ライフサイエンスコーパス: metabolic stress

1 g and maintaining systemic homeostasis under metabolic stress.

2 o modulate cellular processes in response to metabolic stress.

3 ynamic, changing in abundance in response to metabolic stress.

4 fails to function because of the fat-induced metabolic stress.

5 to sustain energy production under increased metabolic stress.

6 osphorylation.AMPK is involved in sensing of metabolic stress.

7 d chemokines in response to inflammatory and metabolic stress.

8 ling, reduced oxygen supply to the brain and metabolic stress.

9 major energy sensor for cells to respond to metabolic stress.

10 rmful stimuli such as pathogens, injury, and metabolic stress.

11 or protecting haematopoietic stem cells from metabolic stress.

12 tions by promoting cancer cell adaptation to metabolic stress.

13 eostasis across the circadian cycle or under metabolic stress.

14 pathways involved in neuronal adaptations to metabolic stress.

15 P1 inhibits cell death induced by unresolved metabolic stress.

16 inflammation in VAT and liver in response to metabolic stress.

17 sing CaO2, thereby relieving cerebral oxygen metabolic stress.

18 tributes to intrinsic cytoprotection against metabolic stress.

19 ciated with the level of fetal hypoxemia and metabolic stress.

20 ntial against ccRCC development by relieving metabolic stress.

21 sensor in the liver under lipid overload and metabolic stress.

22 cell survival under conditions of sustained metabolic stress.

23 assemblies, and link this modification to a metabolic stress.

24 utes to calcium homeostasis in situations of metabolic stress.

25 to maintain early hyperproliferation during metabolic stress.

26 decreased cell survival under conditions of metabolic stress.

27 mitochondrial biogenesis and as a sensor of metabolic stress.

28 regulation of energy balance in response to metabolic stress.

29 ing pathway is implicated in the response to metabolic stress.

30 h governs cell-autonomous adaptations during metabolic stress.

31 d their contributions to the pathogenesis of metabolic stress.

32 s play a role in the activation of PKR under metabolic stress.

33 ing targets to protect cells or tissues from metabolic stress.

34 ity glucose transporter, GLUT3, to withstand metabolic stress.

35 observed in cells subjected to oxidative or metabolic stress.

36 wn of TFII-I alters the cellular response to metabolic stress.

37 umor cell survival upon serum deprivation or metabolic stress.

38 r metastases must overcome hypoxia and other metabolic stress.

39 ting to beta-cell failure in the presence of metabolic stress.

40 mulation represented an adaptive response to metabolic stress.

41 s HSC lineage commitment under conditions of metabolic stress.

42 g the role of p73 to help cancer cells under metabolic stress.

43 adipose tissue expansion even under extreme metabolic stress.

44 eath often involves arrhythmias triggered by metabolic stress.

45 pH homeostasis of hippocampal neurons during metabolic stress.

46 pact the adaptation of beta cell function to metabolic stress.

47 e modes of metabolism enable cells to resist metabolic stress.

48 taining metabolic homeostasis in response to metabolic stress.

49 l effect of hepatic ABCA1 is decreased under metabolic stress.

50 o protect cells from the damaging effects of metabolic stress.

51 tream targets leading to cell survival under metabolic stress.

52 mal fetal growth and postnatal adaptation to metabolic stress.

53 as been shown to activate p53 in response to metabolic stress.

54 glucose deprivation that protects cells from metabolic stress.

55 ilitate fat storage in WAT, despite on-going metabolic stress.

56 NA damage as a survival program to cope with metabolic stress.

57 eficient cells unable to appropriately sense metabolic stress.

58 ynthetic activity in cancer cells exposed to metabolic stress.

59 n regulating responses to starvation-induced metabolic stress.

60 is hypothesis, Bax activation was induced by metabolic stress.

61 r layer of complexity to UPR activation upon metabolic stress.

62 licating c-MYC in the biological response to metabolic stress.

63 an essential mechanism protecting HSCs from metabolic stress.

64 s and autophagy pathways under conditions of metabolic stress.

65 ts glycolysis in adipose under conditions of metabolic stress.

