ライフサイエンスコーパス: metabolic profile

1 ciated with higher adiposity but a favorable metabolic profile.

2 ses by eliciting changes in the A. baumannii metabolic profile.

3 erogeneous populations of EVs based on their metabolic profile.

4 ed the expression of PDK4 and had an altered metabolic profile.

5 nd was further aggravated by an unfavourable metabolic profile.

6 y acids, and amino acids) on later offspring metabolic profile.

7 consumption and/or a shift to a more reduced metabolic profile.

8 iponectin concentration affects the systemic metabolic profile.

9 changes in the liver that impact whole-body metabolic profile.

10 here the presence of fluorine influences the metabolic profile.

11 random forest tests were used to distinguish metabolic profiles.

12 substrates by cell lines harboring different metabolic profiles.

13 atenin signaling, correlating with differing metabolic profiles.

14 relate the impact of co-cultivation to their metabolic profiles.

15 mycin as a tool compound to study changes in metabolic profiles.

16 CO(2) and Fe affected metabolic profiles.

17 (epithelial-to-mesenchymal transition), and metabolic profiles.

18 r samples, which lack in vivo functional and metabolic profiling.

19 samples were studied with non-targeted LC-MS metabolic profiling.

20 ta processing tools have enabled large scale metabolic profiling.

21 n this pilot study, we sought to explore the metabolic profile across manifest HD from early to advan

22 has been greatly facilitated by genomic and metabolic profiling advances.

23 Metabolic profiling allows simultaneous measurement of h

24 statistically significant differences in the metabolic profile among uninfected I. scapularis nymphal

25 , compared with low perfusate PO2, perfusate metabolic profile analysis suggests that aerobic mechani

26 challenged, betaA1KO mice presented the same metabolic profile and beta-cell phenotype as the control

27 LSCs exhibit a unique metabolic profile and contain metabolically distinct sub

28 pose tissue has been shown before to improve metabolic profile and extend lifespan in various model o

29 l chicken can be differentiated based on the metabolic profile and multivariate analysis.

30 etes, have been shown to possess a favorable metabolic profile and to significantly reduce atheroscle

31 es were detected between the lines when leaf metabolic profiles and activities of the main enzymes in

32 e latter is key for a reliable comparison of metabolic profiles and for unknown biomarker identificat

33 NAD(+) repletion restores NAD(+) metabolic profiles and improves mitochondrial quality th

34 Alterations in hepatic metabolic profiles and nuclear receptor signaling were a

35 nuclear magnetic resonance spectroscopy for metabolic profiling and 16S ribosomal RNA sequencing to

36 These accelerate metabolic profiling and discovery platforms for next-gen

37 pectrometry (UHPLC-HRMS) method for salivary metabolic profiling and fingerprinting.

38 In summary, using a combination of metabolic profiling and GWAS, we identified FADS3 to be

39 ledge, this the first report of longitudinal metabolic profiling and identification of unique biomark

40 This method allowed for the metabolic profiling and the subsequent evaluation of the

41 stent reduction in fat mass, improvements in metabolic profile, and decreased adipose inflammation.

42 in white adipose tissue expressed a distinct metabolic profile, and white adipose tissue from previou

43 erall reduction in DNA methylation, aberrant metabolic profiles, and an increased expression of chemo

44 for each diet and identified the associated metabolic profiles, and then validated the models using

45 the reacquisition of a partial effector-like metabolic profile; and a gradual redistribution of aging

46 We used an untargeted global metabolic profiling approach for the discovery of novel

47 uclear magnetic resonance spectroscopy-based metabolic profiling approach with matching 16S microbiot

48 ophic lateral sclerosis we used a phenotypic metabolic profiling approach.

49 , metabolic changes in the NMR-based vaginal metabolic profile are able to discriminate the presence/

50 ss index (BMI) and offspring systemic cardio-metabolic profile are causal, via intrauterine mechanism

51 nt defense hormones and that the NAD-induced metabolic profiles are similar to those of defense-expre

52 In bone, metabolic profiles are tightly regulated and the loss of

53 Although large-scale applications of metabolic profiling are still novel, it seems likely tha

54 cluding the trained models and the simulated metabolic profiles, are also publicly available (Messa e

55 , metabolomics profiling revealed an altered metabolic profile arising from exposure.

