ライフサイエンスコーパス: metabolite

1 accumulation of fluoxetine and 11 fluoxetine metabolites.

2 traction of the skin surface yields abundant metabolites.

3 bacterial component and inactive disease in metabolites.

4 bout the impact of host genetics on salivary metabolites.

5 rcumvents challenges in processing insoluble metabolites.

6 y for the detection of a different subset of metabolites.

7 tion of TCBZ and additional toxic xenobiotic metabolites.

8 number (n = 2) and yields (0.9-5.1 mol %) of metabolites.

9 ine and SM.C16.1, being the most significant metabolites.

10 vore natural enemies to resist plant defence metabolites.

11 ile highlighted by the upregulation of lipid metabolites.

12 e fine-tuning of delivery of these essential metabolites.

13 causal genes in GWAS data for 46 circulating metabolites.

14 Only 147 out of 1438 metabolites (10%) had an ICC below 0.4 indicating poor s

15 Increased levels of the metabolites 2-hydroxyglutarate, succinate and fumarate o

16 ipids, fatty acids, and low-molecular-weight metabolites, 21 were significantly related to depression

17 exert its antidepressant effects through its metabolite (2R,6R)-hydroxynorketamine ((2R,6R)-HNK)(9).

18 The metabolite 3-MOB along with related branched-chain amino

19 ipids, fatty acids, and low-molecular-weight metabolites; 98 lipid composition and particle concentra

20 Distinct longitudinal patterns of metabolite abundance indicated a greater metabolic varia

21 ways of the heart; however, normalization of metabolite abundance to sample input in heart tissues re

22 steine, and some sulfur-containing secondary metabolites accumulated in higher amounts in ATP sulfury

23 used to explain differential growth rate and metabolite accumulation in A. thaliana and P. trichocarp

24 Assessing correlations between different metabolites across our samples revealed putative functio

25 Many of the metabolite adduct ions were found to contain cluster ion

26 Intestinal microbes and their metabolites affect the development of colorectal cancer

27 roduction and diets, as well as showing that metabolites alone have an acceptable association with th

28 alphaKG-dependent dioxygenases consume the metabolite alphaKG (also known as 2-oxoglutarate) as an

29 n of glutamine in tumours and its downstream metabolite, alphaKG, without increasing biosynthetic int

30 udies of the urinary concentrations of 1,172 metabolites among 1,627 patients with reduced kidney fun

31 Metabolite analyses indicated that these phenotypes were

32 ut the exact mode of action of the serotonin metabolite and the possible interplay between the 2 Trp

33 rom the flora of Java with >16,500 secondary metabolites and 6,255 georeferenced occurrence records t

34 resence of genes for production of secondary metabolites and a considerable number of potential horiz

35 , Krebs cycle intermediates, microbe-derived metabolites and altered metabolite transport.

36 One-year increases in most metabolites and in the weighted score were associated wi

37 We investigated a wide omics panel of metabolites and lipids related to DR in type 1 diabetes.

38 = 566) to identify differentially expressed metabolites and metabolic pathways associated with neuro

39 tivation and cross-reactivity with clozapine metabolites and olanzapine.

40 unch thinning on the accumulation of primary metabolites and on four families of glycosylated aroma p

41 n, distribution, metabolism and excretion of metabolites and pharmaceuticals, as well as biomarkers f

42 s important implications for SIMS imaging of metabolites and pharmaceuticals.

43 and altered metabolism of sulfur-containing metabolites and proteins.

44 for biosynthesis of plant defense secondary metabolites and repressed the accumulation of proteins i

45 lasmodesmata) facilitating rapid exchange of metabolites and signal molecules, plant cells use the ex

46 the (absolute or relative) concentration of metabolites and their isotope incorporation in (13)C-lab

47 mediate the non-specific transport of other metabolites and/or ions.

48 , signaling pathways, and microbiota-related metabolites) and risk of colorectal cancer (CRC).

49 caused by an endogenous and alcohol-derived metabolite, and identify an excision-independent mechani

50 n (1) skeletal muscle concentration of lipid metabolites, and (2) potential changes in the perilipin

51 cumulation of sphingolipids and sphingolipid metabolites, and it has become clear that the intracellu

52 extracellular acidification rate, glycolytic metabolites, and lactate excretion.