66 nt genome-wide transcriptional control under metabolic stress.

67 ogramming regulates the cellular response to metabolic stress.

68 underlying intrinsic AGS cell resilience to metabolic stress.

69 s of depolarization have been observed under metabolic stress.

70 f AGS Atp5g1 that confers cell resilience to metabolic stress.

71 tomy (PHx), inducing acute proliferative and metabolic stress.

72 versity, which further sensitizes tumours to metabolic stress.

73 ession patterns of GLP-1R in mouse models of metabolic stress.

74 ponse that enables epigenetic persistence to metabolic stress.

75 m to maintain a population in the absence of metabolic stress.

76 and shifted from uncoupled to coupled under metabolic stress.

77 acellular adenosine indicates cell damage or metabolic stress.

78 ic bacteria and produced under conditions of metabolic stress.

79 these conditions represent or reflect minor metabolic stresses.

80 onucleoproteins that assemble in response to metabolic stresses.

81 pacity to increase glycolysis in response to metabolic stresses.

82 f cellular energy homeostasis in response to metabolic stresses.

83 ial for maintaining healthy conditions under metabolic stresses.

84 iRNA in pancreatic cancer cell adaptation to metabolic stresses.

85 of PTEN in transcriptional regulation under metabolic stress, a condition often developing in the tu

86 her, the results unveil a mechanism by which metabolic stresses activate AMPK, which, in turn, phosph

87 phosphorylated SMAD1/5 acts in synergy with metabolic stress-activated FOXO1 through formation of a

88 Under metabolic stress, activation of the AMP dependent Protei

89 Under metabolic stress, alanine is the main hepatic gluconeoge

90 iggered in RPE, we show that hypoxia-induced metabolic stress alone leads to photoreceptor atrophy.

91 n K2-upregulated glycolysis markedly induced metabolic stress, along with AMPK activation and mTORC1

92 In response to metabolic stress, AMPK maintains energy homeostasis by p

93 Upon metabolic stress, AMPK suppresses anabolic and promotes

94 locytomatosis oncogene (c-Myc), which led to metabolic stress and a defect in cell growth.

95 ion in glioma may be a response mechanism to metabolic stress and anticancer agents.

96 azolid suggested that its ability to trigger metabolic stress and apoptosis associated with tumor gro

97 pose tissue macrophages (ATMs) change during metabolic stress and are thought to contribute to metabo

98 cardiomyopathy.The mechanistic link between metabolic stress and associated cardiomyopathy is unknow

99 The data point to cross talk between metabolic stress and candidate genes at the beta-cell le

100 Metabolic stress and changes in nutrient levels modulate

101 tion, providing a potential new link between metabolic stress and development of B and T lymphocytes.

102 Although SIRT1 activity is regulated by metabolic stress and DNA damage, its function in these s

103 r processes critical for cell survival under metabolic stress and energy starvation is autophagy, a c

104 Here we show that beta-cell metabolic stress and hyperglycemia enhance the prolifera

105 persisters to ampicillin form from the same metabolic stress and identify the shared and unique elem

106 a physiological role of DNAJB3 in mitigating metabolic stress and improving glucose homeostasis and c

107 skeletal muscles from young mice exposed to metabolic stress and in muscles from healthy older human

108 utrient deficiency, and hypoxia resulting in metabolic stress and increased DNA damage.

109 te that ATM populations dynamically adapt to metabolic stress and inflammation, suggesting an importa

110 ata suggest that CAP antagonizes HFD-induced metabolic stress and inflammation, while it does not cau

111 cells (astrocytes, microglia), responding to metabolic stress and inflammatory stimuli, our study sug

112 , these results identify a critical role for metabolic stress and invasive bacterial pathogens in U b

113 hway is activated under common conditions of metabolic stress and may have a role in the pathogenesis

114 new study discovered a link between prenatal metabolic stress and nephron deficit via dysregulation o

115 promote beta cell survival in the context of metabolic stress and prevent the onset of type 2 diabete

116 ECM detachment induces metabolic stress and programmed cell death via anoikis.

117 HSP90 chaperones, including TRAP-1, overcome metabolic stress and promote tumor cell metastasis by li

118 nase (JNK) signaling pathway is activated by metabolic stress and promotes the development of metabol

