ライフサイエンスコーパス: metabolic activation

1 la typhimurium strain TA98 (with and without metabolic activation).

2 onse to several model genotoxicants (without metabolic activation).

3 y, thereby demonstrating the requirement for metabolic activation.

4 cleotide cofactor consistent with a need for metabolic activation.

5 extent by the pathway in which HNE undergoes metabolic activation.

6 locked stress-induced m-PFC DA, 5-HT, and NE metabolic activation.

7 or SEC may be attributable to differences in metabolic activation.

8 er N6-purine deamination compatible with its metabolic activation.

9 mutagenicity, and DNA cross-linking through metabolic activation.

10 these studies have considered the effects of metabolic activation.

11 (5000 mug/plate) in the TA98 strain without metabolic activation.

12 hE in vivo either directly or as a result of metabolic activation.

13 s found to form multiple GSH conjugates upon metabolic activation.

14 nella strains TA 100 and 98 with and without metabolic activation.

15 d increases in ATP demand and Ca2+-dependent metabolic activation.

16 A1 is more important in detoxication than in metabolic activation.

17 er procarcinogens that require P450-mediated metabolic activation.

18 local alterations in flow, inflammation, and metabolic activation.

19 clopidogrel and prasugrel, does not require metabolic activation.

20 as an electrophile either directly or after metabolic activation; 2) be genotoxic; 3) alter DNA repa

21 Following metabolic activation, AA reacts with dA and dG residues

22 annels (permethrin) and a compound requiring metabolic activation (allyl alcohol).

23 However, mechanisms eliciting metabolic activation, an inseparable step for satellite

24 g/kg), inhibited both ketamine-induced brain metabolic activation and behavioral responses in the wil

25 induced hyperthermia via inhibition of brain metabolic activation and blockade of skin vasoconstricti

26 ims to address this gap by investigating the metabolic activation and chemical characterization of DN

27 hen hepatotoxicity is mediated by an initial metabolic activation and covalent binding, and subsequen

28 One of these, CYP3A4/5 is involved in metabolic activation and detoxification of a wide number

29 ng mechanisms; individual differences in the metabolic activation and detoxification of carcinogens,

30 CYP1A1 and GSTM1 play a major role in the metabolic activation and detoxification of PAHs, respect

31 ns hematopoietic stem cells under persistent metabolic activation and differentiation towards the meg

32 induced lung tumors is a result of decreased metabolic activation and DNA binding of NNK.

33 s expression of the AMPKa2 subunit to induce metabolic activation and drive robust viral replication.

34 (2) receptors and downstream signals on ILC2 metabolic activation and effector function were examined

35 oxicity induced in SEC is determined by both metabolic activation and GSH detoxification in the hepat

36 which intestinal microbes contribute to the metabolic activation and gut toxicity of TCS, and highli

37 AMP-activated protein kinase (AMPK) regulate metabolic activation and have been found to be important

38 BaP forms covalent DNA adducts after metabolic activation and induces mutations.

39 camptothecin analogue CPT-11, which requires metabolic activation and is toxic.

40 pendent on hepatic microsomal P450-catalyzed metabolic activation and that acetaminophen toxicity in

41 Both genotoxicity with and without metabolic activation and the induction of the oxidative

42 attributed to the changes in the rates of CY metabolic activation and/or detoxification.

43 cipating in induction of secretory activity, metabolic activation, and intracellular signaling/signal

44 Following metabolic activation, aristolochic acid reacts with DNA

45 to be Ah receptor-dependent, indicating that metabolic activation by CYP1A1 was required.

46 These procarcinogens undergo metabolic activation by N-oxidation of the exocyclic ami

47 al chemicals and blubber extracts subject to metabolic activation by rat liver S9 fraction.

48 ine phosphatases (PTPases) regulate cellular metabolic activation by reversing the effects of tyrosin

49 This toxic reaction is associated with metabolic activation by the P450 system to form a quinon

50 AHs are environmental carcinogens that, upon metabolic activation, can react with DNA to form bulky c

51 a carcinogen in cigarette smoke which, after metabolic activation, can react with the exocyclic N (2)

52 inal fluid and triggers a wave of microglial metabolic activation characterized by mitochondrial memb

53 emistry of the cations but to differences in metabolic activation/deactivation of individual amines.

