ライフサイエンスコーパス: metabolically

1 which glial cells cannot fully support axons metabolically.

2 ophages (ATMs) must adapt phenotypically and metabolically.

3 not obese (MANO); and 801 participants were metabolically abnormal and obese (MAO).

4 abolically healthy but obese (MHO); 185 were metabolically abnormal but not obese (MANO); and 801 par

5 proportions of lean NAFLD patients who were metabolically abnormal or had elevated alanine aminotran

6 tes, hypertension, or hyperlipidemia defined metabolically abnormal patients.

7 es 2, 4, and 8 days after NL4-3 infection of metabolically activated and quiescent CD4 T cells (cultu

8 ose tissue macrophages to a pro-inflammatory metabolically activated phenotype (MMe) that alters the

9 ose tissue depots and on distinct classes of metabolically active adipocytes.

10 enotypically distinct intratumoral habitats: metabolically active and heterogeneous, enhancing and he

11 with tuberculosis contains subpopulations of metabolically active and inactive Mycobacterium tubercul

12 se to the functional unit of the kidney, are metabolically active and self-renew under glycolytic con

13 Unexpectedly, these cells appear to be metabolically active and show a transcriptome profile ve

14 habited by at least 30 halophilic species of metabolically active bacteria and archaea, unveiling a p

15 employed to monitor the deuterium uptake of metabolically active bacteria during antibiotic treatmen

16 robiology, to understand the contribution of metabolically active bacteria in fundamental processes t

17 ynamic type VI secretion system processes in metabolically active Bacteroides fragilis The ability to

18 was correlated with both local expansion of metabolically active bone marrow documented by FDG uptak

19 cell viability and screen susceptibility of metabolically active cells (E. coli, B. subtilis, Entero

20 is an organic-inorganic nanocomposite, where metabolically active cells are embedded within a matrix

21 The highly metabolically active cells of the renal tubule also pair

22 lostridioides difficile are transformed into metabolically active cells through the process of germin

23 enzyme in lipogenesis which is increased in metabolically active cells to meet nutrient requirements

24 ucture, as well as its relative abundance in metabolically active cells, bacterial 16S rRNA sequence

25 Community characterization of metabolically active communities via RNA sequencing has

26 Strikingly, kidneys became metabolically active during NMP, which could be enhanced

27 ion of anti-inflammatory factors, release of metabolically active enzymes, loss of proinflammatory cy

28 leading to calcific aortic valve disease are metabolically active for many years before and during th

29 design which maintains human cells alive and metabolically active for up to 72 h, and a semiautomated

30 In addition, this review highlights metabolically active growth factors and cytokines, which

31 birth, and by extension the fetal liver, was metabolically active in lipoprotein metabolism.

32 methyl-donor in liver methylation but is not metabolically active in the brain.

33 commonly used in PET/CT that is retained by metabolically active inflammatory cells in granulomas, b

34 ) values of metabolically inert feathers and metabolically active liver.

35 Alveolar type 2 (AT2) cells represent a metabolically active lung cell population important for

36 The human gut is inhabited by a complex and metabolically active microbial ecosystem.

37 temporally complex paradigms, with a role of metabolically active oligodendrocytes in cortical inform

38 s needed to establish whether Malassezia are metabolically active oral commensals.

39 taneous adipose tissue, which is the largest metabolically active organ in the human body and is cons

40 The lung is often overlooked as a metabolically active organ, yet biochemical studies have

41 r the evaluation of substrate utilization in metabolically active organs, such as the heart and brown

42 increased oxidative phosphorylation or high metabolically active phenotype.

43 ellular entities are generally viewed as non-metabolically active spore-like agents that await furthe

44 s was evident, with dividing Pg suggesting a metabolically active state during invasion.

45 of cellulose to maintain a slow-replicating, metabolically active state.

46 ria on and near dead fungal hyphae were more metabolically active than those far from hyphae.

47 Brown adipose tissue (BAT) is highly metabolically active tissue that dissipates energy via U

48 In metabolically active tissues (liver, muscle, fat, heart,

49 suggesting they are present at low levels in metabolically active tissues and are not exclusive to in

50 However, its role in metabolically active tissues that precipitate T2D develo

51 lammatory polarization of macrophages within metabolically active tissues, such as adipose tissue, mu

52 station in other parasites, whereas EVs from metabolically active trophozoites impeded encystation.

