ライフサイエンスコーパス: metabotropic

1 ization of compound 19f binding to the human metabotropic 2 glutamate (hmGlu2) site was established b

2 er, we demonstrate that these ionotropic and metabotropic 5-HT receptors have a synergistic effect th

3 it is known that serotonin release activates metabotropic 5-HT1A autoreceptors located on serotonin n

4 sion in the dorsal raphe nucleus mediated by metabotropic 5-HT1A autoreceptors may occur via point-to

5 We identify that both ionotropic and metabotropic 5-hydroxytryptamine (5-HT) receptors are ex

6 We therefore investigated metabotropic acetylcholine receptor-mediated modulation

7 This pathway requires the metabotropic action of kainate receptors and activation

8 onse, particularly with regard to targets on metabotropic and ionotropic receptors.

9 ated channel function, suggesting GLR-3 as a metabotropic cold receptor.

10 We conclude that metabotropic effects of NAS on GABAergic inhibition are

11 is mediated via postsynaptic ionotropic and metabotropic GABA and metabotropic glutamate receptors.

12 Stimulation of the metabotropic GABA(B) receptor by gamma-aminobutyric acid

13 on the activation of ionotropic GABA(A)-R or metabotropic GABA(B)-R.

14 by ionotropic GABAA receptors (GABAARs) and metabotropic GABAB receptors (GABABRs).

15 Mechanisms controlling the metabotropic gamma-aminobutyric acid receptor (GABAB) ce

16 Metabotropic gamma-aminobutyric acid receptors (GABA(B))

17 The metabotropic glutamate (Glu) receptors (mGluRs) play key

18 The group II metabotropic glutamate (mGlu II) receptors exert a well

19 the Galpha(q/11)-coupled mGlu(1) subtype of metabotropic glutamate (mGlu) receptor.

20 studies suggest that antagonists of group II metabotropic glutamate (mGlu) receptors (mGlu(2) and mGl

21 studies suggest that antagonists of group II metabotropic glutamate (mGlu) receptors (mGlu2 and mGlu3

22 The metabotropic glutamate (mGlu) receptors are a family of

23 The metabotropic glutamate (mGlu) receptors are a group of e

24 blished that selective activation of group I metabotropic glutamate (mGlu) receptors induces LTD of s

25 eveal that coincident activation of group II metabotropic glutamate (mGlu) receptors with betaARs in

26 Type 5 metabotropic glutamate (mGlu5) receptors might be partic

27 Metabotropic glutamate 1 (mGlu) receptor has been propos

28 racted withdrawal, characterized by elevated metabotropic glutamate 1/5 receptor function and Homer2

29 ng efforts to identify novel ligands for the metabotropic glutamate 2 and 3 (mGlu2/3) receptors, we h

30 Positive allosteric modulators of the metabotropic glutamate 2 receptor have generated great i

31 n rodent models pointed toward activation of metabotropic glutamate 2/3 (mGlu2/3) receptors as a new

32 d near-infrared lasers to reversibly silence metabotropic glutamate 5 (mGlu(5)) receptor activity in

33 Negative allosteric modulation of the metabotropic glutamate 5 (mGlu(5)) receptor has emerged

34 The metabotropic glutamate 5 (mGlu(5)) receptor is important

35 nds to quantify regional dopamine D(2/3) and metabotropic glutamate 5 (mGlu5) receptor availability,

36 The metabotropic glutamate 5 (mGlu5) receptor has shown prom

37 The metabotropic glutamate 5 receptor and the cannabinoid ty

38 itical for novelty detection, and perirhinal metabotropic glutamate 5 receptors (mGlu5) are downregul

39 Metabotropic glutamate 5 receptors, present at the posts

40 to the class C family that also includes the metabotropic glutamate and gamma-aminobutyric acid recep

41 Activation of orexin, neurotensin, and metabotropic glutamate Gq/11-linked receptors mimicked t

42 us studies showing that FMRP couples Group I metabotropic glutamate receptor (GpI mGluR) signaling to

43 Group II metabotropic glutamate receptor (mGlu(2/3)) antagonists

44 Metabotropic glutamate receptor (mGluR) 5 exhibits promi

45 release, and its distribution overlaps with metabotropic glutamate receptor (mGluR) 5 in regional br

46 facilitate the encoding of new memories via metabotropic glutamate receptor (mGluR) activation.