54 e into play including differences in uptake, metabolic activation, degradation, and transport.

55 gy, Nkx3.1(+/-) mice demonstrated indices of metabolic activation, DNA damage response, and stress re

56 protein expression of FMO were not changed, metabolic activation elicited by octylamine and human ur

57 ization (LCGU) and the spatial extent of the metabolic activation following stimulation of the spared

58 of metabolites and has been shown to require metabolic activation for antiangiogenic activity.

59 ay testing and highlighted the importance of metabolic activation for TTR binding.

60 exposures above the median (implying slower metabolic activation) had a shorter survival than those

61 Despite the importance of metabolic activation in HCA carcinogenicity and the find

62 ketamine-induced behavior and regional brain metabolic activation in mice provides a useful model for

63 quantitative mathematical description of the metabolic activation in neurons and glial cells, as well

64 he essential role of pulmonary P450-mediated metabolic activation in NNK-induced lung cancer, and our

65 D(1A) knockout mice exhibited blunted metabolic activation in response to ketamine in a neuroa

66 ects in humans and both behavioral and brain metabolic activation in rodents.

67 adrenocortical activation, and dopaminergic metabolic activation in the m-PFC.

68 y microsomal cytochrome P450 (P450)-mediated metabolic activation in xenobiotic-induced lung cancer.

69 oral P2Y(12) inhibitor that does not require metabolic activation, in patients undergoing nonurgent p

70 Metabolic activation increased the TTR binding potency o

71 xy-D-glucose scans were acquired to quantify metabolic activation, indicating local neutrophilic infl

72 says with the TA 100 strain with and without metabolic activation, indicating the mutagenic effect wa

73 e involvement of dopamine receptors in brain metabolic activation induced by ketamine is, however, un

74 s (PAHs) are potent carcinogens that require metabolic activation inside cells.

75 Metabolic activation is a key prerequisite for PAHs to c

76 This metabolic activation is dependent specifically on sensor

77 Its metabolic activation leads to trans-11,12-dihydroxy-11,1

78 However, metabolic activation led to an increase in some types of

79 After metabolic activation, many N-nitroso compounds are conve

80 However, the metabolic activation may occur as well.

81 ma (A549) cells, we provide evidence for the metabolic activation of (+/-)-trans-7,8dihydroxy-7,8-dih

82 e and recombinant p450s to contribute to the metabolic activation of 3-NBA by nitroreduction.

83 and 3A4 and of NADPH: p450 reductase in the metabolic activation of 3-NBA, catalyzing DNA adduct for

84 1A2 and 2C10 are important catalysts of the metabolic activation of 5-MeC and 6-MeC in human liver,

85 r interest, CYP2A13 was highly active in the metabolic activation of a major tobacco-specific carcino

86 d, the same enzyme inhibitors that block the metabolic activation of a series of nephrotoxic halogena

87 ome P450 enzymes play a critical role in the metabolic activation of acetaminophen, it is not yet cle

88 oxin-driven mutagenesis is initiated through metabolic activation of aflatoxin B1 (AFB1) to its epoxi

89 , hGMPK has been assigned a critical role in metabolic activation of antiviral and antineoplastic nuc

90 NAs) encoding cytochrome2E1 required for the metabolic activation of AOM and CCl(4) were observed bet

91 mal models, that neuronal activity-dependent metabolic activation of astrocytes is mediated by neurom

92 unosuppression and early death due to absent metabolic activation of BaP by CYP1B1 in immune cells.