56 The use of the identified metabolic profile as a predictor of mortality or surroga

57 reserves, and have an altered mitochondrial metabolic profile as displayed by increased mitochondria

58 ent rates, and were associated with a benign metabolic profile as evidenced by significantly lower le

59 patterns of cross-sectional association with metabolic profile as for parental pre-pregnancy BMI asso

60 ffect which may be associated with favorable metabolic profiles, as well as lower sympathetic activit

61 By global metabolic profiling, as well as genetic and chemical man

62 d by host cells, detection of changes in the metabolic profile associated with disease pathogenesis c

63 Our aims were to define the metabolic profile associated with higher blood adiponect

64 tebrate development, to elucidate changes in metabolic profiles associated with BMAA exposure.

65 unique metabolites and detecting changes in metabolic profiles associated with fruit maturation.

66 The capability of MAP to explore metabolic profiles at the single-cell level makes it a v

67 Extensive investigations included metabolic profile, autoantibody panel, infectious etiolo

68 distinct transcriptional states differing in metabolic profiles before converging to an alternative s

69 cally ill children, there would be different metabolic profiles between post-operative inflammation,

70 r variance with isotype usage, VDJ sequence, metabolic profile, biosynthesis activity, and signaling

71 tivity helps in the maintenance of a healthy metabolic profile both in humans and mice through molecu

72 After the induction of inflammatory and metabolic profiles, both M-CSF and GM-CSF generated comp

73 reporter on adopting an M2 tumor-associated metabolic profile by coupling luciferase expression to a

74 The two species showed a very different metabolic profile by Phenotype MicroArray(TM).

75 Metabolic profiling by GC-MS revealed distinct features

76 In this work, simultaneous targeted metabolic profiling by isotope dilution and non-targeted

77 our datasets support the notion that global metabolic profiling can be valuable for determining the

78 Together DRAM and DRAM-v provide critical metabolic profiling capabilities that decipher mechanism

79 The in situ metabolic profiling capacity of the proposed method toge

80 Although these two cohorts have different metabolic profiles, carriers in both cohorts had improve

81 We show that in response to eating, metabolic profiles change in quick, but distinct ways in

82 statistical data analysis indicated that the metabolic profile changed during ripening and that the m

83 Metabolic profile changes over time may imply responses

84 demonstrate that ATM from obese mice exhibit metabolic profiles characterized by elevated glycolysis

85 Targeted metabolic profiling characterized by complementary platf

86 onstrated that T(reg) cells exhibit a unique metabolic profile, characterized by an increase in mitoc

87 . hybridus, despite closed stomata, the leaf metabolic profiles combined with chlorophyll fluorescenc

88 (1)H NMR metabolic profile, combined with chemometric analysis, e

89 ts had a significantly different endothelial metabolic profile compared with controls.

90 auma patients have a significantly different metabolic profile compared with controls.

91 l sclerosis induced astrocytes have distinct metabolic profiles compared to controls and displayed a

92 show that S47 and P47 cells exhibit distinct metabolic profiles, controlled by their different redox

93 This altered metabolic profile correlates with a reduction in the siz

94 Differences in metabolic profile could be the result of differential ge

95 Metabolic profiling coupled with unbiased mass spectrome

96 We also detail how integration of metabolic profiling data with genetics can enhance drug

97 Gene expression and metabolic profiling demonstrate that the Tbx15(Hi) pread

98 bly, S1 and distal tubules exhibited similar metabolic profiles despite apparent differences in morph

99 differed between diets, with more favorable metabolic profiles detected after the WG diet.

100 Metabolic profiles did, however, discriminate the coliti

101 In conclusion, improvements in metabolic profile due to vitamin D supplementation is in

102 type with characteristic transcriptional and metabolic profiles, engineering the switch from mTORC1 t

103 A hierarchical clustering method of the metabolic profiles followed by Random Amplification of P

104 revious findings that suggest a very similar metabolic profile following both routes of drug administ

105 -MS data and identified parsimonious sets of metabolic profiles for distinguishing between cancer and

106 Further metabolic profiling for eight green tea tissues revealed

107 e key issues of study design and analyses of metabolic profiling for epidemiology.