47 e impairments were rescued by treatment with metabotropic glutamate receptor (mGluR) antagonists or l

48 orders have been connected to alterations in metabotropic glutamate receptor (mGluR) signalling.

49 s altered at steady state and in response to metabotropic glutamate receptor (mGluR) stimulation, but

50 whether activation of one particular GPCR, a metabotropic glutamate receptor (mGluR), can reduce cone

51 tein-coupled receptors, specifically via the metabotropic glutamate receptor (mGluR).

52 Type 1 metabotropic glutamate receptor (mGluR1)-dependent signa

53 The group 2 metabotropic glutamate receptor (mGluR2/3) agonist, poma

54 ith movement execution, EAAC1 limits group I metabotropic glutamate receptor (mGluRI) activation, fac

55 elanoma due to ectopic overexpression of the metabotropic glutamate receptor 1 (Grm1) in melanocytes.

56 Previously, we have illustrated the role of metabotropic glutamate receptor 1 (GRM1) in neoplastic t

57 G protein-coupled receptor (GPCR) family C, metabotropic glutamate receptor 1 (mGluR1) and mGluR5.

58 Metabotropic glutamate receptor 1 (mGluR1) function in P

59 an excellent PET radioligand for quantifying metabotropic glutamate receptor 1 (mGluR1) in monkey bra

60 The metabotropic glutamate receptor 1 (mGluR1) is abundantly

61 well as the emergence of glutamate-activated metabotropic glutamate receptor 1 (mGluR1) signaling, ar

62 Through metabotropic glutamate receptor 1 (mGluR1)-mediated syna

63 utamate to the ionotropic AMPA receptors and metabotropic glutamate receptor 1 and members of group 2

64 hese results highlight the important role of metabotropic glutamate receptor 1 in modulating sleep du

65 nd two different mutations in the same gene (metabotropic glutamate receptor 1) from two independent

66 iated protein 29, glutamate decarboxylase 1, metabotropic glutamate receptor 1, and excitatory amino

67 There were female-specific changes in metabotropic glutamate receptor 1, NMDA receptor 2A, alp

68 nctional evidence that ERbeta interacts with metabotropic glutamate receptor 1a (mGluR1a) signaling t

69 estrogen receptor beta interacting with the metabotropic glutamate receptor 1a.

70 t the presynaptic G protein-coupled receptor metabotropic glutamate receptor 2 (mGlu(2)) robustly inh

71 Positive allosteric modulators (PAM) of metabotropic glutamate receptor 2 (mGluR2) are a potenti

72 Here, we find that metabotropic glutamate receptor 2 (mGluR2) signaling, wh

73 the localization and trafficking of class C metabotropic glutamate receptor 2 (mGluR2) through a mec

74 ry, biology, and light to control endogenous metabotropic glutamate receptor 2 (mGluR2), a Family C G

75 gical interactions between 5-HT(2A)R and the metabotropic glutamate receptor 2 (mGluR2).

76 vation process observed biophysically on the metabotropic glutamate receptor 2 homodimer.

77 blot analysis shows increased expression of metabotropic glutamate receptor 2 in THL synaptosomes of

78 We also determined the effect of the novel metabotropic glutamate receptor 2 positive allosteric mo

79 ggest that positive allosteric modulators of metabotropic glutamate receptor 2 should be considered f

80 Two metabotropic glutamate receptor 2/3 (mGluR2/3) agonists

81 ies have revealed that genetic variations in metabotropic glutamate receptor 3 (mGlu3) affect perform

82 Altering the metabotropic glutamate receptor 3 (mGluR3) by pharmacolo

83 The metabotropic glutamate receptor 4 (mGluR4) is an emergin

84 Negative allosteric modulators (NAMs) of the metabotropic glutamate receptor 5 (mGlu(5)) hold great p

85 regulator of synaptic protein synthesis, the metabotropic glutamate receptor 5 (mGlu5) protein, is si

86 hol drinking increases signaling through the metabotropic glutamate receptor 5 (mGlu5) receptor withi