53 , the discovery of novel signaling roles for metabolites, and the increasing links between altered me

54 Kynurenine pathway (KP) metabolites are believed to be a link between inflammati

55 Low molecular weight metabolites are essential for defining the molecular phe

56 tly, non-amyloidogenic and amyloidogenic APP metabolites are increased and decreased, respectively.

57 Metabolites are increasingly appreciated for their roles

58 Bacterial specialized metabolites are increasingly recognized as important fac

59 Drugs and drug metabolites are known to interact directly and indirectl

60 l investigation, particularly since catechol metabolites are likely reactive and toxic.

61 PCB 11 and its metabolites are present in human serum, and emerging evi

62 lant biochemistry is challenging because few metabolites are preserved in fossils and because metabol

63 Although different groups of secondary metabolites are synthesized through unique biosynthetic

64 including cholesterol and its precursors and metabolites, are biologically active and important for p

65 oxicity and the role of the agmatine pathway metabolites as biomarkers of oral health.

66 luating effects of diagnosis and severity on metabolites, as moderated by age, sex, and IQ.

67 s Drosophila lifespan, causes alterations of metabolites associated with increased lifespan, and upre

68 DMGV], -18%; P=5.8x10(-18)) and increases in metabolites associated with lipolysis (1-methylnicotinam

69 ably, longitudinal analyses revealed only 10 metabolites associated with progression to T2D, implicat

70 Furthermore, a strong metabolite-based machine-learning classifier was able to

71 e peripheral blood levels of at least one KP metabolite between adults with BD and healthy controls.

72 e Chrome Azurol S assay indicated that these metabolites bind ferric iron, which suppresses their pro

73 5.5 to 88.0%, because the top discriminatory metabolite biomarkers from the optimised protocol remain

74 We apply PRISM 4 to chart secondary metabolite biosynthesis in a collection of over 10,000 b

75 osomal RNA gene sequencing and fecal/urinary metabolites by 1H-NMR spectroscopy was complemented with

76 We measured metabolites by HR-MAS (1)H NMR spectroscopy and DNA cyto

77 insight into the relationship between rumen metabolites, CH(4) production and diets, as well as show

78 Additional metabolite changes including low inositol levels in resp

79 Exercise-induced metabolite changes were variably related to the amount o

80 NIFICANCE STATEMENT The postsynaptic ion and metabolite channel, pannexin-1, is regulated by metabotr

81 zinc, along with its mechanistically related metabolites citrate and aspartate, are widely reported a

82 otypes revealed that chlorination status and metabolite class are strong predictors of the in vitro c

83 circadian rhythm and food intake on several metabolite classes.

84 y examined the relationship between ketamine metabolites, clinical response, psychotomimetic symptoms

85 ior separation capacity to fractionate minor metabolites compared to HPLC.

86 wed simply as structural elucidation of drug metabolites, completed only once compounds entered clini

87 medulla (M) and cortex (C)) showed distinct metabolite compositions.

88 7), despite yielding higher prasugrel active metabolite concentration (ng/mL; 62.3+/-82.6 versus 17.1

89 chewed prasugrel, which led to higher active metabolite concentration but not greater IPA compared wi

90 LK-DFBA allows for calculation of metabolite concentrations and considers metabolite-depen

91 varieties to seek correlations between these metabolite concentrations and the anti-amyloidogenic act

92 NR supplementation does not affect NAD metabolite concentrations in skeletal muscle.

93 dust control on children's urinary phthalate metabolite concentrations.

94 Microbial and plant specialized metabolites constitute an immense chemical diversity, an

95 is predominant in nature, only a handful of metabolites containing (E)-Dhb have been found thus far.

96 e that "Sweating'' has significant effect on metabolites content and composition of S. miltiorrhiza.

97 cted for up to 4 h after injection to assess metabolite-corrected radioactivity in whole blood, plasm

98 -MRS and findings indicate that glia-related metabolites could be valuable in cognitive ageing studie

99 llow us to account for metabolite levels and metabolite-dependent regulation in strain design tools b

100 n of metabolite concentrations and considers metabolite-dependent regulation while still retaining ma

101 beled tracers (such as (15)N-tracers) in any metabolite detectable by LC-MS/MS and in various biologi

102 s demonstrate that this LC-SERS approach has metabolite detection capabilities comparable to the stat

103 ic core and a proliferative outer layer from metabolite distribution.