108 ovel methodologies, including immuno-PCR and metabolic profiling for Lyme disease, are outlined.

109 ttern was confirmed with in silico generated metabolic profiles from a medium-size kinetic model of p

110 cells and in vivo and for the acquisition of metabolic profiles from human cancer cells of variable o

111 , we conducted mass spectrometry-based serum metabolic profiling from a model using humanized mice (h

112 cated that OA patients possess a respiratory metabolic profile fully divergent from those obtained in

113 Demographic data, metabolic profiles, hs-CRP (high-sensitivity C-reactive

114 Metabolic profiling identified reproducible signatures o

115 By a combination of metabolic profiling, imaging mass spectrometry, structur

116 he CB1-encoding gene had an overall improved metabolic profile in addition to reduced body weight and

117 etric analyses efficiently distinguished the metabolic profile in each storage period.

118 onal deconvolution of the cell-type-specific metabolic profile in neurons and astrocytes by convex op

119 al BMI was associated with an adverse cardio-metabolic profile in offspring.

120 ts of resuscitation duration on survival and metabolic profile in patients who undergo ECPR for refra

121 Mimicking aspects of this metabolic profile in PRs of wild-type mice by activation

122 is of cellular respiration indicated similar metabolic profile in the resulting iPSCs and ESCs, sugge

123 able effects of vitamin D supplementation on metabolic profile in Type 2 diabetes mellitus (T2DM) pat

124 cture, functional metagenome, and associated metabolic profiles in a sex-specific manner.

125 ses, we observed striking changes in hepatic metabolic profiles in Atp7b (-/-) mice, including increa

126 erved separation of global urinary and fecal metabolic profiles in critically ill compared with healt

127 of the largest cohorts to date examining the metabolic profiles in human milk comparing NW and OB wom

128 is associated with long-term risk of adverse metabolic profiles in offspring, and if so, whether this

129 Metabolic profiles in PAH are strongly related to surviv

130 red to a general hospital diet (GD) on serum metabolic profiles in patients (n = 18, >= 19 years old)

131 Previous studies have identified altered metabolic profiles in peripheral tissues associated with

132 glacialis reprograms its transcriptional and metabolic profiles in response to bacteria to secrete a

133 to an organism by observing the evolution of metabolic profiles in response to internal or external s

134 ious clinical phenotypes and high-throughput metabolic profiles in the Angiography and Genes Study (A

135 , which can be easily distinguished by their metabolic profiles in the aqueous phase.

136 ological and dietary risks, its residual and metabolic profiles in the fruit vegetable ecosystem stil

137 dy examines the effects of amifostine on the metabolic profiles in tissues of mice exposed to cobalt-

138 , the metabolomics results revealed that the metabolic profiles in treatment group were differentiate

139 which enables cell-type-specific and in situ metabolic profiling in complex tissue samples.

140 conventional 1D (1)H NMR as part of routine metabolic profiling in large data sets and show that app

141 Detailed metabolic profiling in large-scale epidemiologic studies

142 entary in vitro signaling assays and in vivo metabolic profiling in obese mice to investigate the eff

143 ometry (21TFTICR-MS) for in situ single-cell metabolic profiling in plant tissue.

144 ui 63 (MH63), we performed a widely targeted metabolic profiling in seeds during grain filling, matur

145 redicting post-MI LVEF and ISZ, we performed metabolic profiling in the GIPS-III randomized clinical

146 Cell-type-specific metabolic profiling in tissue with heterogeneous composi

147 signatures of the gut microbiome, including metabolic profiles, in preterm infants <34 weeks of gest

148 showed significant negative effects on avian metabolic profiles, in some cases after only two externa

149 In particular, we performed single-cell metabolic profiling including heterogeneity characteriza

150 ssue, the transgenic mice showed a healthier metabolic profile, including ameliorated fibrosis and in