93 gene superfamily and are responsible for the metabolic activation of both xenobiotics and endobiotics

94 ggested that oxidative stress resulting from metabolic activation of carcinogenic estrogens plays a c

95 dy the effect of complex PAH mixtures on the metabolic activation of carcinogenic PAH to DNA-binding

96 Electrophiles formed during metabolic activation of chemical carcinogens and reactiv

97 The results indicate that metabolic activation of DB[a,l]P by cytochrome P450 enzy

98 ain adducts formed in the same cell lines by metabolic activation of DB[a,l]P or (-)-DB[a,l]P-trans-1

99 Metabolic activation of drugs to electrophilic species i

100 exploiting intratumoural CYP expression for metabolic activation of duocarmycin-based prodrugs such

101 Metabolic activation of endogenous and exogenous chemica

102 Metabolic activation of EQ and EN generates the catechol

103 he ATs are likely to be involved both in the metabolic activation of exogenous carcinogenic amines as

104 The findings suggest that metabolic activation of FMO-mediated TMAO formation is a

105 We now report the metabolic activation of FTY720 by sphingosine kinase-2 a

106 ary gland is catalytically active toward the metabolic activation of HCA food mutagens, and that this

107 However, both enzymes were active in the metabolic activation of hexamethylphosphoramide, a nasal

108 d CYP2A13 was more active than CYP2A6 in the metabolic activation of hexamethylphosphoramide, N,N-dim

109 We therefore propose that the metabolic activation of HNE involves formation of an acy

110 ATP sulfurylase/APS kinase catalyses the metabolic activation of inorganic sulfate to PAPS, the u

111 Metabolic activation of intermediate PAH trans-dihydrodi

112 ty acid-induced deleterious inflammatory and metabolic activation of macrophages.

113 calized NQO1 was not attributable to greater metabolic activation of MC but instead was the result of

114 ction against myelogenous hyperplasia and in metabolic activation of menadione, leading to hepatic to

115 data demonstrate that Phb2 is essential for metabolic activation of mitochondria and, as a consequen

116 se data show a major in vivo role of NQO1 in metabolic activation of mitomycin C with implications in

117 at incretin-derived cAMP participates in the metabolic activation of mTOR by mobilizing intracellular

118 tability of 12 indicate the possibility that metabolic activation of N-nitrosomorpholine by hydroxyla

119 tively, and CYP2E1 plays a major role in the metabolic activation of nitrosamines.

120 A549 cells implicates the AKR pathway in the metabolic activation of PAH in human lung.

121 This work highlights the metabolic activation of PAH toxicity by a co-occurring P

122 t tube or in cell culture these enzymes show metabolic activation of PAHs or arylamines, whereas in t

123 trating a need for additional studies on the metabolic activation of penclomedine to identify the ult

124 and should be applicable to the study of the metabolic activation of PhIP in various human tissues.

125 also been implicated in participating in the metabolic activation of polycyclic aromatic hydrocarbon

126 1A1 and 1B1 are the major P450s involved in metabolic activation of polycyclic aromatic hydrocarbons

127 (393)/Ser(395)) and that this is mediated by metabolic activation of protein phosphatase 2A in comple

128 Human aldo-keto reductases catalyze the metabolic activation of proximate carcinogenic PAH trans

129 Metabolic activation of retinol (vitamin A) via sequenti

130 Metabolic activation of retinol into the hormone retinoi

131 Metabolic activation of some N-nitroso compounds (NOCs),

132 These data suggest a proficient metabolic activation of tamoxifen in human liver and an

133 enicity of tamoxifen have been attributed to metabolic activation of tamoxifen to an electrophile.

134 servation that CYP2D6 is responsible for the metabolic activation of tamoxifen to endoxifen.

135 w that intestinal commensal microbes mediate metabolic activation of TCS in the colon and drive its g

136 (SRD5A2) gene, the product of which controls metabolic activation of testosterone to dihydrotestoster

137 Metabolic activation of the aristolochic acids leads to

138 hese findings provide the first evidence for metabolic activation of the caudate nuclei in working me

139 electrophilic tamoxifen species generated by metabolic activation of the drug.

