ライフサイエンスコーパス: metabolic response

1 bolic response and three [12%] had a partial metabolic response).

2 onists into live mouse BAT and analyzing the metabolic response.

3 nical benefit and a lasting radiographic and metabolic response.

4 hagy, collectively indicative of a regulated metabolic response.

5 eductions from baseline were used to measure metabolic response.

6 risis, and triggers a marked region-specific metabolic response.

7 n, however, generates a complex hormonal and metabolic response.

8 play important roles in regulation of liver metabolic response.

9 onse, and three patients achieved a complete metabolic response.

10 nd imPERCIST accurately reflects the overall metabolic response.

11 ity, protein acetylation, and cellular lipid metabolic responses.

12 EPRS phosphorylation mediates S6K1-dependent metabolic responses.

13 llular copper, and impaired copper-dependent metabolic responses.

14 atory responses as well as the downregulated metabolic responses.

15 ot be compensated by any other AEF or anoxic metabolic responses.

16 ium-dependent stress signalling and adaptive metabolic responses.

17 a production, but not in modulating systemic metabolic responses.

18 synthesis, cytoskeletal rearrangements, and metabolic responses.

19 rm-dependent and -independent phenotypes and metabolic responses.

20 net anti-inflammatory and tissue-protective metabolic responses.

21 a1/Stat3 axis directs IL-13 signaling toward metabolic responses.

22 form for improved electrochemical studies of metabolic responses.

23 in brain and its relationship to peripheral metabolic responses.

24 influence the coordination of innate immune-metabolic responses.

25 pring were assessed for body composition and metabolic responses.

26 In patients with partial metabolic response, 2 of 4 isolated new lesions regresse

27 We evaluated the association between metabolic response after 2 cycles of neoadjuvant chemoth

28 The association of TMTV0 and AUC with metabolic response after 4 cycles, as well as progressio

29 dy aimed to define criteria for PET complete metabolic response after therapy, jointly analyzing a su

30 to compare the whole-body and muscle protein metabolic responses after the consumption of whole eggs

31 h perspectives on a fast method of observing metabolic responses against toxic agents.

32 es regardless of VHL status, suggesting that metabolic responses alone are not sufficient to explain

33 Associations between metabolic response and clinical outcomes were explored.

34 lower-calorie beverages can produce greater metabolic response and condition greater brain response

35 25% change in TLG (PERCIST) for both partial metabolic response and progressive metabolic disease, wh

36 ients, 22 (48%) patients achieved a complete metabolic response and six (13%) achieved a partial meta

37 ] 16 of 25 patients; 13 [52%] had a complete metabolic response and three [12%] had a partial metabol

38 abolomics was used to determine longitudinal metabolic responses and biosignatures in PTLDS and clini

39 In order to dissect metabolic responses and to identify promising metabolite

40 non-linear association between caloric load, metabolic response, and reinforcement potency, which is

41 ly therapeutic levels had at least a partial metabolic response, and three patients achieved a comple

42 ral blood to determine immune functionality, metabolic responses, and transcriptome profiles.

43 Current definitions of metabolic response are suboptimal and too simplistic.

44 ghly ordered interactions between immune and metabolic responses are evolutionarily conserved and par

45 nslational modification, gene expression and metabolic responses are induced.

46 ess is proportional to caloric load, greater metabolic responses are observed.

47 ion were among other factors correlated with metabolic response as revealed by PERCIST 1.0-defined de

48 ratory alkalosis impacts the global cerebral metabolic response as well as the cerebral pro-oxidation

49 er thanks to the prognostic value of partial metabolic response assessed by both PERCIST and Immuno-P

50 r, thanks to the prognostic value of partial metabolic response assessed by both PERCIST and immunoth

51 treated with ICIs, the findings suggest that metabolic response assessment has added prognostic value

52 We aimed to comprehensively reevaluate metabolic response assessment using accepted parameters,

53 t suggests the added prognostic value of the metabolic response assessment, potentially improving the

54 totally clear, but potential factors include metabolic responses associated with these disorders that

55 Complete metabolic response versus no metabolic response at PET/CT and complete response versu

56 imaging revealed an early and sustained host metabolic response at sites of infection that may reflec

57 as a partial metabolic response or complete metabolic response at the end of 8 cycles of treatment.