104 aquaculture products, including the nifursol metabolite (DNSH), was developed.

105 Higher urinary concentrations of phthalate metabolites during early pregnancy were associated with

106 avermectin are mainly produced as secondary metabolites during the stationary phase of growth of Str

107 as the founding member of a novel secondary metabolite family.

108 ify the dicarbonyl methylglyoxal as a marker metabolite for MDSCs that mediates T cell paralysis and

109 GlcNAc is a rate-limiting metabolite for N-glycan branching.

110 availability of luminal succinate, a crucial metabolite for the growth of C. difficile, and therefore

111 trate that while deuteration can reduce P450 metabolite formation, impacts on phase II metabolism and

112 hromatography (HPCCC) to study the secondary metabolite formation, whereby HPCCC showed a superior se

113 The most discriminating metabolite found is isocaproyltaurine, a covalent conjug

114 at plants use to generate complex, bioactive metabolites from simple amino acids.

115 show that the effect estimates of statins on metabolites from the cross-sectional study are comparabl

116 an scattering (SERS) for online detection of metabolites from tumor lysates following liquid chromato

117 The release rate of (177)Lu (or labeled metabolites) from tumor cells had the strongest effect o

118 The fungal metabolite galiellalactone (1) was, as its acetate 4, di

119 the levels of octadecanedioate and vitamin E metabolites (gamma-CEHC and gamma-CEHC glucuronide); MR

120 mes (598 per species) and prolific secondary metabolite gene clusters (73 per species) in section Fla

121 mitate, in turn synthesized from a precursor metabolite generated in the isoleucine catabolic pathway

122 lism as well as by the realization that this metabolite has key roles in cells beyond the muscle and

123 Nitrogen- and carbon-containing metabolites have been shown to activate TORC1 in yeast,

124 enicity among species of zearalenone and its metabolites have been structurally explained.

125 few decades, sphingolipids and sphingolipid metabolites have gained attention because of their essen

126 More importantly, 29% extracted microbial metabolites have not been captured by existing databases

127 ypic assays, and identification of secondary metabolites, highlights the genetic and metabolic divers

128 osis, cell adhesion, signal transduction, or metabolite homeostasis.

129 xpression and levels of additional genes and metabolites, however, were altered in Sin3A+Sam-S dual k

130 Changes included reductions in metabolites implicated in insulin resistance (glutamate,

131 L-lactate is an abundant metabolite in a number of niches in host organisms and r

132 ns of the taxa maintained on each individual metabolite in the mixture, weighted for the growth each

133 We found higher levels of glia-related metabolites in all brain regions in older individuals.

134 tomatic identification and quantification of metabolites in approximately thirty seconds per spectrum

135 an overall alteration in gut microbiome and metabolites in association with SE infection.

136 smic binding proteins such as RBP to measure metabolites in different biological fluids, tissues, and

137 t genes to regulate the yield of specialized metabolites in hemp.

138 ation, potentially altering the abundance of metabolites in individual cells.

139 ography-mass spectrometry and identified 134 metabolites in maternal fasting plasma at 26-28 weeks of

140 -MS/MS method for confirmation of nitrofuran metabolites in meat and aquaculture products, including

141 s for the analysis of tryptophan degradation metabolites in mouse serum.

142 ved alternative for quantitation of ASOs and metabolites in plasma and tissue samples, showing a grea

143 ility of the pyrimidine (uracil) degradation metabolites in predicting 5-fluorouracil toxicity and th

144 severity included reduced levels of multiple metabolites in white matter and the perisylvian cortex a

145 PPP metabolites, in turn, reinforce AKT activation and furth

146 ictive power, and each explained hundreds of metabolites-in some cases, explaining more than 50% of t

147 The CHD associations of a subset of 4 metabolites including C58:11 triacylglycerol, C54:9 tria

148 lated high concentrations of upstream lysine metabolites including Delta1-piperideine-6-carboxylic ac

149 rst time in addition to well-known secondary metabolites including emodin, aloe-emodin, beta-sitoster

150 cancer cells altered the abundance of redox metabolites, including an increase in glutathione.