53 Baseline whole-body metabolically active tumor volume (WB-MATV) measured by

54 Such PAM have amoeboid morphology, are metabolically active, and phagocytose newly formed oligo

55 Starved cells lacking Grh1 are metabolically active, but defective in their ability to

56 stly Foxp3(+) regulatory T (T reg) cells and metabolically active, highly proliferative conventional

57 adaptation of housekeeping functions from a metabolically active, proliferative state toward quiesce

58 roximal tubular epithelial cells, are highly metabolically active, relying on fatty acids to meet the

59 at bacteria inhabiting the mucosal niche are metabolically active.

60 Traditional methods for detection of metabolically-active bacterial cells, while effective, r

61 l culture media) to cells within cell-dense, metabolically-active biofabricated tissues is required t

62 eq) of subcutaneous adipose tissue defined a metabolically-active mature adipocyte subtype characteri

63 transport enables local protein synthesis at metabolically-active sites distant from the nucleus.

64 Salmonella Typhimurium is metabolically adaptable and can harvest energy by anaero

65 are mislocalized from the gut microbiota and metabolically adapted to the MAT contribute to the "cree

66 small population of infected cells that are metabolically altered and characterized by mitochondrial

67 These data demonstrate that CD8+ T cells are metabolically altered by exercise in a manner that acts

68 ulation is offloaded from hypoxic cells onto metabolically altruistic normoxic neighbors.

69 Here, we show that Bacteroides species are metabolically and energetically robust and do not mount

70 mes are fundamentally wired informationally, metabolically, and genetically.

71 To assess the metabolically beneficial effects of fenugreek (Trigonell

72 Brown adipose tissue is a metabolically beneficial organ capable of dissipating ch

73 lated in various environmental conditions to metabolically benefit cancer progression.

74 s thereby sustaining fatty acid oxidation in metabolically challenging metastatic environments.

75 Mice were metabolically characterized on POD 30-32 and euthanized

76 II knockout [mMHCII(-/-)]) were created and metabolically characterized.

77 ks of age, mice were then phenotypically and metabolically characterized.

78 keleton, flowers may rely predominantly on a metabolically cheaper, hydrostatic skeleton to keep thei

79 Understanding how microbes metabolically communicate with their hosts will provide

80 and could be redifferentiated in vitro into metabolically competent cells that supported the replica

81 dine and that response was modulated using a metabolically competent liver module that converted terf

82 for respiration and pyrimidine synthesis in metabolically compromised environments.

83 cations for the investigation of PLGA use in metabolically-compromised clinical and experimental sett

84 Metabolically-constrained modelling of food-web dynamics

85 Chemokine-controlled NADPH oxidases and metabolically controlled mitochondrial sources of H2O2 a

86 Tumor cells metabolically coordinate or compete with their "neighbor

87 erred, asymmetric walking patterns were less metabolically costly than symmetric walking patterns Whe

88 be established where the mutant strains are metabolically coupled.

89 Early-postpartum cows were metabolically deficient with a significantly lower energ

90 idence indicates that synaptic plasticity is metabolically demanding as well.

91 rvous system (SNS) activation in response to metabolically demanding emergencies.

92 Neuronal transmission is a metabolically demanding process in which ATP consumption

93 than particular cell types or cytokines, in metabolically demanding processes such as autoimmunity,

94 Fast growth and thermal stress are metabolically demanding, and both factors can increase o

95 ctory, comprising three distinct stages that metabolically describe the adaptation of the fungus to d

96 Using a glutamine antagonist, we metabolically dismantled the immunosuppressive microenvi

97 eveloping in low glucose, cells arrange into metabolically disparate cell groups.

98 Mycotypes were also associated with metabolically distinct bacteria indicative of divergent

99 sent a model for the eukaryotic pathway with metabolically distinct pools of PC, suggesting an underl

100 of the composite model structure identifies metabolically distinct sub-populations within a tumor ty

101 hibit a unique metabolic profile and contain metabolically distinct subpopulations.

102 en populations of mitochondria isolated from metabolically distinct tissues.