87 entified a novel role of GluD1 in regulating metabotropic glutamate receptor 5 (mGlu5) signaling in t

88 genic procedures to investigate the role for metabotropic glutamate receptor 5 (mGlu5) signaling with

89 e allosteric modulators (NAMs) targeting the metabotropic glutamate receptor 5 (mGlu5) subtype are cu

90 Metabotropic glutamate receptor 5 (mGlu5)-positive allos

91 ntify regional dopamine D(2/3) receptors and metabotropic glutamate receptor 5 (mGluR5) and assessed

92 lnesses, including disorders associated with metabotropic glutamate receptor 5 (mGluR5) and dopaminer

93 ly (within 30 min) and require activation of metabotropic glutamate receptor 5 (mGluR5) and protein s

94 sts with or without prior treatment with the metabotropic glutamate receptor 5 (mGluR5) antagonist 2-

95 Here we advance the novel concept that metabotropic glutamate receptor 5 (mGluR5) fails to enga

96 PrP(C), laminin, and metabotropic glutamate receptor 5 (mGluR5) form a protei

97 Negative allosteric modulators (NAM) of metabotropic glutamate receptor 5 (mGluR5) have been imp

98 Drugs targeting metabotropic glutamate receptor 5 (mGluR5) have therapeu

99 Deleting metabotropic glutamate receptor 5 (mGluR5) in mice pertu

100 We found that the metabotropic glutamate receptor 5 (mGluR5) in the periaq

101 For example, the metabotropic glutamate receptor 5 (mGluR5) is concentrat

102 Astrocyte expression of metabotropic glutamate receptor 5 (mGluR5) is consistent

103 While abnormal signaling mediated through metabotropic glutamate receptor 5 (mGluR5) is involved i

104 over of synaptic glutamate, which stimulates metabotropic glutamate receptor 5 (mGluR5) on a small po

105 cally, neurons release glutamate to activate metabotropic glutamate receptor 5 (mGluR5) on astrocytes

106 clinical data suggest that inhibition of the metabotropic glutamate receptor 5 (mGluR5) receptor migh

107 Specifically, the metabotropic glutamate receptor 5 (mGluR5) represents a

108 ligation induces a re-emergence of immature metabotropic glutamate receptor 5 (mGluR5) signaling in

109 esses developmental expression of astroglial metabotropic glutamate receptor 5 (mGluR5), a major rece

110 mouse model of Rett syndrome (Mecp2 KO) that metabotropic glutamate receptor 5 (mGluR5)- and protein-

111 esult from glutamate spillover, initiating a metabotropic glutamate receptor 5 (mGluR5)-dependent inc

112 h the same genetic deficiency, we found that metabotropic glutamate receptor 5 (mGluR5)-dependent syn

113 ivity of NMDA receptors (NMDARs) and group I metabotropic glutamate receptor 5 (mGluR5).

114 posed of cellular prion protein (PrP(C)) and metabotropic glutamate receptor 5 (mGluR5).

115 exaggerated protein synthesis downstream of metabotropic glutamate receptor 5 (mGluR5).

116 lutamatergic system, in particular, cerebral metabotropic glutamate receptor 5 (mGluR5).

117 is to reveal the cell-autonomous role of the metabotropic glutamate receptor 5 (mGluR5).

118 brain-derived neurotrophic factor (BDNF) and metabotropic glutamate receptor 5 (mGluR5).

119 use model that has reduced Homer1 binding to metabotropic glutamate receptor 5 (mGluR5).

120 apparently equivalent PKC regulatory site in metabotropic glutamate receptor 5 (Ser-839) aligns not w

121 e receptors) or nonhyperbolic relationships (metabotropic glutamate receptor 5 and calcium-sensing re

122 Thus, the interaction between metabotropic glutamate receptor 5 and cellular prion pro

123 FMRP in adult-born neurons and rescued by an metabotropic glutamate receptor 5 antagonist.

124 droxy-5-methyl-4-isoxazolepropionic acid and metabotropic glutamate receptor 5 receptors.