119 esults indicate that AMPK protects LICs from metabolic stress and that combining AMPK inhibition with

120 l candidate genes governing the link between metabolic stress and the reproductive outcome of oocytes

121 eins into distinct compartments during acute metabolic stress and their retrieval during the recovery

122 findings reveal that Vitamin K2 could induce metabolic stress and trigger AMPK-dependent autophagic c

123 1 in modulating the cellular adaptability to metabolic stress and uncover a pivotal function of BAP1

124 echanism for understanding how patients with metabolic stress and/or diabetes are predisposed to deve

125 efits of dietary restriction and can counter metabolic stress, and 4E-BP1 disinhibition on mTORC1 rep

126 esis, increased synaptic aberrations, higher metabolic stress, and augmented inflammation.

127 ysical limitations, cardiovascular diseases, metabolic stress, and increased risk of mortality.

128 y MAGP1 is protective against the effects of metabolic stress, and its absence predisposes individual

129 lization of OXPHOS/glycolysis in response to metabolic stress, and mitochondrial function by measurin

130 ng glycolysis, sensing low-glutamine-induced metabolic stress, and promoting cellular adaptation to n

131 l to maintain adequate ATP production during metabolic stress, and reduced PTCD1 activity disrupts ne

132 hagy in vitro and in vivo, at rest and after metabolic stress, and that TAT-p27 inhibits apoptosis by

133 etween genetic risk factors for AD, cellular metabolic stress, and transcription/translation regulati

134 ular mechanisms of beta-cell compensation to metabolic stress are poorly understood.

135 undergo metabolic reprogramming to adapt to metabolic stress are still poorly understood.

136 filtrating immune cells typically experience metabolic stress as a result of the dysregulated metabol

137 are critical for OGT-mediated regulation of metabolic stress, as overexpression of stable HIF-1 or G

138 Metabolic stress, as well as several antidiabetic agents

139 pendent on AMPK beta-subunit myristoylation, metabolic stress associated with elevated AMP/ATP ratio,

140 risk in pediatric SCA by relieving cerebral metabolic stress at patient- and tissue-specific levels.

141 eostasis failure often entwine with those of metabolic stress at the cellular level.

142 bolism, which restores energy balance during metabolic stress both at the cellular and physiological

143 mass was normal under steady state and under metabolic stress by diet-induced obesity, but we observe

144 mass was normal under steady state and under metabolic stress by diet-induced obesity, but we observe

145 A that interacts with PKR after induction of metabolic stress by palmitic acid (PA) treatment.

146 on stress via Rev1-deficiency contributes to metabolic stress caused by compromized mitochondrial fun

147 f ERBB2 that protects cells from anoikis and metabolic stress caused by decreased matrix adhesion.

148 MPK inhibition synergized with physiological metabolic stress caused by dietary restriction and profo

149 The resulting metabolic stress caused by these mutations or caused by

150 Metabolic stress causes activation of the cJun NH(2)-ter

151 In preclinical trials toward metabolic stress, certain KL ADC can develop drug resist

152 nts receiving HU therapy have lower cerebral metabolic stress compared with patients not receiving di

153 brain-derived oligodendrocytes challenged by metabolic stress conditions (low nutrient/glucose).

154 ts of hyperglycemic and/or insulin-resistant metabolic stress conditions on human and mouse islets, w

155 derived OLs cultured under either optimal or metabolic stress conditions, deprivation of growth facto

156 c side chains, particularly arginines, under metabolic stress conditions.

157 gnaling pathway when administered under mild metabolic stress conditions.

158 ERK2 activation during metabolic stress contributes to changes in TCA cycle and

159 n is heterogeneous among beta-cells and that metabolic stress decreases the number of GLP-1R-positive

160 At this point, the nitro oxidative metabolic stress develops and its action in vivo over ti

161 We proposed that early metabolic stress driven by AMPK activation induces contr

162 ulated insulin secretion and the response to metabolic stress, e.g., glucolipotoxicity, in beta-cells

163 provide a novel molecular mechanism for how metabolic stress enhances invasion and metastasis.