103 omputer modeling, female and male livers are metabolically distinct with unique regulators modulating

104 own in soil extract were morphologically and metabolically distinct, with root hairs four times longe

105 hylator phenotype-associated (CIMP) RCCs and metabolically divergent chRCCs, and new biomarkers of po

106 n, we observed 2 Tc17 cell subsets that were metabolically divergent, were developmentally related, a

107 indings indicate that Prevotella species are metabolically diverse and overall not cytotoxic or overt

108 demonstrate the applicability of DRAM across metabolically diverse genomes, we evaluated DRAM perform

109 s to study the function of taxonomically and metabolically diverse microbiomes are limited by their d

110 xterior environments of phylogenetically and metabolically diverse microorganisms.

111 rmone therapy (HT)-naive cells or HT-treated metabolically dormant populations with CAF-derived mtDNA

112 allows starving cells to differentiate into metabolically dormant spores that can survive extreme co

113 Our findings suggest a trade-off between metabolically-driven energy conservation during winter a

114 Fibrotic subcutaneous adipose tissue is metabolically dysfunctional and loses its capacity to ex

115 obesity the adipocyte progressively becomes metabolically dysfunctional due to its acquisition of fi

116 elevated GDF15 and FGF21 levels, indicating metabolically dysfunctional fat.

117 and assistive devices that target the least metabolically economic part of the gait cycle.

118 indicates that larger hummingbirds are less metabolically efficient than smaller hummingbirds.

119 ethods open new, cheaper, and faster ways to metabolically engineer microorganisms.

120 Our goal is to metabolically engineer Nicotiana benthamiana using montb

121 technology in the regulatory assessment for metabolically engineered biotech crops.

122 kidney disease, and fermentation products of metabolically engineered cyanobacteria.

123 d an enzymatic/fermentative bioprocess using metabolically engineered Escherichia coli The pretreatme

124 le Caldicellulosiruptor bescii that has been metabolically engineered to shift its fermentation produ

125 ases the yield of beta-ionone synthesized by metabolically engineered yeast.

126 CT1-4 catalyze the transmembrane movement of metabolically essential monocarboxylates and have been t

127 As a result, instead of employing a metabolically expensive but durable carbon (C)-based ske

128 lls persist in dormancy, how they manage the metabolically expensive process of cytokine production t

129 find that intestinal disease tolerance is a metabolically expensive trait, whose expression is restr

130 s that these spectacular aerial displays are metabolically expensive.

131 at distribution caused elevated ACR, while a metabolically "favorable adiposity" phenotype lowered AC

132 and the pentose phosphate pathway, MPhi were metabolically flexible enough that inflammatory cytokine

133 Macrophages (MPhis) are heterogeneous and metabolically flexible, with metabolism strongly affecti

134 studied and it is unknown if ALS MNs differ metabolically from healthy MNs.

135 stoichiometric and structural remodelling of metabolically functional Pdu MCPs.

136 Metabolically generated changes in the intracellular con

137 MI in adolescence (PWV 5.8 m/s [5.7-5.9] for metabolically healthy and 5.9 m/s [5.6-6.1] for metaboli

138 normal FMI throughout (5.7 m/s [5.7-5.8] for metabolically healthy and 5.9 m/s [5.8-5.9] for metaboli

139 e and obesity status: 1378 participants were metabolically healthy and non-obese (MHNO); 826 were met

140 ns and plays an integral role in maintaining metabolically healthy AT function.

141 cally healthy and non-obese (MHNO); 826 were metabolically healthy but obese (MHO); 185 were metaboli

142 tified by adiposity and insulin sensitivity: metabolically healthy lean (MHL; n = 11), metabolically

143 ntly greater risk (by 50-300%) compared with metabolically healthy lean subjects.

144 r risk of psoriasis incidence as compared to metabolically healthy non-obese subjects.

145 Compared with metabolically healthy normal weight (MHN), baseline MHO

146 y: metabolically healthy lean (MHL; n = 11), metabolically healthy obese (MHO; n = 15), and metabolic

147 This study examined the associations among metabolically healthy obese individuals and 4 different

148 Metabolically healthy obesity (MHO) and its transition t

149 ere is no universally accepted definition of metabolically healthy obesity (MHO).

150 Metabolically healthy obesity needs to be treated, and t

151 Metabolically healthy obesity refers to an obesity pheno

152 stiffness (PWV 6.0 m/s [95% CI 5.9-6.0] for metabolically healthy participants and 6.2 m/s [5.9-6.4]

153 ffects many of the physiological traits of a metabolically healthy phenotype); however, weight loss i

154 deposition are key physiological traits of a metabolically healthy phenotype.