125 r prion protein associates via transmembrane metabotropic glutamate receptor 5 with the intracellular

126 induced in GABA cells that was dependent on metabotropic glutamate receptor 5, and cannabinoid recep

127 ceptors, NMDA receptors, P2Y1 ATP receptors, metabotropic glutamate receptor 5, and TRP channels did

128 GluR1, GABABR1, and GABABR2 levels, whereas metabotropic glutamate receptor 5, NMDA receptor 2B, Glu

129 on domain containing protein 12, mitofusin2, metabotropic glutamate receptor 5, p21-activated kinase

130 gamma-aminobutyric acidergic dysfunction and metabotropic glutamate receptor 5-associated long-term d

131 blockade of either cellular prion protein or metabotropic glutamate receptor 5.

132 bipolar cell glutamatergic transmission, the metabotropic glutamate receptor 6 and voltage-dependent

133 a new, orally bioavailable and CNS-penetrant metabotropic glutamate receptor 7 (mGlu(7)) negative all

134 two separate presynaptic components: mGluR7 (metabotropic glutamate receptor 7) and GluK2-KARs (kaina

135 -intrinsic manner, with postsynaptic Group 1 metabotropic glutamate receptor activation triggering lo

136 uts but did not require postsynaptic Group 1 metabotropic glutamate receptor activation.

137 Our experiments show metabotropic glutamate receptor and endocannabinoid 2-ar

138 d by systemic administration of the group II metabotropic glutamate receptor antagonist LY341495.

139 om a therapeutic standpoint because numerous metabotropic glutamate receptor antagonists are availabl

140 annel gene Kcna1 and decreased expression of metabotropic glutamate receptor gene Grm5.

141 tingly, eCB-LTD in PE animals was rescued by metabotropic glutamate receptor I activation, suggesting

142 tudy demonstrates that expression of GRM3, a metabotropic glutamate receptor mainly expressed in mamm

143 e AMPA-type glutamate receptor GLR-1 and the metabotropic glutamate receptor MGL-1 in one of the prim

144 ippocampal subfields, we speculated that the metabotropic glutamate receptor mGlu5 may regulate infor

145 show that agonist activation of the group I metabotropic glutamate receptor mGluR1 increases the str

146 t of ethanol-induced excitation required the metabotropic glutamate receptor mGluR1.

147 Glutamate directs GAD67 expression via the metabotropic glutamate receptor mGluR1beta on GABApre te

148 Stimulation of the postsynaptic metabotropic glutamate receptor mGluR5 triggers retrogra

149 Upon binding glutamate, the metabotropic glutamate receptor mGluR6 activates the het

150 ment, we detect excess "gain of function" of metabotropic glutamate receptor signaling at an importan

151 hypothesized that the activation of group I metabotropic glutamate receptor signaling though the fra

152 e with high pharmacological specificity that metabotropic glutamate receptor signaling triggers openi

153 lso highlight emerging evidence that altered metabotropic glutamate receptor signalling and disrupted

154 hine and cocaine exposure, we identified the metabotropic glutamate receptor subtype 4 (mGluR4) as a

155 We discovered that expression of metabotropic glutamate receptor subtype 5 (mGluR5) in th

156 ld be less disruptive have been proposed and metabotropic glutamate receptor subtype 5 (mGluR5) repre

157 al framework for the activation mechanism of metabotropic glutamate receptor subtype 5.

158 dvance the novel concept that a breakdown of metabotropic glutamate receptor subtype mGluR5 and endoc

159 s in the discovery of allosteric ligands for metabotropic glutamate receptor subtypes 1-5 and 7 (mGlu

160 Non-selective antagonists of metabotropic glutamate receptor subtypes 2 (mGlu(2)) and

161 We assessed the role of group II metabotropic glutamate receptor subtypes 2 (mGlu(2)) and

162 nchronous stimulation of a dimeric GPCR, the metabotropic glutamate receptor type 1 (mGluR1), by two

163 Moreover, contextual fear learning induced a metabotropic glutamate receptor type 1 (mGluR1)-mediated

164 r-crossing bispecific antibody antagonist of metabotropic glutamate receptor type 1.

165 ng domains with the ligand-binding domain of metabotropic glutamate receptor type 2 (mGluR2).