58 targeted therapy and correlated highly with metabolic responses at week 6 (R(2) = 0.81).

59 Individual best overall metabolic response (BOmR) was registered with both sets

60 We investigated the correlation between metabolic response by (18)F-FDG PET and objective respon

61 Metabolic response by (18)F-FDG PET predicts PFS and tim

62 After imatinib mesylate initiation, metabolic response by (18)F-FDG PET was documented earli

63 Metabolic response by (18)F-FDG PET/CT predicts overall

64 antibody titer, ASS1 methylation status, and metabolic response by 18F-fluorodeoxyglucose positron-em

65 No metabolic response by [(18)F]FDG-PET/CT scan at 2 weeks

66 Metabolic response by change in SUVpeak (7/17) and chang

67 Metabolic response by PERCIST (n = 44/73) was an indepen

68 l 23 (96%, 79-100%) also attained a complete metabolic response by PET.

69 of oxidative stress insults and measured the metabolic response by the nanosensor.

70 Conclusion: Our results suggest that early metabolic response can act as a surrogate marker of the

71 that the lowest concentration that elicits a metabolic response can be rapidly detected, while the me

72 In turn, these metabolic responses can affect the onset of insulin resi

73 study was to investigate whether these acute metabolic responses can also predict weight gain during

74 A complete metabolic response (cMR) was defined as SUVmax of <4.

75 week 1, there were 3 patients with complete metabolic response (CMR), 33 with partial metabolic resp

76 ifty-four patients (47%) achieved a complete metabolic response (CMR), defined as a completely negati

77 atients into 4 response categories: complete metabolic response (CMR), partial metabolic response (PM

78 Responses were categorized as complete metabolic response (CMR), partial metabolic response, st

79 ment group, 24 of 37 patients had a complete metabolic response (CMR).

80 Complete metabolic responses (CMR) were observed in 24 (75%) pati

81 show any abnormal (18)F-FDG uptake (complete metabolic response [CMR]) in 55 patients whereas 32 disp

82 s the standardized criterion of PET complete metabolic response, confirming the value of the DS for p

83 Metabolic response, defined by a significant reduction i

84 terindividual variability in weight loss and metabolic responses depends upon interactions between ge

85 function, in T cells, helps to ensure proper metabolic response during activation.

86 rformed to determine the prognostic value of metabolic response during induction chemotherapy followe

87 s characteristics of the systemic immune and metabolic response during severe polymicrobial sepsis.

88 Here, we detail the host immune and metabolic response during sickness and recovery in a mou

89 Results demonstrate dramatically distinct metabolic responses during cold exposure in BAT and WAT.

90 ng steady-state from non-steady-state muscle metabolic responses during whole-body exercise and (2) t

91 ulvestrant treatment induced a similar early metabolic response for both WT-ER and Y537S-ER tumors.

92 ions, mammals activate a complex multi-organ metabolic response for heat production.

93 line was used as a threshold for significant metabolic response for maximum SUV and, exploratively, f

94 The metabolic response from these entrapped nutrients may de

95 have their origins in feedback, homeostatic metabolic responses from the periphery.

96 ing and trans-acting eQTL for key immune and metabolic response genes and sepsis response networks.

97 PET evaluation revealed metabolic response (> 25% standardized uptake value decr

98 imaging after initial chemotherapy, complete metabolic response highly correlated with major patholog

99 els and bacterial strains according to their metabolic response in a multidimensional objective space

100 achieving redox balance and an anticipatory metabolic response in Mtb.

101 eity of factors leading to CFS, the cellular metabolic response in patients was homogeneous, statisti

102 ial and assessed the prognostic value of PET metabolic response in patients with chemotherapy-resista

103 Microscopy (FLIM) to quantify mitochondrial metabolic response in PCa cells by tracking auto-fluores

104 at HDL NP treatment activates a compensatory metabolic response in treated cells toward increased de

105 he PREDICT 1 study and assessed postprandial metabolic responses in a clinical setting and at home.