164 ive effect of DDT required activation of the metabolic stress enzyme AMP-activated protein kinase (AM

165 Metabolic stress evokes significant penetration of comme

166 tes from lactating cows undergoing transient metabolic stress exhibit a different epigenetic profile

167 e, TBC1D5 shuttling to autophagosomes during metabolic stress facilitates retromer-dependent GLUT1 tr

168 by which other stimuli such as cytokines or metabolic stress function to stimulate NF-kappaB activat

169 The prevalence of cardiomyopathy from metabolic stress has increased dramatically; however, it

170 s (nitrosocysteine and hydrogen peroxide) or metabolic stress (high palmitate and high glucose) inact

171 cell-adaptive transcriptional program during metabolic stresses, highlighting Lmna gene processing as

172 amine how leukemia-initiating cells react to metabolic stress imposed by different tissue environment

173 ugh repression of DPYD expression, following metabolic stress imposed by nucleotide imbalance.

174 milation and biosynthesis in accord with the metabolic stress imposed by oxidative and nitrosative st

175 usage by PTEN null cells is increased under metabolic stress in contrast to PTEN-expressing cells.

176 It was hypothesized that maternal calcium metabolic stress in early pregnancy, rather than subopti

177 in this study highlights a potential role of metabolic stress in genomic instability and therapeutic

178 th-receptor activation or starvation-induced metabolic stress in human and murine macrophages increas

179 g protein eIF3d was activated in response to metabolic stress in human cells.

180 itochondrial function, higher sensitivity to metabolic stress in media containing galactose and azide

181 bition of de novo serine synthesis generates metabolic stress in MYCN-amplified neuroblastoma cells,

182 tects cells from oxidative, proteotoxic, and metabolic stress in normal cells, hyperactivation of NRF

183 offer neuroprotection by mitigating cerebral metabolic stress in patients with SCA, but not to the sa

184 tion, Gatm(c/c) colonocytes showed increased metabolic stress in response to DSS with higher levels o

185 ent colon cancer cells exposed to tumor-like metabolic stress in spheroid culture activated the meval

186 However, in mice PKR is also activated by metabolic stress in the absence of viral infection, and

187 he impact of RNS60 on the response of OLs to metabolic stress in vitro (glucose-nutrient deprivation,

188 ions, thus promoting CRC cell survival under metabolic stress in vitro and enhancing tumorigenesis in

189 equired for optimal insulin production under metabolic stress in vivo.

190 discovery rate (FDR) corrected p < 0.05) of metabolic stress, including enriched pathways related to

191 ive response to maintain cell survival under metabolic stresses, including androgen deprivation.

192 and that children experiencing the greatest metabolic stress, indicated by elevated oxygen extractio

193 Androgen receptor (AR) blockade and metabolic stress induce TNTs, but not in normal prostati

194 Here we show that metabolic stresses induce AMPK-mediated phosphorylation

195 did reduce the sensitivity of U2OS cells to metabolic stress induced by metformin, PML loss did not

196 t for tumorigenesis, due in part to profound metabolic stress induced by RAS activation.

197 essing keratinocytes are highly sensitive to metabolic stress induced by starvation or the antidiabet

198 Furthermore, increased metabolic stress induced in mice by feeding a high-fat d

199 Diverse metabolic stresses induced Ser473 phosphorylation of KAP

200 grity has therapeutic potential for treating metabolic stress-induced cardiomyopathy.The mechanistic

201 gulated in mouse and human beta cells during metabolic stress-induced compensation but downregulated

202 ession of MKP-1 protects macrophages against metabolic stress-induced dysfunction.

203 ponses, with male animals exhibiting greater metabolic stress-induced impairments than females.

204 c beta-cell replication and expansion during metabolic stress-induced insulin resistance with short-t

205 mitochondrial sirtuin activity, and prevents metabolic stress-induced non-alcoholic fatty liver disea

206 Mechanically, we show that BAP1 represses metabolic stress-induced UPR and cell death through acti

207 nd correlates with its ability to dampen the metabolic stress-induced UPR transcriptional network.