166 recently showed marked global reductions in metabotropic glutamate receptor type 5 (mGluR5) binding

167 in striatal astrocytes through activation of metabotropic glutamate receptor type 5 (mGluR5) signalin

168 ow abnormalities in tissue concentrations of metabotropic glutamate receptor type 5 (mGluR5).

169 egrating neurons through a G protein-coupled metabotropic glutamate receptor, MGL-1, to release local

170 anol excitation requires the activity of the metabotropic glutamate receptor, mGluR1, which is known

171 s, synaptic transmission is initiated by the metabotropic glutamate receptor, mGluR6, that signals vi

172 finity, selective antibody antagonist of the metabotropic glutamate receptor-1 (BBB-mGluR1), a widely

173 roteins: ankyrin-R, cell adhesion molecules, metabotropic glutamate receptor-1 (mGluR1), voltage-gate

174 t is induced postsynaptically and depends on metabotropic glutamate receptor-5 activation.

175 absence of FMRP in neurons abolishes group 1 metabotropic glutamate receptor-dependent DGK activity c

176 and behavioral measures to demonstrate that metabotropic glutamate receptor-induced sensitization of

177 Accordingly, metabotropic glutamate receptor-mediated long-term depre

178 ough the system Xc- antiporter to activate a metabotropic glutamate receptor.

179 nucleus accumbens core (NAcore) to stimulate metabotropic glutamate receptor5 (mGluR5) on neuronal ni

180 Pharmacological manipulations of Group 1 metabotropic glutamate receptors (G1 mGluRs) demonstrate

181 "MAG" PTLs for ionotropic and metabotropic glutamate receptors (GluRs) are based on an

182 ssive mRNA translation downstream of group I metabotropic glutamate receptors (mGlu1/5) is a core pat

183 Group I metabotropic glutamate receptors (mGluR) are a target of

184 ssion (LTD) elicited by activation of type-I metabotropic glutamate receptors (mGluR-LTD).

185 linear Ca(2+) signals are mediated by type-1 metabotropic glutamate receptors (mGluR1s) when the CF i

186 Group II metabotropic glutamate receptors (mGluR2 and mGluR3) may

187 Group II metabotropic glutamate receptors (mGluR2/3), which coupl

188 Here, we examine the significance of type 5 metabotropic glutamate receptors (mGluR5s) for behaviora

189 indings show that EAAC1 limits activation of metabotropic glutamate receptors (mGluRIs) in the striat

190 Activation of Group I metabotropic glutamate receptors (mGluRs) activates sign

191 quires co-activation of postsynaptic group I metabotropic glutamate receptors (mGluRs) and Ca(2+) -pe

192 we focus on the class C GPCRs, which include metabotropic glutamate receptors (mGluRs) and gamma-amin

193 In principle, metabotropic glutamate receptors (mGluRs) are also suita

194 Metabotropic glutamate receptors (mGluRs) are class C, s

195 Metabotropic glutamate receptors (mGluRs) are dimeric G-

196 Metabotropic glutamate receptors (mGluRs) are mainly kno

197 Metabotropic glutamate receptors (mGluRs) are mandatory

198 Metabotropic glutamate receptors (mGluRs) are, in princi

199 evoked responses, we show that activation of metabotropic glutamate receptors (mGluRs) by general and

200 ation of these two distinct release modes by metabotropic glutamate receptors (mGluRs) constitutes cr

201 brain and a selective binding with group III metabotropic glutamate receptors (mGluRs) in trans.

202 gonists of ionotropic glutamate receptors or metabotropic glutamate receptors (mGluRs) or orthosteric

203 Group I metabotropic glutamate receptors (mGluRs) play important

204 Group I metabotropic glutamate receptors (mGluRs) play important

205 Stimulation of synaptic metabotropic glutamate receptors (mGluRs) reactivates tr

206 st synapse in the visual system, presynaptic metabotropic glutamate receptors (mGluRs) regulate cone

207 Activating Group 1 (Gp1) metabotropic glutamate receptors (mGluRs), including mGl

208 Of the eight metabotropic glutamate receptors (mGluRs), mGluR5 is the

209 single-molecule subunit counting on class C metabotropic glutamate receptors (mGluRs), we map dimeri

210 otein tags to create a family of light-gated metabotropic glutamate receptors (mGluRs).