155 This indicated that young, metabolically healthy subjects can at least temporarily

156 sferred from patients with T2DM but not from metabolically healthy subjects caused insulin resistance

157 ptibility to obesity, we performed a GWAS on metabolically healthy thin individuals (lowest 6(th) per

158 I] 2.00-2.47, p < 0.001) and transition from metabolically healthy to unhealthy status (HR 1.53, 1.34

159 , as ~50% of these subjects will cease being metabolically healthy within ~10 y.

160 Healthy WAT expansion, observed in the "metabolically healthy" obese, is generally associated wi

161 merous people reported as having MHO are not metabolically healthy, but simply have fewer metabolic a

162 About 35% of all subjects with obesity are metabolically healthy.

163 fects of excess body fat and are considered "metabolically healthy." However, there is no universally

164 This demonstrates precisely how metabolically heterogeneous beta-cell populations intera

165 l of autoimmune disease are functionally and metabolically heterogeneous; they contain a subset with

166 The TME, however, can be metabolically hostile due to insufficient vascular excha

167 rin beta7(-) mice that lack natural IELs are metabolically hyperactive and, when fed a high-fat and h

168 reveal that C. albicans tetraploid cells are metabolically hyperactive on this medium with higher rat

169 uxleyi intracellular DMSP did not respond to metabolically imbalanced conditions, while Thalassiosira

170 xidative capacity, which further compromises metabolically impaired C3KO muscles and thus is unlikely

171 mitochondria into chloramphenicol-sensitive, metabolically impaired rho+ mouse cybrid cells.

172 ts suggest that exogenous mtDNA retention in metabolically impaired rho+ recipients depends on the de

173 ction, although exogenous mtDNA is lost from metabolically impaired, mtDNA-intact (rho+) cells.

174 stable isotopes of carbon, RNA sequencing of metabolically important enzymes, and immunolocalization

175 While proteins containing metabolically important functional groups such as carboh

176 CYP2A enzymes metabolically inactivate nicotine and activate tobacco-d

177 C-secreted cytokines; however, apoptotic and metabolically inactivated MSCs have more recently been s

178 erogeneous, enhancing and heterogeneous, and metabolically inactive and homogeneous.

179 would avoid costly interventions related to metabolically inactive microorganisms.

180 is hindered by the presence of biofilms and metabolically inactive persisters.

181 aracterizes the hybrid metabolic state and a metabolically inactive state where cells have low activi

182 atable trehalose monomycolate analogues that metabolically incorporate into the mycomembrane in live

183 HCs have been thought to be electrically and metabolically independent from each other.

184 ids, nitrite treatment reduced the degree of metabolically induced steatosis (i.e., high glucose, ins

185 f1(-/-) mice are lean, obesity-resistant and metabolically inefficient.

186 ured hydrogen isotope (delta(2) H) values of metabolically inert feathers and metabolically active li

187 In this study, we show that the T2D heart is metabolically inflexible and almost exclusively dependen

188 Imaging of metabolically labeled cell surface glycans underlined th

189 Here we present single-cell metabolically labeled new RNA tagging sequencing (scNT-s

190 nto smooth muscle cells (SMCs) that had been metabolically labeled with [(15)N]choline.

191 Mice were metabolically labeled with a specially formulated chow c

192 used to measure protein synthesis depend on metabolically labeling large numbers of cells with radio

193 ) to convert fluorocytosine to fluorouracil, metabolically labeling nascent RNA in rare cell populati

194 involving microvesicle particles by which a metabolically labile bioactive lipid can travel from cel

195 a phosphinate ester and substitution of the metabolically labile naphthalene with a haloaryl substit

196 llus endospores, Streptomyces exospores, and metabolically latent Mycobacterium cells.

197 PsA more often exhibits an increased risk of metabolically linked comorbidities such as obesity, insu

198 l effects of storing excess triglycerides in metabolically low-risk depots.