208 90 bp downstream from the initiation site of metabolic-stress-induced lncRNAs (mlonRNAs) in the promo

209 OR complex 1 (mTORC1) and sensitivity to the metabolic stress inducer phenformin.

210 Mtb's adaptive response to this metabolic stress involves a relief valve-like mechanism

211 Overcoming metabolic stress is a critical step in tumor growth.

212 pathologies and disease, to which prolonged metabolic stress is a major contributing factor.

213 The ability to sense metabolic stress is critical for successful cellular ada

214 glucose oxidation for ATP production during metabolic stress is pivotal for maintaining systemic ene

215 Sensitivity of HPV16 E7-expressing cells to metabolic stress is rescued by DINO depletion.

216 t potentially leads to PKR activation during metabolic stress is unknown.

217 mitter in the brain, but under conditions of metabolic stress it can accumulate to excitotoxic levels

218 Considering evidence of biomarkers of metabolic stress, it is of potential concern that our cu

219 During metabolic stress, LC3(+) autophagic compartments bind an

220 In this review, we detail how prolonged metabolic stress leads to adipose tissue dysfunction, in

221 expand pancreatic beta-cells in response to metabolic stress leads to excessive workload resulting i

222 In normal cells, such metabolic stress leads to inhibition of signaling throug

223 Here, we report that metabolic stress markedly enhances macroautophagy-indepe

224 tpartum oocytes suggest that early lactation metabolic stress may affect imprint acquisition, which c

225 notype and function and its dysregulation by metabolic stress may be a major contributor to atherogen

226 tive defense mechanism" and "insulin-induced metabolic stress" may provide explanation for some of th

227 er as excitotoxicity), brought on by chronic metabolic stress, may contribute to pancreatic beta-cell

228 We conclude that Myc is required for metabolic stress-mediated beta-cell expansion in young m

229 Metabolic stress modeled by anisomycin, thapsigargin, or

230 dia (ACM) on retinal and cortical neurons in metabolic stress models.

231 t that adaptation to nutritional changes and metabolic stress occurs through both de novo and pre-exi

232 ditional areas of metabolism impacted by the metabolic stress of 2AA in Salmonella enterica.

233 sponse (UPR) and angiogenesis to survive the metabolic stress of hypoxia.

234 in" primary immune mediated and "inside-out" metabolic stress of oligodendrocyte (OL) related mechani

235 ath response of HPV16 E7-expressing cells to metabolic stress or DNA damage.

236 prevents spurious activation in response to metabolic stress or low doses of TNF.

237 asis and protects the cell during periods of metabolic stress or nutrient deprivation.

238 origenic nutrients excess: "nutrient-induced metabolic stress" or, in brief, "nutri-stress."

239 Thus, death by metabolic stress parallels cellular attempts to survive.

240 combining AMPK inhibition with physiological metabolic stress potently suppresses AML by inducing oxi

241 h type 2 diabetes the destructive effects of metabolic stress predominate and beta cell death or dysf

242 g and to adapt beta-cell mass in response to metabolic stress, pregnancy hormones, and acute inductio

243 rived hormones to prepare the mother for the metabolic stress presented by fetal development and to e

244 Maternal calcium metabolic stress, rather than low calcium intake or insu

245 Metabolic stress reduces beta-cell sensitivity to GLP-1,

246 wn that CTT mitigates signatures of cerebral metabolic stress, reflected by elevated oxygen extractio

247 ted with the level of systemic hypoxemia and metabolic stress regardless of etiology.

248 e role of mutant p53 (mutp53) in response to metabolic stress remains unclear.

249 Through AMPK activation, metabolic stress represses HSF1, rendering cells vulnera

250 AGS ATP5G1 promotes metabolic stress resilience by modulating mitochondrial

251 promotes glucose-independent cell growth and metabolic stress resistance in human tumors.

252 MPK), a metabolic checkpoint kinase, confers metabolic stress resistance to leukemia-initiating cells

253 Thus, a metabolic stress response is established and propagated

254 e Escherichia coli small RNA SgrS controls a metabolic stress response that occurs upon accumulation

255 ics, we speculate that metformin may block a metabolic stress response that stimulates the inflammato

256 tivates AMPK and thereby interferes with the metabolic stress response.