106 -2 may be involved in induction of selective metabolic responses in B. fragilis.

107 P inhibition and radiation induced a similar metabolic responses in BRCA-mutant HCC1937 cells, but no

108 ee Ca(2)(+) ([Ca(2)(+)]m) that trigger these metabolic responses in mitochondria in nerve terminals h

109 ral upregulation of activity-dependent brain metabolic responses in PD.

110 e report organ-specific NH(3) dose-dependent metabolic responses in several microfluidic bioartificia

111 This study investigated metabolic responses in Synechocystis sp. strain PCC 6803

112 ntestinal hormone that mediates postprandial metabolic responses in the liver.

113 Metabolic responses in the primary tumors were evident a

114 roRNA (miRNA) expression, and behavioral and metabolic responses in the progeny.

115 nges did not always equate to a proportional metabolic response, in depth correlation analysis identi

116 Insulin initiates diverse hepatic metabolic responses, including gluconeogenic suppression

117 ion of Mtb's ATP synthase triggers a complex metabolic response indicative of a specific hierarchy of

118 In addition, an immediate HSR-independent metabolic response is triggered, resulting in an accumul

119 n a system to dynamically visualize cellular metabolic responses mediated by GAD1, we monitored the c

120 was to prospectively evaluate the timing of metabolic response monitoring with (18)F-FDG PET of (neo

121 stable metabolic disease (n = 7) or partial metabolic response (n = 4).

122 s a novel microfluidic device to examine the metabolic response of a 2D layer of macrophage cells.

123 24 healthy individuals, to capture the acute metabolic response of a cereal breakfast (CB) and an egg

124 In this study, we investigated the metabolic response of adult mouse hearts expressing ssTn

125 ity, and physiological data that capture the metabolic response of H. pluvialis under nitrogen starva

126 This study characterised the metabolic response of HUVEC to the PPARbeta/delta agonis

127 However, it is unclear what determines the metabolic response of the cell to darkness and thus the

128 dant roles in mediating the hypertrophic and metabolic response of the heart to exercise.

129 Thus, we have identified a conserved metabolic response of tissues to ischaemia and reperfusi

130 To investigate the potential metabolic response of tomato plants to drought, we recon

131 t of the 5-PAHSA regioisomer in the adaptive metabolic response of white adipose tissue (WAT) to cold

132 The metabolic responses of bacteria to dynamic extracellular

133 the hypothesis that K(+) channels affect the metabolic responses of fat cells to nutrients.

134 nce that occludin levels largely control the metabolic responses of human pericytes to HIV.

135 r, soil, and water as well as monitoring the metabolic responses of living organisms to an ever chang

136 this study, we monitored the spatiotemporal metabolic responses of metabolically active Shewanella o

137 present study, we examined and compared the metabolic responses of nine soybean varieties grown unde

138 alt-stress conditions, and then compared the metabolic responses of the two species on different grow

139 A partial metabolic response on (18)F-FDG PET/CT scans was observe

140 s the overall response, defined as a partial metabolic response or complete metabolic response at the

141 no detrimental effects on fish performance, metabolic responses or the nutritional quality of the fi

142 tion to normalize CA19-9 or achieve complete metabolic response, or consideration of chemotherapeutic

143 ic response and six (13%) achieved a partial metabolic response (overall response rate 61% [95% CI 45

144 management correlated strongly with lack of metabolic response (P < 0.001) and non-KIT exon 11-mutat

145 mitochondria, play a role in setting up the metabolic response pattern of astrocytes.