151 changes in regulatory T cell and macrophage metabolic profiles, including generation of 2-hydroxyglu

152 cells exhibited cell-line dependent altered metabolic profiles, including significant changes in lac

153 cates that work stress is associated altered metabolic profile, increased systemic inflammation, and,

154 Metabolic profiling indicated increased energy expenditu

155 ntification of FLD and management of adverse metabolic profiles is critically important in HIV-HBV co

156 Here, we examined whether metabolic profiling is a feasible method of monitoring i

157 We discuss why quantitative metabolic profiling is becoming widespread in epidemiolo

158 A major purpose of exploratory metabolic profiling is for the identification of molecul

159 sponder) and for generation of an individual metabolic profile, leading to a better understanding of

160 in concentration associated with a favorable metabolic profile, lower prevalence rates of comorbiditi

161 cardiovascular risk exemplifies how detailed metabolic profiling may inform underlying aetiology via

162 8430 partially reversed transcriptional and metabolic profiles mediated by SIX1 overexpression and r

163 r-term effect of EGCG+RES supplementation on metabolic profile, mitochondrial capacity, fat oxidation

164 zing the causal effect of adiponectin in the metabolic profile of </=37 545 adults.

165 The present study aimed to investigate the metabolic profile of 3 genotypes of Conilon and compared

166 Here we report the metabolic profile of 300 tomato accessions (Solanum lyco

167 We evaluated the metabolic profile of a total of 394 patients' serum samp

168 of the biology of AAU, we characterized the metabolic profile of aqueous humor (AqH) of patients wit

169 emonstrate that FGF21 treatment improves the metabolic profile of Bscl2(-/-) lipodystrophic mice, par

170 These findings provide new insights into the metabolic profile of ILC2s and suggest that modulation o

171 " PGI ecotype was investigated to obtain the metabolic profile of its edible parts (blade leaves and

172 The metabolic profile of Lavado cocoa was characterized for

173 on their synthesis, this study evaluated the metabolic profile of leaves of olive cultivars (Arbequin

174 We investigated the metabolic profile of macrophages isolated from inflamed

175 ancy in the T-cell lineage and may alter the metabolic profile of malignant T cells.

176 The metabolic profile of Romeiko, Malvasia, Xinomavro, Sangi

177 this study, our goal was to characterize the metabolic profile of S. marcescens to provide insight fo

178 jective of this study was to investigate the metabolic profile of site-specific supragingival plaque

179 Instead, helminth infection altered the metabolic profile of the intestine, which directly enhan

180 cient mice in spite of the reduced oxidative metabolic profile of the periosteal cells.

181 est whether succinate modifies the (18)F-FDG metabolic profile of tumors, we performed in vitro and i

182 by GI helminths and the faecal microbial and metabolic profiles of a cohort of equine youngstock, pri

183 r feeding trial, we evaluated the effects on metabolic profiles of a low-glycemic whole-grain dietary

184 cancer, including the significantly altered metabolic profiles of cancer cells, represents a challen

185 Metabolic profiles of cells carrying the 5'UTR variant r

186 Metabolic profiles of co-cultures combined traits of bot

187 Our results indicate that the overall metabolic profiles of CSCs are distinct from non-stem ca

188 Lastly, metabolic profiles of each system show considerable over

189 lic network reconstruction and assessment of metabolic profiles of fecal samples might be used to ide

190 acterize the intracellular and extracellular metabolic profiles of four prostate cancer cell lines wi

191 MS) to image and chemically characterize the metabolic profiles of HGSC, BOT, and normal ovarian tiss

192 We have investigated the metabolic profiles of human breast cancer (BC) cell line

193 applied to the modeling of individual cancer metabolic profiles of hundreds to thousands of samples i

194 le to perform disease prioritization for the metabolic profiles of IEM patients even for diseases tha

195 In the current study, ex vivo metabolic profiles of image-guided tissue samples obtain

196 Metabolic profiles of mice were determined using metabol

197 The metabolic profiles of microtissues derived from normal o

198 ometry (LC-Q-TOF-MS) was utilized to acquire metabolic profiles of muscle, heart, and liver tissue fr