257 t localization consistently were affected in metabolic stress responses, but their analysis also reve

258 Yet, accumulating metabolic stress resulting from as few as four rounds of

259 This mechanism is induced in response to metabolic stress resulting from glucose starvation or by

260 gramming during prostate carcinogenesis, the metabolic stress role in tumor survival, and the diagnos

261 The metabolic-stress sensing protein kinase GCN2 is a primar

262 AMP-activated protein kinase (AMPK) is a metabolic stress-sensing enzyme responsible for maintain

263 They find that inhibition of the metabolic stress sensor AMP-activated protein kinase (AM

264 ndings uncover a novel interplay between the metabolic stress sensor AMPK and the proteotoxic stress

265 tream, DRP1 activity regulated the essential metabolic stress sensor, AMP-activated protein kinase (A

266 The study shows that K-Ras is a target of a metabolic stress-signaling pathway that can be leveraged

267 godendrogliopathy has been linked with local metabolic stress, similar to the penumbra of ischemic/hy

268 no acid catabolism is especially relevant in metabolic stress situations (e.g. limited carbohydrate a

269 ogical interventions such as ARVs can induce metabolic stress, skewing the cell's immune response and

270 AMPK, a key sensor of metabolic stress stabilizes cell-cell junctions and main

271 llenge of hepatocytes with metformin-induced metabolic stress strengthened both AMPK activation and c

272 nockout-engineered heart tissue sensitive to metabolic stress such as serum withdrawal and restrictiv

273 insulin resistance that occur in response to metabolic stresses such as obesity and cytokine stimulat

274 However, in the presence of metabolic stress, such as in obesity, the resulting degr

275 lls and was associated with the induction of metabolic stresses, such as AAS or endoplasmic reticulum

276 Surprisingly, we discovered that metabolic stress suppresses the PSR.

277 Fzo1 proteolysis is activated by metabolic stress that arises from vacuole impairment, an

278 has been proposed as a marker of cumulative metabolic stress that can be assessed noninvasively by m

279 to intratumoral nutrient depletion, causing metabolic stress that has the potential to impact tumor

280 drocyte progenitor cells under conditions of metabolic stress that model the initial relapsing and su

281 hat Escherichia coli has evolved to minimize metabolic stress that results from the acquisition and u

282 ogical and pathological consequences of this metabolic stress, the adaptive responses that cells util

283 ration of hydrogen peroxide and induction of metabolic stress through enhanced DUOX expression and ra

284 f a growth state that provides resistance to metabolic stress through excess redox and energy product

285 patic inflammasome activation in response to metabolic stress through induction of lncRNA Gm15441.

286 can trigger the NLRP3 inflammasome connects metabolic stress to IL-1beta-mediated inflammation and p

287 Intriguingly, exposing neurons to extreme metabolic stress using oxygen/glucose deprivation (OGD)

288 When metabolic stress was induced by HFD, beta cells in contr

289 d OL spare respiratory capacity (SRC) when a metabolic stress was present.

290 Furthermore, indicators of metabolic stress were reflected by low amounts of ATP an

291 immune response, mitochondrial function and metabolic stress were significantly altered in the fligh

292 (36%, 38%, and 40%), as a metric of regional metabolic stress, were compared pre- and posttransfusion

293 effects of cell death, caused by hypoxia and metabolic stress, were largely studied in association wi

294 early universal cell death in the absence of metabolic stress, whereas expression of active Bax or NP

295 tegrated response to insulin stimulation and metabolic stress, which associates with reduced Tyr(P)(I

296 Yap loss triggers acute metabolic stress, which causes tumor regression while in

297 e donating optic nerve vulnerable to further metabolic stress, which could explain why local neurodeg

298 sensitized to cell death under conditions of metabolic stress, which in the case of E7 has been linke

299 ral for promoting cellular adaptation during metabolic stress while also functioning as a cellular ho

300 hat T. guizhouense undergoes a succession of metabolic stresses while F. oxysporum responded relative