151 ored this functional diversity for secondary metabolites, including signaling robustness and cost-eff

152 tricarboxylic acid (TCA) cycle function and metabolite induction.

153 This metabolite inhibits the action of a group of exorribonuc

154 However, unlike certain lipid metabolites, intramuscular triglyceride (IMTG) stored wi

155 Whereas direct toxicity exerted by APAP metabolites is a key determinant for early hepatocytes i

156 er refining the process of managing reactive metabolite issues in drug development.

157 4,15-epoxyeicosatrienoic acid (14,15-EET), a metabolite known to influence cellular proliferation, mi

158 are characterized by the production of toxic metabolites known as cyanotoxins.

159 ssists in reducing the accumulation of lipid metabolites known to contribute to skeletal muscle insul

160 ntent while minimising accumulation of lipid metabolites known to disrupt skeletal muscle insulin sig

161 wn to be involved in the regulation of blood metabolites, leading to significant insights into the pa

162 Baseline metabolite levels (except for glutathione) were higher i

163 ts assumptions could allow us to account for metabolite levels and metabolite-dependent regulation in

164 resulted in distinct shifts in steady-state metabolite levels and significant changes in glutathione

165 revealed decreases in acetaminophen-sulfate metabolite levels in both the amoxicillin and ampicillin

166 roach gave accurate predictions of the major metabolite levels throughout fruit development, as well

167 In contrast, metabolite levels were lower in parasite tissues compare

168 sed levels of the glucose-derived dicarbonyl metabolites like methylglyoxal (MGO), glyoxal (GO), and

169 Global transcriptome analysis and cell wall metabolite measurement implicate cell wall metabolism/in

170 resonance metabolomics platform provided 230 metabolite measures: 51 lipids, fatty acids, and low-mol

171 onfirming an important enterohepatic axis of metabolite-microbiome interaction resulting in maintenan

172 In this essay, we suggest the ways these metabolites might affect microbial communities and ultim

173 amples underscore the opinion that microbial metabolite mimicry of promiscuous ligand-receptor intera

174 Furthermore, a summary of metabolites modestly associated with gastrointestinal dy

175 evaluated by trapping acetaminophen reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI) with hum

176 lter nitrate supply affect levels of hypoxic metabolites, nectar volume and nectar sugar composition.

177 reduced intracellular concentrations of key metabolites needed for cell division.

178 Sphingosine, a metabolite of ceramide with antimicrobial properties, is

179 Bilirubin is a yellow-colored metabolite of heme degradation (a bile pigment), once be

180 reased concentrations of kynurenine, a major metabolite of tryptophan that plays a role in neuroinfla

181 var. chinense (SHC)) on the distribution and metabolites of As in broiler breasts.

182 guration towards the synthesis of protective metabolites of those fruits can possibly confer enhanced

183 e k-shortest metabolic paths between any two metabolites or reactions to identify the main metabolic

184 e used to accelerate the clearance of drugs, metabolites, or toxins and reverse the decreased express

185 metabolomics approach revealed that putative metabolites other than flavonoids may significantly cont

186 gases, Hct and [Hb], blood viscosity, and NO metabolites (ozone-based chemiluminescence) were measure

187 NAD(+) is an essential metabolite participating in cellular biochemical process

188 Likewise, standard FRA provided 21/30 metabolites passing the t-test, with 5/21 undiscovered b

189 D for these and other specific gut microbial metabolites/pathways has been shown through numerous mec

190 let COX-1 activity, and urinary prostacyclin metabolite (PGIM) excretion were measured at randomizati

191 The variation in several metabolite pools such as malate, fumarate or citrate, an

192 This metabolite potentiates interleukin-1beta production, res

193 Campylobacter jejuni monitors intestinal metabolites produced by the host and microbiota to initi

194 fy and access attractive groups of secondary metabolite producers.

195 m, their rational engineering for commercial metabolite production in photoautotrophic, cyanobacteria

196 l herb, we reveal novel associations between metabolite profile and sensory quality, by integrating n

197 e continued to obtain the most comprehensive metabolite profile of HBV.