199 re significant differences in the NMR plasma metabolic profiles of NPC1 patients when compared to hea

200 We compared metabolic profiles of patients with those of age- and se

201 PCA revealed differences between the metabolic profiles of plaque treated with Arg or F.

202 ngitis (PSC) is a risk factor for CCA, serum metabolic profiles of PSC and CCA have also been compare

203 Investigating the metabolic profiles of solid sample materials with soluti

204 NMR spectroscopy data indicated that urinary metabolic profiles of the four diets were distinct.

205 he gut community has striking impacts on the metabolic profiles of the gut compartments and the hemol

206 uld not be determined unequivocally from the metabolic profiles of the hydrophilic metabolites; howev

207 apse imaging revealed dynamic changes in the metabolic profiles of the interstitium, urinary lumen, a

208 cant differences were identified between the metabolic profiles of the polymyxin-susceptible and -res

209 study to show substantial differences in the metabolic profiles of the polymyxin-susceptible and -res

210 The metabolic profiles of these comparative time-points indi

211 diversity, combined with the mostly unknown metabolic profiles of these new SCs, poses a big challen

212 We analyzed whole-plant performance and metabolic profiles of two geographically distinct eelgra

213 We hypothesised that metabolic profiles of urine samples developed under cont

214 METHODS AND We performed metabolic profiling of 231 lipoprotein and metabolite me

215 ss spectrometry and has been utilized in the metabolic profiling of a diverse range of biological mat

216 We performed untargeted global metabolic profiling of age-matched control and FXTAS mic

217 2D NMR spectroscopy was used for unambiguous metabolic profiling of albedo, flavedo and juice samples

218 Metabolic profiling of biological samples provides impor

219 Metabolic profiling of breath analysis involves processi

220 Metabolic profiling of cancer cells can play a vital rol

221 Metabolic profiling of cells in 2D culture systems often

222 try (UPLC-HRMS) analysis was carried out for metabolic profiling of chickpea leaves planted under con

223 cessing is a key bottleneck for 1H NMR-based metabolic profiling of complex biological mixtures, such

224 Hence, metabolic profiling of complex microtissues is necessary

225 Metabolic profiling of individuals with type 2 diabetes

226 Technologies enabling in situ metabolic profiling of living plant systems are invaluab

227 Here, we present a method for untargeted metabolic profiling of non-sterile rhizosphere soil.

228 ed in a complementary manner with the aim of metabolic profiling of plant leaves that have been colle

229 We performed metabolic profiling of plasma from presymptomatic HD tra

230 We performed metabolic profiling of plasma samples based on ultra-hig

231 Amongst children with presumptive TB, metabolic profiling of sera distinguished bacteriologica

232 Metabolic profiling of seven PA pathway mutants showed a

233 meters, we performed untargeted and targeted metabolic profiling of the rotenone PD model in a chroni

234 We conducted comprehensive (untargeted) metabolic profiling of volatile organic compounds (VOCs)

235 ion-mass spectrometry (LAESI-MS) for in situ metabolic profiling of wild-type nodules, nodules infect

236 In this report we performed metabolic profiling on a strain of Schizosaccharomyces p

237 METHODS AND We performed metabolic profiling on brain tissue samples from 43 indi

238 reatment ended, the differences in microbial metabolic profiles persisted into adulthood.

239 prising two classes of tumours with distinct metabolic profiles, prognosis and therapeutic susceptibi

240 serve a full metabolic cycle in C. albicans, metabolic profiling provides an avenue for rapid antimic

241 Progress in high-throughput metabolic profiling provides unprecedented opportunities

242 The rapid microbore metabolic profiling (RAMMP) approach was based on scalin

243 nding affinities, functional efficacies, and metabolic profiles revealed critical structural componen

244 Metabolic profiling revealed enhanced mitochondrial meta

245 Moreover, global metabolic profiling revealed extensive alterations in th

246 Metabolic profiling revealed that depletion of p62 in Ts

247 Metabolic profiling revealed that metabolites involved i

248 Intracellular metabolic profiling revealed that PknG is necessary for

249 signature of Ndfip1-deficient Treg cells and metabolic profiling reveals elevated glycolysis and incr

250 Metabolic profiling reveals that REDD1-deficient/RAS mut

251 6 weeks transverse aortic constriction, the metabolic profile reversed with impaired insulin sensiti

252 Metabolic profiles showed three stages in response to tr

253 RA classification using metabolic profiles shows a sensitivity of 91% and specif

254 onded to calcium channel blocker therapy had metabolic profiles similar to those of healthy control s

255 ily catabolize salivary protein and generate metabolic profiles similar to those seen in vivo.