146 te metabolic response (CMR), 33 with partial metabolic response (PMR), 6 with stable metabolic diseas

147 : complete metabolic response (CMR), partial metabolic response (PMR), stable metabolic disease (SMD)

148 glycemic events had greater inflammatory and metabolic responses, prevalence of sepsis, multiple orga

149 ORR of 70% (51% to 85%), with a 43% complete metabolic response rate per independent review.

150 We aimed to determine the metabolic response rate to vemurafenib in patients with

151 (18)F-FDG PET/CT metabolic response rates at weeks 2 and 6 were 71.6% and

152 mediastinum in up to 6 lesions, to determine metabolic response rates, indicated by negative posttrea

153 s the occurrence of differential patterns of metabolic responses specific to individual cues and berr

154 s complete metabolic response (CMR), partial metabolic response, stable metabolic disease, or progres

155 pite growth platform-specific phenotypes and metabolic responses suggests a considerable degree of ph

156 integrated with intestinal antimicrobial and metabolic responses that are controlled by type-3 innate

157 Acute psychological stress (PS) mobilizes metabolic responses that are of immediate benefit to the

158 1R have been investigated, the corresponding metabolic responses that could contribute to T1R patholo

159 adaptation to salinity requires cellular and metabolic responses that differ from short-term osmotic

160 radiation exposure leads to tissue specific metabolic responses that were corrected in part by treat

161 r receptors (NRs) that control endocrine and metabolic responses through transcriptional regulation.

162 Using metabolomics, we compared the acute metabolic response to 4 test breads between conventional

163 conclusions highlight the complexity of the metabolic response to a change in nitrogen nutrition.

164 se patterns identified by TOXcms signifies a metabolic response to a different protein target with a

165 n this study, comprehensive profiling of the metabolic response to a high-fat/high-sucrose diet (HFD)

166 mic analysis confirmed no change in cellular metabolic response to a range of osmolytes when treated

167 These findings provide a detailed map of the metabolic response to acute exercise in humans and ident

168 contributions of adipocyte lipolysis to the metabolic response to acute stress.

169 Thus, AAG plays an important role in the metabolic response to alkylation that could be exploited

170 In simple organisms like E.coli, the metabolic response to an external perturbation passes th

171 A group), whereas 20 patients had a complete metabolic response to ATT (non-RMA group).

172 is procedure influences the BAs pool and its metabolic response to bariatric surgeries is not known.

173 nt upon lipids as energy reserves to mount a metabolic response to biotic and abiotic challenges.

174 ducted to assess the predictive value of the metabolic response to BR compared with the response by I

175 This is the first report on the metabolic response to cardiac surgery in children.

176 olomics approach to characterize the initial metabolic response to cold exposure in multiple adipose

177 expenditure and BAT activation, but not the metabolic response to cold.

178 In this study, we compared the global metabolic response to CR of mice housed at 22 degrees C

179 ther human prostate tumors develop a similar metabolic response to different oncogenic drivers or a p

180 gy, we demonstrate that a shift in microbial metabolic response to different substrate inputs from pl

181 -sensing nuclear receptor that modulates the metabolic response to drugs and toxic agents.

182 rk provides insights into the physiology and metabolic response to environmental and genetic perturba

183 Sex difference in mouse metabolic response to erythropoietin.

184 Although the diet can affect the metabolic response to exercise, the contribution of a se

185 stand how this complex network regulates the metabolic response to fasting, we aimed at isolating the

186 ignalling and nutrient levels coordinate the metabolic response to feeding in the liver.

187 l models of liver regeneration implicate the metabolic response to hepatic insufficiency as an import

188 Recent data suggest that the metabolic response to hepatic insufficiency might be the

189 ne exposure (DNE) alters the ventilatory and metabolic response to hyperthermia in neonatal rats (pos

190 Understanding the mitochondrial metabolic response to hypoxia is key to understanding is

191 but the roles of specific cell types in the metabolic response to IL10 remain to be defined.

192 gree of overlap between these two species in metabolic response to infection but also showed Brachypo

193 As the metabolic response to injury was increasingly investigat

194 ral importance of adipocyte lipolysis in the metabolic response to injury.

195 r sensor leading to the evasion and adaptive metabolic response to insect defense peptides.

196 ension, muscle microvascular recruitment and metabolic response to insulin were determined.

197 nderstand the time course of hemodynamic and metabolic response to intraarterial (IA) mannitol infusi

198 ledge-based platform to elucidate S. aureus' metabolic response to its environment.