198 mple-handling protocols can affect the blood metabolite profile, it is vital to understand which fact

199 hese results demonstrate that complex PCB 11 metabolite profiles are formed in HepG2 cells that warra

200 r magnetic resonance-derived lipoprotein and metabolite profiles in the ANGES cohort with a goal to i

201 Urinary metabolite profiles revealed decreases in acetaminophen-

202 In this study, we performed metabolite profiling in both brain (n = 109) and matchin

203 oach, the influence on primary and secondary metabolite profiling in skin + pulp/flesh and seeds were

204 hysiological parameters, gene expression and metabolite profiling on plants grown under glasshouse or

205 Select microbiota-dependent metabolites promoted axon outgrowth from fetal thalamic

206 y for fast, enzyme-multiplexed screening for metabolite-protein adducts was developed.

207 r signal-to-noise ratio by 31%, more precise metabolite quantification by 22%, and an increase by 21%

208 cation, while FNP caused a decrease of total metabolite quantities in mycelia.

209 However, higher metabolite quantities were found in media following FNP

210 fetal concentrations of parent compounds and metabolites quite accurately (within a factor of five).

211 More specifically, we address how the OCM metabolites regulate the fidelity and rate of translatio

212 disrupted in the symbiosis were elevated in metabolites related to plant defense.

213 ed when employing deuteration to reduce P450 metabolite-related hepatotoxicity.

214 with increased concentrations of a range of metabolites relating to glycolysis (lactate, pyruvate, s

215 uent, and spent GAC attributes neonicotinoid/metabolite removal to GAC under real-world conditions fo

216 ult in proinflammatory and anti-inflammatory metabolites, respectively.

217 The detection of atabecestat metabolite-responsive T-cell clones activated via a phar

218 IPM, including trafficking of nutrients and metabolites, retinal attachment, and interactions needed

219 All 4 metabolites returned to control levels by day 90.

220 ene expression and the contents of flavonoid metabolites revealed potential critical genes involved i

221 Here, we performed global metabolite screening with metabolite set enrichment coup

222 pathway enrichment analysis was performed on metabolites selected by the above methods.

223 e performed global metabolite screening with metabolite set enrichment coupled with transcriptome and

224 Due to the complexity of TCM, changes in metabolites should be investigated metabolome-wide after

225 itives among top: manual curation of top 100 metabolites showed a true precision of 0.55, representin

226 genes can inform predictions of specialized metabolite structure and function.

227 AH degradation network data and intermediate metabolite structures, gaining information about the che

228 in just 16 min), while changes in different metabolites suggest a complex multipathway response that

229 Results for individual BCAA metabolites suggested a modest association for leucine w

230 In addition, isotopic peaks from an enriched metabolite tend to have low abundances, which makes liqu

231 EOs are complex mixture of secondary metabolites (terpenes, phenolic compounds, alcohol).

232 The T4 metabolite TETRAC was the most active TH on PPARgamma wi

233 or delta-T3-13'COOH), is a natural vitamin E metabolite that has preliminarily been identified as a m

234 obutyric acid (BABA) is an endogenous stress metabolite that induces broad-spectrum disease resistanc

235 There was no overlap with metabolites that associated with HFE or SERPINA1 variant

236 ion in ASD is provided, and a pilot study of metabolites that can be transferred via fecal microbial

237 zymes were used to make potentially reactive metabolites that can react with test protein in the well

238 A decision tree algorithm identified 3 metabolites that correctly identified TB status at disti

239 ium, and white blood cell count, to identify metabolites that differed between patients who did vs di

240 proach, we have directly identified specific metabolites that exert transcriptional, translational, a

241 esults helped to prioritize potential active metabolites that modulated the hypothermic response to C

242 the identified azo dye excipients, producing metabolites that no longer inhibit OATP2B1 transport.

243 We find that pyruvate and DHAP were the metabolites that responded most strongly to increasing f

244 Based on our approach, we observed 107 metabolites that show different distributions and intens

245 Metabolites that signficantly increased were assayed for

246 We identified 60 metabolites that were associated significantly with AMD,

247 wed calculation of kinetic features of these metabolites, thus enabling a detailed analysis of the va

248 s across all tested modeling approaches when metabolite time course data were missing, but found thes

249 response in E. coli and links its associated metabolites to a major immunological marker of IBD.

250 To better understand the potential for metabolites to influence posttranslational modifications

251 nting molecule MR1 presents riboflavin-based metabolites to Mucosal-Associated Invariant T (MAIT) cel

252 through signalling by microbially modulated metabolites to neurons in the developing brain.