256 essibility, infection-induced hypoxia, and a metabolic profile skewed toward aerobic glycolysis.

257 Additionally, metabolic profiling suggested that both glycolysis and t

258 found in both managed and wild dolphins; its metabolic profile suggests a capacity for denitrificatio

259 chnical advances in experimental systems and metabolic profiling technologies, we propose future dire

260 Formula-fed (FF) infants exhibit a different metabolic profile than breast-fed (BF) infants.

261 without alterations in NAE content, a unique metabolic profile that correlates with heightened insuli

262 l injection of THC in C57BL/6 mice modulates metabolic profiles that have previously been identified

263 oung and old mice demonstrated age-dependent metabolic profiles that may differentially poise platele

264 We performed comprehensive metabolic profiling to assess how circulating metabolite

265 metabolic engineering, isotope labeling and metabolic profiling to capture PFCs and demonstrate thei

266 Here we use a combination of genetics and metabolic profiling to characterize a pathway from the g

267 iferation and integrated gene expression and metabolic profiling to gain a better understanding of th

268 We used metabolic profiling to identify and validate uremic meta

269 We applied metabolic profiling to systematically interrogate these

270 Using unbiased and blinded metabolic profiling, TV-P improved myocardial energy sub

271 Untargeted and targeted metabolic profiling using 1H-nuclear magnetic resonance

272 RF using the refined metabolic profile was able to classify cases and control

273 His metabolic profile was normal.

274 Metabolic profiling was conducted by liquid chromatograp

275 ncing, Mtb proteome arrays (IgG and IgA) and metabolic profiling was performed.

276 SSAGE: By integration of transcriptional and metabolic profiles we identified pathways and hubs trans

277 experimental gradients with genome-resolved metabolic profiles, we link microorganisms lacking prior

278 Utilizing comprehensive metabolic profiling, we identify that steady induction o

279 Using metabolic profiling, we showed that loss of tRNA methyla

280 work will have value and utility in areas of metabolic profiling well beyond this exemplar.

281 Similar aberrations in the metabolic profile were observed already 10 years before

282 Her complete blood count and basic metabolic profile were unremarkable.

283 Metabolic profiles were analyzed by nuclear magnetic res

284 Metabolic profiles were assessed at baseline and after 3

285 Metabolic profiles were compared to identify compounds d

286 tal root length, and root tissue and exudate metabolic profiles were consistent across laboratories a

287 Metabolic profiles were distinguished in relation to ing

288 Differences in the protein and metabolic profiles were identified, both among treatment

289 Serum 25(OH)D and metabolic profiles were measured at baseline and after 1

290 1 and TP53 mutation-associated signaling and metabolic profiles were revealed, among which mutated CT

291 regeneration, and comprehensive genomic and metabolic profiling were conducted.

292 Plasma, urine, and CSF metabolic profiling were performed by coupled gas chroma

293 ic acid sequencing, Mtb proteome arrays, and metabolic profiling were performed.

294 ed tandem mass spectrometry (LC-MS/MS) based metabolic profiling were utilized to discover any signif

295 alterations to the gut microbiota and global metabolic profiles which may contribute to a depressive

296 hes, revealed a detailed, disease-associated metabolic profile with broad changes in multiple metabol

297 and gene analysis for changes in immune and metabolic profile with comparison to naive samples (n =

298 By combining metabolic profiling with a Drosophila genetic screen to

299 present substudy, we performed comprehensive metabolic profiling with multiple platforms (both nuclea

300 mals revealed significant differences in the metabolic profiles, with biochemical phenotypes indicati