199 Clear evidence now implicates a metabolically mediated response to leaf water status ('h

200 nce of perchlorate, and (5) all species were metabolically most active in the phyllosilicate-containi

201 The retina and optic nerve are among the metabolically most active structures in the human body a

202 ly resistant to diet-induced weight gain and metabolically normal despite increased food intake, comp

203 Metabolically obese normal weight (MONW) individuals are

204 HRSP rats as a unique model for studying the metabolically obese normal weight (MONW) phenotype in hu

205 esis of one of the most densely modified and metabolically obscure ribosome-derived molecules found i

206 d macrophages use the alveolar epithelium to metabolically process myeloid cells and advance antibact

207 investigate this, we collected oocytes from metabolically-profiled cows at early- and mid-postpartum

208 ctate production, whereas IL-21 maintained a metabolically quiescent state dependent on oxidative pho

209 Metabolically quiescent T cells circulate throughout the

210 galactose treatment of PGM1-CDG fibroblasts metabolically re-wires their sugar metabolism, and as su

211 ugh not at 4 degrees C, (3) M. mazei was not metabolically reactivated through deliquescence, (4) non

212 SCFAs metabolically regulate T cells and change the phenotype

213 This metabolically regulated collagen modification renders th

214 es involved in glucosinolate biosynthesis, a metabolically related route that produces defense compou

215 olic syndrome (MetS) represents a cluster of metabolically related symptoms such as obesity, hyperten

216 KK2 and demonstrate its utility for treating metabolically-related hepatic disease.

217 ation, storage and fate of dietary sugars in metabolically relevant tissues is fundamental to underst

218 M displayed alterations in the expression of metabolically-relevant neuropeptides in the hypothalamus

219 ation plasma, our long duration CA rat model metabolically replicates human disease and is a suitable

220 al samples and identified tissue-restricted, metabolically repressed cytotoxic T cells in human color

221 human tissues, which indicated exclusion of metabolically repressed immune cells from the tumor-immu

222 phages engage alveolar epithelial signals to metabolically reprogram monocytes for antibacterial infl

223 wiring to increase the uptake of glucose and metabolically reprogram to favor aerobic glycolysis over

224 The molecular taxonomy of the metabolically reprogrammed RA T cells includes glycolyti

225 Leptin metabolically reprogrammed T cells in vitro, and melanom

226 Likewise, cells can be metabolically reprogrammed to promote either their short

227 Furthermore, liposomal delivery of a metabolically resistant 5-InsP(7) analog into wild-type

228 -dependent manner by liposomal delivery of a metabolically resistant methylene bisphosphonate (PCP) a

229 sent over the last 50 y are behaviorally and metabolically resistant to sequestered benzoxazinoids an

230 to decode due to the absence of a scalable, metabolically resolved, annotation software.

231 FAM19A1, a brain-enriched and metabolically responsive neurokine, regulates food intak

232 genomic aging, and later in adulthood unlock metabolically restricted epigenetic reprogramming to dri

233 NRF2 activation metabolically rewired and elevated pathways involved in

234 uding double alkylation, the installation of metabolically robust deuterated methyl groups, and tande

235 at is less well-studied is how resting cells metabolically shift from an ATP-producing catabolic meta

236 stly be prevalent among phylogenetically and metabolically similar species.

237 probability of antagonism increased the more metabolically similar the strains were.

238 with less 24EE decrease during fasting (more metabolically spendthrift individuals) gained less weigh

239 ides can be safely applied for the design of metabolically stabilized therapeutic GalNAc-siRNAs with

240 Several metabolically stable 2-arylvinylquinolines are identifie

241 initiated, to construct a novel platform of metabolically stable A. terreus for sustainable Taxol pr

242 In this work, we report potent, metabolically stable analogs that result from replacing

243 DCZ represents a potent, selective, metabolically stable and fast-acting DREADD agonist with

244 tructural biology, provided a high affinity, metabolically stable Bicycle with improved physicochemic

245 F(2) H) is considered to be a lipophilic and metabolically stable bioisostere of an amino (NH(2) ) gr

246 single 1,4-disubstituted 1,2,3-triazoles as metabolically stable bioisosteres of trans-amide bonds (

247 roduced 1,4-disubstituted 1,2,3-triazoles as metabolically stable bioisosteres to replace labile amid

248 These metabolically stable compounds showed a further increase

249 l to chemists in the pursuit of synthesizing metabolically stable compounds.

250 ally, we report a pharmacokinetic-optimized, metabolically stable derivative that induced growth dela

251 Administration of a metabolically stable Gboxin analogue inhibits glioblasto

252 JR14a was metabolically stable in rat plasma and in rat liver micr

253 erivative 11a was identified as a potent and metabolically stable influenza inhibitor.