211 plasticity induced at excitatory synapses by metabotropic glutamate receptors (mGluRs).

212 branched photoswitchable compounds to target metabotropic glutamate receptors (mGluRs).

213 e allosteric modulators selective for either metabotropic glutamate receptors 2 (mGlu(2)) or 3 (mGlu(

214 The presynaptic inhibitory metabotropic glutamate receptors 2 and 3 (mGluR2/3) are

215 Vasoconstriction required metabotropic glutamate receptors and CYP omega-hydroxyla

216 vation of both g-protein coupled GABA(B) and metabotropic glutamate receptors and involved an increas

217 Metabotropic glutamate receptors are family C G-protein-

218 sent study showed that activation of group I metabotropic glutamate receptors enhanced spontaneous gl

219 ries that control the trafficking of group I metabotropic glutamate receptors in the central nervous

220 Activation of the FMRP pathway by group I metabotropic glutamate receptors is involved in regulati

221 ct to the resting membrane potential, type-1 metabotropic glutamate receptors locally enhance Ca(2+)

222 At the same time, metabotropic glutamate receptors mediate 20-hydroxyeicos

223 arly gene Homer1a and signaling from group I metabotropic glutamate receptors mGluR1/5.

224 inal ON and OFF bipolar cells, and the novel metabotropic glutamate receptors of ON bipolar-cell dend

225 We here demonstrate that metabotropic glutamate receptors of subtype 5 (mGluR5) c

226 the tonic activation of presynaptic group II metabotropic glutamate receptors on inhibitory nerve ter

227 glutamate receptor 1 and members of group 2 metabotropic glutamate receptors on the plasma membrane.

228 h-power state because blocking ionotropic or metabotropic glutamate receptors results in high-power L

229 c to connections with VLEs, requires group I metabotropic glutamate receptors, and has a presynaptic

230 ntagonists targeting multiple ionotropic and metabotropic glutamate receptors, and intracellular casc

231 l elements, AD-related genes, ionotropic and metabotropic glutamate receptors, cholinergic enzymes an

232 umption in a manner requiring intact group 1 metabotropic glutamate receptors, Homer2, phospholipase

233 Conventional signalling by the group I metabotropic glutamate receptors, mGluR1 and mGluR5, occ

234 Altered function of the Gq-coupled, Group 1 metabotropic glutamate receptors, specifically mGlu5, is

235 trasynaptic signaling through ionotropic and metabotropic glutamate receptors, ultimately resulting i

236 o LAC responsiveness (leptin receptors Lepr, metabotropic glutamate receptors-2 mGlu2, neuropeptide-Y

237 mediated by GABA(A/B)-R in combination with metabotropic glutamate receptors.

238 ent inhibition via the activation of group I metabotropic glutamate receptors.

239 Ca(2+) -permeable AMPA receptors and group I metabotropic glutamate receptors.

240 f glutamate release by presynaptic Group III metabotropic glutamate receptors.

241 esponses were depressed by the activation of metabotropic glutamate receptors.

242 strocytic glutamate release, and presynaptic metabotropic glutamate receptors.

243 Ca(2+) -permeable AMPA receptors and group I metabotropic glutamate receptors.

244 pic receptors is independent of signaling by metabotropic glutamate receptors.

245 mature granule cells (mGCs) through group II metabotropic glutamate receptors.

246 ynaptic ionotropic and metabotropic GABA and metabotropic glutamate receptors.

247 Thus, before the onset of hearing, metabotropic glutamate signalling establishes a local ne

248 Antagonism of the postsynaptic metabotropic glutamate subtype 5 receptor is a novel app

249 cipal neurons, and reduced protein levels of metabotropic glutamate type 2 receptor (mGluR2) in the B

250 is an inactive photocaged derivative of the metabotropic glutamate type 5 (mGlu5) receptor negative

251 Here we show that D1 and metabotropic glutamate type 5 (mGlu5) receptors can form

252 e effects of ketamine on ligand binding to a metabotropic glutamatergic receptor (mGluR5) in individu

253 Recent evidence implicates dysregulation of metabotropic glutamatergic receptor 5 (mGluR5) in pathop

254 The metabotropic glutamatergic receptor subtype 5 (mGluR5) m

255 tostatin interneurons that depends on type I metabotropic glutamatergic receptors in the hippocampus.