199 Using MRS, we monitored the brain metabolic response to lipopolysaccharides (LPS)-induced

200 The metabolic response to meal ingestion was markedly differ

201 intestinal tract bypass procedures alter the metabolic response to meal ingestion, by increasing earl

202 tions for rapid cellular-level assessment of metabolic response to molecular expression and drug acti

203 regulation, preventing the inhibition of the metabolic response to nutrient intake caused by deletion

204 to inflammation and plays a key role in the metabolic response to obesity, including insulin resista

205 ne if lean and obese rodents differ in their metabolic response to OVX-induced weight gain, and wheth

206 such as gluconeogenesis, lipogenesis, or the metabolic response to oxidative stress.

207 influence of maternal high-fat diet (HFD) on metabolic response to ozone was examined in Long-Evans r

208 nd activity intensity appear to modulate the metabolic response to physical activity.

209 r of protein quality control, influences the metabolic response to pressure overload by direct regula

210 cholecystectomy seems to alter the systemic metabolic response to RYGB.

211 ine the role of AMPK activation in the renal metabolic response to sepsis, the development of sepsis-

212 sent a composite biopattern of the pediatric metabolic response to septic shock and might be consider

213 To characterize cancer cell metabolic response to SFB, we measured oxygen consumptio

214 SUV(max)) approach-2 methods to assess early metabolic response to standard chemotherapy in DLBCL.

215 ensures maximal respiration capacity and the metabolic response to starvation.

216 indicate that polyamine catabolism is a core metabolic response to stress.

217 hese metabolites, might indicate a conserved metabolic response to stressors and, this data may be us

218 emic pipecolic acid accumulation is an early metabolic response to sub-optimal biotin status highligh

219 f living, decreased performance, and altered metabolic response to temperature stress-an indication o

220 accurately determine the ratio of the oxygen metabolic response to the hemodynamic response.

221 f sugar uptake by a single bacterium and its metabolic response to the sugar application with time.

222 s, the molecular pathogenesis of disease and metabolic response to therapeutic intervention has not b

223 (ATT), with some patients having a complete metabolic response to treatment whereas others have resi

224 the naturally occurring fluctuations in the metabolic response to U(VI) of plant cell cultures.

225 The metabolic responses to a carbohydrate/protein drink were

226 in a randomized crossover feeding trial the metabolic responses to a Mexican diet compared with a co

227 effect of baseline metabolome on the overall metabolic responses to berry intake.

228 emphasizes the importance of differences in metabolic responses to cancer treatments in different su

229 in system is a key component of the mood and metabolic responses to chronic psychosocial stress.

230 n microaerobic biofilm regions and influence metabolic responses to ciprofloxacin treatment.

231 Weight loss triggers important metabolic responses to conserve energy, especially via t

232 Our findings are consistent with adaptive metabolic responses to contrasting thermal regimes that

233 hereas S. moellendorffii mounts only limited metabolic responses to dehydration stress.

234 cate nutrient-sensing pathways fine tune the metabolic responses to dietary AAs in a highly conserved

235 ndings show that the FADS1 genotype modifies metabolic responses to dietary LA.

236 The metabolic responses to diets were assessed by measuring

237 treatments, suggesting perturbation-specific metabolic responses to DSW and DOM.

238 eurons in directing the thermoregulatory and metabolic responses to energy deficiency.

239 MPK) in skeletal muscle coordinates systemic metabolic responses to exercise(1).

240 the starvation hormone FGF21, which induces metabolic responses to fasting and stress responses thro

241 is a key hormone that regulates the adaptive metabolic responses to fasting.

242 otho-FGFR4 complex in hepatocytes to promote metabolic responses to feeding.

243 Metabolic responses to food influence risk of cardiometa

244 ntestinal epithelium, and help to coordinate metabolic responses to food ingestion.

245 tores may be a key factor in determining the metabolic responses to fructose ingestion, and saturatio

246 s illustrate how stress and depression alter metabolic responses to high-fat meals in ways that promo

247 depressive disorder (MDD) on obesity-related metabolic responses to high-fat meals.

