperlip

205 t loss induced by GBP surgery normalizes the metabolic abnormalities involved in the pathogenesis and

206 The pathophysiology of glucose metabolic abnormalities is poorly understood, but insuli

207 However, the link between energetic and metabolic abnormalities is unknown.

208 keletal proteins and is also associated with metabolic abnormalities, is discussed.

209 istance, by promoting dyslipidemia and other metabolic abnormalities, is part of the proatherogenic m

210 lin resistance (IR), dyslipidemia, and other metabolic abnormalities, is responsive to antidiabetic t

211 to compare with a disease cohort with known metabolic abnormalities, it is important to derive one's

212 dhood obesity is associated with a number of metabolic abnormalities leading to increased cardiovascu

213 ctual developmental disorder and unexplained metabolic abnormalities led to a diagnosis in 68%, the i

214 These metabolic abnormalities led to an increase in biliary ch

215 The metabolic abnormalities may be partially or completely c

216 In addition, metabolic abnormalities may influence the results obtain

217 ggest insulin resistance, and its associated metabolic abnormalities, may underlie many of the cardio

218 nvestigate whether obesity in the absence of metabolic abnormalities might be a relatively benign con

219 siology of CFRD, and imply that carbohydrate metabolic abnormalities might begin at much younger ages

220 dels of diabetes, TEPP-46 treatment reversed metabolic abnormalities, mitochondrial dysfunction and k

221 H and idiopathic PAH BOECs recapitulated the metabolic abnormalities observed in pulmonary artery end

222 extent to which skeletal muscle (SM) energy metabolic abnormalities occur and contribute to EI and i

223 Correction of metabolic abnormalities occurred only with KD.

224 ing DC were resistant to the weight gain and metabolic abnormalities of an HFD.

225 one are inadequate to reverse the underlying metabolic abnormalities of cancer cachexia and have limi

226 gamma (PPAR-gamma) agonists not only improve metabolic abnormalities of diabetes and consequent diabe

227 The metabolic abnormalities of diabetes cause mitochondrial

228 Our results show that the metabolic abnormalities of DIO can be mitigated by sensi

229 ve been found to play important roles in the metabolic abnormalities of GBM.

230 C2cd4a in beta cells of mice phenocopied the metabolic abnormalities of human carriers of C2CD4A-link

231 y, this failed to correct the aforementioned metabolic abnormalities of Hyp mice.

232 ic HyUA, although clearly a biomarker of the metabolic abnormalities of obesity, does not appear to b

233 ons have been shown to reproduce some of the metabolic abnormalities of obesity.

234 role for these cells in the etiology of the metabolic abnormalities of obesity/type 2 diabetes.

235 ifically targeted to ameliorate the systemic metabolic abnormalities of this disorder.

236 In severe cases, the metabolic abnormalities of TLS can cause renal failure,

237 Correction of metabolic abnormalities offers unique opportunities for

238 In order to study the effects of metabolic abnormalities on arrhythmias without the compl

239 motility disorder caused initially either by metabolic abnormalities or by a primary motility alterat

240 cellular ribose uptake can be indicative of metabolic abnormalities or tumorigenesis.

241 lassified as 'metabolically healthy' (0 or 1 metabolic abnormality) or 'unhealthy' (>/=2 metabolic ab

242 sified as metabolically healthy (zero or one metabolic abnormality) or unhealthy (>/= 2 metabolic abn

243 y no evidence of basal inflammatory disease, metabolic abnormalities, or enhanced resistance to Salmo

244 mbocytopenia, gastrointestinal disturbances, metabolic abnormalities, peripheral neuropathy, and hype

245 dings suggest that both the reproductive and metabolic abnormalities persist with age in PCOS.

246 ve damage is a cause or a consequence of the metabolic abnormalities present in diabetic subjects.

247 of this characterization and multiple other metabolic abnormalities recently associated with ccRCC,

248 onsumption, already associated with numerous metabolic abnormalities, reduces rates of intestinal Ca(

249 lower when other cerebral physiological and metabolic abnormalities reflected depressed neuronal fun

250 elevated ferritin may be just one of several metabolic abnormalities related to the underlying proces

251 plasma fatty acid distribution are linked to metabolic abnormalities related to type 2 diabetes and c

252 ation in CGM reflects underlying neuroaxonal metabolic abnormalities relevant to disease course heter

253 y acids, but the molecular driver(s) of this metabolic abnormality remains obscure.