256 occurred upon coactivating NMDAR and group I metabotropic glutamatergic receptors.

257 tains most channel mRNA relationships, while metabotropic influences may play a relatively smaller ro

258 Owing to the dual ionotropic/metabotropic nature of alpha7 receptors, signaling pathw

259 ikely arise from fast (ionotropic) and slow (metabotropic) neural mechanisms, and from interactions a

260 on of gene sets implicated in ionotropic and metabotropic neurotransmission as well as activation of

261 hat the structural consequences of mGluR and metabotropic NMDAR activation differ, and that a brake o

262 Manipulation of a previously described metabotropic NMDAR pathway (i.e., by preventing ligand b

263 abolite channel, pannexin-1, is regulated by metabotropic NMDAR signaling through Src kinase.

264 findings demonstrate an unexpected role for metabotropic NMDARs and postsynaptic Panx1 in suppressio

265 Abnormal function of the metabotropic, or Gq-coupled, glutamate receptor 5 (mGlu5

266 enosine mediates analgesia via activation of metabotropic P1 receptors.

267 reasing hyperexcitability, the slower-acting metabotropic P2Y receptors have received much less atten

268 ed through both ionotropic P2X receptors and metabotropic P2Y receptors.

269 by using male mice, we demonstrate that the metabotropic P2Y(1) receptor mediates either proconvulsi

270 te secretion by astrocytes via activation of metabotropic P2Y(1) receptors, recruitment of phospholip

271 ) signals in astrocytes after stimulation of metabotropic purinergic and protease-activated receptors

272 to fully characterize the contribution of a metabotropic purinergic P2Y receptor during acute seizur

273 brain slices, we found that TLQP21 impaired metabotropic purinergic signaling.

274 utation analysis revealed that the glutamate metabotropic receptor 3 (GRM3) gene gained a premature s

275 Ca(2+) signals and the absence of glutamate metabotropic receptor 5 in adults.

276 GPR39 encodes a Zn(2+)-binding metabotropic receptor known to modulate excitatory and i

277 in regulating affective states by modulating metabotropic receptor signaling pathways and neural acti

278 Acting at a single metabotropic receptor subtype, ACh exerts two opposing a

279 cannot be phosphorylated by CaMKII enhances metabotropic receptor-dependent depression in the hippoc

280 Activation of group I metabotropic receptors (mGluRs) is required for anti-Heb

281 Metabotropic receptors are responsible for so-called 'sl

282 ated' channel whose activation downstream of metabotropic receptors elicits inflammatory pain or itch

283 ine the brainwide expression patterns of all metabotropic receptors for acetylcholine, GABA, and glut

284 ge number of genes coding for ionotropic and metabotropic receptors for various neurotransmitters-glu

285 ling cascades consisting of ion channels and metabotropic receptors govern the electrical properties

286 rom climbing fibers activates ionotropic and metabotropic receptors on Golgi cells through spillover-

287 cetylcholine receptors are G-protein-coupled metabotropic receptors that control the excitability of

288 gamma subunits) are critical for coupling of metabotropic receptors to their downstream effectors.

289 They express ionotropic and metabotropic receptors, and can release gliotransmitters

290 entiation, desensitization and activation by metabotropic receptors.

291 and GABA signal through both ionotropic and metabotropic receptors.

292 hyperpolarization with activation of group I metabotropic receptors.

293 e, serotonin, and norepinephrine) signal via metabotropic receptors.

294 ing of striatal neurons relies critically on metabotropic receptors.

295 tal neurons is tightly controlled by various metabotropic receptors.

296 tects and converts mechanical stimuli into a metabotropic response.

297 (VTA) dopamine neuron activity, but how this metabotropic signaling impacts the complex roles of dopa

298 shown to potentiate NMDAR activity, induces metabotropic signaling via the Rho/ROCK pathway.

299 e shrinkage was initiated by non-ionotropic (metabotropic) signaling through NMDARs, and in wild-type

300 At metabotropic synapses, the molecular mechanisms underlyi