140 Metabolic activation of the K-region trans-8,9-diol of t

141 dence of amygdalar control of stress-induced metabolic activation of the monoaminergic systems in the

142 important mutagenic lesion formed following metabolic activation of the tobacco-specific carcinogen

143 s of pyridyloxobutylation resulting from the metabolic activation of the tobacco-specific nitrosamine

144 , whereas P450 1A1 plays a major role in the metabolic activation of these compounds in human lung.

145 tic activity and which may result in altered metabolic activation of tobacco smoke procarcinogens.

146 CYP2A13, which is highly active in the metabolic activation of tobacco-specific nitrosamines, i

147 as chemoprevention agents by preventing the metabolic activation of toxic quinones such as menadione

148 reductase (P450R) plays a major role in the metabolic activation of TPZ.

149 ly, l-NA treatment did not alter the area of metabolic activation on either the non-deafferented side

150 intracerebrally and is believed to be on the metabolic activation pathway of penclomedine.

151 antiviral activity and/or use an alternative metabolic activation pathway, and/or display a unique me

152 Following metabolic activation, PhIP causes bulky DNA lesions at t

153 alpha-CNPs (i) do not require metabolic activation (phosphorylation), (ii) bind direct

154 racts from Aristolochia species, form (after metabolic activation) pro-mutagenic DNA adducts in renal

155 -T cell receptor (pre-TCR) induces thymocyte metabolic activation, proliferation, survival and differ

156 is a carcinogen in cigarette smoke that upon metabolic activation reacts with guanine.

157 onization mass spectrometry, we identify the metabolic activation related protein complex of CD147-CD

158 Metabolic activation resulted in both enhanced and reduc

159 acting with DNA either directly or following metabolic activation, resulting in covalently linked com

160 murium strain TA98 was used with and without metabolic activation (S9 mix).

161 phimurium tester strains TA98 and TA100 with metabolic activation (S9) and a cancer cell line M12.C3.

162 In addition, metabolic activation should always be included within in

163 gen phosphorylase a (GPa) is correlated with metabolic activation, suggesting its potential use as a

164 ckade by clozapine of ketamine-induced brain metabolic activation suggests that antagonism of the con

165 and TA97a, in the presence and absence of a metabolic activation system prepared from the livers of

166 a pretreatment process based on an in vitro metabolic activation system, a comprehensive biological

167 otoxicity of thiopurine drugs involves their metabolic activation, the resultant generation of 6-thio

168 e been isolated as arising from this mode of metabolic activation, there are no selective, total synt

169 revealed a highly differentiated pattern of metabolic activation throughout the rostrocaudal extent

170 defect filtering) have enabled screening for metabolic activation to become routine during drug devel

171 addition of Sia to glycoconjugates requires metabolic activation to CMP-Sia, catalyzed by CMP-Sia sy

172 neurotoxicant tri-o-cresyl phosphate, after metabolic activation to cresyl saligenin phosphate makes

173 ntagonism by Itpkb restricts pre-TCR induced metabolic activation to enforce coincidence-detection of

174 hionamide (ETA), a prodrug that must undergo metabolic activation to exert its cytotoxic effects, is

175 ycyclic aromatic hydrocarbons (PAHs) require metabolic activation to exert their carcinogenic effects

176 TPZ requires metabolic activation to give a cytotoxic free radical sp

177 cks glycerol production indirectly after its metabolic activation to methylarsenite (MAs(III)), which

178 CPA undergoes metabolic activation to phosphoramide mustard and nornit

179 drug, requires hepatic cytochrome P450 (CYP) metabolic activation to produce the active metabolite th

180 Reports that HU undergoes metabolic activation to species that induce mutation app

181 Upon metabolic activation to the reactive epoxide, AFB1 forms

182 ding to their elimination and often to their metabolic activation to toxic products.

183 re coexpressed in a context of mitochondrial metabolic activation unique to suicide by violent means.

184 ophages, associated with immune response and metabolic activation upon oxidative stress.

185 t that AF is uniquely able to induce its own metabolic activation via CYP1A1/1A2 in duction to cytoto

186 Moreover, metabolic activation with CL316,243 further reduced mito

187 hemical species can react, directly or after metabolic activation, with DNA to yield DNA adducts.