254 Metabolic abnormalities responsible for stone recurrence

255 disease characterized primarily by numerous metabolic abnormalities, retinal degeneration, cardiomyo

256 n this review, we describe changes involving metabolic abnormalities secondary to hyperglycemia, oxid

257 are commonly seen, and the severity of these metabolic abnormalities seems to be related to the exten

258 hat partial RYR2 loss is sufficient to cause metabolic abnormalities seen in heart disease.

259 R-alpha overexpression without affecting the metabolic abnormalities seen in these hearts.

260 define chronic kidney disease (CKD) identify metabolic abnormalities similarly in minority and nonmin

261 es resulting from mitochondrial dysfunction, metabolic abnormalities, storage diseases, and inborn er

262 The treatment of associated metabolic abnormalities such as insulin resistance and h

263 AT) and ultimately other tissues, leading to metabolic abnormalities such as insulin resistance, type

264 Metabolic abnormalities such as obesity were linked with

265 lescents appear to be more likely to develop metabolic abnormalities such as pronounced weight gain,

266 binoid receptor reduces obesity and improves metabolic abnormalities such as triglycerides, HDL chole

267 d to both cancer metabolism as well as other metabolic abnormalities, such as fatty liver disease and

268 These factors include metabolic abnormalities, such as hyperglycemia, elevated

269 se long-term outcomes even in the absence of metabolic abnormalities, suggesting that there is no hea

270 metabolically healthy, but simply have fewer metabolic abnormalities than those with metabolically un

271 VHL-mutant cells exhibit metabolic abnormalities that can cause chronic endoplasm

272 ogies often coexist with drug toxicities and metabolic abnormalities that complicate the development

273 , the primary in vitro model of IBC, exhibit metabolic abnormalities that distinguish them from other

274 bolic syndrome is a group of obesity-related metabolic abnormalities that increase an individual's ri

275 Identifying metabolic abnormalities that occur before pancreatic duc

276 in providing a means to link the myocardial metabolic abnormalities that occur in rat of disease wit

277 l PET are consistent with the expected early metabolic abnormalities that occur in this well-characte

278 nd to potentially minimize fetal exposure to metabolic abnormalities that program future disease.

279 on, oxidant stress, inflammation, and muscle metabolic abnormalities that provide opportunities for t

280 ct of the TVB-2640 in obese men with certain metabolic abnormalities that put them at risk for NAFLD.

281 alterations in blood pressure, or can cause metabolic abnormalities that subsequently increase risk

282 plasma ferritin levels, may induce baseline metabolic abnormalities that ultimately result in diabet

283 bese population who appear to be free of the metabolic abnormalities that usually accompany excess ad

284 postprandial hyperlipidemia is one specific metabolic abnormality that is typically associated with

285 onfirmed chronic prostatitis may demonstrate metabolic abnormality that leads to false-positive diagn

286 , including fluid infusion and correction of metabolic abnormalities, to save more lives.

287 is not known whether sleep disturbances and metabolic abnormalities underlying the weight loss are p

288 Dose-limiting grade 3 metabolic abnormalities were also observed.

289 s estimated from serum creatinine values and metabolic abnormalities were defined by 5th or 95th perc

290 fferent mouse models of breast cancer, these metabolic abnormalities were found to accelerate the dev

291 Metabolic abnormalities were more common in minority pop

292 bolically healthy, the active with clustered metabolic abnormalities were not at elevated risk of car

293 However, these metabolic abnormalities were prevented when liver was de

294 These metabolic abnormalities were rescued by treatment with n

295 ombination antiretroviral therapy results in metabolic abnormalities which increase cardiovascular di

296 red throughout the development of intestinal metabolic abnormalities, which could contribute to dysli

297 he host in response to tumour presence cause metabolic abnormalities, which result in decreased prote

298 Maladaptive RVH shares metabolic abnormalities with cancer including aerobic gl

299 to investigate the associations of prenatal metabolic abnormalities with insulin and adiponectin in

300 gat1 in HTF-C diet-fed mice improves hepatic metabolic abnormalities without attenuating liver inflam