254 lenophene residues as spine motifs, yielding metabolically stable inhibitors with high potency on enz

255 ment of a highly potent, cell-permeable, and metabolically stable peptidyl inhibitor, CNI103, which s

256 Here, we investigated the potential use of a metabolically stable spermine mimetic, (R,R)-1,12-dimeth

257 euticals, one of which is substantially more metabolically stable than its commercial progenitor.

258 t (IC(50) = 4.10 +/- 1.2 nM), selective, and metabolically stable TRPM8 antagonist.

259 s of novel antibacterial compounds is highly metabolically stable with a biological half-life of 10.5

260 ther bacterial species and eukaryotic cells, metabolically stable, and apparently not susceptible to

261 high-throughput screening hit 8 to a potent, metabolically stable, and orally bioavailable diazaspiro

262 Compound 8 is a highly potent, selective, metabolically stable, and soluble compound suitable for

263 hey proved efficient in target binding, were metabolically stable, nontoxic, selective, and potent in

264 ial respiration and promote healthy aging in metabolically stressed mammals.

265 in oligodendrocytes and myelin is needed to metabolically support axonal function, the findings sugg

266 checkpoint receptor-mediated tolerance, and metabolically support sustained T-cell activation.

267 ces reperfusion injury, prevents oedema, and metabolically supports the energy requirements of the br

268 As a result, metabolically targeted therapies could become important

269 Bypassing metabolically the adenosine deaminase defect by inosine

270 ulated in a scmR deletion mutant (DeltascmR) Metabolically, the DeltascmR strain displays a hyperacti

271 Metabolically, the stiffest insoles increased energy cos

272 kers forage outside the nest, and gain water metabolically through seeds collected in foraging trips.

273 gger macrophages to engulf virus-infected or metabolically traumatized, but still living, cells, and

274 TGF-beta1 induces microglia to metabolically tune from a glycolytic phenotype (M1) to a

275 lar cell proliferation in both depots in the metabolically unfavorable phenotype.

276 We classified participants as being metabolically unhealthy if they had three or more of the

277 The metabolically unhealthy non-obese (MUNO) subjects (hazar

278 tabolically healthy obese (MHO; n = 15), and metabolically unhealthy obese (MUO; n = 20).RESULTSAT pO

279 95% confidence interval [CI], 1.22-1.37) and metabolically unhealthy obese subjects (MUO; HR, 1.33; 9

280 ewer metabolic abnormalities than those with metabolically unhealthy obesity (MUO).

281 at accumulation is a primary risk factor for metabolically unhealthy obesity and related diseases.

282 Stable metabolically unhealthy overweight or obesity (MUOO) (HR

283 althy participants and 6.2 m/s [5.9-6.4] for metabolically unhealthy participants).

284 st 40% of those participants transitioned to metabolically unhealthy status.

285 tes and cardiovascular disease compared with metabolically unhealthy subjects with obesity, but they

286 abolically healthy and 5.9 m/s [5.6-6.1] for metabolically unhealthy) had comparable PWV to those who

287 abolically healthy and 5.9 m/s [5.8-5.9] for metabolically unhealthy).

288 al of the assumption that, because sodium is metabolically unimportant to most plants, it is of littl

289 ported a novel SAR campaign that converted a metabolically unstable series of mu-opioid receptor (MOR

290 thogenic species within an extended genus of metabolically versatile Actinobacteria of considerable b

291 on identifying micro-organisms that are both metabolically versatile and engineerable.

292 ed methods for engineering the genome of the metabolically versatile and naturally transformable bact

293 Here, we leverage the facile genetics of the metabolically versatile bacterium Acinetobacter baylyi A

294 This metabolically versatile bacterium can cause a wide range

295 metabolism in Rhodopseudomonas palustris, a metabolically versatile gram-negative purple non-sulfur

296 Here we show that, in the metabolically versatile photoheterotroph Rhodopseudomona

297 miR-211 deficiency rendered melanoma cells metabolically vulnerable by attenuating mitochondrial re

298 irects central carbon metabolism to induce a metabolically vulnerable state susceptible to genetic di

299 cell signaling pathways and rendering cells metabolically vulnerable, making it an extremely attract

300 t and steatosis than WT mice when challenged metabolically with the HF/HC diet; ALR-H-KO mice gained