253 G storage and minimise accumulation of lipid metabolites to protect skeletal muscle insulin signallin

254 bioactivities described for these secondary metabolites, to offer an overview of the situation to co

255 f interest, as well as simulated ToxCast(TM) metabolites, totaling 55,450 chemical structures.

256 ented alcohol-induced increase in harmful AR metabolites, toxic aldehydes, steatosis, ER stress, apop

257 tes, microbe-derived metabolites and altered metabolite transport.

258 lyzes the synthesis of the sucrose-signaling metabolite trehalose 6-phosphate (Tre6P) and is essentia

259 resulted in the accumulation of hydroxylated metabolites upon exposure to PCB-153, leading to oxidati

260 nteractions also ensure the constant flow of metabolites used by the microbiome to alter reproduction

261 ed urinary concentrations of eight phthalate metabolites using mass spectrometry, and biomarkers of t

262 Metabolites varied between sampling areas, some were bro

263 as well as structurally diverse specialized metabolites via multistep metabolic pathways.

264 ditional difficulties surrounding low weight metabolite visualization include high resolution imaging

265 When we profiled microbiota and metabolites, we observed significant alterations.

266 performed on feces, whereas urine and fecal metabolites were analyzed by gas chromatography and liqu

267 Also, 57 of 60 metabolites were associated significantly with complemen

268 showed that genetically high levels of these metabolites were associated with lower odds of CHD.

269 Majority of the metabolites were detected in higher quantity in mycelia

270 n algorithms applied to group lasso-selected metabolites were evaluated for classifying case status.

271 31 and 49 identified metabolites were exclusively detected in SSM and NSSM, r

272 DNA, miRNA, and metabolites were extracted from stool samples of 15 CD p

273 Microbiome-associated histidine and tyrosine metabolites were increased in both sexes, while 1,5-anhy

274 st severity; 9alpha,11beta-PGF(2) and PGI(2) metabolites were measured for control purposes.

275 Estrogen metabolites were measured in blood and urine samples.

276 activity and tricarboxylic acid (TCA) cycle metabolites were measured in cells collected from the pr

277 Plasma metabolites were measured using liquid chromatography-ta

278 Eight metabolites were positively associated with the risk all

279 ary concentrations of BPA, PA, and phthalate metabolites were positively associated with urinary KIM-

280 control individuals, but most discriminatory metabolites were related to diet or medications.

281 dietary and endogenously produced vitamin D metabolites were under polygenic control in African calv

282 uits exhibiting lower levels of fermentative metabolites when compared to fruits kept in an ambient a

283 fluid influx to control absorption of fungal metabolites, which can be toxic to epithelial cells and

284 YP) enzymes and includes PCB oxidation to OH-metabolites, which often display a higher toxicity than

285 w traces of glyphosate, glufosinate or their metabolites, while in 10.5% of the samples a quantifiabl

286 lymphocytes and macrophages release specific metabolites, while retaining their membrane integrity.

287 Monoterpenes are non-polar secondary metabolites widely used by industry due to their excelle

288 ase 1 (IRG1), which synthesizes itaconate, a metabolite with antimicrobial activity.

289 erpolarize a broad range of substrates (e.g. metabolites with carboxyl groups) for various applicatio

290 The metabolites with differential abundance included those f

291 microbial genes that synthesize specialized metabolites with diverse functions, including siderophor

292 Herein, we describe bacterial metabolites with known or suspected neuromodulatory acti

293 fingerprinting and revealed the presence of metabolites with significant influence on the self-incom

294 tigate the causal association of the 25(OH)D metabolites with T2D (including 80,983 T2D cases and 842

295 usal association of total 25(OH)D or 25(OH)D metabolites with T2D and argue against the use of vitami

296 olomics aims to quantify the complete set of metabolites within a biological system, most commonly by

297 an spectro-microscopy for spatial mapping of metabolites within single cells, with the specific goal

298 roposed, based on molecular docking of plant metabolites within the ATP and D-cycloserine binding poc

299 in line with the contrasting roles for these metabolites within the CAM mesophyll and stomatal comple

300 e (TMAO), an intestinal microbiome-dependent metabolite, worsens graft-versus-host disease (GVHD).