248 ssociated mutations that deregulate cellular metabolic responses to hypoxia also reprogram carbon met

249 inducible factor 1 (HIF-1) mediates adaptive metabolic responses to hypoxia, including increased flux

250 cancer cells to reveal both known and novel metabolic responses to hypoxia.

251 scular action and significantly improved the metabolic responses to insulin in HFD male rats and thes

252 Sequential metabolic responses to intravenous (I.V.) glucose (I.V.

253 Sickness behaviors and metabolic responses to invading pathogens are common to

254 However, metabolic responses to local environmental conditions in

255 demands on the liver to adaptively regulate metabolic responses to maintain basic liver functions.

256 and computational pipeline to annotate leaf metabolic responses to Manduca sexta herbivory.

257 Additionally, diverse metabolic responses to medications among the volunteers

258 metabolism and the attenuated regional brain metabolic responses to MP were observed in female CA but

259 tic lobule, co-ordinating and amplifying the metabolic responses to multiple hormonal inputs.

260 nses could reflect a general upregulation of metabolic responses to neural activation.

261 riments with bioinformatic and RNA-seq data, metabolic responses to nitrate or NO and how nitrate and

262 However, evidence supporting similar metabolic responses to nutritional interventions is lack

263 substrates on physiological, biochemical and metabolic responses to pathogen infection.

264 asor analysis (FLIM/Phasor) and investigated metabolic responses to pressure of live cells from mesop

265 Here, metabolic responses to progressive environmental hypoxia

266 nd that FGF21 is required for behavioral and metabolic responses to protein restriction.

267 n malignant cells that must develop adaptive metabolic responses to reach their energetic and biosynt

268 Adaptive metabolic responses to sepsis can prevent bioenergetic f

269 We conclude that the metabolic responses to short-term fasting and COLD are a

270 alk between lipolysis and autophagy, two key metabolic responses to starvation, we screened the autop

271 in lipid metabolism may represent important metabolic responses to sub-acute exposure to environment

272 erries or nectars, optimize the postprandial metabolic responses to sucrose.

273 This observation and the delayed metabolic responses to the low-CO2 shift in ndhR, specif

274 We further applied this platform to study metabolic responses to traumatic brain injury in hippoca

275 To assess muscle protein metabolic responses to varied protein intakes during ED,

276 -elevation lakes will have larger or smaller metabolic responses to warming than higher latitude/elev

277 Based on enzyme activity assays and metabolic responses to waterlogging of the legume Lotus

278 T; secondary endpoints included feasibility, metabolic response, toxicity (CTCAE), local progression-

279 itical role in the induction of autophagy, a metabolic response typically associated with cell surviv

280 omparisons and characterization of the plant metabolic response under eight different light and/or te

281 n the present study, we explore the cerebral metabolic responses under extreme hypoxia and hypercapni

282 However, the metabolic response varies with the type of chemotherapy.

283 Complete metabolic response versus no metabolic response at PET/C

284 On a patient level, metabolic response was as follows: complete response, n

285 Metabolic response was assessed using 4 different IC har

286 Metabolic response was assessed using the change in tota

287 The metabolic response was classified on the basis of Europe

288 The metabolic response was cultivar specific; however green

289 A greater than 85% metabolic response was observed as early as days 1-7 in

290 Metabolic response was significantly associated with ove

291 Measuring the cells' immediate metabolic response, we find that central metabolites dra

292 To decipher the significance of this metabolic response, we found that depletion of PDK4 or a

293 saturated fatty acids (PUFAs) have different metabolic responses.We investigated whether the epigenom

294 on patient care, and the predictive value of metabolic response were assessed.

295 Metabolic responses were compared with study outcomes as

296 anisms, as well as growth platform-dependent metabolic responses were identified.

297 In the current study, adipose and liver metabolic responses were measured in the fasting state a

298 S6K1 has been implicated in a number of key metabolic responses, which contribute to obesity.

299 hematical model of resource availability and metabolic response within colony features.

300 The combination of myogenic, shear, CO2, and metabolic responses yields the best autoregulation (fact